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Aliases for TYW1 Gene

Aliases for TYW1 Gene

  • TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae) 2 3
  • Radical S-Adenosyl Methionine And Flavodoxin Domain-Containing Protein 1 3 4
  • Radical S-Adenosyl Methionine And Flavodoxin Domains 1 2 3
  • TRNA Wybutosine-Synthesizing Protein 1 Homolog 3 4
  • RSAFD1 3 4
  • S-Adenosyl-L-Methionine-Dependent TRNA 4-Demethylwyosine Synthase 3
  • TRNA-YW Synthesizing Protein 1 Homolog A (S. Cerevisiae) 2
  • TRNA-YW Synthesizing Protein 1 Homolog A 3
  • TRNA-YW-Synthesizing Protein 4
  • EC 4.1.3.44 4
  • YPL207W 3
  • TYW1A 3

External Ids for TYW1 Gene

Previous Symbols for TYW1 Gene

  • RSAFD1

Summaries for TYW1 Gene

Entrez Gene Summary for TYW1 Gene

  • Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. [provided by RefSeq, Dec 2012]

GeneCards Summary for TYW1 Gene

TYW1 (TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are wybutosine biosynthesis and wybutosine biosynthesis. GO annotations related to this gene include iron ion binding and 4 iron, 4 sulfur cluster binding.

UniProtKB/Swiss-Prot for TYW1 Gene

  • Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYW1 Gene

Genomics for TYW1 Gene

Genomic Location for TYW1 Gene

Start:
66,995,173 bp from pter
End:
67,239,520 bp from pter
Size:
244,348 bases
Orientation:
Plus strand

Genomic View for TYW1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TYW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYW1 Gene

Regulatory Elements for TYW1 Gene

Proteins for TYW1 Gene

  • Protein details for TYW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV66-TYW1_HUMAN
    Recommended name:
    S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
    Protein Accession:
    Q9NV66
    Secondary Accessions:
    • Q6PJG8
    • Q75MG8
    • Q75MN3
    • Q86V12
    • Q8IVS7
    • Q9H9C4

    Protein attributes for TYW1 Gene

    Size:
    732 amino acids
    Molecular mass:
    83702 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15591.1; Type=Frameshift; Positions=663; Evidence={ECO:0000305}; Sequence=BAB14307.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TYW1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TYW1 Gene

Proteomics data for TYW1 Gene at MOPED

Post-translational modifications for TYW1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TYW1 Gene

No data available for DME Specific Peptides for TYW1 Gene

Domains for TYW1 Gene

UniProtKB/Swiss-Prot:

TYW1_HUMAN
Domain:
  • Contains 1 flavodoxin-like domain.:
    • Q9NV66
Family:
  • Belongs to the TYW1 family.:
    • Q9NV66
genes like me logo Genes that share domains with TYW1: view

No data available for Gene Families for TYW1 Gene

Function for TYW1 Gene

Molecular function for TYW1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: N(1)-methylguanine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + L-methionine + 5-deoxyadenosine + CO(2) + H(2)O
UniProtKB/Swiss-Prot Function: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).

Enzyme Numbers (IUBMB) for TYW1 Gene

Gene Ontology (GO) - Molecular Function for TYW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005506 iron ion binding IEA --
GO:0010181 FMN binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with TYW1: view

miRNA for TYW1 Gene

miRTarBase miRNAs that target TYW1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TYW1 Gene

Localization for TYW1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TYW1 Gene COMPARTMENTS Subcellular localization image for TYW1 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TYW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TYW1: view

Pathways for TYW1 Gene

genes like me logo Genes that share pathways with TYW1: view

Pathways by source for TYW1 Gene

UniProtKB/Swiss-Prot Q9NV66-TYW1_HUMAN

  • Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis

Gene Ontology (GO) - Biological Process for TYW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with TYW1: view

Compounds for TYW1 Gene

(2) HMDB Compounds for TYW1 Gene

Compound Synonyms Cas Number PubMed IDs
Flavin Mononucleotide
  • FMN
146-17-8
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with TYW1: view

Transcripts for TYW1 Gene

Unigene Clusters for TYW1 Gene

TRNA-yW synthesizing protein 1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TYW1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1:
SP2:
SP3:
SP4: -

Relevant External Links for TYW1 Gene

GeneLoc Exon Structure for
TYW1
ECgene alternative splicing isoforms for
TYW1

Expression for TYW1 Gene

mRNA expression in normal human tissues for TYW1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TYW1 Gene

SOURCE GeneReport for Unigene cluster for TYW1 Gene Hs.520917

genes like me logo Genes that share expressions with TYW1: view

Orthologs for TYW1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TYW1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 96 (a)
OneToMany
TYW1 36
  • 98.94 (n)
  • 99.29 (a)
cow
(Bos Taurus)
Mammalia TYW1 36
  • 86.59 (n)
  • 86.05 (a)
TYW1 37
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 88 (a)
OneToMany
TYW1 36
  • 87.02 (n)
  • 87.02 (a)
mouse
(Mus musculus)
Mammalia Tyw1 36
  • 80.75 (n)
  • 81.87 (a)
Tyw1 16
Tyw1 37
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tyw1 36
  • 80.39 (n)
  • 82.46 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 70 (a)
OneToMany
TYW1 36
  • 76.65 (n)
  • 83.79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7207 36
tyw1 36
  • 69.43 (n)
  • 72.34 (a)
zebrafish
(Danio rerio)
Actinopterygii tyw1 36
  • 68.26 (n)
  • 71.07 (a)
tyw1 37
  • 67 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL099W 36
  • 52.57 (n)
  • 47.54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TYW1 36
  • 50.53 (n)
  • 46.89 (a)
TYW1 37
  • 33 (a)
OneToMany
TYW1 39
soybean
(Glycine max)
eudicotyledons Gma.17994 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G75200 36
  • 56.09 (n)
  • 54.2 (a)
rice
(Oryza sativa)
Liliopsida Os.33461 36
Os03g0775300 36
  • 56.72 (n)
  • 57.41 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06633 36
  • 50.48 (n)
  • 43.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1020.08 36
  • 55.49 (n)
  • 53.79 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5664 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8783 37
  • 57 (a)
OneToMany
Species with no ortholog for TYW1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TYW1 Gene

ENSEMBL:
Gene Tree for TYW1 (if available)
TreeFam:
Gene Tree for TYW1 (if available)

Paralogs for TYW1 Gene

Selected SIMAP similar genes for TYW1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TYW1 Gene

genes like me logo Genes that share paralogs with TYW1: view

No data available for Paralogs for TYW1 Gene

Variants for TYW1 Gene

Sequence variations from dbSNP and Humsavar for TYW1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs14318 -- 67,147,650(-) agtgg(G/T)agcta intron-variant
rs17726 -- 67,239,213(+) GCTGT(A/G)AGAGG utr-variant-3-prime, nc-transcript-variant
rs725485 -- 67,235,345(+) TCCCA(A/G)TTGGC intron-variant
rs1045053 -- 67,238,649(+) GAGAC(A/G)ATAAG utr-variant-3-prime, nc-transcript-variant
rs1045064 -- 67,238,882(+) AAGAA(A/G)TCCCT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TYW1 Gene

Variant ID Type Subtype PubMed ID
essv3137 CNV CNV 17122850
dgv2091e1 CNV Complex 17122850
esv23402 CNV Loss 19812545
nsv824151 CNV Loss 20364138
esv33653 CNV Loss 17666407
nsv888330 CNV Gain 21882294
nsv831019 CNV Loss 17160897
esv2467105 CNV Deletion 19546169
nsv5774 CNV Insertion 18451855
nsv509205 CNV Insertion 20534489
esv2422035 CNV Deletion 20811451
nsv441983 CNV CNV 18776908
esv2660507 CNV Deletion 23128226
esv2734604 CNV Deletion 23290073
esv2253832 CNV Deletion 18987734
esv2666250 CNV Deletion 23128226
esv26455 CNV Loss 19812545
dgv2092e1 CNV Complex 17122850

Relevant External Links for TYW1 Gene

HapMap Linkage Disequilibrium report
TYW1

Disorders for TYW1 Gene

Relevant External Links for TYW1

Genetic Association Database (GAD)
TYW1
Human Genome Epidemiology (HuGE) Navigator
TYW1
genes like me logo Genes that share disorders with TYW1: view

No data available for UniProtKB/Swiss-Prot for TYW1 Gene

Publications for TYW1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. (PMID: 16162496) Waas W.F. … Schimmel P. (J. Biol. Chem. 2005) 2 3

Products for TYW1 Gene

Sources for TYW1 Gene

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