Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UBAC2 Gene

protein-coding   GIFtS: 53
GCID: GC13P099852

UBA Domain Containing 2

(Previous name: phosphoglycerate dehydrogenase like 1)
(Previous symbol: PHGDHL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
UBA Domain Containing 21 2     UBA Domain-Containing Protein 22 3
PHGDHL11 2 3     RP11-178C10.12
Phosphoglycerate Dehydrogenase Like 11 2     Ubiquitin-Associated Domain-Containing Protein 22
Phosphoglycerate Dehydrogenase-Like Protein 12 3     

External Ids:    HGNC: 204861   Entrez Gene: 3378672   Ensembl: ENSG000001348827   UniProtKB: Q8NBM43   

Export aliases for UBAC2 gene to outside databases

Previous GC identifers: GC13P098652 GC13P080447


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for UBAC2 Gene:
UBAC2 (UBA domain containing 2) is a protein-coding gene. Diseases associated with UBAC2 include behcet's disease, and basal cell carcinoma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000013.11  NT_009952.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBAC2 gene promoter:
         Zic1   COMP1   HSF1 (long)   HSF1short   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBAC2 promoter sequence
   Search Chromatin IP Primers for UBAC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBAC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.3   Ensembl cytogenetic band:  13q32.3   HGNC cytogenetic band: 13q32.3

UBAC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBAC2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P099852:  view genomic region     (about GC identifiers)

Start:
99,852,679 bp from pter      End:
100,038,753 bp from pter
Size:
186,075 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for UBAC2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UBAC2_HUMAN, Q8NBM4 (See protein sequence)
Recommended Name: Ubiquitin-associated domain-containing protein 2 precursor  
Size: 344 amino acids; 38964 Da
Sequence caution: Sequence=AAH72674.1; Type=Erroneous initiation; Sequence=AAI21139.1; Type=Erroneous initiation;
Secondary accessions: B3KNV7 Q0VAB5 Q5W0W6 Q5W0W9 Q6GQR2 Q6P4B0 Q8N2E8 Q96NW2
Alternative splicing: 5 isoforms:  Q8NBM4-1   Q8NBM4-2   Q8NBM4-3   Q8NBM4-4   Q8NBM4-5   

Explore the universe of human proteins at neXtProt for UBAC2: NX_Q8NBM4

Explore proteomics data for UBAC2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn161
  • Modification sites at PhosphoSitePlus

  • See UBAC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137544.1  NP_808882.1  

    ENSEMBL proteins: 
     ENSP00000347928   ENSP00000383911   ENSP00000365623   ENSP00000402249  

    UBAC2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for UBAC2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UBAC2
    GenScript Custom Purified and Recombinant Proteins Services for UBAC2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    UBAC2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UBAC2
    Novus Biologicals UBAC2 Antibodies
    Abcam antibodies for UBAC2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for UBAC2
    LSBio Antibodies in human, mouse, rat for UBAC2

    UBAC2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBAC2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBAC2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR009060 UBA-like
     IPR000449 UBA/Ts_N
     IPR015940 UBA/transl_elong_EF1B_N_euk

    Graphical View of Domain Structure for InterPro Entry Q8NBM4

    ProtoNet protein and cluster: Q8NBM4

    1 Blocks protein domain: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: UBAC2_HUMAN, Q8NBM4
    Similarity: Contains 1 UBA domain


    UBAC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    UBAC2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for UBAC2:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased cell death HMECs cel 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBAC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBAC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBAC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBAC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBAC2:
    hsa-mir-484 (MIRT041748), hsa-mir-1 (MIRT024047), hsa-mir-92a-3p (MIRT049669)

    Block miRNA regulation of human, mouse, rat UBAC2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate UBAC2:
    hsa-miR-4303 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548p hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidUBAC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBAC2
    Predesigned siRNA for gene silencing in human, mouse, rat UBAC2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBAC2

    Clone
    Products:
         
    OriGene clones in human, mouse for UBAC2 (see all 12)
    OriGene ORF clones in mouse, rat for UBAC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UBAC2 (NM_177967)
    Sino Biological Human cDNA Clone for UBAC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBAC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBAC2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBAC2
    Browse ESI BIO Cell Lines and PureStem Progenitors for UBAC2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBAC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UBAC2_HUMAN, Q8NBM4: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0016021integral component of membrane IEA--

    UBAC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBAC2
    Interactions:

        Search GeneGlobe Interaction Network for UBAC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for UBAC2 (Q8NBM42, 3 ENSP000003839114) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GET4Q7L5D62, 3, ENSP000002658574MINT-65706 I2D: score=4 STRING: ENSP00000265857
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    LMO7Q8WWI13, ENSP000003421124I2D: score=3 STRING: ENSP00000342112
    MMEP084733I2D: score=2 
    FAF2ENSP000002619424STRING: ENSP00000261942
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070972protein localization to endoplasmic reticulum IDA--

    UBAC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBAC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UBAC2 gene (2 alternative transcripts): 
    NM_001144072.1  NM_177967.3  

    Unigene Cluster for UBAC2:

    UBA domain containing 2
    Hs.508545  [show with all ESTs]
    Unigene Representative Sequence: NR_026644
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355700 ENST00000403766 ENST00000468067 ENST00000473091 ENST00000376440(uc001voa.4 uc010tiu.2 uc001vob.4 uc010tiv.2 uc001vod.3 uc001voc.3 uc010tiw.2)
    ENST00000457666 ENST00000494576(uc001voh.3) ENST00000473194 ENST00000460562
    ENST00000480738 ENST00000474510
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UBAC2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate UBAC2:
    hsa-miR-4303 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548p hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidUBAC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UBAC2
    Predesigned siRNA for gene silencing in human, mouse, rat UBAC2
    Clone
    Products:
         
    OriGene clones in human, mouse for UBAC2 (see all 12)
    OriGene ORF clones in mouse, rat for UBAC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UBAC2 (NM_177967)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBAC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBAC2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UBAC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBAC2
      QuantiTect SYBR Green Assays in human, mouse, rat UBAC2
      QuantiFast Probe-based Assays in human, mouse, rat UBAC2

    Additional mRNA sequence: 

    AF339812.1 AK054563.1 AK055110.1 AK075419.1 AK075516.1 AK124404.1 AK129861.1 AK290342.1 
    AK300908.1 BC053346.1 BC063559.1 BC072674.1 BC121138.1 BC121139.1 BC143265.1 NR_026644.1 

    Selected DOTS entries (see all 25):

    DT.308044  DT.100053302  DT.100689946  DT.92444187  DT.120766107  DT.95357803  DT.100059925  DT.100059933 
    DT.100689974  DT.100856863  DT.319660  DT.95071980  DT.120766033  DT.120766190  DT.100837233  DT.120765992 
    DT.120766158  DT.120766203  DT.120766214  DT.120766145  DT.120766224  DT.92444190  DT.95357923  DT.100645794 

    Selected AceView cDNA sequences (see all 455):

    BQ063199 BU171737 BU177950 BQ685545 BM765503 AL711083 CF140199 BQ574816 
    BQ687871 BQ013326 CB145408 BU538042 AA564676 AI866141 BM023283 BQ051917 
    BM840865 BX395933 BX387048 AA476667 BM765579 BQ950416 AW002178 BU185198 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBAC2 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ·
    SP1:                                            -     -     -           -                       -     -           -                                             
    SP2:                                            -     -                 -     -                 -     -     -     -           -                                 
    SP3:        -     -     -     -     -     -     -     -     -           -                             -     -     -                                             
    SP4:                                            -     -     -           -     -     -     -     -     -           -                                             
    SP5:                                                        -           -     -     -     -     -     -           -                                             

    ExUns: 14c ^ 15 ^ 16
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for UBAC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UBAC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGACCCG
    UBAC2 Expression
    About this image

    UBAC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBAC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508545
        Custom PCR Arrays for UBAC2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for UBAC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBAC2
    QuantiTect SYBR Green Assays in human, mouse, rat UBAC2
    QuantiFast Probe-based Assays in human, mouse, rat UBAC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBAC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBAC2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubac21 , 5 ubiquitin associated domain containing 21, 5 86.63(n)1
    89.24(a)1
      14 (65.78 cM)5
    688891  NM_026861.21  NP_081137.21 
     1218786065 
    chicken
    (Gallus gallus)
    Aves UBAC21 UBA domain containing 2 76.58(n)
    80.76(a)
      418778  NM_001006268.1  NP_001006268.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBAC26
    UBA domain containing 2
    78(a)
    1 ↔ 1
    3(98759126-98870623)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377329332   -- 75.12(n)    137732933 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1586451 zgc:158645 65.89(n)
    64.62(a)
      556047  NM_001080561.1  NP_001074030.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G411601 AT2G41160 43.43(n)
    32.85(a)
      818715  NM_180015.3  NP_850346.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02688001 Os01g0268800 43.65(n)
    31.67(a)
      4326264  NM_001049229.1  NP_001042694.1 


    ENSEMBL Gene Tree for UBAC2 (if available)
    TreeFam Gene Tree for UBAC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UBAC2 gene
    1 SIMAP similar gene for UBAC2 using alignment to 2 protein entries:     UBAC2_HUMAN (see all proteins):
    PHGDHL1

    UBAC2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UBAC2
    PGOHUM00000249959


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UBAC2 (see all 3029)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs602193251,2
    C--80527495(+) TCTCT-/CTTTCTC 3 -- int11Minor allele frequency- CT:0.00NA 2
    rs1131313011,2
    C--80847032(+) AAGAA-/ACACAAA 3 -- int11Minor allele frequency- AC:0.00CSA 2
    rs1811194341,2
    --99855051(+) TGTGTA/CTTACA 3 -- int10--------
    rs21828851,2
    C,F,A,H--99855124(+) ATGCAG/ACAACG 3 -- int125Minor allele frequency- A:0.35NS EA NA WA 2770
    rs1419155911,2
    C--99855278(+) TTTAT-/TTTA  
            
    TTTAT
    3 -- int10--------
    rs1508545011,2
    --99855278(+) TTTAT-/TTT   
       ATTTA
    TTTAT
    3 -- int10--------
    rs711184651,2
    C--99855279(-) ATCTC-/AATAAATA/
    AATAAATAAATA
    AATAA
    5 -- int1 cds11NA 2
    rs95176481,2
    C,A,H--99855313(+) TATTGG/AGATGG 3 -- int13Minor allele frequency- A:0.17NA WA 6
    rs1181801181,2
    C,F--99855349(+) TGCAGT/CGGTGG 3 -- int11Minor allele frequency- C:0.03NA 120
    rs1861393601,2
    --99855402(+) TCTCCC/TGCCTC 3 -- int10--------

    HapMap Linkage Disequilibrium report for UBAC2 (99852679 - 100038753 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for UBAC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521902CNV Loss19592680
    nsv523519CNV Loss19592680
    dgv1783n71CNV Loss21882294
    esv8421OTHER Inversion19470904

    Human Gene Mutation Database (HGMD): UBAC2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBAC2
    DNA2.0 Custom Variant and Variant Library Synthesis for UBAC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    8 diseases for UBAC2:    About MalaCards
    behcet's disease    basal cell carcinoma    bipolar disorder    inflammatory bowel disease
    schizophrenia    squamous cell carcinoma    prostate cancer    prostatitis


    UBAC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UBAC2
    Human Genome Epidemiology (HuGE) Navigator: UBAC2 (2 documents)

    Export disorders for UBAC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UBAC2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with UBAC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. (PubMed id 23760507)1 Lloyd S.J....Espenshade P.J. (J. Biol. Chem. 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Replication study confirms the association between UBAC2 and BehAset's disease in two independent Chinese sets of patients and controls. (PubMed id 22455605)1 Hou S....Yang P. (amp 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 337867 HGNC: 20486 AceView: PHGDHL1 Ensembl:ENSG00000134882 euGenes: HUgn337867
    ECgene: UBAC2 H-InvDB: UBAC2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UBAC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UBAC2 gene:
    Search GeneIP for patents involving UBAC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UBAC2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for UBAC2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UBAC2  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBAC2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UBAC2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBAC2   OriGene Custom Protein Services for UBAC2  

     
     
     Block miRNA regulation of human, mouse, rat UBAC2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UBAC2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBAC2 Predesigned siRNA for gene silencing in human, mouse, rat UBAC2
     QuantiFast Probe-based Assays in human, mouse, rat UBAC2 QuantiTect SYBR Green Assays in human, mouse, rat UBAC2
     Custom PCR Arrays for UBAC2 Search Chromatin IP Primers for UBAC2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBAC2  Search GeneGlobe Interaction Network for UBAC2
     Regulatory tfbs in UBAC2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UBAC2 GenScript cDNA clones with any tag delivered in your preferred vector for UBAC2
     GenScript Custom Assay Services for UBAC2 GenScript Custom overexpressing Cell Line Services for UBAC2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UBAC2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for UBAC2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UBAC2 antibodies
     Antibodies for UBAC2
     See all of Abcam's Antibodies, Kits and Proteins for UBAC2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for UBAC2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBAC2
     SwitchGear 3'UTR luciferase reporter plasmids for UBAC2
     SwitchGear Promoter luciferase reporter plasmids for UBAC2
     ThermoFisher Antibodies for UBAC2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBAC2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBAC2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBAC2
     LSBio Antibodies in human, mouse, rat for UBAC2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBAC2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4