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Aliases for UBAP1 Gene

Aliases for UBAP1 Gene

  • Ubiquitin Associated Protein 1 2 3
  • Nasopharyngeal Carcinoma-Associated Gene 20 Protein 3 4
  • UBAP-1 3 4
  • UBAP 3 6
  • Ubiquitin-Associated Protein 1 3
  • Ubiquitin Associated Protein 2
  • NAG20 3
  • UAP 3

External Ids for UBAP1 Gene

Previous HGNC Symbols for UBAP1 Gene

  • UBAP

Previous GeneCards Identifiers for UBAP1 Gene

  • GC09P034491
  • GC09P034348
  • GC09P034169
  • GC09P034026
  • GC09P034135

Summaries for UBAP1 Gene

Entrez Gene Summary for UBAP1 Gene

  • This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for UBAP1 Gene

UBAP1 (Ubiquitin Associated Protein 1) is a Protein Coding gene. Diseases associated with UBAP1 include nasopharyngeal carcinoma and intermediate coronary syndrome. GO annotations related to this gene include ubiquitin binding. An important paralog of this gene is UBAP1L.

UniProtKB/Swiss-Prot for UBAP1 Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.

Gene Wiki entry for UBAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBAP1 Gene

Genomics for UBAP1 Gene

Regulatory Elements for UBAP1 Gene

Genomic Location for UBAP1 Gene

Start:
34,179,005 bp from pter
End:
34,252,523 bp from pter
Size:
73,519 bases
Orientation:
Plus strand

Genomic View for UBAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBAP1 Gene

Proteins for UBAP1 Gene

  • Protein details for UBAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ09-UBAP1_HUMAN
    Recommended name:
    Ubiquitin-associated protein 1
    Protein Accession:
    Q9NZ09
    Secondary Accessions:
    • B7Z348
    • B7Z8N9
    • D3DRL7
    • F5GXE2
    • F5H0J8
    • Q4V759
    • Q53FP7
    • Q5T7B3
    • Q6FI75
    • Q8NC52
    • Q8NCG6
    • Q8NCH9

    Protein attributes for UBAP1 Gene

    Size:
    502 amino acids
    Molecular mass:
    55084 Da
    Quaternary structure:
    • Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoechiometry. Can be a component of ESCRT-I complexes containing VPS37B, VPS37C and VPS37D (in vitro) (PubMed:22405001), but may have a preference for the ESCRT-I complex containing VPS37A (PubMed:21757351). Interacts with PTPN23. Interacts (via UBA domains) with ubiquitinated proteins.
    SequenceCaution:
    • Sequence=BAC11162.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAH12084.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBAP1 Gene

    Alternative splice isoforms for UBAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBAP1 Gene

Proteomics data for UBAP1 Gene at MOPED

Post-translational modifications for UBAP1 Gene

  • Ubiquitination at Lys251 and Lys264
  • Modification sites at PhosphoSitePlus

Other Protein References for UBAP1 Gene

Antibody Products

No data available for DME Specific Peptides for UBAP1 Gene

Domains for UBAP1 Gene

Protein Domains for UBAP1 Gene

Suggested Antigen Peptide Sequences for UBAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZ09

UniProtKB/Swiss-Prot:

UBAP1_HUMAN :
  • Q9NZ09
Domain:
  • The UMA domain mediates association with the ESCRT-I complex.
  • Contains 2 UBA domains.
  • Contains 1 UMA domain.
genes like me logo Genes that share domains with UBAP1: view

No data available for Gene Families for UBAP1 Gene

Function for UBAP1 Gene

Molecular function for UBAP1 Gene

UniProtKB/Swiss-Prot Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.

Gene Ontology (GO) - Molecular Function for UBAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0043130 ubiquitin binding IDA 21757351
genes like me logo Genes that share ontologies with UBAP1: view

Phenotypes for UBAP1 Gene

MGI mutant phenotypes for UBAP1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with UBAP1: view

Animal Model Products

miRNA for UBAP1 Gene

miRTarBase miRNAs that target UBAP1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBAP1 Gene

Localization for UBAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBAP1 Gene

Cytoplasm, cytosol. Endosome. Note=Predominantly cytosolic. Recruited to endosomes as part of the ESCRT-I complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBAP1 Gene COMPARTMENTS Subcellular localization image for UBAP1 gene
Compartment Confidence
cytosol 2
nucleus 2
endosome 1
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UBAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex IDA 21757351
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA 21757351
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with UBAP1: view

Pathways for UBAP1 Gene

SuperPathways for UBAP1 Gene

No Data Available

Interacting Proteins for UBAP1 Gene

Selected Interacting proteins: Q9NZ09-UBAP1_HUMAN for UBAP1 Gene via I2D UniProtKB

Symbol External ID(s) Details
PPIC
UBC

Gene Ontology (GO) - Biological Process for UBAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP 21757351
genes like me logo Genes that share ontologies with UBAP1: view

No data available for Pathways by source for UBAP1 Gene

Transcripts for UBAP1 Gene

Unigene Clusters for UBAP1 Gene

Ubiquitin associated protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBAP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBAP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - - -
SP6: - - - - -
SP7:

Relevant External Links for UBAP1 Gene

GeneLoc Exon Structure for
UBAP1
ECgene alternative splicing isoforms for
UBAP1

Expression for UBAP1 Gene

mRNA expression in normal human tissues for UBAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBAP1 Gene

This gene is overexpressed in Whole Blood (5.7).

Protein differential expression in normal tissues for UBAP1 Gene

This gene is overexpressed in Bone (50.0) and Cervix (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for UBAP1 Gene

SOURCE GeneReport for Unigene cluster for UBAP1 Gene Hs.268963

mRNA Expression by UniProt/SwissProt for UBAP1 Gene

Q9NZ09-UBAP1_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas.
genes like me logo Genes that share expressions with UBAP1: view

Expression partners for UBAP1 Gene

In Situ Assay Products

Orthologs for UBAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBAP1 35
  • 92.16 (n)
  • 92.03 (a)
UBAP1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBAP1 35
  • 94.02 (n)
  • 95.22 (a)
UBAP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubap1 35
  • 91.24 (n)
  • 91.04 (a)
Ubap1 16
Ubap1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBAP1 35
  • 99.73 (n)
  • 99.4 (a)
UBAP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubap1 35
  • 91.17 (n)
  • 91.24 (a)
oppossum
(Monodelphis domestica)
Mammalia UBAP1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBAP1 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBAP1 35
  • 74.6 (n)
  • 76.4 (a)
UBAP1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBAP1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19563 35
ubap1 35
  • 64.89 (n)
  • 61.96 (a)
zebrafish
(Danio rerio)
Actinopterygii ubap1 35
  • 60.51 (n)
  • 57.31 (a)
zgc56228 35
ubap1 36
  • 51 (a)
OneToOne
Species with no ortholog for UBAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBAP1 Gene

ENSEMBL:
Gene Tree for UBAP1 (if available)
TreeFam:
Gene Tree for UBAP1 (if available)

Paralogs for UBAP1 Gene

Paralogs for UBAP1 Gene

genes like me logo Genes that share paralogs with UBAP1: view

Variants for UBAP1 Gene

Sequence variations from dbSNP and Humsavar for UBAP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs961183 -- 34,243,686(-) atggc(A/G)aaacc intron-variant
rs1122114 -- 34,247,330(+) TACTT(C/T)TAAAT intron-variant
rs1141738 -- 34,223,930(-) TCCCa(A/C)aaaaa intron-variant
rs1537217 -- 34,211,402(+) CTTTT(C/T)GTGTA intron-variant
rs1537218 -- 34,211,526(+) GAAGC(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBAP1 Gene

Variant ID Type Subtype PubMed ID
nsv893028 CNV Gain 21882294
nsv509300 CNV Insertion 20534489
esv2738386 CNV Deletion 23290073
esv2673377 CNV Deletion 23128226
nsv824911 CNV Loss 20364138
nsv893034 CNV Loss 21882294
dgv8166n71 CNV Loss 21882294

Relevant External Links for UBAP1 Gene

HapMap Linkage Disequilibrium report
UBAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBAP1 Gene

Disorders for UBAP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for UBAP1 Gene in MalaCards »

(2) Diseases for UBAP1 Gene including...

Relevant External Links for UBAP1

Genetic Association Database (GAD)
UBAP1
Human Genome Epidemiology (HuGE) Navigator
UBAP1
genes like me logo Genes that share disorders with UBAP1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for UBAP1 Gene

Publications for UBAP1 Gene

  1. Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration. (PMID: 19217189) Rollinson S. … Pickering-Brown S.M. (Neurobiol. Aging 2009) 3 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Isolation and characterization of a novel cDNA, UBAP1, derived from the tumor suppressor locus in human chromosome 9p21-22. (PMID: 11599797) Qian J. … Li G. (J. Cancer Res. Clin. Oncol. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for UBAP1 Gene

Sources for UBAP1 Gene

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