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Aliases & Descriptions for UBA2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ARX 1, 2 | | EC 6.3.2.- 3 | | FLJ13058 1, 2 | | HRIHFB2115 1, 2 | | SAE2 2, 3 | | UBLE1B 3 |
| | | Descriptions |
|---|
| Anthracycline-associated resistance ARX 3 | | SUMO-1 activating enzyme subunit 2 2 | | SUMO1 activating enzyme subunit 2 1, 2 | | UBA2, ubiquitin-activating enzyme E1 homolog 2 | | Ubiquitin-like 1-activating enzyme E1B 3 | | anthracycline-associated resistance 2 | | ubiquitin-like modifier activating enzyme 2 2 |
|
| | Search outside databases for aliases for UBA2 genePrevious GC identifers: GC19P035536 GC19P035368 GC19P039595 |
Summaries for UBA2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SAE2_HUMAN, Q9UBT2Function: The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2Gene Wiki entry for UBA2 (SAE2) |
Genomic Location for UBA2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the UBA2 gene 
Entrez Gene cytogenetic band: 19q12 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.11UBA2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P039611:
(about GC identifiers)
Start:
|
39,611,108 bp from pter |
End:
|
39,652,638 bp from pter |
Size:
|
41,531 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for UBA2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SAE2_HUMAN, Q9UBT2 (See
protein sequence)Recommended Name: SUMO-activating enzyme subunit 2 Size: 640 amino acids; 71224 Da
Subunit: Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2
Subcellular location: Nucleus
PDB structures from and Proteopedia :1Y8Q (3D)
 1Y8R (3D)
 2PX9 (3D)
 
Secondary accessions: O95605 Q59H87 Q6IBP6 Q9NTJ1 Q9UED2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005490.1
ENSEMBL proteins: ENSP00000246548
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for UBA2: Assays for UBA2: | Protein
Domains/ Families for UBA2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UBT2
ProtoNet protein and cluster: Q9UBT2 1 Blocks protein family: IPB000594 UBA/THIF-type NAD/FAD binding fold
UniProtKB/Swiss-Prot: SAE2_HUMAN, Q9UBT2Similarity: Belongs to the ubiquitin-activating E1 family | Gene Function for UBA2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005499
Applied Biosystems Silencer® siRNAs for UBA2
Sigma-Aldrich siRNA and siRNA Panels for UBA2  Sigma-Aldrich shRNA for UBA2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005499                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005499                                  untagged cDNA clone in CMV expression vector: NM_005499 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005499
UniProtKB/Swiss-Prot: SAE2_HUMAN, Q9UBT2Function: The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2Enzyme Number (IUBMB): EC 6.3.2.- Genatlas biochemistry entry for UBA2:sentrin (UBL1) avtivating protein component with AOS1(SAE1) and UBL1 required for activation of UBL11 MGI phenotypic allele for Uba2 (no phenotypes)
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for UBA2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: SAE2_HUMAN, Q9UBT2Pathway: Protein modification; protein sumoylation Gene Network CentralTM Interacting Genes and Proteins Network for UBA2 
5/16 Interacting proteins for UBA2 (ENSP000002465483 Q9UBT21, 2) via UniProtKB, MINT, and/or STRING (see all 16
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006464 | protein modification process |
IEA | -- | | GO:0019941 | modification-dependent protein catabolic process |
IEA | -- | About this table
|
Drugs & Compounds for UBA2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for UBA2
|
Transcripts for UBA2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005499
Sigma-Aldrich siRNA and siRNA Panels for UBA2  Sigma-Aldrich shRNA for UBA2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005499 REFSEQ mRNAs for UBA2 gene: NM_005499.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005499               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005499                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005499                                  untagged cDNA clone in CMV expression vector: NM_005499  Additional cDNA sequence: AB015337.1 AB208872.1 AF079566.1 AF090384.1 AF110957.1 AK023120.1 AK024114.1 AK124730.1 AK299514.1 AK315521.1 AL136905.1 BC003153.1 BT009781.1 CR456756.1 U35832.1 24/30 DOTS entries (see all 30
): DT.417687 DT.91769032 DT.95371608 DT.100827743 DT.100647308 DT.95371580 DT.101984590 DT.100827746 DT.121476967 DT.100838603 DT.100827747 DT.121476497 DT.40225546 DT.91769042 DT.100827744 DT.91877659 DT.95184015 DT.100827735 DT.100838962 DT.121398493 DT.121476622 DT.121476680 DT.121476978 DT.86855221 24/478 AceView cDNA sequences (see all 478
):BM702283 CB151012 BG257748 AW768255 BF436280 AF110957 BU145315 AA553714 BM806947 BF969748 CA393607 BQ213486 CB151240 AA693705 AW449744 BQ889474 AI862986 T16287 BE349506 BQ889284 AU124381 BM477166 BP338277 BM472688 Unigene Cluster for UBA2: Ubiquitin-like modifier activating enzyme 2 Hs.631580 [show with all ESTs]Unigene Representative Sequence: AK124730
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for UBA2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for UBA2
1 Ensembl transcript including schematic representation: ENST00000246548
|
Expression for UBA2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBA2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBA2
1 / 2 3 probe-sets matching UBA2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTGCCTTTTT
SOURCE GeneReport for Unigene cluster: Hs.631580
Expression variation in blood from EXPOLDB for UBA2 |
Orthologs for UBA2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBA2 gene from 5/24 species (see all 24
)
About this table Species with no ortholog for UBA2
ENSEMBL Gene Tree for UBA2 | Paralogs for UBA2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for UBA2 gene
- UBA32
|
SNPs/Variants for UBA2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for UBA2 (up to first 250kb)
|
Disorders & Mutations for UBA2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for UBA2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for UBA2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/24 PubMed articles for UBA2 gene (see all 24
):- Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. (PubMed id 10187858)1, 2, 3, 4 Desterro J.M.P.... Hay R.T. (1999)
- In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. (PubMed id 9920803)2, 3, 4 Okuma T....Yasuda H. (1999)
- Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. (PubMed id 10217437)1, 3, 4 Gong L....Yeh E.T. (1999)
- A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. (PubMed id 16620772)3, 4 Li T....Chock P.B. (2006)
- Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. (PubMed id 15660128)3, 4 Lois L.M. and Lima C.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. (PubMed id 11451954)3, 4 Tatham M.H.... Hay R.T. (2001)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3, 4 Wiemann S.... Poustka A. (2001)
- Expression and regulation of the mammalian SUMO-1 E1 enzyme. (PubMed id 11481243)3, 4 Azuma Y....Dasso M. (2001)
- Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)3, 4 Ueki N.... Muramatsu M.-A. (1998)
|
Search for UBA2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBA2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBA2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBA2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for UBA2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for UBA2:

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Incremental update: 13 Oct 2009
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