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Aliases for UBAP1 Gene

Aliases for UBAP1 Gene

  • Ubiquitin Associated Protein 1 2 3 5
  • Nasopharyngeal Carcinoma-Associated Gene 20 Protein 3 4
  • UBAP-1 3 4
  • Ubiquitin Associated Protein 2
  • NAG20 3
  • UBAP 3
  • UAP 3

External Ids for UBAP1 Gene

Previous HGNC Symbols for UBAP1 Gene

  • UBAP

Previous GeneCards Identifiers for UBAP1 Gene

  • GC09P034491
  • GC09P034348
  • GC09P034169
  • GC09P034026
  • GC09P034135

Summaries for UBAP1 Gene

Entrez Gene Summary for UBAP1 Gene

  • This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for UBAP1 Gene

UBAP1 (Ubiquitin Associated Protein 1) is a Protein Coding gene. Diseases associated with UBAP1 include Nasopharyngeal Carcinoma. GO annotations related to this gene include ubiquitin binding. An important paralog of this gene is UBAP1L.

UniProtKB/Swiss-Prot for UBAP1 Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.

Gene Wiki entry for UBAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBAP1 Gene

Genomics for UBAP1 Gene

Regulatory Elements for UBAP1 Gene

Enhancers for UBAP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBAP1 on UCSC Golden Path with GeneCards custom track

Promoters for UBAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBAP1 Gene

34,179,005 bp from pter
34,252,523 bp from pter
73,519 bases
Plus strand

Genomic View for UBAP1 Gene

Genes around UBAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBAP1 Gene

Proteins for UBAP1 Gene

  • Protein details for UBAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • B7Z348
    • B7Z8N9
    • D3DRL7
    • F5GXE2
    • F5H0J8
    • Q4V759
    • Q53FP7
    • Q5T7B3
    • Q6FI75
    • Q8NC52
    • Q8NCG6
    • Q8NCH9

    Protein attributes for UBAP1 Gene

    502 amino acids
    Molecular mass:
    55084 Da
    Quaternary structure:
    • Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoechiometry. Can be a component of ESCRT-I complexes containing VPS37B, VPS37C and VPS37D (in vitro) (PubMed:22405001), but may have a preference for the ESCRT-I complex containing VPS37A (PubMed:21757351). Interacts with PTPN23. Interacts (via UBA domains) with ubiquitinated proteins.
    • Sequence=BAC11162.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAH12084.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBAP1 Gene

    Alternative splice isoforms for UBAP1 Gene


neXtProt entry for UBAP1 Gene

Proteomics data for UBAP1 Gene at MOPED

Post-translational modifications for UBAP1 Gene

  • Ubiquitination at Lys 251 and Lys 264
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UBAP1 Gene

Domains & Families for UBAP1 Gene

Gene Families for UBAP1 Gene

Protein Domains for UBAP1 Gene


Suggested Antigen Peptide Sequences for UBAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The UMA domain mediates association with the ESCRT-I complex.
  • The UMA domain mediates association with the ESCRT-I complex.
  • Contains 2 UBA domains.
  • Contains 1 UMA domain.
genes like me logo Genes that share domains with UBAP1: view

Function for UBAP1 Gene

Molecular function for UBAP1 Gene

UniProtKB/Swiss-Prot Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.
genes like me logo Genes that share phenotypes with UBAP1: view

Animal Models for UBAP1 Gene

MGI Knock Outs for UBAP1:

Animal Model Products

miRNA for UBAP1 Gene

miRTarBase miRNAs that target UBAP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBAP1 Gene

Localization for UBAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBAP1 Gene

Cytoplasm, cytosol. Endosome. Note=Predominantly cytosolic. Recruited to endosomes as part of the ESCRT-I complex.

Subcellular locations from

Jensen Localization Image for UBAP1 Gene COMPARTMENTS Subcellular localization image for UBAP1 gene
Compartment Confidence
cytosol 5
endosome 5
golgi apparatus 5
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for UBAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex IDA 21757351
genes like me logo Genes that share ontologies with UBAP1: view

Pathways & Interactions for UBAP1 Gene

SuperPathways for UBAP1 Gene

No Data Available

Interacting Proteins for UBAP1 Gene

Selected Interacting proteins: Q9NZ09-UBAP1_HUMAN for UBAP1 Gene via UniProtKB I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for UBAP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for UBAP1 Gene

Drugs & Compounds for UBAP1 Gene

No Compound Related Data Available

Transcripts for UBAP1 Gene

Unigene Clusters for UBAP1 Gene

Ubiquitin associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBAP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - - -
SP6: - - - - -

Relevant External Links for UBAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBAP1 Gene

mRNA expression in normal human tissues for UBAP1 Gene

mRNA differential expression in normal tissues according to GTEx for UBAP1 Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for UBAP1 Gene

This gene is overexpressed in Bone (50.0) and Cervix (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for UBAP1 Gene

SOURCE GeneReport for Unigene cluster for UBAP1 Gene Hs.268963

mRNA Expression by UniProt/SwissProt for UBAP1 Gene

Tissue specificity: Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas.
genes like me logo Genes that share expression patterns with UBAP1: view

Protein tissue co-expression partners for UBAP1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for UBAP1 Gene

Orthologs for UBAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBAP1 35
  • 92.16 (n)
  • 92.03 (a)
UBAP1 36
  • 90 (a)
(Canis familiaris)
Mammalia UBAP1 35
  • 94.02 (n)
  • 95.22 (a)
UBAP1 36
  • 91 (a)
(Mus musculus)
Mammalia Ubap1 35
  • 91.24 (n)
  • 91.04 (a)
Ubap1 16
Ubap1 36
  • 90 (a)
(Pan troglodytes)
Mammalia UBAP1 35
  • 99.73 (n)
  • 99.4 (a)
UBAP1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ubap1 35
  • 91.17 (n)
  • 91.24 (a)
(Monodelphis domestica)
Mammalia UBAP1 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia UBAP1 36
  • 96 (a)
(Gallus gallus)
Aves UBAP1 35
  • 74.6 (n)
  • 76.4 (a)
UBAP1 36
  • 72 (a)
(Anolis carolinensis)
Reptilia UBAP1 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19563 35
ubap1 35
  • 64.89 (n)
  • 61.96 (a)
(Danio rerio)
Actinopterygii ubap1 35
  • 60.51 (n)
  • 57.31 (a)
zgc56228 35
ubap1 36
  • 51 (a)
Species with no ortholog for UBAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBAP1 Gene

Gene Tree for UBAP1 (if available)
Gene Tree for UBAP1 (if available)

Paralogs for UBAP1 Gene

Paralogs for UBAP1 Gene

genes like me logo Genes that share paralogs with UBAP1: view

Variants for UBAP1 Gene

Sequence variations from dbSNP and Humsavar for UBAP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs16935457 - 34,242,096(+) CCAAA(A/T)ACTGG nc-transcript-variant, reference, missense
rs961183 -- 34,243,686(-) atggc(A/G)aaacc intron-variant
rs1122114 -- 34,247,330(+) TACTT(C/T)TAAAT intron-variant
rs1141738 -- 34,223,930(-) TCCCa(A/C)aaaaa intron-variant
rs7469160 -- 34,244,431(+) ttttt(A/T)atcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBAP1 Gene

Variant ID Type Subtype PubMed ID
nsv893028 CNV Gain 21882294
nsv509300 CNV Insertion 20534489
esv2738386 CNV Deletion 23290073
esv2673377 CNV Deletion 23128226
nsv824911 CNV Loss 20364138
nsv893034 CNV Loss 21882294
dgv8166n71 CNV Loss 21882294

Variation tolerance for UBAP1 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UBAP1 Gene

Disorders for UBAP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBAP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nasopharyngeal carcinoma
  • malignant neoplasm of nasopharynx
- elite association - COSMIC cancer census association via MalaCards
Search UBAP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBAP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with UBAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBAP1 Gene

Publications for UBAP1 Gene

  1. UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. (PMID: 21757351) Stefani F. … Woodman P. (Curr. Biol. 2011) 2 3 4 67
  2. Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration. (PMID: 19217189) Rollinson S. … Pickering-Brown S.M. (Neurobiol. Aging 2009) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for UBAP1 Gene

Sources for UBAP1 Gene