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Aliases for U2AF1L4 Gene

Aliases for U2AF1L4 Gene

  • U2 Small Nuclear RNA Auxiliary Factor 1-Like 4 2 3
  • U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like Protein 3 3 4
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like Protein 3 3 4
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like Protein 4 3 4
  • U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like 3 2 3
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like 3 2 3
  • U2 Auxiliary Factor 26 3 4
  • U2AF1-Like Protein 3 3 4
  • U2AF1-Like 4 3 4
  • U2AF1-RS3 3 4
  • U2AF1RS3 3 6
  • U2AF1L3 3 4
  • Splicing Factor U2AF 26 KDa Subunit 3
  • U2AF1L3V1 3
  • U2af26 3

External Ids for U2AF1L4 Gene

Previous HGNC Symbols for U2AF1L4 Gene

  • U2AF1L3

Previous GeneCards Identifiers for U2AF1L4 Gene

  • GC00U914419
  • GC19M040926
  • GC19M036233
  • GC19M032738

Summaries for U2AF1L4 Gene

GeneCards Summary for U2AF1L4 Gene

U2AF1L4 (U2 Small Nuclear RNA Auxiliary Factor 1-Like 4) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is ZRSR1.

UniProtKB/Swiss-Prot for U2AF1L4 Gene

  • RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for U2AF1L4 Gene

Genomics for U2AF1L4 Gene

Regulatory Elements for U2AF1L4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for U2AF1L4 Gene

Start:
35,742,464 bp from pter
End:
35,745,445 bp from pter
Size:
2,982 bases
Orientation:
Minus strand

Genomic View for U2AF1L4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for U2AF1L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for U2AF1L4 Gene

Proteins for U2AF1L4 Gene

  • Protein details for U2AF1L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU68-U2AF4_HUMAN
    Recommended name:
    Splicing factor U2AF 26 kDa subunit
    Protein Accession:
    Q8WU68
    Secondary Accessions:
    • A6NKI8
    • Q56UU3

    Protein attributes for U2AF1L4 Gene

    Size:
    220 amino acids
    Molecular mass:
    25744 Da
    Quaternary structure:
    • Interacts with GFI1, U2AF2 and C1QBP.

    Alternative splice isoforms for U2AF1L4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for U2AF1L4 Gene

Proteomics data for U2AF1L4 Gene at MOPED

Post-translational modifications for U2AF1L4 Gene

  • Ubiquitination at Lys13
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for U2AF1L4 Gene

Domains for U2AF1L4 Gene

Gene Families for U2AF1L4 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for U2AF1L4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WU68

UniProtKB/Swiss-Prot:

U2AF4_HUMAN :
  • Q8WU68
Domain:
  • The second zinc finger in necessary for interaction with GFI1 and for alternative pre-mRNA splicing events.
  • The region 162-220 is essential for the nuclear import of the protein in spite of the absence of a nuclear localization signal (NLS). This region is essential for the interaction with C1QBP, interaction which is required for the nuclear translocation. This region may be involved in the localization in nuclear dot-like structures and it also confers the ability of nucleo-cytoplasmic shuttling.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the splicing factor SR family.
Similarity:
  • Contains 2 C3H1-type zinc fingers.
genes like me logo Genes that share domains with U2AF1L4: view

Function for U2AF1L4 Gene

Molecular function for U2AF1L4 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).

Gene Ontology (GO) - Molecular Function for U2AF1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with U2AF1L4: view

Phenotypes for U2AF1L4 Gene

GenomeRNAi human phenotypes for U2AF1L4:
genes like me logo Genes that share phenotypes with U2AF1L4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for U2AF1L4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for U2AF1L4 Gene

Localization for U2AF1L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for U2AF1L4 Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo-cytoplasmic shuttling. {ECO:0000250 UniProtKB:Q8BGJ9}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for U2AF1L4 Gene COMPARTMENTS Subcellular localization image for U2AF1L4 gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for U2AF1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with U2AF1L4: view

Pathways for U2AF1L4 Gene

SuperPathways for U2AF1L4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for U2AF1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with U2AF1L4: view

No data available for Pathways by source for U2AF1L4 Gene

Transcripts for U2AF1L4 Gene

Unigene Clusters for U2AF1L4 Gene

U2 small nuclear RNA auxiliary factor 1-like 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for U2AF1L4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for U2AF1L4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6: - - -
SP7: - - - - - -
SP8: -
SP9: - -
SP10: - - -
SP11: - - - -
SP12: -
SP13: - -
SP14: -
SP15:

ExUns: 11c · 11d · 11e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for U2AF1L4 Gene

GeneLoc Exon Structure for
U2AF1L4
ECgene alternative splicing isoforms for
U2AF1L4

Expression for U2AF1L4 Gene

mRNA expression in normal human tissues for U2AF1L4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for U2AF1L4 Gene

SOURCE GeneReport for Unigene cluster for U2AF1L4 Gene Hs.351558

mRNA Expression by UniProt/SwissProt for U2AF1L4 Gene

Q8WU68-U2AF4_HUMAN
Tissue specificity: Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes.
genes like me logo Genes that share expressions with U2AF1L4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for U2AF1L4 Gene

Orthologs for U2AF1L4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for U2AF1L4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 51 (a)
OneToMany
U2AF1L4 35
  • 98.71 (n)
  • 97.79 (a)
cow
(Bos Taurus)
Mammalia U2AF1L4 36
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia U2af1l4 16
U2af1l4 36
  • 50 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta U2af38 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uaf-2 36
  • 27 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.4357 35
rice
(Oryza sativa)
Liliopsida Os.12075 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9845 36
  • 45 (a)
OneToMany
Species with no ortholog for U2AF1L4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for U2AF1L4 Gene

ENSEMBL:
Gene Tree for U2AF1L4 (if available)
TreeFam:
Gene Tree for U2AF1L4 (if available)

Paralogs for U2AF1L4 Gene

Paralogs for U2AF1L4 Gene

Selected SIMAP similar genes for U2AF1L4 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for U2AF1L4 Gene

genes like me logo Genes that share paralogs with U2AF1L4: view

Variants for U2AF1L4 Gene

Structural Variations from Database of Genomic Variants (DGV) for U2AF1L4 Gene

Variant ID Type Subtype PubMed ID
dgv3852n71 CNV Loss 21882294
dgv3853n71 CNV Loss 21882294
nsv515536 CNV Loss 19592680

Relevant External Links for U2AF1L4 Gene

HapMap Linkage Disequilibrium report
U2AF1L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for U2AF1L4 Gene

Disorders for U2AF1L4 Gene

No disorders were found for U2AF1L4 Gene.

No data available for UniProtKB/Swiss-Prot for U2AF1L4 Gene

Publications for U2AF1L4 Gene

  1. Characterization of U2AF(6), a splicing factor related to U2AF(35). (PMID: 11739736) Shepard J. … Graveley B.R. (Mol. Cell. Biol. 2002) 2 3
  2. Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. (PMID: 8586425) Kitagawa K. … Mukai T. (Genomics 1995) 2 3
  3. Absence of imprinting in U2AFBPL, a human homologue of the imprinted mouse gene U2afbp-rs. (PMID: 8630064) Pearsall R.S. … Held W.A. (Biochem. Biophys. Res. Commun. 1996) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for U2AF1L4 Gene

Sources for U2AF1L4 Gene

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