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Aliases for UBALD2 Gene

Aliases for UBALD2 Gene

  • UBA Like Domain Containing 2 2 3 5
  • Family With Sequence Similarity 100, Member B 2 3
  • FAM100B 3 4
  • UBA-Like Domain-Containing Protein 2 3
  • UBA-Like Domain Containing 2 2
  • Protein FAM100B 3

External Ids for UBALD2 Gene

Previous HGNC Symbols for UBALD2 Gene

  • FAM100B

Previous GeneCards Identifiers for UBALD2 Gene

  • GC17P074262

Summaries for UBALD2 Gene

GeneCards Summary for UBALD2 Gene

UBALD2 (UBA Like Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is UBALD1.

Additional gene information for UBALD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBALD2 Gene

Genomics for UBALD2 Gene

Regulatory Elements for UBALD2 Gene

Enhancers for UBALD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H076258 2 FANTOM5 Ensembl ENCODE dbSUPER 12.9 +2.8 2774 19.6 DMAP1 YY1 ZNF143 SP3 ZC3H11A NFYC MEF2D ZNF610 ZNF585B GLIS1 UNK ENSG00000267342 SRSF2 TRIM65 ENSG00000266980 ENSG00000267546 EXOC7 RNF157 MFSD11 PRPSAP1
GH17H076238 1.3 ENCODE dbSUPER 12 -24.5 -24528 3.6 ATF1 ARNT SIN3A ZNF2 GLIS2 GATA2 FOS ATF7 SP3 NFYC RNF157 UBALD2 FOXJ1 QRICH2 AANAT UBE2O LOC105371896
GH17H076250 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.9 -13.0 -13018 3.1 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 RNF157 FOXJ1 JMJD6 ENSG00000267342 UNC13D UBALD2 H3F3B RHBDF2 ACOX1 WBP2
GH17H076279 1.4 Ensembl ENCODE dbSUPER 8.4 +14.3 14349 0.5 ELF3 PTBP1 RB1 ARID4B ZNF76 DMAP1 DNMT3B ZNF2 RAD21 ZNF121 UBALD2 QRICH2
GH17H076497 1.8 FANTOM5 ENCODE dbSUPER 6.2 +234.7 234664 5.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ENSG00000267543 ENSG00000267342 JMJD6 UNK RHBDF2 ENSG00000267546 SAP30BP ENSG00000272386 TRIM65 SRSF2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBALD2 on UCSC Golden Path with GeneCards custom track

Promoters for UBALD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098538 698 1801 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766

Genomic Locations for UBALD2 Gene

Genomic Locations for UBALD2 Gene
chr17:76,265,202-76,271,299
(GRCh38/hg38)
Size:
6,098 bases
Orientation:
Plus strand
chr17:74,261,283-74,267,379
(GRCh37/hg19)

Genomic View for UBALD2 Gene

Genes around UBALD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBALD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBALD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBALD2 Gene

Proteins for UBALD2 Gene

  • Protein details for UBALD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYN6-UBAD2_HUMAN
    Recommended name:
    UBA-like domain-containing protein 2
    Protein Accession:
    Q8IYN6

    Protein attributes for UBALD2 Gene

    Size:
    164 amino acids
    Molecular mass:
    17877 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBALD2 Gene

neXtProt entry for UBALD2 Gene

Post-translational modifications for UBALD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBALD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBALD2 Gene

Domains & Families for UBALD2 Gene

Gene Families for UBALD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBALD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UBALD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYN6

UniProtKB/Swiss-Prot:

UBAD2_HUMAN :
  • Belongs to the UBALD family.
Family:
  • Belongs to the UBALD family.
genes like me logo Genes that share domains with UBALD2: view

Function for UBALD2 Gene

genes like me logo Genes that share phenotypes with UBALD2: view

Animal Model Products

miRNA for UBALD2 Gene

miRTarBase miRNAs that target UBALD2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBALD2 Gene

Localization for UBALD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBALD2 gene
Compartment Confidence
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for UBALD2 Gene

Pathways & Interactions for UBALD2 Gene

SuperPathways for UBALD2 Gene

No Data Available

Interacting Proteins for UBALD2 Gene

Gene Ontology (GO) - Biological Process for UBALD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBALD2 Gene

Drugs & Compounds for UBALD2 Gene

No Compound Related Data Available

Transcripts for UBALD2 Gene

mRNA/cDNA for UBALD2 Gene

Unigene Clusters for UBALD2 Gene

UBA-like domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBALD2 Gene

No ASD Table

Relevant External Links for UBALD2 Gene

GeneLoc Exon Structure for
UBALD2
ECgene alternative splicing isoforms for
UBALD2

Expression for UBALD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBALD2 Gene

mRNA differential expression in normal tissues according to GTEx for UBALD2 Gene

This gene is overexpressed in Whole Blood (x11.8).

NURSA nuclear receptor signaling pathways regulating expression of UBALD2 Gene:

UBALD2

SOURCE GeneReport for Unigene cluster for UBALD2 Gene:

Hs.744981

Evidence on tissue expression from TISSUES for UBALD2 Gene

  • Muscle(2.2)
genes like me logo Genes that share expression patterns with UBALD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBALD2 Gene

Orthologs for UBALD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBALD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBALD2 33 34
  • 99.39 (n)
cow
(Bos Taurus)
Mammalia UBALD2 33 34
  • 93.5 (n)
rat
(Rattus norvegicus)
Mammalia Ubald2 33
  • 91.62 (n)
mouse
(Mus musculus)
Mammalia Ubald2 33 16 34
  • 90.39 (n)
Gm7367 34
  • 90 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia UBALD2 34
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBALD2 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubald2 33
  • 75.81 (n)
Str.19931 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5480 33
zebrafish
(Danio rerio)
Actinopterygii ubald2 33 34
  • 70.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
OneToMany
Species where no ortholog for UBALD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBALD2 Gene

ENSEMBL:
Gene Tree for UBALD2 (if available)
TreeFam:
Gene Tree for UBALD2 (if available)

Paralogs for UBALD2 Gene

Paralogs for UBALD2 Gene

(2) SIMAP similar genes for UBALD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UBALD2: view

Variants for UBALD2 Gene

Sequence variations from dbSNP and Humsavar for UBALD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000114880 -- 76,268,774(+) TGCCA(A/C)CTAGG intron-variant
rs1000220434 -- 76,269,705(+) TGTGG(C/T)GTGAA intron-variant
rs1000977398 -- 76,264,733(+) AAGAT(G/T)TTTTT nc-transcript-variant, upstream-variant-2KB
rs1001185954 -- 76,267,613(+) CCTCC(C/T)GAAGT intron-variant
rs1001323081 -- 76,268,019(+) CTAGA(A/G)ACCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBALD2 Gene

Variant ID Type Subtype PubMed ID
esv3641280 CNV loss 21293372
nsv828104 CNV loss 20364138
nsv833547 CNV loss 17160897

Variation tolerance for UBALD2 Gene

Gene Damage Index Score: 0.11; 2.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBALD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBALD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBALD2 Gene

Disorders for UBALD2 Gene

Relevant External Links for UBALD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBALD2

No disorders were found for UBALD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBALD2 Gene

Publications for UBALD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 60
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for UBALD2 Gene

Sources for UBALD2 Gene

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