Aliases for UACA Gene
External Ids for UACA Gene
Previous GeneCards Identifiers for UACA Gene
GeneCards Summary for UACA Gene
UACA (Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats) is a Protein Coding gene. Diseases associated with UACA include Panuveitis and Behcet's Disease. An important paralog of this gene is ANKRD24.
UniProtKB/Swiss-Prot for UACA Gene
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).
Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity).