UAP1L1 Gene
protein-coding GIFtS: 49
GCID: GC09P139971
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UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
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Aliases
for UAP1L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| UDP-N-Acteylglucosamine Pyrophosphorylase 1-Like 11 2 | | EC 2.7.78 | | RP11-229P13.182 | | EC 2.7.7.238 | | UDP-N-Acetylhexosamine Pyrophosphorylase-Like Protein 12 | | EC 2.7.7.278 | | EC 2.7.7.-3 | | |
Export aliases for UAP1L1 gene to outside databasesPrevious GC identifers: GC09P135329 GC09P137248 GC09P139091 GC09P109431 |
Summaries
for UAP1L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for UAP1L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_024000.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UAP1L1 gene promoter:
HOXA9B HOXA9 AhR RFX1 Pax-5 E47 Meis-1b HSF2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UAP1L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UAP1L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3UAP1L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P139971: view genomic region
(about GC identifiers)
Start:
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139,971,953 bp from pter |
End:
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139,978,991 bp from pter |
Size:
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7,039 bases |
Orientation:
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plus strand |
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Proteins
for UAP1L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UAP1L_HUMAN, Q3KQV9 (See
protein sequence)Recommended Name: UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 Size: 507 amino acids; 57030 Da
Sequence caution: Sequence=AAI06036.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=CAH10651.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW88343.1;Type=Erroneous gene model prediction;
Secondary accessions: A2AMJ8 Q5SPZ2 Q69YQ3 Q6ZR38Alternative splicing: 2 isoforms: Q3KQV9-1 Q3KQV9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UAP1L1: NX_Q3KQV9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q3KQV9
4/10 DME Specific Peptides for UAP1L1 (Q3KQV9) (see all 10)
UAP1L1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997192.2
ENSEMBL proteins: ENSP00000386935 ENSP00000353409
Human Recombinant Protein Products for UAP1L1:
UAP1L1 Antibody Products:
Assay Products for UAP1L1: |
Protein
Domains /
Families
for UAP1L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UAP1L1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q3KQV9ProtoNet protein and cluster: Q3KQV9 1 Blocks protein family: IPB002618 UTP--glucose-1-phosphate uridylyltransferase
UniProtKB/Swiss-Prot: UAP1L_HUMAN, Q3KQV9Similarity: Belongs to the UDPGP type 1 family |
Function
for UAP1L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Numbers (IUBMB): EC 2.7.7.272 EC 2.7.7.-1 EC 2.7.72 EC 2.7.7.232
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016779 | nucleotidyltransferase activity |
IEA | -- |
UAP1L1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for UAP1L1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UAP1L1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UAP1L1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UAP1L1 (NM_207309) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UAP1L1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UAP1L1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UAP1L1 |
|
Pathways & Interactions
for UAP1L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | UDP-N-acetyl-D-glucosamine biosynthesis II | | | 2 | Amino sugar and nucleotide sugar metabolism | | | 3 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for UAP1L1
2 
Kegg Pathways (Kegg details for UAP1L1):
UAP1L1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UAP1L1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for UAP1L1 (ENSP000003869354) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for UAP1L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UAP1L1
Search CenterWatch for drugs/clinical trials and news about UAP1L1 / UAP1L
|
Transcripts
for UAP1L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UAP1L1 gene: NM_207309.2 Unigene Cluster for UAP1L1: UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 Hs.142076 [show with all ESTs]Unigene Representative Sequence: NM_2073094 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409858(uc010ncb.3) ENST00000476184 ENST00000360271(uc004cla.4)
ENST00000474787
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UAP1L1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UAP1L1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UAP1L1 (NM_207309) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UAP1L1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UAP1L1 |
Additional cDNA sequence: AK022632.1 AK095393.1 BC010529.1 BC012838.1 BC041644.1 BC106035.1 BC136391.1 5 DOTS entries: DT.424855 DT.100834723 DT.433754 DT.100777744 DT.121200581 24/63 AceView cDNA sequences (see all 63): AI880199 BC012838 AL832421 NM_207309 BM129547 CK819561 BM272219 BQ063560 BG056072 BQ670945 C01904 AA179706 AK022632 BC041644 AK128529 BC010529 BQ232243 BQ437535 AI268812 AA316011 BQ880583 BI833135 BF933012 CK819560
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for UAP1L1 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UAP1L1
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Expression
for UAP1L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UAP1L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGGAACAG
About this image
See UAP1L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UAP1L1
SOURCE GeneReport for Unigene cluster: Hs.142076
SABiosciences Custom PCR Arrays for UAP1L1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UAP1L1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UAP1L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UAP1L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UAP1L1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UAP1L1 |
Orthologs
for UAP1L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UAP1L1 gene from 9/25 species (see all 25) About this table
ENSEMBL Gene Tree for UAP1L1 (if available)
TreeFam Gene Tree for UAP1L1 (if available) |
Paralogs
for UAP1L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UAP1L1 gene
- UAP12
1 SIMAP similar gene for UAP1L1 using alignment to 3 protein entries: UAP1L_HUMAN (see all proteins):UAP1
UAP1L1 for paralogs About GeneDecksing
|
Genomic Variants
for UAP1L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UAP1L1 (139971953 - 139978991 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for UAP1L1
2 CNVs: 4663 5415 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UAP1L1 |
|
Disorders
/ Diseases
for UAP1L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UAP1L1 for disorders About GeneDecksing
1  disease for UAP1L1: About MalaCardsmalaria
Export disorders for UAP1L1 gene to outside databases
|
Publications
for UAP1L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UAP1L1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with UAP1L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for UAP1L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UAP1L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UAP1L1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UAP1L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UAP1L1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UAP1L1 gene:
Search GeneIP for patents involving UAP1L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UAP1L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UAP1L1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UAP1L1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UAP1L1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UAP1L1 | | OriGene 3'-UTR Clone for UAP1L1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UAP1L1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UAP1L1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UAP1L1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UAP1L1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UAP1L1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UAP1L1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UAP1L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UAP1L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UAP1L1 |
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 | | | UAP1L1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UAP1L1 |
|  |  |  |  | | | | ThermoFisher Antibodies for UAP1L1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UAP1L1 |
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