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Aliases for TYRO3 Gene

Aliases for TYRO3 Gene

  • TYRO3 Protein Tyrosine Kinase 2 3 5
  • Tyrosine-Protein Kinase DTK 3 4
  • Tyrosine-Protein Kinase RSE 3 4
  • Tyrosine-Protein Kinase SKY 3 4
  • Tyrosine-Protein Kinase TIF 3 4
  • EC 2.7.10.1 4 58
  • Dtk 3 4
  • Sky 3 4
  • Tif 3 4
  • RSE 3 4
  • BYK 3 4
  • Tyrosine-Protein Kinase Receptor TYRO3 3
  • Tyrosine-Protein Kinase Byk 3
  • Tyrosine-Protein Kinase BYK 4
  • EC 2.7.10 58
  • Etk-2 3
  • Rek 3

External Ids for TYRO3 Gene

Previous HGNC Symbols for TYRO3 Gene

  • RSE

Previous GeneCards Identifiers for TYRO3 Gene

  • GC15P037219
  • GC15P034747
  • GC15P039430
  • GC15P039567
  • GC15P039638
  • GC15P041851
  • GC15P018699

Summaries for TYRO3 Gene

Entrez Gene Summary for TYRO3 Gene

  • The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

GeneCards Summary for TYRO3 Gene

TYRO3 (TYRO3 Protein Tyrosine Kinase) is a Protein Coding gene. Diseases associated with TYRO3 include Lymphocytic Choriomeningitis and External Ear Carcinoma. Among its related pathways are Akt Signaling and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AXL.

UniProtKB/Swiss-Prot for TYRO3 Gene

  • Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

  • (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:25277499, PubMed:22156524, PubMed:22673088). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:17005688).

Gene Wiki entry for TYRO3 Gene

Additional gene information for TYRO3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYRO3 Gene

Genomics for TYRO3 Gene

Regulatory Elements for TYRO3 Gene

Enhancers for TYRO3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H041584 1.3 Ensembl ENCODE dbSUPER 18.1 +28.1 28148 2 CTCF PKNOX1 MAX DMAP1 RAD21 HIC1 POLR2A EZH2 GATAD2A RFX1 TYRO3 RPAP1 PLA2G4B GC15P041578 PIR47510
GH15H041786 1.4 Ensembl ENCODE dbSUPER 15 +233.6 233595 8 HDAC1 PKNOX1 TBL1XR1 TCF12 ZNF121 EGR1 FOS RUNX3 IKZF2 SMARCA5 JMJD7 TYRO3 SPTBN5 JMJD7-PLA2G4B ENSG00000250379 PLA2G4B LTK RPAP1 MAPKBP1 GC15P041819
GH15H041492 1.7 FANTOM5 ENCODE dbSUPER 11 -62.9 -62856 5 FOXA2 ZFP64 SIN3A ARID4B DMAP1 ZNF2 YY1 SLC30A9 ZNF766 SP3 NDUFAF1 MGA RPAP1 RTF1 RAD51-AS1 INO80 ENSG00000260814 DNAJC17 LOC105370795 GANC
GH15H041931 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +383.9 383919 19 PKNOX1 SIN3A GATA2 ZNF207 ATF7 FOS RUNX3 DEK MAFF GLIS1 EHD4 LTK PLA2G4E-AS1 SPTBN5 LOC105370792 MAPKBP1 PLA2G4E TYRO3 RPAP1 OIP5
GH15H041925 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +370.8 370764 6 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 BRCA1 YY1 ZNF143 FOS SPTBN5 EHD4 LOC105370792 PLA2G4E-AS1 ENSG00000250379 JMJD7 JMJD7-PLA2G4B MAPKBP1 PLA2G4E TYRO3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TYRO3 on UCSC Golden Path with GeneCards custom track

Promoters for TYRO3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075648 1625 1401 TBP CTCF MXI1 RB1 ZNF76 ZBTB40 FOSL1 CCNT2 E2F1 CTBP1

Transcription factor binding sites by QIAGEN in the TYRO3 gene promoter:

Genomic Location for TYRO3 Gene

Chromosome:
15
Start:
41,557,675 bp from pter
End:
41,583,586 bp from pter
Size:
25,912 bases
Orientation:
Plus strand

Genomic View for TYRO3 Gene

Genes around TYRO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYRO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYRO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYRO3 Gene

Proteins for TYRO3 Gene

  • Protein details for TYRO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06418-TYRO3_HUMAN
    Recommended name:
    Tyrosine-protein kinase receptor TYRO3
    Protein Accession:
    Q06418
    Secondary Accessions:
    • O14953
    • Q86VR3

    Protein attributes for TYRO3 Gene

    Size:
    890 amino acids
    Molecular mass:
    96905 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 (By similarity). Interacts with PIK3R1; this interaction increases PI3-kinase activity (By similarity).
    SequenceCaution:
    • Sequence=BAA21781.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TYRO3 Gene

neXtProt entry for TYRO3 Gene

Selected DME Specific Peptides for TYRO3 Gene

Q06418:
  • YSGDYYR
  • GNRLKQP
  • RDLAARN
  • VAVKMLK
  • DIEEFLREAACMKEFDHPHV
  • AVGPPEP
  • DMTVCVADFGLS
  • QQFTLGR
  • GDYYRQG
  • PAVHFRAARSFNRE
  • KGRLPIPMVILPFMKHGDLHAFLL
  • SRIGENPFNLPLQTL
  • FSCEAHN
  • GQTPYAG
  • ALALILLRKRRKETRFG
  • VSQGQPVKLNCS
  • TRGQTPY
  • SDVWAFGVT

Post-translational modifications for TYRO3 Gene

  • Autophosphorylated.
  • Ubiquitination at Lys582
  • Glycosylation at posLast=6363, posLast=191191, posLast=230230, posLast=240240, Asn293, Asn366, and Asn380
  • Modification sites at PhosphoSitePlus

Domains & Families for TYRO3 Gene

Gene Families for TYRO3 Gene

Suggested Antigen Peptide Sequences for TYRO3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q06418

UniProtKB/Swiss-Prot:

TYRO3_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
genes like me logo Genes that share domains with TYRO3: view

Function for TYRO3 Gene

Molecular function for TYRO3 Gene

GENATLAS Biochemistry:
Rse tyrosine kinase 3,mainly expressed in brain,involved in the protection of neurons from apoptosis,across neuronal migration,expressed in neural lymphoid,vascular and reproductive tissue,involved in the regulation of spermatogenesis and in primary and tumor cell lines derived from these sources,receptor for and activated by GAS6 and PROS1
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:25277499, PubMed:22156524, PubMed:22673088). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:17005688).

Enzyme Numbers (IUBMB) for TYRO3 Gene

Phenotypes From GWAS Catalog for TYRO3 Gene

Gene Ontology (GO) - Molecular Function for TYRO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IDA,IEA 7537495
GO:0004714 transmembrane receptor protein tyrosine kinase activity NAS 7511603
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity NAS 7511603
genes like me logo Genes that share ontologies with TYRO3: view
genes like me logo Genes that share phenotypes with TYRO3: view

Animal Models for TYRO3 Gene

MGI Knock Outs for TYRO3:

Animal Model Products

  • Taconic Biosciences Mouse Models for TYRO3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TYRO3
  • Applied Biological Materials Clones for TYRO3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TYRO3 Gene

Localization for TYRO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TYRO3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TYRO3 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endoplasmic reticulum 5
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TYRO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005635 nuclear envelope ISS --
GO:0005789 endoplasmic reticulum membrane ISS --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane NAS 7511603
genes like me logo Genes that share ontologies with TYRO3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TYRO3 Gene

Pathways & Interactions for TYRO3 Gene

genes like me logo Genes that share pathways with TYRO3: view

SIGNOR curated interactions for TYRO3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TYRO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001779 natural killer cell differentiation IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007155 cell adhesion NAS 8108112
GO:0007165 signal transduction NAS 7511603
GO:0007283 spermatogenesis ISS,IEA --
genes like me logo Genes that share ontologies with TYRO3: view

Drugs & Compounds for TYRO3 Gene

(6) Drugs for TYRO3 Gene - From: PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cabozantinib Approved Pharma Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
BMS-777607 Investigational Pharma C-Met inhibitor, potent and selective, Kinase Inhibitors 0
growth arrest specific protein 6 Pharma 0
protein S Pharma 21
ATP Nutra Agonist 0

(1) Additional Compounds for TYRO3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for TYRO3 Gene

Compound Action Cas Number
BMS-777607 C-Met inhibitor, potent and selective 1025720-94-8
genes like me logo Genes that share compounds with TYRO3: view

Drug Products

Transcripts for TYRO3 Gene

Unigene Clusters for TYRO3 Gene

TYRO3 protein tyrosine kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TYRO3
  • Applied Biological Materials Clones for TYRO3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TYRO3 Gene

No ASD Table

Relevant External Links for TYRO3 Gene

GeneLoc Exon Structure for
TYRO3
ECgene alternative splicing isoforms for
TYRO3

Expression for TYRO3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TYRO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TYRO3 Gene

This gene is overexpressed in Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for TYRO3 Gene

This gene is overexpressed in Spinal cord (63.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TYRO3 Gene



Protein tissue co-expression partners for TYRO3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TYRO3 Gene:

TYRO3

SOURCE GeneReport for Unigene cluster for TYRO3 Gene:

Hs.381282

mRNA Expression by UniProt/SwissProt for TYRO3 Gene:

Q06418-TYRO3_HUMAN
Tissue specificity: Abundant in the brain and lower levels in other tissues.

Evidence on tissue expression from TISSUES for TYRO3 Gene

  • Nervous system(4.8)
  • Skin(4.4)
genes like me logo Genes that share expression patterns with TYRO3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TYRO3 Gene

Orthologs for TYRO3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TYRO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TYRO3 33 34
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia TYRO3 33 34
  • 91.83 (n)
cow
(Bos Taurus)
Mammalia TYRO3 33 34
  • 90.29 (n)
rat
(Rattus norvegicus)
Mammalia Tyro3 33
  • 87.52 (n)
mouse
(Mus musculus)
Mammalia Tyro3 33 16 34
  • 87.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TYRO3 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TYRO3 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TYRO3 33 34
  • 69.71 (n)
lizard
(Anolis carolinensis)
Reptilia TYRO3 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tyro3 33
  • 63.51 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xksy 33
zebrafish
(Danio rerio)
Actinopterygii tyro3 33 34
  • 56.77 (n)
dtk 33
worm
(Caenorhabditis elegans)
Secernentea F11E6.8 35
  • 39 (a)
T14E8.1a 35
  • 38 (a)
T14E8.1b 35
  • 38 (a)
ZK593.9 35
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
Species where no ortholog for TYRO3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TYRO3 Gene

ENSEMBL:
Gene Tree for TYRO3 (if available)
TreeFam:
Gene Tree for TYRO3 (if available)

Paralogs for TYRO3 Gene

Paralogs for TYRO3 Gene

Pseudogenes.org Pseudogenes for TYRO3 Gene

genes like me logo Genes that share paralogs with TYRO3: view

Variants for TYRO3 Gene

Sequence variations from dbSNP and Humsavar for TYRO3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000074476 -- 41,579,265(+) GGGTC(C/T)TAGCT utr-variant-3-prime
rs1000438821 -- 41,563,453(+) GCTAG(C/G)TTCTC intron-variant
rs1000469918 -- 41,563,126(+) GCAGA(A/G)AGGGG intron-variant
rs1000495139 -- 41,560,984(+) TCCAC(A/T)CTGTC intron-variant
rs1000796718 -- 41,564,657(+) AGAGA(C/G)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TYRO3 Gene

Variant ID Type Subtype PubMed ID
dgv1194n106 CNV deletion 24896259
dgv1195n106 CNV deletion 24896259
dgv1196n106 CNV deletion 24896259
dgv1197n106 CNV deletion 24896259
dgv1198n106 CNV deletion 24896259
dgv1199n106 CNV deletion 24896259
dgv1200n106 CNV deletion 24896259
dgv1201n106 CNV deletion 24896259
dgv1202n106 CNV duplication 24896259
esv2749609 CNV deletion 23290073
esv2749610 CNV deletion 23290073
esv2749611 CNV deletion 23290073
esv2749612 CNV deletion 23290073
esv2749613 CNV deletion 23290073
esv2749614 CNV deletion 23290073
esv2749615 CNV deletion 23290073
esv2749616 CNV deletion 23290073
esv2749617 CNV deletion 23290073
esv2749618 CNV deletion 23290073
esv2749620 CNV deletion 23290073
esv3552368 CNV deletion 23714750
esv3636245 CNV loss 21293372
nsv1052902 CNV gain 25217958
nsv1069854 CNV deletion 25765185
nsv1069855 CNV deletion 25765185
nsv1070268 CNV deletion 25765185
nsv1070269 CNV deletion 25765185
nsv1070695 CNV deletion 25765185
nsv1071204 CNV deletion 25765185
nsv1071206 CNV deletion 25765185
nsv1071207 CNV deletion 25765185
nsv1108949 CNV deletion 24896259
nsv1113705 CNV deletion 24896259
nsv1121111 CNV deletion 24896259
nsv1121895 CNV deletion 24896259
nsv1125067 CNV deletion 24896259
nsv1126077 CNV deletion 24896259
nsv1126394 CNV deletion 24896259
nsv1134436 CNV deletion 24896259
nsv1138359 CNV deletion 24896259
nsv1139997 CNV deletion 24896259
nsv1141644 CNV deletion 24896259

Variation tolerance for TYRO3 Gene

Residual Variation Intolerance Score: 10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.27; 81.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TYRO3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TYRO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYRO3 Gene

Disorders for TYRO3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TYRO3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphocytic choriomeningitis
  • lcm
external ear carcinoma
  • carcinoma of external ear
retinitis pigmentosa 38
  • rp38
neurodegeneration with brain iron accumulation 6
  • copan
la crosse encephalitis
  • california encephalitis
- elite association - COSMIC cancer census association via MalaCards
Search TYRO3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TYRO3

Genetic Association Database (GAD)
TYRO3
Human Genome Epidemiology (HuGE) Navigator
TYRO3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TYRO3
genes like me logo Genes that share disorders with TYRO3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TYRO3 Gene

Publications for TYRO3 Gene

  1. Tyro3 family-mediated cell entry of Ebola and Marburg viruses. (PMID: 17005688) Shimojima M … Kawaoka Y (Journal of virology 2006) 3 4 22 60
  2. Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase. (PMID: 7537495) Toshima J … Mizuno K (Biochemical and biophysical research communications 1995) 3 4 22 60
  3. Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain. (PMID: 8108112) Ohashi K … Nakamura T (Oncogene 1994) 3 4 22 60
  4. rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. (PMID: 7511603) Mark MR … Godowski PJ (The Journal of biological chemistry 1994) 3 4 22 60
  5. Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry. (PMID: 22156524) Shimojima M … Kawaoka Y (Journal of virology 2012) 3 4 60

Products for TYRO3 Gene

  • Addgene plasmids for TYRO3

Sources for TYRO3 Gene

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