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Aliases for UBA7 Gene

Aliases for UBA7 Gene

  • Ubiquitin Like Modifier Activating Enzyme 7 2 3 5
  • Ubiquitin-Activating Enzyme E1 Homolog 3 4
  • UBA7, Ubiquitin-Activating Enzyme E1 2 3
  • Ubiquitin-Activating Enzyme 7 3 4
  • UBE1L 3 4
  • UBE2 3 4
  • D8 3 4
  • UBA1, Ubiquitin-Activating Enzyme E1 Homolog B (Yeast) 2
  • UBA1, Ubiquitin-Activating Enzyme E1 Homolog B 3
  • Ubiquitin-Activating Enzyme E1-Related Protein 3
  • Ubiquitin-Like Modifier Activating Enzyme 7 2
  • Ubiquitin-Like Modifier-Activating Enzyme 7 3
  • Ubiquitin-Activating Enzyme E1-Like 2
  • Ubiquitin-Activating Enzyme-2 3
  • UBA1B 3

External Ids for UBA7 Gene

Previous HGNC Symbols for UBA7 Gene

  • UBE1L

Previous GeneCards Identifiers for UBA7 Gene

  • GC03M049818
  • GC03M049844
  • GC03M049848

Summaries for UBA7 Gene

Entrez Gene Summary for UBA7 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBA7 Gene

UBA7 (Ubiquitin Like Modifier Activating Enzyme 7) is a Protein Coding gene. Diseases associated with UBA7 include Leukemia, Acute Promyelocytic, Somatic. Among its related pathways are Interferon gamma signaling and Immune System. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin activating enzyme activity. An important paralog of this gene is UBA1.

UniProtKB/Swiss-Prot for UBA7 Gene

  • Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.

Gene Wiki entry for UBA7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBA7 Gene

Genomics for UBA7 Gene

Regulatory Elements for UBA7 Gene

Enhancers for UBA7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F049843 0.2 ENCODE 22.2 -31.2 -31240 2.5 ELF3 MLX ARID4B DMAP1 RARA THAP11 MXD4 MIER2 NR2F2 KAT8 UBA7 GC03M049858 GC03M049859
GH03F049670 1.1 Ensembl ENCODE 8.6 +142.4 142438 1.8 ELF3 ZFP64 ARID4B DMAP1 THRB ZSCAN9 RAD21 RARA RFX5 YY1 AMT BSN-AS1 BSN BSN-AS2 CDHR4 UBA7 MST1 APEH PIR32155
GH03F049338 0.7 FANTOM5 ENCODE 2.4 +467.9 467909 14.7 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 AMT QRICH1 BSN-AS1 IMPDH2 LOC105377080 DALRD3 RHOA C3orf84 PHF5EP WDR6
GH03F049320 0.5 FANTOM5 2.4 +492.8 492804 0.6 HDGF MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 GLIS2 WDR6 C3orf62 NICN1 AMT LAMB2 CCDC71 KLHDC8B MIR6890 QARS USP4
GH03F049387 0.8 FANTOM5 ENCODE 1.5 +426.1 426111 0.2 ZNF384 FOS ZNF18 USP4 ARIH2 UBA7 QRICH1 TCTA RHOA-IT1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UBA7 on UCSC Golden Path with GeneCards custom track

Promoters for UBA7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001847755 -42 801 ELF3 IRF2 TFAP4 SAP130 ASH2L ARID4B RAD21 ZBTB40 GATAD1 POLR2A
ENSR00001847754 658 201

Genomic Location for UBA7 Gene

Chromosome:
3
Start:
49,805,205 bp from pter
End:
49,813,958 bp from pter
Size:
8,754 bases
Orientation:
Minus strand

Genomic View for UBA7 Gene

Genes around UBA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBA7 Gene

Proteins for UBA7 Gene

  • Protein details for UBA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41226-UBA7_HUMAN
    Recommended name:
    Ubiquitin-like modifier-activating enzyme 7
    Protein Accession:
    P41226
    Secondary Accessions:
    • Q9BRB2

    Protein attributes for UBA7 Gene

    Size:
    1012 amino acids
    Molecular mass:
    111694 Da
    Quaternary structure:
    • Monomer (By similarity). Binds and is involved in the conjugation of G1P2/ISG15.
    • Monomer (By similarity). Binds and is involved in the conjugation of G1P2/ISG15.
    Miscellaneous:
    • There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.

neXtProt entry for UBA7 Gene

Post-translational modifications for UBA7 Gene

Other Protein References for UBA7 Gene

Antibody Products

  • R&D Systems Antibodies for UBA7 (ISG15 Activating Enzyme/UBE1L)
  • Cell Signaling Technology (CST) Antibodies for UBA7 (UBE1L)

No data available for DME Specific Peptides for UBA7 Gene

Domains & Families for UBA7 Gene

Gene Families for UBA7 Gene

Suggested Antigen Peptide Sequences for UBA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41226

UniProtKB/Swiss-Prot:

UBA7_HUMAN :
  • Belongs to the ubiquitin-activating E1 family.
Family:
  • Belongs to the ubiquitin-activating E1 family.
genes like me logo Genes that share domains with UBA7: view

Function for UBA7 Gene

Molecular function for UBA7 Gene

UniProtKB/Swiss-Prot Function:
Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.

Gene Ontology (GO) - Molecular Function for UBA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004839 ubiquitin activating enzyme activity IBA --
GO:0004842 ubiquitin-protein transferase activity EXP,IBA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0008641 small protein activating enzyme activity IEA --
genes like me logo Genes that share ontologies with UBA7: view
genes like me logo Genes that share phenotypes with UBA7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBA7

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UBA7 Gene

Localization for UBA7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBA7 Gene COMPARTMENTS Subcellular localization image for UBA7 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBA7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBA7 Gene

Pathways & Interactions for UBA7 Gene

genes like me logo Genes that share pathways with UBA7: view

UniProtKB/Swiss-Prot P41226-UBA7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IDA 16428300
GO:0016567 protein ubiquitination IEA --
GO:0019941 modification-dependent protein catabolic process IEA,IBA --
GO:0019985 translesion synthesis TAS --
GO:0032020 ISG15-protein conjugation IDA 16428300
genes like me logo Genes that share ontologies with UBA7: view

No data available for SIGNOR curated interactions for UBA7 Gene

Drugs & Compounds for UBA7 Gene

(4) Drugs for UBA7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for UBA7 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBA7: view

Transcripts for UBA7 Gene

Unigene Clusters for UBA7 Gene

Ubiquitin-like modifier activating enzyme 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBA7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBA7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^
SP1: - -
SP2:
SP3: - - - - - -
SP4: -
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: -

ExUns: 18 ^ 19a · 19b · 19c · 19d ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
SP1:
SP2:
SP3: - - - - - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:

Relevant External Links for UBA7 Gene

GeneLoc Exon Structure for
UBA7
ECgene alternative splicing isoforms for
UBA7

Expression for UBA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBA7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.8) and Platelet (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBA7 Gene



Protein tissue co-expression partners for UBA7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBA7 Gene:

UBA7

SOURCE GeneReport for Unigene cluster for UBA7 Gene:

Hs.16695

mRNA Expression by UniProt/SwissProt for UBA7 Gene:

P41226-UBA7_HUMAN
Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.
genes like me logo Genes that share expression patterns with UBA7: view

Primer Products

No data available for mRNA differential expression in normal tissues for UBA7 Gene

Orthologs for UBA7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBA7 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia UBA7 34 35
  • 84.06 (n)
cow
(Bos Taurus)
Mammalia UBA7 34 35
  • 82.7 (n)
mouse
(Mus musculus)
Mammalia Uba7 34 16 35
  • 80.89 (n)
rat
(Rattus norvegicus)
Mammalia Uba7 34
  • 79.11 (n)
oppossum
(Monodelphis domestica)
Mammalia UBA7 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBA7 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBA7 35
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBA7 35
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uba7 35
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Uba1 35
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uba-1 35
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBA1 35
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
Species where no ortholog for UBA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UBA7 Gene

ENSEMBL:
Gene Tree for UBA7 (if available)
TreeFam:
Gene Tree for UBA7 (if available)

Paralogs for UBA7 Gene

Paralogs for UBA7 Gene

(2) SIMAP similar genes for UBA7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBA7: view

Variants for UBA7 Gene

Sequence variations from dbSNP and Humsavar for UBA7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs111416468 -- 49,809,816(+) TTACT(A/G)TTGGT downstream-variant-500B, reference, stop-gained
rs111499427 -- 49,813,606(+) CCCTG(A/G)CTCCC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs111694892 -- 49,807,683(+) GCAGG(C/T)GCAGG intron-variant, upstream-variant-2KB
rs111900212 -- 49,813,942(+) TCTTC(-/CTGGCTCCT)CTGGA upstream-variant-2KB, utr-variant-5-prime
rs112280882 -- 49,810,875(+) CTGCA(C/T)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBA7 Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV loss 17160897

Variation tolerance for UBA7 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBA7 Gene

Human Gene Mutation Database (HGMD)
UBA7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBA7 Gene

Disorders for UBA7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBA7 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
leukemia, acute promyelocytic, somatic
  • leukemia, acute promyelocytic
- elite association - COSMIC cancer census association via MalaCards
Search UBA7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBA7

Genetic Association Database (GAD)
UBA7
Human Genome Epidemiology (HuGE) Navigator
UBA7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBA7
genes like me logo Genes that share disorders with UBA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBA7 Gene

Publications for UBA7 Gene

  1. A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. (PMID: 8327486) Kok K. … Carritt B. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 64
  2. Covalent protein modification with ISG15 via a conserved cysteine in the hinge region. (PMID: 22693631) Bade V.N. … Praefcke G.J. (PLoS ONE 2012) 3 4 64
  3. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PMID: 20601676) Fransen K. … Weersma R.K. (Hum. Mol. Genet. 2010) 3 46 64
  4. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan A.R. … Ferguson L.R. (Hum. Immunol. 2010) 3 46 64
  5. ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus. (PMID: 19073728) Giannakopoulos N.V. … Virgin H.W. (J. Virol. 2009) 3 22 64

Products for UBA7 Gene

Sources for UBA7 Gene

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