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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBA6 Gene

protein-coding   GIFtS: 58
GCID: GC04M068481

Ubiquitin-Like Modifier Activating Enzyme 6

(Previous name: ubiquitin-activating enzyme E1-like 2)
(Previous symbol: UBE1L2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Like Modifier Activating Enzyme 61 2     MOP-42 3
UBE1L21 2 3     UBA61
Ubiquitin-Activating Enzyme E1-Like 21 2     Ubiquitin-Activating Enzyme E11
Monocyte Protein 42 3     UBA6, Ubiquitin-Activating Enzyme E12
Ubiquitin-Activating Enzyme 62 3     Ubiquitin-Like Modifier-Activating Enzyme 62
Ubiquitin-Activating Enzyme E1-Like Protein 22 3     MOP43
E1-L22 3     

External Ids:    HGNC: 255811   Entrez Gene: 552362   Ensembl: ENSG000000331787   OMIM: 6113615   UniProtKB: A0AVT13   

Export aliases for UBA6 gene to outside databases

Previous GC identifers: GC04M068167 GC04M064394


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBA6 Gene:
Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling
networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin
protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like
proteins (Jin et al., 2007 (PubMed 17597759)).(supplied by OMIM, Mar 2008)

GeneCards Summary for UBA6 Gene: 
UBA6 (ubiquitin-like modifier activating enzyme 6) is a protein-coding gene. Diseases associated with UBA6 include leber congenital amaurosis, and blindness, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include FAT10 activating enzyme activity and ligase activity. An important paralog of this gene is UBA1.

UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1
Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking
this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.
Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for
substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development.
Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence
spermatogenesis and male fertility

Gene Wiki entry for UBA6 (UBE1L2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBA6 gene promoter:
         Elk-1   AML1a   HTF   CUTL1   Nkx2-5   Zic1   NF-kappaB2   NF-kappaB1   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.2   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13.2

UBA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBA6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M068481:  view genomic region     (about GC identifiers)

Start:
68,481,479 bp from pter      End:
68,566,897 bp from pter
Size:
85,419 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1 (See protein sequence)
Recommended Name: Ubiquitin-like modifier-activating enzyme 6  
Size: 1052 amino acids; 117970 Da
Subunit: Forms a thioester with UBD in cells stimulated with tumor necrosis factor-alpha (TNFa) and
interferon-gamma (IFNg)
Sequence caution: Sequence=BAA91824.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6N8M7 B2RAV3 Q4W5K0 Q6UV21 Q86T78 Q86TC7 Q8N5T3 Q8N9E4 Q9H3T7 Q9NVC9
Alternative splicing: 4 isoforms:  A0AVT1-1   A0AVT1-2   A0AVT1-3   A0AVT1-4   

Explore the universe of human proteins at neXtProt for UBA6: NX_A0AVT1

Explore proteomics data for UBA6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A0AVT1

  • UBA6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBA6 Protein Expression
    REFSEQ proteins: NP_060697.4  
    ENSEMBL proteins: 
     ENSP00000313454   ENSP00000425091   ENSP00000421984   ENSP00000399234  
    Reactome Protein details: A0AVT1
    Human Recombinant Protein Products for UBA6: 
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    Cloud-Clone Corp. Proteins for UBA6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    UBA6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE1: Ubiquitin-like modifier activating enzymes

    5/9 InterPro protein domains (see all 9):
     IPR018075 UBQ-activ_enz_E1
     IPR018965 Ub-activating_enz_e1_C
     IPR000127 UBact_repeat
     IPR023280 Ub-like_act_enz_cat_cys_dom
     IPR019572 Ubiquitin-activating_enzyme

    Graphical View of Domain Structure for InterPro Entry A0AVT1

    ProtoNet protein and cluster: A0AVT1

    UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1
    Similarity: Belongs to the ubiquitin-activating E1 family


    UBA6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBA6_HUMAN, A0AVT1
    Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking
    this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.
    Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for
    substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development.
    Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence
    spermatogenesis and male fertility

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005515protein binding IPI17889673
    GO:0005524ATP binding IEA--
    GO:0008641small protein activating enzyme activity ----
    GO:0016874ligase activity IEA--
         
    UBA6 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBA6:
     Increased cell death in HCT116  Synthetic lethal with Ras  Synthetic lethal with imatinib 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Uba6):
     mortality/aging  no phenotypic analysis  normal 

    UBA6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Uba6tm1Zjc for UBA6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBA6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBA6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBA6 
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    miRNA
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    hsa-miR-549 hsa-miR-4254 hsa-miR-429 hsa-miR-200a hsa-miR-507 hsa-miR-519a hsa-miR-105 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidUBA6 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBA6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBA6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for UBA6
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBA6):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1
    Pathway: Protein modification; protein ubiquitination


    UBA6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for UBA6 (A0AVT12, 3 ENSP000003134544) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62132 I2D: score=3 
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    AIPL1ENSP000003705214STRING: ENSP00000370521
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0006511ubiquitin-dependent protein catabolic process IMP17889673
    GO:0016567protein ubiquitination IMP17889673

    UBA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBA6

    4 HMDB Compounds for UBA6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBA6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBA6 gene: 
    NM_018227.5  

    Unigene Cluster for UBA6:

    Ubiquitin-like modifier activating enzyme 6
    Hs.212774  [show with all ESTs]
    Unigene Representative Sequence: NM_018227
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322244(uc003hdg.4 uc003hdh.1) ENST00000514261 ENST00000505673
    ENST00000420827(uc003hdi.3) ENST00000429659(uc003hdj.2) ENST00000506571

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate UBA6 (see all 43):
    hsa-miR-549 hsa-miR-4254 hsa-miR-429 hsa-miR-200a hsa-miR-507 hsa-miR-519a hsa-miR-105 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidUBA6 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBA6

    Additional mRNA sequence: 

    AB014773.1 AK001670.1 AK027020.1 AK094164.1 AK094969.1 AK126301.1 AK314371.1 AL832015.2 
    AL832458.2 AY359880.1 BC031637.1 BC126484.1 BC126486.1 EF623993.1 

    11 DOTS entries:

    DT.453030  DT.101980949  DT.102825429  DT.75115934  DT.121229681  DT.75163789  DT.121229680  DT.437731 
    DT.91800551  DT.97825329  DT.95275774 

    24/195 AceView cDNA sequences (see all 195):

    H84655 AI453257 AL699427 BQ777561 AI142670 AI049513 AA912403 AA449298 
    AA978308 BM973988 BU679680 BC031637 AA490969 AA491162 AA630292 AI039310 
    AA281575 AB014773 AA035143 AL699392 AI640674 T10909 BM454600 AW204614 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATTGCTGT
    UBA6 Expression
    About this image


    See UBA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBA6

    SOURCE GeneReport for Unigene cluster: Hs.212774

    UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1
    Tissue specificity: Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in
    adult testis than in fetal testis

        SABiosciences Expression via Pathway-Focused PCR Array including UBA6: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBA6 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uba61 , 5 ubiquitin-like modifier activating enzyme 61, 5 88.24(n)1
    89.07(a)1
      5 (43.56 cM)5
    2313801  NM_172712.21  NP_766300.11 
     861107205 
    chicken
    (Gallus gallus)
    Aves UBA61 ubiquitin-like modifier activating enzyme 6 78.03(n)
    80.27(a)
      422655  XM_420609.3  XP_420609.3 
    lizard
    (Anolis carolinensis)
    Reptilia UBA66
    Uncharacterized protein
    80(a)
    1 ↔ 1
    6(58235061-58287181)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.138972 Xenopus laevis transcribed sequence with moderate similarity more 78.08(n)    CF289252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5673701 ubiquitin-like modifier-activating enzyme 6-like 65.11(n)
    66.6(a)
      567370  XM_690663.4  XP_695755.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Uba16
    Ubiquitin activating enzyme 1
    35(a)
    1 → many
    2R(5575794-5580833)
    worm
    (Caenorhabditis elegans)
    Secernentea uba-16
    Protein UBA-1, isoform a
    34(a)
    1 → many
    IV(9989670-9995034)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBA16
    Ubiquitin activating enzyme (E1), involved in ubiq...
    40(a)
    1 → many
    XI(39163-42237)


    ENSEMBL Gene Tree for UBA6 (if available)
    TreeFam Gene Tree for UBA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBA6 gene
    UBA12  UBA72  
    3 SIMAP similar genes for UBA6 using alignment to 4 protein entries:     UBA6_HUMAN (see all proteins):
    UBA2    UBA1    UBA7

    UBA6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1812 SNPs in UBA6 are shown (see all 1812)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342480001,2
    C--64446117(+) AAACA-/GATATAT 1 -- int11Minor allele frequency- GA:0.00NA 2
    rs341363371,2
    C--64475459(+) ATACA-/AC/TA 
            
    CACAC
    1 -- int10--------
    rs1131950831,2
    C--68447094(+) TGCAAT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1164965041,2
    C,F--68481239(+) ATGAAT/CACCCT 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1912900751,2
    --68481438(+) AACATG/TAATCA 1 -- ds50010--------
    rs726423471,2
    C--68481474(+) CAAAAC/GAATGT 1 -- ds50010--------
    rs1388831481,2
    C--68481608(+) GGGTAC/TGTGGC 1 -- ut310--------
    rs1834829091,2
    --68481620(+) GGGAGA/CTGGTT 1 -- ut310--------
    rs1429048381,2
    C--68481631(+) GTGACC/TGGGAA 1 -- ut310--------
    rs1445437361,2
    --68481746(+) TTTATA/GTATTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UBA6 (68481479 - 68566897 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UBA6:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv5579n71CNV Loss21882294
    nsv879215CNV Loss21882294
    nsv879214CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611361    OMIM disorders: --

    2 diseases for UBA6:    About MalaCards
    leber congenital amaurosis    blindness


    UBA6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UBA6

    Export disorders for UBA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBA6 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with UBA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. UBE1L2, a novel E1 enzyme specific for ubiquitin. (PubMed id 17580310)1, 3, 9 Pelzer C....Groettrup M. (2007)
    2. E1-L2 activates both ubiquitin and FAT10. (PubMed id 17889673)1, 2 Chiu Y.H....Chen Z.J. (2007)
    3. Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. (PubMed id 17597759)1, 2 Jin J.... Harper J.W. (2007)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Identification and characteristics of a novel E1 like gene nUBE1L in human testis. (PubMed id 15202508)1, 2 Zhu H.... Sha J.-H. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Mechanistic studies on activation of ubiquitin and di- ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, U ba6. (PubMed id 22427669)1 Gavin J.M....Dick L.R. (2012)
    10. Specificity of the E1-E2-E3 enzymatic cascade for ubiq uitin C-terminal sequences identified by phage display. (PubMed id 23003343)1 Zhao B....Yin J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55236 HGNC: 25581 AceView: FLJ10808 Ensembl:ENSG00000033178 euGenes: HUgn55236
    ECgene: UBA6 Kegg: 55236 H-InvDB: UBA6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBA6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBA6 gene:
    Search GeneIP for patents involving UBA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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