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Aliases for UBAC1 Gene

Aliases for UBAC1 Gene

  • UBA Domain Containing 1 2 3 5
  • Glialblastoma Cell Differentiation-Related Protein 1 3 4
  • Kip1 Ubiquitination-Promoting Complex Protein 2 3 4
  • Ubiquitin Associated Domain Containing 1 2 3
  • E3 Ubiquitin-Protein Ligase Subunit KPC2 3 4
  • UBA Domain-Containing Protein 1 3 4
  • UBADC1 3 4
  • GBDR1 3 4
  • Putative Glialblastoma Cell Differentiation-Related Protein 3
  • Testicular Secretory Protein Li 64 3
  • KPC2 4

External Ids for UBAC1 Gene

Previous HGNC Symbols for UBAC1 Gene

  • UBADC1

Previous GeneCards Identifiers for UBAC1 Gene

  • GC09M137965
  • GC09M138824
  • GC09M108286

Summaries for UBAC1 Gene

GeneCards Summary for UBAC1 Gene

UBAC1 (UBA Domain Containing 1) is a Protein Coding gene. Diseases associated with UBAC1 include acute cystitis and bladder disease. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation.

UniProtKB/Swiss-Prot for UBAC1 Gene

  • Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Gene Wiki entry for UBAC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBAC1 Gene

Genomics for UBAC1 Gene

Regulatory Elements for UBAC1 Gene

Promoters for UBAC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBAC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBAC1 Gene

Chromosome:
9
Start:
135,932,969 bp from pter
End:
135,961,380 bp from pter
Size:
28,412 bases
Orientation:
Minus strand

Genomic View for UBAC1 Gene

Genes around UBAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBAC1 Gene

Proteins for UBAC1 Gene

  • Protein details for UBAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSL1-UBAC1_HUMAN
    Recommended name:
    Ubiquitin-associated domain-containing protein 1
    Protein Accession:
    Q9BSL1
    Secondary Accessions:
    • O75500
    • Q9UMW7

    Protein attributes for UBAC1 Gene

    Size:
    405 amino acids
    Molecular mass:
    45338 Da
    Quaternary structure:
    • Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with RNF123 via its N-terminal domain. Interacts with the proteasome via its N-terminal domain.
    SequenceCaution:
    • Sequence=AAC21559.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBAC1 Gene

neXtProt entry for UBAC1 Gene

Proteomics data for UBAC1 Gene at MOPED

Post-translational modifications for UBAC1 Gene

  • Ubiquitination at Lys 7, Lys 154, and Lys 305
  • Modification sites at PhosphoSitePlus

Other Protein References for UBAC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for UBAC1

No data available for DME Specific Peptides for UBAC1 Gene

Domains & Families for UBAC1 Gene

Protein Domains for UBAC1 Gene

Suggested Antigen Peptide Sequences for UBAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BSL1

UniProtKB/Swiss-Prot:

UBAC1_HUMAN :
  • Contains 1 STI1 domain.
Domain:
  • Contains 1 STI1 domain.
  • Contains 2 UBA domains.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBAC1: view

No data available for Gene Families for UBAC1 Gene

Function for UBAC1 Gene

Molecular function for UBAC1 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.
genes like me logo Genes that share phenotypes with UBAC1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBAC1 Gene

Localization for UBAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBAC1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBAC1 Gene COMPARTMENTS Subcellular localization image for UBAC1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
cytosol 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for UBAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with UBAC1: view

Pathways & Interactions for UBAC1 Gene

genes like me logo Genes that share pathways with UBAC1: view

UniProtKB/Swiss-Prot Q9BSL1-UBAC1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBAC1 Gene

None

No data available for SIGNOR curated interactions for UBAC1 Gene

Drugs & Compounds for UBAC1 Gene

No Compound Related Data Available

Transcripts for UBAC1 Gene

Unigene Clusters for UBAC1 Gene

UBA domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBAC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: -
SP7:

Relevant External Links for UBAC1 Gene

GeneLoc Exon Structure for
UBAC1
ECgene alternative splicing isoforms for
UBAC1

Expression for UBAC1 Gene

mRNA expression in normal human tissues for UBAC1 Gene

mRNA differential expression in normal tissues according to GTEx for UBAC1 Gene

This gene is overexpressed in Muscle - Skeletal (x7.2).

Protein differential expression in normal tissues from HIPED for UBAC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4) and Spleen (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBAC1 Gene



SOURCE GeneReport for Unigene cluster for UBAC1 Gene Hs.9194

mRNA Expression by UniProt/SwissProt for UBAC1 Gene

Q9BSL1-UBAC1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with UBAC1: view

Protein tissue co-expression partners for UBAC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for UBAC1 Gene

Orthologs for UBAC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBAC1 36
  • 99 (a)
OneToOne
UBAC1 35
  • 97.85 (n)
  • 97.28 (a)
cow
(Bos Taurus)
Mammalia UBAC1 35
  • 85.66 (n)
  • 88.06 (a)
UBAC1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBAC1 36
  • 91 (a)
OneToOne
UBAC1 35
  • 88.07 (n)
  • 92.1 (a)
mouse
(Mus musculus)
Mammalia Ubac1 16
Ubac1 36
  • 89 (a)
OneToOne
Ubac1 35
  • 85.1 (n)
  • 89.88 (a)
oppossum
(Monodelphis domestica)
Mammalia UBAC1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBAC1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubac1 35
  • 84.86 (n)
  • 89.63 (a)
chicken
(Gallus gallus)
Aves UBAC1 35
  • 76.54 (n)
  • 83.46 (a)
UBAC1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBAC1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7599 35
ubac1 35
  • 74.32 (n)
  • 80.49 (a)
zebrafish
(Danio rerio)
Actinopterygii ubac1 35
  • 71.28 (n)
  • 77.78 (a)
ubac1 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002436 35
  • 48.79 (n)
  • 34.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta isopeptidase-T-3 35
  • 45.32 (n)
  • 32.68 (a)
isopeptidase-T-3 36
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToOne
Species with no ortholog for UBAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBAC1 Gene

ENSEMBL:
Gene Tree for UBAC1 (if available)
TreeFam:
Gene Tree for UBAC1 (if available)

Paralogs for UBAC1 Gene

No data available for Paralogs for UBAC1 Gene

Variants for UBAC1 Gene

Sequence variations from dbSNP and Humsavar for UBAC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs11103231 - 135,933,496(+) GGGTT(C/G)TCCAG reference, missense
rs915236 -- 135,948,678(+) GGAGC(A/G)GGGCA intron-variant
rs2297688 -- 135,948,231(-) TGCAG(C/G)CTGGG intron-variant
rs2297689 -- 135,948,042(-) CCCCA(A/G)CTCAT intron-variant
rs2297690 -- 135,946,459(-) AGAAT(C/T)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBAC1 Gene

Variant ID Type Subtype PubMed ID
nsv831757 CNV Loss 17160897
dgv8372n71 CNV Loss 21882294
nsv825173 CNV Gain 20364138
nsv894278 CNV Loss 21882294
dgv8373n71 CNV Loss 21882294
dgv8374n71 CNV Loss 21882294
dgv8375n71 CNV Loss 21882294
nsv894285 CNV Gain 21882294
dgv8376n71 CNV Loss 21882294

Variation tolerance for UBAC1 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.97; 84.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBAC1 Gene

HapMap Linkage Disequilibrium report
UBAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBAC1 Gene

Disorders for UBAC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for UBAC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute cystitis
  • urinary tract infection
bladder disease
  • urinary bladder disease
- elite association - COSMIC cancer census association via MalaCards
Search UBAC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBAC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBAC1
genes like me logo Genes that share disorders with UBAC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBAC1 Gene

Publications for UBAC1 Gene

  1. Identification of a glialblastoma cell differentiation factor-related gene mRNA in human microvascular endothelial cells. (PMID: 10857748) Li C. … Banerjee D. (Genomics 2000) 2 3 4 23 67
  2. AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix. (PMID: 16310047) Tao Y. … Scheinman R.I. (Mol. Immunol. 2006) 3 23
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3

Products for UBAC1 Gene

Sources for UBAC1 Gene

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