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UBAP1 Gene

protein-coding   GIFtS: 54
GCID: GC09P034179

Ubiquitin Associated Protein 1

(Previous name: ubiquitin associated protein)
(Previous symbol: UBAP)
  See UBAP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Associated Protein 11 2     Ubiquitin Associated Protein1
UBAP1 2 5     NAG202
Nasopharyngeal Carcinoma-Associated Gene 20 Protein2 3     UAP2
UBAP-12 3     Ubiquitin-Associated Protein 12

External Ids:    HGNC: 124611   Entrez Gene: 512712   Ensembl: ENSG000001650067   OMIM: 6097875   UniProtKB: Q9NZ093   

Export aliases for UBAP1 gene to outside databases

Previous GC identifers: GC09P034491 GC09P034348 GC09P034169 GC09P034026 GC09P034135


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBAP1 Gene:
This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and
the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding
domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a
refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into
account its cytogenetic location, this UBA domain family member is being studies as a putative target for
mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jan 2010)

GeneCards Summary for UBAP1 Gene:
UBAP1 (ubiquitin associated protein 1) is a protein-coding gene. Diseases associated with UBAP1 include neurocirculatory asthenia, and intermediate coronary syndrome. GO annotations related to this gene include ubiquitin binding. An important paralog of this gene is UBAP1L.

UniProtKB/Swiss-Prot: UBAP1_HUMAN, Q9NZ09
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated
cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies
(MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2

Gene Wiki entry for UBAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBAP1 gene promoter:
         NF-YB   CBF-B   CBF-A   GATA-3   NF-YA   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBAP1 promoter sequence
   Search Chromatin IP Primers for UBAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

UBAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBAP1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P034179:  view genomic region     (about GC identifiers)

Start:
34,179,003 bp from pter      End:
34,252,521 bp from pter
Size:
73,519 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for UBAP1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBAP1_HUMAN, Q9NZ09 (See protein sequence)
Recommended Name: Ubiquitin-associated protein 1  
Size: 502 amino acids; 55084 Da
Subunit: Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of
TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoechiometry. Can be a component of ESCRT-I complexes containing
VPS37B, VPS37C and VPS37D (in vitro) (PubMed:22405001), but may have a preference for the ESCRT-I complex
containing VPS37A (PubMed:21757351). Interacts with PTPN23. Interacts (via UBA domains) with ubiquitinated
proteins
Sequence caution: Sequence=BAC11162.1; Type=Erroneous initiation; Sequence=BAH12084.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for UBAP1:
1WGN (3D)        4AE4 (3D)    
Secondary accessions: B7Z348 B7Z8N9 D3DRL7 F5GXE2 F5H0J8 Q4V759 Q53FP7 Q5T7B3 Q6FI75 Q8NC52
Q8NCG6 Q8NCH9
Alternative splicing: 4 isoforms:  Q9NZ09-1   Q9NZ09-2   Q9NZ09-3   Q9NZ09-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBAP1: NX_Q9NZ09

Explore proteomics data for UBAP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys251, Lys264
  • Modification sites at PhosphoSitePlus

  • See UBAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001164672.1  NP_001164673.1  NP_001164674.1  NP_001164675.1  NP_057609.2  

    ENSEMBL proteins: 
     ENSP00000297661   ENSP00000368484   ENSP00000352541   ENSP00000441024   ENSP00000439806  
     ENSP00000440456   ENSP00000439976  

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    antibodies-online peptides for UBAP1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR009060 UBA-like
     IPR015940 UBA/transl_elong_EF1B_N_euk
     IPR023340 UMA

    Graphical View of Domain Structure for InterPro Entry Q9NZ09

    ProtoNet protein and cluster: Q9NZ09

    1 Blocks protein domain: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: UBAP1_HUMAN, Q9NZ09
    Domain: The UMA domain mediates association with the ESCRT-I complex
    Similarity: Contains 2 UBA domains
    Similarity: Contains 1 UMA domain


    Find genes that share domains with UBAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBAP1_HUMAN, Q9NZ09
    Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated
    cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies
    (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0043130ubiquitin binding IDA--
         
    Find genes that share ontologies with UBAP1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ubap1):
     mortality/aging 

    Find genes that share phenotypes with UBAP1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UBAP1

    miRNA
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    miRTarBase miRNAs that target UBAP1:
    hsa-mir-141-3p (MIRT003280)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBAP1_HUMAN, Q9NZ09: Cytoplasm, cytosol. Endosome. Note=Predominantly cytosolic. Recruited to endosomes as part
    of the ESCRT-I complex
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endosome1
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000813ESCRT I complex IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA--

    Find genes that share ontologies with UBAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBAP1
    Interactions:

        Search GeneGlobe Interaction Network for UBAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for UBAP1 (Q9NZ093 ENSP000002976614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    TSG101ENSP000002519684STRING: ENSP00000251968
    VPS28ENSP000003665654STRING: ENSP00000366565
    VPS37AENSP000003186294STRING: ENSP00000318629
    VPS37CENSP000003017654STRING: ENSP00000301765
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0043162ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP--

    Find genes that share ontologies with UBAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for UBAP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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    REFSEQ mRNAs for UBAP1 gene (5 alternative transcripts): 
    NM_001171201.1  NM_001171202.1  NM_001171203.2  NM_001171204.2  NM_016525.4  

    Unigene Cluster for UBAP1:

    Ubiquitin associated protein 1
    Hs.268963  [show with all ESTs]
    Unigene Representative Sequence: NM_001171203
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297661 ENST00000379186 ENST00000359544(uc003ztz.3) ENST00000545103(uc011loj.2)
    ENST00000543944(uc010mka.2 uc011loi.2) ENST00000536252(uc022bfy.1)
    ENST00000540348(uc003zty.3 uc022bfz.1 uc003ztx.3)
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    Additional mRNA sequence: 

    AF130079.1 AF222043.2 AK074426.1 AK074724.1 AK074812.1 AK074969.1 AK074995.1 AK223235.1 
    AK295482.1 AK303711.1 AL136733.1 BC020950.1 BC098141.1 BC098316.1 BC099726.1 BC100668.1 
    CR533551.1 NR_033243.2 XR_158845.2 XR_159514.2 XR_171771.1 

    21 DOTS entries:

    DT.99954471  DT.100811475  DT.85105562  DT.100811480  DT.40190940  DT.100811478  DT.121202525  DT.91751636 
    DT.95199215  DT.95364726  DT.99981033  DT.95153446  DT.95199211  DT.100663602  DT.101982850  DT.121202511 
    DT.121202542  DT.40228494  DT.91770670  DT.121202518  DT.87014157 

    Selected AceView cDNA sequences (see all 209):

    BM473450 AA705563 CD369110 BP360371 CR624683 AI354695 AI445067 BG818050 
    D62515 AU279488 BQ049210 NM_016525 BP340766 AA938430 AW593698 BU731774 
    BQ642063 BE301381 BI766247 BQ431676 BQ059715 AA908859 CB156898 BC020950 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBAP1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9
    SP1:              -     -           -                                                               
    SP2:              -                 -                                                               
    SP3:                    -           -                                                               
    SP4:              -     -     -     -                                                               
    SP5:              -     -           -     -                                                         


    ECgene alternative splicing isoforms for UBAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTAGTTGG
    UBAP1 Expression
    About this image


    UBAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    UBAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.268963

    UniProtKB/Swiss-Prot: UBAP1_HUMAN, Q9NZ09
    Tissue specificity: Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and
    pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for UBAP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubap11 , 5 ubiquitin-associated protein 11, 5 91.24(n)1
    91.04(a)1
      4 (21.43 cM)5
    671231  NM_023305.31  NP_075794.31 
     413489965 
    chicken
    (Gallus gallus)
    Aves UBAP11 ubiquitin associated protein 1 74.6(n)
    76.4(a)
      431652  XM_004937098.1  XP_004937155.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBAP16
    ubiquitin associated protein 1
    69(a)
    1 ↔ 1
    GL343372.1(957706-993963)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU914310.12   -- 74.73(n)    BU914310.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc562282 similar to ubiquitin associated protein 1 73.86(n)   393183  BC046008.1 


    ENSEMBL Gene Tree for UBAP1 (if available)
    TreeFam Gene Tree for UBAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBAP1 gene
    UBAP1L2  

    Find genes that share paralogs with UBAP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBAP1 (see all 1328)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70380441,2
    C,F,A,H--34177071(+) cctccA/Tcctct 6 -- us2k1 trp36Minor allele frequency- T:0.21NA WA 14
    rs1859473321,2
    --34177261(+) ACAGGC/TGTGAG 6 -- us2k10--------
    rs345800301,2
    C--34177305(+) TTTTT-/T/TT  
            
    GAGAC
    6 -- us2k11NA 2
    rs1488654781,2
    --34177340(+) CTAGAA/GTGCAA 6 -- us2k10--------
    rs1910443091,2
    --34177420(+) ACTAGA/CTGGGA 6 -- us2k10--------
    rs78507951,2
    C,F,H--34177658(+) caggcG/Attagc 6 -- us2k16Minor allele frequency- A:0.02NS NA 676
    rs1408540521,2
    C--34177678(+) TAGTC-/ATTTT 
            
    ATTTT
    6 -- us2k10--------
    rs1379201751,2
    --34177783(+) GGCTCA/GAGTGA 6 -- us2k10--------
    rs1424315441,2
    --34177795(+) CCTCCA/TATCTC 6 -- us2k10--------
    rs15482901,2
    C,F,A--34177891(+) gcccaG/AgctCA 6 -- us2k16Minor allele frequency- A:0.02NA WA 262

    HapMap Linkage Disequilibrium report for UBAP1 (34179003 - 34252521 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for UBAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738386CNV Deletion23290073
    esv2673377CNV Deletion23128226
    nsv509300CNV Insertion20534489
    dgv8166n71CNV Loss21882294
    nsv824911CNV Loss20364138
    nsv893034CNV Loss21882294
    nsv893028CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBAP1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609787    OMIM disorders: --

    2 diseases for UBAP1:    
    About MalaCards
    neurocirculatory asthenia    intermediate coronary syndrome

    4 diseases from the University of Copenhagen DISEASES database for UBAP1:
    Intermediate coronary syndrome     Myocardial infarction     Neurocirculatory asthenia     Coronary heart disease

    Find genes that share disorders with UBAP1           About GenesLikeMe

    Genetic Association Database (GAD): UBAP1
    Human Genome Epidemiology (HuGE) Navigator: UBAP1 (1 document)

    Export disorders for UBAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBAP1 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with UBAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. (PubMed id 22405001)1, 2 Agromayor M.... Williams R.L. (Structure 2012)
    2. UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. (PubMed id 21757351)1, 2 Stefani F.... Woodman P. (Curr. Biol. 2011)
    3. Is KIF24 a genetic risk factor for Frontotemporal Lobar Degeneration? (PubMed id 20670673)1, 4 Venturelli E....Galimberti D. (Neurosci. Lett. 2010)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Isolation and characterization of a novel cDNA, UBAP1, derived from the tumor suppressor locus in human chromosome 9p21-22. (PubMed id 11599797)1, 2 Qian J.... Li G. (J. Cancer Res. Clin. Oncol. 2001)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration. (PubMed id 19217189)1, 9 Rollinson S....Pickering-Brown S.M. (Neurobiol. Aging 2009)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51271 HGNC: 12461 AceView: UBAP1 Ensembl:ENSG00000165006 euGenes: HUgn51271
    ECgene: UBAP1 H-InvDB: UBAP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBAP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBAP1 gene:
    Search GeneIP for patents involving UBAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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