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Aliases for TYW3 Gene

Aliases for TYW3 Gene

  • TRNA-YW Synthesizing Protein 3 Homolog 2 3 5
  • TRNA(Phe) 7-((3-Amino-3-Carboxypropyl)-4-Demethylwyosine(37)-N(4))-Methyltransferase 3 4
  • TRNA-YW-Synthesizing Protein 3 3 4
  • C1orf171 3 4
  • TRNA-YW Synthesizing Protein 3 Homolog (S. Cerevisiae) 2
  • TRNA Wybutosine-Synthesizing Protein 3 Homolog 3
  • Chromosome 1 Open Reading Frame 171 2
  • EC 4
  • EC 2.1.1 56

External Ids for TYW3 Gene

Previous HGNC Symbols for TYW3 Gene

  • C1orf171

Previous GeneCards Identifiers for TYW3 Gene

  • GC01P074971
  • GC01P075198
  • GC01P073333

Summaries for TYW3 Gene

Entrez Gene Summary for TYW3 Gene

  • Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]

GeneCards Summary for TYW3 Gene

TYW3 (TRNA-YW Synthesizing Protein 3 Homolog) is a Protein Coding gene. Diseases associated with TYW3 include Noma. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for TYW3 Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).

Additional gene information for TYW3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYW3 Gene

Genomics for TYW3 Gene

GeneHancer (GH) Regulatory Elements for TYW3 Gene

Promoters and enhancers for TYW3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I074729 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 568 -0.7 -736 5.1 PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 CRYZ TYW3 ENSG00000272864
GH01I074964 Enhancer 0.9 UCNEbase 12.7 +231.4 231372 0.3 ZBTB6 L3MBTL2 ZBTB21 NFIB ZNF529 ZNF398 ZNF491 OSR2 PRDM6 NFIC ENSG00000229943 TYW3 DLSTP1 GC01P074970
GH01I074693 Enhancer 0.2 ENCODE 4.9 -39.3 -39333 1 ERICH3 LRRC53 ENSG00000272864 TYW3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TYW3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TYW3 gene promoter:

Genomic Locations for TYW3 Gene

Genomic Locations for TYW3 Gene
33,536 bases
Plus strand

Genomic View for TYW3 Gene

Genes around TYW3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYW3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYW3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYW3 Gene

Proteins for TYW3 Gene

  • Protein details for TYW3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA wybutosine-synthesizing protein 3 homolog
    Protein Accession:
    Secondary Accessions:
    • B4DSP9
    • E9PGR7
    • Q5HYJ0
    • Q8N7L1

    Protein attributes for TYW3 Gene

    259 amino acids
    Molecular mass:
    29794 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI46106.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TYW3 Gene


neXtProt entry for TYW3 Gene

Selected DME Specific Peptides for TYW3 Gene


Post-translational modifications for TYW3 Gene

No Post-translational modifications

Other Protein References for TYW3 Gene

Domains & Families for TYW3 Gene

Gene Families for TYW3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TYW3 Gene

Suggested Antigen Peptide Sequences for TYW3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TYW3 family.
  • Belongs to the TYW3 family.
genes like me logo Genes that share domains with TYW3: view

Function for TYW3 Gene

Molecular function for TYW3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4-demethylwyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-(3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe).
UniProtKB/Swiss-Prot Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).

Enzyme Numbers (IUBMB) for TYW3 Gene

Phenotypes From GWAS Catalog for TYW3 Gene

Gene Ontology (GO) - Molecular Function for TYW3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TYW3: view

Phenotypes for TYW3 Gene

GenomeRNAi human phenotypes for TYW3:
genes like me logo Genes that share phenotypes with TYW3: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TYW3 Gene

Localization for TYW3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TYW3 gene
Compartment Confidence
plasma membrane 3
cytosol 3
extracellular 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TYW3 Gene

Pathways & Interactions for TYW3 Gene

genes like me logo Genes that share pathways with TYW3: view

UniProtKB/Swiss-Prot Q6IPR3-TYW3_HUMAN

  • Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis.

Interacting Proteins for TYW3 Gene

Gene Ontology (GO) - Biological Process for TYW3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TYW3: view

No data available for SIGNOR curated interactions for TYW3 Gene

Drugs & Compounds for TYW3 Gene

(1) Additional Compounds for TYW3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
genes like me logo Genes that share compounds with TYW3: view

Transcripts for TYW3 Gene

Unigene Clusters for TYW3 Gene

TRNA-yW synthesizing protein 3 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TYW3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for TYW3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TYW3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TYW3 Gene

Protein differential expression in normal tissues from HIPED for TYW3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.1), Testis (11.0), and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TYW3 Gene

Protein tissue co-expression partners for TYW3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TYW3 Gene:


SOURCE GeneReport for Unigene cluster for TYW3 Gene:


Evidence on tissue expression from TISSUES for TYW3 Gene

  • Nervous system(4.5)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with TYW3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TYW3 Gene

Orthologs for TYW3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TYW3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TYW3 33 34
  • 99.23 (n)
(Canis familiaris)
Mammalia TYW3 33 34
  • 89.5 (n)
(Bos Taurus)
Mammalia TYW3 33 34
  • 85.53 (n)
(Rattus norvegicus)
Mammalia Tyw3 33
  • 79.28 (n)
(Mus musculus)
Mammalia Tyw3 33 16 34
  • 78.92 (n)
(Monodelphis domestica)
Mammalia TYW3 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia TYW3 34
  • 63 (a)
(Gallus gallus)
Aves TYW3 33 34
  • 63.84 (n)
(Anolis carolinensis)
Reptilia TYW3 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tyw3 33
  • 62.48 (n)
Str.15234 33
(Danio rerio)
Actinopterygii tyw3 33 34
  • 61.73 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TYW3 33 34 36
  • 45.41 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL045W 33
  • 42.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC25B8.15c 33
  • 44.5 (n)
Species where no ortholog for TYW3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TYW3 Gene

Gene Tree for TYW3 (if available)
Gene Tree for TYW3 (if available)

Paralogs for TYW3 Gene

No data available for Paralogs for TYW3 Gene

Variants for TYW3 Gene

Sequence variations from dbSNP and Humsavar for TYW3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000022571 -- 74,732,099(+) G/T upstream_transcript_variant
rs1000052765 -- 74,742,023(+) T/C intron_variant
rs1000198582 -- 74,763,966(+) A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000223268 -- 74,735,655(+) A/G intron_variant
rs1000271426 -- 74,746,631(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TYW3 Gene

Variant ID Type Subtype PubMed ID
nsv1002115 CNV gain 25217958
nsv473292 CNV novel sequence insertion 20440878
nsv509346 CNV insertion 20534489
nsv546579 CNV loss 21841781
nsv830259 CNV gain 17160897

Variation tolerance for TYW3 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.20; 84.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TYW3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYW3 Gene

Disorders for TYW3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TYW3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • cancrum oris
- elite association - COSMIC cancer census association via MalaCards
Search TYW3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TYW3

genes like me logo Genes that share disorders with TYW3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TYW3 Gene

Publications for TYW3 Gene

  1. Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. (PMID: 17150819) Noma A … Suzuki T (Nucleic acids symposium series (2004) 2006) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for TYW3 Gene

Sources for TYW3 Gene

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