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TYSND1 Gene

protein-coding   GIFtS: 53
GCID: GC10M071897

Trypsin Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Trypsin Domain Containing 11 2
Trypsin Domain-Containing Protein 12 3
NET412
Peroxisomal Leader Peptide-Processing Protease2
EC 3.4.21.-3

External Ids:    HGNC: 285311   Entrez Gene: 2197432   Ensembl: ENSG000001565217   OMIM: 6110175   UniProtKB: Q2T9J03   
ORGUL members:         

Export aliases for TYSND1 gene to outside databases

Previous GC identifers: GC10M071244 GC10M071567 GC10M065890


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TYSND1 Gene:
This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins
produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also
capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix.
The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative
splicing results in multiple transcript variants for this gene. (provided by RefSeq, Jan 2013)

GeneCards Summary for TYSND1 Gene:
TYSND1 (trypsin domain containing 1) is a protein-coding gene. Diseases associated with TYSND1 include zellweger syndrome, and retinitis. GO annotations related to this gene include protease binding and identical protein binding.

UniProtKB/Swiss-Prot: TYSD1_HUMAN, Q2T9J0
Function: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a
PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins
involved in the peroxisomal beta-oxidation of fatty acids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the TYSND1 gene promoter:
         AhR   AML1a   Pax-5   AP-1   Arnt   FOXL1   CREB   GATA-6   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTYSND1 promoter sequence
   Search Chromatin IP Primers for TYSND1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TYSND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

TYSND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TYSND1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M071897:  view genomic region     (about GC identifiers)

Start:
71,897,733 bp from pter      End:
71,906,496 bp from pter
Size:
8,764 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TYSD1_HUMAN, Q2T9J0 (See protein sequence)
Recommended Name: Peroxisomal leader peptide-processing protease  
Size: 566 amino acids; 59309 Da
Subunit: Homodimer. Forms a heterodimer with the C-terminal cleavage product (45 kDa form). Forms a heterodimer
with the N-terminal cleavage product (15 kDa form). Interacts with PEX5. Interacts with LONP2
Secondary accessions: Q5SQT4 Q5SQU1 Q8N6H2 Q96AR5
Alternative splicing: 2 isoforms:  Q2T9J0-1   Q2T9J0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TYSND1: NX_Q2T9J0

Explore proteomics data for TYSND1 at MOPED

Post-translational modifications: 

  • Self-cleavage gives rise to an N-terminal 15-kDa fragment and C-terminal 45-kDa fragment upon import into the
    peroxisomes. The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in
    self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity1
  • Ubiquitination2 at Lys389
  • Modification sites at PhosphoSitePlus

  • See TYSND1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035363.1  NP_775826.2  

    ENSEMBL proteins: 
     ENSP00000287078   ENSP00000335673  

    TYSND1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017345 Pept_S1A_Tysnd1
     IPR001254 Peptidase_S1
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q2T9J0

    ProtoNet protein and cluster: Q2T9J0

    UniProtKB/Swiss-Prot: TYSD1_HUMAN, Q2T9J0
    Similarity: Belongs to the peptidase S1B family


    TYSND1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYSD1_HUMAN, Q2T9J0
    Function: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a
    PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins
    involved in the peroxisomal beta-oxidation of fatty acids

         Enzyme Number (IUBMB): EC 3.4.21.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI--
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IMP--
    GO:0042802identical protein binding IPI--
         
    TYSND1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TYSND1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TYSND1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TYSND1
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    miRNA
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    miRTarBase miRNAs that target TYSND1:
    hsa-mir-155-5p (MIRT020801), hsa-mir-93-5p (MIRT048895)

    Block miRNA regulation of human, mouse, rat TYSND1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TYSND1 (see all 12):
    hsa-miR-3938 hsa-miR-125a-5p hsa-miR-875-3p hsa-miR-330-5p hsa-miR-627 hsa-miR-1291 hsa-miR-124 hsa-miR-670
    SwitchGear 3'UTR luciferase reporter plasmidTYSND1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TYSND1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): TYSND1 (NM_173555)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYSND1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TYSD1_HUMAN, Q2T9J0: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    cytosol2
    mitochondrion2
    plasma membrane2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777peroxisome IDA--

    TYSND1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TYSND1
    Interactions:

        Search GeneGlobe Interaction Network for TYSND1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for TYSND1 (Q2T9J03 ENSP000002870784) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG16L1Q676U53I2D: score=1 
    JOSD2Q8TAC23I2D: score=1 
    ACOX1ENSP000002932174STRING: ENSP00000293217
    CATENSP000002410524STRING: ENSP00000241052
    ECI2ENSP000003547374STRING: ENSP00000354737
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IMP--
    GO:0016485protein processing IMP--
    GO:0031998regulation of fatty acid beta-oxidation IMP--
    GO:0051260protein homooligomerization IDA--

    TYSND1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TYSND1 (TYSD1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TYSND1 gene (2 alternative transcripts): 
    NM_001040273.2  NM_173555.3  

    Unigene Cluster for TYSND1:

    Trypsin domain containing 1
    Hs.533655  [show with all ESTs]
    Unigene Representative Sequence: NM_173555
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494143 ENST00000287078(uc001jqr.3) ENST00000335494(uc001jqs.3)
    ENST00000479086(uc001jqq.3 uc001jqt.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TYSND1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TYSND1 (see all 12):
    hsa-miR-3938 hsa-miR-125a-5p hsa-miR-875-3p hsa-miR-330-5p hsa-miR-627 hsa-miR-1291 hsa-miR-124 hsa-miR-670
    SwitchGear 3'UTR luciferase reporter plasmidTYSND1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TYSND1
    Predesigned siRNA for gene silencing in human, mouse, rat TYSND1
    Clone
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    OriGene clones in human, mouse for TYSND1 (see all 13)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TYSND1 (NM_173555)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYSND1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TYSND1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TYSND1
      QuantiTect SYBR Green Assays in human, mouse, rat TYSND1
      QuantiFast Probe-based Assays in human, mouse, rat TYSND1

    Additional mRNA sequence: 

    AK074968.1 BC016840.1 BC030242.1 BC042629.1 BC047424.1 BC111501.1 NR_073580.1 NR_073581.1 
    NR_073582.1 NR_073591.1 NR_073592.1 NR_073593.1 NR_073594.1 NR_073595.1 

    16 DOTS entries:

    DT.95171726  DT.455072  DT.95171724  DT.100776127  DT.75110654  DT.95171723  DT.92422395  DT.121261108 
    DT.121261164  DT.121261040  DT.92001575  DT.100776128  DT.100776130  DT.121261117  DT.91740825  DT.75171099 

    Selected AceView cDNA sequences (see all 150):

    BM670951 AK097697 AI377960 BX340786 AA918067 BM664638 BM703137 BI766480 
    AA860182 CD671353 AL713282 AW188353 AI382207 BM553590 BM975929 AI563945 
    AA953270 BI829894 AI024441 BX282686 BC016840 CA442516 BM693889 BU183732 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TYSND1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
    SP1:                    -     -     -     -           -                                                   
    SP2:                    -     -     -     -                                                               
    SP3:                          -     -     -                 -                                             
    SP4:                          -     -     -                                                               
    SP5:                                -     -                                                               


    ECgene alternative splicing isoforms for TYSND1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TYSND1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTATTGAA
    TYSND1 Expression
    About this image

    TYSND1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TYSND1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533655
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYSND1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TYSND1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tysnd11 , 5 trypsin domain containing 11, 5 80.59(n)1
    80(a)1
      10 (32.26 cM)5
    717671  NM_027912.11  NP_082188.11 
     616955145 
    chicken
    (Gallus gallus)
    Aves TYSND11 trypsin domain containing 1 60.28(n)
    49.47(a)
      769373  XM_001232632.3  XP_001232633.2 
    lizard
    (Anolis carolinensis)
    Reptilia TYSND16
    trypsin domain containing 1
    46(a)
    1 ↔ 1
    3(51302552-51316471)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.40782 Xenopus laevis transcribed sequences 71.43(n)    48045536 
    zebrafish
    (Danio rerio)
    Actinopterygii tysnd11 trypsin domain containing 1 47.63(n)
    43.08(a)
      561667  NM_001128710.1  NP_001122182.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG35896
    --
    26(a)
    1 ↔ 1
    2R(20671095-20673065)


    ENSEMBL Gene Tree for TYSND1 (if available)
    TreeFam Gene Tree for TYSND1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TYSND1 (see all 277)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145244881,2
    F--71897285(+) ATTAAC/TTTACT 10 -- ds50011Minor allele frequency- T:0.03WA 118
    rs109991551,2
    C,F--71897293(+) ACTGTA/TGAACT 10 -- ds500113Minor allele frequency- N:0.00EA NA CSA WA 576
    rs1930667161,2
    --71897353(+) AGGAAC/TAACCA 10 -- ds50010--------
    rs1854386701,2
    --71897365(+) CCCAGG/TAGTGT 10 -- ds50010--------
    rs354890981,2
    C,F--71897385(+) GCCCCG/ATGTTT 10 -- ds50014Minor allele frequency- A:0.03NA WA 242
    rs1883566051,2
    --71897514(+) TCAGCC/TGGGTG 10 -- ds50010--------
    rs42930191,2
    C,F,A--71897517(+) GCCGGG/TTGTCC 10 -- ds50017Minor allele frequency- T:0.38WA NA CSA EA 366
    rs1157599691,2
    C,F--71897748(+) TTACCG/AGTTTA 10 -- ut31 nc-transcript-variant3Minor allele frequency- A:0.05WA NA EA 358
    rs761477161,2
    C,F--71897823(+) GGAAGG/CAGTGC 10 -- ut31 nc-transcript-variant3Minor allele frequency- C:0.08WA NA EA 358
    rs1917910401,2
    --71897871(+) GGAAGC/TGCCAG 10 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for TYSND1 (71897733 - 71906496 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TYSND1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7054CNV Insertion18451855
    esv32737CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TYSND1
    DNA2.0 Custom Variant and Variant Library Synthesis for TYSND1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611017    OMIM disorders: --

    3 diseases for TYSND1:    
    About MalaCards
    zellweger syndrome    retinitis    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for TYSND1:
    Zellweger syndrome

    TYSND1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TYSND1
    Human Genome Epidemiology (HuGE) Navigator: TYSND1 (2 documents)

    Export disorders for TYSND1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TYSND1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TYSND1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid beta-oxidation in peroxisomal matrix. (PubMed id 22002062)1, 2 Okumoto K.... Fujiki Y. (J. Biol. Chem. 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids. (PubMed id 17255948)1, 3 Kurochkin I.V....Okazaki Y. (EMBO J. 2007)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    6. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Sequence-based discovery of the human and rodent peroxisomal proteome. (PubMed id 16128611)1 Kurochkin I.V....SchAPnbach C. (Appl. Bioinformatics 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219743 HGNC: 28531 AceView: TYSND1 Ensembl:ENSG00000156521 euGenes: HUgn219743
    ECgene: TYSND1 H-InvDB: TYSND1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TYSND1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TYSND1 gene:
    Search GeneIP for patents involving TYSND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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