U2AF2 Gene
protein-coding GIFtS: 53
GCID: GC19P056165
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|
U2 small nuclear RNA auxiliary factor 2(Previous name: U2 (RNU2) small nuclear RNA auxiliary factor 2 )
| |
Aliases
for U2AF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| U2 Small Nuclear RNA Auxiliary Factor 21 2 | | U2 SnRNP Auxiliary Factor Large Subunit2 3 | | U2AF651 2 3 | | Splicing Factor U2AF 65 KDa Subunit2 | | U2 (RNU2) Small Nuclear RNA Auxiliary Factor 21 2 | | U2 Small Nuclear Ribonucleoprotein Auxiliary Factor (65kD)2 | | HU2AF651 | | HU2AF(65)1 | | U2 Auxiliary Factor 65 KDa Subunit2 3 | | |
Export aliases for U2AF2 gene to outside databasesPrevious GC identifers: GC19P060857 GC19P060858 GC19P052475 |
Summaries
for U2AF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for U2AF2:
U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the bindingof U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specificRNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunitbinds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have beendetected for this gene, but the full-length natures of only two have been determined to date. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: U2AF2_HUMAN, P26368Function: Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle.Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-strandedstructure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export ofmRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon10
Gene Wiki entry for U2AF2
|
Genomic Views
for U2AF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the U2AF2 gene promoter:
Max1 E2F-4 E2F-3a E2F-5 ATF-2 E2F-2 E2F-1 E2F c-Jun c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for U2AF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat U2AF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.43U2AF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P056165: view genomic region
(about GC identifiers)
Start:
|
56,165,416 bp from pter |
End:
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56,186,082 bp from pter |
Size:
|
20,667 bases |
Orientation:
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plus strand |
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Proteins
for U2AF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: U2AF2_HUMAN, P26368 (See
protein sequence)Recommended Name: Splicing factor U2AF 65 kDa subunit Size: 475 amino acids; 53501 Da
Subunit: Interacts with U2AF1L4 (By similarity). Heterodimer with U2AF1. Binds unphosphorylated SF1. Interacts withSCAF11 and SNW1. Interacts with ZRSR2/U2AF1-RS2
Subcellular location: Nucleus
6/19 PDB 3D structures from  and Proteopedia  for U2AF2 (see all 19):1JMT (3D)
1O0P (3D)
1OPI (3D)
1U2F (3D)
2G4B (3D)
2HZC (3D)
Secondary accessions: Q96HC5Alternative splicing: 2 isoforms: P26368-1 P26368-2 Explore the universe of human proteins at neXtProt for U2AF2: NX_P26368
Post-translational modifications:
Lysyl-hydroxylation at Lys-15 and Lys-276 affects the mRNA splicing activity of the protein, leading to regulate some,but not all, alternative splicing events1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P26368
U2AF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001012496.1 NP_009210.1
ENSEMBL proteins: ENSP00000388475 ENSP00000307863 ENSP00000468683 ENSP00000468654 ENSP00000466167 ENSP00000466935 Reactome Protein details: P26368
Human Recombinant Protein Products for U2AF2:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
U2AF2 for ontologies About GeneDecksing
U2AF2 Antibody Products:
Assay Products for U2AF2: |
Protein
Domains /
Families
for U2AF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
U2AF2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P26368ProtoNet protein and cluster: P26368 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: U2AF2_HUMAN, P26368Similarity: Belongs to the splicing factor SR familySimilarity: Contains 3 RRM (RNA recognition motif) domains |
Function
for U2AF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: U2AF2_HUMAN, P26368Function: Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle.Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-strandedstructure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export ofmRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon10 Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
U2AF2 for ontologies About GeneDecksing
Phenotypes:
5 GenomeRNAi human phenotypes for U2AF2:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for U2AF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for U2AF2 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): U2AF2 (NM_007279) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for U2AF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat U2AF2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for U2AF2 |
|
Pathways & Interactions
for U2AF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | | | 2 | RNA Polymerase II Transcription Termination | | | 3 | Transcription | | | 4 | Transport of Mature Transcript to Cytoplasm | | | 5 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for U2AF2
5/14 
Reactome Pathways for U2AF2 (see all 14)
1 
Kegg Pathway (Kegg details for U2AF2):
U2AF2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for U2AF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/871 Interacting proteins for U2AF2 (P263681, 2, 3 ENSP000003078634) via UniProtKB, MINT, STRING, and/or I2D (see all 871)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RBM39 | Q144982, 3, ENSP000002533634 | MINT-7945693 MINT-7947479 MINT-8334208 I2D:
score=1 STRING: ENSP00000253363 | | THAP1 | Q9NVV92, 3, ENSP000002542504 | MINT-68219 MINT-7947479 I2D:
score=5 STRING: ENSP00000254250 | | SF3A2 | Q154282, 3, ENSP000002214944 | MINT-5205557 MINT-7947479 I2D:
score=2 STRING: ENSP00000221494 | | SF3B1 | O755332, 3, ENSP000003353214 | MINT-7945693 MINT-7947479 I2D:
score=2 STRING: ENSP00000335321 | | SNW1 | Q135731, 2, ENSP000002615314 | EBI-946034,EBI-632715 MINT-7945693 MINT-7947479 STRING: ENSP00000261531 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000398 | mRNA splicing, via spliceosome |
TAS | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | -- | | GO:0006369 | termination of RNA polymerase II transcription |
TAS | -- | | GO:0006397 | mRNA processing |
TAS | 1538748 | | GO:0006406 | mRNA export from nucleus |
TAS | -- |
U2AF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for U2AF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
U2AF2 for compounds About GeneDecksing
 Browse Tocris compounds for U2AF2
7 Novoseek chemical compound relationships for U2AF2 gene About this table
Search CenterWatch for drugs/clinical trials and news about U2AF2
|
Transcripts
for U2AF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for U2AF2 gene (2 alternative transcripts): NM_001012478.1 NM_007279.2 Unigene Cluster for U2AF2: U2 small nuclear RNA auxiliary factor 2 Hs.528007 [show with all ESTs]Unigene Representative Sequence: NM_00727910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000450554(uc002qlt.3) ENST00000308924(uc002qlu.3) ENST00000588850
ENST00000587196 ENST00000592867 ENST00000590908 ENST00000586832 ENST00000592874
ENST00000590551 ENST00000587275
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for U2AF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for U2AF2 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): U2AF2 (NM_007279) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for U2AF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat U2AF2 |
Additional cDNA sequence: AB451261.1 AB451387.1 AK311672.1 BC008740.2 BC030574.2 X64044.1 18 DOTS entries: DT.316064 DT.102824787 DT.100787781 DT.121432600 DT.86847492 DT.97858884 DT.100015615 DT.100036921 DT.102824788 DT.121432571 DT.121432611 DT.99985196 DT.100036922 DT.121432584 DT.92438055 DT.95071809 DT.121432551 DT.95130294 24/266 AceView cDNA sequences (see all 266): AW007068 AW139814 AA640188 BF063339 AI056452 AI915105 BQ005827 BG333194 BM768292 BE646566 AA404408 BC008740 AA620672 AI750096 BE857957 AI743821 BE463917 AI127369 BF732390 BE466369 AI346788 BM720557 AI807465 BF508525
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for U2AF2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for U2AF2
|
Expression
for U2AF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| U2AF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGGCCTGA
About this image
See U2AF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for U2AF2
SOURCE GeneReport for Unigene cluster: Hs.528007
SABiosciences Custom PCR Arrays for U2AF2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for U2AF2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat U2AF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat U2AF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat U2AF2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for U2AF2 |
Orthologs
for U2AF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for U2AF2 gene from 8/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
U2af21 , 5 |
U2 small nuclear ribonucleoprotein auxiliary factor more1, 5 |
91.3(n)1
100(a)1 |
|
7 (2.93 cM)5
221851 NM_133671.31 NP_598432.21
50621435 |
lizard
(Anolis carolinensis) |
Reptilia |
U2AF26 |
-- |
97(a) |
1 ↔ 1 |
GL343279.1(695345-714243) |
African clawed frog
(Xenopus laevis) |
Amphibia |
u2af2-prov2 |
splicing factor U2AF large chain |
78.6(n) |
|
BC044032.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb73g022 |
wufb73g02 |
78.86(n) |
|
322805 CF347908.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
U2af501 |
U2 small nuclear riboprotein auxiliary factor 50 |
67.49(n)
74.26(a) |
|
32602 NM_057543.4 NP_476891.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
uaf-11 |
Protein UAF-1 |
56.59(n)
62.33(a) |
|
175270 NM_001027796.2 NP_001022967.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G609001 |
Splicing factor U2af large subunit B |
49.49(n)
44.81(a) |
|
842382 NM_104771.3 NP_176287.3 |
rice
(Oryza sativa) |
Liliopsida |
Os.273242 |
Oryza sativa (japonica cultivar-group) isolate 31147 more |
71.75(n) |
|
AK073768.1 |
ENSEMBL Gene Tree for U2AF2 (if available)
TreeFam Gene Tree for U2AF2 (if available) |
Paralogs
for U2AF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for U2AF2 gene
- RBM232 RBM392
U2AF2 for paralogs About GeneDecksing
|
Genomic Variants
for U2AF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for U2AF2 (56165416 - 56186082 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for U2AF2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing U2AF2 |
|
Disorders
/ Diseases
for U2AF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
U2AF2 for disorders About GeneDecksing
OMIM gene information: 191318
OMIM disorders: --
12  diseases for U2AF2: About MalaCardsdna topoisomerase i myoclonus epilepsy progressive myoclonus epilepsy treacher collins syndrome
myoclonus frontotemporal dementia herpes simplex wilms tumor
dementia ataxia immunodeficiency malaria
Export disorders for U2AF2 gene to outside databases
|
Publications
for U2AF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for U2AF2 gene, integrated from 9 sources (see all 156):
(articles sorted by number of sources associating them with U2AF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and domain structure of the mammalian splicing factor U2AF. (PubMed id 1538748)1, 2, 3, 9 Zamore P.D.... Green M.R. (1992)
- A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA. (PubMed id 9237760)1, 2, 9 Tronchere H....Fu X.D. (1997)
- Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PubMed id 19574390)1, 2, 9 Webby C.J....Boettger A. (2009)
- A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer. (PubMed id 11551507)1, 2, 9 Kielkopf C.L.... Burley S.K. (2001)
- Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF(65)). (PubMed id 10449418)1, 2, 9 Ito T.... Yokoyama S. (1999)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. (PubMed id 15009664)1, 2 Wang J....Andreadis A. (2004)
- Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP. (PubMed id 12718882)1, 2 Selenko P.... Sattler M. (2003)
- Large-scale proteomic analysis of the human spliceosome. (PubMed id 12176931)1, 2 Rappsilber J.... Mann M. (2002)
- Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly. (PubMed id 10449420)1, 2 Wang X....Robinson P.J. (1999)
|
External Searches for U2AF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing U2AF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing U2AF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing U2AF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for U2AF2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for U2AF2 gene:
Search GeneIP for patents involving U2AF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for U2AF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for U2AF2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for U2AF2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for U2AF2 | | | OriGene Protein Over-expression Lysate for U2AF2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for U2AF2 | | OriGene 3'-UTR Clone for U2AF2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for U2AF2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for U2AF2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for U2AF2 | | OriGene Custom Protein Services for U2AF2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat U2AF2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing U2AF2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat U2AF2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat U2AF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat U2AF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat U2AF2 |
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| | | | Search Tocris compounds for U2AF2 |
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 | | | U2AF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for U2AF2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for U2AF2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat U2AF2 |
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