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UBA3 Gene

protein-coding GIFtS: 54

GC03M069187

ubiquitin-like modifier activating enzyme 3
(Previous names: ubiquitin-activating enzyme E1C (homologous to yeast UBA3), ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: UBE1C)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp566J164 ^²
EC 6.3.2.- ^³
MGC22384 ^²
UBE1C ^², ³
hUBA3 ^²
hUba3 ^¹

Descriptions
NEDD8-activating enzyme E1C ^³
Nedd8-activating enzyme hUba3 ^²
UBA3, ubiquitin-activating enzyme E1 homolog ^²
Ubiquitin-activating enzyme 3 ^², ³
Ubiquitin-activating enzyme E1C ^³
Ubiquitin-like modifier-activating enzyme 3 ^³
ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) ^¹, ²
ubiquitin-activating enzyme E1C (homologous to yeast UBA3) ^¹, ²
ubiquitin-like modifier activating enzyme 3 ^²

External Ids
HGNC: 12470¹
Entrez Gene: 9039²
UniProtKB: Q8TBC4³
Ensembl: ENSG00000144744⁷

Search outside databases for aliases for UBA3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBA3:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and

ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating

enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein

binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a

ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple

alternatively spliced transcript variants encoding distinct isoforms have been found for this

gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBA3_HUMAN, Q8TBC4

Function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first

adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side

chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally

transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity.

Necessary for cell cycle progression

Gene Wiki entry for UBA3 (UBE1C)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3-p13 Ensembl cytogenetic band: 3p14.1 HGNC cytogenetic band: 3p24.3-p13

UBA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M069187: (about GC identifiers)

Start:	69,186,571 bp from pter
End:	69,212,214 bp from pter
Size:	25,644 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022459.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBA3_HUMAN, Q8TBC4 (See protein sequence)

Recommended Name: NEDD8-activating enzyme E1 catalytic subunit

Size: 463 amino acids; 51852 Da

Subunit: Heterodimer of UBA3 and NAE1. Interacts with NEDD8, UBE2F and UBE2M. Binds ESR1 and ESR2

with bound steroid ligand (By similarity)

Miscellaneous: Arg-211 acts as a selectivity gate, preventing misactivation of ubiquitin by this

NEDD8-specific E1 complex

PDB structures from and Proteopedia :

1R4M (3D)

1R4N (3D)

1TT5 (3D)

1Y8X (3D)

1YOV (3D)

2NVU (3D)

3DBH (3D)

3DBL (3D)

3DBR (3D)

3FN1 (3D)

Secondary accessions: O76088 Q9NTU3

REFSEQ proteins (2 alternative transcripts):

NP_003959.3 NP_937838.1

ENSEMBL proteins:

ENSP00000354340 ENSP00000340041

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (UBE1C)
	Human Recombinant Proteins from Abnova (UBA3)

OriGene Purified Recombinant Human Proteins (see all 2): UBA3

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IDA	11256614

About this table

Antibodies for UBA3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UBA3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (UBE1C), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBA3)
	Novus Biologicals Antibody for UBA3

Assays for UBA3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8TBC4

ProtoNet protein and cluster: Q8TBC4

1 Blocks protein family: IPB000594 UBA/THIF-type NAD/FAD binding fold

UniProtKB/Swiss-Prot: UBA3_HUMAN, Q8TBC4

Similarity: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBA3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003968

Applied Biosystems Silencer® siRNAs for UBA3

Sigma-Aldrich siRNA and siRNA Panels for UBA3

Sigma-Aldrich shRNA Panels and shRNA for UBA3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBA3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_003968
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_003968
untagged cDNA clones in CMV expression vector (see all 3): NM_003968

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003968

UniProtKB/Swiss-Prot: UBA3_HUMAN, Q8TBC4

Function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first

adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side

chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally

transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity.

Necessary for cell cycle progression

Enzyme regulation: Binding of TP53BP2 to the regulatory subunit NAE1 decreases activity

Enzyme Number (IUBMB): EC 6.3.2.-

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Uba3):

cellular

embryogenesis

lethality-prenatal/perinatal

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	IPI	10722740 15361859
GO:0005524	ATP binding	IEA	--
GO:0008641	small protein activating enzyme activity	IEA	--
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: UBA3_HUMAN, Q8TBC4

Pathway: Protein modification; protein neddylation

Gene Network Central^TM Interacting Genes and Proteins Network for UBA3

5/18 Interacting proteins for UBA3 (Q8TBC4^{1, 2} ENSP00000354340³) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2M	P61081¹, ENSP00000253023³	EBI-717567, EBI-1041660 STRING (score=.999)
RAD23B	P54727²	MINT-2791310 MINT-2791370
CHD3	Q12873²	MINT-65033
RAD23A	P54725²	MINT-2791332
NAE1	ENSP00000290810³	STRING (score=.999)

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	protein modification process	TAS	9694792
GO:0006508	proteolysis	TAS	9694792
GO:0007049	cell cycle	IEA	--
GO:0008152	metabolic process	IEA	--
GO:0019941	modification-dependent protein catabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBA3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBA3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003968

Sigma-Aldrich siRNA and siRNA Panels for UBA3

Sigma-Aldrich shRNA Panels and shRNA for UBA3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003968 NM_198195

REFSEQ mRNAs for UBA3 gene (2 alternative transcripts):

NM_003968.3 NM_198195.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003968 NM_198195

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_003968
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_003968
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_003968

Additional cDNA sequence:

AB012190.1 AF046024.1 AK002159.1 AK289392.1 AK298878.1 AK314751.1 AK316540.1 AL117566.1

BC022853.1 CR533537.1 CR598743.1 CR606720.1

24/32 DOTS entries (see all 32 ):

DT.100824573 DT.95349004 DT.100824571 DT.452636 DT.120881860 DT.100673627 DT.120881849 DT.101984597

DT.120881856 DT.100824575 DT.99999886 DT.100674495 DT.100008710 DT.100036654 DT.120881863 DT.91759473

DT.91759480 DT.92001678 DT.100036656 DT.100824561 DT.100824563 DT.100824567 DT.120881875 DT.120881889

24/337 AceView cDNA sequences (see all 337 ):

BX327547 AI248702 BM725067 AW293986 BQ001860 CA419569 AA620323 AI628586

BU681516 AW132016 BM769632 BM830019 AW517668 CD514124 BU150219 CA445731

BE439902 CA776226 AA045168 CA406242 BU153416 AK002159 CN483729 AW467017

Unigene Cluster for UBA3:

Ubiquitin-like modifier activating enzyme 3

Hs.154320 [show with all ESTs]

Unigene Representative Sequence: NM_003968

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for UBA3 (see all 12 )

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17	^	18
SP1:													-																												-
SP2:													-
SP3:													-												-
SP4:													-
SP5:			-										-

About this scheme

ECgene alternative splicing isoforms for UBA3

2 Ensembl transcripts including schematic representations:

ENST00000361055 ENST00000349511

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBA3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBA3

¹ / ²

3 probe-sets matching UBA3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40066_at²	U95-A	1	1.00	1.00	1.00	1.00	--	--	--	--	--
209115_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
209115_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTGTTTAAA

SOURCE GeneReport for Unigene cluster: Hs.154320
UniProtKB/Swiss-Prot: UBA3_HUMAN, Q8TBC4
Tissue specificity: Ubiquitously expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBA3 gene from 5/23 species (see all 23 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBA3¹	--	ubiquitin-like modifier activating enzyme 3	95.68(n) 99.35(a)	476560 XM_859110.1 XP_864203.1
chimpanzee (Pan troglodytes)	UBA3¹	--	ubiquitin-like modifier activating enzyme 3	99.86(n) 100(a)	460496 XM_516573.2 XP_516573.2
cow (Bos taurus)	UBA3¹	--	ubiquitin-like modifier activating enzyme 3	95.61(n) 98.92(a)	512647 NM_001075574.1 NP_001069042.1
rat (Rattus norvegicus)	Uba3¹	--	ubiquitin-like modifier activating enzyme 3	92.35(n) 99.35(a)	117553 NM_057205.1 NP_476553.1
mouse (Mus musculus)	Uba3^{1, 5}	6⁵	ubiquitin-like modifier activating enzyme 3^{1, 5}	91.99(n)¹ 99.32(a)¹	22200¹ NM_011666.1¹ NP_035796.1¹ AA073106⁵ AA204189⁵ (see all 24)

About this table Species with no ortholog for UBA3

ENSEMBL Gene Tree for UBA3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBA3 gene

UBA2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/115 NCBI SNPs in UBA3 are shown (see all 115 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 60)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11709406^1,2	H	69186823(+)	`TAAATG/CAGTGT`	2	--	ut3¹		4	EU EA WA	420
--	rs11544137^1,2	H	69193951(-)	`TAAGGA/GTGTTG`	2	M/V	mis¹ ese³		4	EU EA WA	406
	rs13089408^1,2	H	69195304(+)	`CTTCTG/TGCGAT`	2	A/A	syn¹ ese³		4	EU EA WA	420
	rs2009602^1,2	A,C,F,H,O	69204331(+)	`TCTCAA/GTCTAT`	2	--	int¹		11	NA EA EU WA	1088
	rs2289245^1,2	A,C,F,H,O	69194739(+)	`ACAATT/CCTAAA`	2	--	int¹		8	EA NA EU WA	2036
	rs1866263^1,2	A,C,F,H,O	69188901(+)	`AAAACA/GTCTCT`	2	--	int¹		12	EA NA EU WA	1048
--	rs714300^1,2	A,C,F,O	69204533(+)	`GACCAC/TCTTGT`	2	--	int¹		11	NS MN EA NA	612
	rs3853157^1,2	A,C,F,H	69209318(+)	`CTATAC/TTCCTA`	2	--	int¹		11	EU EA WA NA	974
--	rs6766693^1,2	A,C,F,H	69202764(+)	`acaggC/Tgtaag`	2	--	int¹		3	EU EA	282
	rs3772979^1,2	A,C,F,H	69209823(+)	`AACTAT/CTATGG`	2	--	int¹		12	MN EU EA WA NA	1156

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HapMap Linkage Disequilibrium images for UBA3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603172

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/26 PubMed articles for UBA3 gene (see all 26 ):

A new NEDD8-ligating system for cullin-4A. (PubMed id 9694792)^{2, 3, 4} Osaka F.... Kato S. (1998)
Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. (PubMed id 15694336)^{3, 4} Huang D.T....Schulman B.A. (2005)
A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. (PubMed id 15361859)^{3, 4} Huang D.T.... Schulman B.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. (PubMed id 12740388)^{3, 4} Bohnsack R.N. and Haas A.L. (2003)
Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. (PubMed id 12646924)^{3, 4} Walden H.... Schulman B.A. (2003)
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. (PubMed id 14690597)^{3, 4} Walden H.... Schulman B.A. (2003)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{3, 4} Wiemann S.... Poustka A. (2001)
Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. (PubMed id 10207026)^{3, 4} Gong L. and Yeh E.T.H. (1999)
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PubMed id 19250909)⁴ Huang D.T....Schulman B.A. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9039	HGNC: 12470	AceView: UBE1C	Ensembl:ENSG00000144744	euGenes: HUgn9039
ECgene: UBA3	H-InvDB: UBA3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for UBA3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UBA3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBA3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBA3		Antibodies for UBA3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBA3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	shRNA in GFP-retroviral vector

Search Tocris compounds for UBA3

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UBA3 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
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Genomic Location
for UBA3

Proteins
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Genome Databases showing UBA3

Other Databases showing UBA3

Specialized Databases showing UBA3

Licensable Technologies
for UBA3

Services
for UBA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBA3 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor UBA3

Summariesfor UBA3

Genomic Locationfor UBA3

Proteinsfor UBA3

Protein Domains/Familiesfor UBA3

Gene Functionfor UBA3

Pathways & Interactionsfor UBA3

Drugs & Compoundsfor UBA3

Transcriptsfor UBA3

Expression for UBA3

Orthologsfor UBA3

Paralogsfor UBA3

SNPs/Variantsfor UBA3

Disorders & Mutationsfor UBA3

Medical Newsfor UBA3

Publicationsfor UBA3

Search for UBA3

Genome Databases showing UBA3

Other Databases showing UBA3

Specialized Databases showing UBA3

Licensable Technologiesfor UBA3

Servicesfor UBA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBA3

Summaries
for UBA3

Genomic Location
for UBA3

Proteins
for UBA3

Protein Domains/
Families
for UBA3

Gene Function
for UBA3

Pathways & Interactions
for UBA3

Drugs & Compounds
for UBA3

Transcripts
for UBA3

Expression
for UBA3

Orthologs
for UBA3

Paralogs
for UBA3

SNPs/Variants
for UBA3

Disorders & Mutations
for UBA3

Medical News
for UBA3

Publications
for UBA3

Licensable Technologies
for UBA3

Services
for UBA3