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UBAC2 Gene

protein-coding GIFtS: 43

GC13P098652

UBA domain containing 2
(Previous name: phosphoglycerate dehydrogenase like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PHGDHL1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ26351 ^²
FLJ30001 ^²
FLJ30548 ^¹, ²
FLJ42413 ^²
MGC90487 ^²
OTTHUMP00000018615 ^²
OTTHUMP00000040721 ^²
PHGDHL1 ^², ³
RP11-178C10.1 ^¹, ²

Descriptions
Phosphoglycerate dehydrogenase-like protein 1 ^³
UBA domain containing 2 ^²
phosphoglycerate dehydrogenase like 1 ^¹, ²

External Ids
HGNC: 20486¹
Entrez Gene: 337867²
UniProtKB: Q8NBM4³
Ensembl: ENSG00000134882⁷

Search outside databases for aliases for UBAC2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.3 Ensembl cytogenetic band: 13q32.3 HGNC chromosome: 13

UBAC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P098652: (about GC identifiers)

Start:	98,651,029 bp from pter
End:	98,836,682 bp from pter
Size:	185,654 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000013.9 NT_009952.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBAC2_HUMAN, Q8NBM4 (See protein sequence)

Recommended Name: Ubiquitin-associated domain-containing protein 2 precursor

Size: 344 amino acids; 38964 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: B3KNV7 Q0VAB5 Q5W0W6 Q5W0W9 Q6GQR2 Q6P4B0 Q8N2E8 Q96NW2

Alternative splicing: 5 isoforms: Q8NBM4-1 Q8NBM4-2 Q8NBM4-3 Q8NBM4-4 Q8NBM4-5

REFSEQ proteins (2 alternative transcripts):

NP_001137544.1 NP_808882.1

ENSEMBL proteins:

ENSP00000365618 ENSP00000317007 ENSP00000347928 ENSP00000383911 ENSP00000365623

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for UBAC2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UBAC2
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for UBAC2

Assays for UBAC2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8NBM4

ProtoNet protein and cluster: Q8NBM4

1 Blocks protein family: IPB000449 Ubiquitin-associated domain

UniProtKB/Swiss-Prot: UBAC2_HUMAN, Q8NBM4

Similarity: Contains 1 UBA domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBAC2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001144072

Applied Biosystems Silencer® siRNAs for UBAC2

Sigma-Aldrich siRNA and siRNA Panels for UBAC2

Sigma-Aldrich shRNA for UBAC2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001144072
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001144072
untagged cDNA clones in CMV expression vector (see all 2): NM_001144072

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001144072

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Interacting proteins for UBAC2 (Q8NBM4²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
-- Q9UFC9² MINT-65706
-- Q5TBK5² MINT-64507
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBAC2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBAC2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001144072

Sigma-Aldrich siRNA and siRNA Panels for UBAC2

Sigma-Aldrich shRNA for UBAC2

Explore Sigma-Aldrich super-pooled esiRNAs

REFSEQ mRNAs for UBAC2 gene (2 alternative transcripts):

NM_001144072.1 NM_177967.3

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001144072
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001144072
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001144072

Additional cDNA sequence:

AF339812.1 AK054563.1 AK055110.1 AK075419.1 AK075516.1 AK124404.1 AK129861.1 AK290342.1

AK300908.1 BC053346.1 BC063559.1 BC072674.1 BC121138.1 BC121139.1 BC143265.1 CR611931.1

24/26 DOTS entries (see all 26 ):

DT.308044 DT.100053302 DT.100689946 DT.92444187 DT.120766107 DT.95357803 DT.100059925 DT.100059933

DT.100689974 DT.100856863 DT.319660 DT.95071980 DT.120766033 DT.120766190 DT.95296291 DT.100837233

DT.120765992 DT.120766158 DT.120766203 DT.120766214 DT.100645794 DT.120766145 DT.120766224 DT.92425917

24/455 AceView cDNA sequences (see all 455 ):

BQ685932 BM840865 BM669559 AI476008 BU845782 AL522301 AW518909 BX387048

AW002178 BQ933140 BQ687871 BQ063199 AK129861 BU931687 CA423596 CB145408

BX336526 BM743421 BQ683912 BQ676576 BM469334 BU845749 BQ637662 BU947529

Unigene Cluster for UBAC2:

UBA domain containing 2

Hs.508545 [show with all ESTs]

Unigene Representative Sequence: NM_001144072

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for UBAC2 (see all 12 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	·	2g	·	2h	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14a	·	14b	·
SP1:															-		-		-				-								-		-				-
SP2:															-		-						-		-						-		-		-		-				-
SP3:			-		-		-		-		-		-		-		-		-				-										-		-		-
SP4:															-		-		-				-		-		-		-		-		-				-
SP5:																			-				-		-		-		-		-		-				-

ExUns:	14c	^	15	^	16
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for UBAC2

5 Ensembl transcripts including schematic representations:

ENST00000376435 ENST00000325028 ENST00000355700 ENST00000403766 ENST00000376440

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBAC2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBAC2

¹ / ²

3 probe-sets matching UBAC2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57064_at²	U95-B	1	1.00	1.00	1.00	1.00	--	--	--	--	--
224298_s_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
224298_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAAAGACCCG

SOURCE GeneReport for Unigene cluster: Hs.508545

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBAC2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBAC2¹	--	UBA domain containing 2	90.97(n) 91.12(a)	608309 XM_844791.1 XP_849884.1
chimpanzee (Pan troglodytes)	UBAC2¹	--	UBA domain containing 2	96.15(n) 95.56(a)	740191 XM_001142071.1 XP_001142071.1
rat (Rattus norvegicus)	Phgdhl1¹	--	phosphoglycerate dehydrogenase like 1	84.85(n) 86.36(a)	361094 NM_001034937.1 NP_001030109.1
mouse (Mus musculus)	Ubac2^{1, 5}	14⁵	ubiquitin associated domain containing 2^{1, 5}	83.48(n)¹ 84.65(a)¹	68889¹ NM_026861.2¹ NP_081137.2¹ AK004517⁵ AK035384⁵ (see all 17)
chicken (Gallus gallus)	UBAC2¹	--	UBA domain containing 2	76.64(n) 80.37(a)	418778 NM_001006268.1 NP_001006268.1

About this table Species with no ortholog for UBAC2

ENSEMBL Gene Tree for UBAC2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/919 NCBI SNPs in UBAC2 are shown (see all 919 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 318)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1058083^1,2	A,C,F,H,O	98836234(+)	`TATCCG/AGAGTT`	1	--	ut3¹ ese³		17		EA MN NA EU WA	3006
	rs2296860^1,2	A,C,F,H	98650754(+)	`TTAGAA/GGTGGC`	1	--	ng5¹		7		EA EU WA NA	2096
	rs1058143^1,2	A,C,F,H	98836337(+)	`TGGCAC/TGGGCT`	1	--	ut3¹		10		EA MN EU WA NA	2038
--	rs9557176^1,2	A,C,F,H	98649805(+)	`TCTACG/CAATCA`	1	--	ng5¹		8		EU EA WA NA	600
	rs701537^1,2	A,C,F	98836272(+)	`TGGAGA/TAGAAC`	1	--	ut3¹ ese³		8		EA MN NA	2082
	rs2296044^1,2	C,F,H	98836826(-)	`CAGGAA/GCAAAA`	1	--	ng3¹		13		EA NA EU WA	2492
	rs9300541^1,2	C,H	98836788(+)	`TCAGAA/CGACTG`	1	--	ng3¹		3		EU EA	292
	rs2296045^1,2	F,H	98836033(-)	`AAAAAA/GCAGTA`	1	--	ut3¹ ese³ trp³		4		EU EA WA	410
	rs7332516^1,2	A	98651226(+)	`CTGCCC/GCCTAC`	1	--	ut5¹ ese³		0	--	--	--	--
	rs7338947^1,2	C	98651444(+)	`GGTGCG/TCTGCC`	1	--	ut5¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for UBAC2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Genome Epidemiology Navigator: UBAC2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for UBAC2 gene:

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PubMed id 16303743)^{3, 4} Otsuki T....Isogai T. (2005)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{3, 4} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia. (PubMed id 11991713)³ Christian S.L....Gershon E.S. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 337867	HGNC: 20486	AceView: PHGDHL1	Ensembl:ENSG00000134882	euGenes: HUgn337867
ECgene: UBAC2	H-InvDB: UBAC2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for UBAC2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for UBAC2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBAC2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBAC2		Antibodies for UBAC2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBAC2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for UBAC2

Search Tocris compounds for UBAC2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for UBAC2

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UBAC2 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for UBAC2

Summaries
for UBAC2

Genomic Location
for UBAC2

Proteins
for UBAC2

Protein Domains/
Families
for UBAC2

Gene Function
for UBAC2

Pathways & Interactions
for UBAC2

Drugs & Compounds
for UBAC2

Transcripts
for UBAC2

Expression
for UBAC2

Orthologs
for UBAC2

Paralogs
for UBAC2

SNPs/Variants
for UBAC2

Disorders & Mutations
for UBAC2

Medical News
for UBAC2

Publications
for UBAC2

Search for UBAC2

Genome Databases showing UBAC2

Other Databases showing UBAC2

Specialized Databases showing UBAC2

Licensable Technologies
for UBAC2

Services
for UBAC2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBAC2 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor UBAC2

Summariesfor UBAC2

Genomic Locationfor UBAC2

Proteinsfor UBAC2

Protein Domains/Familiesfor UBAC2

Gene Functionfor UBAC2

Pathways & Interactionsfor UBAC2

Drugs & Compoundsfor UBAC2

Transcriptsfor UBAC2

Expression for UBAC2

Orthologsfor UBAC2

Paralogsfor UBAC2

SNPs/Variantsfor UBAC2

Disorders & Mutationsfor UBAC2

Medical Newsfor UBAC2

Publicationsfor UBAC2

Search for UBAC2

Genome Databases showing UBAC2

Other Databases showing UBAC2

Specialized Databases showing UBAC2

Licensable Technologiesfor UBAC2

Servicesfor UBAC2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBAC2

Summaries
for UBAC2

Genomic Location
for UBAC2

Proteins
for UBAC2

Protein Domains/
Families
for UBAC2

Gene Function
for UBAC2

Pathways & Interactions
for UBAC2

Drugs & Compounds
for UBAC2

Transcripts
for UBAC2

Expression
for UBAC2

Orthologs
for UBAC2

Paralogs
for UBAC2

SNPs/Variants
for UBAC2

Disorders & Mutations
for UBAC2

Medical News
for UBAC2

Publications
for UBAC2

Licensable Technologies
for UBAC2

Services
for UBAC2