Aliases for UBAP1 Gene
External Ids for UBAP1 Gene
Previous HGNC Symbols for UBAP1 Gene
Previous GeneCards Identifiers for UBAP1 Gene
This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
GeneCards Summary for UBAP1 Gene
UBAP1 (Ubiquitin Associated Protein 1) is a Protein Coding gene. Diseases associated with UBAP1 include Nasopharyngeal Carcinoma. GO annotations related to this gene include ubiquitin binding. An important paralog of this gene is UBAP1L.
UniProtKB/Swiss-Prot for UBAP1 Gene
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.