Aliases for TYW5 Gene
External Ids for TYW5 Gene
Previous HGNC Symbols for TYW5 Gene
Previous GeneCards Identifiers for TYW5 Gene
GeneCards Summary for TYW5 Gene
TYW5 (TRNA-YW Synthesizing Protein 5) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and tRNA binding. An important paralog of this gene is HSPBAP1.
UniProtKB/Swiss-Prot for TYW5 Gene
tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.