UBA3 Gene
protein-coding GIFtS: 61
GCID: GC03M069103
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|
ubiquitin-like modifier activating enzyme 3(Previous names: ubiquitin-activating enzyme E1C (homologous to yeast UBA3),...)
(Previous symbol: UBE1C)
| |
Aliases
for UBA3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Like Modifier Activating Enzyme 31 2 | | HUBA31 | | UBE1C1 2 3 | | NEDD8-Activating Enzyme E1 Catalytic Subunit2 | | Ubiquitin-Activating Enzyme E1C (Homologous To Yeast UBA3)1 2 | | Nedd8-Activating Enzyme HUba32 | | Ubiquitin-Activating Enzyme E1C (UBA3 Homolog, Yeast)1 2 | | UBA3, Ubiquitin-Activating Enzyme E1 Homolog2 | | Ubiquitin-Activating Enzyme 32 3 | | EC 6.3.2.-3 | | Ubiquitin-Like Modifier-Activating Enzyme 32 3 | | Ubiquitin-Activating Enzyme E1C3 | | NEDD8-Activating Enzyme E1C2 3 | | EC 6.3.28 | | HUba31 | | |
Export aliases for UBA3 gene to outside databasesPrevious GC identifer: GC03M069187 |
Summaries
for UBA3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBA3:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, orE1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of theE1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor proteinbinding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, whichregulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encodingdistinct isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: UBA3_HUMAN, Q8TBC4Function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminalglycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding aNEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulatessteroid receptor activity. Necessary for cell cycle progression
Gene Wiki entry for UBA3 (UBE1C)
|
Genomic Views
for UBA3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022459.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBA3 gene promoter:
MEF-2A RFX1 p53 aMEF-2 FOXL1 YY1 GATA-2 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBA3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBA3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p24.3-p13 Ensembl cytogenetic band: 3p14.1 HGNC cytogenetic band: 3p24.3-p13UBA3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M069103: view genomic region
(about GC identifiers)
Start:
|
69,103,881 bp from pter |
End:
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69,129,559 bp from pter |
Size:
|
25,679 bases |
Orientation:
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minus strand |
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Proteins
for UBA3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBA3_HUMAN, Q8TBC4 (See
protein sequence)Recommended Name: NEDD8-activating enzyme E1 catalytic subunit Size: 463 amino acids; 51852 Da
Subunit: Heterodimer of UBA3 and NAE1. Interacts with NEDD8, UBE2F and UBE2M. Binds ESR1 and ESR2 with bound steroidligand (By similarity). Interacts with TBATA (By similarity)
Miscellaneous: Arg-211 acts as a selectivity gate, preventing misactivation of ubiquitin by this NEDD8-specific E1complex
Sequence caution: Sequence=AAC27648.1; Type=Erroneous initiation;
6/12 PDB 3D structures from  and Proteopedia  for UBA3 (see all 12):1R4M (3D)
1R4N (3D)
1TT5 (3D)
1Y8X (3D)
1YOV (3D)
2LQ7 (3D)
Secondary accessions: A6NLB5 A8K027 O76088 Q9NTU3Alternative splicing: 2 isoforms: Q8TBC4-1 Q8TBC4-2 Explore the universe of human proteins at neXtProt for UBA3: NX_Q8TBC4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TBC4
4/15 DME Specific Peptides for UBA3 (Q8TBC4) (see all 15)
UBA3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_003959.3 NP_937838.1
ENSEMBL proteins: ENSP00000400294 ENSP00000354340 ENSP00000340041 ENSP00000417547 ENSP00000419077 ENSP00000440085 Reactome Protein details: Q8TBC4
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- |
UBA3 for ontologies About GeneDecksing
UBA3 Antibody Products:
Assay Products for UBA3: |
Protein
Domains /
Families
for UBA3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBA3 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q8TBC4ProtoNet protein and cluster: Q8TBC4 1 Blocks protein family: IPB000594 UBA/THIF-type NAD/FAD binding fold
UniProtKB/Swiss-Prot: UBA3_HUMAN, Q8TBC4Similarity: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily |
Function
for UBA3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBA3_HUMAN, Q8TBC4Function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminalglycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding aNEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulatessteroid receptor activity. Necessary for cell cycle progressionEnzyme regulation: Binding of TP53BP2 to the regulatory subunit NAE1 decreases activityEnzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBA3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBA3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBA3 (NM_006001) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBA3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBA3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBA3 |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
UBA3 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for UBA3:
Animal Models:
Mouse knock-out Uba3tm1Tchi for UBA3
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Uba3):
UBA3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for UBA3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | | | 3 | Coregulation of Androgen receptor activity | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for UBA3
4 
Reactome Pathways for UBA3
1 
Kegg Pathway (Kegg details for UBA3):
UniProtKB/Swiss-Prot: UBA3_HUMAN, Q8TBC4Pathway: Protein modification; protein neddylation
UBA3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBA3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/64 Interacting proteins for UBA3 (Q8TBC41, 2, 3 ENSP000003543404) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
UBA3 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBA3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBA3
Search CenterWatch for drugs/clinical trials and news about UBA3
|
Transcripts
for UBA3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBA3 gene (3 alternative transcripts): NM_003968.3 NM_198195.1 NM_198197.1 Unigene Cluster for UBA3: Ubiquitin-like modifier activating enzyme 3 Hs.154320 [show with all ESTs]Unigene Representative Sequence: NM_00396812 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000415609(uc011bfz.2) ENST00000361055(uc003dno.3) ENST00000349511(uc003dnq.3 uc011bfy.2)
ENST00000461934 ENST00000465627 ENST00000461522 ENST00000465108 ENST00000493957
ENST00000466763 ENST00000485424 ENST00000464605 ENST00000540295
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBA3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBA3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBA3 (NM_006001) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBA3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBA3 |
Additional cDNA sequence: AB012190.1 AF046024.1 AK002159.1 AK289392.1 AK298878.1 AK314751.1 AK316540.1 AL117566.1 BC022853.1 CR533537.1 24/33 DOTS entries (see all 33): DT.100824573 DT.95349004 DT.100824571 DT.452636 DT.120881860 DT.100673627 DT.120881849 DT.101984597 DT.120881856 DT.100824575 DT.99999886 DT.100008710 DT.100036654 DT.120881863 DT.91759473 DT.91759480 DT.92001678 DT.100036656 DT.100674495 DT.100824561 DT.100824563 DT.100824567 DT.120881867 DT.120881875 24/337 AceView cDNA sequences (see all 337): BG940403 CD171994 AI568236 BU679517 AW132016 AW293986 BG624070 AI590139 BX477927 BM821230 AI753960 AA135131 BU150219 BP342662 NM_198197 AI628586 BQ439096 AU280783 BI870434 AU134117 BP350183 BI093727 D81795 BE439902
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for UBA3 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UBA3
|
Expression
for UBA3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGTTTAAA
About this image
See UBA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBA3
SOURCE GeneReport for Unigene cluster: Hs.154320
UniProtKB/Swiss-Prot: UBA3_HUMAN, Q8TBC4Tissue specificity: Ubiquitously expressed
SABiosciences Expression via Pathway-Focused PCR Array including UBA3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBA3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBA3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBA3 |
Orthologs
for UBA3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBA3 gene from 8/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
UBA31 |
ubiquitin-like modifier activating enzyme 3 |
82.29(n)
90.28(a) |
|
426073 XM_003642026.1 XP_003642074.1 |
lizard
(Anolis carolinensis) |
Reptilia |
UBA36 |
-- |
89(a) |
1 ↔ 1 |
2(182340706-182359409) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.139602 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.54(n) |
|
CA792133.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.42242 |
Danio rerio mRNA similar to ubiquitin-activating enzyme more |
77.3(n) |
|
BC045372.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG133431 |
CG13343 |
59.76(n)
65.18(a) |
|
36539 NM_137069.3 NP_610913.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
rfl-11 |
Protein RFL-1 |
56.6(n)
55.07(a) |
|
175982 NM_066133.4 NP_498534.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ECR11 |
ubiquitin-activating enzyme E1 C |
54.06(n)
48.98(a) |
|
832038 NM_121923.3 NP_568370.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.101902 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.48(n) |
|
AK062561.1 |
ENSEMBL Gene Tree for UBA3 (if available)
TreeFam Gene Tree for UBA3 (if available) |
Paralogs
for UBA3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UBA3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBA3 (69103881 - 69129559 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UBA3
1 CNV: 51157
Human Gene Mutation Database (HGMD): UBA3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBA3 |
|
Disorders
/ Diseases
for UBA3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBA3 for disorders About GeneDecksing
OMIM gene information: 603172
OMIM disorders: --
2  diseases for UBA3: About MalaCardsmalaria neuronitis
Export disorders for UBA3 gene to outside databases
|
Publications
for UBA3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBA3 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with UBA3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A new NEDD8-ligating system for cullin-4A. (PubMed id 9694792)1, 2, 3 Osaka F.... Kato S. (1998)
- E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PubMed id 19250909)1, 2 Huang D.T....Schulman B.A. (2009)
- Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. (PubMed id 15694336)1, 2 Huang D.T....Schulman B.A. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. (PubMed id 15361859)1, 2 Huang D.T.... Schulman B.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. (PubMed id 12646924)1, 2 Walden H.... Schulman B.A. (2003)
- Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. (PubMed id 12740388)1, 2 Bohnsack R.N. and Haas A.L. (2003)
- The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. (PubMed id 14690597)1, 2 Walden H.... Schulman B.A. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
|
External Searches for UBA3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBA3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBA3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBA3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBA3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBA3 gene:
Search GeneIP for patents involving UBA3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for UBA3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UBA3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBA3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBA3 | | | OriGene Protein Over-expression Lysate for UBA3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBA3 | | OriGene 3'-UTR Clone for UBA3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBA3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBA3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UBA3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UBA3 | | OriGene Custom Protein Services for UBA3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBA3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBA3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBA3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBA3 |
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| | | | Search Tocris compounds for UBA3 |
| |  |  |  |  | | | | | | Recombinant Protein for UBA3 |
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 | | | UBA3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBA3 |
|  |  |  | | | | ThermoFisher Antibodies for UBA3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBA3 |
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