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UBALD2 Gene

protein-coding   GIFtS: 28
GCID: GC17P074262

UBA-Like Domain Containing 2

(Previous names: family with sequence similarity 100, member B)
(Previous symbol: FAM100B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UBA-Like Domain Containing 21 2
FAM100B1 2 3
Family With Sequence Similarity 100, Member B1 2
Protein FAM100B2
UBA-Like Domain-Containing Protein 22

External Ids:    HGNC: 284381   Entrez Gene: 2839912   Ensembl: ENSG000001852627   UniProtKB: Q8IYN63   

Export aliases for UBALD2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UBALD2 Gene:
UBALD2 (UBA-like domain containing 2) is a protein-coding gene. An important paralog of this gene is UBALD1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for UBALD2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBALD2 promoter sequence
   Search Chromatin IP Primers for UBALD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBALD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

UBALD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBALD2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P074262:  view genomic region     (about GC identifiers)

Start:
74,261,283 bp from pter      End:
74,267,379 bp from pter
Size:
6,097 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBAD2_HUMAN, Q8IYN6 (See protein sequence)
Recommended Name: UBA-like domain-containing protein 2  
Size: 164 amino acids; 17877 Da
1 PDB 3D structure from and Proteopedia for UBALD2:
2DZL (3D)    

Explore the universe of human proteins at neXtProt for UBALD2: NX_Q8IYN6

Explore proteomics data for UBALD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UBALD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872371.1  
    ENSEMBL proteins: 
     ENSP00000331298   ENSP00000468297   ENSP00000466518  

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    Search eBioscience for ELISAs for UBALD2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q8IYN6

    ProtoNet protein and cluster: Q8IYN6

    UniProtKB/Swiss-Prot: UBAD2_HUMAN, Q8IYN6
    Similarity: Belongs to the UBALD family


    Find genes that share domains with UBALD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with UBALD2           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBALD2
    Interactions:

        Search GeneGlobe Interaction Network for UBALD2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBALD2 (UBAD2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBALD2 gene: 
    NM_182565.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327490(uc010wsy.1) ENST00000587913 ENST00000589240
    miRNA
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    Selected AceView cDNA sequences (see all 176):

    AI831873 N91506 AA689580 BE349197 CA432334 BU683174 AI193443 AI083809 
    AA890416 AI251455 BM673147 BF344266 AI582849 AI672588 AI337032 BF343516 
    CR599986 AI990551 BQ672244 AI743889 AW518876 BQ086192 CR616618 AI198030 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBALD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UBALD2 Expression
    About this image

    UBALD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBALD2 Protein Expression
        Custom PCR Arrays for UBALD2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for UBALD2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubald21 , 5 family with sequence similarity 100, member B5
    UBA-like domain containing 21
    90.39(n)1
    90.8(a)1
      11 (81.29 cM)5
    3193701  NM_176902.31  NP_795876.11 
     1164340945 
    lizard
    (Anolis carolinensis)
    Reptilia UBALD26
    UBA-like domain containing 2
    83(a)
    1 ↔ 1
    2(112539559-112848836)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.54802 Xenopus laevis transcribed sequences 79.94(n)    48053986 
    zebrafish
    (Danio rerio)
    Actinopterygii ubald21 UBA-like domain containing 2 70.86(n)
    72.33(a)
      553806  NM_001020768.1  NP_001018604.1 


    ENSEMBL Gene Tree for UBALD2 (if available)
    TreeFam Gene Tree for UBALD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBALD2 gene
    UBALD12  
    2 SIMAP similar genes for UBALD2 using alignment to 3 protein entries:     UBAD2_HUMAN (see all proteins):
    UBALD1    FAM100A

    Find genes that share paralogs with UBALD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBALD2 (see all 192)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476526831,2
    --74259337(+) CAAGCC/TATACT 1 -- us2k10--------
    rs1908873411,2
    --74259447(+) AAAAAC/TGAACC 1 -- us2k10--------
    rs1421310951,2
    --74259495(+) TTCATC/TAGTAC 1 -- us2k10--------
    rs1821866791,2
    C--74259544(+) TAAACG/TTTAAA 1 -- us2k10--------
    rs1459663281,2
    --74259621(+) CACGAC/TGTGCT 1 -- us2k10--------
    rs1383700111,2
    --74259720(+) AGTTCC/TCCTGA 1 -- us2k10--------
    rs1856254011,2
    --74259763(+) TATTTA/GTCTTC 1 -- us2k10--------
    rs1495839351,2
    --74259781(+) CTTCTA/GCCCCT 1 -- us2k10--------
    rs776087351,2
    C,F--74259813(+) TAGTTC/TTTTTC 1 -- us2k11Minor allele frequency- T:0.05NA 120
    rs1899363131,2
    --74259878(+) TGGAAA/GCTCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBALD2 (74261283 - 74267379 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UBALD2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBALD2
    DNA2.0 Custom Variant and Variant Library Synthesis for UBALD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBALD2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with UBALD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    3. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283991 HGNC: 28438 AceView: MGC29814 Ensembl:ENSG00000185262 euGenes: HUgn283991
    ECgene: UBALD2 H-InvDB: UBALD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBALD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBALD2 gene:
    Search GeneIP for patents involving UBALD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBALD2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBALD2
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