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Aliases for U2AF2 Gene

Aliases for U2AF2 Gene

  • U2 Small Nuclear RNA Auxiliary Factor 2 2 3 5
  • U2 SnRNP Auxiliary Factor Large Subunit 2 3 4
  • U2 Small Nuclear Ribonucleoprotein Auxiliary Factor (65kD) 2 3
  • U2 (RNU2) Small Nuclear RNA Auxiliary Factor 2 2 3
  • U2 Auxiliary Factor 65 KDa Subunit 3 4
  • HU2AF65 3 4
  • U2AF65 3 4
  • Splicing Factor U2AF 65 KDa Subunit 3
  • Splicing Factor U2AF 65 KD Subunit 2
  • HU2AF(65) 4

External Ids for U2AF2 Gene

Previous GeneCards Identifiers for U2AF2 Gene

  • GC19P060857
  • GC19P060858
  • GC19P056165
  • GC19P052475

Summaries for U2AF2 Gene

Entrez Gene Summary for U2AF2 Gene

  • U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

GeneCards Summary for U2AF2 Gene

U2AF2 (U2 Small Nuclear RNA Auxiliary Factor 2) is a Protein Coding gene. Among its related pathways are Transport of Mature Transcript to Cytoplasm and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is UHMK1.

UniProtKB/Swiss-Prot for U2AF2 Gene

  • Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.

Gene Wiki entry for U2AF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for U2AF2 Gene

Genomics for U2AF2 Gene

Regulatory Elements for U2AF2 Gene

Enhancers for U2AF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055215 0.2 ENCODE 95.2 -437.3 -437346 2.9 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 U2AF2 LENG8-AS1 ENSG00000235681 ENSG00000267523 ZNF581 ZNF628 ZNF580 ENSG00000267096 KMT5C RFPL4AP1
GH19F056594 0.9 ENCODE 59.8 +941.4 941391 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A YBX1 FEZF1 GLI4 ZNF48 ETS1 ZNF773 ZNF550 U2AF2 ZNF543 ZNF264 ZNF17 ENSG00000267523 ZNF549 ENSG00000267096 ZFP28
GH19F055503 1.1 Ensembl ENCODE 33.1 -150.1 -150082 1.6 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF416 ZNF143 ZNF548 U2AF2 ZNF667 FIZ1 ZNF667-AS1 NAT14 LOC100506374 ZNF580 ZNF582-AS1 ENSG00000267523 KMT5C
GH19F055062 1 ENCODE 27.2 -591.2 -591171 1.7 PKNOX1 ATF1 SIN3A DMAP1 ZNF48 BRCA1 GTF3C2 GLIS2 ELK1 FOS ENSG00000235681 LENG8-AS1 U2AF2 ZNF581 ENSG00000267523 RDH13 PRPF31 ENSG00000267265 ZNF628 ENSG00000267096
GH19F055519 1 FANTOM5 Ensembl ENCODE 22.8 -133.8 -133841 1.0 HDGF ATF1 ZNF493 ZNF133 GLI4 YBX1 ZNF416 ZNF548 FOS MCM3 FIZ1 ZNF580 NAT14 U2AF2 SHISA7 ZNF667 ZNF667-AS1 SSC5D SBK3 LOC100506374
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around U2AF2 on UCSC Golden Path with GeneCards custom track

Promoters for U2AF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000349055 850 3401 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for U2AF2 Gene

Chromosome:
19
Start:
55,654,050 bp from pter
End:
55,674,716 bp from pter
Size:
20,667 bases
Orientation:
Plus strand

Genomic View for U2AF2 Gene

Genes around U2AF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
U2AF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for U2AF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for U2AF2 Gene

Proteins for U2AF2 Gene

  • Protein details for U2AF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26368-U2AF2_HUMAN
    Recommended name:
    Splicing factor U2AF 65 kDa subunit
    Protein Accession:
    P26368
    Secondary Accessions:
    • Q96HC5

    Protein attributes for U2AF2 Gene

    Size:
    475 amino acids
    Molecular mass:
    53501 Da
    Quaternary structure:
    • Interacts with U2AF1L4 (By similarity). Heterodimer with U2AF1. Binds unphosphorylated SF1. Interacts with SCAF11 and SNW1. Interacts with ZRSR2/U2AF1-RS2. Interacts with RBM17. Interacts with PRPF19; the interaction is direct. Interacts with POLR2A (via the C-terminal domain); recruits PRPF19 and the Prp19 complex to the pre-mRNA.

    Three dimensional structures from OCA and Proteopedia for U2AF2 Gene

    Alternative splice isoforms for U2AF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for U2AF2 Gene

Post-translational modifications for U2AF2 Gene

  • Lysyl-hydroxylation at Lys-15 and Lys-276 affects the mRNA splicing activity of the protein, leading to regulate some, but not all, alternative splicing events.
  • Ubiquitination at Lys 286, Lys 413, and Lys 431
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for U2AF2 Gene

Domains & Families for U2AF2 Gene

Gene Families for U2AF2 Gene

Suggested Antigen Peptide Sequences for U2AF2 Gene

Graphical View of Domain Structure for InterPro Entry

P26368

UniProtKB/Swiss-Prot:

U2AF2_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
  • Belongs to the splicing factor SR family.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with U2AF2: view

Function for U2AF2 Gene

Molecular function for U2AF2 Gene

UniProtKB/Swiss-Prot Function:
Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.

Gene Ontology (GO) - Molecular Function for U2AF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 9237760
GO:0008187 poly-pyrimidine tract binding IBA --
genes like me logo Genes that share ontologies with U2AF2: view
genes like me logo Genes that share phenotypes with U2AF2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for U2AF2 Gene

Localization for U2AF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for U2AF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for U2AF2 Gene COMPARTMENTS Subcellular localization image for U2AF2 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for U2AF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000243 commitment complex IBA --
GO:0000974 colocalizes_with Prp19 complex IDA 21536736
GO:0005634 nucleus IEA,IDA 1824937
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
genes like me logo Genes that share ontologies with U2AF2: view

Pathways & Interactions for U2AF2 Gene

genes like me logo Genes that share pathways with U2AF2: view

Pathways by source for U2AF2 Gene

1 KEGG pathway for U2AF2 Gene

Gene Ontology (GO) - Biological Process for U2AF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing IEA,TAS 1538748
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with U2AF2: view

No data available for SIGNOR curated interactions for U2AF2 Gene

Drugs & Compounds for U2AF2 Gene

(4) Drugs for U2AF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for U2AF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with U2AF2: view

Transcripts for U2AF2 Gene

Unigene Clusters for U2AF2 Gene

U2 small nuclear RNA auxiliary factor 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for U2AF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: -
SP2:

Relevant External Links for U2AF2 Gene

GeneLoc Exon Structure for
U2AF2
ECgene alternative splicing isoforms for
U2AF2

Expression for U2AF2 Gene

mRNA expression in normal human tissues for U2AF2 Gene

Protein differential expression in normal tissues from HIPED for U2AF2 Gene

This gene is overexpressed in Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for U2AF2 Gene



Protein tissue co-expression partners for U2AF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of U2AF2 Gene:

U2AF2

SOURCE GeneReport for Unigene cluster for U2AF2 Gene:

Hs.528007
genes like me logo Genes that share expression patterns with U2AF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for U2AF2 Gene

Orthologs for U2AF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for U2AF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U2AF2 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia U2AF2 34 35
  • 93.54 (n)
dog
(Canis familiaris)
Mammalia U2AF2 34 35
  • 93.12 (n)
rat
(Rattus norvegicus)
Mammalia U2af2 34
  • 91.79 (n)
mouse
(Mus musculus)
Mammalia U2af2 34 16 35
  • 91.3 (n)
lizard
(Anolis carolinensis)
Reptilia U2AF2 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia u2af2 34
  • 78.52 (n)
Str.5829 34
African clawed frog
(Xenopus laevis)
Amphibia u2af2-prov 34
zebrafish
(Danio rerio)
Actinopterygii u2af2b 35
  • 86 (a)
OneToMany
u2af2a 34 35
  • 76.92 (n)
wufb73g02 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002908 34
  • 68.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta U2af50 34 35
  • 68.29 (n)
worm
(Caenorhabditis elegans)
Secernentea uaf-1 34
  • 57.34 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G60900 34
  • 50.89 (n)
rice
(Oryza sativa)
Liliopsida Os11g0636900 34
  • 52.46 (n)
Os.27324 34
barley
(Hordeum vulgare)
Liliopsida Hv.4847 34
corn
(Zea mays)
Liliopsida Zm.15495 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2917 35
  • 61 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03039 34
  • 52.89 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp2 34
  • 42.17 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12469 34
Species where no ortholog for U2AF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for U2AF2 Gene

ENSEMBL:
Gene Tree for U2AF2 (if available)
TreeFam:
Gene Tree for U2AF2 (if available)

Paralogs for U2AF2 Gene

Paralogs for U2AF2 Gene

genes like me logo Genes that share paralogs with U2AF2: view

Variants for U2AF2 Gene

Sequence variations from dbSNP and Humsavar for U2AF2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401552 -- 55,663,271(+) CCTCA(C/G)CAGAA intron-variant
rs10402618 -- 55,672,317(+) TTTTC(A/G)TATTC intron-variant
rs10412372 -- 55,668,082(+) cggcc(A/G)GGACT intron-variant
rs10420401 -- 55,662,146(+) CTCTT(C/G)TGTTT intron-variant
rs10422307 -- 55,665,472(+) CCATG(C/G)ACGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for U2AF2 Gene

Variant ID Type Subtype PubMed ID
dgv1822n106 CNV tandem duplication 24896259
esv1128019 CNV insertion 17803354
esv2718987 CNV deletion 23290073
esv3349569 CNV duplication 20981092
nsv1061024 CNV gain 25217958
nsv2553 CNV insertion 18451855
nsv522559 CNV loss 19592680
nsv828644 CNV gain 20364138
nsv833882 CNV loss 17160897
nsv953625 CNV deletion 24416366

Variation tolerance for U2AF2 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for U2AF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
U2AF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for U2AF2 Gene

Disorders for U2AF2 Gene

Relevant External Links for U2AF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
U2AF2

No disorders were found for U2AF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for U2AF2 Gene

Publications for U2AF2 Gene

  1. Cloning and domain structure of the mammalian splicing factor U2AF. (PMID: 1538748) Zamore P.D. … Green M.R. (Nature 1992) 2 3 4 22 64
  2. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PMID: 19574390) Webby C.J. … Boettger A. (Science 2009) 3 4 22 64
  3. A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer. (PMID: 11551507) Kielkopf C.L. … Burley S.K. (Cell 2001) 3 4 22 64
  4. Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF(65)). (PMID: 10449418) Ito T. … Yokoyama S. (EMBO J. 1999) 3 4 22 64
  5. A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA. (PMID: 9237760) Tronchere H. … Fu X.D. (Nature 1997) 3 4 22 64

Products for U2AF2 Gene

Sources for U2AF2 Gene

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