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Aliases & Descriptions for UBA5
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FLJ17281 2 FLJ23251 1 , 2 FLJ23251UBA5 2 THIFP1 2 ThiFP1 3 UBE1DC1 2 , 3 , 5
Descriptions UBA5, ubiquitin-activating enzyme E1 homolog 2 UFM1-activating enzyme 2 , 3 Ubiquitin-activating enzyme 5 2 , 3 Ubiquitin-activating enzyme E1 domain-containing protein 1 3 ubiquitin-activating enzyme E1-domain containing 1 1 , 2 ubiquitin-like modifier activating enzyme 5 2
Search outside databases for aliases for UBA5 gene
Summaries for UBA5 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for UBA5 : This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This proteinactivates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via theformation of a high-energy thioester bond. Two alternatively spliced transcript variants encodingdistinct isoforms have been found for this gene. A pseudogene located on chromosome 1 has alsobeen identified. [provided by RefSeq] UniProtKB/Swiss-Prot: UBA5_HUMAN, Q9GZZ9 Function : E1-like enzyme which activates UFM1
Gene Wiki entry for UBA5 (UBE1DC1)
Genomic Location for UBA5
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3q22.1 Ensembl cytogenetic band: 3q22.1 HGNC cytogenetic band: 3q22 UBA5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P133862:
(about GC identifiers )
Start:
133,861,836 bp from pter
End:
133,879,312 bp from pter
Size:
17,477 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000003.10 NT_005612.15 Proteins for UBA5
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: UBA5_HUMAN, Q9GZZ9 (See
protein sequence )Recommended Name: Ubiquitin-like modifier-activating enzyme 5 Size : 404 amino acids; 44863 Da
Secondary accessions : Q96ST1
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_079094.1 NP_938143.1 ENSEMBL proteins: ENSP00000348565 ENSP00000376839 ENSP00000264991 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for UBA5: Assays for UBA5:
Protein
Domains/ Families for UBA5(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9GZZ9 ProtoNet protein and cluster: Q9GZZ9
1 Blocks protein family : IPB000594 UBA/THIF-type NAD/FAD binding fold UniProtKB/Swiss-Prot: UBA5_HUMAN, Q9GZZ9 Similarity : Belongs to the ubiquitin-activating E1 family. UBA5 subfamily
Gene Function for UBA5
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_198329 Applied Biosystems Silencer ® siRNAs for UBA5 Sigma-Aldrich siRNA and siRNA Panels for UBA5 Sigma-Aldrich shRNA for UBA5 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_024818                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_024818                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_024818  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024818 UniProtKB/Swiss-Prot: UBA5_HUMAN, Q9GZZ9 Function : E1-like enzyme which activates UFM1
2 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for UBA5
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/8 Interacting proteins for UBA5 (ENSP00000348565 3 Q9GZZ9 2 ) via UniProtKB, MINT, and/or STRING (see all 8
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008152 metabolic process
IEA -- GO:0019941 modification-dependent protein catabolic process
IEA --
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Drugs & Compounds for UBA5 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
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Browse Tocris compounds for UBA5
Transcripts for UBA5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_198329 Sigma-Aldrich siRNA and siRNA Panels for UBA5 Sigma-Aldrich shRNA for UBA5 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_024818 NM_198329
REFSEQ mRNAs for UBA5 gene (2 alternative transcripts): NM_024818.3 NM_198329.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_024818 NM_198329
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_024818                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_024818                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_024818  
Additional cDNA sequence: AB154406.1 AK026904.1 AK027563.1 AK056238.1 AK129616.1 AL136757.1 AY253672.1 BC009737.1 BC048015.1 BX537742.1 CR615958.1
18 DOTS entries : DT.97780080 DT.113449 DT.100794372 DT.101982431 DT.95357113 DT.95203841 DT.120924343 DT.99980399 DT.97843257 DT.97843254 DT.120924319 DT.120924352 DT.120944529 DT.91742338 DT.95163642 DT.120924360 DT.92432853 DT.95163640
24/191 AceView cDNA sequences (see all 191
):BM714610 AW169967 AI570379 BQ576131 BM504192 AI799509 AL707384 AI473675 AA348650 AA433980 BM697556 BX495490 AL136757 AB154406 BG617059 CR615958 AA902992 CA414904 AA452533 CB150461 BU071370 BE140268 CD679386 NM_198329
Unigene Cluster for UBA5: Ubiquitin-like modifier activating enzyme 5 Hs.170737 [show with all ESTs ] Unigene Representative Sequence: NM_024818 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UBA5 (see all 7
) ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 SP1 :       -   -       -                               SP2 :           -   -   -                               SP3 :               -                               SP4 :               -                               SP5 :                                            
About this scheme ECgene alternative splicing isoforms for UBA5 3 Ensembl transcripts including schematic representations : ENST00000356232
ENST00000393131
ENST00000264991
Expression for UBA5
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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UBA5 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for UBA5 1 / 2
8 probe-sets matching UBA5 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GGGACGCCCGSOURCE GeneReport for Unigene cluster: Hs.170737
Orthologs for UBA5
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for UBA5 gene from 5/20 species (see all 20
)
About this table Species with no ortholog for UBA5 ENSEMBL Gene Tree for UBA5 Paralogs for UBA5 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for UBA5 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for UBA5 (up to first 250kb)
Disorders & Mutations for UBA5
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 610552
Medical News for UBA5 (Possibly Related Articles in
Doctor's Guide )
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Publications for UBA5 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/15 PubMed articles for UBA5 gene (see all 15
): A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. (PubMed id 15071506) 2, 3, 4 Komatsu M....Tanaka K. (2004) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 2, 3, 4 Wiemann S.... Poustka A. (2001) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Isolation and characterization of ubiquitin-activating enzyme E1-domain containing 1, UBE1DC1. (PubMed id 16328888) 1, 3 Dou T....Mao Y. (2005) UBE1DC1, an ubiquitin-activating enzyme, activates two different ubiquitin-like proteins. (PubMed id 18442052) 3 Zheng M....Mao Y. (2008) The LIFEdb database in 2006. (PubMed id 16381901) 3 Mehrle A....Wiemann S. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 3 Kimura K.... Sugano S. (2006) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 3 Rual J.F....Vidal M. (2005) From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336) 3 Wiemann S....Poustka A. (2004)
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Genome Databases showing UBA5
(According to
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Ensembl ,
miRBase ,
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and/or
H-InvDB )
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Specialized Databases showing UBA5 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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