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Aliases & Descriptions for UBAP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC119669 2 | | MGC8710 2 | | NAG20 2 | | OTTHUMP00000000480 2 | | OTTHUMP00000000481 2 | | UAP 2 | | UBAP 2, 3, 5 |
| | | Descriptions |
|---|
| Nasopharyngeal carcinoma-associated gene 20 protein 3 | | ubiquitin associated protein 1 | | ubiquitin associated protein 1 2 |
|
| | Search outside databases for aliases for UBAP1 genePrevious GC identifers: GC09P034491 GC09P034348 GC09P034026 |
Summaries for UBAP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for UBAP1: This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. [provided by RefSeq] Gene Wiki entry for UBAP1 |
Genomic Location for UBAP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the UBAP1 gene 
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13.3UBAP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P034169:
(about GC identifiers)
Start:
|
34,169,011 bp from pter |
End:
|
34,242,521 bp from pter |
Size:
|
73,511 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000009.10 NT_008413.17
| Proteins for UBAP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: UBAP1_HUMAN, Q9NZ09 (See
protein sequence)Recommended Name: Ubiquitin-associated protein 1 Size: 502 amino acids; 55084 Da
PDB structures from and Proteopedia :1WGN (3D)
 
Secondary accessions: Q4V759 Q53FP7 Q5T7B3 Q6FI75 Q8NC52 Q8NCG6 Q8NCH9Alternative splicing: 2 isoforms: Q9NZ09-1 Q9NZ09-2 REFSEQ proteins: NP_057609.2
ENSEMBL proteins: ENSP00000352541 ENSP00000297661 ENSP00000368484
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for UBAP1: Assays for UBAP1: | Protein
Domains/ Families for UBAP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NZ09
ProtoNet protein and cluster: Q9NZ09 1 Blocks protein family: IPB000449 Ubiquitin-associated domain
UniProtKB/Swiss-Prot: UBAP1_HUMAN, Q9NZ09Similarity: Contains 2 UBA domains | Gene Function for UBAP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016525
Applied Biosystems Silencer® siRNAs for UBAP1
Sigma-Aldrich siRNA and siRNA Panels for UBAP1  Sigma-Aldrich shRNA for UBAP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016525                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016525                                  untagged cDNA clones in CMV expression vector (see all 2): NM_016525 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016525
| Pathways & Interactions for UBAP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for UBAP1 (ENSP000003525413) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds for UBAP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for UBAP1
|
Transcripts for UBAP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016525
Sigma-Aldrich siRNA and siRNA Panels for UBAP1  Sigma-Aldrich shRNA for UBAP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016525 REFSEQ mRNAs for UBAP1 gene: NM_016525.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016525               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016525                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016525                                  untagged cDNA clones in CMV expression vector (see all 2): NM_016525  Additional cDNA sequence: AF130079.1 AF222043.2 AK074426.1 AK074724.1 AK074745.1 AK074812.1 AK074969.1 AK074995.1 AK223235.1 AK295482.1 AK303711.1 AK309329.1 AL136733.1 BC020950.1 BC098141.1 BC098316.1 BC099726.1 BC100668.1 CR533551.1 CR620852.1 CR621006.1 CR624683.1 21 DOTS entries: DT.99954471 DT.100811475 DT.85105562 DT.100811480 DT.40190940 DT.100811478 DT.121202525 DT.91751636 DT.95199215 DT.95364726 DT.99981033 DT.95153446 DT.95199211 DT.100663602 DT.101982850 DT.121202511 DT.121202542 DT.40228494 DT.91770670 DT.121202518 DT.87014157 24/209 AceView cDNA sequences (see all 209
):BU731774 BI766247 BU166893 BP360371 AW593698 CB156898 CD369110 BQ059715 BM473450 AA908859 AU279488 BQ049210 D62515 AA938430 NM_016525 BE301381 BP340766 AA705563 BQ642063 BC020950 CR624683 BG818050 AI354695 AI445067
highest scoring ESTs for UBAP1:AI679180 AA025100 AA025206 AA056988 AA149434 AA176548 AA190830 AA443759 AA648447 AA693356 Unigene Cluster for UBAP1: Ubiquitin associated protein 1 Hs.268963 [show with all ESTs]Unigene Representative Sequence: AK074969
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UBAP1 (see all 7
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7 | ^ | 8 | ^ | 9 | |
| SP1: | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for UBAP1
3 Ensembl transcripts including schematic representations: ENST00000359544
ENST00000297661
ENST00000379186
|
Expression for UBAP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBAP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBAP1
1 / 2 / 3 6 probe-sets matching UBAP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.268963 UniProtKB/Swiss-Prot: UBAP1_HUMAN, Q9NZ09Tissue specificity: Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas |
Orthologs for UBAP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBAP1 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for UBAP1
ENSEMBL Gene Tree for UBAP1 | Paralogs for UBAP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for UBAP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for UBAP1 (up to first 250kb)
|
Disorders & Mutations for UBAP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609787
|
Medical News for UBAP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for UBAP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for UBAP1 gene (see all 16
):- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)3, 4 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Isolation and characterization of a novel cDNA, UBAP1, derived from the tumor suppressor locus in human chromosome 9p21-22. (PubMed id 11599797)3, 4 Qian J.... Li G. (2001)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3, 4 Wiemann S.... Poustka A. (2001)
- Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration. (PubMed id 19217189)1, 3 Rollinson S....Pickering-Brown S.M. (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
- Purification of novel UBAP1 protein and its decreased expression on nasopharyngeal carcinoma tissue microarray. (PubMed id 16226037)3 Xiao B....Li G. (2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)3 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for UBAP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBAP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBAP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBAP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for UBAP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for UBAP1:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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