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Aliases & Descriptions for UBAC1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| GBDR1 1, 2, 3, 5 | | KPC2 3 | | OTTHUMP00000022563 2 | | RP11-432J22.3 2 | | UBADC1 2, 3 |
| | | Descriptions |
|---|
| E3 ubiquitin-protein ligase subunit KPC2 3 | | Glialblastoma cell differentiation-related protein 1 3 | | Kip1 ubiquitination-promoting complex protein 2 3 | | UBA domain containing 1 2 | | UBA domain-containing protein 1 3 | | putative glialblastoma cell differentiation-related protein 2 | | ubiquitin associated domain containing 1 1, 2 |
|
| | Search outside databases for aliases for UBAC1 gene |
Summaries for UBAC1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: UBAC1_HUMAN, Q9BSL1Function: Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycleGene Wiki entry for UBAC1 |
Genomic Location for UBAC1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3UBAC1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M137965:
(about GC identifiers)
Start:
|
137,964,636 bp from pter |
End:
|
137,993,047 bp from pter |
Size:
|
28,412 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000009.10 NT_019501.13
| Proteins for UBAC1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: UBAC1_HUMAN, Q9BSL1 (See
protein sequence)Recommended Name: Ubiquitin-associated domain-containing protein 1 Size: 405 amino acids; 45338 Da
Subunit: Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with RNF123 via its N-terminal domain. Interacts with the proteasome via its N-terminal domain
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :2DAI (3D)
 
Secondary accessions: O75500 Q9UMW7REFSEQ proteins: NP_057256.2
ENSEMBL proteins: ENSP00000360821
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: UBAC1 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for UBAC1: Assays for UBAC1: | Protein
Domains/ Families for UBAC1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BSL1
ProtoNet protein and cluster: Q9BSL1 2 Blocks protein families: IPB000449 Ubiquitin-associated domain IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: UBAC1_HUMAN, Q9BSL1Similarity: Contains 1 STI1 domainSimilarity: Contains 2 UBA domainsSimilarity: Contains 1 ubiquitin-like domain | Gene Function for UBAC1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016172
Applied Biosystems Silencer® siRNAs for UBAC1
Sigma-Aldrich siRNA and siRNA Panels for UBAC1  Sigma-Aldrich shRNA for UBAC1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016172                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016172                                  untagged cDNA clone in CMV expression vector: NM_016172 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016172
UniProtKB/Swiss-Prot: UBAC1_HUMAN, Q9BSL1Function: Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for UBAC1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| UniProtKB/Swiss-Prot: UBAC1_HUMAN, Q9BSL1Pathway: Protein modification; protein ubiquitination 5/9 Interacting proteins for UBAC1 (ENSP000003608213 Q9BSL11) via UniProtKB, MINT, and/or STRING (see all 9
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019941 | modification-dependent protein catabolic process |
IEA | -- | About this table
|
Drugs & Compounds for UBAC1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for UBAC1
|
Transcripts for UBAC1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016172
Sigma-Aldrich siRNA and siRNA Panels for UBAC1  Sigma-Aldrich shRNA for UBAC1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016172 REFSEQ mRNAs for UBAC1 gene: NM_016172.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016172               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016172                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016172                                  untagged cDNA clone in CMV expression vector: NM_016172  Additional cDNA sequence: AF038200.1 AF068195.1 AF176796.1 BC004967.1 BC011822.1 BX647463.1 CR590831.1 CR591205.1 CR591593.1 CR592166.1 CR595884.1 CR599174.1 CR601673.1 CR603032.1 CR604883.1 CR609611.1 CR611514.1 CR611758.1 CR617611.1 CR619664.1 CR620351.1 CR626744.1 CR749573.1 13 DOTS entries: DT.455735 DT.100814058 DT.100723924 DT.92440857 DT.97804089 DT.92440852 DT.100814063 DT.100814067 DT.40107630 DT.92440855 DT.40107631 DT.95339608 DT.95339615 24/322 AceView cDNA sequences (see all 322
):CR611514 AW440073 CD370533 CR591593 BF940409 BX396681 BM541654 AA341788 AA865215 AA887336 AW440031 W23682 CR592166 BM552485 CR599174 CR601673 CB143740 CR620351 CR591205 CR603032 CR611758 F36708 BM467805 BM800247 Unigene Cluster for UBAC1: UBA domain containing 1 Hs.9194 [show with all ESTs]Unigene Representative Sequence: BX647463
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UBAC1 (see all 7
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | |
| SP1: | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for UBAC1
1 Ensembl transcript including schematic representation: ENST00000371756
|
Expression for UBAC1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBAC1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBAC1
1 / 2 3 probe-sets matching UBAC1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTAATTTAAC
SOURCE GeneReport for Unigene cluster: Hs.9194 UniProtKB/Swiss-Prot: UBAC1_HUMAN, Q9BSL1Tissue specificity: Ubiquitous |
Orthologs for UBAC1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBAC1 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for UBAC1
ENSEMBL Gene Tree for UBAC1 | Paralogs for UBAC1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for UBAC1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for UBAC1 (up to first 250kb)
|
Disorders & Mutations for UBAC1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608129
|
Medical News for UBAC1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for UBAC1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for UBAC1 gene (see all 13
):- Identification of a glialblastoma cell differentiation factor-related gene mRNA in human microvascular endothelial cells. (PubMed id 10857748)1, 2, 3, 4 Li C.... Banerjee D. (2000)
- Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase. (PubMed id 15746103)3, 4 Kotoshiba S.... Nakayama K. (2005)
- Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. (PubMed id 15531880)3, 4 Kamura T.... Nakayama K. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)3, 4 Humphray S.J.... Dunham I. (2004)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)2, 3 Andersson B....Gibbs R.A. (1996)
- AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix. (PubMed id 16310047)1, 3 Tao Y....Scheinman R.I. (2006)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)3 Rual J.F....Vidal M. (2005)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)3 Colland F....Gauthier J.M. (2004)
|
Search for UBAC1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBAC1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBAC1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBAC1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for UBAC1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for UBAC1:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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