Aliases for TYW1B Gene
- TRNA-YW Synthesizing Protein 1 Homolog B (S. Cerevisiae) 2 3
- Radical S-Adenosyl Methionine And Flavodoxin Domain-Containing Protein 2 3 4
- TRNA-YW Synthesizing Protein 1 Homolog B (Non-Protein Coding) 2 3
- Radical S-Adenosyl Methionine And Flavodoxin Domains 1 2 3
- TRNA Wybutosine-Synthesizing Protein 1 Homolog B 3 4
- Long Intergenic Non-Protein Coding RNA 69 2 3
- RSAFD2 3 4
External Ids for TYW1B Gene
Wybutosine is a hypermodified guanosine found in phenylalanine tRNA. Wybutosine functions to stabilize codon-anticodon interactions during ribosome decoding and therefore supports the maintenance of the reading frame. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. The human genome contains two closely related genes that putatively function in wybutosine synthesis. The open reading frame of this locus is disrupted in some individuals. Thus, this locus appears to be an evolving pseudogene, but may still be functional in some members of the population. [provided by RefSeq, Apr 2014]
GeneCards Summary for TYW1B Gene
TYW1B (TRNA-YW Synthesizing Protein 1 Homolog B (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and 4 iron, 4 sulfur cluster binding.
UniProtKB/Swiss-Prot for TYW1B Gene
Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).