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UAP1 Gene

protein-coding GIFtS: 59

GC01P160797

UDP-N-acteylglucosamine pyrophosphorylase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SPAG2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AGX ^², ³
AGX1 ^¹, ²
AGX2 ^²
AgX ^¹
OTTHUMP00000032325 ^²
SPAG2 ^², ³

Descriptions
Antigen X ^², ³
Sperm-associated antigen 2 ^³
UDP-N-acetylglucosamine pyrophosphorylase 1 ^²
UDP-N-acetylhexosamine pyrophosphorylase ^²
UDP-N-acteylglucosamine pyrophosphorylase 1 ^²
sperm associated antigen 2 ^²

External Ids
HGNC: 12457¹
Entrez Gene: 6675²
UniProtKB: Q16222³
Ensembl: ENSG00000117143⁷

Search outside databases for aliases for UAP1 gene

Previous GC identifers: GC01P160166 GC01P158182 GC01P159227 GC01P159718 GC01P159262

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: UAP1_HUMAN, Q16222

Function: Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc.

Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times

more activity towards GlcNAc-1-P

Gene Wiki entry for UAP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UAP1 gene

Entrez Gene cytogenetic band: 1q23.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23.2

UAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P160797: (about GC identifiers)

Start:	160,797,920 bp from pter
End:	160,836,257 bp from pter
Size:	38,338 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UAP1_HUMAN, Q16222 (See protein sequence)

Recommended Name: UDP-N-acetylhexosamine pyrophosphorylase

Size: 522 amino acids; 58769 Da

Subunit: Monomer and homodimer. Isoform AGX1 is a homodimer. Isoform AGX2 is a monomer

Subcellular location: Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail,

the neck region of the head and to a lesser extent, the midpiece of the tail

PDB structures from and Proteopedia :

1JV1 (3D)

1JV3 (3D)

1JVD (3D)

1JVG (3D)

Secondary accessions: Q5VTA9 Q5VTB0 Q5VTB1 Q96GM2

Alternative splicing: 3 isoforms: Q16222-1 Q16222-2 Q16222-3

REFSEQ proteins: NP_003106.3

ENSEMBL proteins:

ENSP00000271469 ENSP00000356903 ENSP00000356902 ENSP00000356901

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (UAP1)
	Human Recombinant Proteins from Abnova (UAP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for UAP1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UAP1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (UAP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UAP1)
	Novus Biologicals Antibodies for UAP1

Assays for UAP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q16222

ProtoNet protein and cluster: Q16222

1 Blocks protein family: IPB002618 UTP--glucose-1-phosphate uridylyltransferase

UniProtKB/Swiss-Prot: UAP1_HUMAN, Q16222

Similarity: Belongs to the UDPGP type 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UAP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UAP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003115

Applied Biosystems Silencer® siRNAs for UAP1

Sigma-Aldrich siRNA for UAP1

Sigma-Aldrich shRNA for UAP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UAP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003115
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003115
untagged cDNA clone in CMV expression vector: NM_003115

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003115

UniProtKB/Swiss-Prot: UAP1_HUMAN, Q16222

Function: Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc.

Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times

more activity towards GlcNAc-1-P

Catalytic activity: UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate +

UDP-N-acetyl-D-glucosamine

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	TAS	9603950
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for UAP1 (Your Favorite Gene powered by Ingenuity)

Aminosugars Metabolism

GeneDecks UAP1 for the pathways selected above

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UniProtKB/Swiss-Prot: UAP1_HUMAN, Q16222

Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-D-glucosamine biosynthesis;

UDP-N-acetyl-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1

5 Interacting proteins for UAP1 (ENSP00000356902³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PGM3	ENSP00000283977³	STRING (score=.952)
GALE	ENSP00000363621³	STRING (score=.899)
GNE	ENSP00000340770³	STRING (score=.899)
MLXIPL	ENSP00000320886³	STRING (score=.749)
SPAG17	ENSP00000337804³	STRING (score=.724)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	TAS	9603950
GO:0008152	metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UAP1
3 Novoseek chemical compound relationships for UAP1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
udp-n-acetylglucosamine	90.15	29	10799561 (5), 9603950 (3), 1484552 (1), 15803415 (1) (see all 10)
glucosamine 6-phosphate	70.11	1	10799561 (1)
chitin	41.26	1	16368930 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UAP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UAP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003115

Sigma-Aldrich siRNA for UAP1

Sigma-Aldrich shRNA for UAP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003115

REFSEQ mRNAs for UAP1 gene:

NM_003115.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003115

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003115
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003115
                                 untagged cDNA clone in CMV expression vector: NM_003115

Additional cDNA sequence:

AB011004.1 AK312685.1 BC009377.2 S73498.1

15 DOTS entries:

DT.443886 DT.95145449 DT.100795034 DT.92030233 DT.92450348 DT.121390409 DT.91734525 DT.95145462

DT.100795030 DT.100795033 DT.100795035 DT.120969840 DT.206569 DT.40111992 DT.65286153

24/264 AceView cDNA sequences (see all 264 ):

BU161080 CB125476 CB129809 BQ774634 AL045213 BM785654 BM461698 BU508403

AW827133 BU154308 BE883933 AB011004 BU166439 BC009377 AL576735 AI373868

CN482165 AW136085 AI765598 BP346402 BQ774669 BM450979 NM_003115 AI989289

highest scoring ESTs for UAP1:

AB011004 AA115451 AA448531 AA551705 AA720527 AA876680 AA934547 AI598039 AI608944 AI674137

Unigene Cluster for UAP1:

UDP-N-acteylglucosamine pyrophosphorylase 1

Hs.492859 [show with all ESTs]

Unigene Representative Sequence: NM_003115

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for UAP1 (see all 9 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	·	13c
SP1:					-		-		-																										-						-		-
SP2:																																			-								-
SP3:																																			-								-
SP4:																																			-
SP5:							-

About this scheme

ECgene alternative splicing isoforms for UAP1

4 Ensembl transcripts including schematic representations:

ENST00000271469 ENST00000367926 ENST00000367925 ENST00000367924

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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UAP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UAP1

¹ / ² / ³

3 probe-sets matching UAP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41242_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB011004	1.00	1.00	1.00	1
209340_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S73498	0.80	1.00	0.91	1
209340_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks UAP1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGAAAGGTT

SOURCE GeneReport for Unigene cluster: Hs.492859
Expression variation in blood from EXPOLDB for UAP1
UniProtKB/Swiss-Prot: UAP1_HUMAN, Q16222
Tissue specificity: Widely expressed. Isoform AGX1 is more abundant in testis than isoform AGX2,
while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Expressed at low level in
placenta, muscle and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UAP1 gene from 5/20 species (see all 20 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UAP1¹	--	UDP-N-acteylglucosamine pyrophosphorylase 1	92.54(n) 96.24(a)	488664 XM_545781.2 XP_545781.2
chimpanzee (Pan troglodytes)	UAP1¹	--	UDP-N-acteylglucosamine pyrophosphorylase 1	99.67(n) 99.8(a)	457466 XM_001174283.1 XP_001174283.1
cow (Bos taurus)	UAP1¹	--	UDP-N-acteylglucosamine pyrophosphorylase 1	93.6(n) 96.04(a)	535325 NM_001046404.1 NP_001039869.1
rat (Rattus norvegicus)	Uap1¹	--	UDP-N-acteylglucosamine pyrophosphorylase 1	87(n) 93.27(a)	498272 XM_573497.2 XP_573497.1
mouse (Mus musculus)	Uap1^{1, 5}	1⁵	UDP-N-acetylglucosamine pyrophosphorylase 1^{1, 5}	88.58(n)¹ 93.47(a)¹	107652¹ NM_133806.3¹ NP_598567.2¹ AA420407⁵ AA437972⁵ (see all 27)

About this table Species with no ortholog for UAP1

ENSEMBL Gene Tree for UAP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UAP1 gene

UAP1L1²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/190 NCBI SNPs in UAP1 are shown (see all 190 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 70)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1128539^1,2	C,F,H	160826820(+)	`CAACCC/ATACTA`	1	H/P	mis¹ ese³		9	MN EU EA WA	1018
	rs12091021^1,2	C,F,H	160835694(+)	`TAGAAA/GGTTAT`	1	S/G	mis¹		9	EU EA WA NA	856
	rs6663778^1,2	F,H	160797220(+)	`TCCTCC/TACCAT`	1	--	ng5¹		3	EU EA	296
--	rs11553690^1,2	C,H	160802597(+)	`TCCAGG/ACCATG`	1	T/A	mis¹ ese³		8	EU EA WA	804
	rs11589031^1,2	H	160836188(+)	`TTATCA/CAACAT`	1	--	ut3¹		4	EU EA WA	420
	rs28384482^1,2	F	160797528(+)	`CCGCCC/TTTTCC`	1	--	ng5¹		2	MN EA	1252
	rs1510267^1,2	A,C,F,H,O	160829399(+)	`AATGGG/AGAGCA`	1	--	int¹		11	NA EA MN EU WA	1007
	rs12130399^1,2	A,C,F,H	160809796(+)	`GCGAGA/GCTCTT`	1	--	int¹		4	EU EA WA	418
	rs1039869^1,2	A,C,F,H	160812415(-)	`gctacA/Gtgagt`	1	--	int¹		3	EU EA	260
	rs6695928^1,2	A,C,F,H	160802130(+)	`CTCACT/CGGTTA`	1	--	int¹		8	EU EA WA	838

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HapMap Linkage Disequilibrium images for UAP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602862

UniProtKB/Swiss-Prot: UAP1_HUMAN, Q16222

Antigen implicated in antibody-mediated male infertility

4 Novoseek disease relationships for UAP1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis b	55.58	16	2311861 (3), 2353461 (2), 1955710 (2), 7658063 (1) (see all 8)
hepatocellular carcinoma	27.58	2	10208429 (2)
hepatitis	23.44	2	2365196 (1), 2311861 (1)
cancer	0.00	2	17305540 (1), 10449611 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/38 PubMed articles for UAP1 gene (see all 38 ):

Characterization of a human antigen with sera from infertile patients. (PubMed id 8025165)^{1, 2, 3, 4} Diekman A.B. and Goldberg E. (1994)
The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases: gene cloning, protein expression, and catalytic mechanism. (PubMed id 9603950)^{1, 2, 3, 4} Mio T.... Yamada-Okabe H. (1998)
A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc. (PubMed id 9765219)^{1, 3, 4} Wang-Gillam A.... Elbein A.D. (1998)
Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture. (PubMed id 11707391)^{1, 3, 4} Peneff C.... Bourne Y. (2001)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa. (PubMed id 9621304)^{1, 3} Diekman A.B....Goldberg E. (1998)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
UDP-N-acetylglucosamine pyrophosphorylase, a key enzyme in encysting Giardia, is allosterically regulated. (PubMed id 10799561)¹ Bulik D.A....Jarroll E.L. (2000)
X antigen/antibody markers in hepadnavirus infections. Presence and significance of hepadnavirus X gene product(s) in serum. (PubMed id 2311861)¹ Feitelson M.A....Blumberg B.S. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6675	HGNC: 12457	AceView: UAP1	Ensembl:ENSG00000117143	euGenes: HUgn6675
ECgene: UAP1	H-InvDB: UAP1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for UAP1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UAP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UAP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UAP1		Antibodies for UAP1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UAP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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UAP1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for UAP1

Summaries
for UAP1

Genomic Location
for UAP1

Proteins
for UAP1

Protein Domains/
Families
for UAP1

Gene Function
for UAP1

Pathways & Interactions
for UAP1

Drugs & Compounds
for UAP1

Transcripts
for UAP1

Expression
for UAP1

Orthologs
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Disorders & Mutations
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Services
for UAP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UAP1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor UAP1

Summariesfor UAP1

Genomic Locationfor UAP1

Proteinsfor UAP1

Protein Domains/Familiesfor UAP1

Gene Functionfor UAP1

Pathways & Interactionsfor UAP1

Drugs & Compoundsfor UAP1

Transcriptsfor UAP1

Expression for UAP1

Orthologsfor UAP1

Paralogsfor UAP1

SNPs/Variantsfor UAP1

Disorders & Mutationsfor UAP1

Medical Newsfor UAP1

Publicationsfor UAP1

Search for UAP1

Genome Databases showing UAP1

Other Databases showing UAP1

Specialized Databases showing UAP1

Licensable Technologiesfor UAP1

Servicesfor UAP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UAP1

Summaries
for UAP1

Genomic Location
for UAP1

Proteins
for UAP1

Protein Domains/
Families
for UAP1

Gene Function
for UAP1

Pathways & Interactions
for UAP1

Drugs & Compounds
for UAP1

Transcripts
for UAP1

Expression
for UAP1

Orthologs
for UAP1

Paralogs
for UAP1

SNPs/Variants
for UAP1

Disorders & Mutations
for UAP1

Medical News
for UAP1

Publications
for UAP1

Licensable Technologies
for UAP1

Services
for UAP1