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Aliases for UBA6 Gene

Aliases for UBA6 Gene

  • Ubiquitin-Like Modifier Activating Enzyme 6 2 3
  • Ubiquitin-Activating Enzyme E1-Like Protein 2 3 4
  • Ubiquitin-Activating Enzyme E1-Like 2 2 3
  • Ubiquitin-Activating Enzyme 6 3 4
  • Monocyte Protein 4 3 4
  • UBE1L2 3 4
  • E1-L2 3 4
  • MOP-4 3 4
  • UBA6, Ubiquitin-Activating Enzyme E1 3
  • Ubiquitin-Activating Enzyme E1 2
  • MOP4 4
  • UBA6 2

External Ids for UBA6 Gene

Previous HGNC Symbols for UBA6 Gene

  • UBE1L2

Previous GeneCards Identifiers for UBA6 Gene

  • GC04M068167
  • GC04M068481
  • GC04M064394

Summaries for UBA6 Gene

Entrez Gene Summary for UBA6 Gene

  • Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UBA6 Gene

UBA6 (Ubiquitin-Like Modifier Activating Enzyme 6) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and FAT10 activating enzyme activity. An important paralog of this gene is UBA7.

UniProtKB/Swiss-Prot for UBA6 Gene

  • Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.

Gene Wiki entry for UBA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBA6 Gene

Genomics for UBA6 Gene

Regulatory Elements for UBA6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBA6 Gene

Chromosome:
4
Start:
67,612,652 bp from pter
End:
67,701,179 bp from pter
Size:
88,528 bases
Orientation:
Minus strand

Genomic View for UBA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for UBA6 Gene

Proteins for UBA6 Gene

  • Protein details for UBA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AVT1-UBA6_HUMAN
    Recommended name:
    Ubiquitin-like modifier-activating enzyme 6
    Protein Accession:
    A0AVT1
    Secondary Accessions:
    • A6N8M7
    • B2RAV3
    • Q4W5K0
    • Q6UV21
    • Q86T78
    • Q86TC7
    • Q8N5T3
    • Q8N9E4
    • Q9H3T7
    • Q9NVC9

    Protein attributes for UBA6 Gene

    Size:
    1052 amino acids
    Molecular mass:
    117970 Da
    Quaternary structure:
    • Forms a thioester with UBD in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg)
    SequenceCaution:
    • Sequence=BAA91824.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for UBA6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBA6 Gene

Proteomics data for UBA6 Gene at MOPED

Post-translational modifications for UBA6 Gene

  • Ubiquitination at Lys 544, Lys 644, Lys 652, Lys 687, Lys 729, Lys 739, Lys 830, and Lys 889
  • Modification sites at PhosphoSitePlus

Other Protein References for UBA6 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBA6 (UBE1L2)

No data available for DME Specific Peptides for UBA6 Gene

Domains & Families for UBA6 Gene

Gene Families for UBA6 Gene

Suggested Antigen Peptide Sequences for UBA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0AVT1

UniProtKB/Swiss-Prot:

UBA6_HUMAN :
  • Belongs to the ubiquitin-activating E1 family.
Family:
  • Belongs to the ubiquitin-activating E1 family.
genes like me logo Genes that share domains with UBA6: view

Function for UBA6 Gene

Molecular function for UBA6 Gene

UniProtKB/Swiss-Prot Function:
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.

Gene Ontology (GO) - Molecular Function for UBA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004839 ubiquitin activating enzyme activity IBA --
GO:0005515 protein binding IPI 17889673
GO:0005524 ATP binding IEA --
GO:0008641 small protein activating enzyme activity --
GO:0019780 FAT10 activating enzyme activity IMP 17889673
genes like me logo Genes that share ontologies with UBA6: view
genes like me logo Genes that share phenotypes with UBA6: view

Animal Models for UBA6 Gene

MGI Knock Outs for UBA6:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBA6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for UBA6 Gene

Localization for UBA6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBA6 Gene COMPARTMENTS Subcellular localization image for UBA6 gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for UBA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol --
genes like me logo Genes that share ontologies with UBA6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBA6 Gene

Pathways & Interactions for UBA6 Gene

genes like me logo Genes that share pathways with UBA6: view

Pathways by source for UBA6 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot A0AVT1-UBA6_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for UBA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process --
GO:0006511 ubiquitin-dependent protein catabolic process IMP 17889673
GO:0007612 learning IEA --
GO:0007626 locomotory behavior IEA --
GO:0016567 protein ubiquitination IMP 17889673
genes like me logo Genes that share ontologies with UBA6: view

No data available for SIGNOR curated interactions for UBA6 Gene

Drugs & Compounds for UBA6 Gene

(4) Drugs for UBA6 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
PYR 41 Pharma Ubiquitin-activating enzyme (E1) inhibitor 0

(3) Additional Compounds for UBA6 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
NSC 624206
13116-77-3
PYZD 4409
423148-78-1
genes like me logo Genes that share compounds with UBA6: view

Transcripts for UBA6 Gene

Unigene Clusters for UBA6 Gene

Ubiquitin-like modifier activating enzyme 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBA6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBA6 Gene

No ASD Table

Relevant External Links for UBA6 Gene

GeneLoc Exon Structure for
UBA6
ECgene alternative splicing isoforms for
UBA6

Expression for UBA6 Gene

mRNA expression in normal human tissues for UBA6 Gene

Protein differential expression in normal tissues from HIPED for UBA6 Gene

This gene is overexpressed in Lymph node (12.6) and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBA6 Gene



SOURCE GeneReport for Unigene cluster for UBA6 Gene Hs.212774

mRNA Expression by UniProt/SwissProt for UBA6 Gene

A0AVT1-UBA6_HUMAN
Tissue specificity: Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.
genes like me logo Genes that share expression patterns with UBA6: view

Protein tissue co-expression partners for UBA6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBA6 Gene

Orthologs for UBA6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBA6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBA6 35
  • 92.05 (n)
  • 91.92 (a)
UBA6 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBA6 35
  • 92.4 (n)
  • 92.02 (a)
UBA6 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uba6 35
  • 88.24 (n)
  • 89.07 (a)
Uba6 16
Uba6 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBA6 35
  • 99.65 (n)
  • 99.52 (a)
UBA6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uba6 35
  • 88.02 (n)
  • 89.35 (a)
oppossum
(Monodelphis domestica)
Mammalia UBA6 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBA6 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBA6 35
  • 78.09 (n)
  • 80.22 (a)
UBA6 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBA6 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uba6 35
  • 73.21 (n)
  • 74.58 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13897 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-82j4.2 35
  • 65.36 (n)
  • 66.86 (a)
UBA6 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Uba1 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uba-1 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBA1 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for UBA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBA6 Gene

ENSEMBL:
Gene Tree for UBA6 (if available)
TreeFam:
Gene Tree for UBA6 (if available)

Paralogs for UBA6 Gene

Paralogs for UBA6 Gene

(3) SIMAP similar genes for UBA6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UBA6: view

Variants for UBA6 Gene

Sequence variations from dbSNP and Humsavar for UBA6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_030594 -

Structural Variations from Database of Genomic Variants (DGV) for UBA6 Gene

Variant ID Type Subtype PubMed ID
nsv879214 CNV Gain 21882294
nsv879215 CNV Loss 21882294
dgv5579n71 CNV Loss 21882294

Variation tolerance for UBA6 Gene

Residual Variation Intolerance Score: 7.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.74; 83.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBA6 Gene

HapMap Linkage Disequilibrium report
UBA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBA6 Gene

Disorders for UBA6 Gene

Relevant External Links for UBA6

Genetic Association Database (GAD)
UBA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBA6
genes like me logo Genes that share disorders with UBA6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBA6 Gene

Publications for UBA6 Gene

  1. UBE1L2, a novel E1 enzyme specific for ubiquitin. (PMID: 17580310) Pelzer C. … Groettrup M. (J. Biol. Chem. 2007) 2 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for UBA6 Gene

Sources for UBA6 Gene

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