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Aliases for TYRO3 Gene

Aliases for TYRO3 Gene

  • TYRO3 Protein Tyrosine Kinase 2 3
  • Tyrosine-Protein Kinase DTK 3 4
  • Tyrosine-Protein Kinase RSE 3 4
  • Tyrosine-Protein Kinase SKY 3 4
  • Tyrosine-Protein Kinase TIF 3 4
  • EC 2.7.10.1 4 64
  • Dtk 3 4
  • Sky 3 4
  • Tif 3 4
  • RSE 3 4
  • BYK 3 4
  • Tyrosine-Protein Kinase Receptor TYRO3 3
  • Tyrosine-Protein Kinase Byk 3
  • Tyrosine-Protein Kinase BYK 4
  • EC 2.7.10 64
  • Etk-2 3
  • Rek 3

External Ids for TYRO3 Gene

Previous Symbols for TYRO3 Gene

  • RSE

Summaries for TYRO3 Gene

Entrez Gene Summary for TYRO3 Gene

  • The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

GeneCards Summary for TYRO3 Gene

TYRO3 (TYRO3 Protein Tyrosine Kinase) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include protein heterodimerization activity and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is MET.

UniProtKB/Swiss-Prot for TYRO3 Gene

  • Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Gene Wiki entry for TYRO3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYRO3 Gene

Genomics for TYRO3 Gene

Genomic Location for TYRO3 Gene

Start:
41,557,675 bp from pter
End:
41,583,586 bp from pter
Size:
25,912 bases
Orientation:
Plus strand

Genomic View for TYRO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TYRO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYRO3 Gene

Regulatory Elements for TYRO3 Gene

Transcription factor binding sites by QIAGEN in the TYRO3 gene promoter:

Proteins for TYRO3 Gene

  • Protein details for TYRO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06418-TYRO3_HUMAN
    Recommended name:
    Tyrosine-protein kinase receptor TYRO3
    Protein Accession:
    Q06418
    Secondary Accessions:
    • O14953
    • Q86VR3

    Protein attributes for TYRO3 Gene

    Size:
    890 amino acids
    Molecular mass:
    96905 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 (By similarity). Interacts with PIK3R1; this interaction increases PI3-kinase activity (By similarity).
    SequenceCaution:
    • Sequence=BAA21781.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TYRO3 Gene

neXtProt entry for TYRO3 Gene

Proteomics data for TYRO3 Gene at MOPED

Post-translational modifications for TYRO3 Gene

Other Protein References for TYRO3 Gene

Domains for TYRO3 Gene

Gene Families for TYRO3 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
IUPHAR :

UniProtKB/Swiss-Prot:

TYRO3_HUMAN
Domain:
  • Contains 2 fibronectin type-III domains.:
    • Q06418
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q06418
  • Contains 1 protein kinase domain.:
    • Q06418
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.:
    • Q06418
genes like me logo Genes that share domains with TYRO3: view

Function for TYRO3 Gene

Molecular function for TYRO3 Gene

GENATLAS Biochemistry: Rse tyrosine kinase 3,mainly expressed in brain,involved in the protection of neurons from apoptosis,across neuronal migration,expressed in neural lymphoid,vascular and reproductive tissue,involved in the regulation of spermatogenesis and in primary and tumor cell lines derived from these sources,receptor for and activated by GAS6 and PROS1
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Enzyme Numbers (IUBMB) for TYRO3 Gene

Gene Ontology (GO) - Molecular Function for TYRO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity IDA 7537495
GO:0004714 transmembrane receptor protein tyrosine kinase activity NAS 7511603
GO:0004716 receptor signaling protein tyrosine kinase activity NAS 7511603
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TYRO3: view
genes like me logo Genes that share phenotypes with TYRO3: view

Animal Models for TYRO3 Gene

MGI Knock Outs for TYRO3:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for TYRO3 Gene

Localization for TYRO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TYRO3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TYRO3 Gene COMPARTMENTS Subcellular localization image for TYRO3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
nucleus 4
cytoskeleton 2
extracellular 2
cytosol 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TYRO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005635 nuclear envelope ISS --
GO:0005789 endoplasmic reticulum membrane ISS --
GO:0005887 integral component of plasma membrane NAS 7511603
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TYRO3: view

Pathways for TYRO3 Gene

genes like me logo Genes that share pathways with TYRO3: view

Pathways by source for TYRO3 Gene

1 Cell Signaling Technology pathway for TYRO3 Gene

Gene Ontology (GO) - Biological Process for TYRO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001779 natural killer cell differentiation IEA --
GO:0006468 protein phosphorylation --
GO:0007155 cell adhesion NAS 8108112
GO:0007165 signal transduction NAS 7511603
GO:0007283 spermatogenesis ISS --
genes like me logo Genes that share ontologies with TYRO3: view

Compounds for TYRO3 Gene

(2) HMDB Compounds for TYRO3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) IUPHAR Ligand for TYRO3 Gene

Ligand Type Action Affinity Pubmed IDs
protein S None None
growth arrest specific protein 6 None None

(1) Novoseek inferred chemical compound relationships for TYRO3 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 69.8 41
genes like me logo Genes that share compounds with TYRO3: view

Transcripts for TYRO3 Gene

Unigene Clusters for TYRO3 Gene

TYRO3 protein tyrosine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TYRO3 Gene

No ASD Table

Relevant External Links for TYRO3 Gene

GeneLoc Exon Structure for
TYRO3
ECgene alternative splicing isoforms for
TYRO3

Expression for TYRO3 Gene

mRNA expression in normal human tissues for TYRO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TYRO3 Gene

This gene is overexpressed in Brain - Cortex (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TYRO3 Gene

SOURCE GeneReport for Unigene cluster for TYRO3 Gene Hs.381282

mRNA Expression by UniProt/SwissProt for TYRO3 Gene

Q06418-TYRO3_HUMAN
Tissue specificity: Abundant in the brain and lower levels in other tissues
genes like me logo Genes that share expressions with TYRO3: view

Orthologs for TYRO3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TYRO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TYRO3 36
  • 99.42 (n)
  • 99.5 (a)
TYRO3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TYRO3 36
  • 90.29 (n)
  • 91.79 (a)
TYRO3 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TYRO3 36
  • 91.83 (n)
  • 94.46 (a)
TYRO3 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tyro3 36
  • 87.45 (n)
  • 89.71 (a)
Tyro3 16
Tyro3 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TYRO3 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TYRO3 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tyro3 36
  • 87.52 (n)
  • 89.71 (a)
chicken
(Gallus gallus)
Aves TYRO3 36
  • 69.71 (n)
  • 70.32 (a)
TYRO3 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TYRO3 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xksy 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tyro3 36
  • 63.51 (n)
  • 62.19 (a)
zebrafish
(Danio rerio)
Actinopterygii dtk 36
tyro3 36
  • 56.77 (n)
  • 52.87 (a)
tyro3 37
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK593.9 38
  • 32 (a)
F11E6.8 38
  • 39 (a)
T14E8.1a 38
  • 38 (a)
T14E8.1b 38
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
Species with no ortholog for TYRO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TYRO3 Gene

ENSEMBL:
Gene Tree for TYRO3 (if available)
TreeFam:
Gene Tree for TYRO3 (if available)

Paralogs for TYRO3 Gene

Paralogs for TYRO3 Gene

Pseudogenes.org Pseudogenes for TYRO3 Gene

genes like me logo Genes that share paralogs with TYRO3: view

Variants for TYRO3 Gene

Sequence variations from dbSNP and Humsavar for TYRO3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2681 -- 41,574,223(+) GAGAC(A/C)CCAGC intron-variant
rs12259 -- 41,579,294(+) CTGTT(A/G)GTTGC utr-variant-3-prime
rs735149 -- 41,562,181(+) GGGGG(A/C)AGCAT intron-variant
rs1023193 -- 41,563,538(-) CTCCA(A/C)CTCAG intron-variant
rs1023194 -- 41,563,531(-) TCAGC(A/G)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TYRO3 Gene

Variant ID Type Subtype PubMed ID
esv2749609 CNV Deletion 23290073
esv2749610 CNV Deletion 23290073
esv2749611 CNV Deletion 23290073
esv2749612 CNV Deletion 23290073
esv2749613 CNV Deletion 23290073
esv2749614 CNV Deletion 23290073
esv2749615 CNV Deletion 23290073
esv2749616 CNV Deletion 23290073
esv2749617 CNV Deletion 23290073
esv2749618 CNV Deletion 23290073
esv2749620 CNV Deletion 23290073

Relevant External Links for TYRO3 Gene

HapMap Linkage Disequilibrium report
TYRO3

Disorders for TYRO3 Gene

(1) University of Copenhagen DISEASES for TYRO3 Gene

(1) Novoseek inferred disease relationships for TYRO3 Gene

Disease -log(P) Hits PubMed IDs
thrombosis 23.1 2

Relevant External Links for TYRO3

Genetic Association Database (GAD)
TYRO3
Human Genome Epidemiology (HuGE) Navigator
TYRO3
genes like me logo Genes that share disorders with TYRO3: view

No data available for UniProtKB/Swiss-Prot for TYRO3 Gene

Publications for TYRO3 Gene

  1. RSE, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. (PMID: 7511603) Mark M.R. … Godowski P.J. (J. Biol. Chem. 1994) 3 4 23
  2. Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase. (PMID: 7537495) Toshima J. … Mizuno K. (Biochem. Biophys. Res. Commun. 1995) 3 4 23
  3. Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain. (PMID: 8108112) Ohashi K. … Nakamura T. (Oncogene 1994) 3 4 23
  4. Tyro3 family-mediated cell entry of Ebola and Marburg viruses. (PMID: 17005688) Shimojima M. … Kawaoka Y. (J. Virol. 2006) 3 4 23
  5. A genomic screen identifies TYRO3 as a MITF regulator in melanoma. (PMID: 19805117) Zhu S. … Wu X. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23

Products for TYRO3 Gene

  • Addgene plasmids for TYRO3

Sources for TYRO3 Gene

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