 |
 | Services
| |
 |
Aliases & Descriptions for UBA6
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ10808 1, 2 | | FLJ23367 2 | | MOP-4 2, 3 | | MOP4 3 | | UBE1L2 2, 3 |
| | | Descriptions |
|---|
| Monocyte protein 4 3 | | UBA6, ubiquitin-activating enzyme E1 2 | | Ubiquitin-activating enzyme 6 3 | | Ubiquitin-activating enzyme E1-like protein 2 3 | | ubiquitin-activating enzyme E1-like 2 1, 2 | | ubiquitin-like modifier activating enzyme 6 2 |
|
| | Search outside databases for aliases for UBA6 gene |
Summaries for UBA6(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for UBA6: Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM] UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertilityGene Wiki entry for UBA6 (UBE1L2) |
Genomic Location for UBA6
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q13.2 Ensembl cytogenetic band: 4q13.2 HGNC cytogenetic band: 4q13.2UBA6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M068167:
(about GC identifiers)
Start:
|
68,164,074 bp from pter |
End:
|
68,249,484 bp from pter |
Size:
|
85,411 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000004.10 NT_022778.15
| Proteins for UBA6
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1 (See
protein sequence)Recommended Name: Ubiquitin-like modifier-activating enzyme 6 Size: 1052 amino acids; 117970 Da
Secondary accessions: A6N8M7 B2RAV3 Q4W5K0 Q6UV21 Q86T78 Q86TC7 Q8N5T3 Q8N9E4 Q9H3T7 Q9NVC9Alternative splicing: 4 isoforms: A0AVT1-1 A0AVT1-2 A0AVT1-3 A0AVT1-4 (Named isoforms)REFSEQ proteins: NP_060697.4
ENSEMBL proteins: ENSP00000313454
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for UBA6: Assays for UBA6: | Protein
Domains/ Families for UBA6(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry A0AVT1
ProtoNet protein and cluster: A0AVT1 UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1Similarity: Belongs to the ubiquitin-activating E1 family | Gene Function for UBA6
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC031637
Applied Biosystems Silencer® siRNAs for UBA6
Sigma-Aldrich siRNA and siRNA Panels for UBA6  Sigma-Aldrich shRNA for UBA6  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018227                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018227                                  untagged cDNA clones in CMV expression vector (see all 3): BC031637 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018227
UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Uba6):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for UBA6
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1Pathway: Protein modification; protein ubiquitination 4 Interacting proteins for UBA6 (ENSP000003134543 A0AVT12) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006464 | protein modification process |
IEA | -- | | GO:0019941 | modification-dependent protein catabolic process |
IEA | -- | About this table
|
Drugs & Compounds for UBA6(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for UBA6
|
Transcripts for UBA6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC031637
Sigma-Aldrich siRNA and siRNA Panels for UBA6  Sigma-Aldrich shRNA for UBA6  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018227 REFSEQ mRNAs for UBA6 gene: NM_018227.5
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018227               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018227                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018227                                  untagged cDNA clones in CMV expression vector (see all 3): BC031637  Additional cDNA sequence: AB014773.1 AK001670.1 AK027020.1 AK094164.1 AK094969.1 AK126301.1 AK314371.1 AL832015.2 AL832458.2 AY359880.1 BC031637.1 BC126484.1 BC126486.1 CR624797.1 EF623993.1 11 DOTS entries: DT.453030 DT.101980949 DT.75115934 DT.102825429 DT.75163789 DT.121229681 DT.121229680 DT.437731 DT.97825329 DT.91800551 DT.95275774 24/195 AceView cDNA sequences (see all 195
):AW118016 H85477 AI039310 AA630292 AA912403 BX442060 BQ773806 AI640674 BM454564 AL699392 AA490969 AW769262 AI453257 BC031637 AI142670 H84655 AW451445 BU679680 AL699427 AA281575 AA476932 BQ217426 BM973988 AW190853 Unigene Cluster for UBA6: Ubiquitin-like modifier activating enzyme 6 Hs.719086 [show with all ESTs]Unigene Representative Sequence: NM_018227
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000322244
|
Expression for UBA6
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBA6 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBA6
1 / 2 15 probe-sets matching UBA6 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.719086 UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1Tissue specificity: Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis |
Orthologs for UBA6
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBA6 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for UBA6
ENSEMBL Gene Tree for UBA6 | Paralogs for UBA6(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for UBA6 gene
- UBA12 UBA72
|
SNPs/Variants for UBA6(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for UBA6 (up to first 250kb)
|
Disorders & Mutations for UBA6
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611361
|
Medical News for UBA6(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for UBA6 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for UBA6 gene (see all 15
):- UBE1L2, a novel E1 enzyme specific for ubiquitin. (PubMed id 17580310)1, 2, 3 Pelzer C....Groettrup M. (2007)
- Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. (PubMed id 17597759)3, 4 Jin J.... Harper J.W. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)3, 4 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Identification and characteristics of a novel E1 like gene nUBE1L in human testis. (PubMed id 15202508)3, 4 Zhu H.... Sha J.-H. (2004)
- Activating the ubiquitin family: UBA6 challenges the field. (PubMed id 18353650)3 Groettrup M....Hofmann K. (2008)
- E1-L2 activates both ubiquitin and FAT10. (PubMed id 17889673)3 Chiu Y.H....Chen Z.J. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)3 Colland F....Gauthier J.M. (2004)
|
Search for UBA6
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBA6
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBA6
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBA6(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for UBA6(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for UBA6:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for UBA6 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|