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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TYW1 Gene

protein-coding   GIFtS: 49
GCID: GC07P066460

tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)

(Previous name: radical S-adenosyl methionine and flavodoxin domains 1...)
(Previous symbol: RSAFD1)
 Explore 4 diseases affiliated with
TYW1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TYW1    

Aliases
for TYW1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
TRNA-YW Synthesizing Protein 1 Homolog (S. Cerevisiae)1 2     FLJ109001
RSAFD11 2 3     MGC230011
TYW1A1 2     MGC602911
YPL207W1 2     TRNA Wybutosine-Synthesizing Protein 1 Homolog2
Radical S-Adenosyl Methionine And Flavodoxin Domains 11 2     TRNA-YW Synthesizing Protein 1 Homolog A2
Radical S-Adenosyl Methionine And Flavodoxin Domain-Containing Protein 12 3     TRNA-YW-Synthesizing Protein3

External Ids:    HGNC: 255981   Entrez Gene: 552532   Ensembl: ENSG000001988747   OMIM: 6112435   UniProtKB: Q9NV663   

Export aliases for TYW1 gene to outside databases

Previous GC identifers: GC07P066099 GC07P062645


Summaries
for TYW1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TYW1:
Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes
codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of
wybutosine. (provided by RefSeq, Dec 2012)

UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66
Function: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a
tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity)




Genomic Views
for TYW1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079593.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TYW1 gene promoter:
         SRF   Elk-1   SRF (504 AA)   RREB-1   FOXO3   FOXO3b   GATA-1   RORalpha1   STAT3   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TYW1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TYW1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TYW1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7q11.21

TYW1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TYW1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P066460:  view genomic region     (about GC identifiers)

Start:
 66,460,160 bp from pter      End:
 66,704,501 bp from pter
Size:
 244,342 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 65,799,379-66,042,061     

Proteins
for TYW1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66 (See protein sequence)
Recommended Name: tRNA wybutosine-synthesizing protein 1 homolog  
Size: 732 amino acids; 83702 Da
Cofactor: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable
S-adenosyl-L-methionine (By similarity)
Sequence caution: Sequence=AAH15591.1; Type=Frameshift; Positions=663; Sequence=BAB14307.1; Type=Erroneous initiation;
Secondary accessions: Q6PJG8 Q75MG8 Q75MN3 Q86V12 Q8IVS7 Q9H9C4
Alternative splicing: 2 isoforms:  Q9NV66-1   Q9NV66-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TYW1: NX_Q9NV66

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NV66

    • TYW1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060734.2  
    ENSEMBL proteins: 
     ENSP00000352645   ENSP00000398897   ENSP00000354795   ENSP00000373848   ENSP00000403564  
     ENSP00000414367  

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    Novus Biologicals TYW1 Proteins
    Novus Biologicals TYW1 Lysates
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    Uscn Proteins for TYW1


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    ThermoFisher Antibodies for TYW1

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    Uscn ELISAs and CLIAs for TYW1

    Protein Domains /
    Families
    for TYW1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TYW1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR013785 Aldolase_TIM
     IPR001094 Flavdoxin
     IPR008254 Flavodoxin/NO_synth
     IPR007197 rSAM
     IPR013917 tRNA_wybutosine-synth

    Graphical View of Domain Structure for InterPro Entry Q9NV66

    ProtoNet protein and cluster: Q9NV66

    3 Blocks protein families:
    IPB001094 Flavodoxin signature
    IPB008254 Flavodoxin/nitric oxide synthase
    IPB013917 Wyosine base formation


    UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66
    Similarity: Belongs to the TYW1 family
    Similarity: Contains 1 flavodoxin-like domain


    Function
    for TYW1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66
    Function: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a
    tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TYW1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TYW1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TYW1:
    hsa-miR-549 hsa-miR-148b* hsa-miR-2355-3p hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmid: TYW1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TYW1 (see all 7)
    OriGene shRNA RFP: TYW1
    OriGene siRNA: TYW1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TYW1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TYW1

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for TYW1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYW1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0010181FMN binding IEA--
    GO:0016491oxidoreductase activity IEA--
    GO:00515394 iron, 4 sulfur cluster binding IEA--


    TYW1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TYW1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: TYW1_HUMAN, Q9NV66
    Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TYW1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/30 Interacting proteins for TYW1 (Q9NV663 ENSP000003526454) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRWD1Q9BQ673, ENSP000002532374I2D: score=2 STRING: ENSP00000253237
    UBCP0CG483, ENSP000003448184I2D: score=2 STRING: ENSP00000344818
    PWP1Q136103, ENSP000002585314I2D: score=4 STRING: ENSP00000258531
    HSP90AA1P079003I2D: score=3 
    HSPA9P386463I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008033tRNA processing IEA--


    TYW1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TYW1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TYW1

    2 HMDB Compounds for TYW1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Flavin MononucleotideFMN (see all 19)146-17-8--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Search CenterWatch for drugs/clinical trials and news about TYW1 

    Transcripts
    for TYW1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TYW1 gene: 
    NM_018264.3  

    Unigene Cluster for TYW1:

    TRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
    Hs.520917  [show with all ESTs]
    Unigene Representative Sequence: NM_018264
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491969 ENST00000359626(uc003tvn.3 uc010lai.3) ENST00000442959
    ENST00000475392 ENST00000361660 ENST00000389196(uc011kef.2) ENST00000427620
    ENST00000445198 ENST00000495971 ENST00000468566 ENST00000498100

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TYW1
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TYW1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TYW1:
    hsa-miR-549 hsa-miR-148b* hsa-miR-2355-3p hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmid: TYW1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TYW1 (see all 7)
    OriGene shRNA RFP: TYW1
    OriGene siRNA: TYW1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TYW1
    Clone
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TYW1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TYW1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TYW1

    Additional cDNA sequence: 

    AK001762.1 AK022917.1 AK301330.1 BC015591.2 BC042156.1 BC051888.1 

    11 DOTS entries:

    DT.99933881  DT.100789029  DT.316409  DT.100774174  DT.423111  DT.105466  DT.92435437  DT.95370849 
    DT.100776166  DT.100789030  DT.95256568 

    24/167 AceView cDNA sequences (see all 167):

    BF434912 CB306182 BM989121 AI745344 AA114967 AI073929 AI913520 AI380108 
    AI922049 AA115497 CA454298 BM795100 BQ221024 AI277061 AI304874 AI744529 
    BC015591 AA115025 AA953059 AI273336 AA115040 BM768300 BU628109 BX112421 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TYW1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                          -               


    ECgene alternative splicing isoforms for TYW1

    Expression
    for TYW1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TYW1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TYW1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TYW1

    SOURCE GeneReport for Unigene cluster: Hs.520917
        SABiosciences Custom PCR Arrays for TYW1
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    In Situ
    Assay Products:     
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    Orthologs
    for TYW1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TYW1 gene from 7/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tyw11 , 5 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) less1, 5 80.52(n)1
    81.87(a)1    		   5 (69.00 cM)5
    1009291  NM_001015876.21  NP_001015876.11 
     1302556195 
    chicken
    (Gallus gallus)    		 Aves TYW11 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) less 76.65(n)
    83.79(a)    		   417478  XM_003642390.1  XP_003642438.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia CA788486.12   -- 78.51(n)    CA788486.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tyw11 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) less 68.5(n)
    71.23(a)    		   562076  NM_001077156.1  NP_001070624.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes TYW1(YPL207W)4
    TYW11    		 Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions less4
    Tyw1p1    		 50.92(n)1
    47.39(a)1    		   16(159909-162341)4
    8558941, 4  NP_015117.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G752001 tRNA wybutosine-synthesizing protein 1-like protein less 56.38(n)
    54.2(a)    		   843857  NM_106176.5  NP_177656.2 
    rice
    (Oryza sativa)    		 Liliopsida Os.334612 Oryza sativa (japonica cultivar-group) cDNA cloneJ023099L20, full insert sequence less 76.77(n)    AK100507.1 


    ENSEMBL Gene Tree for TYW1 (if available)
    TreeFam Gene Tree for TYW1 (if available) 

    Paralogs
    for TYW1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TYW1 gene
    1 SIMAP similar gene for TYW1 using alignment to 5 protein entries:     TYW1_HUMAN (see all proteins):
    TYW1B

    TYW1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TYW1
    PGOHUM00000250454 PGOHUM00000250873


    Genomic Variants
    for TYW1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5269 NCBI SNPs in TYW1 are shown (see all 5269)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs715631741,2
    		C,F--62796984(+) TATTCC/ATTCAC 1 -- int12Minor allele frequency- A:0.50NA 4
    rs715631751,2
    		C--62801403(+) GAGCCG/ACTGTG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs47184391,2
    		C,F,A,H,--66462667(+) CTGGAG/ATGCGG 1 -- int18Minor allele frequency- A:0.01NS EA NA WA 412
    rs47184401,2
    		C,F,A,H,--66462679(+) GGCGCA/GATCTT 1 -- int14Minor allele frequency- G:0.38NA WA 8
    rs1466709951,2
    		--66462776(+) ACGCCC/TGGCTA 1 -- int10--------
    rs117701141,2
    		C,H,--66462788(+) tttttA/Gtattt 1 -- int10--------
    rs1862745091,2
    		--66462881(+) AAAGTA/GCTGGA 1 -- int10--------
    rs1925101511,2
    		--66462913(+) GCCCGG/TCCAAC 1 -- int10--------
    rs1147975151,2
    		F,--66462994(+) TTGGGA/GTGGAT 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1383949931,2
    		F--66463068(+) GATACA/GTGGGA 2 T syn11Minor allele frequency- G:0.00NA 4542

    HapMap Linkage Disequilibrium report for TYW1 (66460160 - 66704501 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for TYW1
         9 CNVs: 69941 3683 94570 36700 38111 64851 81994 7640 44317
         4 Indels: 81996 81995 94571 94572

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    Disorders / Diseases
    for TYW1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TYW1 for disorders           About GeneDecksing

    OMIM gene information: 611243    OMIM disorders: --

    4 diseases for TYW1:    About MalaCards
    noma    fanconi's anemia    anemia    malaria

    Human Genome Epidemiology (HuGE) Navigator: TYW1 (1 document)

    Export disorders for TYW1 gene to outside databases

    Publications
    for TYW1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TYW1 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TYW1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. (PubMed id 17150819)1, 3 Noma A. and Suzuki T. (2006)
    2. Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. (PubMed id 16162496)1, 3 Waas W.F....Schimmel P. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)

    External Searches for TYW1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing TYW1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55253 HGNC: 25598 AceView: FLJ10900 Ensembl:ENSG00000198874 euGenes: HUgn55253
    ECgene: TYW1 H-InvDB: TYW1

    Other Databases showing TYW1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TYW1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TYW1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TYW1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TYW1 gene:
    Search GeneIP for patents involving TYW1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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