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UBALD1 Gene

protein-coding   GIFtS: 34
GCID: GC16M004656

UBA-Like Domain Containing 1

(Previous names: family with sequence similarity 100, member A)
(Previous symbol: FAM100A)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UBA-Like Domain Containing 11 2
FAM100A1 2 3
Family With Sequence Similarity 100, Member A1 2
Protein FAM100A2
UBA-Like Domain-Containing Protein 12

External Ids:    HGNC: 295761   Entrez Gene: 1244022   Ensembl: ENSG000001534437   UniProtKB: Q8TB053   

Export aliases for UBALD1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UBALD1 Gene:
UBALD1 (UBA-like domain containing 1) is a protein-coding gene. An important paralog of this gene is UBALD2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for UBALD1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBALD1 promoter sequence
   Search Chromatin IP Primers for UBALD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBALD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

UBALD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBALD1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004656:  view genomic region     (about GC identifiers)

Start:
4,658,884 bp from pter      End:
4,665,028 bp from pter
Size:
6,145 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBAD1_HUMAN, Q8TB05 (See protein sequence)
Recommended Name: UBA-like domain-containing protein 1  
Size: 177 amino acids; 18954 Da
Secondary accessions: Q71MF6
Alternative splicing: 2 isoforms:  Q8TB05-1   Q8TB05-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBALD1: NX_Q8TB05

Explore proteomics data for UBALD1 at MOPED


See UBALD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_660296.1  
ENSEMBL proteins: 
 ENSP00000465706   ENSP00000466361   ENSP00000467671   ENSP00000283474   ENSP00000464725  
 ENSP00000465041   ENSP00000466404   ENSP00000465745   ENSP00000465847  

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antibodies-online proteins for UBALD1 (4 products) 

 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR009060 UBA-like

Graphical View of Domain Structure for InterPro Entry Q8TB05

ProtoNet protein and cluster: Q8TB05

UniProtKB/Swiss-Prot: UBAD1_HUMAN, Q8TB05
Similarity: Belongs to the UBALD family


Find genes that share domains with UBALD1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with UBALD1           About GenesLikeMe


Phenotypes:
     3 GenomeRNAi human phenotypes for UBALD1:
 Decreased Wnt reporter activit  Decreased viability with pacli  Increased gamma-H2AX phosphory 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for UBALD1

miRNA
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miRTarBase miRNAs that target UBALD1:
hsa-mir-23a-3p (MIRT050440)

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Sino Biological Human cDNA Clone for UBALD1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBALD1

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBALD1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBALD1
Interactions:

    Search GeneGlobe Interaction Network for UBALD1

5 Interacting proteins for UBALD1 (Q8TB053) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
RPL9P329693I2D: score=3 
RPL9P7P329693I2D: score=3 
RPL9P8P329693I2D: score=3 
RPL9P9P329693I2D: score=3 
MED8Q96G253I2D: score=3 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for UBALD1 (UBAD1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for UBALD1 gene: 
NM_145253.2  

Unigene Cluster for UBALD1:

UBA-like domain containing 1
Hs.513313  [show with all ESTs]
Unigene Representative Sequence: AK123636
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000590891 ENST00000590965 ENST00000591401 ENST00000283474(uc002cwx.2)
ENST00000591897 ENST00000588691 ENST00000587615 ENST00000587649 ENST00000591113

miRNA
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat UBALD1
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  QuantiFast Probe-based Assays in human, mouse, rat UBALD1

Additional mRNA sequence: 

AF370434.1 AK055785.1 AK056747.1 AK123636.1 BC008681.1 BC012018.1 BC025327.1 BC040160.1 
BC062534.1 

8 DOTS entries:

DT.91979584  DT.91702998  DT.95269094  DT.95320502  DT.100693593  DT.102824868  DT.102824870  DT.75154845 

Selected AceView cDNA sequences (see all 121):

BM673763 AI926801 AW015675 BQ669438 CR608937 BE856719 F37812 AI801861 
BM785544 AA679059 AA701309 AA482549 AI961676 BM677675 NM_145253 BQ061245 
BQ887900 AI417947 BM765099 AA285012 BQ962361 BI962821 BC025327 AF447881 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBALD1 (see all 6)    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
SP1:        -     -     -     -     -                                             
SP2:                    -     -     -                                             
SP3:                    -     -                                                   
SP4:                    -     -     -                 -                           
SP5:                                -                                             


ECgene alternative splicing isoforms for UBALD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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UBALD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
UBALD1 Expression
About this image

UBALD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

UBALD1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.513313
    Custom PCR Arrays for UBALD1
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBALD1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for UBALD1 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ubald11 , 5 family with sequence similarity 100, member A5
UBA-like domain containing 11
90.67(n)1
93.14(a)1
  16 (2.48 cM)5
2077401  NM_145359.21  NP_663334.11 
 48747785 
chicken
(Gallus gallus)
Aves FAM100A1 family with sequence similarity 100, member A 68.14(n)
66.18(a)
  416661  XM_414958.4  XP_414958.4 
zebrafish
(Danio rerio)
Actinopterygii Dr.147522 Transcribed sequences 74.14(n)    CF998871.1 


ENSEMBL Gene Tree for UBALD1 (if available)
TreeFam Gene Tree for UBALD1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for UBALD1 gene
UBALD22  
2 SIMAP similar genes for UBALD1 using alignment to 6 protein entries:     UBAD1_HUMAN (see all proteins):
FAM100A    UBALD2

Find genes that share paralogs with UBALD1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for UBALD1 (see all 202)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1460172391,2
--4625509(+) AGGCCA/GGGCTC 1 -- int10--------
rs1895124711,2
--4625537(+) CCCAGA/CCACTG 1 -- int10--------
rs1929690391,2
--4625547(+) GGAGCC/TGAGAC 1 -- int10--------
rs22794081,2
C,F,A,H--4625571(+) GAGATA/GAAACC 1 -- int124Minor allele frequency- G:0.28EA NS NA WA 4006
rs1147032511,2
F--4625600(+) GTGTGA/GGCCCT 1 -- int11Minor allele frequency- G:0.02WA 118
rs1399921401,2
C--4625737(+) AGCACA/GCTGTG 1 -- int10--------
rs1417412381,2
--4625784(+) GAGGCG/TCGGGG 1 -- int10--------
rs794112611,2
C,F--4625785(+) AGGCTC/TGGGGT 1 -- int11Minor allele frequency- T:0.05NA 120
rs595912761,2
C--4625823(+) AGAACC/GAGCTG 1 -- int10--------
rs116414191,2
C,H--4626254(+) GGCCCC/TCAAGG 1 -- ut310--------

HapMap Linkage Disequilibrium report for UBALD1 (4658884 - 4665028 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for UBALD1: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing UBALD1
DNA2.0 Custom Variant and Variant Library Synthesis for UBALD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for UBALD1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with UBALD1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
  5. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 124402 HGNC: 29576 AceView: LOC124402 Ensembl:ENSG00000153443 euGenes: HUgn124402
ECgene: UBALD1 H-InvDB: UBALD1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for UBALD1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for UBALD1 gene:
Search GeneIP for patents involving UBALD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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