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U2SURP Gene

protein-coding   GIFtS: 50
GCID: GC03P142683

U2 SnRNP-Associated SURP Domain Containing

  Search for U2SURP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
U2 SnRNP-Associated SURP Domain Containing1 2     Ser/Arg-Rich Domain Protein1
Functional Spliceosome-Associated Protein A1 2     fSAPa2
U2 Associated SR140 Protein1 2     Ser/Arg-Rich Domain Protein, 140 KDa2
140 KDa Ser/Arg-Rich Domain Protein2 3     U2 SnRNP-Associated SURP Motif-Containing Protein2
SR1402 3     U2-Associated SR140 Protein2
U2-Associated Protein SR1402 3     KIAA03323
140 KDa1     

External Ids:    HGNC: 308551   Entrez Gene: 233502   Ensembl: ENSG000001637147   UniProtKB: O150423   

Export aliases for U2SURP gene to outside databases

Previous GC identifer: GC03P142720


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for U2SURP Gene:
U2SURP (U2 snRNP-associated SURP domain containing) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for U2SURP
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for U2SURP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat U2SURP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

U2SURP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
U2SURP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P142683:  view genomic region     (about GC identifiers)

Start:
142,683,339 bp from pter      End:
142,779,567 bp from pter
Size:
96,229 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SR140_HUMAN, O15042 (See protein sequence)
Recommended Name: U2 snRNP-associated SURP motif-containing protein  
Size: 1029 amino acids; 118292 Da
Subunit: Interacts with ERBB4
Sequence caution: Sequence=AAH16323.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAI05605.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: A0PJ60 Q0D2M1 Q2NKQ7 Q9BR70
Alternative splicing: 3 isoforms:  O15042-1   O15042-2   O15042-3   

Explore the universe of human proteins at neXtProt for U2SURP: NX_O15042

Explore proteomics data for U2SURP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys476, Lys488, Lys541, Lys622
  • Modification sites at PhosphoSitePlus

  • See U2SURP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073884.1  
    ENSEMBL proteins: 
     ENSP00000475195   ENSP00000430816   ENSP00000418465   ENSP00000418563   ENSP00000422011  
     ENSP00000420210   ENSP00000420575   ENSP00000417831   ENSP00000417441   ENSP00000418220  
     ENSP00000381027  

    U2SURP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for U2SURP
    OriGene Custom MassSpec
    OriGene Custom Protein Services for U2SURP
    GenScript Custom Purified and Recombinant Proteins Services for U2SURP
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for U2SURP

     
    Search eBioscience for Proteins for U2SURP 

    U2SURP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for U2SURP
    Novus Biologicals U2SURP Antibodies
    Search for Antibodies for U2SURP at Abcam
    Cloud-Clone Corp. Antibodies for U2SURP
    Search ThermoFisher Antibodies for U2SURP
    LSBio Antibodies in human, mouse, rat for U2SURP

    U2SURP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for U2SURP
    Cloud-Clone Corp. CLIAs for U2SURP
    Search eBioscience for ELISAs for U2SURP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    Selected InterPro protein domains (see all 6):
     IPR006569 CID_dom
     IPR013170 mRNA_splic_Cwf21
     IPR000061 Surp
     IPR012677 Nucleotide-bd_a/b_plait
     IPR008942 ENTH_VHS

    Graphical View of Domain Structure for InterPro Entry O15042

    ProtoNet protein and cluster: O15042

    2 Blocks protein domains:
    IPB000061 SWAP/Surp
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)


    UniProtKB/Swiss-Prot: SR140_HUMAN, O15042
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 CID domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 1 SURP motif repeat


    Find genes that share domains with U2SURP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with U2SURP           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for U2SURP:
     Increased gamma-H2AX phosphory  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for U2SURP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for U2SURP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for U2SURP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for U2SURP

    miRNA
    Products:
        
    miRTarBase miRNAs that target U2SURP:
    hsa-mir-361-5p (MIRT020074), hsa-mir-29c-3p (MIRT020376), hsa-mir-34a-5p (MIRT025568)

    Block miRNA regulation of human, mouse, rat U2SURP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate U2SURP (see all 119):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-15a hsa-miR-1224-3p hsa-miR-106a hsa-miR-200a hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for U2SURP
    Predesigned siRNA for gene silencing in human, mouse, rat U2SURP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for U2SURP

    Clone
    Products:
         
    OriGene clones in human, mouse for U2SURP (see all 9)
    OriGene ORF clones in mouse, rat for U2SURP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: U2SURP (NM_001080415)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for U2SURP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat U2SURP

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for U2SURP
    Browse ESI BIO Cell Lines and PureStem Progenitors for U2SURP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for U2SURP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SR140_HUMAN, O15042: Nucleus

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    Find genes that share ontologies with U2SURP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for U2SURP About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome


    Find genes that share SuperPaths with U2SURP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for U2SURP):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for U2SURP
    Interactions:

        Search GeneGlobe Interaction Network for U2SURP

    Selected Interacting proteins for U2SURP (O150421, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 789)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBM10P981751, 2EBI-310697,EBI-721525 MINT-7945693 MINT-8332515 MINT-8334527
    RBM5P527561, 2EBI-310697,EBI-714003 MINT-8334538 MINT-8332526
    SF3A2Q154282, 3MINT-7947479 I2D: score=1 
    DDX42Q86XP32MINT-7945693 MINT-8334560 MINT-7947479
    RBM17Q96I252MINT-7945693 MINT-7947479 MINT-8334065
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing IEA--

    Find genes that share ontologies with U2SURP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for U2SURP (SR140)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for U2SURP gene: 
    NM_001080415.1  

    Unigene Cluster for U2SURP:

    U2 snRNP-associated SURP domain containing
    Hs.596572  [show with all ESTs]
    Unigene Representative Sequence: NM_001080415
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600150 ENST00000488497 ENST00000493782 ENST00000473835 ENST00000461591(uc011bnj.1)
    ENST00000493598 ENST00000463563 ENST00000470400 ENST00000465175 ENST00000485374
    ENST00000491827 ENST00000488587 ENST00000480029(uc003evl.1) ENST00000472373
    ENST00000496100 ENST00000467348 ENST00000461844 ENST00000397933(uc003evi.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat U2SURP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate U2SURP (see all 119):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-15a hsa-miR-1224-3p hsa-miR-106a hsa-miR-200a hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for U2SURP
    Predesigned siRNA for gene silencing in human, mouse, rat U2SURP
    Clone
    Products:
         
    OriGene clones in human, mouse for U2SURP (see all 9)
    OriGene ORF clones in mouse, rat for U2SURP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: U2SURP (NM_001080415)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for U2SURP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat U2SURP
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for U2SURP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat U2SURP
      QuantiTect SYBR Green Assays in human, mouse, rat U2SURP
      QuantiFast Probe-based Assays in human, mouse, rat U2SURP

    Additional mRNA sequence: 

    AB002330.1 AF087979.1 AK057679.1 AK074327.1 AK296440.1 BC006474.1 BC016323.1 BC028110.1 
    BC045744.1 BC062727.1 BC105604.1 BC111692.1 

    Selected DOTS entries (see all 28):

    DT.119039  DT.99935078  DT.100787973  DT.40270747  DT.120911335  DT.91767442  DT.306363  DT.100890406 
    DT.91767451  DT.91767452  DT.91767456  DT.99942046  DT.100667333  DT.106930  DT.120911332  DT.119041 
    DT.100890414  DT.120911324  DT.120911379  DT.91767437  DT.120911331  DT.120911353  DT.120926599  DT.91767443 

    Selected AceView cDNA sequences (see all 414):

    AW952868 AA253230 BF477868 AA149973 BX470754 BQ214115 BQ229757 BX092741 
    N39890 AK057679 CD723261 BU190023 AL700333 AI821729 AA160004 AL707723 
    BX954710 AI799559 AU133657 BG501798 BU679513 AA252918 AA977191 BU678404 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for U2SURP (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:                                                              -                                   -                                                         
    SP2:                                                                                                  -                                                         
    SP3:                                                        -     -                                                                                             
    SP4:                                                        -     -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22 ^ 23
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for U2SURP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    U2SURP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACTGTAAA
    U2SURP Expression
    About this image


    U2SURP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    U2SURP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    U2SURP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.596572
        Custom PCR Arrays for U2SURP
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for U2SURP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat U2SURP
    QuantiTect SYBR Green Assays in human, mouse, rat U2SURP
    QuantiFast Probe-based Assays in human, mouse, rat U2SURP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for U2SURP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for U2SURP gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia U2surp1 , 5 RIKEN cDNA 2610101N10 gene5
    U2 snRNP-associated SURP domain containing1
    92.32(n)1
    99.22(a)1
      9 (50.11 cM)5
    679581  NM_001114977.11  NP_001108449.11 
     954568945 
    chicken
    (Gallus gallus)
    Aves U2SURP1 U2 snRNP-associated SURP domain containing 84.71(n)
    96.29(a)
      424773  XM_004937070.1  XP_004937127.1 
    lizard
    (Anolis carolinensis)
    Reptilia U2SURP6
    U2 snRNP-associated SURP domain containing
    89(a)
    1 ↔ 1
    3(21550453-21595089)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.26682 Xenopus laevis transcribed sequence with weak similarity more 78.34(n)    CA983194.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK027960.12   -- 76.78(n)   337859  CK027960.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93461 CG9346 55.31(n)
    52.84(a)
      37381  NM_137691.2  NP_611535.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C07H6.41 C07H6.4 49.68(n)
    38.96(a)
      176063  NM_066247.5  NP_498648.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G250601 AT5G25060 50.83(n)
    42.53(a)
      832577  NM_122415.1  NP_568464.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01799001 Os02g0179900   --   4328504  NM_001052622.1  NP_001046087.1 


    ENSEMBL Gene Tree for U2SURP (if available)
    TreeFam Gene Tree for U2SURP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for U2SURP gene
    2 SIMAP similar genes for U2SURP using alignment to 11 protein entries:     SR140_HUMAN (see all proteins):
    RBMY1A1    PABPC1

    Find genes that share paralogs with U2SURP           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for U2SURP
    PGOHUM00000238063


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for U2SURP (see all 1188)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816289941,2
    --142718373(+) AGGCTA/GTGGCA 1 -- us2k10--------
    rs1456027191,2
    --142718428(+) GATCAC/TGCCAC 1 -- us2k10--------
    rs1480857981,2
    --142718540(+) TATAGA/GTTCCT 1 -- us2k10--------
    rs1162342211,2
    F--142718630(+) CCAGAG/ATAGAA 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1130517551,2
    C,F--142718646(+) TTAGAT/CTTCAA 1 -- us2k12Minor allele frequency- C:0.33CSA 3
    rs1906151121,2
    --142718764(+) ATTTCA/GTGTGT 1 -- us2k10--------
    rs1418549641,2
    C--142718804(+) TTTACC/TGTCTG 1 -- us2k10--------
    rs599434701,2
    C--142719024(+) CCCCCC/TGCCCC 1 -- us2k13Minor allele frequency- T:0.20WA NA CSA 5
    rs2005730821,2
    C--142719030(+) GCCCCC/GCCCCG 1 -- us2k10--------
    rs1382998521,2
    C--142719161(+) TCCTC-/CATTTCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for U2SURP (142683339 - 142779567 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for U2SURP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877563CNV Loss21882294
    nsv513081CNV Loss21212237
    nsv877562CNV Gain21882294
    dgv1515e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for U2SURP gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with U2SURP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PubMed id 12234937)1, 2, 3 Will C.L.... Luehrmann R. (EMBO J. 2002)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    3. Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity. (PubMed id 23741361)1 Wang W....Zhou Y. (PLoS ONE 2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    6. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (J. Cell Biol. 2012)
    7. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
    8. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    9. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23350 HGNC: 30855 AceView: SR140 Ensembl:ENSG00000163714 euGenes: HUgn23350
    ECgene: U2SURP Kegg: 23350 H-InvDB: U2SURP

    (According to HUGE)
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    HUGE: KIAA0332

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for U2SURP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for U2SURP gene:
    Search GeneIP for patents involving U2SURP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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