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Aliases for UBA7 Gene

Aliases for UBA7 Gene

  • Ubiquitin-Like Modifier Activating Enzyme 7 2 3
  • UBE1L 3 4 6
  • Ubiquitin-Activating Enzyme E1 Homolog 3 4
  • Ubiquitin-Activating Enzyme 7 3 4
  • UBE2 3 4
  • D8 3 4
  • Ubiquitin-Activating Enzyme E1 Homolog B (Yeast) 2
  • UBA1, Ubiquitin-Activating Enzyme E1 Homolog B 3
  • Ubiquitin-Activating Enzyme E1-Related Protein 3
  • Ubiquitin-Like Modifier-Activating Enzyme 7 3
  • UBA7, Ubiquitin-Activating Enzyme E1 3
  • Ubiquitin-Activating Enzyme E1-Like 2
  • Ubiquitin-Activating Enzyme E1 2
  • Ubiquitin-Activating Enzyme-2 3
  • UBA1B 3
  • UBA1 2
  • UBA7 2
  • UBE7 6

External Ids for UBA7 Gene

Previous HGNC Symbols for UBA7 Gene

  • UBE1L

Previous GeneCards Identifiers for UBA7 Gene

  • GC03M049818
  • GC03M049844
  • GC03M049848

Summaries for UBA7 Gene

Entrez Gene Summary for UBA7 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBA7 Gene

UBA7 (Ubiquitin-Like Modifier Activating Enzyme 7) is a Protein Coding gene. Diseases associated with UBA7 include hutchinson-gilford progeria and progeria. Among its related pathways are Class I MHC mediated antigen processing and presentation and Interferon Signaling. GO annotations related to this gene include ligase activity and ISG15 activating enzyme activity. An important paralog of this gene is UBA6.

UniProtKB/Swiss-Prot for UBA7 Gene

  • Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.

Gene Wiki entry for UBA7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBA7 Gene

Genomics for UBA7 Gene

Regulatory Elements for UBA7 Gene

Genomic Location for UBA7 Gene

Start:
49,805,205 bp from pter
End:
49,813,958 bp from pter
Size:
8,754 bases
Orientation:
Minus strand

Genomic View for UBA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBA7 Gene

Proteins for UBA7 Gene

  • Protein details for UBA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41226-UBA7_HUMAN
    Recommended name:
    Ubiquitin-like modifier-activating enzyme 7
    Protein Accession:
    P41226
    Secondary Accessions:
    • Q9BRB2

    Protein attributes for UBA7 Gene

    Size:
    1012 amino acids
    Molecular mass:
    111694 Da
    Quaternary structure:
    • Monomer (By similarity). Binds and is involved in the conjugation of G1P2/ISG15.
    Miscellaneous:
    • There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site

neXtProt entry for UBA7 Gene

Proteomics data for UBA7 Gene at MOPED

Post-translational modifications for UBA7 Gene

Other Protein References for UBA7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UBA7 Gene

Domains for UBA7 Gene

Gene Families for UBA7 Gene

HGNC:
  • UBE1 :Ubiquitin-like modifier activating enzymes

Suggested Antigen Peptide Sequences for UBA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41226

UniProtKB/Swiss-Prot:

UBA7_HUMAN :
  • P41226
Family:
  • Belongs to the ubiquitin-activating E1 family.
genes like me logo Genes that share domains with UBA7: view

Function for UBA7 Gene

Molecular function for UBA7 Gene

UniProtKB/Swiss-Prot Function: Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.

Gene Ontology (GO) - Molecular Function for UBA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004839 ubiquitin activating enzyme activity IBA --
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with UBA7: view

Phenotypes for UBA7 Gene

genes like me logo Genes that share phenotypes with UBA7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UBA7 Gene

Localization for UBA7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBA7 Gene COMPARTMENTS Subcellular localization image for UBA7 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBA7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBA7 Gene

Pathways for UBA7 Gene

genes like me logo Genes that share pathways with UBA7: view

UniProtKB/Swiss-Prot P41226-UBA7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006464 cellular protein modification process IDA 16428300
GO:0016567 protein ubiquitination IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0019941 modification-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with UBA7: view

Compounds for UBA7 Gene

(4) HMDB Compounds for UBA7 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(3) Novoseek inferred chemical compound relationships for UBA7 Gene

Compound -log(P) Hits PubMed IDs
retinoid 68.6 8
retinoic acid 54.1 9
cysteine 8.4 1
genes like me logo Genes that share compounds with UBA7: view

Transcripts for UBA7 Gene

Unigene Clusters for UBA7 Gene

Ubiquitin-like modifier activating enzyme 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBA7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^
SP1: - -
SP2:
SP3: - - - - - -
SP4: -
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: -

ExUns: 18 ^ 19a · 19b · 19c · 19d ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
SP1:
SP2:
SP3: - - - - - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:

Relevant External Links for UBA7 Gene

GeneLoc Exon Structure for
UBA7
ECgene alternative splicing isoforms for
UBA7

Expression for UBA7 Gene

mRNA expression in normal human tissues for UBA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBA7 Gene

SOURCE GeneReport for Unigene cluster for UBA7 Gene Hs.16695

mRNA Expression by UniProt/SwissProt for UBA7 Gene

P41226-UBA7_HUMAN
Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines
genes like me logo Genes that share expressions with UBA7: view

No data available for mRNA differential expression in normal tissues for UBA7 Gene

Orthologs for UBA7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBA7 35
  • 99.56 (n)
  • 99.19 (a)
UBA7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBA7 35
  • 82.7 (n)
  • 77.96 (a)
UBA7 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBA7 35
  • 84.06 (n)
  • 81.25 (a)
UBA7 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uba7 35
  • 80.89 (n)
  • 75.69 (a)
Uba7 16
Uba7 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBA7 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBA7 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uba7 35
  • 79.11 (n)
  • 74.84 (a)
chicken
(Gallus gallus)
Aves UBA7 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBA7 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uba7 36
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Uba1 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uba-1 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBA1 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for UBA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UBA7 Gene

ENSEMBL:
Gene Tree for UBA7 (if available)
TreeFam:
Gene Tree for UBA7 (if available)

Paralogs for UBA7 Gene

Paralogs for UBA7 Gene

Selected SIMAP similar genes for UBA7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBA7: view

Variants for UBA7 Gene

Sequence variations from dbSNP and Humsavar for UBA7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1799843 -- 49,812,290(-) AAGGT(C/G/T)TGGGA intron-variant
rs1799844 -- 49,810,209(-) TCCCA(C/T)TTCTG intron-variant
rs1799845 -- 49,810,190(-) CTCCC(C/T)TGCCA intron-variant
rs2234377 -- 49,813,571(-) TGGGG(A/G)CCGAG missense, reference
rs2234379 -- 49,811,887(-) GGCCA(C/G)CCCAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UBA7 Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV Loss 17160897
nsv876766 CNV Loss 21882294

Relevant External Links for UBA7 Gene

HapMap Linkage Disequilibrium report
UBA7
Human Gene Mutation Database (HGMD)
UBA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBA7 Gene

Disorders for UBA7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for UBA7 Gene including...

Search for UBA7 Gene in MalaCards »

(4) Novoseek inferred disease relationships for UBA7 Gene

Disease -log(P) Hits PubMed IDs
leukemia promyelocytic acute 65.9 2
cancer lung 33.2 8
cancer 9.96 2
tumors 0 3

Relevant External Links for UBA7

Genetic Association Database (GAD)
UBA7
Human Genome Epidemiology (HuGE) Navigator
UBA7
genes like me logo Genes that share disorders with UBA7: view

No data available for UniProtKB/Swiss-Prot for UBA7 Gene

Publications for UBA7 Gene

  1. A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. (PMID: 8327486) Kok K. … Carritt B. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4
  2. Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. (PMID: 11157743) Yuan W. … Krug R.M. (EMBO J. 2001) 3 4
  3. UBE1L causes lung cancer growth suppression by targeting cyclin D1. (PMID: 19074853) Feng Q. … Dmitrovsky E. (Mol. Cancer Ther. 2008) 3 23
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. (PMID: 16254333) Lenschow D.J. … Virgin H.W. IV (J. Virol. 2005) 3 4

Products for UBA7 Gene

  • Addgene plasmids for UBA7

Sources for UBA7 Gene

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