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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TYW5 Gene

protein-coding GIFtS: 39
GCID: GC02M200794

tRNA-yW synthesizing protein 5

(Previous name: chromosome 2 open reading frame 60 )
(Previous symbol: C2orf60)

Explore 2 diseases affiliated with
TYW5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TRNA-YW Synthesizing Protein 5¹ ²		JmjC Domain-Containing Protein C2orf60²
C2orf60¹ ² ³		TRNA Wybutosine-Synthesizing Protein 5²
HTYW5¹		TRNA YW-Synthesizing Enzyme 5²
FLJ37953¹		EC 1.14.11.-³
Chromosome 2 Open Reading Frame 60¹

External Ids:	HGNC: 26754¹	Entrez Gene: 129450²	Ensembl: ENSG00000162971⁷	UniProtKB: A2RUC4³

ORGUL members:
	NONCODE:n406344

Export aliases for TYW5 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TYW5_HUMAN, A2RUC4

Function: tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper

modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic

phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified

hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a

derivative of wybutosine found in higher eukaryotes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for TYW5
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TYW5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TYW5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33.1

TYW5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TYW5 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M200794: view genomic region (about GC identifiers)

Start:	200,793,634 bp from pter	End:	200,820,459 bp from pter
Size:	26,826 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TYW5_HUMAN, A2RUC4 (See protein sequence)

Recommended Name: tRNA wybutosine-synthesizing protein 5

Size: 315 amino acids; 36548 Da

Cofactor: Binds 1 Fe(2+) ion per subunit

Subunit: Homodimer

Sequence caution: Sequence=AAH63502.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

2 PDB 3D structures from and Proteopedia for TYW5:

3AL5 (3D)

3AL6 (3D)

Secondary accessions: B2RNE3 Q8N1R2

Alternative splicing: 2 isoforms: A2RUC4-1 A2RUC4-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TYW5: NX_A2RUC4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A2RUC4

TYW5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001034782.1

ENSEMBL proteins:

ENSP00000346627 ENSP00000420024 ENSP00000398447

Human Recombinant Protein Products for TYW5:

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	Uscn Proteins for TYW5

TYW5 Antibody Products:

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Assay Products for TYW5:

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	GenScript Custom Assay Services for TYW5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TYW5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TYW5 for domains About GeneDecksing

1 InterPro domain/family:

IPR003347 JmjC_dom

Graphical View of Domain Structure for InterPro Entry A2RUC4

ProtoNet protein and cluster: A2RUC4

UniProtKB/Swiss-Prot: TYW5_HUMAN, A2RUC4

Similarity: Belongs to the TYW5 family

Similarity: Contains 1 JmjC domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TYW5_HUMAN, A2RUC4

Function: tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper

modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic

phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified

hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a

derivative of wybutosine found in higher eukaryotes

Enzyme Number (IUBMB): EC 1.14.11.-¹

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000049	tRNA binding	IDA	--
GO:0005506	iron ion binding	IDA	--
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	IDA	--
GO:0042803	protein homodimerization activity	IDA	--

TYW5 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TYW5

miRNA Products:		OriGene 3'-UTR Clone: TYW5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TYW5
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TYW5 (see all 16):
		hsa-miR-21* hsa-miR-579 hsa-miR-3194-5p hsa-miR-134 hsa-miR-29c hsa-miR-29a hsa-miR-4314 hsa-miR-511

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TYW5 OriGene shRNA RFP: TYW5 OriGene siRNA: TYW5
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		Sirion Biotech Custom design and validation of potent shRNA sequences against TYW5

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TYW5
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TYW5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TYW5 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYW5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

UniProtKB/Swiss-Prot: TYW5_HUMAN, A2RUC4

Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TYW5

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0031591	wybutosine biosynthetic process	IDA	--

TYW5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TYW5
Search CenterWatch for drugs/clinical trials and news about TYW5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TYW5 gene (2 alternative transcripts):

NM_152382.1 NM_001039693.2

Unigene Cluster for TYW5:

TRNA-yW synthesizing protein 5

Hs.204619 [show with all ESTs]

Unigene Representative Sequence: NM_001039693

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000354611(uc002uvi.4) ENST00000483328(uc002uvj.4 uc002uvk.4 uc010fss.3)

ENST00000452512 ENST00000441832 ENST00000493181(uc002uvl.3)

miRNA Products:		OriGene 3'-UTR Clone: TYW5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TYW5
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TYW5 (see all 16):
		hsa-miR-21* hsa-miR-579 hsa-miR-3194-5p hsa-miR-134 hsa-miR-29c hsa-miR-29a hsa-miR-4314 hsa-miR-511

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TYW5 OriGene shRNA RFP: TYW5 OriGene siRNA: TYW5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TYW5
		Sirion Biotech Custom design and validation of potent shRNA sequences against TYW5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TYW5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TYW5 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for TYW5
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TYW5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TYW5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TYW5

Additional cDNA sequence:

AK095272.1 AK293064.1 AK298977.1 BC025758.1 BC063502.1 BC132835.1 BC136837.1 BC144420.1

BX647677.1 NR_004862.1

8 DOTS entries:

DT.308338 DT.120941107 DT.211263 DT.211265 DT.454709 DT.100710886 DT.100714615 DT.111614

24/85 AceView cDNA sequences (see all 85):

BX094248 AI057373 AA632314 AI052737 BX107886 CB529067 BM721903 CB305779

BC063502 AI868437 AA700050 BF438043 T40732 BI769592 AA402102 BQ424547

AI685332 AK095272 AI274119 BE349015 W21118 BM465624 NM_152382 BM728466

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TYW5 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b
SP1:									-		-								-
SP2:									-		-								-		-
SP3:											-								-
SP4:									-		-
SP5:

ECgene alternative splicing isoforms for TYW5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TYW5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGAAACCTT

About this image
See TYW5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TYW5

SOURCE GeneReport for Unigene cluster: Hs.204619
SABiosciences Custom PCR Arrays for TYW5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TYW5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TYW5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYW5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TYW5 gene from 4/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TYW5¹	tRNA-yW synthesizing protein 5	77.2(n) 77.52(a)		424065 XM_421921.2 XP_421921.2
lizard (Anolis carolinensis)	Reptilia	TYW5⁶	--	78(a)	1 ↔ 1	1(117571541-117587858)
African clawed frog (Xenopus laevis)	Amphibia	BJ077044.1²	--	76.74(n)		BJ077044.1
zebrafish (Danio rerio)	Actinopterygii	Dr.14896²	Transcribed sequence with weak similarity to protein more	72.96(n)		BM035027.1

ENSEMBL Gene Tree for TYW5 (if available)
TreeFam Gene Tree for TYW5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TYW5 gene

JMJD7² HSPBAP1² KDM8² HIF1AN²

TYW5 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TYW5
PGOHUM00000238264

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10202253^1,2	C,F,H	--	200793205(+)	`ACAACA/GAACAA`	3	--	int¹		20		NS EA NA WA	2338
rs74511880^1,2		--	200793226(+)	`ACCTGC/GTGTTT`	3	--	int¹		0	--	--	--	--
rs77160058^1,2	F	--	200793324(+)	`TTTCAA/GATGAG`	3	--	int¹		1		NA	120
rs140210719^1,2	C	--	200793341(+)	`TGAAC-/CTTTTTTG`	3	--	int¹		0	--	--	--	--
rs151293001^1,2		--	200793349(+)	`TTTTGC/TACAAA`	3	--	int¹		0	--	--	--	--
rs189347859^1,2		--	200793400(+)	`CACTAC/TATCCA`	3	--	int¹		0	--	--	--	--
rs146625788^1,2		--	200793406(+)	`ATCCA-/CTTCTTTT`	3	--	int¹		0	--	--	--	--
rs16832051^1,2	C,F,H	--	200793784(+)	`ACTCAT/CGTTGC`	2	--	nc-transcript-variantut3¹		21		NA NS EA WA	2274
rs148952387^1,2	C	--	200793889(+)	`TGGAA-/CTCTTAG`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs11311382^1,2	C,F	--	200793928(+)	`GGGGGA/-AGGGA`	2	--	ut3¹ nc-transcript-variant		3		NA	6

HapMap Linkage Disequilibrium report for TYW5 (200793634 - 200820459 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TYW5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TYW5

DNA2.0 Custom Variant and Variant Library Synthesis for TYW5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TYW5 for disorders About GeneDecksing

2 diseases for TYW5: About MalaCards

noma malaria

Export disorders for TYW5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TYW5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TYW5)

Utopia: connect your pdf to the dynamic
world of online information

Expanding role of the jumonji C domain as an RNA hydroxylase. (PubMed id 20739293)^{1, 2, 3} Noma A.... Suzuki T. (2010)
Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. (PubMed id 20972222)^{1, 2} Kato M....Nureki O. (2011)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 129450	HGNC: 26754	AceView: FLJ37953	Ensembl:ENSG00000162971	euGenes: HUgn129450
ECgene: TYW5	H-InvDB: TYW5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TYW5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TYW5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TYW5 gene:
Search GeneIP for patents involving TYW5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	EMD Millipore Custom Antibody & Bulk Services
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	Browse OriGene Antibodies		OriGene shRNA RFP for TYW5
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TYW5		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TYW5
	OriGene Protein Over-expression Lysate for TYW5		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TYW5		OriGene 3'-UTR Clone for TYW5
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TYW5		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TYW5
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TYW5		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TYW5		OriGene Custom Protein Services for TYW5
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TYW5
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TYW5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TYW5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TYW5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TYW5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TYW5

	GenScript Custom Purified and Recombinant Proteins Services for TYW5		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TYW5
	GenScript Custom Assay Services for TYW5		GenScript Custom Superior Antibodies Services for TYW5
	GenScript Custom overexpressing Cell Line Services for TYW5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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TYW5 Proteins, Antibodies, CLIAs, and ELISAs

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	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYW5

	Browse SwitchGear 3'UTR luciferase reporter plasmids for TYW5
	Browse SwitchGear Promoter luciferase reporter plasmids for TYW5

ThermoFisher Antibody for TYW5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYW5

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TYW5

Sirion Biotech Customized:

	stable knockdown cell line services for TYW5
	inducible knockdown cell line services for TYW5
	design and validation of potent shRNA sequences against TYW5
	adenovirus for potent knockdown of TYW5
	adenovirus for overexpression of TYW5
	stable overexpressing cell line services for TYW5
	inducible overexpressing cell line services for TYW5

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TYW5 gene at Home site.

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TYW5 Gene

tRNA-yW synthesizing protein 5

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TYW5 Gene

tRNA-yW synthesizing protein 5

Aliasesfor TYW5 gene

Summariesfor TYW5 gene

Genomic Viewsfor TYW5 gene

Proteinsfor TYW5 gene

Protein Domains /Familiesfor TYW5 gene

Functionfor TYW5 gene

Pathways & Interactionsfor TYW5 gene

Drugs & Compoundsfor TYW5 gene

Transcriptsfor TYW5 gene

Expression for TYW5 gene

Orthologsfor TYW5 gene

Paralogsfor TYW5 gene

Genomic Variantsfor TYW5 gene

Disorders / Diseasesfor TYW5 gene

Publicationsfor TYW5 gene

External Searches for TYW5 gene

Genome Databases showing TYW5 gene

Other Databases showing TYW5 gene

Specialized Databases showing TYW5 gene

Intellectual Propertyfor TYW5 gene

Productsfor TYW5 gene

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Aliases
for TYW5 gene

Summaries
for TYW5 gene

Genomic Views
for TYW5 gene

Proteins
for TYW5 gene

Protein Domains /
Families
for TYW5 gene

Function
for TYW5 gene

Pathways & Interactions
for TYW5 gene

Drugs & Compounds
for TYW5 gene

Transcripts
for TYW5 gene

Expression
for TYW5 gene

Orthologs
for TYW5 gene

Paralogs
for TYW5 gene

Genomic Variants
for TYW5 gene

Disorders / Diseases
for TYW5 gene

Publications
for TYW5 gene

Intellectual Property
for TYW5 gene

Products
for TYW5 gene