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TYW5 Gene

protein-coding   GIFtS: 40
GCID: GC02M200794

TRNA-YW Synthesizing Protein 5

(Previous name: chromosome 2 open reading frame 60)
(Previous symbol: C2orf60)
  Search for TYW5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRNA-YW Synthesizing Protein 51 2     JmjC Domain-Containing Protein C2orf602
C2orf601 2 3     TRNA Wybutosine-Synthesizing Protein 52
hTYW52 3     TRNA YW-Synthesizing Enzyme 52
TRNA(Phe) (7-(3-Amino-3-Carboxypropyl)Wyosine(37)-C(2))-Hydroxylase2 3     EC 1.14.11.423
Chromosome 2 Open Reading Frame 601     

External Ids:    HGNC: 267541   Entrez Gene: 1294502   Ensembl: ENSG000001629717   UniProtKB: A2RUC43   

Export aliases for TYW5 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TYW5 Gene:
TYW5 (tRNA-yW synthesizing protein 5) is a protein-coding gene. GO annotations related to this gene include tRNA binding and protein homodimerization activity. An important paralog of this gene is KDM8.

UniProtKB/Swiss-Prot: TYW5_HUMAN, A2RUC4
Function: tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper
modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic
phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified
hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a
derivative of wybutosine found in higher eukaryotes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TYW5
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TYW5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TYW5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

TYW5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TYW5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M200794:  view genomic region     (about GC identifiers)

Start:
200,793,634 bp from pter      End:
200,820,459 bp from pter
Size:
26,826 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TYW5_HUMAN, A2RUC4 (See protein sequence)
Recommended Name: tRNA wybutosine-synthesizing protein 5  
Size: 315 amino acids; 36548 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subunit: Homodimer
Sequence caution: Sequence=AAH63502.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for TYW5:
3AL5 (3D)        3AL6 (3D)    
Secondary accessions: B2RNE3 Q8N1R2
Alternative splicing: 2 isoforms:  A2RUC4-1   A2RUC4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TYW5: NX_A2RUC4

Explore proteomics data for TYW5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TYW5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001034782.1  
    ENSEMBL proteins: 
     ENSP00000346627   ENSP00000420024   ENSP00000398447  

    TYW5 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TYW5
    Cloud-Clone Corp. Proteins for TYW5

     
    Search eBioscience for Proteins for TYW5 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry A2RUC4

    ProtoNet protein and cluster: A2RUC4

    UniProtKB/Swiss-Prot: TYW5_HUMAN, A2RUC4
    Similarity: Belongs to the TYW5 family
    Similarity: Contains 1 JmjC domain


    Find genes that share domains with TYW5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYW5_HUMAN, A2RUC4
    Function: tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper
    modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic
    phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified
    hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a
    derivative of wybutosine found in higher eukaryotes
    Catalytic activity: 7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) =
    7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2)

         Enzyme Number (IUBMB): EC 1.14.11.421

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IDA--
    GO:0005506iron ion binding IDA--
    GO:0005515protein binding ----
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA--
    GO:0042803protein homodimerization activity IDA--
         
    Find genes that share ontologies with TYW5           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TYW5
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    miRNA
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    miRTarBase miRNAs that target TYW5:
    hsa-mir-93-5p (MIRT028067)

    Block miRNA regulation of human, mouse, rat TYW5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TYW5 (see all 16):
    hsa-miR-21* hsa-miR-579 hsa-miR-3194-5p hsa-miR-134 hsa-miR-29c hsa-miR-29a hsa-miR-4314 hsa-miR-511
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TYW5

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TYW5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYW5

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYW5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: TYW5_HUMAN, A2RUC4
    Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TYW5
    Interactions:

        Search GeneGlobe Interaction Network for TYW5

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031591wybutosine biosynthetic process IDA--

    Find genes that share ontologies with TYW5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TYW5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TYW5 gene (2 alternative transcripts): 
    NM_152382.1  NM_001039693.2  

    Unigene Cluster for TYW5:

    TRNA-yW synthesizing protein 5
    Hs.204619  [show with all ESTs]
    Unigene Representative Sequence: NM_001039693
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354611(uc002uvi.4) ENST00000483328(uc002uvj.4 uc002uvk.4 uc010fss.3)
    ENST00000452512 ENST00000441832 ENST00000493181(uc002uvl.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat TYW5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TYW5 (see all 16):
    hsa-miR-21* hsa-miR-579 hsa-miR-3194-5p hsa-miR-134 hsa-miR-29c hsa-miR-29a hsa-miR-4314 hsa-miR-511
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TYW5
      QuantiFast Probe-based Assays in human, mouse, rat TYW5

    Additional mRNA sequence: 

    AK095272.1 AK293064.1 AK298977.1 BC025758.1 BC063502.1 BC132835.1 BC136837.1 BC144420.1 
    BX647677.1 NR_004862.1 

    8 DOTS entries:

    DT.308338  DT.120941107  DT.211263  DT.211265  DT.454709  DT.100710886  DT.100714615  DT.111614 

    Selected AceView cDNA sequences (see all 85):

    AA700050 BF438043 CB305779 BX107886 AI052737 CB529067 AI057373 BC063502 
    AI868437 T40732 BQ424547 AA632314 BI769592 AA402102 AI685332 BX094248 
    BM721903 NM_152382 CD642835 BQ920982 AA209186 AI350630 BX470734 AK095272 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TYW5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                          -     -                       -                           
    SP2:                          -     -                       -     -                     
    SP3:                                -                       -                           
    SP4:                          -     -                                                   
    SP5:                                                                                    


    ECgene alternative splicing isoforms for TYW5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TYW5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGAAACCTT
    TYW5 Expression
    About this image

    TYW5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TYW5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.204619
        Custom PCR Arrays for TYW5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYW5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TYW5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tyw51 , 5 RIKEN cDNA 1110034B05 gene5
    tRNA-yW synthesizing protein 51
    86.88(n)1
    89.21(a)1
      1 (28.78 cM)5
    687361  NM_001037742.21  NP_001032831.21 
     573882375 
    chicken
    (Gallus gallus)
    Aves TYW51 tRNA-yW synthesizing protein 5 77.2(n)
    77.52(a)
      424065  XM_421921.3  XP_421921.2 
    lizard
    (Anolis carolinensis)
    Reptilia TYW56
    tRNA-yW synthesizing protein 5
    78(a)
    1 ↔ 1
    1(117570092-117588649)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ077044.12   -- 76.74(n)    BJ077044.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.148962 Transcribed sequence with weak similarity to protein more 72.96(n)    BM035027.1 


    ENSEMBL Gene Tree for TYW5 (if available)
    TreeFam Gene Tree for TYW5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TYW5 gene
    KDM82  HSPBAP12  HIF1AN2  

    Find genes that share paralogs with TYW5           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TYW5
    PGOHUM00000238264


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TYW5 (see all 389)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs168320511,2
    C,F,H--200793784(+) ACTCAT/CGTTGC 2 -- ut31 nc-transcript-variant21Minor allele frequency- C:0.10NA NS EA WA 2274
    rs1489523871,2
    C--200793889(+) TGGAA-/CTCTTAG 2 -- ut31 nc-transcript-variant0--------
    rs113113821,2
    C,F--200793928(+) GGGGGA/-AGGGA 2 -- ut31 nc-transcript-variant3Minor allele frequency- -:0.50NA 6
    rs614092961,2
    C--200794069(+) AAAAT-/AAATAG 2 -- ut31 nc-transcript-variant0--------
    rs1998078161,2
    C--200794138(+) AAGAC-/TTAAGG 2 -- ut31 nc-transcript-variant0--------
    rs1436558801,2
    C--200794164(+) TGGGT-/AGACTG 2 -- ut31 nc-transcript-variant0--------
    rs1388991091,2
    C--200794196(+) GACTA-/CATCATCT 2 -- cds1 nc-transcript-variant0--------
    rs361202181,2
    C--200794197(+) ACTAC-/A/A   
      TC
    /CAT
    ATCTA
    6 -- cds1 ut31 nc-transcript-variant0--------
    rs339433051,2
    C--200794278(+) CTGCA-/T/TT  
            
    TTTTT
    4 -- ut31 nc-transcript-variant1NA 2
    rs2014680741,2
    C--200794297(-) GTTGAA/CAAAAA 2 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for TYW5 (200793634 - 200820459 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TYW5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834510CNV Loss17160897
    nsv875704CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TYW5
    DNA2.0 Custom Variant and Variant Library Synthesis for TYW5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TYW5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TYW5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expanding role of the jumonji C domain as an RNA hydroxylase. (PubMed id 20739293)1, 2, 3 Noma A.... Suzuki T. (J. Biol. Chem. 2010)
    2. Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. (PubMed id 20972222)1, 2 Kato M....Nureki O. (Nucleic Acids Res. 2011)
    3. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 129450 HGNC: 26754 AceView: FLJ37953 Ensembl:ENSG00000162971 euGenes: HUgn129450
    ECgene: TYW5 H-InvDB: TYW5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TYW5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TYW5 gene:
    Search GeneIP for patents involving TYW5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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