Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TYW5 Gene

Aliases for TYW5 Gene

  • TRNA-YW Synthesizing Protein 5 2 3 5
  • TRNA(Phe) (7-(3-Amino-3-Carboxypropyl)Wyosine(37)-C(2))-Hydroxylase 3 4
  • C2orf60 3 4
  • HTYW5 3 4
  • JmjC Domain-Containing Protein C2orf60 3
  • Chromosome 2 Open Reading Frame 60 2
  • TRNA YW-Synthesizing Enzyme 5 3
  • EC 1.14.11.42 4

External Ids for TYW5 Gene

Previous HGNC Symbols for TYW5 Gene

  • C2orf60

Previous GeneCards Identifiers for TYW5 Gene

  • GC02M200794

Summaries for TYW5 Gene

GeneCards Summary for TYW5 Gene

TYW5 (TRNA-YW Synthesizing Protein 5) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include protein homodimerization activity and tRNA binding. An important paralog of this gene is HSPBAP1.

UniProtKB/Swiss-Prot for TYW5 Gene

  • tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYW5 Gene

Genomics for TYW5 Gene

Regulatory Elements for TYW5 Gene

Promoters for TYW5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TYW5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TYW5 Gene

Chromosome:
2
Start:
199,928,911 bp from pter
End:
199,955,736 bp from pter
Size:
26,826 bases
Orientation:
Minus strand

Genomic View for TYW5 Gene

Genes around TYW5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYW5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYW5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYW5 Gene

Proteins for TYW5 Gene

  • Protein details for TYW5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RUC4-TYW5_HUMAN
    Recommended name:
    tRNA wybutosine-synthesizing protein 5
    Protein Accession:
    A2RUC4
    Secondary Accessions:
    • B2RNE3
    • Q8N1R2

    Protein attributes for TYW5 Gene

    Size:
    315 amino acids
    Molecular mass:
    36548 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH63502.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TYW5 Gene

    Alternative splice isoforms for TYW5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TYW5 Gene

Proteomics data for TYW5 Gene at MOPED

Post-translational modifications for TYW5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TYW5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TYW5 Gene

Domains & Families for TYW5 Gene

Protein Domains for TYW5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TYW5 Gene

Graphical View of Domain Structure for InterPro Entry

A2RUC4

UniProtKB/Swiss-Prot:

TYW5_HUMAN :
  • Contains 1 JmjC domain.
  • Belongs to the TYW5 family.
Domain:
  • Contains 1 JmjC domain.
Family:
  • Belongs to the TYW5 family.
genes like me logo Genes that share domains with TYW5: view

No data available for Gene Families for TYW5 Gene

Function for TYW5 Gene

Molecular function for TYW5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2).
UniProtKB/Swiss-Prot Function:
tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.

Enzyme Numbers (IUBMB) for TYW5 Gene

genes like me logo Genes that share phenotypes with TYW5: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TYW5 Gene

Localization for TYW5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TYW5 Gene COMPARTMENTS Subcellular localization image for TYW5 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TYW5 Gene

Pathways & Interactions for TYW5 Gene

genes like me logo Genes that share pathways with TYW5: view

UniProtKB/Swiss-Prot A2RUC4-TYW5_HUMAN

  • Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis.

Interacting Proteins for TYW5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000346627%0d%0a9606.ENSP00000272091%0d%0a
Selected Interacting proteins: ENSP00000346627 for TYW5 Gene via STRING

Symbol External ID(s) Details
SDE2

Gene Ontology (GO) - Biological Process for TYW5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS --
genes like me logo Genes that share ontologies with TYW5: view

No data available for SIGNOR curated interactions for TYW5 Gene

Drugs & Compounds for TYW5 Gene

No Compound Related Data Available

Transcripts for TYW5 Gene

Unigene Clusters for TYW5 Gene

TRNA-yW synthesizing protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TYW5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for TYW5 Gene

GeneLoc Exon Structure for
TYW5
ECgene alternative splicing isoforms for
TYW5

Expression for TYW5 Gene

mRNA expression in normal human tissues for TYW5 Gene

Protein differential expression in normal tissues from HIPED for TYW5 Gene

This gene is overexpressed in Heart (33.7), Skin (11.0), and Retina (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TYW5 Gene



SOURCE GeneReport for Unigene cluster for TYW5 Gene Hs.204619

genes like me logo Genes that share expression patterns with TYW5: view

Protein tissue co-expression partners for TYW5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TYW5 Gene

Orthologs for TYW5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TYW5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TYW5 35
  • 90.9 (n)
  • 92.38 (a)
TYW5 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TYW5 35
  • 92.38 (n)
  • 94.29 (a)
TYW5 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tyw5 35
  • 86.88 (n)
  • 89.21 (a)
Tyw5 16
Tyw5 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TYW5 35
  • 99.79 (n)
  • 100 (a)
TYW5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tyw5 35
  • 85.82 (n)
  • 88.25 (a)
oppossum
(Monodelphis domestica)
Mammalia TYW5 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TYW5 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TYW5 35
  • 77.2 (n)
  • 77.52 (a)
TYW5 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TYW5 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tyw5 35
  • 70.73 (n)
  • 76.28 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14896 35
tyw5 35
  • 62.68 (n)
  • 66.99 (a)
tyw5 36
  • 64 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToOne
Species with no ortholog for TYW5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TYW5 Gene

ENSEMBL:
Gene Tree for TYW5 (if available)
TreeFam:
Gene Tree for TYW5 (if available)

Paralogs for TYW5 Gene

Paralogs for TYW5 Gene

Pseudogenes.org Pseudogenes for TYW5 Gene

genes like me logo Genes that share paralogs with TYW5: view

Variants for TYW5 Gene

Sequence variations from dbSNP and Humsavar for TYW5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10497844 - 199,948,403(+) TTGGC(C/T)TAGGT intron-variant, nc-transcript-variant, reference, missense
rs166846 -- 199,942,131(+) gtgca(A/G)tctcg intron-variant
rs281762 -- 199,934,478(-) GCAAC(C/G)AACGT intron-variant
rs281763 -- 199,930,147(-) ATACA(A/G)AGAAT nc-transcript-variant, utr-variant-3-prime
rs281769 -- 199,944,986(+) TAACC(C/T)GATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TYW5 Gene

Variant ID Type Subtype PubMed ID
nsv875704 CNV Gain 21882294
nsv834510 CNV Loss 17160897

Variation tolerance for TYW5 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.46; 64.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TYW5 Gene

HapMap Linkage Disequilibrium report
TYW5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYW5 Gene

Disorders for TYW5 Gene

Relevant External Links for TYW5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TYW5

No disorders were found for TYW5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TYW5 Gene

Publications for TYW5 Gene

  1. Expanding role of the jumonji C domain as an RNA hydroxylase. (PMID: 20739293) Noma A. … Suzuki T. (J. Biol. Chem. 2010) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3
  4. Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. (PMID: 20972222) Kato M. … Nureki O. (Nucleic Acids Res. 2011) 3
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3

Products for TYW5 Gene

Sources for TYW5 Gene

Back to Top

Content