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Aliases for UBA5 Gene

Aliases for UBA5 Gene

  • Ubiquitin Like Modifier Activating Enzyme 5 2 3
  • Ubiquitin-Like Modifier Activating Enzyme 5 2 3 5
  • Ubiquitin-Activating Enzyme E1 Domain-Containing Protein 1 3 4
  • Ubiquitin-Activating Enzyme E1-Domain Containing 1 2 3
  • Ubiquitin-Activating Enzyme 5 3 4
  • UFM1-Activating Enzyme 3 4
  • UBE1DC1 3 4
  • THIFP1 3 4
  • Ubiquitin-Activating Enzyme E1 Homolog (Yeast) 2
  • UBA5, Ubiquitin-Activating Enzyme E1 Homolog 3
  • UBA5 2

External Ids for UBA5 Gene

Previous HGNC Symbols for UBA5 Gene

  • UBE1DC1

Previous GeneCards Identifiers for UBA5 Gene

  • GC03P133862
  • GC03P132373
  • GC03P129753

Summaries for UBA5 Gene

Entrez Gene Summary for UBA5 Gene

  • This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been identified on chromosome 1. [provided by RefSeq, Feb 2016]

GeneCards Summary for UBA5 Gene

UBA5 (Ubiquitin Like Modifier Activating Enzyme 5) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Remodeling of Adherens Junctions. GO annotations related to this gene include UFM1 activating enzyme activity. An important paralog of this gene is MOCS3.

UniProtKB/Swiss-Prot for UBA5 Gene

  • E1-like enzyme which activates UFM1 and SUMO2.

Gene Wiki entry for UBA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBA5 Gene

Genomics for UBA5 Gene

Regulatory Elements for UBA5 Gene

Enhancers for UBA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBA5 Gene

132,654,446 bp from pter
132,678,253 bp from pter
23,808 bases
Plus strand

Genomic View for UBA5 Gene

Genes around UBA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBA5 Gene

Proteins for UBA5 Gene

  • Protein details for UBA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-like modifier-activating enzyme 5
    Protein Accession:
    Secondary Accessions:
    • A6NJL3
    • D3DNC8
    • Q96ST1

    Protein attributes for UBA5 Gene

    404 amino acids
    Molecular mass:
    44863 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBA5 Gene

    Alternative splice isoforms for UBA5 Gene


neXtProt entry for UBA5 Gene

Proteomics data for UBA5 Gene at MOPED

Post-translational modifications for UBA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for UBA5 Gene

Domains & Families for UBA5 Gene

Gene Families for UBA5 Gene

Protein Domains for UBA5 Gene

Suggested Antigen Peptide Sequences for UBA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
  • Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
genes like me logo Genes that share domains with UBA5: view

Function for UBA5 Gene

Molecular function for UBA5 Gene

UniProtKB/Swiss-Prot Function:
E1-like enzyme which activates UFM1 and SUMO2.

Gene Ontology (GO) - Molecular Function for UBA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0061503 tRNA threonylcarbamoyladenosine dehydratase IBA --
genes like me logo Genes that share ontologies with UBA5: view
genes like me logo Genes that share phenotypes with UBA5: view

Animal Models for UBA5 Gene

MGI Knock Outs for UBA5:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBA5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBA5 Gene

Localization for UBA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBA5 Gene

Cytoplasm. Nucleus. Note=Localizes mainly in cytoplasm, while it mainly localizes to the nucleus in presence of SUMO2.

Subcellular locations from

Jensen Localization Image for UBA5 Gene COMPARTMENTS Subcellular localization image for UBA5 gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for UBA5 Gene

Pathways & Interactions for UBA5 Gene

genes like me logo Genes that share pathways with UBA5: view

Gene Ontology (GO) - Biological Process for UBA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0034976 response to endoplasmic reticulum stress IDA 23152784
genes like me logo Genes that share ontologies with UBA5: view

No data available for SIGNOR curated interactions for UBA5 Gene

Drugs & Compounds for UBA5 Gene

No Compound Related Data Available

Transcripts for UBA5 Gene

Unigene Clusters for UBA5 Gene

Ubiquitin-like modifier activating enzyme 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBA5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - -
SP3: -
SP4: -
SP6: - - - - -

Relevant External Links for UBA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBA5 Gene

mRNA expression in normal human tissues for UBA5 Gene

Protein differential expression in normal tissues from HIPED for UBA5 Gene

This gene is overexpressed in Skin (13.2) and Salivary gland (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBA5 Gene

SOURCE GeneReport for Unigene cluster for UBA5 Gene Hs.170737

mRNA Expression by UniProt/SwissProt for UBA5 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with UBA5: view

Protein tissue co-expression partners for UBA5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBA5 Gene

Orthologs for UBA5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBA5 35
  • 92.99 (n)
  • 94.55 (a)
UBA5 36
  • 95 (a)
(Canis familiaris)
Mammalia UBA5 35
  • 93.32 (n)
  • 96.04 (a)
UBA5 36
  • 91 (a)
(Mus musculus)
Mammalia Uba5 35
  • 85.49 (n)
  • 88.31 (a)
Uba5 16
Uba5 36
  • 88 (a)
(Pan troglodytes)
Mammalia UBA5 35
  • 99.34 (n)
  • 99.5 (a)
UBA5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Uba5 35
  • 86.07 (n)
  • 88.56 (a)
(Monodelphis domestica)
Mammalia UBA5 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
-- 36
  • 89 (a)
(Gallus gallus)
Aves UBA5 35
  • 79.51 (n)
  • 85.39 (a)
UBA5 36
  • 84 (a)
(Anolis carolinensis)
Reptilia UBA5 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11058 35
uba5 35
  • 74.71 (n)
  • 80.9 (a)
(Danio rerio)
Actinopterygii -- 35
uba5 35
  • 70.45 (n)
  • 81.06 (a)
uba5 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009012 35
  • 61.67 (n)
  • 68.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1749 35
  • 63.35 (n)
  • 67.6 (a)
CG1749 36
  • 64 (a)
(Caenorhabditis elegans)
Secernentea T03F1.1 35
  • 64.45 (n)
  • 73.08 (a)
uba-5 36
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBA4 36
  • 17 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G05350 35
  • 60.47 (n)
  • 61.75 (a)
(Glycine max)
eudicotyledons Gma.6428 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8934 35
(Hordeum vulgare)
Liliopsida Hv.8523 35
(Oryza sativa)
Liliopsida Os.10838 35
Os02g0506500 35
  • 65.72 (n)
  • 70.82 (a)
(Triticum aestivum)
Liliopsida Ta.12503 35
(Zea mays)
Liliopsida Zm.4992 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14028 35
Species with no ortholog for UBA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UBA5 Gene

Gene Tree for UBA5 (if available)
Gene Tree for UBA5 (if available)

Paralogs for UBA5 Gene

Paralogs for UBA5 Gene Pseudogenes for UBA5 Gene

genes like me logo Genes that share paralogs with UBA5: view

Variants for UBA5 Gene

Structural Variations from Database of Genomic Variants (DGV) for UBA5 Gene

Variant ID Type Subtype PubMed ID
nsv4014 CNV Insertion 18451855

Variation tolerance for UBA5 Gene

Residual Variation Intolerance Score: 37.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 49.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for UBA5 Gene

Disorders for UBA5 Gene

Relevant External Links for UBA5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBA5 Gene

Publications for UBA5 Gene

  1. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. (PMID: 15071506) Komatsu M. … Tanaka K. (EMBO J. 2004) 2 3 4 67
  2. Isolation and characterization of ubiquitin-activating enzyme E1- domain containing 1, UBE1DC1. (PMID: 16328888) Dou T. … Mao Y. (Mol. Biol. Rep. 2005) 3 23
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for UBA5 Gene

Sources for UBA5 Gene