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Aliases for UBA6 Gene

Aliases for UBA6 Gene

  • Ubiquitin Like Modifier Activating Enzyme 6 2 3 5
  • Ubiquitin-Activating Enzyme E1-Like Protein 2 3 4
  • Ubiquitin-Activating Enzyme E1-Like 2 2 3
  • UBA6, Ubiquitin-Activating Enzyme E1 2 3
  • Ubiquitin-Activating Enzyme 6 3 4
  • Monocyte Protein 4 3 4
  • UBE1L2 3 4
  • E1-L2 3 4
  • MOP-4 3 4
  • Ubiquitin-Like Modifier Activating Enzyme 6 2
  • Ubiquitin-Like Modifier-Activating Enzyme 6 3
  • EC 6.2.1.45 4
  • MOP4 4

External Ids for UBA6 Gene

Previous HGNC Symbols for UBA6 Gene

  • UBE1L2

Previous GeneCards Identifiers for UBA6 Gene

  • GC04M068167
  • GC04M068481
  • GC04M064394

Summaries for UBA6 Gene

Entrez Gene Summary for UBA6 Gene

  • Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UBA6 Gene

UBA6 (Ubiquitin Like Modifier Activating Enzyme 6) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and FAT10 activating enzyme activity. An important paralog of this gene is UBA1.

UniProtKB/Swiss-Prot for UBA6 Gene

  • Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.

Gene Wiki entry for UBA6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBA6 Gene

Genomics for UBA6 Gene

Regulatory Elements for UBA6 Gene

Enhancers for UBA6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G067697 1.6 Ensembl ENCODE dbSUPER 35.7 +1.0 991 4.8 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YBX1 YY1 UBA6 UBA6-AS1 CENPC STAP1 TMPRSS11D GC04P067653
GH04G067720 1.6 Ensembl ENCODE dbSUPER 24.2 -20.5 -20455 2.4 PKNOX1 ARNT SIN3A YY1 ZNF766 FOS KLF13 REST ZNF592 KAT8 UBA6 UBA6-AS1 GNRHR LOC100419862 PIR51733
GH04G067712 1.4 Ensembl ENCODE dbSUPER 26.6 -12.9 -12893 2.2 HDAC1 PKNOX1 ATF1 THRB TCF12 GATA2 FOS CREM SMARCA5 ELF1 UBA6 UBA6-AS1 GNRHR STAP1 ST3GAL1P1 GC04M067708
GH04G067725 1.3 Ensembl ENCODE dbSUPER 26.9 -25.4 -25372 4.4 CTCF PKNOX1 CBX3 JUN NFXL1 RAD21 KAT2B YY1 FOSL1 ZNF316 UBA6 GNRHR TMPRSS11D LOC100419046 GC04P067742
GH04G067543 1.3 ENCODE dbSUPER 16 +156.0 156047 2.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 CENPC UBA6 LOC101927237 STAP1 GCOM2 GC04M067379
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBA6 on UCSC Golden Path with GeneCards custom track

Promoters for UBA6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000168889 79 2201 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YBX1

Genomic Location for UBA6 Gene

Chromosome:
4
Start:
67,612,652 bp from pter
End:
67,701,179 bp from pter
Size:
88,528 bases
Orientation:
Minus strand

Genomic View for UBA6 Gene

Genes around UBA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBA6 Gene

Proteins for UBA6 Gene

  • Protein details for UBA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AVT1-UBA6_HUMAN
    Recommended name:
    Ubiquitin-like modifier-activating enzyme 6
    Protein Accession:
    A0AVT1
    Secondary Accessions:
    • A6N8M7
    • B2RAV3
    • Q4W5K0
    • Q6UV21
    • Q86T78
    • Q86TC7
    • Q8N5T3
    • Q8N9E4
    • Q9H3T7
    • Q9NVC9

    Protein attributes for UBA6 Gene

    Size:
    1052 amino acids
    Molecular mass:
    117970 Da
    Quaternary structure:
    • Forms a thioester with UBD in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg).
    SequenceCaution:
    • Sequence=BAA91824.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for UBA6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBA6 Gene

Post-translational modifications for UBA6 Gene

  • Ubiquitination at posLast=544544, Lys644, posLast=652652, Lys687, posLast=729729, isoforms=2739, Lys830, and Lys889
  • Modification sites at PhosphoSitePlus

Other Protein References for UBA6 Gene

No data available for DME Specific Peptides for UBA6 Gene

Domains & Families for UBA6 Gene

Gene Families for UBA6 Gene

Suggested Antigen Peptide Sequences for UBA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0AVT1

UniProtKB/Swiss-Prot:

UBA6_HUMAN :
  • Belongs to the ubiquitin-activating E1 family.
Family:
  • Belongs to the ubiquitin-activating E1 family.
genes like me logo Genes that share domains with UBA6: view

Function for UBA6 Gene

Molecular function for UBA6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.

Enzyme Numbers (IUBMB) for UBA6 Gene

Gene Ontology (GO) - Molecular Function for UBA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004839 ubiquitin activating enzyme activity IEA --
GO:0005515 protein binding IPI 17889673
GO:0005524 ATP binding IEA --
GO:0008641 small protein activating enzyme activity IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with UBA6: view
genes like me logo Genes that share phenotypes with UBA6: view

Animal Models for UBA6 Gene

MGI Knock Outs for UBA6:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBA6

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBA6 Gene

Localization for UBA6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBA6 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBA6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBA6 Gene

Pathways & Interactions for UBA6 Gene

genes like me logo Genes that share pathways with UBA6: view

UniProtKB/Swiss-Prot A0AVT1-UBA6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IMP 17889673
GO:0007612 learning IEA --
GO:0007626 locomotory behavior IEA --
GO:0016567 protein ubiquitination TAS,IMP --
genes like me logo Genes that share ontologies with UBA6: view

No data available for SIGNOR curated interactions for UBA6 Gene

Drugs & Compounds for UBA6 Gene

(5) Drugs for UBA6 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
PYZD-4409 Pharma E1 enzyme inhibitor, Ubiquitin-activating enzyme (E1) inhibitor 0
PYR-41 Pharma Ubiquitin-activating enzyme (E1) inhibitor 0

(2) Additional Compounds for UBA6 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
NSC 624206
13116-77-3

(3) Tocris Compounds for UBA6 Gene

Compound Action Cas Number
NSC 624206 Ubiquitin-activating enzyme (E1) inhibitor 13116-77-3
PYR 41 Ubiquitin-activating enzyme (E1) inhibitor 418805-02-4
PYZD 4409 Ubiquitin-activating enzyme (E1) inhibitor 423148-78-1

(1) ApexBio Compounds for UBA6 Gene

Compound Action Cas Number
PYZD-4409 E1 enzyme inhibitor 423148-78-1
genes like me logo Genes that share compounds with UBA6: view

Drug Products

Transcripts for UBA6 Gene

Unigene Clusters for UBA6 Gene

Ubiquitin-like modifier activating enzyme 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBA6 Gene

No ASD Table

Relevant External Links for UBA6 Gene

GeneLoc Exon Structure for
UBA6
ECgene alternative splicing isoforms for
UBA6

Expression for UBA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBA6 Gene

Protein differential expression in normal tissues from HIPED for UBA6 Gene

This gene is overexpressed in Lymph node (12.6) and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBA6 Gene



Protein tissue co-expression partners for UBA6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBA6 Gene:

UBA6

SOURCE GeneReport for Unigene cluster for UBA6 Gene:

Hs.212774

mRNA Expression by UniProt/SwissProt for UBA6 Gene:

A0AVT1-UBA6_HUMAN
Tissue specificity: Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.

Evidence on tissue expression from TISSUES for UBA6 Gene

  • Nervous system(4.5)
  • Liver(4.4)
  • Blood(4.2)
  • Muscle(4.2)
  • Heart(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with UBA6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBA6 Gene

Orthologs for UBA6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBA6 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia UBA6 34 35
  • 92.4 (n)
cow
(Bos Taurus)
Mammalia UBA6 34 35
  • 92.05 (n)
mouse
(Mus musculus)
Mammalia Uba6 34 16 35
  • 88.24 (n)
rat
(Rattus norvegicus)
Mammalia Uba6 34
  • 88.02 (n)
oppossum
(Monodelphis domestica)
Mammalia UBA6 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBA6 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBA6 34 35
  • 78.09 (n)
lizard
(Anolis carolinensis)
Reptilia UBA6 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uba6 34
  • 73.21 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13897 34
zebrafish
(Danio rerio)
Actinopterygii si:dkey-82j4.2 34
  • 65.36 (n)
UBA6 35
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Uba1 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uba-1 35
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBA1 35
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
Species where no ortholog for UBA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBA6 Gene

ENSEMBL:
Gene Tree for UBA6 (if available)
TreeFam:
Gene Tree for UBA6 (if available)

Paralogs for UBA6 Gene

Paralogs for UBA6 Gene

(3) SIMAP similar genes for UBA6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UBA6: view

Variants for UBA6 Gene

Sequence variations from dbSNP and Humsavar for UBA6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000066393 -- 67,638,319(+) GCAGC(C/T)GAAGC intron-variant
rs1000070239 -- 67,686,580(+) ACAGA(C/T)AGACA intron-variant
rs1000082020 -- 67,670,824(+) CAGCA(C/T)ATCAT intron-variant
rs1000095481 -- 67,638,589(+) AGTGG(A/G)ACTCA intron-variant
rs1000110873 -- 67,696,571(+) GGTAT(A/C)TTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBA6 Gene

Variant ID Type Subtype PubMed ID
esv3372953 CNV insertion 20981092
nsv1114541 CNV deletion 24896259

Variation tolerance for UBA6 Gene

Residual Variation Intolerance Score: 7.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.74; 83.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBA6 Gene

Disorders for UBA6 Gene

Relevant External Links for UBA6

Genetic Association Database (GAD)
UBA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBA6

No disorders were found for UBA6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBA6 Gene

Publications for UBA6 Gene

  1. UBE1L2, a novel E1 enzyme specific for ubiquitin. (PMID: 17580310) Pelzer C. … Groettrup M. (J. Biol. Chem. 2007) 2 3 22 64
  2. Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. (PMID: 17597759) Jin J. … Harper J.W. (Nature 2007) 3 4 64
  3. E1-L2 activates both ubiquitin and FAT10. (PMID: 17889673) Chiu Y.-H. … Chen Z.J. (Mol. Cell 2007) 3 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for UBA6 Gene

Sources for UBA6 Gene

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