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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UBA52 Gene

protein-coding GIFtS: 59
GCID: GC19P018682

ubiquitin A-52 residue ribosomal protein fusion product...

Explore 18 diseases affiliated with
UBA52 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1¹ ² ³		MGC57125¹
CEP52¹ ² ³		60S Ribosomal Protein L40²
HUBCEP52¹ ²		Ubiquitin Carboxyl Extension Protein 52²
L40¹ ²		Ubiquitin-52 Amino Acid Fusion Protein²
RPL40¹ ²		Ubiquitin-60S Ribosomal Protein L40²
MGC126879¹		Ubiquitin-CEP52¹
MGC126881¹		UBCEP2³

External Ids:	HGNC: 12458¹	Entrez Gene: 7311²	Ensembl: ENSG00000221983⁷	OMIM: 191321⁵	UniProtKB: P62987³

Export aliases for UBA52 gene to outside databases

Previous GC identifers: GC19P019176 GC19P019074 GC19P018527 GC19P018545 GC19P018546 GC19P018548 GC19P018245

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBA52:

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins

for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation

of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either

polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein

consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein

(CEP). Multiple processed pseudogenes derived from this gene are present in the genome. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RL40_HUMAN, P62987

Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound,

it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via

different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the

ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different

functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair;

Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation;

Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is

involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as

well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains

formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of

target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is

free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in

signaling

Function: Ribosomal protein L40 is a component of the 60S subunit of the ribosome

Gene Wiki entry for UBA52 (Ubiquitin A-52 residue ribosomal protein fusion product 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UBA52 gene promoter:
AhR Lmo2 CUTL1 HNF-4alpha2 Tal-1beta c-Ets-1 E47 HNF-4alpha1 Arnt MRF-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for UBA52

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBA52

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1-p12 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.1-p12

UBA52 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBA52 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P018682: view genomic region (about GC identifiers)

Start:	18,682,614 bp from pter	End:	18,688,270 bp from pter
Size:	5,657 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RL40_HUMAN, P62987 (See protein sequence)

Recommended Name: Ubiquitin-60S ribosomal protein L40 precursor

Size: 128 amino acids; 14728 Da

Subunit: Ribosomal protein L40 is part of the 60S ribosomal subunit (By similarity)

Subcellular location: Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity)

Subcellular location: 60S ribosomal protein L40: Cytoplasm (By similarity)

Miscellaneous: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin

fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with

exact head to tail repeats, the number of repeats differ between species and strains

Miscellaneous: For a better understanding, features related to ubiquitin are only indicated for the first chain

Sequence caution: Sequence=AAK31162.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

2 PDB 3D structures from and Proteopedia for UBA52:

2LJ5 (3D)

4HJK (3D)

Secondary accessions: P02248 P02249 P02250 P14793 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888

Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Explore the universe of human proteins at neXtProt for UBA52: NX_P62987

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P62987

UBA52 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001029102.1 NP_003324.1

ENSEMBL proteins:

ENSP00000388107 ENSP00000396910

Reactome Protein details: P62987
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: UBA52 OriGene Protein Over-expression Lysate (see all 3): UBA52 OriGene Custom Protein Services for UBA52
	GenScript Custom Purified and Recombinant Proteins Services for UBA52
	Novus Biologicals UBA52 Protein Novus Biologicals UBA52 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for UBA52

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--
GO:0005840	ribosome	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0010008	endosome membrane	TAS	--

UBA52 for ontologies About GeneDecksing

UBA52 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): UBA52 OriGene Custom Antibody Services for UBA52
	GenScript Superior Antibodies for UBA52
	Novus Biologicals UBA52 Antibodies
	Abcam antibodies for UBA52
	Uscn Antibodies for UBA52
	ThermoFisher Antibody for UBA52

Assay Products for UBA52:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for UBA52
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for UBA52

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UBA52 for domains About GeneDecksing

5 InterPro domains/families:

IPR001975 Ribosomal_L40e

IPR019956 Ubiquitin_subgr

IPR019954 Ubiquitin_CS

IPR000626 Ubiquitin

IPR019955 Ubiquitin_supergroup

Graphical View of Domain Structure for InterPro Entry P62987

ProtoNet protein and cluster: P62987

UniProtKB/Swiss-Prot: RL40_HUMAN, P62987

Similarity: In the N-terminal section; belongs to the ubiquitin family

Similarity: In the C-terminal section; belongs to the ribosomal protein L40e family

Similarity: Contains 1 ubiquitin-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: