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Aliases for TYMSOS Gene

Aliases for TYMSOS Gene

  • TYMS Opposite Strand 2 3 5
  • C18orf56 3 4
  • Chromosome 18 Open Reading Frame 56 2
  • TYMS Opposite Strand Protein 3

External Ids for TYMSOS Gene

Previous HGNC Symbols for TYMSOS Gene

  • C18orf56

Summaries for TYMSOS Gene

GeneCards Summary for TYMSOS Gene

TYMSOS (TYMS Opposite Strand) is a Protein Coding gene.

Additional gene information for TYMSOS Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYMSOS Gene

Genomics for TYMSOS Gene

GeneHancer (GH) Regulatory Elements for TYMSOS Gene

Promoters and enhancers for TYMSOS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I000656 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 408 3.6 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TYMS ENSG00000263727 TYMSOS ENOSF1 THOC1
GH18I000708 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -52.7 -52688 4.7 FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 CBX5 E2F8 ZNF143 ENOSF1 THOC1 TYMS TYMSOS RNU1-109P YES1 ENSG00000265490
GH18I000698 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.9 -43.9 -43898 6.6 PKNOX1 FOXA2 MLX ARID4B FEZF1 ZNF2 ZNF48 ATF7 FOS KLF13 GC18M000704 PIR56960 ENOSF1 TYMS TYMSOS RNU1-109P THOC1 ENSG00000265490
GH18I000679 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 12.5 -25.0 -25017 7.9 SOX13 PKNOX1 FOXA2 SIN3A ZNF384 ZIC2 ZFHX2 LCORL RERE POLR2A ENOSF1 TYMS TYMSOS CLUL1 RNU1-109P ENSG00000265490 PIR56960 GC18M000704
GH18I000692 Enhancer 0.6 ENCODE dbSUPER 12.9 -34.9 -34886 2.2 GLIS1 ZIC2 ENOSF1 TYMSOS TYMS GC18M000704 PIR56960
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TYMSOS on UCSC Golden Path with GeneCards custom track

Genomic Locations for TYMSOS Gene

Genomic Locations for TYMSOS Gene
17,021 bases
Minus strand

Genomic View for TYMSOS Gene

Genes around TYMSOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYMSOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYMSOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYMSOS Gene

Proteins for TYMSOS Gene

  • Protein details for TYMSOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TYMS opposite strand protein
    Protein Accession:
    Secondary Accessions:
    • A8K1S1

    Protein attributes for TYMSOS Gene

    123 amino acids
    Molecular mass:
    13402 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TYMSOS Gene

Post-translational modifications for TYMSOS Gene

No Post-translational modifications

Other Protein References for TYMSOS Gene

REFSEQ proteins:

No data available for DME Specific Peptides for TYMSOS Gene

Domains & Families for TYMSOS Gene

Protein Domains for TYMSOS Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TYMSOS: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TYMSOS Gene

Function for TYMSOS Gene

Phenotypes From GWAS Catalog for TYMSOS Gene

Gene Ontology (GO) - Molecular Function for TYMSOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TYMSOS: view

Phenotypes for TYMSOS Gene

GenomeRNAi human phenotypes for TYMSOS:
genes like me logo Genes that share phenotypes with TYMSOS: view

Animal Model Products

miRNA for TYMSOS Gene

miRTarBase miRNAs that target TYMSOS

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TYMSOS Gene

Localization for TYMSOS Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TYMSOS gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TYMSOS Gene

Pathways & Interactions for TYMSOS Gene

SuperPathways for TYMSOS Gene

No Data Available

Gene Ontology (GO) - Biological Process for TYMSOS Gene


No data available for Pathways by source and SIGNOR curated interactions for TYMSOS Gene

Drugs & Compounds for TYMSOS Gene

(3) Drugs for TYMSOS Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1603
Pemetrexed Approved, Investigational Pharma TS, DHFR,GARFT and AICARFT inhibitor, DHFR and Thymidylate synthase inhibitor, Anti-Folates 674
Raltitrexed Approved, Investigational Pharma 38
genes like me logo Genes that share compounds with TYMSOS: view

Transcripts for TYMSOS Gene


(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TYMSOS Gene

No ASD Table

Relevant External Links for TYMSOS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TYMSOS Gene

NURSA nuclear receptor signaling pathways regulating expression of TYMSOS Gene:

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TYMSOS Gene

Orthologs for TYMSOS Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TYMSOS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C18orf56 34
  • 95 (a)
Species where no ortholog for TYMSOS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TYMSOS Gene

Gene Tree for TYMSOS (if available)
Gene Tree for TYMSOS (if available)

Paralogs for TYMSOS Gene

No data available for Paralogs for TYMSOS Gene

Variants for TYMSOS Gene

Sequence variations from dbSNP and Humsavar for TYMSOS Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000224379 -- 657,639(-) C/T intron_variant
rs1000354436 -- 651,835(-) G/T intron_variant
rs1001466540 -- 658,442(-) T/G upstream_transcript_variant
rs1001530949 -- 652,302(-) T/C intron_variant
rs1001554978 -- 651,947(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TYMSOS Gene

Variant ID Type Subtype PubMed ID
dgv3307n100 CNV gain 25217958
dgv5810n54 CNV gain 21841781
esv2662618 CNV deletion 23128226
esv29026 CNV loss 19812545
esv3641496 CNV loss 21293372
esv3641497 CNV gain 21293372
esv3641503 CNV gain 21293372
esv3641505 CNV loss 21293372
esv3893055 CNV gain 25118596
nsv1060188 CNV gain 25217958
nsv482935 CNV loss 15286789
nsv528169 CNV loss 19592680
nsv576228 CNV loss 21841781
nsv576236 CNV gain 21841781
nsv576239 CNV gain 21841781
nsv576242 CNV gain 21841781
nsv833577 CNV gain+loss 17160897

Variation tolerance for TYMSOS Gene

Gene Damage Index Score: 6.93; 79.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TYMSOS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYMSOS Gene

Disorders for TYMSOS Gene

Additional Disease Information for TYMSOS

No disorders were found for TYMSOS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TYMSOS Gene

Publications for TYMSOS Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  2. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. (PMID: 21244100) Virok DP … Fülöp L (Journal of proteome research 2011) 3 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 58
  4. Protein microarray analysis identifies human cellular prion protein interactors. (PMID: 18482256) Satoh J … Tabunoki H (Neuropathology and applied neurobiology 2009) 3 58
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 58

Products for TYMSOS Gene

Sources for TYMSOS Gene

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