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Aliases for TYSND1 Gene

Aliases for TYSND1 Gene

  • Trypsin Domain Containing 1 2 3
  • Trypsin Domain-Containing Protein 1 3 4
  • Peroxisomal Cysteine Endopeptidase 2 3
  • Peroxisomal Leader Peptide-Processing Protease 3
  • EC 3.4.21.- 4
  • NET41 3

External Ids for TYSND1 Gene

Previous GeneCards Identifiers for TYSND1 Gene

  • GC10M071244
  • GC10M071567
  • GC10M071897
  • GC10M065890

Summaries for TYSND1 Gene

Entrez Gene Summary for TYSND1 Gene

  • This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for TYSND1 Gene

TYSND1 (Trypsin Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and protease binding.

UniProtKB/Swiss-Prot for TYSND1 Gene

  • Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYSND1 Gene

Genomics for TYSND1 Gene

Regulatory Elements for TYSND1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TYSND1 Gene

Start:
70,137,981 bp from pter
End:
70,146,740 bp from pter
Size:
8,760 bases
Orientation:
Minus strand

Genomic View for TYSND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TYSND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYSND1 Gene

Proteins for TYSND1 Gene

  • Protein details for TYSND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2T9J0-TYSD1_HUMAN
    Recommended name:
    Peroxisomal leader peptide-processing protease
    Protein Accession:
    Q2T9J0
    Secondary Accessions:
    • Q5SQT4
    • Q5SQU1
    • Q8N6H2
    • Q96AR5

    Protein attributes for TYSND1 Gene

    Size:
    566 amino acids
    Molecular mass:
    59309 Da
    Quaternary structure:
    • Homodimer. Forms a heterodimer with the C-terminal cleavage product (45 kDa form). Forms a heterodimer with the N-terminal cleavage product (15 kDa form). Interacts with PEX5. Interacts with LONP2.

    Alternative splice isoforms for TYSND1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TYSND1 Gene

Proteomics data for TYSND1 Gene at MOPED

Post-translational modifications for TYSND1 Gene

  • Self-cleavage gives rise to an N-terminal 15-kDa fragment and C-terminal 45-kDa fragment upon import into the peroxisomes. The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity
  • Ubiquitination at Lys389
  • Modification sites at PhosphoSitePlus

Other Protein References for TYSND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TYSND1 Gene

Domains for TYSND1 Gene

Protein Domains for TYSND1 Gene

Suggested Antigen Peptide Sequences for TYSND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2T9J0

UniProtKB/Swiss-Prot:

TYSD1_HUMAN :
  • Q2T9J0
Family:
  • Belongs to the peptidase S1B family.
genes like me logo Genes that share domains with TYSND1: view

No data available for Gene Families for TYSND1 Gene

Function for TYSND1 Gene

Molecular function for TYSND1 Gene

UniProtKB/Swiss-Prot Function: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.

Enzyme Numbers (IUBMB) for TYSND1 Gene

Gene Ontology (GO) - Molecular Function for TYSND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 22002062
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IMP 22002062
GO:0042802 identical protein binding IPI 22002062
genes like me logo Genes that share ontologies with TYSND1: view

Phenotypes for TYSND1 Gene

GenomeRNAi human phenotypes for TYSND1:
genes like me logo Genes that share phenotypes with TYSND1: view

Animal Model Products

CRISPR Products

miRNA for TYSND1 Gene

miRTarBase miRNAs that target TYSND1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TYSND1 Gene

Localization for TYSND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TYSND1 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TYSND1 Gene COMPARTMENTS Subcellular localization image for TYSND1 gene
Compartment Confidence
peroxisome 5
cytosol 2
mitochondrion 2
plasma membrane 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TYSND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA 22002062
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with TYSND1: view

Pathways for TYSND1 Gene

SuperPathways for TYSND1 Gene

No Data Available

Interacting Proteins for TYSND1 Gene

Gene Ontology (GO) - Biological Process for TYSND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IMP 22002062
GO:0016485 protein processing IMP 22002062
GO:0031998 regulation of fatty acid beta-oxidation IMP 22002062
GO:0051260 protein homooligomerization IDA 22002062
genes like me logo Genes that share ontologies with TYSND1: view

No data available for Pathways by source for TYSND1 Gene

Transcripts for TYSND1 Gene

Unigene Clusters for TYSND1 Gene

Trypsin domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TYSND1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TYSND1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TYSND1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6:
SP7:
SP8: - - - - - - -
SP9: - - - - -

Relevant External Links for TYSND1 Gene

GeneLoc Exon Structure for
TYSND1
ECgene alternative splicing isoforms for
TYSND1

Expression for TYSND1 Gene

mRNA expression in normal human tissues for TYSND1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TYSND1 Gene

SOURCE GeneReport for Unigene cluster for TYSND1 Gene Hs.533655

genes like me logo Genes that share expressions with TYSND1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TYSND1 Gene

Orthologs for TYSND1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TYSND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TYSND1 35
  • 98.65 (n)
  • 98.06 (a)
TYSND1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TYSND1 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TYSND1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tysnd1 35
  • 80.59 (n)
  • 80 (a)
Tysnd1 16
Tysnd1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TYSND1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tysnd1 35
  • 80.18 (n)
  • 80.53 (a)
chicken
(Gallus gallus)
Aves TYSND1 35
  • 60.28 (n)
  • 49.47 (a)
TYSND1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TYSND1 36
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4078 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17393 35
tysnd1 35
  • 50.44 (n)
  • 47.16 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5807 35
zebrafish
(Danio rerio)
Actinopterygii tysnd1 35
  • 47.63 (n)
  • 43.08 (a)
tysnd1 36
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3589 36
  • 26 (a)
OneToOne
Species with no ortholog for TYSND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TYSND1 Gene

ENSEMBL:
Gene Tree for TYSND1 (if available)
TreeFam:
Gene Tree for TYSND1 (if available)

Paralogs for TYSND1 Gene

No data available for Paralogs for TYSND1 Gene

Variants for TYSND1 Gene

Sequence variations from dbSNP and Humsavar for TYSND1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1053105 -- 70,138,242(-) TCACA(A/G)TGGGT utr-variant-3-prime, nc-transcript-variant
rs2292722 -- 70,142,657(+) CCAAA(C/G)AGCTG intron-variant
rs2394647 -- 70,138,599(+) GGGGG(A/C/G/T)TGCCC utr-variant-3-prime, nc-transcript-variant
rs2394648 -- 70,144,550(+) CTCCC(A/G)GGGAG intron-variant, nc-transcript-variant
rs3750774 -- 70,145,813(+) CCGGG(A/C)AGGCA reference, synonymous-codon, intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TYSND1 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407
nsv7054 CNV Insertion 18451855

Relevant External Links for TYSND1 Gene

HapMap Linkage Disequilibrium report
TYSND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYSND1 Gene

Disorders for TYSND1 Gene

(1) University of Copenhagen DISEASES for TYSND1 Gene

Relevant External Links for TYSND1

Genetic Association Database (GAD)
TYSND1
Human Genome Epidemiology (HuGE) Navigator
TYSND1
genes like me logo Genes that share disorders with TYSND1: view

No data available for UniProtKB/Swiss-Prot for TYSND1 Gene

Publications for TYSND1 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  2. Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids. (PMID: 17255948) Kurochkin I.V. … Okazaki Y. (EMBO J. 2007) 2 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid beta-oxidation in peroxisomal matrix. (PMID: 22002062) Okumoto K. … Fujiki Y. (J. Biol. Chem. 2011) 3 4
  5. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3

Products for TYSND1 Gene

Sources for TYSND1 Gene

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