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Aliases for TYW3 Gene

Aliases for TYW3 Gene

  • TRNA-YW Synthesizing Protein 3 Homolog (S. Cerevisiae) 2 3
  • TRNA(Phe) 7-((3-Amino-3-Carboxypropyl)-4-Demethylwyosine(37)-N(4))-Methyltransferase 3 4
  • TRNA-YW-Synthesizing Protein 3 3 4
  • C1orf171 3 4
  • TRNA Wybutosine-Synthesizing Protein 3 Homolog 3
  • Chromosome 1 Open Reading Frame 171 2
  • EC 4
  • EC 2.1.1 63

External Ids for TYW3 Gene

Previous HGNC Symbols for TYW3 Gene

  • C1orf171

Previous GeneCards Identifiers for TYW3 Gene

  • GC01P074971
  • GC01P075198
  • GC01P073333

Summaries for TYW3 Gene

Entrez Gene Summary for TYW3 Gene

  • Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]

GeneCards Summary for TYW3 Gene

TYW3 (TRNA-YW Synthesizing Protein 3 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with TYW3 include noma. Among its related pathways are wybutosine biosynthesis and wybutosine biosynthesis. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for TYW3 Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYW3 Gene

Genomics for TYW3 Gene

Regulatory Elements for TYW3 Gene

Genomic Location for TYW3 Gene

74,733,143 bp from pter
74,766,678 bp from pter
33,536 bases
Plus strand

Genomic View for TYW3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TYW3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYW3 Gene

Proteins for TYW3 Gene

  • Protein details for TYW3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA wybutosine-synthesizing protein 3 homolog
    Protein Accession:
    Secondary Accessions:
    • B4DSP9
    • E9PGR7
    • Q5HYJ0
    • Q8N7L1

    Protein attributes for TYW3 Gene

    259 amino acids
    Molecular mass:
    29794 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI46106.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TYW3 Gene


neXtProt entry for TYW3 Gene

Proteomics data for TYW3 Gene at MOPED

Selected DME Specific Peptides for TYW3 Gene

Post-translational modifications for TYW3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TYW3 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TYW3

Domains for TYW3 Gene

Protein Domains for TYW3 Gene

Suggested Antigen Peptide Sequences for TYW3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6IPR3
  • Belongs to the TYW3 family.
genes like me logo Genes that share domains with TYW3: view

No data available for Gene Families for TYW3 Gene

Function for TYW3 Gene

Molecular function for TYW3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4-demethylwyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-(3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe)
UniProtKB/Swiss-Prot Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).

Enzyme Numbers (IUBMB) for TYW3 Gene

Gene Ontology (GO) - Molecular Function for TYW3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with TYW3: view

Animal Model Products

miRNA for TYW3 Gene

miRTarBase miRNAs that target TYW3

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TYW3 Gene

Localization for TYW3 Gene

Subcellular locations from

Jensen Localization Image for TYW3 Gene COMPARTMENTS Subcellular localization image for TYW3 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TYW3 Gene

Pathways for TYW3 Gene

genes like me logo Genes that share pathways with TYW3: view

Pathways by source for TYW3 Gene

UniProtKB/Swiss-Prot Q6IPR3-TYW3_HUMAN

  • Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis

Interacting Proteins for TYW3 Gene

Gene Ontology (GO) - Biological Process for TYW3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TYW3: view

Compounds for TYW3 Gene

(1) HMDB Compounds for TYW3 Gene

Compound Synonyms Cas Number PubMed IDs
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
genes like me logo Genes that share compounds with TYW3: view

Transcripts for TYW3 Gene

Unigene Clusters for TYW3 Gene

TRNA-yW synthesizing protein 3 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TYW3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TYW3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for TYW3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TYW3 Gene

mRNA expression in normal human tissues for TYW3 Gene

Protein differential expression in normal tissues for TYW3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.1), Testis (11.0), and Retina (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TYW3 Gene

SOURCE GeneReport for Unigene cluster for TYW3 Gene Hs.348411

genes like me logo Genes that share expressions with TYW3: view

Expression partners for TYW3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TYW3 Gene

Orthologs for TYW3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TYW3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TYW3 35
  • 85.53 (n)
  • 80.62 (a)
TYW3 36
  • 81 (a)
(Canis familiaris)
Mammalia TYW3 35
  • 89.5 (n)
  • 86.5 (a)
TYW3 36
  • 84 (a)
(Mus musculus)
Mammalia Tyw3 35
  • 78.92 (n)
  • 73.93 (a)
Tyw3 16
Tyw3 36
  • 70 (a)
(Pan troglodytes)
Mammalia TYW3 35
  • 99.23 (n)
  • 99.23 (a)
TYW3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tyw3 35
  • 79.28 (n)
  • 77.48 (a)
(Monodelphis domestica)
Mammalia TYW3 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia TYW3 36
  • 63 (a)
(Gallus gallus)
Aves TYW3 35
  • 63.84 (n)
  • 54.91 (a)
TYW3 36
  • 47 (a)
(Anolis carolinensis)
Reptilia TYW3 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15234 35
tyw3 35
  • 62.48 (n)
  • 54.11 (a)
(Danio rerio)
Actinopterygii tyw3 35
  • 61.73 (n)
  • 59.72 (a)
tyw3 36
  • 54 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL045W 35
  • 42.97 (n)
  • 30.39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TYW3 35
  • 45.41 (n)
  • 34.3 (a)
TYW3 36
  • 25 (a)
TYW3 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC25B8.15c 35
  • 44.5 (n)
  • 36.08 (a)
Species with no ortholog for TYW3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TYW3 Gene

Gene Tree for TYW3 (if available)
Gene Tree for TYW3 (if available)

Paralogs for TYW3 Gene

No data available for Paralogs for TYW3 Gene

Variants for TYW3 Gene

Sequence variations from dbSNP and Humsavar for TYW3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9647 -- 74,766,547(-) ctgta(A/C)aaaat utr-variant-3-prime, nc-transcript-variant
rs10161 -- 74,766,529(-) tatat(C/T)cttat utr-variant-3-prime, nc-transcript-variant
rs16910 -- 74,737,028(+) TTTTT(G/T)AAAAT intron-variant
rs277368 -- 74,764,922(-) GACTC(A/G)CATCA utr-variant-3-prime, nc-transcript-variant, intron-variant
rs277375 -- 74,738,459(-) TCCAC(C/T)TATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TYW3 Gene

Variant ID Type Subtype PubMed ID
nsv830259 CNV Gain 17160897
nsv509346 CNV Insertion 20534489

Relevant External Links for TYW3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYW3 Gene

Disorders for TYW3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TYW3 Gene in MalaCards »

(1) Diseases for TYW3 Gene including...

Relevant External Links for TYW3

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TYW3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TYW3 Gene

Publications for TYW3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. (PMID: 17150819) Noma A. … Suzuki T. (Nucleic Acids Symp Ser (Oxf) 2006) 2 3
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  5. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PMID: 22843503) Qi Q. … Qi L. (Hum. Mol. Genet. 2012) 3

Products for TYW3 Gene

Sources for TYW3 Gene

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