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Aliases for U2AF1L4 Gene

Aliases for U2AF1L4 Gene

  • U2 Small Nuclear RNA Auxiliary Factor 1 Like 4 2 3 5
  • U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like Protein 3 3 4
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like Protein 3 3 4
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like Protein 4 3 4
  • U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like 3 2 3
  • U2 Auxiliary Factor 26 3 4
  • U2AF1-Like Protein 3 3 4
  • U2AF1-Like 4 3 4
  • U2AF1-RS3 3 4
  • U2AF1L3 3 4
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like 3 3
  • Splicing Factor U2AF 26 KDa Subunit 3
  • U2AF1L3V1 3
  • U2AF1RS3 3
  • U2af26 3

External Ids for U2AF1L4 Gene

Previous HGNC Symbols for U2AF1L4 Gene

  • U2AF1L3

Previous GeneCards Identifiers for U2AF1L4 Gene

  • GC00U914419
  • GC19M040926
  • GC19M036233
  • GC19M032738
  • GC19M035772
  • GC19M035912
  • GC19M035937
  • GC19M036802
  • GC19M037405

Summaries for U2AF1L4 Gene

GeneCards Summary for U2AF1L4 Gene

U2AF1L4 (U2 Small Nuclear RNA Auxiliary Factor 1 Like 4) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Shigellosis. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is U2AF1.

UniProtKB/Swiss-Prot for U2AF1L4 Gene

  • RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for U2AF1L4 Gene

Genomics for U2AF1L4 Gene

Regulatory Elements for U2AF1L4 Gene

Enhancers for U2AF1L4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G035753 1.4 ENCODE dbSUPER 70.4 -10.8 -10813 6.4 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 U2AF1L4 COX6B1 ZBTB32 ENSG00000267049 GC19M038228 HSPB6
GH19G035743 1.2 ENCODE 71.2 -1.1 -1118 5.9 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 ZNF610 GLIS1 U2AF1L4 TMEM147-AS1 ZNF567 HAUS5 ZNF461 ENSG00000267049 KMT2B UPK1A ZNF529-AS1 ENSG00000268947
GH19G035710 2 FANTOM5 Ensembl ENCODE dbSUPER 42.2 +30.3 30253 10.0 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 TBX21 ZFP41 ZFP82 ZNF529 U2AF1L4 TMEM147-AS1 LINC00665 ZNF461 ZNF567 COX6B1 ZNF792 ZNF529-AS1
GH19G035701 2 FANTOM5 Ensembl ENCODE dbSUPER 41.4 +42.8 42845 1.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZNF416 ZNF143 ZNF548 FOS ZNF567 TMEM147-AS1 U2AF1L4 HAUS5 ZNF792 KMT2B RBM42 COX6B1 ZNF146 LRFN3
GH19G035739 1.1 ENCODE 71.2 +4.0 4017 3.9 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B U2AF1L4 COX6B1 TMEM147-AS1 ENSG00000267049 ENSG00000268947 UPK1A GC19P036333 IGFLR1 PIR61488
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around U2AF1L4 on UCSC Golden Path with GeneCards custom track

Promoters for U2AF1L4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109059 -155 1601 HDGF CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 CBX5 ZNF207 ZNF143
ENSR00000109059 -158 1601 HDGF CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 CBX5 ZNF207 ZNF143

Genomic Location for U2AF1L4 Gene

Chromosome:
19
Start:
35,742,464 bp from pter
End:
35,745,445 bp from pter
Size:
2,982 bases
Orientation:
Minus strand

Genomic View for U2AF1L4 Gene

Genes around U2AF1L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
U2AF1L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for U2AF1L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for U2AF1L4 Gene

Proteins for U2AF1L4 Gene

  • Protein details for U2AF1L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU68-U2AF4_HUMAN
    Recommended name:
    Splicing factor U2AF 26 kDa subunit
    Protein Accession:
    Q8WU68
    Secondary Accessions:
    • A6NKI8
    • Q56UU3

    Protein attributes for U2AF1L4 Gene

    Size:
    220 amino acids
    Molecular mass:
    25744 Da
    Quaternary structure:
    • Interacts with GFI1, U2AF2 and C1QBP.

    Alternative splice isoforms for U2AF1L4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for U2AF1L4 Gene

Post-translational modifications for U2AF1L4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for U2AF1L4 Gene

Domains & Families for U2AF1L4 Gene

Gene Families for U2AF1L4 Gene

Suggested Antigen Peptide Sequences for U2AF1L4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WU68

UniProtKB/Swiss-Prot:

U2AF4_HUMAN :
  • The second zinc finger in necessary for interaction with GFI1 and for alternative pre-mRNA splicing events.
  • Belongs to the splicing factor SR family.
Domain:
  • The second zinc finger in necessary for interaction with GFI1 and for alternative pre-mRNA splicing events.
  • The region 162-220 is essential for the nuclear import of the protein in spite of the absence of a nuclear localization signal (NLS). This region is essential for the interaction with C1QBP, interaction which is required for the nuclear translocation. This region may be involved in the localization in nuclear dot-like structures and it also confers the ability of nucleo-cytoplasmic shuttling.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with U2AF1L4: view

Function for U2AF1L4 Gene

Molecular function for U2AF1L4 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).

Gene Ontology (GO) - Molecular Function for U2AF1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0030628 pre-mRNA 3-splice site binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with U2AF1L4: view
genes like me logo Genes that share phenotypes with U2AF1L4: view

Animal Model Products

CRISPR Products

miRNA for U2AF1L4 Gene

miRTarBase miRNAs that target U2AF1L4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for U2AF1L4 Gene

Localization for U2AF1L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for U2AF1L4 Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo-cytoplasmic shuttling. {ECO:0000250 UniProtKB:Q8BGJ9}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for U2AF1L4 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for U2AF1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IBA,IEA --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with U2AF1L4: view

Pathways & Interactions for U2AF1L4 Gene

genes like me logo Genes that share pathways with U2AF1L4: view

Pathways by source for U2AF1L4 Gene

Gene Ontology (GO) - Biological Process for U2AF1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing IEA --
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with U2AF1L4: view

No data available for SIGNOR curated interactions for U2AF1L4 Gene

Transcripts for U2AF1L4 Gene

Unigene Clusters for U2AF1L4 Gene

U2 small nuclear RNA auxiliary factor 1-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for U2AF1L4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6: - - -
SP7: - - - - - -
SP8: -
SP9: - -
SP10: - - -
SP11: - - - -
SP12: -
SP13: - -
SP14: -
SP15:

ExUns: 11c · 11d · 11e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for U2AF1L4 Gene

GeneLoc Exon Structure for
U2AF1L4
ECgene alternative splicing isoforms for
U2AF1L4

Expression for U2AF1L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for U2AF1L4 Gene

Protein differential expression in normal tissues from HIPED for U2AF1L4 Gene

This gene is overexpressed in Urine (65.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for U2AF1L4 Gene



Protein tissue co-expression partners for U2AF1L4 Gene

NURSA nuclear receptor signaling pathways regulating expression of U2AF1L4 Gene:

U2AF1L4

SOURCE GeneReport for Unigene cluster for U2AF1L4 Gene:

Hs.351558

mRNA Expression by UniProt/SwissProt for U2AF1L4 Gene:

Q8WU68-U2AF4_HUMAN
Tissue specificity: Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for U2AF1L4 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with U2AF1L4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for U2AF1L4 Gene

Orthologs for U2AF1L4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for U2AF1L4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U2AF1L4 34
  • 98.71 (n)
-- 35
  • 51 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia U2af1l4 35
  • 50 (a)
OneToMany
cow
(Bos Taurus)
Mammalia U2AF1L4 35
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta U2af38 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uaf-2 35
  • 27 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.12075 34
corn
(Zea mays)
Liliopsida Zm.4357 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9845 35
  • 45 (a)
OneToMany
Species where no ortholog for U2AF1L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for U2AF1L4 Gene

ENSEMBL:
Gene Tree for U2AF1L4 (if available)
TreeFam:
Gene Tree for U2AF1L4 (if available)

Paralogs for U2AF1L4 Gene

Paralogs for U2AF1L4 Gene

Pseudogenes.org Pseudogenes for U2AF1L4 Gene

genes like me logo Genes that share paralogs with U2AF1L4: view

Variants for U2AF1L4 Gene

Sequence variations from dbSNP and Humsavar for U2AF1L4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001123270 -- 35,746,666(+) GAGAG(A/C)AGCCG intron-variant, upstream-variant-2KB
rs1001532039 -- 35,746,250(+) AGATT(C/T)CTGGA intron-variant, upstream-variant-2KB
rs1002437820 -- 35,746,106(+) CGAAC(A/G)CCGAC intron-variant, upstream-variant-2KB
rs1003090496 -- 35,743,423(+) TGGTG(A/G)CTCAC intron-variant, upstream-variant-2KB
rs1003120808 -- 35,744,197(+) CAGGG(A/G)ACTCA intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for U2AF1L4 Gene

Variant ID Type Subtype PubMed ID
nsv515536 CNV loss 19592680
nsv579422 CNV loss 21841781
nsv579423 CNV loss 21841781

Variation tolerance for U2AF1L4 Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for U2AF1L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
U2AF1L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for U2AF1L4 Gene

Disorders for U2AF1L4 Gene

Relevant External Links for U2AF1L4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
U2AF1L4

No disorders were found for U2AF1L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for U2AF1L4 Gene

Publications for U2AF1L4 Gene

  1. Characterization of U2AF(6), a splicing factor related to U2AF(35). (PMID: 11739736) Shepard J. … Graveley B.R. (Mol. Cell. Biol. 2002) 2 3 64
  2. Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. (PMID: 8586425) Kitagawa K. … Mukai T. (Genomics 1995) 2 3 64
  3. [Cytokine-mediated regulation of expression of Gfi1 and U2afll4 genes activated by T-cells with different differentiation status in vitro]. (PMID: 27143377) Yurova K.A. … Litvinova L.S. (Biomed Khim 2016) 3 64
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3 64
  5. Human PSENEN and U2AF1L4 genes are concertedly regulated by a genuine bidirectional promoter. (PMID: 23246698) Didych D.A. … Sverdlov E.D. (Gene 2013) 3 64

Products for U2AF1L4 Gene

Sources for U2AF1L4 Gene

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