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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBA6 Gene

protein-coding   GIFtS: 54
GCID: GC04M068481

ubiquitin-like modifier activating enzyme 6

(Previous name: ubiquitin-activating enzyme E1-like 2 )
(Previous symbol: UBE1L2)
 Explore 2 diseases affiliated with
UBA6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UBA6    

Aliases
for UBA6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin-Like Modifier Activating Enzyme 61 2     E1-L22 3
UBE1L21 2 3     MOP-42 3
Ubiquitin-Activating Enzyme E1-Like 21 2     FLJ108081
Monocyte Protein 42 3     UBA6, Ubiquitin-Activating Enzyme E12
Ubiquitin-Activating Enzyme 62 3     Ubiquitin-Like Modifier-Activating Enzyme 62
Ubiquitin-Activating Enzyme E1-Like Protein 22 3     MOP43

External Ids:    HGNC: 255811   Entrez Gene: 552362   Ensembl: ENSG000000331787   OMIM: 6113615   UniProtKB: A0AVT13   

Export aliases for UBA6 gene to outside databases

Previous GC identifers: GC04M068167 GC04M064394


Summaries
for UBA6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UBA6:
Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks
and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase
(E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al.,
2007 (PubMed 17597759)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1
Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this
residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Specific for
ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging.
Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10
conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility

Gene Wiki entry for UBA6 (UBE1L2)


Genomic Views
for UBA6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBA6 gene promoter:
         Elk-1   AML1a   HTF   CUTL1   Nkx2-5   Zic1   NF-kappaB2   NF-kappaB1   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.2   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13.2

UBA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBA6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M068481:  view genomic region     (about GC identifiers)

Start:
 68,481,479 bp from pter      End:
 68,566,897 bp from pter
Size:
 85,419 bases      Orientation:
 minus strand

Proteins
for UBA6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1 (See protein sequence)
Recommended Name: Ubiquitin-like modifier-activating enzyme 6  
Size: 1052 amino acids; 117970 Da
Subunit: Forms a thioester with UBD in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma
(IFNg)
Sequence caution: Sequence=BAA91824.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6N8M7 B2RAV3 Q4W5K0 Q6UV21 Q86T78 Q86TC7 Q8N5T3 Q8N9E4 Q9H3T7 Q9NVC9
Alternative splicing: 4 isoforms:  A0AVT1-1   A0AVT1-2   A0AVT1-3   A0AVT1-4   

Explore the universe of human proteins at neXtProt for UBA6: NX_A0AVT1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A0AVT1

    • UBA6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060697.4  
    ENSEMBL proteins: 
     ENSP00000313454   ENSP00000425091   ENSP00000421984   ENSP00000399234  
    Reactome Protein details: A0AVT1
    Human Recombinant Protein Products: 
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    Novus Biologicals UBA6 Proteins
    Novus Biologicals UBA6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UBA6

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--


    UBA6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for UBA6

    Protein Domains /
    Families
    for UBA6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UBA6 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR018075 UBQ-activ_enz_E1
     IPR018965 Ub-activating_enz_e1_C
     IPR000127 UBact_repeat
     IPR023280 Ub-like_act_enz_cat_cys_dom
     IPR019572 Ubiquitin-activating_enzyme

    Graphical View of Domain Structure for InterPro Entry A0AVT1

    ProtoNet protein and cluster: A0AVT1

    UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1
    Similarity: Belongs to the ubiquitin-activating E1 family


    Function
    for UBA6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1
    Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this
    residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Specific for
    ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging.
    Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10
    conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate UBA6 (see all 43):
    hsa-miR-549 hsa-miR-4254 hsa-miR-429 hsa-miR-200a hsa-miR-507 hsa-miR-519a hsa-miR-105 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmid: UBA6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBA6 (see all 4)
    OriGene shRNA RFP: UBA6
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBA6

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for UBA6

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17889673
    GO:0005524ATP binding IEA--
    GO:0008641small protein activating enzyme activity ----
    GO:0016874ligase activity IEA--
    GO:0019780FAT10 activating enzyme activity IMP17889673


    UBA6 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for UBA6:
     Increased cell death in HCT116  Synthetic lethal with Ras  Synthetic lethal with imatinib 

    Animal Models:
         Mouse knock-out Uba6tm1Zjc for UBA6
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Uba6):
     mortality/aging 

    UBA6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UBA6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Ubiquitin mediated proteolysis0.36
    		Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for UBA6
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBA6):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1
    Pathway: Protein modification; protein ubiquitination


    UBA6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for UBA6 (A0AVT12, 3 ENSP000003134544) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62132 I2D: score=3 
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    AIPL1ENSP000003705214STRING: ENSP00000370521
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0006511ubiquitin-dependent protein catabolic process IMP17889673
    GO:0016567protein ubiquitination IMP17889673


    UBA6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UBA6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBA6

    4 HMDB Compounds for UBA6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about UBA6 

    Transcripts
    for UBA6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UBA6 gene: 
    NM_018227.5  

    Unigene Cluster for UBA6:

    Ubiquitin-like modifier activating enzyme 6
    Hs.212774  [show with all ESTs]
    Unigene Representative Sequence: NM_018227
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322244(uc003hdg.4 uc003hdh.1) ENST00000514261 ENST00000505673
    ENST00000420827(uc003hdi.3) ENST00000429659(uc003hdj.2) ENST00000506571


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBA6
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate UBA6 (see all 43):
    hsa-miR-549 hsa-miR-4254 hsa-miR-429 hsa-miR-200a hsa-miR-507 hsa-miR-519a hsa-miR-105 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmid: UBA6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBA6 (see all 4)
    OriGene shRNA RFP: UBA6
    OriGene siRNA: UBA6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBA6
    Clone
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    GenScript: all cDNA clones in your preferred vector: UBA6 (NM_018227)
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    Primer
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    Additional cDNA sequence: 

    AB014773.1 AK001670.1 AK027020.1 AK094164.1 AK094969.1 AK126301.1 AK314371.1 AL832015.2 
    AL832458.2 AY359880.1 BC031637.1 BC126484.1 BC126486.1 EF623993.1 

    11 DOTS entries:

    DT.453030  DT.101980949  DT.102825429  DT.75115934  DT.121229681  DT.75163789  DT.121229680  DT.437731 
    DT.91800551  DT.97825329  DT.95275774 

    24/195 AceView cDNA sequences (see all 195):

    BM454564 BX442060 AA978308 BU679680 AA035143 AB014773 AA281575 BM969179 
    AI584176 AW769262 AA476932 AW204614 AL699392 AA491162 AA490969 AI453257 
    BC031637 BM454600 T10909 AI342190 AW118016 H84655 AW190853 AW874515 

    GeneLoc Exon Structure


    Expression
    for UBA6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGATTGCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UBA6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)Bone, Cartilage, Limb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UBA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBA6

    SOURCE GeneReport for Unigene cluster: Hs.212774

    UniProtKB/Swiss-Prot: UBA6_HUMAN, A0AVT1
    Tissue specificity: Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult
    testis than in fetal testis

        SABiosciences Expression via Pathway-Focused PCR Array including UBA6: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBA6

    Orthologs
    for UBA6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for UBA6 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UBA61 ubiquitin-like modifier activating enzyme 6 78.03(n)
    80.27(a)    		   422655  XM_420609.3  XP_420609.3 
    lizard
    (Anolis carolinensis)    		 Reptilia UBA66
    		 --
    		 80(a)
    		 1 ↔ 1
    		 6(58237702-58287160)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.138972 Xenopus laevis transcribed sequence with moderate similarity more 78.08(n)    CF289252.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5673701 ubiquitin-like modifier-activating enzyme 6-like 65.11(n)
    66.6(a)    		   567370  XM_690663.4  XP_695755.3 


    ENSEMBL Gene Tree for UBA6 (if available)
    TreeFam Gene Tree for UBA6 (if available) 

    Paralogs
    for UBA6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBA6 gene
    UBA12  UBA72  
    3 SIMAP similar genes for UBA6 using alignment to 4 protein entries:     UBA6_HUMAN (see all proteins):
    UBA2    UBA1    UBA7

    UBA6 for paralogs           About GeneDecksing



    Genomic Variants
    for UBA6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBA6
    DNA2.0 Custom Variant and Variant Library Synthesis for UBA6

    Disorders / Diseases
    for UBA6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UBA6 for disorders           About GeneDecksing

    OMIM gene information: 611361    OMIM disorders: --

    2 diseases for UBA6:    About MalaCards
    leber congenital amaurosis    malaria


    Export disorders for UBA6 gene to outside databases

    Publications
    for UBA6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBA6 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with UBA6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. UBE1L2, a novel E1 enzyme specific for ubiquitin. (PubMed id 17580310)1, 3, 9 Pelzer C....Groettrup M. (2007)
    2. E1-L2 activates both ubiquitin and FAT10. (PubMed id 17889673)1, 2 Chiu Y.H....Chen Z.J. (2007)
    3. Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. (PubMed id 17597759)1, 2 Jin J.... Harper J.W. (2007)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Identification and characteristics of a novel E1 like gene nUBE1L in human testis. (PubMed id 15202508)1, 2 Zhu H.... Sha J.-H. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Mechanistic studies on activation of ubiquitin and di- ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, U ba6. (PubMed id 22427669)1 Gavin J.M....Dick L.R. (2012)
    10. Specificity of the E1-E2-E3 enzymatic cascade for ubiq uitin C-terminal sequences identified by phage display. (PubMed id 23003343)1 Zhao B....Yin J. (2012)

    External Searches for UBA6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing UBA6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55236 HGNC: 25581 AceView: FLJ10808 Ensembl:ENSG00000033178 euGenes: HUgn55236
    ECgene: UBA6 Kegg: 55236 H-InvDB: UBA6

    Other Databases showing UBA6 gene

    (According to HUGE)
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    Specialized Databases showing UBA6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBA6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UBA6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for UBA6 gene:
    Search GeneIP for patents involving UBA6

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