V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

U2AF1 Gene

protein-coding GIFtS: 62

GC21M043386

U2 small nuclear RNA auxiliary factor 1
(Previous names: U2(RNU2) small nuclear RNA auxiliary factor binding protein, U2(RNU2) small nuclear RNA auxiliary factor 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: U2AFBP)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
DKFZp313J1712 ^²
FP793 ^²
RN ^¹, ²
RNU2AF1 ^¹, ²
U2AF35 ^¹, ², ³
U2AFBP ^², ³

Descriptions
U2 auxiliary factor 35 kDa subunit ^³
U2 small nuclear RNA auxiliary factor 1 ^²
U2 small nuclear RNA auxillary factor 1 ^²
U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit ^²
U2 snRNP auxiliary factor small subunit ^², ³
U2(RNU2) small nuclear RNA auxiliary factor 1 ^¹, ²
U2(RNU2) small nuclear RNA auxiliary factor binding protein ^¹, ²
human U2 snRNP auxiliary factor small subunit ⁹
splicing factor U2AF 35kDa subunit ^²

External Ids
HGNC: 12453¹
Entrez Gene: 7307²
UniProtKB: Q01081³
Ensembl: ENSG00000160201⁷

Search outside databases for aliases for U2AF1 gene

Previous GC identifers: GC21M041060 GC21M043407

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for U2AF1:

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a

large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the

pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both

constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the

large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants

encoding different isoforms have been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: U2AF1_HUMAN, Q01081

Function: Plays a critical role in both constitutive and enhancer-dependent splicing by mediating

protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site

selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and

proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer

complex to recruit it to the adjacent intron

Gene Wiki entry for U2AF1 (U2_small_nuclear_RNA_auxiliary_factor_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

U2AF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M043386:	GeneLoc	Nature:405,311-319
Start:	43,386,135 bp from pter	30,060,393 bp from centromere
End:	43,400,757 bp from pter	30,074,960 bp from centromere
Size:	14,623 bases	14,568 bases
Orientation:	minus strand	minus strand

RefSeq DNA sequence:

NC_000021.7 NT_030188.4

Whole chromosome sequencing:
cDNA sequence:	M96982
genomic clones:	KB2007G4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: U2AF1_HUMAN, Q01081 (See protein sequence)

Recommended Name: Splicing factor U2AF 35 kDa subunit

Size: 240 amino acids; 27872 Da

Subunit: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29,

CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1,

HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604,

LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6,

PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2,

SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2,

SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Heterodimer with U2AF2. Interacts with

ZRANB2

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1JMT (3D)

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001020374.1 NP_001020375.1 NP_006749.1

ENSEMBL proteins:

ENSP00000381205 ENSP00000369629 ENSP00000291552

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (U2AF35)
	Human Recombinant Proteins from Abnova (U2AF1)

OriGene Purified Recombinant Human Protein: U2AF1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005681	spliceosome	IDA	9731529
GO:0015030	Cajal body	TAS	1388271

About this table

Antibodies for U2AF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (U2AF35), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (U2AF1)
	Novus Biologicals Antibody for U2AF1

Assays for U2AF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q01081

ProtoNet protein and cluster: Q01081

3 Blocks protein families:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB000571 Zn-finger

IPB009145 U2 auxiliary factor small subunit signature

UniProtKB/Swiss-Prot: U2AF1_HUMAN, Q01081

Domain: The C-terminal SR-rich domain is required for interactions with SR proteins and the

splicing regulators TRA and TRA2, and the N-terminal domain is required for formation of the

U2AF1/U2AF2 heterodimer

Similarity: Belongs to the splicing factor SR family

Similarity: Contains 2 C3H1-type zinc fingers

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (U2AF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (U2AF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_006758

Applied Biosystems Silencer® siRNAs for U2AF1

Sigma-Aldrich siRNA for U2AF1

Sigma-Aldrich shRNA for U2AF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for U2AF1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001025203
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001025203
untagged cDNA clones in CMV expression vector (see all 4): AK098266

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001025203

UniProtKB/Swiss-Prot: U2AF1_HUMAN, Q01081

Function: Plays a critical role in both constitutive and enhancer-dependent splicing by mediating

protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site

selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and

proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer

complex to recruit it to the adjacent intron

Genatlas biochemistry entry for U2AF1:

U2 (RNU2) small nuclear RNA auxiliary factor,small subunit,1,35kDa

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	11551507 15652350
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for U2AF1

5/119 Interacting proteins for U2AF1 (ENSP00000369629³ Q01081^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 119 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SF3A2	Q15428²	STRING (score=.989) MINT-5205566
CIR	Q86X95¹	EBI-632461, EBI-627102
U2AF2	P26368¹	EBI-632461, EBI-742339
SF3A3	ENSP00000362110³	STRING (score=.982)
NXF1	ENSP00000294172³	STRING (score=.971)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	nuclear mRNA splicing, via spliceosome	IC	9731529
GO:0008380	RNA splicing	TAS	1388271

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for U2AF1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (U2AF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (U2AF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_006758

Sigma-Aldrich siRNA for U2AF1

Sigma-Aldrich shRNA for U2AF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001025203 NM_001025204 NM_006758

REFSEQ mRNAs for U2AF1 gene (3 alternative transcripts):

NM_001025203.1 NM_001025204.1 NM_006758.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001025203 NM_001025204 NM_006758

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001025203
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001025203
                                 untagged cDNA clones in CMV expression vector (see all 4): AK098266

Additional cDNA sequence:

AB451244.1 AJ627978.1 AK307560.1 BC001177.1 BC001923.1 BC005915.1 CR606196.1 CR622357.1

M96982.1

19 DOTS entries:

DT.446719 DT.446720 DT.97859339 DT.97769413 DT.65285770 DT.91755804 DT.97859340 DT.121140803

DT.100814480 DT.100888233 DT.121140765 DT.91770412 DT.97783922 DT.102831722 DT.95246274 DT.95276156

DT.100702294 DT.91652583 DT.91770413

24/333 AceView cDNA sequences (see all 333 ):

BE043061 CB121342 AI762575 BI089424 AW054922 BU786275 AU117277 AI418754

BI047747 BM451145 BX331525 BQ068770 AA306069 CB110007 BM918437 BM505425

AL522322 AW009580 BM827141 CB114008 BI870370 AA807201 AA580692 CB110063

highest scoring ESTs for U2AF1:

M96982 AA070540 AA172318 AA315164 AL528326 AL528327 BC001177 BC001923 BC005915 BE207111

Unigene Cluster for U2AF1:

U2 small nuclear RNA auxiliary factor 1

Hs.365116 [show with all ESTs]

Unigene Representative Sequence: BM916584

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for U2AF1 (see all 6 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c	^	9
SP1:									-				-				-
SP2:																									-
SP3:			-		-				-
SP4:					-				-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for U2AF1

3 Ensembl transcripts including schematic representations:

ENST00000398137 ENST00000380276 ENST00000291552

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

U2AF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for U2AF1

¹ / ² / ³

9 probe-sets matching U2AF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
78888_at²^{, 3}	U95-E	1	1.00	1.00	0.93	0.53	AI090513	0.60	1.00	0.82	1
68830_at²^{, 3}	U95-E	1	1.00	1.00	0.37	1.05	AI762575	0.60	1.00	0.82	1
36517_at²^{, 3}	U95-A	2	1.00	0.91	0.41	1.44	M96982	1.00	1.00	1.00	1
232141_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU144161	0.40	1.00	0.76	1
202858_at²^{, 3}	U133-A	3	1.00	0.77	--	--	NM_006758	0.60	1.00	0.82	1
231904_at²^{, 3}	U133-B	1	0.64	1.00	--	--	AU122448	0.40	1.00	0.76	1
232141_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202858_at²	U133Plus2	3	1.00	0.77	--	--	--	--	--	--	--
231904_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

GeneDecks U2AF1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCATTTTTAC

SOURCE GeneReport for Unigene cluster: Hs.365116
Expression variation in blood from EXPOLDB for U2AF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for U2AF1 gene from 5/22 species (see all 22 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	U2AF1¹	--	U2 small nuclear RNA auxiliary factor 1	87.48(n) 95.63(a)	478422 XM_535599.2 XP_535599.2
chimpanzee (Pan troglodytes)	U2AF1¹	--	U2 small nuclear RNA auxiliary factor 1	96.53(n) 97.08(a)	737227 XM_001137466.1 XP_001137466.1
cow (Bos taurus)	U2AF1¹	--	U2 small nuclear RNA auxiliary factor 1	92.41(n) 100(a)	512680 XM_875504.2 XP_880597.1
mouse (Mus musculus)	U2af1⁵ ENSMUSG00000068141¹	17⁵	U2 small nuclear ribonucleoprotein auxiliary factor more⁵ predicted gene, ENSMUSG00000068141¹	87.03(n)¹ 96.65(a)¹	100040029¹ XM_001474531.1¹ XP_001474581.1¹ AA117854⁵ AC084065⁵ (see all 18)
zebrafish (Danio rerio)	u2af1²	--	U2(RNU2) small nuclear RNA auxillary factor 1	79.54(n)	192328 AF506202.1

About this table Species with no ortholog for U2AF1

ENSEMBL Gene Tree for U2AF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for U2AF1 gene

ZRSR2² ZRSR1² U2AF1L4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/97 NCBI SNPs in U2AF1 are shown (see all 97 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs11700839^1,2	A,C	43401475(-)	`CTATGC/GGGCTT`	3	--	ng3¹		0	--	--	--	--
	rs11700879^1,2	C,F	43401651(+)	`CACAGG/ATGGAG`	3	--	ng3¹		2		MN EA	356
	rs2839635^1,2	A,C,F,H,O	43391760(+)	`ATATGC/GAAAAC`	3	--	int¹		5		NA EU EA WA	420
	rs2839634^1,2	A,C,F,H,O	43388754(+)	`ATACAT/CTACAA`	3	--	int¹		17		NA EA EU WA	1417
	rs2255829^1,2	A,C,F,H,O	43397969(+)	`GAAAAC/GACCGG`	3	--	int¹		5		EU EA WA NA	431
	rs4920039^1,2	A,C,F,H	43388415(+)	`GCAGCT/CGGTAG`	3	--	int¹		4		EU EA WA	408
	rs4920040^1,2	A,C,F,H	43388573(+)	`GGCCCT/CGGCAC`	3	--	int¹		3		EA WA	298
	rs1970689^1,2	A,C,F,H	43400420(+)	`ATTCTG/CCCCGC`	3	--	int¹		4		EU EA WA	414
	rs1888523^1,2	A,C,F,H	43398288(+)	`TGACCG/AAACCC`	3	--	int¹		9		EU EA WA NA	2278
	rs11910456^1,2	A,C,F,H	43395098(+)	`ATTTAC/TACTTT`	3	--	int¹		7		NA EU EA WA	558

About this table

HapMap Linkage Disequilibrium images for U2AF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 191317

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/62 PubMed articles for U2AF1 gene (see all 62 ):

The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. (PubMed id 8647433)^{1, 3, 4} Zuo P. and Maniatis T. (1996)
Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit. (PubMed id 1388271)^{1, 3, 4} Zhang M.... Green M.R. (1992)
The gene for human U2 snRNP auxiliary factor small 35-kDa subunit (U2AF1) maps to the progressive myoclonus epilepsy (EPM1) critical region on chromosome 21q22.3. (PubMed id 8660980)^{1, 2, 3} Lalioti M.D....Antonarakis S.E. (1996)
A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer. (PubMed id 11551507)^{1, 3, 4} Kielkopf C.L.... Burley S.K. (2001)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)^{3, 4} Jurica M.S.... Moore M.J. (2002)
ZNF265 -- a novel spliceosomal protein able to induce alternative splicing. (PubMed id 11448987)^{3, 4} Adams D.J....Rasko J.E.J. (2001)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{3, 4} Hattori M....Yaspo M.L. (2000)
Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5. (PubMed id 7956352)^{2, 3} Kalcheva I....Takagi N. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7307	HGNC: 12453	AceView: U2AF1	Ensembl:ENSG00000160201	euGenes: HUgn7307
ECgene: U2AF1	H-InvDB: U2AF1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for U2AF1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for U2AF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for U2AF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for U2AF1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for U2AF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (U2AF1)
	Antibodies (U2AF1)
	Chimera RNAi (U2AF1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (U2AF35)
	Antibodies (U2AF35)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for U2AF1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for U2AF1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
U2AF1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

U2AF1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for U2AF1

Summaries
for U2AF1

Genomic Location
for U2AF1

Proteins
for U2AF1

Protein Domains/
Families
for U2AF1

Gene Function
for U2AF1

Pathways & Interactions
for U2AF1

Drugs & Compounds
for U2AF1

Transcripts
for U2AF1

Expression
for U2AF1

Orthologs
for U2AF1

Paralogs
for U2AF1

SNPs/Variants
for U2AF1

Disorders & Mutations
for U2AF1

Medical News
for U2AF1

Publications
for U2AF1

Search for U2AF1

Genome Databases showing U2AF1

Other Databases showing U2AF1

Specialized Databases showing U2AF1

Licensable Technologies
for U2AF1

Services
for U2AF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

U2AF1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor U2AF1

Summariesfor U2AF1

Genomic Locationfor U2AF1

Proteinsfor U2AF1

Protein Domains/Familiesfor U2AF1

Gene Functionfor U2AF1

Pathways & Interactionsfor U2AF1

Drugs & Compoundsfor U2AF1

Transcriptsfor U2AF1

Expression for U2AF1

Orthologsfor U2AF1

Paralogsfor U2AF1

SNPs/Variantsfor U2AF1

Disorders & Mutationsfor U2AF1

Medical Newsfor U2AF1

Publicationsfor U2AF1

Search for U2AF1

Genome Databases showing U2AF1

Other Databases showing U2AF1

Specialized Databases showing U2AF1

Licensable Technologiesfor U2AF1

Servicesfor U2AF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for U2AF1

Summaries
for U2AF1

Genomic Location
for U2AF1

Proteins
for U2AF1

Protein Domains/
Families
for U2AF1

Gene Function
for U2AF1

Pathways & Interactions
for U2AF1

Drugs & Compounds
for U2AF1

Transcripts
for U2AF1

Expression
for U2AF1

Orthologs
for U2AF1

Paralogs
for U2AF1

SNPs/Variants
for U2AF1

Disorders & Mutations
for U2AF1

Medical News
for U2AF1

Publications
for U2AF1

Licensable Technologies
for U2AF1

Services
for U2AF1