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TYW1 Gene

protein-coding GIFtS: 53
GCID: GC07P066460

TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae)

(Previous name: radical S-adenosyl methionine and flavodoxin domains 1)
(Previous symbol: RSAFD1)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae)¹ ²		TYW1A²
RSAFD1¹ ² ³		YPL207W²
Radical S-Adenosyl Methionine And Flavodoxin Domains 1¹ ²		S-Adenosyl-L-Methionine-Dependent TRNA 4-Demethylwyosine Synthase²
Radical S-Adenosyl Methionine And Flavodoxin Domain-Containing Protein 1² ³		TRNA-YW Synthesizing Protein 1 Homolog A²
TRNA Wybutosine-Synthesizing Protein 1 Homolog² ³		EC 4.1.3.44³
TRNA-YW Synthesizing Protein 1 Homolog A (S. Cerevisiae)¹		TRNA-YW-Synthesizing Protein³

External Ids:	HGNC: 25598¹	Entrez Gene: 55253²	Ensembl: ENSG00000198874⁷	OMIM: 611243⁵	UniProtKB: Q9NV66³

Export aliases for TYW1 gene to outside databases

Previous GC identifers: GC07P066099 GC07P062645

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TYW1 Gene:

Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes

codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis

of wybutosine. (provided by RefSeq, Dec 2012)

GeneCards Summary for TYW1 Gene:

TYW1 (tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and iron ion binding. An important paralog of this gene is TYW1B.

UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66

Function: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with

a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes

the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an

intermediate in wybutosine biosynthesis (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000007.13 NT_007933.16 NC_018918.2

Regulatory elements:

Regulatory transcription factor binding sites in the TYW1 gene promoter:
SRF Elk-1 SRF (504 AA) RREB-1 FOXO3 FOXO3b GATA-1 RORalpha1 STAT3 FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TYW1 promoter sequence

Search Chromatin IP Primers for TYW1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TYW1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21 Ensembl cytogenetic band: 7q11.21 HGNC cytogenetic band: 7q11.21

TYW1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TYW1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P066460: view genomic region (about GC identifiers)

Start:	66,460,160 bp from pter	End:	66,704,501 bp from pter
Size:	244,342 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 65,799,379-66,042,061

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66 (See protein sequence)

Recommended Name: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

Size: 732 amino acids; 83702 Da

Cofactor: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable

S-adenosyl-L-methionine (By similarity)

Sequence caution: Sequence=AAH15591.1; Type=Frameshift; Positions=663; Sequence=BAB14307.1; Type=Erroneous

initiation;

Secondary accessions: Q6PJG8 Q75MG8 Q75MN3 Q86V12 Q8IVS7 Q9H9C4

Alternative splicing: 2 isoforms: Q9NV66-1 Q9NV66-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TYW1: NX_Q9NV66

Explore proteomics data for TYW1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See TYW1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060734.2

ENSEMBL proteins:

ENSP00000352645 ENSP00000398897 ENSP00000354795

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

5 InterPro protein domains:

IPR013785 Aldolase_TIM

IPR001094 Flavdoxin

IPR008254 Flavodoxin/NO_synth

IPR007197 rSAM

IPR013917 tRNA_wybutosine-synth

Graphical View of Domain Structure for InterPro Entry Q9NV66

ProtoNet protein and cluster: Q9NV66

3 Blocks protein domains:

IPB001094 Flavodoxin signature

IPB008254 Flavodoxin/nitric oxide synthase

IPB013917 Wyosine base formation

UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66

Similarity: Belongs to the TYW1 family

Similarity: Contains 1 flavodoxin-like domain

Find genes that share domains with TYW1 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TYW1_HUMAN, Q9NV66

Function: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with

a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes

the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an

intermediate in wybutosine biosynthesis (By similarity)

Catalytic activity: N(1)-methylguanine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine =

4-demethylwyosine(37) in tRNA(Phe) + L-methionine + 5'-deoxyadenosine + CO(2) + H(2)O

Enzyme Number (IUBMB): EC 4.1.3.44¹

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0005506	iron ion binding	IEA	--
GO:0010181	FMN binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0016829	lyase activity	IEA	--

Find genes that share ontologies with TYW1 About GenesLikeMe

Animal Models:

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	2
endoplasmic reticulum	1
extracellular	1
golgi apparatus	1
nucleus	1
peroxisome	1
plasma membrane	1

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

Find genes that share ontologies with TYW1 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for TYW1 About

See pathways by source

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by

SuperPath

Contained pathways About

wybutosine biosynthesis

7-(3-amino-3-carboxypropyl)-wyosine biosynthesis

0.00

wybutosine biosynthesis

2 BioSystems Pathways for TYW1

	wybutosine biosynthesis
	7-(3-amino-3-carboxypropyl)-wyosine biosynthesis

UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66

Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for TYW1
Interactions:

Search GeneGlobe Interaction Network for TYW1

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

Selected Interacting proteins for TYW1 (Q9NV66³ ENSP00000352645⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 39)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRWD1	Q9BQ67³, ENSP00000253237⁴	I2D: score=2 STRING: ENSP00000253237
EIF5A	P63241³, ENSP00000336702⁴	I2D: score=1 STRING: ENSP00000336702
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=2 STRING: ENSP00000344818
PWP1	Q13610³	I2D: score=4
HSP90AA1	P07900³	I2D: score=3

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008033	tRNA processing	IEA	--

Find genes that share ontologies with TYW1 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for TYW1

2 HMDB Compounds for TYW1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Flavin Mononucleotide	FMN (see all 19)	146-17-8	--
S-Adenosylmethionine	(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)	29908-03-0	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for TYW1 gene:

NM_018264.3

Unigene Cluster for TYW1:

TRNA-yW synthesizing protein 1 homolog (S. cerevisiae)

Hs.520917 [show with all ESTs]

Unigene Representative Sequence: NM_018264

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000491969 ENST00000359626(uc003tvn.3 uc010lai.3) ENST00000442959

ENST00000475392 ENST00000361660 ENST00000495971

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Additional mRNA sequence:

AK001762.1 AK022917.1 AK301330.1 BC015591.2 BC042156.1 BC051888.1

12 DOTS entries:

DT.100789029 DT.99933881 DT.316409 DT.100774174 DT.423111 DT.105466 DT.92435437 DT.95370849

DT.100776166 DT.100789030 DT.95256568 DT.100674468

Selected AceView cDNA sequences (see all 167):

AA114967 AI073929 BM768300 AI745344 BU633885 AA115497 BC051888 NM_018264

BU628109 AA115040 BC042156 CB306182 BF434912 CD369837 BQ221024 AA953059

AI273336 BX112421 AA653716 AU122057 AI277061 BM989121 AA115025 AA582390

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TYW1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b
SP1:
SP2:
SP3:
SP4:																									-

ECgene alternative splicing isoforms for TYW1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TYW1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

TYW1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TYW1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.520917

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TYW1 gene from Selected species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Tyw1^{1 , 5}	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) less^{1, 5}	80.75(n)¹ 81.87(a)¹	5 (69.00 cM)⁵ 100929¹ NM_001015876.2¹ NP_001015876.1¹ 130255619⁵
chicken (Gallus gallus)	Aves	TYW1¹	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) less	76.65(n) 83.79(a)	417478 XM_003642390.2 XP_003642438.1
African clawed frog (Xenopus laevis)	Amphibia	CA788486.1²	--	78.51(n)	CA788486.1
zebrafish (Danio rerio)	Actinopterygii	tyw1¹	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) less	68.26(n) 71.07(a)	562076 NM_001077156.1 NP_001070624.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TYW1(YPL207W)⁴ TYW1¹	Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions less⁴ TYW1¹	50.53(n)¹ 46.89(a)¹	16(159909-162341)⁴ 855894^{1, 4} NP_015117.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G75200¹	AT1G75200	56.09(n) 54.2(a)	843857 NM_106176.5 NP_177656.2
rice (Oryza sativa)	Liliopsida	Os.33461²	Oryza sativa (japonica cultivar-group) cDNA cloneJ023099L20, full insert sequence less	76.77(n)	AK100507.1

ENSEMBL Gene Tree for TYW1 (if available)
TreeFam Gene Tree for TYW1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for TYW1 gene

TYW1B²

1 SIMAP similar gene for TYW1 using alignment to 2 protein entries: TYW1_HUMAN (see all proteins):

TYW1B

Find genes that share paralogs with TYW1 About GenesLikeMe

2 Pseudogenes.org Pseudogenes for TYW1
PGOHUM00000250454 PGOHUM00000250873

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4718439^1,2	C,F,A,H	--	65800229(+)	`CTGGAG/ATGCGG`	1	--	int¹		8		NS EA NA WA	412
rs4718440^1,2	C,F,A,H	--	65800241(+)	`GGCGCA/GATCTT`	1	--	int¹		4		NA WA	8
rs146670995^1,2		--	65800338(+)	`ACGCCC/TGGCTA`	1	--	int¹		0	--	--	--	--
rs11770114^1,2	C,H	--	65800350(+)	`tttttA/Gtattt`	1	--	int¹		0	--	--	--	--
rs186274509^1,2		--	65800443(+)	`AAAGTA/GCTGGA`	1	--	int¹		0	--	--	--	--
rs192510151^1,2		--	65800475(+)	`GCCCGG/TCCAAC`	1	--	int¹		0	--	--	--	--
rs114797515^1,2	F	--	65800556(+)	`TTGGGA/GTGGAT`	1	--	int¹		1		WA	118
rs138394993^1,2	F	--	65800630(+)	`GATACA/GTGGGA`	2	T	syn¹		1		NA	4542
rs201637088^1,2		--	65800732(+)	`ATTGTA/CATCAA`	2	V	syn¹		0	--	--	--	--
rs147995512^1,2	C,F	--	65800740(+)	`CAAGAC/TGCAGG`	2	T M	mis¹		2		NA EU	5873

HapMap Linkage Disequilibrium report for TYW1 (66460160 - 66704501 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for TYW1 (see all 18): About this table

Variant ID	Type	Subtype	PubMed ID
esv2253832	CNV	Deletion	18987734
esv2734604	CNV	Deletion	23290073
esv2467105	CNV	Deletion	19546169
esv2422035	CNV	Deletion	20811451
esv2666250	CNV	Deletion	23128226
esv2660507	CNV	Deletion	23128226
nsv509205	CNV	Insertion	20534489
nsv5774	CNV	Insertion	18451855
nsv824151	CNV	Loss	20364138
esv33653	CNV	Loss	17666407

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 611243 OMIM disorders: --

Find genes that share disorders with TYW1 About GenesLikeMe

Genetic Association Database (GAD): TYW1
Human Genome Epidemiology (HuGE) Navigator: TYW1 (1 document)

Export disorders for TYW1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TYW1 gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with TYW1)

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. (PubMed id 17150819)^{1, 3} Noma A. and Suzuki T. (Nucleic Acids Symp Ser (Oxf) 2006)
Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. (PubMed id 16162496)^{1, 3} Waas W.F....Schimmel P. (J. Biol. Chem. 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (Nature 2003)
Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)¹ Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)¹ Stehling O.... Lill R. (Science 2012)
Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55253	HGNC: 25598	AceView: FLJ10900	Ensembl:ENSG00000198874	euGenes: HUgn55253
ECgene: TYW1	H-InvDB: TYW1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TYW1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TYW1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TYW1 gene:
Search GeneIP for patents involving TYW1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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TYW1 Gene

TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae)

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TYW1 Gene

TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae)

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