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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TYW1 Gene

protein-coding GIFtS: 51
GCID: GC07P066460

TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae)

(Previous name: radical S-adenosyl methionine and flavodoxin domains 1)
(Previous symbol: RSAFD1)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae)¹ ²		TYW1A²
RSAFD1¹ ² ³		YPL207W²
Radical S-Adenosyl Methionine And Flavodoxin Domains 1¹ ²		TRNA Wybutosine-Synthesizing Protein 1 Homolog²
Radical S-Adenosyl Methionine And Flavodoxin Domain-Containing Protein 1² ³		TRNA-YW Synthesizing Protein 1 Homolog A²
TRNA-YW Synthesizing Protein 1 Homolog A (S. Cerevisiae)¹		TRNA-YW-Synthesizing Protein³

External Ids:	HGNC: 25598¹	Entrez Gene: 55253²	Ensembl: ENSG00000198874⁷	OMIM: 611243⁵	UniProtKB: Q9NV66³

Export aliases for TYW1 gene to outside databases

Previous GC identifers: GC07P066099 GC07P062645

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TYW1 Gene:

Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes

codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis

of wybutosine. (provided by RefSeq, Dec 2012)

GeneCards Summary for TYW1 Gene:

TYW1 (tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with TYW1 include fanconi's anemia, and cytochrome p450. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and iron ion binding.

UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66

Function: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with

a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By

similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NT_007933.15 NC_018918.2 NT_079593.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TYW1 gene promoter:
SRF Elk-1 SRF (504 AA) RREB-1 FOXO3 FOXO3b GATA-1 RORalpha1 STAT3 FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TYW1 promoter sequence

Search SABiosciences Chromatin IP Primers for TYW1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TYW1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21 Ensembl cytogenetic band: 7q11.21 HGNC cytogenetic band: 7q11.21

TYW1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TYW1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P066460: view genomic region (about GC identifiers)

Start:	66,460,160 bp from pter	End:	66,704,501 bp from pter
Size:	244,342 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 65,799,379-66,042,061

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66 (See protein sequence)

Recommended Name: tRNA wybutosine-synthesizing protein 1 homolog

Size: 732 amino acids; 83702 Da

Cofactor: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable

S-adenosyl-L-methionine (By similarity)

Sequence caution: Sequence=AAH15591.1; Type=Frameshift; Positions=663; Sequence=BAB14307.1; Type=Erroneous

initiation;

Secondary accessions: Q6PJG8 Q75MG8 Q75MN3 Q86V12 Q8IVS7 Q9H9C4

Alternative splicing: 2 isoforms: Q9NV66-1 Q9NV66-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TYW1: NX_Q9NV66

Explore proteomics data for TYW1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9NV66

TYW1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_060734.2

ENSEMBL proteins:

ENSP00000352645 ENSP00000398897 ENSP00000354795

Human Recombinant Protein Products for TYW1:

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	Cloud-Clone Corp. ELISAs for TYW1 Cloud-Clone Corp. CLIAs for TYW1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5 InterPro protein domains:

IPR013785 Aldolase_TIM

IPR001094 Flavdoxin

IPR008254 Flavodoxin/NO_synth

IPR007197 rSAM

IPR013917 tRNA_wybutosine-synth

Graphical View of Domain Structure for InterPro Entry Q9NV66

ProtoNet protein and cluster: Q9NV66

3 Blocks protein domains:

IPB001094 Flavodoxin signature

IPB008254 Flavodoxin/nitric oxide synthase

IPB013917 Wyosine base formation

UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66

Similarity: Belongs to the TYW1 family

Similarity: Contains 1 flavodoxin-like domain

TYW1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TYW1_HUMAN, Q9NV66

Function: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with

a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By

similarity)

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0005506	iron ion binding	IEA	--
GO:0010181	FMN binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0051536	iron-sulfur cluster binding	--	--

TYW1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for TYW1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TYW1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TYW1

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		SwitchGear 3'UTR luciferase reporter plasmid: TYW1 3' UTR sequence

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TYW1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYW1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66

Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TYW1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/31 Interacting proteins for TYW1 (Q9NV66³ ENSP00000352645⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRWD1	Q9BQ67³, ENSP00000253237⁴	I2D: score=2 STRING: ENSP00000253237
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=2 STRING: ENSP00000344818
PWP1	Q13610³	I2D: score=4
HSP90AA1	P07900³	I2D: score=3
HSPA9	P38646³	I2D: score=2

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008033	tRNA processing	IEA	--

TYW1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TYW1

2 HMDB Compounds for TYW1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Flavin Mononucleotide	FMN (see all 19)	146-17-8	--
S-Adenosylmethionine	(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)	29908-03-0	--

Search CenterWatch for drugs/clinical trials and news about TYW1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TYW1 gene:

NM_018264.3

Unigene Cluster for TYW1:

TRNA-yW synthesizing protein 1 homolog (S. cerevisiae)

Hs.520917 [show with all ESTs]

Unigene Representative Sequence: NM_018264

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000491969 ENST00000359626(uc003tvn.3 uc010lai.3) ENST00000442959

ENST00000475392 ENST00000361660 ENST00000495971

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TYW1
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate TYW1:
		hsa-miR-549 hsa-miR-148b* hsa-miR-2355-3p hsa-miR-3672
		SwitchGear 3'UTR luciferase reporter plasmid: TYW1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional mRNA sequence:

AK001762.1 AK022917.1 AK301330.1 BC015591.2 BC042156.1 BC051888.1

12 DOTS entries:

DT.100789029 DT.99933881 DT.316409 DT.100774174 DT.423111 DT.105466 DT.92435437 DT.95370849

DT.100776166 DT.100789030 DT.95256568 DT.100674468

24/167 AceView cDNA sequences (see all 167):

BF434912 AU122057 BM768300 AA653716 BP377738 AI913520 NM_018264 AI380108

BU628109 AA115040 AI277061 BM989121 AI073929 BU633885 AI922049 BP428538

BX112421 CB306182 CA454298 AI745344 AA115497 AA114967 BC042156 CA314911

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TYW1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b
SP1:
SP2:
SP3:
SP4:																									-

ECgene alternative splicing isoforms for TYW1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TYW1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

See TYW1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TYW1

SOURCE GeneReport for Unigene cluster: Hs.520917

SABiosciences Custom PCR Arrays for TYW1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TYW1 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Tyw1^{1 , 5}	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) less^{1, 5}	80.52(n)¹ 81.87(a)¹	5 (69.00 cM)⁵ 100929¹ NM_001015876.2¹ NP_001015876.1¹ 130255619⁵
chicken (Gallus gallus)	Aves	TYW1¹	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) less	76.65(n) 83.79(a)	417478 XM_003642390.1 XP_003642438.1
African clawed frog (Xenopus laevis)	Amphibia	CA788486.1²	--	78.51(n)	CA788486.1
zebrafish (Danio rerio)	Actinopterygii	tyw1¹	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) less	68.5(n) 71.23(a)	562076 NM_001077156.1 NP_001070624.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TYW1(YPL207W)⁴ TYW1¹	Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions less⁴ Tyw1p¹	50.92(n)¹ 47.39(a)¹	16(159909-162341)⁴ 855894^{1, 4} NP_015117.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G75200¹	tRNA wybutosine-synthesizing protein 1-like protein less	56.38(n) 54.2(a)	843857 NM_106176.5 NP_177656.2
rice (Oryza sativa)	Liliopsida	Os.33461²	Oryza sativa (japonica cultivar-group) cDNA cloneJ023099L20, full insert sequence less	76.77(n)	AK100507.1

ENSEMBL Gene Tree for TYW1 (if available)
TreeFam Gene Tree for TYW1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TYW1 gene

1 SIMAP similar gene for TYW1 using alignment to 2 protein entries: TYW1_HUMAN (see all proteins):

TYW1B

TYW1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for TYW1
PGOHUM00000250454 PGOHUM00000250873

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_031290⁴		--	--	see VAR_031290	2	D N	mis⁴		0	--	--	--	--
rs4718439^1,2	C,F,A,H	--	65800229(+)	`CTGGAG/ATGCGG`	1	--	int¹		8		NS EA NA WA	412
rs4718440^1,2	C,F,A,H	--	65800241(+)	`GGCGCA/GATCTT`	1	--	int¹		4		NA WA	8
rs146670995^1,2		--	65800338(+)	`ACGCCC/TGGCTA`	1	--	int¹		0	--	--	--	--
rs11770114^1,2	C,H	--	65800350(+)	`tttttA/Gtattt`	1	--	int¹		0	--	--	--	--
rs186274509^1,2		--	65800443(+)	`AAAGTA/GCTGGA`	1	--	int¹		0	--	--	--	--
rs192510151^1,2		--	65800475(+)	`GCCCGG/TCCAAC`	1	--	int¹		0	--	--	--	--
rs114797515^1,2	F	--	65800556(+)	`TTGGGA/GTGGAT`	1	--	int¹		1		WA	118
rs138394993^1,2	F	--	65800630(+)	`GATACA/GTGGGA`	2	T	syn¹		1		NA	4542
rs201637088^1,2		--	65800732(+)	`ATTGTA/CATCAA`	2	V	syn¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TYW1 (66460160 - 66704501 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/18 variations for TYW1 (see all 18): About this table

Variant ID	Type	Subtype	PubMed ID
esv2253832	CNV	Deletion	18987734
esv2734604	CNV	Deletion	23290073
esv2467105	CNV	Deletion	19546169
esv2422035	CNV	Deletion	20811451
esv2666250	CNV	Deletion	23128226
esv2660507	CNV	Deletion	23128226
nsv509205	CNV	Insertion	20534489
nsv5774	CNV	Insertion	18451855
nsv824151	CNV	Loss	20364138
esv33653	CNV	Loss	17666407

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing TYW1

DNA2.0 Custom Variant and Variant Library Synthesis for TYW1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 611243 OMIM disorders: --

3 diseases for TYW1: About MalaCards

fanconi's anemia cytochrome p450 anemia

TYW1 for disorders About GeneDecksing

Genetic Association Database (GAD): TYW1
Human Genome Epidemiology (HuGE) Navigator: TYW1 (1 document)

Export disorders for TYW1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TYW1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TYW1)

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Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. (PubMed id 17150819)^{1, 3} Noma A. and Suzuki T. (2006)
Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. (PubMed id 16162496)^{1, 3} Waas W.F....Schimmel P. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)¹ Zhu J....Elledge S.J. (2013)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)¹ Stehling O....Lill R. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55253	HGNC: 25598	AceView: FLJ10900	Ensembl:ENSG00000198874	euGenes: HUgn55253
ECgene: TYW1	H-InvDB: TYW1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TYW1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TYW1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TYW1 gene:
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TYW1 Gene

TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae)

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TYW1 Gene

TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae)

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