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Aliases for U2AF2 Gene

Aliases for U2AF2 Gene

  • U2 Small Nuclear RNA Auxiliary Factor 2 2 3
  • U2 SnRNP Auxiliary Factor Large Subunit 2 3 4
  • U2 Small Nuclear Ribonucleoprotein Auxiliary Factor (65kD) 2 3
  • U2 (RNU2) Small Nuclear RNA Auxiliary Factor 2 2 3
  • U2 Auxiliary Factor 65 KDa Subunit 3 4
  • HU2AF65 3 4
  • U2AF65 3 4
  • Splicing Factor U2AF 65 KDa Subunit 3
  • Splicing Factor U2AF 65 KD Subunit 2
  • HU2AF(65) 4

External Ids for U2AF2 Gene

Previous GeneCards Identifiers for U2AF2 Gene

  • GC19P060857
  • GC19P060858
  • GC19P056165
  • GC19P052475

Summaries for U2AF2 Gene

Entrez Gene Summary for U2AF2 Gene

  • U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

GeneCards Summary for U2AF2 Gene

U2AF2 (U2 Small Nuclear RNA Auxiliary Factor 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include RNA binding and enzyme binding. An important paralog of this gene is UHMK1.

UniProtKB/Swiss-Prot for U2AF2 Gene

  • Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.

Gene Wiki entry for U2AF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for U2AF2 Gene

Genomics for U2AF2 Gene

Regulatory Elements for U2AF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for U2AF2 Gene

Start:
55,654,050 bp from pter
End:
55,674,716 bp from pter
Size:
20,667 bases
Orientation:
Plus strand

Genomic View for U2AF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for U2AF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for U2AF2 Gene

Proteins for U2AF2 Gene

  • Protein details for U2AF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26368-U2AF2_HUMAN
    Recommended name:
    Splicing factor U2AF 65 kDa subunit
    Protein Accession:
    P26368
    Secondary Accessions:
    • Q96HC5

    Protein attributes for U2AF2 Gene

    Size:
    475 amino acids
    Molecular mass:
    53501 Da
    Quaternary structure:
    • Interacts with U2AF1L4 (By similarity). Heterodimer with U2AF1. Binds unphosphorylated SF1. Interacts with SCAF11 and SNW1. Interacts with ZRSR2/U2AF1-RS2. Interacts with RBM17. Interacts with PRPF19; the interaction is direct. Interacts with POLR2A (via the C-terminal domain); recruits PRPF19 and the Prp19 complex to the pre-mRNA.

    Three dimensional structures from OCA and Proteopedia for U2AF2 Gene

    Alternative splice isoforms for U2AF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for U2AF2 Gene

Proteomics data for U2AF2 Gene at MOPED

Post-translational modifications for U2AF2 Gene

  • Lysyl-hydroxylation at Lys-15 and Lys-276 affects the mRNA splicing activity of the protein, leading to regulate some, but not all, alternative splicing events.
  • Ubiquitination at Lys286, Lys413, and Lys431
  • Modification sites at PhosphoSitePlus

Other Protein References for U2AF2 Gene

No data available for DME Specific Peptides for U2AF2 Gene

Domains for U2AF2 Gene

Gene Families for U2AF2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for U2AF2 Gene

Suggested Antigen Peptide Sequences for U2AF2 Gene

Graphical View of Domain Structure for InterPro Entry

P26368

UniProtKB/Swiss-Prot:

U2AF2_HUMAN :
  • P26368
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with U2AF2: view

Function for U2AF2 Gene

Molecular function for U2AF2 Gene

UniProtKB/Swiss-Prot Function: Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.

Gene Ontology (GO) - Molecular Function for U2AF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 11551507
GO:0019899 enzyme binding IPI 19574390
genes like me logo Genes that share ontologies with U2AF2: view
genes like me logo Genes that share phenotypes with U2AF2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for U2AF2 Gene

Localization for U2AF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for U2AF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for U2AF2 Gene COMPARTMENTS Subcellular localization image for U2AF2 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for U2AF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000974 colocalizes_with Prp19 complex IDA 21536736
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0016607 nuclear speck IDA 21984414
genes like me logo Genes that share ontologies with U2AF2: view

Pathways for U2AF2 Gene

genes like me logo Genes that share pathways with U2AF2: view

Gene Ontology (GO) - Biological Process for U2AF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing TAS 1538748
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with U2AF2: view

Compounds for U2AF2 Gene

(7) Novoseek inferred chemical compound relationships for U2AF2 Gene

Compound -log(P) Hits PubMed IDs
poly u 56.4 2
arginine 29.9 2
pyrimidine 21.5 2
serine 7.13 1
adenylate 0.655 2
genes like me logo Genes that share compounds with U2AF2: view

Transcripts for U2AF2 Gene

Unigene Clusters for U2AF2 Gene

U2 small nuclear RNA auxiliary factor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for U2AF2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for U2AF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: -
SP2:

Relevant External Links for U2AF2 Gene

GeneLoc Exon Structure for
U2AF2
ECgene alternative splicing isoforms for
U2AF2

Expression for U2AF2 Gene

mRNA expression in normal human tissues for U2AF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for U2AF2 Gene

SOURCE GeneReport for Unigene cluster for U2AF2 Gene Hs.528007

genes like me logo Genes that share expressions with U2AF2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for U2AF2 Gene

Orthologs for U2AF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for U2AF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U2AF2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia U2AF2 35
  • 93.54 (n)
  • 99.58 (a)
U2AF2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia U2AF2 35
  • 93.12 (n)
  • 100 (a)
U2AF2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia U2af2 35
  • 91.3 (n)
  • 100 (a)
U2af2 16
U2af2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia U2af2 35
  • 91.79 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia U2AF2 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia u2af2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5829 35
u2af2 35
  • 78.52 (n)
  • 96.22 (a)
zebrafish
(Danio rerio)
Actinopterygii u2af2a 35
  • 76.92 (n)
  • 90.11 (a)
u2af2a 36
  • 87 (a)
OneToMany
u2af2b 36
  • 86 (a)
OneToMany
wufb73g02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002908 35
  • 68.6 (n)
  • 75.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta U2af50 35
  • 68.29 (n)
  • 74.62 (a)
U2af50 36
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea uaf-1 35
  • 57.34 (n)
  • 62.69 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G60900 35
  • 50.89 (n)
  • 45.32 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4847 35
corn
(Zea mays)
Liliopsida Zm.15495 35
rice
(Oryza sativa)
Liliopsida Os.27324 35
Os11g0636900 35
  • 52.46 (n)
  • 47.91 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03039 35
  • 52.89 (n)
  • 44.97 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp2 35
  • 42.17 (n)
  • 34.43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12469 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2917 36
  • 61 (a)
OneToOne
Species with no ortholog for U2AF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for U2AF2 Gene

ENSEMBL:
Gene Tree for U2AF2 (if available)
TreeFam:
Gene Tree for U2AF2 (if available)

Paralogs for U2AF2 Gene

Paralogs for U2AF2 Gene

genes like me logo Genes that share paralogs with U2AF2: view

Variants for U2AF2 Gene

Sequence variations from dbSNP and Humsavar for U2AF2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs188701 -- 55,665,582(-) GTAGA(A/C)CTGCC intron-variant
rs310436 -- 55,667,193(-) CTCCC(A/G)CCTAC intron-variant
rs310437 -- 55,666,330(-) CTGCA(A/G)CGGCT intron-variant
rs310438 -- 55,665,932(-) GGAGC(A/G)GTGGC intron-variant
rs310439 -- 55,664,979(-) ACACT(C/T)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for U2AF2 Gene

Variant ID Type Subtype PubMed ID
dgv4025n71 CNV Loss 21882294
nsv912500 CNV Loss 21882294
nsv912501 CNV Loss 21882294
nsv2553 CNV Insertion 18451855
nsv912504 CNV Loss 21882294
nsv833882 CNV Loss 17160897
esv2718987 CNV Deletion 23290073
esv1128019 CNV Insertion 17803354
nsv828644 CNV Gain 20364138
nsv522559 CNV Loss 19592680

Relevant External Links for U2AF2 Gene

HapMap Linkage Disequilibrium report
U2AF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for U2AF2 Gene

Disorders for U2AF2 Gene

No disorders were found for U2AF2 Gene.

No data available for UniProtKB/Swiss-Prot for U2AF2 Gene

Publications for U2AF2 Gene

  1. Cloning and domain structure of the mammalian splicing factor U2AF. (PMID: 1538748) Zamore P.D. … Green M.R. (Nature 1992) 2 3 4 23
  2. A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA. (PMID: 9237760) Tronchere H. … Fu X.D. (Nature 1997) 3 4 23
  3. Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF(65)). (PMID: 10449418) Ito T. … Yokoyama S. (EMBO J. 1999) 3 4 23
  4. A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer. (PMID: 11551507) Kielkopf C.L. … Burley S.K. (Cell 2001) 3 4 23
  5. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PMID: 19574390) Webby C.J. … Boettger A. (Science 2009) 3 4 23

Products for U2AF2 Gene

Sources for U2AF2 Gene

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