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UBA1 Gene

protein-coding GIFtS: 60

GC0XP046936

ubiquitin-like modifier activating enzyme 1
(Previous names: ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing), ubiquitin-activating enzyme E1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: A1S9T, GXP1, UBE1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
A1S9 ^²
A1S9T ^², ³
A1ST ^²
AMCX1 ^²
GXP1 ^²
MGC4781 ^²
OTTHUMP00000023197 ^²
OTTHUMP00000023198 ^²
SMAX2 ^²
UBA1A ^²
UBE1 ^², ³
UBE1X ^¹, ²

Descriptions
A1S9T and BN75 temperature sensitivity complementing ^²
Protein A1S9 ^³
UBA1, ubiquitin-activating enzyme E1 homolog A ^²
Ubiquitin-activating enzyme E1 ^¹, ², ³
ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing) ^¹
ubiquitin-like modifier activating enzyme 1 ^²

External Ids
HGNC: 12469¹
Entrez Gene: 7317²
UniProtKB: P22314³
Ensembl: ENSG00000130985⁷

Search outside databases for aliases for UBA1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBA1:

The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular

proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in

DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome

Xp11.23. Alternatively spliced transcript variants that encode the same protein have been

described. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBA1_HUMAN, P22314

Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and

thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an

ubiquitin-E1 thioester and free AMP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.3 HGNC cytogenetic band: Xp11.23

UBA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP046936: (about GC identifiers)

Start:	46,935,204 bp from pter
End:	46,959,471 bp from pter
Size:	24,268 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_079573.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBA1_HUMAN, P22314 (See protein sequence)

Recommended Name: Ubiquitin-like modifier-activating enzyme 1

Size: 1058 amino acids; 117849 Da

Subunit: Monomer (By similarity). Interacts with GAN (via BTB domain)

Miscellaneous: There are two active sites within the E1 molecule, allowing it to accommodate two

ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the

previous one is transferred to the thiol site

Secondary accessions: Q5JRR8 Q96E13

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_003325.2 NP_695012.1

ENSEMBL proteins:

ENSP00000338413 ENSP00000366481 ENSP00000366568 ENSP00000366483

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant UBA1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (E1 Ubiquitin Activating Enzyme)
	Human Recombinant Proteins from Abnova (UBA1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348

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Antibodies for UBA1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of UBA1
	Sigma-Aldrich Antibodies for UBA1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for UBA1 (UBE1)
	Antibodies from Abcam (E1 Ubiquitin Activating Enzyme), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBA1)
	Novus Biologicals Antibodies for UBA1

Assays for UBA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P22314

ProtoNet protein and cluster: P22314

2 Blocks protein families:

IPB000011 Ubiquitin-activating enzyme

IPB000594 UBA/THIF-type NAD/FAD binding fold

UniProtKB/Swiss-Prot: UBA1_HUMAN, P22314

Similarity: Belongs to the ubiquitin-activating E1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003334

Applied Biosystems Silencer® siRNAs for UBA1

Sigma-Aldrich siRNA and siRNA Panels for UBA1

Sigma-Aldrich shRNA Panels and shRNA for UBA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBA1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003334
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003334
untagged cDNA clones in CMV expression vector (see all 5): AF258566

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003334

UniProtKB/Swiss-Prot: UBA1_HUMAN, P22314

Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and

thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an

ubiquitin-E1 thioester and free AMP

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	IPI	16227972 17956732
GO:0005524	ATP binding	IEA	--
GO:0008641	small protein activating enzyme activity	IEA	--
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for UBA1 (Your Favorite Gene powered by Ingenuity)

Protein Ubiquitination Pathway

GeneDecks UBA1 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: UBA1_HUMAN, P22314

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for UBA1

5/39 Interacting proteins for UBA1 (P22314^{1, 2} ENSP00000338413³) via UniProtKB, MINT, and/or STRING (see all 39 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2I	P63279¹, ENSP00000348056³	EBI-709688, EBI-80168 STRING (score=.815)
GAN	Q9H2C0¹, ENSP00000248272³	EBI-709688, EBI-764342 STRING (score=.725)
HSP90AB1	P08238²	MINT-72666
TAF9	Q16594²	MINT-2863889
YWHAZ	P63104²	MINT-3318217

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	protein modification process	IEA	--
GO:0008152	metabolic process	IEA	--
GO:0019941	modification-dependent protein catabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBA1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003334

Sigma-Aldrich siRNA and siRNA Panels for UBA1

Sigma-Aldrich shRNA Panels and shRNA for UBA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003334 NM_153280

REFSEQ mRNAs for UBA1 gene (2 alternative transcripts):

NM_003334.3 NM_153280.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003334 NM_153280

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003334
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003334
                                 untagged cDNA clones in CMV expression vector (see all 5): AF258566

Additional cDNA sequence:

AK293161.1 AK296866.1 BC009900.2 BC013041.2 BC020261.1 CR594399.1 CR596473.1 CR600825.1

CR621823.1 M58028.1 X52897.1 X56976.1

24/54 DOTS entries (see all 54 ):

DT.91781965 DT.97775942 DT.450733 DT.95128992 DT.91781983 DT.97766500 DT.91786933 DT.100885038

DT.101970629 DT.100885069 DT.121314245 DT.91752333 DT.100885053 DT.95362864 DT.100885068 DT.75158289

DT.100885034 DT.100885065 DT.86853428 DT.100032930 DT.91781976 DT.91788914 DT.95128993 DT.100838668

24/826 AceView cDNA sequences (see all 826 ):

BX346007 F36171 F27144 CF121741 BU627536 BQ636342 BU069243 BQ071029

BE560798 BM708217 BU522072 CA442849 AA337777 AW502691 BC009900 BQ070361

CA306322 CR621823 BE546212 BM694877 AW880844 BG289248 BM756338 BM852847

Unigene Cluster for UBA1:

Ubiquitin-like modifier activating enzyme 1

Hs.533273 [show with all ESTs]

Unigene Representative Sequence: NM_003334

GeneLoc Exon Structure

5/30 Alternative Splicing Database (ASD) splice patterns (SP) for UBA1 (see all 30 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	·	10c	·	10d	^	11a	·	11b	^
SP1:																					-				-		-		-		-		-
SP2:																					-		-		-		-		-		-		-
SP3:																																	-
SP4:
SP5:																					-		-		-		-		-				-

ExUns:	12	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	^	16	^	17	^	18a	·	18b	·	18c	^	19a	·	19b	^	20a	·	20b	^	21a	·	21b	^	22a	·	22b	·	22c	^	23a	·	23b	^	24a	·	24b	^	25a	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	25b	·	25c	·	25d	^	26a	·	26b	·	26c	^	27a	·	27b	·	27c	^	28a	·	28b	·	28c	·	28d	^	29	^	30a	·	30b	·	30c	^	31a	·	31b	^	32	^	33a	·	33b
SP1:
SP2:
SP3:
SP4:																			-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for UBA1

4 Ensembl transcripts including schematic representations:

ENST00000335972 ENST00000377269 ENST00000377351 ENST00000377271

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBA1

¹ / ²

5 probe-sets matching UBA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1268_at²	U95-A	1	1.00	1.00	0.70	1.02	--	--	--	--	--
74862_at²	U95-D	1	0.38	1.00	0.94	0.98	--	--	--	--	--
200964_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
200964_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555387_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks UBA1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCAGCTGCCA

SOURCE GeneReport for Unigene cluster: Hs.533273

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBA1 gene from 5/25 species (see all 25 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBA1¹	--	ubiquitin-like modifier activating enzyme 1	90.88(n) 94.57(a)	480896 XM_538014.2 XP_538014.2
chimpanzee (Pan troglodytes)	UBA1¹	--	ubiquitin-like modifier activating enzyme 1	99.73(n) 99.59(a)	749307 XM_001167538.1 XP_001167538.1
cow (Bos taurus)	UBA1¹	--	ubiquitin-like modifier activating enzyme 1	91.43(n) 96.6(a)	282869 XM_001252171.1 XP_001252172.1
rat (Rattus norvegicus)	Uba1¹	--	ubiquitin-like modifier activating enzyme 1	89.35(n) 96.41(a)	314432 NM_001014080.1 NP_001014102.1
mouse (Mus musculus)	Uba1^{1, 5}	X (5.70 cM)⁵	ubiquitin-like modifier activating enzyme 1^{1, 5}	89.32(n)¹ 95.56(a)¹	22201¹ NM_009457.3¹ NP_033483.1¹ AA027544⁵ AA989744⁵ (see all 78)

About this table Species with no ortholog for UBA1

ENSEMBL Gene Tree for UBA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBA1 gene

UBA6² UBA7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/82 NCBI SNPs in UBA1 are shown (see all 82 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 36)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs2070169^1,2	C,F,H	46947478(+)	`TTAGCG/ACCAGA`	2	H/R	mis¹		9	MN NA EU EA WA	583
--	rs2230147^1,2	C,F,H	46955205(+)	`GCGCCA/GTTCTG`	2	P/P	syn¹		8	MN EU EA WA NA	620
	rs2228658^1,2	F	46955468(+)	`GTGGCC/TACATT`	2	A/A	syn¹ ese³		1	MN	62
	rs7877968^1,2	A,C,F,H	46947200(+)	`CAGGTT/GCCTCC`	2	--	int¹		4	EU EA WA	418
	rs5953008^1,2	A,C,F,H	46950533(+)	`GTGTCC/TGTCTT`	2	--	int¹		4	EU EA WA	412
	rs7891904^1,2	A,C,F,H	46942082(+)	`TGAAAC/TGTGAT`	2	--	int¹		6	EA WA NA	410
	rs4529579^1,2	A,C,F,H	46951274(+)	`ggatgC/Tcctgt`	2	--	int¹		11	EU EA WA NA	866
--	rs5953010^1,2	A,F,H	46950580(+)	`TTTGTG/CCTCCC`	2	--	int¹		4	EU EA WA	418
	rs6611347^1,2	C,F,H	46951299(+)	`ttctcA/Ggcatt`	2	--	int¹		8	EU EA WA	618
	rs12006836^1,2	C,F,H	46952355(+)	`taaagA/Gtgtta`	2	--	int¹		4	EU EA WA	406

About this table

HapMap Linkage Disequilibrium images for UBA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 314370

UniProtKB/Swiss-Prot: UBA1_HUMAN, P22314

Defects in UBA1 are the cause of spinal muscular atrophy X-linked type 2 (SMAX2)

[MIM:301830]; also known as X-linked lethal infantile spinal muscular atrophy, distal X-linked

arthrogryposis multiplex congenita or X-linked arthrogryposis type 1 (AMCX1). Spinal muscular

atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior

horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX2 is a

lethal infantile form presenting with hypotonia, areflexia, and multiple congenital contractures

GeneTests: UBA1

Spinal Muscular Atrophy

Human Gene Mutation Database: UBA1
Human Genome Epidemiology Navigator: UBA1 (0 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/56 PubMed articles for UBA1 gene (see all 56 ):

Rare missense and synonymous variants in UBE1 are associated with X- linked infantile spinal muscular atrophy. (PubMed id 18179898)^{3, 4} Ramser J.... Baumbach-Reardon L. (2008)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival. (PubMed id 16227972)^{3, 4} Allen E....Yang Y. (2005)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Complementation by a cloned human ubiquitin-activating enzyme E1 of the S-phase-arrested mouse FM3A cell mutant with thermolabile E1. (PubMed id 1606621)^{3, 4} Ayusawa D.... Seno T. (1992)
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1. (PubMed id 1871145)^{3, 4} (1991)
Human ubiquitin-activating enzyme (E1): compensation for heat-labile mouse E1 and its gene localization on the X chromosome. (PubMed id 1845793)^{2, 3} Kudo M....Ui M. (1991)
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1. (PubMed id 1986373)^{3, 4} Handley P.M.... Schwartz A.L. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7317	HGNC: 12469	AceView: UBE1	Ensembl:ENSG00000130985	euGenes: HUgn7317
ECgene: UBA1	H-InvDB: UBA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for UBA1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for UBA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBA1		Antibodies for UBA1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBA1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (UBA1)
	Antibodies (UBA1)
	Chimera RNAi (UBA1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for UBA1 (UBE1)

	Recombinant Proteins (E1 Ubiquitin Activating Enzyme)
	Antibodies (E1 Ubiquitin Activating Enzyme)

Search OriGene for UBA1

Search Tocris compounds for UBA1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for UBA1

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UBA1 Gene at Home site.
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UBA1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for UBA1

Summaries
for UBA1

Genomic Location
for UBA1

Proteins
for UBA1

Protein Domains/
Families
for UBA1

Gene Function
for UBA1

Pathways & Interactions
for UBA1

Drugs & Compounds
for UBA1

Transcripts
for UBA1

Expression
for UBA1

Orthologs
for UBA1

Paralogs
for UBA1

SNPs/Variants
for UBA1

Disorders & Mutations
for UBA1

Medical News
for UBA1

Publications
for UBA1

Search for UBA1

Genome Databases showing UBA1

Other Databases showing UBA1

Specialized Databases showing UBA1

Licensable Technologies
for UBA1

Services
for UBA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBA1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor UBA1

Summariesfor UBA1

Genomic Locationfor UBA1

Proteinsfor UBA1

Protein Domains/Familiesfor UBA1

Gene Functionfor UBA1

Pathways & Interactionsfor UBA1

Drugs & Compoundsfor UBA1

Transcriptsfor UBA1

Expression for UBA1

Orthologsfor UBA1

Paralogsfor UBA1

SNPs/Variantsfor UBA1

Disorders & Mutationsfor UBA1

Medical Newsfor UBA1

Publicationsfor UBA1

Search for UBA1

Genome Databases showing UBA1

Other Databases showing UBA1

Specialized Databases showing UBA1

Licensable Technologiesfor UBA1

Servicesfor UBA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBA1

Summaries
for UBA1

Genomic Location
for UBA1

Proteins
for UBA1

Protein Domains/
Families
for UBA1

Gene Function
for UBA1

Pathways & Interactions
for UBA1

Drugs & Compounds
for UBA1

Transcripts
for UBA1

Expression
for UBA1

Orthologs
for UBA1

Paralogs
for UBA1

SNPs/Variants
for UBA1

Disorders & Mutations
for UBA1

Medical News
for UBA1

Publications
for UBA1

Licensable Technologies
for UBA1

Services
for UBA1