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Aliases for UBA7 Gene

Aliases for UBA7 Gene

  • Ubiquitin Like Modifier Activating Enzyme 7 2 3 5
  • Ubiquitin-Activating Enzyme E1 Homolog 3 4
  • UBA7, Ubiquitin-Activating Enzyme E1 2 3
  • Ubiquitin-Activating Enzyme 7 3 4
  • UBE1L 3 4
  • UBE2 3 4
  • D8 3 4
  • UBA1, Ubiquitin-Activating Enzyme E1 Homolog B (Yeast) 2
  • UBA1, Ubiquitin-Activating Enzyme E1 Homolog B 3
  • Ubiquitin-Activating Enzyme E1-Related Protein 3
  • Ubiquitin-Like Modifier Activating Enzyme 7 2
  • Ubiquitin-Like Modifier-Activating Enzyme 7 3
  • Ubiquitin-Activating Enzyme E1-Like 2
  • Ubiquitin-Activating Enzyme-2 3
  • UBA1B 3

External Ids for UBA7 Gene

Previous HGNC Symbols for UBA7 Gene

  • UBE1L

Previous GeneCards Identifiers for UBA7 Gene

  • GC03M049818
  • GC03M049844
  • GC03M049848

Summaries for UBA7 Gene

Entrez Gene Summary for UBA7 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBA7 Gene

UBA7 (Ubiquitin Like Modifier Activating Enzyme 7) is a Protein Coding gene. Diseases associated with UBA7 include Leukemia, Acute Promyelocytic, Somatic. Among its related pathways are Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template and Interferon gamma signaling. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin activating enzyme activity. An important paralog of this gene is UBA1.

UniProtKB/Swiss-Prot for UBA7 Gene

  • Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.

Gene Wiki entry for UBA7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBA7 Gene

Genomics for UBA7 Gene

Regulatory Elements for UBA7 Gene

Enhancers for UBA7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G049843 0.9 ENCODE 22.2 -31.2 -31240 2.5 ELF3 FOXA2 MLX ARID4B DMAP1 BMI1 RARA THAP11 ZHX2 MXD4 UBA7 GC03M049859 GC03M049858
GH03G049670 1.2 Ensembl ENCODE 8.6 +142.4 142438 1.8 HDGF FOXA2 ZFP64 ARID4B DMAP1 YY1 ZNF143 SP5 REST MIER3 AMT BSN-AS1 BSN BSN-AS2 CDHR4 UBA7 MST1 APEH PIR32155
GH03G049338 1.9 FANTOM5 ENCODE dbSUPER 2.4 +467.9 467909 14.7 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC AMT QRICH1 IMPDH2 DALRD3 RHOA WDR6 NICN1 USP4 ENSG00000230454 RHOA-IT1
GH03G050146 0.7 dbSUPER 4.2 -333.4 -333433 2.5 CTCF ESRRA PKNOX1 ZMYM3 RAD21 ZKSCAN1 GATA3 CTBP1 SMC3 PRDM10 RBM6 TMEM115 RHOA-IT1 SEMA3F-AS1 CYB561D2 UBA7 SEMA3F RBM5-AS1
GH03G049320 1.2 FANTOM5 2.4 +492.8 492804 0.6 HDGF MLX ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 SLC30A9 ZNF143 WDR6 C3orf62 NICN1 AMT LAMB2 KLHDC8B CCDC71 QARS USP4 IP6K1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBA7 on UCSC Golden Path with GeneCards custom track

Promoters for UBA7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152272 58 601 ELF3 FOXA2 ARID4B RAD21 ZBTB40 ZNF766 RELB IKZF2 HCFC1 REST

Genomic Location for UBA7 Gene

Chromosome:
3
Start:
49,805,205 bp from pter
End:
49,813,958 bp from pter
Size:
8,754 bases
Orientation:
Minus strand

Genomic View for UBA7 Gene

Genes around UBA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBA7 Gene

Proteins for UBA7 Gene

  • Protein details for UBA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41226-UBA7_HUMAN
    Recommended name:
    Ubiquitin-like modifier-activating enzyme 7
    Protein Accession:
    P41226
    Secondary Accessions:
    • Q9BRB2

    Protein attributes for UBA7 Gene

    Size:
    1012 amino acids
    Molecular mass:
    111694 Da
    Quaternary structure:
    • Monomer (By similarity). Binds and is involved in the conjugation of G1P2/ISG15.
    Miscellaneous:
    • There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.

neXtProt entry for UBA7 Gene

Post-translational modifications for UBA7 Gene

Other Protein References for UBA7 Gene

Antibody Products

  • R&D Systems Antibodies for UBA7 (ISG15 Activating Enzyme/UBE1L)
  • Cell Signaling Technology (CST) Antibodies for UBA7 (UBE1L)

No data available for DME Specific Peptides for UBA7 Gene

Domains & Families for UBA7 Gene

Gene Families for UBA7 Gene

Suggested Antigen Peptide Sequences for UBA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41226

UniProtKB/Swiss-Prot:

UBA7_HUMAN :
  • Belongs to the ubiquitin-activating E1 family.
Family:
  • Belongs to the ubiquitin-activating E1 family.
genes like me logo Genes that share domains with UBA7: view

Function for UBA7 Gene

Molecular function for UBA7 Gene

UniProtKB/Swiss-Prot Function:
Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.

Gene Ontology (GO) - Molecular Function for UBA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity EXP 18583345
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0008641 small protein activating enzyme activity IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with UBA7: view
genes like me logo Genes that share phenotypes with UBA7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBA7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UBA7 Gene

Localization for UBA7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBA7 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBA7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBA7 Gene

Pathways & Interactions for UBA7 Gene

genes like me logo Genes that share pathways with UBA7: view

UniProtKB/Swiss-Prot P41226-UBA7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IDA 16428300
GO:0016567 protein ubiquitination IEA --
GO:0019941 modification-dependent protein catabolic process IEA --
GO:0019985 translesion synthesis TAS --
GO:0032020 ISG15-protein conjugation IDA 16428300
genes like me logo Genes that share ontologies with UBA7: view

No data available for SIGNOR curated interactions for UBA7 Gene

Drugs & Compounds for UBA7 Gene

(4) Drugs for UBA7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for UBA7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBA7: view

Transcripts for UBA7 Gene

Unigene Clusters for UBA7 Gene

Ubiquitin-like modifier activating enzyme 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBA7

Alternative Splicing Database (ASD) splice patterns (SP) for UBA7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^
SP1: - -
SP2:
SP3: - - - - - -
SP4: -
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: -

ExUns: 18 ^ 19a · 19b · 19c · 19d ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
SP1:
SP2:
SP3: - - - - - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:

Relevant External Links for UBA7 Gene

GeneLoc Exon Structure for
UBA7
ECgene alternative splicing isoforms for
UBA7

Expression for UBA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBA7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.8) and Platelet (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBA7 Gene



Protein tissue co-expression partners for UBA7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBA7 Gene:

UBA7

SOURCE GeneReport for Unigene cluster for UBA7 Gene:

Hs.16695

mRNA Expression by UniProt/SwissProt for UBA7 Gene:

P41226-UBA7_HUMAN
Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.

Evidence on tissue expression from TISSUES for UBA7 Gene

  • Blood(4.4)
  • Liver(4.2)
  • Eye(4.1)
  • Lung(2.5)
  • Bone marrow(2.1)
  • Lymph node(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with UBA7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBA7 Gene

Orthologs for UBA7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBA7 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia UBA7 34 35
  • 84.06 (n)
cow
(Bos Taurus)
Mammalia UBA7 34 35
  • 82.7 (n)
mouse
(Mus musculus)
Mammalia Uba7 34 16 35
  • 80.89 (n)
rat
(Rattus norvegicus)
Mammalia Uba7 34
  • 79.11 (n)
oppossum
(Monodelphis domestica)
Mammalia UBA7 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBA7 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBA7 35
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBA7 35
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uba7 35
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Uba1 35
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uba-1 35
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBA1 35
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
Species where no ortholog for UBA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UBA7 Gene

ENSEMBL:
Gene Tree for UBA7 (if available)
TreeFam:
Gene Tree for UBA7 (if available)

Paralogs for UBA7 Gene

Paralogs for UBA7 Gene

(2) SIMAP similar genes for UBA7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBA7: view

Variants for UBA7 Gene

Sequence variations from dbSNP and Humsavar for UBA7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000797550 -- 49,808,736(+) ACTTA(C/T)TTATT intron-variant
rs1000827279 -- 49,808,231(+) CTCCT(C/T)TTGAT intron-variant, upstream-variant-2KB
rs1000837316 -- 49,810,454(+) TGTTG(A/G)GTGGG intron-variant, reference, synonymous-codon
rs1001288377 -- 49,811,173(+) GGTTG(A/G)TGAAG intron-variant
rs1001459573 -- 49,811,718(+) GGATG(C/T)GTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBA7 Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV loss 17160897

Variation tolerance for UBA7 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBA7 Gene

Human Gene Mutation Database (HGMD)
UBA7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBA7 Gene

Disorders for UBA7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBA7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute promyelocytic, somatic
  • leukemia, acute promyelocytic
- elite association - COSMIC cancer census association via MalaCards
Search UBA7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBA7

Genetic Association Database (GAD)
UBA7
Human Genome Epidemiology (HuGE) Navigator
UBA7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBA7
genes like me logo Genes that share disorders with UBA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBA7 Gene

Publications for UBA7 Gene

  1. A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. (PMID: 8327486) Kok K. … Carritt B. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 64
  2. Covalent protein modification with ISG15 via a conserved cysteine in the hinge region. (PMID: 22693631) Bade V.N. … Praefcke G.J. (PLoS ONE 2012) 3 4 64
  3. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan A.R. … Ferguson L.R. (Hum. Immunol. 2010) 3 46 64
  4. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PMID: 20601676) Fransen K. … Weersma R.K. (Hum. Mol. Genet. 2010) 3 46 64
  5. ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus. (PMID: 19073728) Giannakopoulos N.V. … Virgin H.W. (J. Virol. 2009) 3 22 64

Products for UBA7 Gene

  • Addgene plasmids for UBA7

Sources for UBA7 Gene

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