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Aliases for TYRO3 Gene

Aliases for TYRO3 Gene

  • TYRO3 Protein Tyrosine Kinase 2 3 5
  • Tyrosine-Protein Kinase DTK 3 4
  • Tyrosine-Protein Kinase RSE 3 4
  • Tyrosine-Protein Kinase SKY 3 4
  • Tyrosine-Protein Kinase TIF 3 4
  • EC 2.7.10.1 4 63
  • Dtk 3 4
  • Sky 3 4
  • Tif 3 4
  • RSE 3 4
  • BYK 3 4
  • Tyrosine-Protein Kinase Byk 3
  • Tyrosine-Protein Kinase BYK 4
  • EC 2.7.10 63
  • Etk-2 3
  • Rek 3

External Ids for TYRO3 Gene

Previous HGNC Symbols for TYRO3 Gene

  • RSE

Previous GeneCards Identifiers for TYRO3 Gene

  • GC15P037219
  • GC15P034747
  • GC15P039430
  • GC15P039567
  • GC15P039638
  • GC15P041851
  • GC15P018699

Summaries for TYRO3 Gene

Entrez Gene Summary for TYRO3 Gene

  • The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

GeneCards Summary for TYRO3 Gene

TYRO3 (TYRO3 Protein Tyrosine Kinase) is a Protein Coding gene. Diseases associated with TYRO3 include External Ear Carcinoma and Lymphocytic Choriomeningitis. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RYK.

UniProtKB/Swiss-Prot for TYRO3 Gene

  • Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

  • (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:25277499, PubMed:22156524, PubMed:22673088). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:17005688).

Gene Wiki entry for TYRO3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYRO3 Gene

Genomics for TYRO3 Gene

Regulatory Elements for TYRO3 Gene

Enhancers for TYRO3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TYRO3 on UCSC Golden Path with GeneCards custom track

Promoters for TYRO3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TYRO3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TYRO3 gene promoter:

Genomic Location for TYRO3 Gene

Chromosome:
15
Start:
41,557,675 bp from pter
End:
41,583,586 bp from pter
Size:
25,912 bases
Orientation:
Plus strand

Genomic View for TYRO3 Gene

Genes around TYRO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYRO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYRO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYRO3 Gene

Proteins for TYRO3 Gene

  • Protein details for TYRO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06418-TYRO3_HUMAN
    Recommended name:
    Tyrosine-protein kinase receptor TYRO3
    Protein Accession:
    Q06418
    Secondary Accessions:
    • O14953
    • Q86VR3

    Protein attributes for TYRO3 Gene

    Size:
    890 amino acids
    Molecular mass:
    96905 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 (By similarity). Interacts with PIK3R1; this interaction increases PI3-kinase activity (By similarity).
    SequenceCaution:
    • Sequence=BAA21781.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TYRO3 Gene

neXtProt entry for TYRO3 Gene

Proteomics data for TYRO3 Gene at MOPED

Post-translational modifications for TYRO3 Gene

  • Autophosphorylated.
  • Ubiquitination at Lys 582
  • Glycosylation at Asn 63, Asn 191, Asn 230, Asn 240, Asn 293, Asn 366, and Asn 380
  • Modification sites at PhosphoSitePlus

Other Protein References for TYRO3 Gene

Domains & Families for TYRO3 Gene

Suggested Antigen Peptide Sequences for TYRO3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q06418

UniProtKB/Swiss-Prot:

TYRO3_HUMAN :
  • Contains 2 fibronectin type-III domains.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Domain:
  • Contains 2 fibronectin type-III domains.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
genes like me logo Genes that share domains with TYRO3: view

Function for TYRO3 Gene

Molecular function for TYRO3 Gene

GENATLAS Biochemistry:
Rse tyrosine kinase 3,mainly expressed in brain,involved in the protection of neurons from apoptosis,across neuronal migration,expressed in neural lymphoid,vascular and reproductive tissue,involved in the regulation of spermatogenesis and in primary and tumor cell lines derived from these sources,receptor for and activated by GAS6 and PROS1
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:25277499, PubMed:22156524, PubMed:22673088). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:17005688).

Enzyme Numbers (IUBMB) for TYRO3 Gene

Gene Ontology (GO) - Molecular Function for TYRO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA,IDA 7537495
GO:0004716 receptor signaling protein tyrosine kinase activity NAS 7511603
genes like me logo Genes that share ontologies with TYRO3: view
genes like me logo Genes that share phenotypes with TYRO3: view

Animal Models for TYRO3 Gene

MGI Knock Outs for TYRO3:

Animal Model Products

  • Taconic Biosciences Mouse Models for TYRO3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TYRO3 Gene

Localization for TYRO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TYRO3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TYRO3 Gene COMPARTMENTS Subcellular localization image for TYRO3 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
plasma membrane 5
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TYRO3 Gene

Pathways & Interactions for TYRO3 Gene

genes like me logo Genes that share pathways with TYRO3: view

SIGNOR curated interactions for TYRO3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TYRO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001779 natural killer cell differentiation IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007155 cell adhesion NAS 8108112
GO:0007165 signal transduction NAS 7511603
GO:0014065 phosphatidylinositol 3-kinase signaling NAS 10627473
genes like me logo Genes that share ontologies with TYRO3: view

Drugs & Compounds for TYRO3 Gene

(5) Drugs for TYRO3 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
growth arrest specific protein 6 Pharma 0
protein S Pharma 18
BMS-777607 Pharma C-Met inhibitor, potent and selective, Kinase Inhibitors 0

(1) Additional Compounds for TYRO3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for TYRO3 Gene

Compound Action Cas Number
BMS-777607 C-Met inhibitor, potent and selective 1025720-94-8
genes like me logo Genes that share compounds with TYRO3: view

Transcripts for TYRO3 Gene

Unigene Clusters for TYRO3 Gene

TYRO3 protein tyrosine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TYRO3 Gene

No ASD Table

Relevant External Links for TYRO3 Gene

GeneLoc Exon Structure for
TYRO3
ECgene alternative splicing isoforms for
TYRO3

Expression for TYRO3 Gene

mRNA expression in normal human tissues for TYRO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TYRO3 Gene

This gene is overexpressed in Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for TYRO3 Gene

This gene is overexpressed in Spinal cord (63.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TYRO3 Gene



SOURCE GeneReport for Unigene cluster for TYRO3 Gene Hs.381282

mRNA Expression by UniProt/SwissProt for TYRO3 Gene

Q06418-TYRO3_HUMAN
Tissue specificity: Abundant in the brain and lower levels in other tissues.
genes like me logo Genes that share expression patterns with TYRO3: view

Protein tissue co-expression partners for TYRO3 Gene

Primer Products

Orthologs for TYRO3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TYRO3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TYRO3 35
  • 90.29 (n)
  • 91.79 (a)
TYRO3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TYRO3 35
  • 91.83 (n)
  • 94.46 (a)
TYRO3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tyro3 35
  • 87.45 (n)
  • 89.71 (a)
Tyro3 16
Tyro3 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TYRO3 35
  • 99.42 (n)
  • 99.5 (a)
TYRO3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tyro3 35
  • 87.52 (n)
  • 89.71 (a)
oppossum
(Monodelphis domestica)
Mammalia TYRO3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TYRO3 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TYRO3 35
  • 69.71 (n)
  • 70.32 (a)
TYRO3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TYRO3 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tyro3 35
  • 63.51 (n)
  • 62.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xksy 35
zebrafish
(Danio rerio)
Actinopterygii dtk 35
tyro3 35
  • 56.77 (n)
  • 52.87 (a)
tyro3 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F11E6.8 37
  • 39 (a)
T14E8.1a 37
  • 38 (a)
T14E8.1b 37
  • 38 (a)
ZK593.9 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for TYRO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TYRO3 Gene

ENSEMBL:
Gene Tree for TYRO3 (if available)
TreeFam:
Gene Tree for TYRO3 (if available)

Paralogs for TYRO3 Gene

Paralogs for TYRO3 Gene

Pseudogenes.org Pseudogenes for TYRO3 Gene

genes like me logo Genes that share paralogs with TYRO3: view

Variants for TYRO3 Gene

Sequence variations from dbSNP and Humsavar for TYRO3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_041876 -
rs17854578 - 41,559,319(+) GCCAC(C/T)GCGGC intron-variant, upstream-variant-2KB, reference, missense
rs12148316 - 41,568,292(+) AGTGA(A/T)CCCCG reference, missense
rs17857363 - 41,571,082(+) AGGAT(A/G)GCTCC reference, missense
rs1042057 - 41,578,047(+) CACTG(C/T)GGGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TYRO3 Gene

Variant ID Type Subtype PubMed ID
esv2749609 CNV Deletion 23290073
esv2749610 CNV Deletion 23290073
esv2749611 CNV Deletion 23290073
esv2749612 CNV Deletion 23290073
esv2749613 CNV Deletion 23290073
esv2749614 CNV Deletion 23290073
esv2749615 CNV Deletion 23290073
esv2749616 CNV Deletion 23290073
esv2749617 CNV Deletion 23290073
esv2749618 CNV Deletion 23290073
esv2749620 CNV Deletion 23290073

Variation tolerance for TYRO3 Gene

Residual Variation Intolerance Score: 10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.27; 81.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TYRO3 Gene

Disorders for TYRO3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TYRO3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
external ear carcinoma
  • carcinoma of external ear
lymphocytic choriomeningitis
  • lcm
dentine erosion
la crosse encephalitis
  • california encephalitis
- elite association - COSMIC cancer census association via MalaCards
Search TYRO3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TYRO3

Genetic Association Database (GAD)
TYRO3
Human Genome Epidemiology (HuGE) Navigator
TYRO3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TYRO3
genes like me logo Genes that share disorders with TYRO3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TYRO3 Gene

Publications for TYRO3 Gene

  1. RSE, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. (PMID: 7511603) Mark M.R. … Godowski P.J. (J. Biol. Chem. 1994) 3 4 23 67
  2. A genomic screen identifies TYRO3 as a MITF regulator in melanoma. (PMID: 19805117) Zhu S. … Wu X. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. Tyro3 family-mediated cell entry of Ebola and Marburg viruses. (PMID: 17005688) Shimojima M. … Kawaoka Y. (J. Virol. 2006) 3 23
  4. Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. (PMID: 15733062) Gould W.R. … Perrin L.A. (J. Thromb. Haemost. 2005) 3 23
  5. The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases. (PMID: 15964779) Hafizi S. … DahlbAock B. (Int. J. Biochem. Cell Biol. 2005) 3 23

Products for TYRO3 Gene

Sources for TYRO3 Gene

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