Aliases for TYW3 Gene
External Ids for TYW3 Gene
Previous HGNC Symbols for TYW3 Gene
Previous GeneCards Identifiers for TYW3 Gene
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]
GeneCards Summary for TYW3 Gene
TYW3 (TRNA-YW Synthesizing Protein 3 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with TYW3 include noma. Among its related pathways are Gene Expression and tRNA modification in the nucleus and cytosol. GO annotations related to this gene include methyltransferase activity.
UniProtKB/Swiss-Prot for TYW3 Gene
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).