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Aliases for U2SURP Gene

Aliases for U2SURP Gene

  • U2 SnRNP-Associated SURP Domain Containing 2 3
  • Functional Spliceosome-Associated Protein A 2 3
  • 140 KDa Ser/Arg-Rich Domain Protein 3 4
  • U2 Associated SR140 Protein 2 3
  • U2-Associated Protein SR140 3 4
  • SR140 3 4
  • U2 SnRNP-Associated SURP Motif-Containing Protein 3
  • Ser/Arg-Rich Domain Protein, 140 KDa 3
  • Ser/Arg-Rich Domain Protein 2
  • U2-Associated SR140 Protein 3
  • KIAA0332 4
  • 140 KDa 2
  • FSAPa 3

External Ids for U2SURP Gene

Summaries for U2SURP Gene

GeneCards Summary for U2SURP Gene

U2SURP (U2 SnRNP-Associated SURP Domain Containing) is a Protein Coding gene. Among its related pathways are Spliceosome. GO annotations related to this gene include RNA binding and nucleotide binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for U2SURP Gene

Genomics for U2SURP Gene

Genomic Location for U2SURP Gene

Start:
142,964,497 bp from pter
End:
143,060,725 bp from pter
Size:
96,229 bases
Orientation:
Plus strand

Genomic View for U2SURP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for U2SURP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for U2SURP Gene

No data available for Regulatory Elements for U2SURP Gene

Proteins for U2SURP Gene

  • Protein details for U2SURP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15042-SR140_HUMAN
    Recommended name:
    U2 snRNP-associated SURP motif-containing protein
    Protein Accession:
    O15042
    Secondary Accessions:
    • A0PJ60
    • Q0D2M1
    • Q2NKQ7
    • Q9BR70

    Protein attributes for U2SURP Gene

    Size:
    1029 amino acids
    Molecular mass:
    118292 Da
    Quaternary structure:
    • Interacts with ERBB4.
    SequenceCaution:
    • Sequence=AAH16323.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI05605.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for U2SURP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for U2SURP Gene

Proteomics data for U2SURP Gene at MOPED

Post-translational modifications for U2SURP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys476, Lys488, Lys541, and Lys622

No data available for DME Specific Peptides for U2SURP Gene

Domains for U2SURP Gene

Gene Families for U2SURP Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for U2SURP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15042

UniProtKB/Swiss-Prot:

SR140_HUMAN
Domain:
  • Contains 1 CID domain.:
    • O15042
  • Contains 1 RRM (RNA recognition motif) domain.:
    • O15042
Family:
  • Belongs to the splicing factor SR family.:
    • O15042
Similarity:
  • Contains 1 SURP motif repeat.:
    • O15042
genes like me logo Genes that share domains with U2SURP: view

Function for U2SURP Gene

Gene Ontology (GO) - Molecular Function for U2SURP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 20858735
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with U2SURP: view

Phenotypes for U2SURP Gene

genes like me logo Genes that share phenotypes with U2SURP: view

miRNA for U2SURP Gene

miRTarBase miRNAs that target U2SURP

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for U2SURP Gene

Localization for U2SURP Gene

Subcellular locations from UniProtKB/Swiss-Prot for U2SURP Gene

Gene Ontology (GO) - Cellular Components for U2SURP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20858735
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with U2SURP: view

No data available for Subcellular locations from COMPARTMENTS for U2SURP Gene

Pathways for U2SURP Gene

SuperPathways for U2SURP Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with U2SURP: view

Pathways by source for U2SURP Gene

1 KEGG pathway for U2SURP Gene

Gene Ontology (GO) - Biological Process for U2SURP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with U2SURP: view

Transcripts for U2SURP Gene

Unigene Clusters for U2SURP Gene

U2 snRNP-associated SURP domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for U2SURP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:

ExUns: 21b ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for U2SURP Gene

GeneLoc Exon Structure for
U2SURP
ECgene alternative splicing isoforms for
U2SURP

Expression for U2SURP Gene

mRNA expression in normal human tissues for U2SURP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for U2SURP Gene

SOURCE GeneReport for Unigene cluster for U2SURP Gene Hs.596572

genes like me logo Genes that share expressions with U2SURP: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for U2SURP Gene

Orthologs for U2SURP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for U2SURP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U2SURP 35
  • 99.84 (n)
  • 99.9 (a)
U2SURP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia U2SURP 35
  • 95.66 (n)
  • 99.51 (a)
U2SURP 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia U2SURP 35
  • 95.95 (n)
  • 99.9 (a)
U2SURP 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia U2surp 35
  • 92.32 (n)
  • 99.22 (a)
U2surp 16
U2surp 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia U2SURP 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia U2surp 35
  • 92.61 (n)
  • 99.22 (a)
chicken
(Gallus gallus)
Aves U2SURP 35
  • 84.71 (n)
  • 96.29 (a)
U2SURP 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia U2SURP 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2668 35
tropical clawed frog
(Silurana tropicalis)
Amphibia u2surp 35
  • 79.42 (n)
  • 89.05 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
u2surp 35
  • 72.18 (n)
  • 78.27 (a)
u2surp 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005006 35
  • 53.43 (n)
  • 51.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9346 35
  • 55.31 (n)
  • 52.84 (a)
CG9346 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C07H6.4 35
  • 49.68 (n)
  • 38.96 (a)
C07H6.4 36
  • 32 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G25060 35
  • 50.83 (n)
  • 42.53 (a)
rice
(Oryza sativa)
Liliopsida Os02g0179900 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for U2SURP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for U2SURP Gene

ENSEMBL:
Gene Tree for U2SURP (if available)
TreeFam:
Gene Tree for U2SURP (if available)

Paralogs for U2SURP Gene

Pseudogenes.org Pseudogenes for U2SURP Gene

genes like me logo Genes that share paralogs with U2SURP: view

No data available for Paralogs for U2SURP Gene

Variants for U2SURP Gene

Sequence variations from dbSNP and Humsavar for U2SURP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8831 -- 143,060,153(+) TTTTG(C/T)AGATT utr-variant-3-prime
rs10413 -- 143,060,452(-) TTTAT(A/G)TAGAA utr-variant-3-prime, downstream-variant-500B
rs10790 -- 143,059,824(+) GAACA(C/T)GTGAC utr-variant-3-prime
rs13715 -- 143,060,190(+) CATGT(A/G)ATTGT utr-variant-3-prime, downstream-variant-500B
rs936194 -- 143,041,848(+) GGTTA(C/T)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for U2SURP Gene

Variant ID Type Subtype PubMed ID
nsv877562 CNV Gain 21882294
nsv877563 CNV Loss 21882294
dgv1515e1 CNV Complex 17122850
nsv513081 CNV Loss 21212237

Relevant External Links for U2SURP Gene

HapMap Linkage Disequilibrium report
U2SURP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for U2SURP Gene

Disorders for U2SURP Gene

No disorders were found for U2SURP Gene.

No data available for UniProtKB/Swiss-Prot for U2SURP Gene

Publications for U2SURP Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PMID: 12234937) Will C.L. … Luehrmann R. (EMBO J. 2002) 2 3 4
  3. Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways. (PMID: 20858735) Gilmore-Hebert M. … Stern D.F. (Mol. Cancer Res. 2010) 3 4
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for U2SURP Gene

  • antibodies-online peptides for U2SURP
  • antibodies-online antibodies for U2SURP
  • antibodies-online kits for U2SURP

Sources for U2SURP Gene

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