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TYRO3 Gene

protein-coding   GIFtS: 65
GCID: GC15P041851

TYRO3 Protein Tyrosine Kinase


(Previous symbol: RSE)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TYRO3 Protein Tyrosine Kinase1 2     Dtk2
RSE1 2 3     Sky2
Tyrosine-Protein Kinase BYK2 3     Tif2
Tyrosine-Protein Kinase DTK2 3     Tyrosine-Protein Kinase Receptor TYRO32
Tyrosine-Protein Kinase RSE2 3     DTK3
Tyrosine-Protein Kinase SKY2 3     SKY3
Tyrosine-Protein Kinase TIF2 3     TIF3
BYK2 3     EC 2.7.108
EC 2.7.10.13 8     

External Ids:    HGNC: 124461   Entrez Gene: 73012   Ensembl: ENSG000000924457   OMIM: 6003415   UniProtKB: Q064183   

Export aliases for TYRO3 gene to outside databases

Previous GC identifers: GC15P037219 GC15P034747 GC15P039430 GC15P039567 GC15P039638 GC15P018699


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TYRO3 Gene:
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on
chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein
S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and
phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses.
(provided by RefSeq, May 2010)

GeneCards Summary for TYRO3 Gene:
TYRO3 (TYRO3 protein tyrosine kinase) is a protein-coding gene. GO annotations related to this gene include transmembrane receptor protein tyrosine kinase activity and protein heterodimerization activity. An important paralog of this gene is AXL.

UniProtKB/Swiss-Prot: TYRO3_HUMAN, Q06418
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell
survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and
autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling
molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity.
Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of
transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron
protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important
role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which
selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3

Gene Wiki entry for TYRO3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TYRO3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTYRO3 promoter sequence
   Search Chromatin IP Primers for TYRO3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TYRO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q15.1-q21.1

TYRO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TYRO3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P041851:  view genomic region     (about GC identifiers)

Start:
41,849,873 bp from pter      End:
41,871,536 bp from pter
Size:
21,664 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TYRO3_HUMAN, Q06418 (See protein sequence)
Recommended Name: Tyrosine-protein kinase receptor TYRO3 precursor  
Size: 890 amino acids; 96905 Da
Subunit: Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 (By
similarity). Interacts with PIK3R1; this interaction increases PI3-kinase activity (By similarity)
Sequence caution: Sequence=BAA21781.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TYRO3:
1RHF (3D)    
Secondary accessions: O14953 Q86VR3

Explore the universe of human proteins at neXtProt for TYRO3: NX_Q06418

Explore proteomics data for TYRO3 at MOPED

Post-translational modifications: 

  • Autophosphorylated1
  • Ubiquitination2 at Lys582
  • Glycosylation2 at Asn63, Asn191, Asn230, Asn240, Asn293, Asn366, Asn380
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TYRO3 (Q06418) (see all 18)
     YSGDYYR  GNRLKQP  FSCEAHN  RDLAARN 


    See TYRO3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006284.2  
    ENSEMBL proteins: 
     ENSP00000454050   ENSP00000263798   ENSP00000453835   ENSP00000455441   ENSP00000452995  

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    Novus Biologicals TYRO3 Proteins
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    TYRO3 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
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    Search eBioscience for ELISAs for TYRO3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: TYRO3 protein tyrosine kinase
    TAM (or AXL) receptor family
    Axl family

    Selected InterPro protein domains (see all 12):
     IPR003598 Ig_sub2
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q06418

    ProtoNet protein and cluster: Q06418

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: TYRO3_HUMAN, Q06418
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TYRO3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYRO3_HUMAN, Q06418
    Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
    binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell
    survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and
    autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling
    molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity.
    Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of
    transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron
    protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important
    role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which
    selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for TYRO3:
    Rse tyrosine kinase 3,mainly expressed in brain,involved in the protection of neurons from apoptosis,across
    neuronal migration,expressed in neural lymphoid,vascular and reproductive tissue,involved in the regulation of
    spermatogenesis and in primary and tumor cell lines derived from these sources,receptor for and activated by GAS6
    and PROS1

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity IDA7537495
    GO:0004714transmembrane receptor protein tyrosine kinase activity NAS7511603
    GO:0004716receptor signaling protein tyrosine kinase activity NAS7511603
    GO:0005515protein binding IPI7634325
         
    Find genes that share ontologies with TYRO3           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for TYRO3:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin  Downregulation of NF-kappaB pa 
     Downregulation of NF-kappaB pa  Increased G2M DNA content  Increased cell death HMECs cel  Increased cilium length after  
     Increased number of mitotic ce 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tyro3):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  nervous system 
     reproductive system  skeleton  vision/eye 

    Find genes that share phenotypes with TYRO3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tyro3tm1Grl for TYRO3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TYRO3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TYRO3

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TYRO3 (see all 21):
    hsa-miR-15a hsa-miR-4298 hsa-miR-1302 hsa-miR-661 hsa-miR-424 hsa-miR-195 hsa-miR-15b hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidTYRO3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TYRO3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TYRO3 (NM_006293)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TYRO3
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    Addgene plasmids for TYRO3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYRO3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TYRO3_HUMAN, Q06418: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    nucleus4
    cytoskeleton2
    extracellular2
    cytosol1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005635nuclear envelope ISS--
    GO:0005789endoplasmic reticulum membrane ISS--
    GO:0005887integral component of plasma membrane NAS7511603
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with TYRO3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TYRO3 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71


    Find genes that share SuperPaths with TYRO3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TYRO3 (see all 28)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for TYRO3
        Tyrosine Kinases / Adaptors


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TYRO3
    Interactions:

        GeneGlobe Interaction Network for TYRO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for TYRO3 (Q064182, 3 ENSP000002637984) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAS6Q143933, ENSP000003318314I2D: score=4 STRING: ENSP00000331831
    PIK3R1P279863, ENSP000002743354I2D: score=3 STRING: ENSP00000274335
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    PROS1P072253, ENSP000003777834I2D: score=1 STRING: ENSP00000377783
    SRCP129313, ENSP000003509414I2D: score=3 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001779natural killer cell differentiation IEA--
    GO:0006468protein phosphorylation ----
    GO:0007155cell adhesion NAS8108112
    GO:0007165signal transduction NAS7511603
    GO:0007283spermatogenesis ISS--

    Find genes that share ontologies with TYRO3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TYRO3

    2 HMDB Compounds for TYRO3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 IUPHAR Ligands for TYRO3 (TYRO3 protein tyrosine kinase)    About this table
    LigandTypeActionAffinityPubmed IDs
    protein S
    NoneNone7867073
    growth arrest specific protein 6
    NoneNone8939948

    1 Novoseek inferred chemical compound relationship for TYRO3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 69.8 51 8108112 (5), 7511603 (5), 7559388 (3), 12029073 (2) (see all 29)



    Find genes that share compounds with TYRO3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TYRO3 gene: 
    NM_006293.3  

    Unigene Cluster for TYRO3:

    TYRO3 protein tyrosine kinase
    Hs.381282  [show with all ESTs]
    Unigene Representative Sequence: NM_006293
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559066 ENST00000263798(uc001zof.2) ENST00000560992 ENST00000560227
    ENST00000559815 ENST00000568343 ENST00000560162 ENST00000559851 ENST00000568490

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    hsa-miR-15a hsa-miR-4298 hsa-miR-1302 hsa-miR-661 hsa-miR-424 hsa-miR-195 hsa-miR-15b hsa-miR-30b*
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    GenScript: all cDNA clones in your preferred vector: TYRO3 (NM_006293)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TYRO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYRO3
    Addgene plasmids for TYRO3 
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      QuantiTect SYBR Green Assays in human, mouse, rat TYRO3
      QuantiFast Probe-based Assays in human, mouse, rat TYRO3

    Additional mRNA sequence: 

    AB209431.1 AK131389.1 AK295496.1 BC029925.2 BC034960.1 BC049368.1 BC051756.1 D17517.1 
    D50479.1 U02566.1 U05682.1 X72886.1 

    6 DOTS entries:

    DT.456425  DT.95324193  DT.100780872  DT.91967086  DT.86847119  DT.40195784 

    Selected AceView cDNA sequences (see all 156):

    U05682 BF971326 BQ432041 BC029925 BE548916 CB215759 AA912634 X72886 
    BM726763 BE907112 BC051756 BM854889 AA948255 AA502261 BQ277754 CR590956 
    D17517 AL521806 AK022124 AW263219 AU121148 CF125645 AA320962 BQ920136 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TYRO3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCGGGTCC
    TYRO3 Expression
    About this image


    TYRO3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    TYRO3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TYRO3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.381282

    UniProtKB/Swiss-Prot: TYRO3_HUMAN, Q06418
    Tissue specificity: Abundant in the brain and lower levels in other tissues

        Custom PCR Arrays for TYRO3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TYRO3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tyro31 , 5 TYRO3 protein tyrosine kinase 31, 5 87.45(n)1
    89.71(a)1
      2 (59.97 cM)5
    221741  NM_019392.21  NP_062265.21 
     1197977335 
    chicken
    (Gallus gallus)
    Aves TYRO31 TYRO3 protein tyrosine kinase 69.71(n)
    70.32(a)
      395336  NM_204627.2  NP_989958.1 
    lizard
    (Anolis carolinensis)
    Reptilia TYRO36
    TYRO3 protein tyrosine kinase
    66(a)
    1 ↔ 1
    1(41104920-41182075)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xksy2 tyrosine kinase 73.64(n)    AB022787.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dtk2 developmental receptor tyrosine kinase 75.84(n)   30709  AF021344.1 


    ENSEMBL Gene Tree for TYRO3 (if available)
    TreeFam Gene Tree for TYRO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TYRO3 gene
    AXL2  MET2  RYK2  MERTK2  MST1R2  
    Selected SIMAP similar genes for TYRO3 using alignment to 6 protein entries:     TYRO3_HUMAN (see all proteins) (see all similar genes):
    ABL1    FLT4    EPHA4    BRAF    MERTK    AXL
    MET    DDR1    RET/PTC2    MST1R    EPHA2    urf-ret
    DKFZp434L0319    FLT1    FGFR1    RET    CCDC6-RETa    CCDC6-RETc

    Find genes that share paralogs with TYRO3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TYRO3
    PGOHUM00000262065


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TYRO3 (see all 559)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1807048191,2
    --18697591(+) TCAAAA/TTGATA 1 -- us2k10--------
    rs617488091,2
    F--18697763(+) GAGAAC/TGAAAC 1 -- us2k12Minor allele frequency- T:0.02NS CSA 72
    rs1867316931,2
    C--18697794(+) AGATAC/GCTTCA 1 -- us2k11Minor allele frequency- G:0.00EU 593
    rs1911704961,2
    --18697838(+) TACAAA/GGTTCG 1 -- us2k10--------
    rs1392972871,2
    --18697839(+) ACAAGG/TTTCGC 1 -- us2k10--------
    rs1163907131,2
    C,F--18697992(+) GTAGAT/ACAGTT 1 -- us2k11Minor allele frequency- A:0.12NA 120
    rs1419059821,2
    --18698130(+) AAGAAC/TATTTT 1 -- us2k10--------
    rs2009883441,2
    --18698180(+) AAAAA-/GAAAGA 1 -- us2k10--------
    rs1837820901,2
    --18698291(+) AGGCTG/TCTGCC 1 -- us2k10--------
    rs1866975581,2
    --18698762(+) AGGGGC/TAGAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TYRO3 (41849873 - 41871536 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TYRO3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749609CNV Deletion23290073
    esv2749617CNV Deletion23290073
    esv2749611CNV Deletion23290073
    esv2749615CNV Deletion23290073
    esv2749612CNV Deletion23290073
    esv2749618CNV Deletion23290073
    esv2749614CNV Deletion23290073
    esv2749620CNV Deletion23290073
    esv2749610CNV Deletion23290073
    esv2749613CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600341    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TYRO3:
    Cancer

    Find genes that share disorders with TYRO3           About GenesLikeMe

    1 Novoseek inferred disease relationship for TYRO3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 23.1 2 15108283 (1), 15733062 (1)

    Genetic Association Database (GAD): TYRO3
    Human Genome Epidemiology (HuGE) Navigator: TYRO3 (1 document)

    Export disorders for TYRO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TYRO3 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with TYRO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RSE, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. (PubMed id 7511603)1, 2, 9 Mark M.R.... Godowski P.J. (J. Biol. Chem. 1994)
    2. Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain. (PubMed id 8108112)1, 2, 9 Ohashi K.... Nakamura T. (Oncogene 1994)
    3. Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase. (PubMed id 7537495)1, 2, 9 Toshima J.... Mizuno K. (Biochem. Biophys. Res. Commun. 1995)
    4. Tyro3 family-mediated cell entry of Ebola and Marburg viruses. (PubMed id 17005688)1, 2, 9 Shimojima M.... Kawaoka Y. (J. Virol. 2006)
    5. Association study between polymorphims in GAS6-TAM genes and carotid atherosclerosis. (PubMed id 20664904)1, 4 Hurtado B....Sala N. (Thromb. Haemost. 2010)
    6. Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. (PubMed id 20546121)1, 2 Cosemans J.M.... Heemskerk J.W. (J. Thromb. Haemost. 2010)
    7. Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family. (PubMed id 14623883)1, 2 Heiring C.... Muller Y.A. (J. Biol. Chem. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress. (PubMed id 9175267)1, 2 Kajii Y.... Onodera K. (Biol. Cell 1996)
    10. Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3. (PubMed id 7634325)1, 2 Godowski P.J....Hammonds R.G. (Cell 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7301 HGNC: 12446 AceView: TYRO3 Ensembl:ENSG00000092445 euGenes: HUgn7301
    ECgene: TYRO3 H-InvDB: TYRO3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TYRO3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TYRO3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TYRO3 gene:
    Search GeneIP for patents involving TYRO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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