Aliases for TYW3 Gene
- TRNA-YW Synthesizing Protein 3 Homolog (S. Cerevisiae) 2 3
- TRNA(Phe) 7-((3-Amino-3-Carboxypropyl)-4-Demethylwyosine(37)-N(4))-Methyltransferase 3 4
- TRNA-YW-Synthesizing Protein 3 3 4
- C1orf171 3 4
- TRNA Wybutosine-Synthesizing Protein 3 Homolog 3
- Chromosome 1 Open Reading Frame 171 2
- EC 220.127.116.112 4
- EC 2.1.1 64
External Ids for TYW3 Gene
Previous Symbols for TYW3 Gene
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]
GeneCards Summary for TYW3 Gene
TYW3 (TRNA-YW Synthesizing Protein 3 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with TYW3 include noma. Among its related pathways are wybutosine biosynthesis and wybutosine biosynthesis. GO annotations related to this gene include methyltransferase activity.
UniProtKB/Swiss-Prot for TYW3 Gene
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).