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Aliases for TYMSOS Gene

Aliases for TYMSOS Gene

  • TYMS Opposite Strand 2 3 5
  • C18orf56 3 4
  • Chromosome 18 Open Reading Frame 56 2

External Ids for TYMSOS Gene

Previous HGNC Symbols for TYMSOS Gene

  • C18orf56

Summaries for TYMSOS Gene

GeneCards Summary for TYMSOS Gene

TYMSOS (TYMS Opposite Strand) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYMSOS Gene

Genomics for TYMSOS Gene

Regulatory Elements for TYMSOS Gene

Enhancers for TYMSOS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TYMSOS on UCSC Golden Path with GeneCards custom track

Promoters for TYMSOS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TYMSOS on UCSC Golden Path with GeneCards custom track

Genomic Location for TYMSOS Gene

Chromosome:
18
Start:
641,320 bp from pter
End:
658,340 bp from pter
Size:
17,021 bases
Orientation:
Minus strand

Genomic View for TYMSOS Gene

Genes around TYMSOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYMSOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYMSOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYMSOS Gene

Proteins for TYMSOS Gene

  • Protein details for TYMSOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAI1-TYMOS_HUMAN
    Recommended name:
    TYMS opposite strand protein
    Protein Accession:
    Q8TAI1
    Secondary Accessions:
    • A8K1S1

    Protein attributes for TYMSOS Gene

    Size:
    123 amino acids
    Molecular mass:
    13402 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TYMSOS Gene

Proteomics data for TYMSOS Gene at MOPED

Post-translational modifications for TYMSOS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TYMSOS Gene

REFSEQ proteins:

No data available for DME Specific Peptides for TYMSOS Gene

Domains & Families for TYMSOS Gene

Protein Domains for TYMSOS Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TYMSOS: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TYMSOS Gene

Function for TYMSOS Gene

Phenotypes for TYMSOS Gene

GenomeRNAi human phenotypes for TYMSOS:
genes like me logo Genes that share phenotypes with TYMSOS: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TYMSOS Gene

Localization for TYMSOS Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TYMSOS Gene

Pathways & Interactions for TYMSOS Gene

SuperPathways for TYMSOS Gene

No Data Available

Gene Ontology (GO) - Biological Process for TYMSOS Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TYMSOS Gene

Drugs & Compounds for TYMSOS Gene

(3) Drugs for TYMSOS Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR, Cytotoxic agent 1466
Pemetrexed Approved, Investigational Pharma TS, DHFR,GARFT and AICARFT inhibitor, DHFR and Thymidylate synthase inhibitor, Anti-Folates 587
Raltitrexed Approved, Investigational Pharma 28
genes like me logo Genes that share compounds with TYMSOS: view

Transcripts for TYMSOS Gene

mRNA/cDNA for TYMSOS Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TYMSOS Gene

No ASD Table

Relevant External Links for TYMSOS Gene

GeneLoc Exon Structure for
TYMSOS
ECgene alternative splicing isoforms for
TYMSOS

Expression for TYMSOS Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TYMSOS Gene

Orthologs for TYMSOS Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TYMSOS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C18orf56 36
  • 95 (a)
OneToOne
Species with no ortholog for TYMSOS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TYMSOS Gene

ENSEMBL:
Gene Tree for TYMSOS (if available)
TreeFam:
Gene Tree for TYMSOS (if available)

Paralogs for TYMSOS Gene

No data available for Paralogs for TYMSOS Gene

Variants for TYMSOS Gene

Sequence variations from dbSNP and Humsavar for TYMSOS Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
VAR_032162 -
rs472925 -- 655,047(-) aaggc(A/G)tgagc intron-variant
rs483599 -- 651,087(-) ATACT(C/G)TCATT intron-variant
rs491246 -- 655,052(-) gatta(A/C)aggca intron-variant
rs516864 -- 651,824(-) tggac(A/C)acatg intron-variant

Variation tolerance for TYMSOS Gene

Gene Damage Index Score: 6.93; 79.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TYMSOS Gene

Disorders for TYMSOS Gene

Relevant External Links for TYMSOS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TYMSOS

No disorders were found for TYMSOS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TYMSOS Gene

Publications for TYMSOS Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 67
  2. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  4. Protein microarray analysis identifies human cellular prion protein interactors. (PMID: 18482256) Satoh J. … Tabunoki H. (Neuropathol. Appl. Neurobiol. 2009) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for TYMSOS Gene

Sources for TYMSOS Gene

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