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Aliases for U2SURP Gene

Aliases for U2SURP Gene

  • U2 SnRNP Associated SURP Domain Containing 2 3 5
  • Functional Spliceosome-Associated Protein A 2 3
  • Ser/Arg-Rich Domain Protein, 140 KDa 2 3
  • 140 KDa Ser/Arg-Rich Domain Protein 3 4
  • U2-Associated Protein SR140 3 4
  • SR140 3 4
  • U2 SnRNP-Associated SURP Motif-Containing Protein 3
  • U2 SnRNP-Associated SURP Domain Containing 2
  • U2 Associated SR140 Protein 2
  • U2-Associated SR140 Protein 3
  • KIAA0332 4
  • FSAPa 3

External Ids for U2SURP Gene

Previous GeneCards Identifiers for U2SURP Gene

  • GC03P142720
  • GC03P142683

Summaries for U2SURP Gene

GeneCards Summary for U2SURP Gene

U2SURP (U2 SnRNP Associated SURP Domain Containing) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for U2SURP Gene

Genomics for U2SURP Gene

Regulatory Elements for U2SURP Gene

Enhancers for U2SURP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G142997 1.4 ENCODE dbSUPER 6.9 +35.9 35925 6.2 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A XRN1 ST13P15 PAQR9-AS1 PAQR9 PBX2P1 LOC100507389 RNA5SP143 PLS1 U2SURP LOC100289361
GH03G142828 0.9 ENCODE 10.4 -135.6 -135614 0.2 ATF1 RB1 ARID4B ZNF48 RAD21 RFX5 SCRT2 ZNF143 CREM MIXL1 PCOLCE2 LOC100507389 U2SURP RPL8P3
GH03G143070 0.7 Ensembl ENCODE 6.5 +106.9 106906 1.6 TBX3 CTCF FOXA2 U2SURP LOC105374138 GC03M142971
GH03G143003 0.5 Ensembl 6.6 +39.7 39704 0.8 ZNF316 NR2F1 GLIS1 NR2F6 U2SURP LOC100289361 GC03M142971
GH03G143036 0.5 ENCODE 6.5 +72.4 72443 0.8 PAF1 RAD51 RFX1 BMI1 MYC U2SURP GC03M142971 LOC105374138
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around U2SURP on UCSC Golden Path with GeneCards custom track

Promoters for U2SURP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000159481 276 3201 PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for U2SURP Gene

Chromosome:
3
Start:
142,964,497 bp from pter
End:
143,060,725 bp from pter
Size:
96,229 bases
Orientation:
Plus strand

Genomic View for U2SURP Gene

Genes around U2SURP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
U2SURP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for U2SURP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for U2SURP Gene

Proteins for U2SURP Gene

  • Protein details for U2SURP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15042-SR140_HUMAN
    Recommended name:
    U2 snRNP-associated SURP motif-containing protein
    Protein Accession:
    O15042
    Secondary Accessions:
    • A0PJ60
    • Q0D2M1
    • Q2NKQ7
    • Q9BR70

    Protein attributes for U2SURP Gene

    Size:
    1029 amino acids
    Molecular mass:
    118292 Da
    Quaternary structure:
    • Interacts with ERBB4.
    SequenceCaution:
    • Sequence=AAH16323.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI05605.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for U2SURP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for U2SURP Gene

Post-translational modifications for U2SURP Gene

  • Ubiquitination at posLast=476476 and Lys622
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for U2SURP Gene

Domains & Families for U2SURP Gene

Gene Families for U2SURP Gene

Suggested Antigen Peptide Sequences for U2SURP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15042

UniProtKB/Swiss-Prot:

SR140_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with U2SURP: view

Function for U2SURP Gene

Gene Ontology (GO) - Molecular Function for U2SURP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22681889
GO:0005515 protein binding IPI 20858735
genes like me logo Genes that share ontologies with U2SURP: view
genes like me logo Genes that share phenotypes with U2SURP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for U2SURP Gene

Localization for U2SURP Gene

Subcellular locations from UniProtKB/Swiss-Prot for U2SURP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for U2SURP gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for U2SURP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 20858735
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with U2SURP: view

Pathways & Interactions for U2SURP Gene

genes like me logo Genes that share pathways with U2SURP: view

Pathways by source for U2SURP Gene

Gene Ontology (GO) - Biological Process for U2SURP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with U2SURP: view

No data available for SIGNOR curated interactions for U2SURP Gene

Drugs & Compounds for U2SURP Gene

No Compound Related Data Available

Transcripts for U2SURP Gene

Unigene Clusters for U2SURP Gene

U2 snRNP-associated SURP domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for U2SURP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:

ExUns: 21b ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for U2SURP Gene

GeneLoc Exon Structure for
U2SURP
ECgene alternative splicing isoforms for
U2SURP

Expression for U2SURP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for U2SURP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for U2SURP Gene

This gene is overexpressed in Lymph node (13.2), Fetal testis (6.4), and Blymphocyte (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for U2SURP Gene



Protein tissue co-expression partners for U2SURP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of U2SURP Gene:

U2SURP

SOURCE GeneReport for Unigene cluster for U2SURP Gene:

Hs.596572

Evidence on tissue expression from TISSUES for U2SURP Gene

  • Nervous system(4.8)
  • Lung(4.5)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with U2SURP: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for U2SURP Gene

Orthologs for U2SURP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for U2SURP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U2SURP 34 35
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia U2SURP 34 35
  • 95.95 (n)
cow
(Bos Taurus)
Mammalia U2SURP 34 35
  • 95.66 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
OneToMany
-- 35
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia U2surp 34
  • 92.61 (n)
mouse
(Mus musculus)
Mammalia U2surp 34 16 35
  • 92.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia U2SURP 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves U2SURP 34 35
  • 84.71 (n)
lizard
(Anolis carolinensis)
Reptilia U2SURP 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia u2surp 34
  • 79.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2668 34
zebrafish
(Danio rerio)
Actinopterygii u2surp 34 35
  • 72.18 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG9346 34 35
  • 55.31 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005006 34
  • 53.43 (n)
worm
(Caenorhabditis elegans)
Secernentea C07H6.4 34 35
  • 49.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G25060 34
  • 50.83 (n)
rice
(Oryza sativa)
Liliopsida Os02g0179900 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToOne
Species where no ortholog for U2SURP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for U2SURP Gene

ENSEMBL:
Gene Tree for U2SURP (if available)
TreeFam:
Gene Tree for U2SURP (if available)

Paralogs for U2SURP Gene

Pseudogenes.org Pseudogenes for U2SURP Gene

genes like me logo Genes that share paralogs with U2SURP: view

No data available for Paralogs for U2SURP Gene

Variants for U2SURP Gene

Sequence variations from dbSNP and Humsavar for U2SURP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000027194 -- 143,054,358(+) AAGCC(A/T)TTGCA intron-variant
rs1000027376 -- 143,059,570(+) TTGTT(A/T)TTCAA utr-variant-3-prime
rs1000028725 -- 143,044,725(+) GTACT(A/G)TCTCC intron-variant
rs1000055500 -- 143,037,084(+) ATCCA(A/G)TTATG intron-variant
rs1000058283 -- 143,054,045(+) GGATT(C/G)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for U2SURP Gene

Variant ID Type Subtype PubMed ID
dgv4913n100 CNV gain 25217958
esv2759183 CNV gain 17122850
esv3598015 CNV gain 21293372
esv3598016 CNV gain 21293372
nsv513081 CNV loss 21212237
nsv591921 CNV loss 21841781

Variation tolerance for U2SURP Gene

Residual Variation Intolerance Score: 4.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for U2SURP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
U2SURP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for U2SURP Gene

Disorders for U2SURP Gene

Relevant External Links for U2SURP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
U2SURP

No disorders were found for U2SURP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for U2SURP Gene

Publications for U2SURP Gene

  1. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PMID: 12234937) Will C.L. … Luehrmann R. (EMBO J. 2002) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 64
  3. Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways. (PMID: 20858735) Gilmore-Hebert M. … Stern D.F. (Mol. Cancer Res. 2010) 3 4 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for U2SURP Gene

Sources for U2SURP Gene

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