Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UAP1 Gene

protein-coding   GIFtS: 65
GCID: GC01P162531

UDP-N-Acteylglucosamine Pyrophosphorylase 1


(Previous symbol: SPAG2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP-N-Acteylglucosamine Pyrophosphorylase 11 2     AGX22
SPAG21 2 3     Sperm Associated Antigen 22
Antigen X2 3     UDP-N-Acetylhexosamine Pyrophosphorylase2
Sperm-Associated Antigen 22 3     EC 2.7.78
AGX2 3     EC 2.7.7.238
AGX12     EC 2.7.7.278

External Ids:    HGNC: 124571   Entrez Gene: 66752   Ensembl: ENSG000001171437   OMIM: 6028625   UniProtKB: Q162223   

Export aliases for UAP1 gene to outside databases

Previous GC identifers: GC01P160166 GC01P158182 GC01P159227 GC01P159718 GC01P159262 GC01P160797 GC01P133776


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UAP1 Gene: 
UAP1 (UDP-N-acteylglucosamine pyrophosphorylase 1) is a protein-coding gene. Diseases associated with UAP1 include hepadnavirus infection, and hepatitis b virus infection, and among its related super-pathways are UDP-N-acetyl-D-glucosamine biosynthesis II and WNT ligand biogenesis and trafficking. GO annotations related to this gene include carbohydrate binding and UDP-N-acetylglucosamine diphosphorylase activity. An important paralog of this gene is UAP1L1.

UniProtKB/Swiss-Prot: UAP1_HUMAN, Q16222
Function: Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2
to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P

Gene Wiki entry for UAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UAP1 gene promoter:
         Sp1   AML1a   POU6F1 (c2)   POU2F1   POU2F1a   POU2F1b   POU2F1c   Pax-4a   ATF6   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.2

UAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UAP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P162531:  view genomic region     (about GC identifiers)

Start:
162,531,296 bp from pter      End:
162,569,633 bp from pter
Size:
38,338 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UAP1_HUMAN, Q16222 (See protein sequence)
Recommended Name: UDP-N-acetylhexosamine pyrophosphorylase  
Size: 522 amino acids; 58769 Da
Subunit: Monomer and homodimer. Isoform AGX1 is a homodimer. Isoform AGX2 is a monomer
Subcellular location: Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck
region of the head and to a lesser extent, the midpiece of the tail
4 PDB 3D structures from and Proteopedia for UAP1:
1JV1 (3D)        1JV3 (3D)        1JVD (3D)        1JVG (3D)    
Secondary accessions: B2R6R8 Q5VTA9 Q5VTB0 Q5VTB1 Q96GM2
Alternative splicing: 3 isoforms:  Q16222-1   Q16222-2   Q16222-3   

Explore the universe of human proteins at neXtProt for UAP1: NX_Q16222

Explore proteomics data for UAP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16222

  • 4/7 DME Specific Peptides for UAP1 (Q16222) (see all 7)
     YCVDNIL  EFSPLKN  VVEYSEIS  ADCGAKVV 

    UAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UAP1 Protein Expression
    REFSEQ proteins: NP_003106.3  
    ENSEMBL proteins: 
     ENSP00000395648   ENSP00000356903   ENSP00000356902   ENSP00000356901   ENSP00000271469  
    Reactome Protein details: Q16222
    Human Recombinant Protein Products for UAP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UAP1
    OriGene Protein Over-expression Lysate for UAP1
    OriGene MassSpec for UAP1 
    OriGene Custom Protein Services for UAP1
    GenScript Custom Purified and Recombinant Proteins Services for UAP1
    Novus Biologicals UAP1 Proteins
    Novus Biologicals UAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UAP1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    UAP1 for ontologies           About GeneDecksing



    UAP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UAP1
    OriGene Custom Antibody Services for UAP1
    GenScript Custom Superior Antibodies Services for UAP1
    Novus Biologicals UAP1 Antibodies
    Abcam antibodies for UAP1
    Cloud-Clone Corp. Antibodies for UAP1 
    ThermoFisher Antibody for UAP1
    LSBio Antibodies in human, mouse, rat for UAP1 

    Assay Products for UAP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UAP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UAP1 
    Cloud-Clone Corp. CLIAs for UAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002618 UDPGP_trans

    Graphical View of Domain Structure for InterPro Entry Q16222

    ProtoNet protein and cluster: Q16222

    1 Blocks protein domain: IPB002618 UTP--glucose-1-phosphate uridylyltransferase

    UniProtKB/Swiss-Prot: UAP1_HUMAN, Q16222
    Similarity: Belongs to the UDPGP type 1 family


    UAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UAP1_HUMAN, Q16222
    Function: Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2
    to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P
    Catalytic activity: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate +
    UDP-N-acetyl-alpha-D-galactosamine
    Catalytic activity: UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate +
    UDP-N-acetyl-alpha-D-glucosamine

         Enzyme Numbers (IUBMB): EC 2.7.7.272 EC 2.7.72 EC 2.7.7.232

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003977UDP-N-acetylglucosamine diphosphorylase activity TAS--
    GO:0016779nucleotidyltransferase activity ----
    GO:0030246carbohydrate binding IEA--
         
    UAP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UAP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UAP1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target UAP1:
    hsa-mir-30a (MIRT005200)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UAP1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate UAP1:
    hsa-miR-3163 hsa-miR-2115 hsa-miR-27a hsa-miR-624* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidUAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UAP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UAP1
    Sirion Biotech Customized adenovirus for overexpression of UAP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UAP1 (see all 7)
    OriGene ORF clones in mouse, rat for UAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UAP1 (NM_003115)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UAP1
    Sirion Biotech Customized lentivirus for stable overexpression of UAP1 
                         Customized lentivirus expression plasmids for stable overexpression of UAP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UAP1
    Search LifeMap BioReagents cell lines for UAP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UAP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UAP1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1UDP-N-acetyl-D-glucosamine biosynthesis II
    UDP-N-acetyl-D-glucosamine biosynthesis II0.67
    UDP-N-acetyl-D-galactosamine biosynthesis II0.30
    Synthesis of UDP-N-acetyl-glucosamine0.67
    2Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    Post-translational protein modification0.44
    WNT ligand biogenesis and trafficking0.77
    Metabolism of proteins0.35
    Signaling by Wnt0.62
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein0.53
    Synthesis of substrates in N-glycan biosythesis0.53
    4Signaling by GPCR
    Signal Transduction0.55
    5Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UAP1
        UDP-N-acetyl-D-glucosamine biosynthesis II
    UDP-N-acetyl-D-galactosamine biosynthesis II

    5/9        Reactome Pathways for UAP1 (see all 9)
        Signaling by Wnt
    Asparagine N-linked glycosylation
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Synthesis of substrates in N-glycan biosythesis
    Signal Transduction


    2         Kegg Pathways  (Kegg details for UAP1):
        Amino sugar and nucleotide sugar metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: UAP1_HUMAN, Q16222
    Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis;
    UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1


    UAP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/21 Interacting proteins for UAP1 (Q162223 ENSP000003569034) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CTHP329293I2D: score=1 
    GCSHP234343I2D: score=1 
    GGPS1O957493I2D: score=1 
    IQGAP2Q135763I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006047UDP-N-acetylglucosamine metabolic process ----
    GO:0006048UDP-N-acetylglucosamine biosynthetic process TAS--
    GO:0006488dolichol-linked oligosaccharide biosynthetic process TAS--
    GO:0008152metabolic process ----
    GO:0018279protein N-linked glycosylation via asparagine TAS--

    UAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UAP1

    6 HMDB Compounds for UAP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glucosamine-1Palpha-D-glucosamine 1-phosphate (see all 5)----
    N-Acetyl-glucosamine 1-phosphateD-glucosamine 1-phosphate (see all 9)901851-43-2--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--
    Uridine triphosphate5'-UTP (see all 7)63-39-8--

    2 DrugBank Compounds for UAP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Uridine-Diphosphate-N-Acetylgalactosamine-- --target--17139284 17016423
    Uridine-Diphosphate-N-Acetylglucosamine-- --target--17139284 17016423

    3 Novoseek inferred chemical compound relationships for UAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udp-n-acetylglucosamine 89.6 29 10799561 (5), 9603950 (3), 1484552 (1), 15803415 (1) (see all 10)
    glucosamine 6-phosphate 69.1 1 10799561 (1)
    chitin 39.3 1 16368930 (1)

    Search CenterWatch for drugs/clinical trials and news about UAP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UAP1 gene: 
    NM_003115.4  

    Unigene Cluster for UAP1:

    UDP-N-acteylglucosamine pyrophosphorylase 1
    Hs.492859  [show with all ESTs]
    Unigene Representative Sequence: NM_003115
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412525 ENST00000367926(uc001gce.4) ENST00000476240 ENST00000367925
    ENST00000367924 ENST00000474728 ENST00000486089 ENST00000271469
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UAP1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate UAP1:
    hsa-miR-3163 hsa-miR-2115 hsa-miR-27a hsa-miR-624* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidUAP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UAP1
    Clone
    Products:
         
    OriGene clones in human, mouse for UAP1 (see all 7)
    OriGene ORF clones in mouse, rat for UAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UAP1 (NM_003115)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UAP1
    Sirion Biotech Customized lentivirus for stable overexpression of UAP1 
                         Customized lentivirus expression plasmids for stable overexpression of UAP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for UAP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UAP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UAP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UAP1

    Additional mRNA sequence: 

    AB011004.1 AK312685.1 BC009377.2 S73498.1 

    15 DOTS entries:

    DT.443886  DT.95145449  DT.100795034  DT.92030233  DT.100795035  DT.121390409  DT.91734525  DT.92450348 
    DT.100795030  DT.100795033  DT.120969840  DT.206569  DT.65286153  DT.95145462  DT.40111992 

    24/264 AceView cDNA sequences (see all 264):

    CB129809 CB132463 BI857964 AW073997 CB129958 AL576735 BU508403 BI868453 
    BQ929867 BM828651 NM_003115 BQ774634 BU166439 BE925981 CD558935 BU506926 
    BM461698 AW136085 CA446995 AI989289 BC009377 BM804379 BU154308 BG250556 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for UAP1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
    SP1:              -     -     -                                                                             -                 -     -                           
    SP2:                                                                                                        -                       -                           
    SP3:                                                                                                        -                       -                           
    SP4:                                                                                                        -                                                   
    SP5:                    -                                                                                                                                       


    ECgene alternative splicing isoforms for UAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UAP1 expression in normal human tissues (normalized intensities)      UAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAAGGTT
    UAP1 Expression
    About this image


    UAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Intestine (Gastrointestinal Tract)
             ileum   
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   
     
     Colon (Gastrointestinal Tract)

    See UAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UAP1

    SOURCE GeneReport for Unigene cluster: Hs.492859

    UniProtKB/Swiss-Prot: UAP1_HUMAN, Q16222
    Tissue specificity: Widely expressed. Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform
    AGX2 is more abundant than isoform AGX1 in somatic tissue. Expressed at low level in placenta, muscle and liver

        SABiosciences Custom PCR Arrays for UAP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for UAP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UAP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UAP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UAP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UAP1 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uap11 , 5 UDP-N-acetylglucosamine pyrophosphorylase 11, 5 88.65(n)1
    93.47(a)1
      1 (76.84 cM)5
    1076521  NM_133806.41  NP_598567.21 
     1701419385 
    chicken
    (Gallus gallus)
    Aves UAP11 UDP-N-acteylglucosamine pyrophosphorylase 1 70.38(n)
    80.45(a)
      424368  XM_003641671.1  XP_003641719.1 
    lizard
    (Anolis carolinensis)
    Reptilia UAP16
    Uncharacterized protein
    77(a)
    1 ↔ 1
    GL343300.1(1138794-1167303)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55562 Xenopus laevis transcribed sequence with moderate similarity more 77.69(n)    CA972646.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.37732 Danio rerio mRNA similar to expressed sequence AA42 more 75.92(n)    BC044137.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD246393
    mmy1
    UDP-N-acetylglucosamine
    pyrophosphorylase3
    mummy1
    51(a)3
    56.68(n)1
    54.53(a)1
      26D73
    339031  NM_135188.21  NP_609032.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K06B9.23   -- 43(a)
    (best of 2)
      IV(4194487-4196092)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes QRI1(YDL103C)4
    QRI11
    UDP-N-acetylglucosamine pyrophosphorylase, catalyzes more4
    Qri1p1
    50.18(n)1
    42.64(a)1
      4(276581-275148)4
    8514551, 4  NP_010180.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GlcNA.1UT21 putative UDP-N-acetylglucosamine pyrophosphorylase 52.65(n)
    45.41(a)
      818066  NM_129054.3  NP_181047.1 
    rice
    (Oryza sativa)
    Liliopsida AK071409.12   -- 73.5(n)    AK071409.1 


    ENSEMBL Gene Tree for UAP1 (if available)
    TreeFam Gene Tree for UAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UAP1 gene
    UAP1L12  
    1 SIMAP similar gene for UAP1 using alignment to 2 protein entries:     UAP1_HUMAN (see all proteins):
    UAP1L1

    UAP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UAP1
    PGOHUM00000237424


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/827 SNPs in UAP1 are shown (see all 827)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120457601,2
    C,Funtested1162566561(+) ACTACA/C/GTACTT 1 -- int15NA EA 246
    rs779446101,2
    C,F--162529489(+) TTCGAA/CGGACA 1 -- us2k12Minor allele frequency- C:0.13WA NA 238
    rs1865856691,2
    --162529503(+) ATAACA/TCTAGT 1 -- us2k10--------
    rs602589331,2
    C--162529511(+) GTGTT-/AAGACA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1384100511,2
    --162529563(+) TTATGA/CCTAGT 1 -- us2k10--------
    rs1492418361,2
    C--162529665(+) CCTCAG/TTTCTA 1 -- us2k10--------
    rs1889842731,2
    C--162529917(+) TCCTAA/GTTTGA 1 -- us2k10--------
    rs1446488861,2
    --162529927(+) AATTAA/TTAAGT 1 -- us2k10--------
    rs1393580771,2
    --162530000(+) ATCGAC/TTGGTT 1 -- us2k10--------
    rs1817075651,2
    --162530017(+) AACCAC/TCAAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UAP1 (162531296 - 162569633 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UAP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv516482CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for UAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602862    OMIM disorders: --

    16 diseases for UAP1:    About MalaCards
    hepadnavirus infection    hepatitis b virus infection    hepatitis b    esophageal squamous cell carcinoma
    essential hypertension    intrahepatic cholangiocarcinoma    hepatitis    cholangiocarcinoma
    infertility    hepatocellular carcinoma    hypertension    esophagitis
    squamous cell carcinoma    colorectal cancer    lung cancer    endotheliitis


    UAP1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for UAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis b 54.1 16 2311861 (3), 2353461 (2), 1955710 (2), 7658063 (1) (see all 8)
    hepatocellular carcinoma 25.4 2 10208429 (2)
    hepatitis 21.8 2 2365196 (1), 2311861 (1)
    cancer 0 2 17305540 (1), 10449611 (1)

    Genetic Association Database (GAD): UAP1
    Human Genome Epidemiology (HuGE) Navigator: UAP1 (1 document)

    Export disorders for UAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UAP1 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with UAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human antigen with sera from infertile patients. (PubMed id 8025165)1, 2, 3, 9 Diekman A.B. and Goldberg E. (1994)
    2. The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases: gene cloning, protein expression, and catalytic mechanism. (PubMed id 9603950)1, 2, 3, 9 Mio T.... Yamada-Okabe H. (1998)
    3. A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc. (PubMed id 9765219)1, 2, 9 Wang-Gillam A.... Elbein A.D. (1998)
    4. Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture. (PubMed id 11707391)1, 2, 9 Peneff C.... Bourne Y. (2001)
    5. Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (2009)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa. (PubMed id 9621304)1, 9 Diekman A.B....Goldberg E. (1998)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6675 HGNC: 12457 AceView: UAP1 Ensembl:ENSG00000117143 euGenes: HUgn6675
    ECgene: UAP1 Kegg: 6675 H-InvDB: UAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UAP1 gene:
    Search GeneIP for patents involving UAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UAP1   OriGene RNAi products in human, mouse, rat for UAP1  
     OriGene qPCR primer pairs and template standards for UAP1   OriGene Protein Over-expression Lysate for UAP1  
     OriGene MassSpec something-or-other for UAP1   OriGene clones in human, mouse for UAP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for UAP1   OriGene Purified Protein for UAP1  
     OriGene ORF clones in mouse, rat for UAP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UAP1   OriGene Custom Protein Services for UAP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UAP1
     QIAGEN SeqTarget long-range PCR primers for resequencing UAP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UAP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UAP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UAP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UAP1
     GenScript Custom Purified and Recombinant Proteins Services for UAP1 GenScript cDNA clones with any tag delivered in your preferred vector for UAP1
     GenScript Custom Assay Services for UAP1 GenScript Custom Superior Antibodies Services for UAP1
     GenScript Custom overexpressing Cell Line Services for UAP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UAP1 promoter
     Search Chromatin IP Primers for UAP1
     RT2 qPCR Primer Assay in human, mouse, rat UAP1
     Search GNC Networks for UAP1
     SABiosciences Custom PCR Arrays for UAP1
     Search Tocris compounds for UAP1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UAP1 antibodies
     UAP1 proteins
     UAP1 lysates
     Antibodies for UAP1
     See all of Abcam's Antibodies, Kits and Proteins for UAP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for UAP1
     Antibodies for UAP1
     ELISAs for UAP1
     CLIAs for UAP1
     Search LifeMap BioReagents cell lines for UAP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UAP1
     SwitchGear 3'UTR luciferase reporter plasmids for UAP1
     SwitchGear Promoter luciferase reporter plasmids for UAP1
     ThermoFisher Antibody for UAP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UAP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UAP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UAP1
    Customized:
     lentivirus for stable overexpression of UAP1
     lentivirus expression plasmids for stable overexpression of UAP1
     adenovirus for overexpression of UAP1
     LSBio Antibodies in human, mouse, rat for UAP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UAP1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4