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UBA7 Gene

protein-coding   GIFtS: 63
GCID: GC03M049848

Ubiquitin-Like Modifier Activating Enzyme 7

(Previous name: ubiquitin-activating enzyme E1-like)
(Previous symbol: UBE1L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Like Modifier Activating Enzyme 71 2     Ubiquitin-Activating Enzyme E1 Homolog B (Yeast)1
UBE1L1 2 3 5     Ubiquitin-Activating Enzyme E1-Like1
Ubiquitin-Activating Enzyme 72 3     UBA1B2
Ubiquitin-Activating Enzyme E1 Homolog2 3     UBA1, Ubiquitin-Activating Enzyme E1 Homolog B2
D82 3     UBA7, Ubiquitin-Activating Enzyme E12
UBE22 3     Ubiquitin-Activating Enzyme E1-Related Protein2
UBA11     Ubiquitin-Activating Enzyme-22
UBA71     Ubiquitin-Like Modifier-Activating Enzyme 72
Ubiquitin-Activating Enzyme E11     UBE75

External Ids:    HGNC: 124711   Entrez Gene: 73182   Ensembl: ENSG000001821797   OMIM: 1913255   UniProtKB: P412263   

Export aliases for UBA7 gene to outside databases

Previous GC identifers: GC03M049818 GC03M049844


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBA7 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid
target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and
apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like
interferon-stimulated gene 15 protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBA7 Gene:
UBA7 (ubiquitin-like modifier activating enzyme 7) is a protein-coding gene. Diseases associated with UBA7 include acute promyelocytic leukemia, and progeria. GO annotations related to this gene include ISG15 activating enzyme activity and ligase activity. An important paralog of this gene is UBA1.

UniProtKB/Swiss-Prot: UBA7_HUMAN, P41226
Function: Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking
this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.
Catalyzes the ISGylation of influenza A virus NS1 protein

Gene Wiki entry for UBA7 (UBE1L) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBA7 gene promoter:
         GR   NF-1/L   NF-1   AML1a   Pax-5   GR-beta   MyoD   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBA7 promoter sequence
   Search Chromatin IP Primers for UBA7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

UBA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBA7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049848:  view genomic region     (about GC identifiers)

Start:
49,842,638 bp from pter      End:
49,851,391 bp from pter
Size:
8,754 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBA7_HUMAN, P41226 (See protein sequence)
Recommended Name: Ubiquitin-like modifier-activating enzyme 7  
Size: 1012 amino acids; 111694 Da
Subunit: Monomer (By similarity). Binds and is involved in the conjugation of G1P2/ISG15
Miscellaneous: There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin
moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to
the thiol site
Secondary accessions: Q9BRB2

Explore the universe of human proteins at neXtProt for UBA7: NX_P41226

Explore proteomics data for UBA7 at MOPED

Post-translational modifications: 

  • ISGylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UBA7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003326.2  
    ENSEMBL proteins: 
     ENSP00000333266  
    Reactome Protein details: P41226

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE1: Ubiquitin-like modifier activating enzymes

    Selected InterPro protein domains (see all 10):
     IPR018074 UBQ-activ_enz_E1_AS
     IPR018965 Ub-activating_enz_e1_C
     IPR009036 Molybdenum_cofac_synth_MoeB
     IPR000594 ThiF_NAD_FAD-bd
     IPR018075 UBQ-activ_enz_E1

    Graphical View of Domain Structure for InterPro Entry P41226

    ProtoNet protein and cluster: P41226

    2 Blocks protein domains:
    IPB000011 Ubiquitin-activating enzyme
    IPB000594 UBA/THIF-type NAD/FAD binding fold


    UniProtKB/Swiss-Prot: UBA7_HUMAN, P41226
    Similarity: Belongs to the ubiquitin-activating E1 family


    UBA7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBA7_HUMAN, P41226
    Function: Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking
    this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.
    Catalyzes the ISGylation of influenza A virus NS1 protein

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005524ATP binding IEA--
    GO:0008641small protein activating enzyme activity ----
    GO:0016874ligase activity IEA--
    GO:0019782ISG15 activating enzyme activity IDA16428300
         
    UBA7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for UBA7:
     Decreased cilium length after   Increased cell death HMECs cel 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Uba7):
     cellular  normal 

    UBA7 for phenotypes           About GeneDecksing

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    UBA7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBA7 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    3RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    Negative regulators of RIG-I/MDA5 signaling0.42
    4CDK-mediated phosphorylation and removal of Cdc6
    Proteasome Degradation0.57
    5Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UBA7
        Parkinsons Disease Pathway
    Proteasome Degradation

    4 Reactome Pathways for UBA7
        Antigen processing: Ubiquitination & Proteasome degradation
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Negative regulators of RIG-I/MDA5 signaling
    ISG15 antiviral mechanism


    2 Kegg Pathways  (Kegg details for UBA7):
        Ubiquitin mediated proteolysis
    Parkinson's disease

    UniProtKB/Swiss-Prot: UBA7_HUMAN, P41226
    Pathway: Protein modification; protein ubiquitination


    UBA7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBA7
    Interactions:

        GeneGlobe Interaction Network for UBA7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBA7 (P412262, 3 ENSP000003332664) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ISG15P051612, 3, ENSP000003686994MINT-68321 I2D: score=6 STRING: ENSP00000368699
    FASP254453, ENSP000003479794I2D: score=2 STRING: ENSP00000347979
    DDX58ENSP000003692134STRING: ENSP00000369213
    HERC5ENSP000002643504STRING: ENSP00000264350
    RNF135ENSP000003283404STRING: ENSP00000328340
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process IDA16428300
    GO:0016567protein ubiquitination IEA--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0019941modification-dependent protein catabolic process IEA--
    GO:0032020ISG15-protein conjugation IDA16428300

    UBA7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for UBA7

    4 HMDB Compounds for UBA7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    3 Novoseek inferred chemical compound relationships for UBA7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoid 68.6 9 11891284 (4), 14976209 (2), 17302201 (1), 15520223 (1)
    retinoic acid 54.1 11 11891284 (4), 14976209 (4), 15520223 (1)
    cysteine 8.4 1 16407192 (1)



    UBA7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UBA7 gene: 
    NM_003335.2  

    Unigene Cluster for UBA7:

    Ubiquitin-like modifier activating enzyme 7
    Hs.16695  [show with all ESTs]
    Unigene Representative Sequence: NM_003335
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333486(uc003cxr.3) ENST00000497908 ENST00000488536 ENST00000483751
    ENST00000478875 ENST00000473992 ENST00000489826 ENST00000460516 ENST00000460703
    ENST00000478688 ENST00000494212
    miRNA
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    hsa-miR-1909*
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    Additional mRNA sequence: 

    BC006378.2 BT007026.1 L13852.1 

    11 DOTS entries:

    DT.445469  DT.92430180  DT.95243263  DT.40108845  DT.95113689  DT.100787258  DT.100787255  DT.95113692 
    DT.40194929  DT.97844492  DT.97864605 

    Selected AceView cDNA sequences (see all 213):

    AW576378 BF765765 BX482902 BM272748 CA314101 CA426107 BX096571 BM695256 
    CA866761 BF935874 CF453713 BU787668 AL547566 CK430594 BX346418 AL044030 
    CA866495 CA422452 AA928665 BM704555 BQ073643 AL044026 BM671696 CD516564 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBA7 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^
    SP1:                                                                                      -                                         -                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                          -     -     -     -     -     -   
    SP4:                                                        -                                                                                                   
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19a · 19b · 19c · 19d ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:  -     -     -     -     -     -     -                                                   
    SP4:                                                                                          
    SP5:                                -                                                         


    ECgene alternative splicing isoforms for UBA7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGACTTTGT
    UBA7 Expression
    About this image


    UBA7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    UBA7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBA7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16695

    UniProtKB/Swiss-Prot: UBA7_HUMAN, P41226
    Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell
    lines

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBA7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBA7 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uba71 , 5 ubiquitin-like modifier activating enzyme 71, 5 80.89(n)1
    75.69(a)1
      9 (59.07 cM)5
    741531  NM_023738.41  NP_076227.11 
     1079755055 
    chicken
    (Gallus gallus)
    Aves UBA76
    ubiquitin-like modifier activating enzyme 7
    46(a)
    1 ↔ 1
    12(2427451-2434824)
    lizard
    (Anolis carolinensis)
    Reptilia UBA76
    ubiquitin-like modifier activating enzyme 7
    46(a)
    1 ↔ 1
    2(147030628-147101885)
    zebrafish
    (Danio rerio)
    Actinopterygii uba76
    ubiquitin-like modifier activating enzyme 7
    43(a)
    many ↔ many
    6(52899852-52991541) ENSDARG00000061222
    fruit fly
    (Drosophila melanogaster)
    Insecta Uba16
    Ubiquitin activating enzyme 1
    34(a)
    1 → many
    2R(5575794-5580833)
    worm
    (Caenorhabditis elegans)
    Secernentea uba-16
    Protein UBA-1, isoform c
    33(a)
    1 → many
    IV(9989670-9995034) WBGene00006699
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBA16
    Ubiquitin activating enzyme (E1), involved in ubiq...
    37(a)
    1 → many
    XI(39163-42237) YKL210W


    ENSEMBL Gene Tree for UBA7 (if available)
    TreeFam Gene Tree for UBA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBA7 gene
    UBA12  UBA62  
    2 SIMAP similar genes for UBA7 using alignment to 1 protein entry:     UBA7_HUMAN:
    UBA1    UBA6

    UBA7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBA7 (see all 252)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1495714481,2
    --49842969(+) CAGGAA/GCCCAA 1 -- int10--------
    rs1923194461,2
    C--49843636(+) CTTACC/TTCCCC 1 -- int10--------
    rs2015940511,2
    C--49843647(+) CCAACC/GCCCAT 1 -- int10--------
    rs2020392841,2
    --49845792(+) GCCCCA/GCTCCT 1 -- int10--------
    rs22343861,2
    C,H--49845842(-) CTCCCC/GTGAAG 2 L V mis1 ese35Minor allele frequency- G:0.00NS EA NA 418
    rs2015452111,2
    C--49845916(+) GAGGGA/GATGTT 1 -- int10--------
    rs1477712731,2
    --49846004(+) CTTACC/TATTCC 1 -- int10--------
    rs22343851,2
    C,F--49846041(-) TGTAGC/TATTAA 1 -- int18Minor allele frequency- T:0.28WA NA CSA EA 368
    rs1816371261,2
    --49846292(+) GAGAGA/GTAGCA 1 -- int10--------
    rs1432603281,2
    C,F--49846412(+) ACCAAA/CCTCAG 2 V F mis11Minor allele frequency- C:0.00EU 1069

    HapMap Linkage Disequilibrium report for UBA7 (49842638 - 49851391 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for UBA7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876766CNV Loss21882294
    nsv834688CNV Loss17160897

    Human Gene Mutation Database (HGMD): UBA7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBA7
    DNA2.0 Custom Variant and Variant Library Synthesis for UBA7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191325    OMIM disorders: --

    12 diseases for UBA7:    
    About MalaCards
    acute promyelocytic leukemia    progeria    crohn's disease    leukemia
    hepatitis c virus    parkinson's disease    influenza    lung cancer
    hepatitis c    ulcerative colitis    myeloma    hepatitis


    UBA7 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for UBA7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia promyelocytic acute 65.9 2 11891284 (1), 14976209 (1)
    cancer lung 33.2 10 19074853 (3), 15520223 (3), 10709110 (2)
    cancer 9.96 3 10709110 (1), 14976209 (1)
    tumors 0 4 19074853 (1), 15520223 (1), 10709110 (1)

    Genetic Association Database (GAD): UBA7
    Human Genome Epidemiology (HuGE) Navigator: UBA7 (2 documents)

    Export disorders for UBA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBA7 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with UBA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. (PubMed id 8327486)1, 2, 3 Kok K.... Carritt B. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. Covalent protein modification with ISG15 via a conserved cysteine in the hinge region. (PubMed id 22693631)1, 2 Bade V.N....Praefcke G.J. (PLoS ONE 2012)
    3. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PubMed id 20601676)1, 4 Fransen K....Weersma R.K. (Hum. Mol. Genet. 2010)
    4. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PubMed id 20307617)1, 4 Morgan A.R....Ferguson L.R. (Hum. Immunol. 2010)
    5. Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. (PubMed id 16254333)1, 2 Lenschow D.J.... Virgin H.W. IV (J. Virol. 2005)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. (PubMed id 11157743)1, 2 Yuan W. and Krug R.M. (EMBO J. 2001)
    8. The genomic structure of the human UBE1L gene. (PubMed id 7734949)1, 2 Kok K....Buys C.H.C.M. (Gene Expr. 1995)
    9. UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. (PubMed id 11891284)1, 9 Kitareewan S....Dmitrovsky E. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. (PubMed id 14976209)1, 9 Pitha-Rowe I....Dmitrovsky E. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7318 HGNC: 12471 AceView: UBE1L Ensembl:ENSG00000182179 euGenes: HUgn7318
    ECgene: UBA7 Kegg: 7318 H-InvDB: UBA7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UBA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UBA7 gene:
    Search GeneIP for patents involving UBA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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