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TYW3 Gene

protein-coding   GIFtS: 53
GCID: GC01P075198

TRNA-YW Synthesizing Protein 3 Homolog (S. Cerevisiae)

(Previous name: chromosome 1 open reading frame 171)
(Previous symbol: C1orf171)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
TRNA-YW Synthesizing Protein 3 Homolog (S. Cerevisiae)1 2     TRNA Wybutosine-Synthesizing Protein 3 Homolog2
C1orf1711 2 3     EC 2.1.1.2823
TRNA-YW-Synthesizing Protein 32 3     EC 2.1.18
Chromosome 1 Open Reading Frame 1711     

External Ids:    HGNC: 247571   Entrez Gene: 1272532   Ensembl: ENSG000001626237   OMIM: 6112455   UniProtKB: Q6IPR33   
ORGUL members:         

Export aliases for TYW3 gene to outside databases

Previous GC identifers: GC01P074971 GC01P073333


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TYW3 Gene:
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine
tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a
yeast gene essential for yW synthesis (Noma and Suzuki, 2006).(supplied by OMIM, Mar 2008)

GeneCards Summary for TYW3 Gene:
TYW3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with TYW3 include noma. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot: TYW3_HUMAN, Q6IPR3
Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine
biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position
adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TYW3 gene promoter:
         COUP-TF1   COUP   HNF-4alpha1   NF-AT   Gfi-1   NF-AT4   NF-AT2   COUP-TF   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTYW3 promoter sequence
   Search Chromatin IP Primers for TYW3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TYW3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

TYW3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TYW3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P075198:  view genomic region     (about GC identifiers)

Start:
75,198,836 bp from pter      End:
75,232,362 bp from pter
Size:
33,527 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TYW3

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TYW3_HUMAN, Q6IPR3 (See protein sequence)
Recommended Name: tRNA wybutosine-synthesizing protein 3 homolog  
Size: 259 amino acids; 29794 Da
Sequence caution: Sequence=CAI46106.1; Type=Erroneous initiation;
Secondary accessions: B4DSP9 E9PGR7 Q5HYJ0 Q8N7L1
Alternative splicing: 2 isoforms:  Q6IPR3-1   Q6IPR3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TYW3: NX_Q6IPR3

Explore proteomics data for TYW3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TYW3 (Q6IPR3) (see all 6)
     KGSVDED  GKLMVTEEYI  CVKDDVIVAL  GFRNSGITVGK 


    See TYW3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001156388.1  NP_612476.1  

    ENSEMBL proteins: 
     ENSP00000359904   ENSP00000477469   ENSP00000476365   ENSP00000407025   ENSP00000409336  

    TYW3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TYW3
    OriGene Protein Over-expression Lysate for TYW3
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    GenScript Custom Purified and Recombinant Proteins Services for TYW3
    Novus Biologicals TYW3 Proteins
    Novus Biologicals TYW3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TYW3

    TYW3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    Novus Biologicals TYW3 Antibodies
    Abcam antibodies for TYW3
    Cloud-Clone Corp. Antibodies for TYW3
    ThermoFisher Antibodies for TYW3
    LSBio Antibodies in human, mouse, rat for TYW3

    TYW3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TYW3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TYW3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TYW3
    Cloud-Clone Corp. CLIAs for TYW3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003827 tRNA_yW-synthesising

    Graphical View of Domain Structure for InterPro Entry Q6IPR3

    ProtoNet protein and cluster: Q6IPR3

    1 Blocks protein domain: IPB003827 Protein of unknown function DUF207

    UniProtKB/Swiss-Prot: TYW3_HUMAN, Q6IPR3
    Similarity: Belongs to the TYW3 family


    TYW3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYW3_HUMAN, Q6IPR3
    Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine
    biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position
    adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity)
    Catalytic activity: S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl)-4-demethyl)wyosine(37) in
    tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-(3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe)

         Enzyme Numbers (IUBMB): EC 2.1.12 EC 2.1.1.2821

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity IEA--
         
    TYW3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TYW3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TYW3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TYW3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TYW3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TYW3:
    hsa-mir-328-3p (MIRT043795), hsa-mir-24-3p (MIRT030497), hsa-mir-193b-3p (MIRT016492)

    Block miRNA regulation of human, mouse, rat TYW3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TYW3 (see all 12):
    hsa-miR-3685 hsa-miR-361-5p hsa-miR-125a-3p hsa-miR-3065-5p hsa-miR-2278 hsa-miR-1285 hsa-miR-374a* hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidTYW3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TYW3
    Predesigned siRNA for gene silencing in human, mouse, rat TYW3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TYW3

    Clone
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    OriGene clones in human, mouse for TYW3 (see all 14)
    OriGene ORF clones in mouse, rat for TYW3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TYW3 (NM_138467)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TYW3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYW3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TYW3
    Browse ESI BIO Cell Lines and PureStem Progenitors for TYW3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYW3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    nucleus2
    cytosol1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TYW3 About    
    See pathways by source

    SuperPathContained pathways About
    1wybutosine biosynthesis
    7-(3-amino-3-carboxypropyl)-wyosine biosynthesis0.00
    wybutosine biosynthesis


    2 BioSystems Pathways for TYW3
        wybutosine biosynthesis
    7-(3-amino-3-carboxypropyl)-wyosine biosynthesis


    UniProtKB/Swiss-Prot: TYW3_HUMAN, Q6IPR3
    Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TYW3
    Interactions:

        Search GeneGlobe Interaction Network for TYW3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for TYW3 (ENSP000003599044) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    N6AMT1ENSP000003035844STRING: ENSP00000303584
    HEMK1ENSP000002328544STRING: ENSP00000232854
    GBF1ENSP000003590004STRING: ENSP00000359000
    CNPPD1ENSP000003536984STRING: ENSP00000353698
    ZC3H14ENSP000002510384STRING: ENSP00000251038
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008033tRNA processing IEA--

    TYW3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TYW3

    1 HMDB Compound for TYW3    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TYW3 gene (2 alternative transcripts): 
    NM_001162916.1  NM_138467.2  

    Unigene Cluster for TYW3:

    TRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
    Hs.348411  [show with all ESTs]
    Unigene Representative Sequence: NR_027962
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370867(uc001dgn.3 uc010oqy.2) ENST00000479111 ENST00000483990
    ENST00000485401 ENST00000449696 ENST00000486467 ENST00000467646 ENST00000457880(uc010oqw.2 uc010oqx.2)
    ENST00000421739
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TYW3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TYW3 (see all 12):
    hsa-miR-3685 hsa-miR-361-5p hsa-miR-125a-3p hsa-miR-3065-5p hsa-miR-2278 hsa-miR-1285 hsa-miR-374a* hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidTYW3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TYW3
    Predesigned siRNA for gene silencing in human, mouse, rat TYW3
    Clone
    Products:
         
    OriGene clones in human, mouse for TYW3 (see all 14)
    OriGene ORF clones in mouse, rat for TYW3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TYW3 (NM_138467)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TYW3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYW3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TYW3
    OriGene qSTAR qPCR primer pairs in human, mouse for TYW3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TYW3
      QuantiTect SYBR Green Assays in human, mouse, rat TYW3
      QuantiFast Probe-based Assays in human, mouse, rat TYW3

    Additional mRNA sequence: 

    AK098237.1 AK294264.1 AK299849.1 AK311272.1 BC009514.1 BC009532.1 BC015841.1 BC020995.1 
    BC032341.2 BC071765.1 BX647591.1 NR_027962.1 

    12 DOTS entries:

    DT.451787  DT.100026465  DT.100026464  DT.121406044  DT.91911898  DT.95260818  DT.97842442  DT.100788988 
    DT.75122207  DT.97842444  DT.100788990  DT.317064 

    Selected AceView cDNA sequences (see all 152):

    CA950104 AA336826 BC071765 BQ901030 AI335843 AI288591 BM800457 AA515795 
    CA429096 BC032341 CA426444 BI438392 BQ082083 AK098237 AI623431 BU618598 
    BM353058 AA316207 BM129774 AA258937 BM314660 AA760736 BM463015 BI756201 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TYW3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
    SP1:                          -           -           -                 -               
    SP2:                          -           -           -                                 
    SP3:                          -                       -                                 
    SP4:                                      -           -                                 
    SP5:                                                                    -               


    ECgene alternative splicing isoforms for TYW3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TYW3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGGAAAG
    TYW3 Expression
    About this image

    TYW3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TYW3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.348411
        Custom PCR Arrays for TYW3
    Primer
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    OriGene qPCR primer pairs and template standards for TYW3
    OriGene qSTAR qPCR primer pairs in human, mouse for TYW3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TYW3
    QuantiTect SYBR Green Assays in human, mouse, rat TYW3
    QuantiFast Probe-based Assays in human, mouse, rat TYW3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYW3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TYW3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tyw31 , 5 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) less1, 5 78.92(n)1
    73.93(a)1
      3 (79.24 cM)5
    2095841  NM_172474.51  NP_766062.11 
     1545771995 
    chicken
    (Gallus gallus)
    Aves TYW31 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) less 63.84(n)
    54.91(a)
      424720  NM_001277635.1  NP_001264564.1 
    lizard
    (Anolis carolinensis)
    Reptilia TYW36
    tRNA-yW synthesizing protein 3 homolog (S. cerevis...
    53(a)
    1 ↔ 1
    GL343194.1(2802069-2822769)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX848301.12   -- 78.04(n)    BX848301.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tyw31 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) less 61.73(n)
    59.72(a)
      436884  NM_001002611.1  NP_001002611.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TYW3(YGL050W)4
    TYW31
    tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions less4
    TYW31
    45.41(n)1
    34.3(a)1
      7(405776-406597)4
    8528321, 4  NP_011465.31  NP_011465.14 


    ENSEMBL Gene Tree for TYW3 (if available)
    TreeFam Gene Tree for TYW3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TYW3 (see all 680)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1917663291,2
    --75201227(+) ACTTAC/TAAACA 3 -- int10--------
    rs1813678961,2
    --75201378(+) AGATTC/GAGAGT 3 -- int10--------
    rs1130824381,2
    C,F--75201421(+) TCACCG/AAAGTC 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1417944331,2
    --75201809(+) GTGACA/GATAAA 3 -- int10--------
    rs763957261,2
    F--75201861(+) CAAAAG/AAAATT 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1863950031,2
    C--75201886(+) TTCATG/TTTTAA 3 -- int10--------
    rs729700391,2
    C,F--75202017(+) TTTACA/C/GTTTCA 3 -- int13WA 122
    rs1460694411,2
    C--75202149(+) AGCCTA/GCAATA 3 -- int10--------
    rs1389274111,2
    --75202150(+) GCCTAA/CAATAT 3 -- int10--------
    rs1122608871,2
    F--75202165(+) TGCATC/TATGCT 3 -- int11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for TYW3 (75198836 - 75232362 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TYW3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509346CNV Insertion20534489
    nsv830259CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611245    OMIM disorders: --

    1 disease for TYW3:    
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    noma


    TYW3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TYW3

    Export disorders for TYW3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TYW3 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with TYW3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. (PubMed id 17150819)1, 3 Noma A. and Suzuki T. (Nucleic Acids Symp Ser (Oxf) 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PubMed id 22843503)1 Qi Q....Qi L. (Hum. Mol. Genet. 2012)
    5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    6. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)
    7. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 127253 HGNC: 24757 AceView: LOC127253 Ensembl:ENSG00000162623 euGenes: HUgn127253
    ECgene: TYW3 H-InvDB: TYW3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TYW3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TYW3 gene:
    Search GeneIP for patents involving TYW3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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