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TYW1 Gene

protein-coding   GIFtS: 53
GCID: GC07P066460

TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae)

(Previous name: radical S-adenosyl methionine and flavodoxin domains 1)
(Previous symbol: RSAFD1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae)1 2     TYW1A2
RSAFD11 2 3     YPL207W2
Radical S-Adenosyl Methionine And Flavodoxin Domains 11 2     S-Adenosyl-L-Methionine-Dependent TRNA 4-Demethylwyosine Synthase2
Radical S-Adenosyl Methionine And Flavodoxin Domain-Containing Protein 12 3     TRNA-YW Synthesizing Protein 1 Homolog A2
TRNA Wybutosine-Synthesizing Protein 1 Homolog2 3     EC 4.1.3.443
TRNA-YW Synthesizing Protein 1 Homolog A (S. Cerevisiae)1     TRNA-YW-Synthesizing Protein3

External Ids:    HGNC: 255981   Entrez Gene: 552532   Ensembl: ENSG000001988747   OMIM: 6112435   UniProtKB: Q9NV663   

Export aliases for TYW1 gene to outside databases

Previous GC identifers: GC07P066099 GC07P062645


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TYW1 Gene:
Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes
codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis
of wybutosine. (provided by RefSeq, Dec 2012)

GeneCards Summary for TYW1 Gene:
TYW1 (tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with TYW1 include fanconi's anemia. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and iron ion binding. An important paralog of this gene is TYW1B.

UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66
Function: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with
a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes
the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an
intermediate in wybutosine biosynthesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TYW1 gene promoter:
         SRF   Elk-1   SRF (504 AA)   RREB-1   FOXO3   FOXO3b   GATA-1   RORalpha1   STAT3   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TYW1 promoter sequence
   Search Chromatin IP Primers for TYW1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TYW1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7q11.21

TYW1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TYW1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P066460:  view genomic region     (about GC identifiers)

Start:
66,460,160 bp from pter      End:
66,704,501 bp from pter
Size:
244,342 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 65,799,379-66,042,061     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66 (See protein sequence)
Recommended Name: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase  
Size: 732 amino acids; 83702 Da
Cofactor: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable
S-adenosyl-L-methionine (By similarity)
Sequence caution: Sequence=AAH15591.1; Type=Frameshift; Positions=663; Sequence=BAB14307.1; Type=Erroneous
initiation;
Secondary accessions: Q6PJG8 Q75MG8 Q75MN3 Q86V12 Q8IVS7 Q9H9C4
Alternative splicing: 2 isoforms:  Q9NV66-1   Q9NV66-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TYW1: NX_Q9NV66

Explore proteomics data for TYW1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TYW1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060734.2  
    ENSEMBL proteins: 
     ENSP00000352645   ENSP00000398897   ENSP00000354795  

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    Cloud-Clone Corp. CLIAs for TYW1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR001094 Flavdoxin
     IPR008254 Flavodoxin/NO_synth
     IPR007197 rSAM
     IPR013917 tRNA_wybutosine-synth

    Graphical View of Domain Structure for InterPro Entry Q9NV66

    ProtoNet protein and cluster: Q9NV66

    3 Blocks protein domains:
    IPB001094 Flavodoxin signature
    IPB008254 Flavodoxin/nitric oxide synthase
    IPB013917 Wyosine base formation


    UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66
    Similarity: Belongs to the TYW1 family
    Similarity: Contains 1 flavodoxin-like domain


    TYW1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYW1_HUMAN, Q9NV66
    Function: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with
    a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes
    the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an
    intermediate in wybutosine biosynthesis (By similarity)
    Catalytic activity: N(1)-methylguanine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine =
    4-demethylwyosine(37) in tRNA(Phe) + L-methionine + 5'-deoxyadenosine + CO(2) + H(2)O

         Enzyme Number (IUBMB): EC 4.1.3.441

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005506iron ion binding IEA--
    GO:0010181FMN binding IEA--
    GO:0016491oxidoreductase activity IEA--
    GO:0016829lyase activity IEA--
         
    TYW1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TYW1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TYW1

    miRNA
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    miRTarBase miRNAs that target TYW1:
    hsa-mir-26a-5p (MIRT050089)

    Block miRNA regulation of human, mouse, rat TYW1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TYW1:
    hsa-miR-549 hsa-miR-148b* hsa-miR-2355-3p hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmidTYW1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TYW1

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    GenScript: all cDNA clones in your preferred vector: TYW1 (NM_018264)
    Sino Biological Human cDNA Clone for TYW1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TYW1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYW1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYW1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    TYW1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TYW1 About    
    See pathways by source

    SuperPathContained pathways About
    1wybutosine biosynthesis
    7-(3-amino-3-carboxypropyl)-wyosine biosynthesis0.00
    wybutosine biosynthesis


    2 BioSystems Pathways for TYW1
        wybutosine biosynthesis
    7-(3-amino-3-carboxypropyl)-wyosine biosynthesis



    UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66
    Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TYW1
    Interactions:

        Search GeneGlobe Interaction Network for TYW1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for TYW1 (Q9NV663 ENSP000003526454) via UniProtKB, MINT, STRING, and/or I2D (see all 39)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRWD1Q9BQ673, ENSP000002532374I2D: score=2 STRING: ENSP00000253237
    EIF5AP632413, ENSP000003367024I2D: score=1 STRING: ENSP00000336702
    UBCP0CG483, ENSP000003448184I2D: score=2 STRING: ENSP00000344818
    PWP1Q136103I2D: score=4 
    HSP90AA1P079003I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008033tRNA processing IEA--

    TYW1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TYW1

    2 HMDB Compounds for TYW1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Flavin MononucleotideFMN (see all 19)146-17-8--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TYW1 gene: 
    NM_018264.3  

    Unigene Cluster for TYW1:

    TRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
    Hs.520917  [show with all ESTs]
    Unigene Representative Sequence: NM_018264
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491969 ENST00000359626(uc003tvn.3 uc010lai.3) ENST00000442959
    ENST00000475392 ENST00000361660 ENST00000495971
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TYW1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TYW1:
    hsa-miR-549 hsa-miR-148b* hsa-miR-2355-3p hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmidTYW1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TYW1
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    GenScript: all cDNA clones in your preferred vector: TYW1 (NM_018264)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TYW1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYW1
    Primer
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    OriGene qPCR primer pairs and template standards for TYW1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TYW1
      QuantiTect SYBR Green Assays in human, mouse, rat TYW1
      QuantiFast Probe-based Assays in human, mouse, rat TYW1

    Additional mRNA sequence: 

    AK001762.1 AK022917.1 AK301330.1 BC015591.2 BC042156.1 BC051888.1 

    12 DOTS entries:

    DT.100789029  DT.99933881  DT.316409  DT.100774174  DT.423111  DT.105466  DT.92435437  DT.95370849 
    DT.100776166  DT.100789030  DT.95256568  DT.100674468 

    Selected AceView cDNA sequences (see all 167):

    AA114967 AI073929 BM768300 AI745344 BU633885 AA115497 BC051888 NM_018264 
    BU628109 AA115040 BC042156 CB306182 BF434912 CD369837 BQ221024 AA953059 
    AI273336 BX112421 AA653716 AU122057 AI277061 BM989121 AA115025 AA582390 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TYW1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                          -               


    ECgene alternative splicing isoforms for TYW1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TYW1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TYW1 Expression
    About this image

    TYW1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TYW1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520917
        Custom PCR Arrays for TYW1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYW1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TYW1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tyw11 , 5 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) less1, 5 80.75(n)1
    81.87(a)1
      5 (69.00 cM)5
    1009291  NM_001015876.21  NP_001015876.11 
     1302556195 
    chicken
    (Gallus gallus)
    Aves TYW11 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) less 76.65(n)
    83.79(a)
      417478  XM_003642390.2  XP_003642438.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia CA788486.12   -- 78.51(n)    CA788486.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tyw11 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) less 68.26(n)
    71.07(a)
      562076  NM_001077156.1  NP_001070624.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TYW1(YPL207W)4
    TYW11
    Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions less4
    TYW11
    50.53(n)1
    46.89(a)1
      16(159909-162341)4
    8558941, 4  NP_015117.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G752001 AT1G75200 56.09(n)
    54.2(a)
      843857  NM_106176.5  NP_177656.2 
    rice
    (Oryza sativa)
    Liliopsida Os.334612 Oryza sativa (japonica cultivar-group) cDNA cloneJ023099L20, full insert sequence less 76.77(n)    AK100507.1 


    ENSEMBL Gene Tree for TYW1 (if available)
    TreeFam Gene Tree for TYW1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TYW1 gene
    TYW1B2  
    1 SIMAP similar gene for TYW1 using alignment to 2 protein entries:     TYW1_HUMAN (see all proteins):
    TYW1B

    TYW1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TYW1
    PGOHUM00000250454 PGOHUM00000250873


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TYW1 (see all 6045)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47184391,2
    C,F,A,H--65800229(+) CTGGAG/ATGCGG 1 -- int18Minor allele frequency- A:0.01NS EA NA WA 412
    rs47184401,2
    C,F,A,H--65800241(+) GGCGCA/GATCTT 1 -- int14Minor allele frequency- G:0.38NA WA 8
    rs1466709951,2
    --65800338(+) ACGCCC/TGGCTA 1 -- int10--------
    rs117701141,2
    C,H--65800350(+) tttttA/Gtattt 1 -- int10--------
    rs1862745091,2
    --65800443(+) AAAGTA/GCTGGA 1 -- int10--------
    rs1925101511,2
    --65800475(+) GCCCGG/TCCAAC 1 -- int10--------
    rs1147975151,2
    F--65800556(+) TTGGGA/GTGGAT 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1383949931,2
    F--65800630(+) GATACA/GTGGGA 2 T syn11Minor allele frequency- G:0.00NA 4542
    rs2016370881,2
    --65800732(+) ATTGTA/CATCAA 2 V syn10--------
    rs1479955121,2
    C,F--65800740(+) CAAGAC/TGCAGG 2 T M mis12Minor allele frequency- T:0.00NA EU 5873

    HapMap Linkage Disequilibrium report for TYW1 (66460160 - 66704501 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TYW1 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2253832CNV Deletion18987734
    esv2734604CNV Deletion23290073
    esv2467105CNV Deletion19546169
    esv2422035CNV Deletion20811451
    esv2666250CNV Deletion23128226
    esv2660507CNV Deletion23128226
    nsv509205CNV Insertion20534489
    nsv5774CNV Insertion18451855
    nsv824151CNV Loss20364138
    esv33653CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 611243    OMIM disorders: --

    1 disease for TYW1:    
    About MalaCards
    fanconi's anemia


    TYW1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TYW1
    Human Genome Epidemiology (HuGE) Navigator: TYW1 (1 document)

    Export disorders for TYW1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TYW1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TYW1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. (PubMed id 17150819)1, 3 Noma A. and Suzuki T. (Nucleic Acids Symp Ser (Oxf) 2006)
    3. Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. (PubMed id 16162496)1, 3 Waas W.F....Schimmel P. (J. Biol. Chem. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 55253 HGNC: 25598 AceView: FLJ10900 Ensembl:ENSG00000198874 euGenes: HUgn55253
    ECgene: TYW1 H-InvDB: TYW1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TYW1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TYW1 gene:
    Search GeneIP for patents involving TYW1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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