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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBA52 Gene

protein-coding   GIFtS: 59
GCID: GC19P018682

Ubiquitin A-52 Residue Ribosomal Protein Fusion Product...

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 11 2 3     Ribosomal Protein L401
60S Ribosomal Protein L401 2     HUBCEP522
Ubiquitin Carboxyl Extension Protein 521 2     L402
Ubiquitin-52 Amino Acid Fusion Protein1 2     RPL402
ubiquitin-CEP521 2     Ubiquitin-60S Ribosomal Protein L402
CEP522 3     UBCEP23

External Ids:    HGNC: 124581   Entrez Gene: 73112   Ensembl: ENSG000002219837   OMIM: 1913215   UniProtKB: P629873   

Export aliases for UBA52 gene to outside databases

Previous GC identifers: GC19P019176 GC19P019074 GC19P018527 GC19P018545 GC19P018546 GC19P018548 GC19P018245


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBA52 Gene:
Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular
proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure,
the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein
consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene
encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a
C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the
genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBA52 Gene: 
UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1) is a protein-coding gene. Diseases associated with UBA52 include malignant skin fibrous histiocytoma, and apocrine adenoma, and among its related super-pathways are Eukaryotic Translation Initiation and Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase. GO annotations related to this gene include protein binding and structural constituent of ribosome. An important paralog of this gene is UBB.

UniProtKB/Swiss-Prot: RL40_HUMAN, P62987
Function: Ubiquitin: exists either covalently attached to another protein, or free (unanchored). When covalently
bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer
linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the
initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target
protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may
be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and
in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase
modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in
endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription
factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.
Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or
Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct
roles, such as in activation of protein kinases, and in signaling
Function: 60S ribosomal protein L40: component of the 60S subunit of the ribosome. Ribosomal protein L40 is
essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of
vesicular stomatitis virus mRNAs

Gene Wiki entry for UBA52 (Ubiquitin A-52 residue ribosomal protein fusion product 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBA52 gene promoter:
         AhR   Lmo2   CUTL1   HNF-4alpha2   Tal-1beta   c-Ets-1   E47   HNF-4alpha1   Arnt   MRF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UBA52

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBA52


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1-p12   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.1-p12

UBA52 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBA52 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P018682:  view genomic region     (about GC identifiers)

Start:
18,682,540 bp from pter      End:
18,688,360 bp from pter
Size:
5,821 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RL40_HUMAN, P62987 (See protein sequence)
Recommended Name: Ubiquitin-60S ribosomal protein L40 precursor  
Size: 128 amino acids; 14728 Da
Subunit: Ribosomal protein L40 is part of the 60S ribosomal subunit (By similarity)
Subcellular location: Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity)
Subcellular location: 60S ribosomal protein L40: Cytoplasm (By similarity)
Miscellaneous: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of
ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin
precursor with exact head to tail repeats, the number of repeats differ between species and strains
Miscellaneous: For a better understanding, features related to ubiquitin are only indicated for the first chain
Sequence caution: Sequence=AAK31162.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for UBA52:
2LJ5 (3D)        2RSU (3D)        3J3B (3D)        4HJK (3D)    
Secondary accessions: P02248 P02249 P02250 P14793 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887
Q91888 Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Explore the universe of human proteins at neXtProt for UBA52: NX_P62987

Explore proteomics data for UBA52 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62987

  • UBA52 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBA52 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001029102.1  NP_003324.1  

    ENSEMBL proteins: 
     ENSP00000472264   ENSP00000396910   ENSP00000471062   ENSP00000388107   ENSP00000470419  
     ENSP00000472137   ENSP00000471622   ENSP00000472545   ENSP00000470507   ENSP00000473048  
     ENSP00000471464   ENSP00000472768   ENSP00000471991  
    Reactome Protein details: P62987
    Human Recombinant Protein Products for UBA52: 
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    Novus Biologicals UBA52 Protein
    Novus Biologicals UBA52 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBA52 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005765lysosomal membrane IDA17897319
    GO:0005829cytosol TAS--
    GO:0005840ribosome IEA--
    GO:0005886plasma membrane TAS--

    UBA52 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPL: L ribosomal proteins

    5 InterPro protein domains:
     IPR001975 Ribosomal_L40e
     IPR019956 Ubiquitin_subgr
     IPR019954 Ubiquitin_CS
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry P62987

    ProtoNet protein and cluster: P62987

    UniProtKB/Swiss-Prot: RL40_HUMAN, P62987
    Similarity: In the N-terminal section; belongs to the ubiquitin family
    Similarity: In the C-terminal section; belongs to the ribosomal protein L40e family
    Similarity: Contains 1 ubiquitin-like domain


    UBA52 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RL40_HUMAN, P62987
    Function: Ubiquitin: exists either covalently attached to another protein, or free (unanchored). When covalently
    bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer
    linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the
    initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target
    protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may
    be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and
    in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase
    modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in
    endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription
    factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.
    Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or
    Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct
    roles, such as in activation of protein kinases, and in signaling
    Function: 60S ribosomal protein L40: component of the 60S subunit of the ribosome. Ribosomal protein L40 is
    essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of
    vesicular stomatitis virus mRNAs

         Genatlas biochemistry entry for UBA52:
    ubiquitin-ribosomal protein fusion

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0005515protein binding IPI15936278
         
    UBA52 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for UBA52:
     Decreased G3BP1 protein expres  Decreased cell number, increas  S arrest  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBA52 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBA52

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBA52 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBA52 

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBA52


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBA52 About   (see all 74)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Viral mRNA Translation
    Influenza Life Cycle0.95
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Influenza Infection0.95
    3' -UTR-mediated translational regulation0.93
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Formation of a pool of free 40S subunits0.90
    Eukaryotic Translation Termination0.94
    Nonsense-Mediated Decay0.84
    2Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC-Cdc20 mediated degradation of Nek2A0.78
    Common schema of ubiquitination0.36
    APC/C:Cdc20 mediated degradation of Cyclin B0.76
    3Cell cycle Transition and termination of DNA replacation
    Cell cycle Transition and termination of DNA replacation0.95
    Cell cycle Transition and termination of DNA replication0.95
    4CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Vif-mediated degradation of APOBEC3G0.89
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    SCF(Skp2)-mediated degradation of p27/p210.89
    CDK-mediated phosphorylation and removal of Cdc60.94
    Removal of licensing factors from origins0.89
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    Regulation of DNA replication0.89
    5Signal Transduction
    Signal Transduction0.50
    Signaling by NOTCH0.50
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.50
    Signaling by NOTCH10.50
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.50
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.50
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.50
    Signaling by NOTCH0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/19 EMD Millipore Pathways for UBA52 (see all 19)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Meiosis
    Proteolysis Putative SUMO-1 pathway
    Proteolysis Putative ubiquitin pathway
    Immune response IL-1 signaling pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for UBA52
        NF-KappaB (p50-p65) Pathway

    5/24 GeneGo (Thomson Reuters) Pathways for UBA52 (see all 24)
        Normal wtCFTR traffic / Sorting endosome formation
    Proteolysis Putative ubiquitin pathway
    Immune response MIF-JAB1 signaling
    Regulation of degradation of wt-CFTR
    Immune response IL-12 signaling pathway

    2 BioSystems Pathways for UBA52
        DNA Replication
    Cytoplasmic Ribosomal Proteins

    5/228        Reactome Pathways for UBA52 (see all 228)
        NOTCH1 Intracellular Domain Regulates Transcription
    TGF-beta receptor signaling activates SMADs
    Toll Like Receptor 2 (TLR2) Cascade
    Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
    Regulation of innate immune responses to cytosolic DNA


    1         Kegg Pathway  (Kegg details for UBA52):
        Ribosome


    UBA52 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBA52

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/687 Interacting proteins for UBA52 (P629872, 3 ENSP000003881074) via UniProtKB, MINT, STRING, and/or I2D (see all 687)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/77 biological process terms (GO ID links to tree view) (see all 77):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000187activation of MAPK activity TAS--
    GO:0000209protein polyubiquitination TAS--

    UBA52 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for UBA52:
    Small Molecule - inhibitor
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    Browse Tocris compounds for UBA52 (RL40)

    Search CenterWatch for drugs/clinical trials and news about UBA52 / RL40

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBA52 gene (2 alternative transcripts): 
    NM_001033930.1  NM_003333.3  

    Unigene Cluster for UBA52:

    Ubiquitin A-52 residue ribosomal protein fusion product 1
    Hs.5308  [show with all ESTs]
    Unigene Representative Sequence: NM_001033930
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000596304 ENST00000430157(uc002njs.3) ENST00000596273 ENST00000598814
    ENST00000442744(uc002njr.3) ENST00000595683 ENST00000599256 ENST00000595158
    ENST00000598780 ENST00000599551 ENST00000597451 ENST00000599595 ENST00000596272
    ENST00000594527
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBA52

    Additional mRNA sequence: 

    AF348700.1 AF545864.1 AK057790.1 AK314717.1 BC101830.1 BC101832.1 BC143668.1 X56998.1 
    X56999.1 Y00361.1 

    24/54 DOTS entries (see all 54):

    DT.100834067  DT.100701381  DT.91770700  DT.91674003  DT.91786700  DT.100045216  DT.100701383  DT.100701386 
    DT.95085246  DT.99955604  DT.453583  DT.95159168  DT.91770707  DT.95159231  DT.401373  DT.97775328 
    DT.121499143  DT.95211950  DT.121499141  DT.100771856  DT.121499113  DT.121499107  DT.95159124  DT.100701390 

    24/1424 AceView cDNA sequences (see all 1424):

    CB111746 AI707583 C02165 AI745460 AA316624 BM827793 F31321 BG315283 
    AI928441 F31808 BI868226 BM911507 BQ677516 H13978 AJ574072 BG686419 
    BQ647093 BQ928332 F22834 AA331302 N39284 F26416 CA427700 BG759140 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBA52 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATCTTTG
    UBA52 Expression
    About this image


    See UBA52 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBA52

    SOURCE GeneReport for Unigene cluster: Hs.5308
        SABiosciences Custom PCR Arrays for UBA52
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBA52 gene from 10/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uba521 , 5 ubiquitin A-52 residue ribosomal protein fusion product more1, 5 90.36(n)1
    100(a)1
      8 (34.15 cM)5
    221861  NM_019883.31  NP_063936.11 
     705082635 
    chicken
    (Gallus gallus)
    Aves UBA521 ubiquitin A-52 residue ribosomal protein fusion product more 87.24(n)
    98.44(a)
      395958  NM_205075.1  NP_990406.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBA526
    --
    Uncharacterized protein
    81(a)
    100(a)
    1 ↔ 1
    possible ortholog
    6(46144862-46145068)
    LGb(1336411-1336527)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.334012 Xenopus laevis transcribed sequence with strong similarity more 87.12(n)    BM191423.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa91f082 Transcribed sequence with strong similarity to protein more 85.57(n)    BQ419441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubi-p63E3
    RpL401
    response to heat protein degradation
    tagging3
    Ribosomal protein L401
    100(a)3
    84.9(n)1
    97.66(a)1
      3 63F53
    336291  NM_057428.31  NP_476776.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ubq-21 , 3 UBQ-2 ubiquitin\; 60S Ribosomal protein
    L403
    Protein UBQ-21
    92(a)3
    78.39(n)1
    92.97(a)1
      III(13049293-13049805)3
    1767181  NM_067294.21  NP_499695.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL40A1 Rpl40ap 72.14(n)
    89.84(a)
      854658   NP_012118.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBQ11 60S ribosomal protein L40-2 78.91(n)
    92.19(a)
      824425  NM_115119.3  NP_566969.1 
    rice
    (Oryza sativa)
    Liliopsida Os.127722 Oryza sativa (japonica cultivar-group) mRNA for ubiquitin/ribosomal more 81.84(n)    D12629.1 


    ENSEMBL Gene Tree for UBA52 (if available)
    TreeFam Gene Tree for UBA52 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBA52 gene
    UBB2  UBC2  UBBP42  
    14 SIMAP similar genes for UBA52 using alignment to 5 protein entries:     RL40_HUMAN (see all proteins):
    DKFZp434K0435    RPS27A    UBB    UBC    UbC    UBBP4
    NEDD8-MDP1    NEDD8    FAU    ZFAND4    UBL4A    PARK2
    RAD23A    ISG15

    UBA52 for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for UBA52 (see all 11)
    PGOHUM00000239585 PGOHUM00000248046 PGOHUM00000248185 PGOHUM00000248885 PGOHUM00000234907


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/211 SNPs in UBA52 are shown (see all 211)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104059751,2
    C--18613591(+) cagaaC/Ttgctt 2 -- us2k10--------
    rs1432717971,2
    C--18613633(+) AGATCA/GCACCA 2 -- us2k10--------
    rs1925801001,2
    C--18613724(+) CAGACA/GTGAGA 2 -- us2k10--------
    rs1126038591,2
    C--18613730(+) TGAGAG/ATGTCT 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs2009791411,2
    --18613853(+) TTTTT-/GTTTTG 2 -- us2k10--------
    rs2009299361,2
    C--18613858(+) TTTTTG/TTTTTG 2 -- us2k10--------
    rs1508311661,2
    --18613888(+) CTGTTG/TCCCAG 2 -- us2k10--------
    rs1832151321,2
    --18613900(+) CTGGAA/GTGCAG 2 -- us2k10--------
    rs558883661,2
    C,F--18613960(+) CCTCCT/CGCCTC 2 -- us2k18Minor allele frequency- C:0.50WA NA CSA EA 368
    rs1392372501,2
    C--18613989(+) AGGTGC/GGCACC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBA52 (18682540 - 18688360 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for UBA52:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833776CNV Loss17160897
    nsv911283CNV Loss21882294
    dgv3784n71CNV Loss21882294
    nsv911282CNV Loss21882294
    nsv911274CNV Loss21882294
    nsv911281CNV Loss21882294
    nsv911284CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 191321    OMIM disorders: --

    20/21 diseases for UBA52 (see all 21):    About MalaCards
    malignant skin fibrous histiocytoma    apocrine adenoma    cavernous hemangioma    gastrointestinal system disease
    aphasia    paget's disease of bone    frontotemporal dementia    hemangioma
    fibrous histiocytoma    histiocytoma    angelman syndrome    dementia
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    fanconi's anemia    hypoxia
    adenoma    influenza    anemia    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for UBA52:
    Apocrine adenoma

    UBA52 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for UBA52 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBA52 gene, integrated from 9 sources (see all 92):
    (articles sorted by number of sources associating them with UBA52)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes. (PubMed id 1850507)1, 2, 9 Baker R.T. and Board P.G. (1991)
    2. Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12. (PubMed id 8188300)1, 3, 9 Webb G.C....Board P.G. (1994)
    3. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)1, 2 Vasilescu J.... Figeys D. (2007)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. cDNA encoding a human homolog of yeast ubiquitin 1. (PubMed id 3037496)1, 2 Salvesen G.... Farley D. (1987)
    6. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (2013)
    7. A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs. (PubMed id 23169626)2 Lee A.S.... Whelan S.P. (2013)
    8. Novel, gel-free proteomics approach identifies RNF5 an d JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (2013)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7311 HGNC: 12458 AceView: UBA52 Ensembl:ENSG00000221983 euGenes: HUgn7311
    ECgene: UBA52 Kegg: 7311 H-InvDB: UBA52

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBA52 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBA52 gene:
    Search GeneIP for patents involving UBA52

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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