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UBAC1 Gene

protein-coding   GIFtS: 49

GC09M137965
UBA domain containing 1
(Previous name: ubiquitin associated domain containing 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: UBADC1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
GBDR1 1, 2, 3, 5
KPC2 3
OTTHUMP00000022563 2
RP11-432J22.3 2
UBADC1 2, 3
Descriptions
E3 ubiquitin-protein ligase subunit KPC2 3
Glialblastoma cell differentiation-related protein 1 3
Kip1 ubiquitination-promoting complex protein 2 3
UBA domain containing 1 2
UBA domain-containing protein 1 3
putative glialblastoma cell differentiation-related protein 2
ubiquitin associated domain containing 1 1, 2
External Ids
HGNC: 302211
Entrez Gene: 104222
UniProtKB: Q9BSL13
Ensembl: ENSG000001305607
Search outside databases for aliases for UBAC1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UBAC1_HUMAN, Q9BSL1
Function: Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase.
Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of
the cell cycle

Gene Wiki entry for UBAC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

UBAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M137965:     (about GC identifiers)

Start:
137,964,636 bp from pter
End:
137,993,047 bp from pter
Size:
28,412 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000009.10  NT_019501.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: UBAC1_HUMAN, Q9BSL1 (See protein sequence)
Recommended Name: Ubiquitin-associated domain-containing protein 1  
Size: 405 amino acids; 45338 Da
Subunit: Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with RNF123
via its N-terminal domain. Interacts with the proteasome via its N-terminal domain
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
2DAI (3D)    
Secondary accessions: O75500 Q9UMW7

REFSEQ proteins: NP_057256.2  

ENSEMBL proteins: 
ENSP00000360821 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (UBADC1)
              OriGene Purified Recombinant Human Protein: UBAC1 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
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Antibodies for UBAC1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for UBAC1
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Monoclonal and Polyclonal Antibodies from Abnova (UBADC1)
Novus Biologicals Antibody for UBAC1

Assays for UBAC1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro domains/families:
 IPR006636 STI1_HS_bd
 IPR000449 UBA/transl_elong_EF1B_N
 IPR015940 UBA/transl_elong_EF1B_N_euk


   GeneDecks  UBAC1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9BSL1

ProtoNet protein and cluster: Q9BSL1

2 Blocks protein families:
IPB000449 Ubiquitin-associated domain
IPB000626 Ubiquitin domain


UniProtKB/Swiss-Prot: UBAC1_HUMAN, Q9BSL1
Similarity: Contains 1 STI1 domain
Similarity: Contains 2 UBA domains
Similarity: Contains 1 ubiquitin-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (UBAC1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016172

              Applied Biosystems Silencer® siRNAs for UBAC1

              Sigma-Aldrich siRNA and siRNA Panels for UBAC1  
                     Sigma-Aldrich shRNA for UBAC1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for UBAC1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016172
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_016172
                                 untagged cDNA clone in CMV expression vector: NM_016172 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_016172

UniProtKB/Swiss-Prot: UBAC1_HUMAN, Q9BSL1
Function: Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase.
Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of
the cell cycle

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IPI17353931
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


UniProtKB/Swiss-Prot: UBAC1_HUMAN, Q9BSL1
Pathway: Protein modification; protein ubiquitination


5/9 Interacting proteins for UBAC1 (ENSP000003608213 Q9BSL11) via UniProtKB, MINT, and/or STRING (see all 9 )

InteractantInteraction Details
GeneCardExternal ID(s)
DSPP159241EBI-749370, EBI-355041
EIF4EBP1Q135411EBI-749370, EBI-74090
IQGAP2Q135761EBI-749370, EBI-357571
MED7O435131EBI-749370, EBI-394632
MYH2Q9UKX21EBI-749370, EBI-1049626
About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0019941 modification-dependent protein catabolic process IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBAC1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (UBAC1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016172

              Sigma-Aldrich siRNA and siRNA Panels for UBAC1  
                     Sigma-Aldrich shRNA for UBAC1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_016172  

REFSEQ mRNAs for UBAC1 gene: 

NM_016172.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_016172  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016172
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_016172
                                 untagged cDNA clone in CMV expression vector: NM_016172 

Additional cDNA sequence: 

AF038200.1 AF068195.1 AF176796.1 BC004967.1 BC011822.1 BX647463.1 CR590831.1 CR591205.1 
CR591593.1 CR592166.1 CR595884.1 CR599174.1 CR601673.1 CR603032.1 CR604883.1 CR609611.1 
CR611514.1 CR611758.1 CR617611.1 CR619664.1 CR620351.1 CR626744.1 CR749573.1 

13 DOTS entries:

DT.455735  DT.100814058  DT.100723924  DT.92440857  DT.97804089  DT.92440852  DT.100814063  DT.100814067 
DT.40107630  DT.92440855  DT.40107631  DT.95339608  DT.95339615 

24/322 AceView cDNA sequences (see all 322 ):

CR611514 AW440073 CD370533 CR591593 BF940409 BX396681 BM541654 AA341788 
AA865215 AA887336 AW440031 W23682 CR592166 BM552485 CR599174 CR601673 
CB143740 CR620351 CR591205 CR603032 CR611758 F36708 BM467805 BM800247 

Unigene Cluster for UBAC1:

UBA domain containing 1
Hs.9194  [show with all ESTs]
Unigene Representative Sequence: BX647463


GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UBAC1 (see all 7 )

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1:                          -           -     -                 -                 -                                 
SP2:                          -           -     -                 -                                                   
SP3:                                      -     -                 -                                                   
SP4:                                                              -                 -           -                     
SP5:                          -           -                                                                           

About this scheme

ECgene alternative splicing isoforms for UBAC1

1 Ensembl transcript including schematic representation:
ENST00000371756  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBAC1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for UBAC1

1 / 2

3 probe-sets matching UBAC1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

38841_at2 U95-A 1 1.00 1.00 1.00 1.00 -- -- -- -- --

202151_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

202151_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CTAATTTAAC

SOURCE GeneReport for Unigene cluster: Hs.9194

UniProtKB/Swiss-Prot: UBAC1_HUMAN, Q9BSL1
Tissue specificity: Ubiquitous

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for UBAC1 gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
UBAC11   -- UBA domain containing 1 88.64(n)
93.33(a)
491256  XM_843897.1  XP_848990.1 
cow
(Bos taurus)
UBAC11   -- UBA domain containing 1 85.66(n)
88.06(a)
613652  NM_001076281.1  NP_001069749.1 
rat
(Rattus norvegicus)
Ubac11   -- UBA domain containing 1 85.56(n)
90.84(a)
362087  NM_001007742.1  NP_001007743.1 
mouse
(Mus musculus)
Ubac11, 5 25
ubiquitin associated domain containing 11, 5 85.43(n)1
90.62(a)1
987661  NM_133835.11  NP_598596.11 
 AA4079785  AI4507065  (see all 26)
chicken
(Gallus gallus)
UBAC11   -- UBA domain containing 1 76.79(n)
84.69(a)
427754  NM_001031474.1  NP_001026645.1 
About this table        Species with no ortholog for UBAC1

ENSEMBL Gene Tree for UBAC1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/139 NCBI SNPs in UBAC1 are shown (see all 139 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 85)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs65691,2
A,C,F,H,O137964938(-) GCAGCT/GGCTCC 1 -- ut31 ese37Minor allele frequency- G:0.49MN EA EU WA 2286
rs104483151,2
A,C,F,H137993584(+) GTCACT/GGTTCC 1 -- ng314Minor allele frequency- G:0.15EU EA WA 418
--
rs65379221,2
C,F,H137993207(+) TCTGGC/TAGCTT 1 -- ng314Minor allele frequency- T:0.01EU EA WA 420
--
rs108581911,2
A,C137994121(+) TAGACC/TTGACA 1 -- ng310--------
rs65379211,2
A,C137993145(+) GTGGCC/TACCGC 1 -- ng310--------
rs111032311,2
C,H137965163(+) GGGTTC/GTCCAG 1 E/D mis14Minor allele frequency- G:0.00EU EA WA 402
--
rs70244721,2
A137994205(+) TTCCCA/GTTCTC 1 -- ng310--------
rs111032301,2
A137964359(+) TTTTAA/CAATGA 1 -- ng510--------
--
rs38312581,2
C137976763(-) TGAGG-/AGGCCAGA 1 EA/A fra10--------
rs65379231,2
C137993226(+) CCCGAC/GCTGCA 1 -- ng310--------
About this table

HapMap Linkage Disequilibrium images for UBAC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608129

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/13 PubMed articles for UBAC1 gene (see all 13 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10422 HGNC: 30221 AceView: UBADC1 Ensembl:ENSG00000130560 euGenes: HUgn10422
ECgene: UBAC1 H-InvDB: UBAC1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for UBAC1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for UBAC1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for UBAC1 Antibodies for UBAC1
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for UBAC1 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 shRNA in GFP-retroviral vector
 Search Tocris compounds for UBAC1




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for UBAC1

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