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Aliases for TYW1B Gene

Aliases for TYW1B Gene

  • TRNA-YW Synthesizing Protein 1 Homolog B (S. Cerevisiae) 2 3
  • Radical S-Adenosyl Methionine And Flavodoxin Domain-Containing Protein 2 3 4
  • TRNA-YW Synthesizing Protein 1 Homolog B (Non-Protein Coding) 2 3
  • Radical S-Adenosyl Methionine And Flavodoxin Domains 1 2 3
  • TRNA Wybutosine-Synthesizing Protein 1 Homolog B 3 4
  • Long Intergenic Non-Protein Coding RNA 69 2 3
  • RSAFD2 3 4
  • S-Adenosyl-L-Methionine-Dependent TRNA 4-Demethylwyosine Synthase 3
  • Non-Protein Coding RNA 69 2
  • EC 4.1.3.44 4
  • NCRNA00069 3
  • LINC00069 3

External Ids for TYW1B Gene

Previous GeneCards Identifiers for TYW1B Gene

  • GC07M071680
  • GC07M071683
  • GC07M071686
  • GC07M072023
  • GC07M068192

Summaries for TYW1B Gene

Entrez Gene Summary for TYW1B Gene

  • Wybutosine is a hypermodified guanosine found in phenylalanine tRNA. Wybutosine functions to stabilize codon-anticodon interactions during ribosome decoding and therefore supports the maintenance of the reading frame. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. The human genome contains two closely related genes that putatively function in wybutosine synthesis. The open reading frame of this locus is disrupted in some individuals. Thus, this locus appears to be an evolving pseudogene, but may still be functional in some members of the population. [provided by RefSeq, Apr 2014]

GeneCards Summary for TYW1B Gene

TYW1B (TRNA-YW Synthesizing Protein 1 Homolog B (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and 4 iron, 4 sulfur cluster binding.

UniProtKB/Swiss-Prot for TYW1B Gene

  • Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYW1B Gene

Genomics for TYW1B Gene

Regulatory Elements for TYW1B Gene

Genomic Location for TYW1B Gene

Start:
72,558,744 bp from pter
End:
72,828,234 bp from pter
Size:
269,491 bases
Orientation:
Minus strand

Genomic View for TYW1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TYW1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYW1B Gene

Proteins for TYW1B Gene

  • Protein details for TYW1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUM6-TYW1B_HUMAN
    Recommended name:
    S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
    Protein Accession:
    Q6NUM6
    Secondary Accessions:
    • A6NG09
    • B4DFY2
    • Q3KQX2

    Protein attributes for TYW1B Gene

    Size:
    668 amino acids
    Molecular mass:
    76916 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TYW1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TYW1B Gene

Proteomics data for TYW1B Gene at MOPED

Post-translational modifications for TYW1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TYW1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TYW1B Gene

Domains for TYW1B Gene

Suggested Antigen Peptide Sequences for TYW1B Gene

Graphical View of Domain Structure for InterPro Entry

Q6NUM6

UniProtKB/Swiss-Prot:

TYW1B_HUMAN :
  • Q6NUM6
Domain:
  • Contains 1 flavodoxin-like domain.
Family:
  • Belongs to the TYW1 family.
genes like me logo Genes that share domains with TYW1B: view

No data available for Gene Families for TYW1B Gene

Function for TYW1B Gene

Molecular function for TYW1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
N(1)-methylguanine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + L-methionine + 5-deoxyadenosine + CO(2) + H(2)O
UniProtKB/Swiss-Prot Function:
Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).

Enzyme Numbers (IUBMB) for TYW1B Gene

Gene Ontology (GO) - Molecular Function for TYW1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005506 iron ion binding IEA --
GO:0010181 FMN binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with TYW1B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TYW1B

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TYW1B Gene

Localization for TYW1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TYW1B Gene COMPARTMENTS Subcellular localization image for TYW1B gene
Compartment Confidence
cytosol 3
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TYW1B Gene

Pathways for TYW1B Gene

SuperPathways for TYW1B Gene

No Data Available

UniProtKB/Swiss-Prot Q6NUM6-TYW1B_HUMAN

  • Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis

Interacting Proteins for TYW1B Gene

Gene Ontology (GO) - Biological Process for TYW1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with TYW1B: view

No data available for Pathways by source for TYW1B Gene

Compounds for TYW1B Gene

(2) HMDB Compounds for TYW1B Gene

Compound Synonyms Cas Number PubMed IDs
Flavin Mononucleotide
  • FMN
146-17-8
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with TYW1B: view

Transcripts for TYW1B Gene

Unigene Clusters for TYW1B Gene

TRNA-yW synthesizing protein 1 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TYW1B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TYW1B Gene

No ASD Table

Relevant External Links for TYW1B Gene

GeneLoc Exon Structure for
TYW1B
ECgene alternative splicing isoforms for
TYW1B

Expression for TYW1B Gene

mRNA expression in normal human tissues for TYW1B Gene

Protein differential expression in normal tissues for TYW1B Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TYW1B Gene

SOURCE GeneReport for Unigene cluster for TYW1B Gene Hs.488614

genes like me logo Genes that share expressions with TYW1B: view

Expression partners for TYW1B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TYW1B Gene

Orthologs for TYW1B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TYW1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TYW1B 35
  • 98.71 (n)
  • 97.95 (a)
Species with no ortholog for TYW1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TYW1B Gene

ENSEMBL:
Gene Tree for TYW1B (if available)
TreeFam:
Gene Tree for TYW1B (if available)

Paralogs for TYW1B Gene

Selected SIMAP similar genes for TYW1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TYW1B: view

No data available for Paralogs for TYW1B Gene

Variants for TYW1B Gene

Sequence variations from dbSNP and Humsavar for TYW1B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1045946 -- 72,701,702(-) AATAA(A/G)CACAA intron-variant
rs1128732 -- 72,701,762(-) AGAGA(C/T)TTCAG intron-variant
rs1128734 -- 72,701,731(-) tatcg(A/G)attta intron-variant
rs1128736 -- 72,701,724(-) tttac(A/C)aaatt intron-variant
rs1133406 -- 72,727,006(-) gtgct(C/G)ttctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TYW1B Gene

Variant ID Type Subtype PubMed ID
dgv2094e1 CNV Complex 17122850
dgv2095e1 CNV Complex 17122850
nsv888347 CNV Gain 21882294
dgv2096e1 CNV Complex 17122850
dgv7322n71 CNV Gain 21882294
nsv888352 CNV Gain+Loss 21882294
nsv442053 CNV CNV 18776908
dgv1116n67 CNV Gain 20364138
esv33871 CNV Loss 17666407
nsv436901 CNV Insertion 17901297
dgv231e55 CNV Gain 17911159
dgv7323n71 CNV Loss 21882294
nsv888356 CNV Gain 21882294
nsv365909 CNV Loss 16902084
nsv5789 CNV Insertion 18451855
nsv888357 CNV Loss 21882294
nsv8131 CNV Loss 18304495
dgv821n27 CNV Gain 19166990
nsv520573 CNV Gain+Loss 19592680
esv34349 CNV Gain 17911159
esv25116 CNV Loss 19812545
nsv469716 CNV Gain 16826518
nsv888358 CNV Gain 21882294
nsv470310 CNV Gain 18288195
dgv62n64 CNV Gain 17921354
nsv888360 CNV Gain 21882294
dgv2097e1 CNV Complex 17122850
dgv2098e1 CNV Complex 17122850
nsv428171 CNV Gain 18775914
dgv2099e1 CNV Complex 17122850
nsv469793 CNV Gain 16826518
nsv5790 CNV Loss 18451855
nsv888361 CNV Gain 21882294
esv2666930 CNV Deletion 23128226
nsv8132 CNV Loss 18304495
esv2582277 CNV Loss 19546169
esv22305 CNV Loss 19812545
esv2604938 CNV Deletion 19546169
esv2202407 CNV Deletion 18987734
esv2734658 CNV Deletion 23290073
nsv499416 CNV Loss 21111241
nsv366245 CNV Loss 16902084
nsv888362 CNV Gain 21882294
esv2734659 CNV Deletion 23290073

Relevant External Links for TYW1B Gene

HapMap Linkage Disequilibrium report
TYW1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYW1B Gene

Disorders for TYW1B Gene

Relevant External Links for TYW1B

Genetic Association Database (GAD)
TYW1B
Human Genome Epidemiology (HuGE) Navigator
TYW1B

No disorders were found for TYW1B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TYW1B Gene

Publications for TYW1B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. (PMID: 16162496) Waas W.F. … Schimmel P. (J. Biol. Chem. 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TYW1B Gene

Sources for TYW1B Gene

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