Aliases for U2AF1 Gene
- U2 Small Nuclear RNA Auxiliary Factor 1 2 3 4
- U2(RNU2) Small Nuclear RNA Auxiliary Factor Binding Protein 2 3
- U2 SnRNP Auxiliary Factor Small Subunit 3 4
- U2AFBP 3 4
- U2AF35 3 4
- U2 Small Nuclear Ribonucleoprotein Auxillary Factor, 35-KD Subunit 3
- U2(RNU2) Small Nuclear RNA Auxiliary Factor 1 2
- U2 Small Nuclear RNA Auxillary Factor 1 3
External Ids for U2AF1 Gene
Previous Symbols for U2AF1 Gene
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for U2AF1 Gene
U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1) is a Protein Coding gene. Among its related pathways are Salmonella infection (KEGG) and Gene Expression. GO annotations related to this gene include RNA binding and RS domain binding. An important paralog of this gene is ZRSR1.
UniProtKB/Swiss-Prot for U2AF1 Gene
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.