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TYMS Gene

protein-coding   GIFtS: 73
GCID: GC18P000657

Thymidylate Synthetase


(Previous symbol: TS)
  See TYMS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thymidylate Synthetase1 2     TMS2 5
TS1 2 3 5     HST4222
TSase2 3     Thymidylate Synthase2
EC 2.1.1.453 8     

External Ids:    HGNC: 124411   Entrez Gene: 72982   Ensembl: ENSG000001768907   OMIM: 1883505   UniProtKB: P048183   

Export aliases for TYMS gene to outside databases

Previous GC identifers: GC18U990034 GC18P000645 GC18P000647


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TYMS Gene:
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using
5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime
monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for
cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil,
5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring
antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau
phase. (provided by RefSeq, Jul 2008)

GeneCards Summary for TYMS Gene:
TYMS (thymidylate synthetase) is a protein-coding gene. Diseases associated with TYMS include gastroesophageal junction adenocarcinoma, and hemifacial spasm. GO annotations related to this gene include mRNA binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: TYSY_HUMAN, P04818
Function: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway

Gene Wiki entry for TYMS (Thymidylate synthase) Gene

PharmGKB "VIP" summary for TYMS


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010859.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the TYMS gene promoter:
         AML1a   p53   ATF-2   Egr-1   RREB-1   FAC1   POU2F1   POU2F1a   ARP-1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTYMS promoter sequence
   Search Chromatin IP Primers for TYMS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TYMS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.32   Ensembl cytogenetic band:  18p11.32   HGNC cytogenetic band: 18p11.31-p11.21

TYMS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TYMS gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P000657:  view genomic region     (about GC identifiers)

Start:
657,604 bp from pter      End:
673,578 bp from pter
Size:
15,975 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TYSY_HUMAN, P04818 (See protein sequence)
Recommended Name: Thymidylate synthase  
Size: 313 amino acids; 35716 Da
Subunit: Homodimer
Selected PDB 3D structures from and Proteopedia for TYMS (see all 34):
1HVY (3D)        1HW3 (3D)        1HW4 (3D)        1HZW (3D)        1I00 (3D)        1JU6 (3D)    
Secondary accessions: Q8WYK3 Q8WYK4
Alternative splicing: 3 isoforms:  P04818-1   P04818-2   P04818-3   (Expressed only in cancerous tissues)

Explore the universe of human proteins at neXtProt for TYMS: NX_P04818

Explore proteomics data for TYMS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys77, Lys104, Lys107, Lys169, Lys292, Lys308
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TYMS (P04818) (see all 19)
     FGMQARY  MALPPCH  DRTGTGT  LLTYMIA 


    See TYMS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001062.1  
    ENSEMBL proteins: 
     ENSP00000315644   ENSP00000314902   ENSP00000314727  
    Reactome Protein details: P04818

    TYMS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for TYMS
    OriGene Protein Over-expression Lysate for TYMS
    OriGene MassSpec for TYMS
    OriGene Custom Protein Services for TYMS
    GenScript Custom Purified and Recombinant Proteins Services for TYMS
    Novus Biologicals TYMS Proteins
    Novus Biologicals TYMS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TYMS
    Cloud-Clone Corp. Proteins for TYMS

     
    Search eBioscience for Proteins for TYMS 

     
    antibodies-online proteins for TYMS (18 products) 

     
    antibodies-online peptides for TYMS

    TYMS Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TYMS
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TYMS 
    OriGene Antibodies for TYMS
    OriGene Custom Antibody Services for TYMS
    Novus Biologicals TYMS Antibodies
    Abcam antibodies for TYMS
    Cloud-Clone Corp. Antibodies for TYMS
    ThermoFisher Antibody for TYMS
    antibodies-online antibodies for TYMS (132 products) 

    TYMS Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TYMS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TYMS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TYMS
    Cloud-Clone Corp. CLIAs for TYMS
    Search eBioscience for ELISAs for TYMS 
    antibodies-online kits for TYMS (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR020940 Thymidylate_synthase_AS
     IPR023451 Thymidate_synth/dCMP_Mease
     IPR000398 Thymidylate_synthase

    Graphical View of Domain Structure for InterPro Entry P04818

    ProtoNet protein and cluster: P04818

    1 Blocks protein domain: IPB000398 Thymidylate synthase

    UniProtKB/Swiss-Prot: TYSY_HUMAN, P04818
    Similarity: Belongs to the thymidylate synthase family


    Find genes that share domains with TYMS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYSY_HUMAN, P04818
    Function: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway
    Catalytic activity: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

         Genatlas biochemistry entry for TYMS:
    thymidylate synthetase,pyrimidine biosynthetic pathway

         Enzyme Number (IUBMB): EC 2.1.1.451 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003729mRNA binding IEA--
    GO:0004799thymidylate synthase activity TAS--
    GO:0005542folic acid binding IEA--
    GO:0008144drug binding IEA--
         
    Find genes that share ontologies with TYMS           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TYMS:
     Decreased viability of wild-ty  Increased S DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TYMS

    miRNA
    Products:
        
    miRTarBase miRNAs that target TYMS:
    hsa-mir-484 (MIRT042289), hsa-mir-615-3p (MIRT040293), hsa-mir-194-5p (MIRT044879), hsa-mir-193b-3p (MIRT016485), hsa-mir-99a-5p (MIRT048693), hsa-mir-26b-5p (MIRT029608), hsa-let-7b-5p (MIRT001582), hsa-mir-18a-3p (MIRT040968), hsa-mir-34a-5p (MIRT025487)

    Block miRNA regulation of human, mouse, rat TYMS using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TYMS:
    hsa-miR-3163 hsa-miR-196a* hsa-miR-215 hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidTYMS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TYMS
    Predesigned siRNA for gene silencing in human, mouse, rat TYMS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TYMS

    Clone
    Products:
         
    OriGene clones in human, mouse for TYMS (see all 7)
    OriGene ORF clones in mouse, rat for TYMS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TYMS (NM_001071)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TYMS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYMS

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TYMS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYMS

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11502) for TYMS 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TYSY_HUMAN, P04818: Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol4
    extracellular2
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    Find genes that share ontologies with TYMS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TYMS About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1One carbon pool by folate
    One carbon pool by folate0.53
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics0.34
    One Carbon Metabolism0.53
    Antimetabolite Pathway - Folate Cycle, Pharmacodynamics0.00
    Trans-sulfuration and one carbon metabolism0.43
    dTMP de novo biosynthesis (mitochondrial)0.00
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics0.35
    2Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Pyrimidine biosynthesis0.00
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    Fluoropyrimidine Pathway, Pharmacodynamics0.00
    Pyrimidine metabolism0.33
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    pyrimidine deoxyribonucleotides biosynthesis from CTP0.00
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    pyrimidine deoxyribonucleosides salvage0.00
    pyrimidine deoxyribonucleotides de novo biosynthesis0.00
    5E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    E2F mediated regulation of DNA replication0.30
    G1/S Transition0.81
    G1/S-Specific Transcription0.00


    Find genes that share SuperPaths with TYMS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TYMS
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for TYMS
        Transcription Ligand-dependent activation of the ESR1/SP pathway

    Selected BioSystems Pathways for TYMS (see all 12)
        One Carbon Metabolism
    Fluoropyrimidine Activity
    dTMP de novo biosynthesis (mitochondrial)
    Integrated Pancreatic Cancer Pathway
    RB in Cancer

    3 Reactome Pathways for TYMS
        E2F mediated regulation of DNA replication
    Pyrimidine biosynthesis
    G1/S-Specific Transcription

    5 PharmGKB Pathways for TYMS
        Antimetabolite Pathway - Folate Cycle, Pharmacodynamics
    Fluoropyrimidine Pathway, Pharmacodynamics
    Fluoropyrimidine Pathway, Pharmacokinetics
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

    3 Kegg Pathways  (Kegg details for TYMS):
        Pyrimidine metabolism
    One carbon pool by folate
    Metabolic pathways

    UniProtKB/Swiss-Prot: TYSY_HUMAN, P04818
    Pathway: Pyrimidine metabolism; dTTP biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TYMS
    Interactions:

        GeneGlobe Interaction Network for TYMS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TYMS (P048182, 3 ENSP000003156444) via UniProtKB, MINT, STRING, and/or I2D (see all 74)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL2Q999622, 3, ENSP000003699814MINT-8270616 I2D: score=2 STRING: ENSP00000369981
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    UNGP130513, ENSP000002425764I2D: score=1 STRING: ENSP00000242576
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    PLS3P137973, ENSP000003481634I2D: score=1 STRING: ENSP00000348163
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    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0005976polysaccharide metabolic process IEA--
    GO:0006139nucleobase-containing compound metabolic process TAS2987839

    Find genes that share ontologies with TYMS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TYMS
    1 ApexBio Compound for TYMS     About this table
    CompoundAction CAS #
    PemetrexedChemotherapy agent, regulates purine and pyrimidine synthesis, therefor inhibits DNA an RNA synthesis[150399-23-8]

    Compounds for TYMS available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RisedronateFarnesyl diphosphate (FPP) synthase inhibitor[115436-72-1]
    BorrelidinAntiangiogenic; inhibits threonyl-tRNA synthetase[7184-60-3]
    AT 56L-PGDS inhibitor[162640-98-4]
    TrifluorothymidineThymidylate synthase inhibitor; induces DNA fragmentation[70-00-8]
    HQL 79Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor[162641-16-9]

    5 HMDB Compounds for TYMS    About this table
    CompoundSynonyms CAS #PubMed Ids
    5,10-Methylene-THF5,10-methylene-THF (see all 8)31690-11-6--
    5-Thymidylic acid2'-Deoxythymidine 5'-monophosphate (see all 28)365-07-1--
    Dihydrofolic acid7,8-Dihydro-L-folic acid (see all 13)4033-27-6--
    Thymidine 3',5'-cyclic monophosphate3',5'-Cyclic TMP (see all 14)6453-60-7--
    dUMP2'-Deoxy-5'-uridylate (see all 12)964-26-1--

    Selected DrugBank Compounds for TYMS (see all 19)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Trifluridine-- 70-00-8targetinhibitor18600528 18798063 15571283 20372850 16010590 17179993 14719072 19886911 6010427 15125867 11752352 19816940 4719131 16902987 6436227
    PemetrexedLY231514 (see all 2)150399-23-8targetinhibitor15795320 11742712 14596699 11763166 12571811 11752352 11252887 11531245 12023793 11524555 11848474
    RaltitrexedZD-1694 (see all 2)112887-68-0targetinhibitor10499608 10598555 10496350 10047461 10430100 10482907 11752352 10592235 18773878
    Fluorouracil5-Fluorouracil (see all 6)51-21-8targetother/unknown16609021 16719540 15353299 16596248 11752352 16563096 16538493
    enzymesubstrate16609021 16719540 15353299 16596248 11752352 16563096 16538493 21332317
    GemcitabinedFdC (see all 4)95058-81-4targetinhibitor15795320 16818496 16818276 11752352 16563096 15655942 17166391
    Trimethoprim-- 738-70-5targetinhibitor8920005 10090784 8538681 19622858 17139284 17016423 10592235
    Capecitabine-- 154361-50-9targetinhibitor15866500 16926630 15132128 11752352 15709193 15134221
    Floxuridine5 Fluorodeoxyuridine (see all 10)50-91-9target--10697524 10482907 10553409 10697523 10891536
    LeucovorinCalcium folinate (see all 7)1492-18-8targetinhibitor16251201 11752352 15025795 12453856
    2'-deoxyuridylic acid-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for TYMS gene (see all 123)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidylate 99.5 4891 18443433 (10), 1505078 (8), 7518280 (7), 8869745 (7) (see all 99)
    tomudex 96.2 303 8325888 (6), 8939755 (5), 7646540 (5), 10047461 (4) (see all 99)
    5fluorouracil 94.4 2323 7779703 (9), 15355920 (9), 7833111 (8), 11501504 (7) (see all 99)
    5-fluoro-2'-deoxyuridine-5'-monophosphate 94.2 133 12167486 (10), 1557655 (4), 16550002 (3), 7556218 (3) (see all 50)
    ag 337 93.7 103 9413945 (4), 8612303 (4), 9565579 (4), 12734319 (4) (see all 35)
    zd9331 93.2 72 9654109 (5), 9815766 (4), 10952785 (3), 15342418 (3) (see all 33)
    2'-deoxyuridine-5-monophosphate 93 111 15068368 (4), 8939755 (3), 8399157 (2), 9053905 (2) (see all 46)
    1843u89 92.7 43 8764125 (5), 16010590 (4), 9596684 (3), 8805515 (3) (see all 19)
    glycinamide ribonucleotide 92.1 87 15655941 (2), 10739873 (2), 2106831 (2), 9420020 (1) (see all 63)
    fudr 91.7 233 15918040 (4), 10975679 (4), 20079039 (4), 10891536 (3) (see all 81)

    9 PharmGKB related drug/compound annotations for TYMS gene    About this table
    Drug/compound PharmGKB Annotation
    Pyrimidine analoguesCA  
    capecitabineCA  
    fluorouracilCA  
    irinotecanCA  
    leucovorinCA  
    methotrexateCA  
    pemetrexedCA  
    raltitrexedCA  
    tegafurCA  



    Find genes that share compounds with TYMS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TYMS gene: 
    NM_001071.2  

    Unigene Cluster for TYMS:

    Thymidylate synthetase
    Hs.369762  [show with all ESTs]
    Unigene Representative Sequence: BQ056428
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000323274(uc010dka.1 uc010dkb.1 uc010dkc.1) ENST00000579128
    ENST00000323250 ENST00000323224 ENST00000584122 ENST00000581920
    miRNA
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    Block miRNA regulation of human, mouse, rat TYMS using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TYMS:
    hsa-miR-3163 hsa-miR-196a* hsa-miR-215 hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidTYMS 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TYMS
    Predesigned siRNA for gene silencing in human, mouse, rat TYMS
    Clone
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    OriGene clones in human, mouse for TYMS (see all 7)
    OriGene ORF clones in mouse, rat for TYMS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TYMS (NM_001071)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TYMS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYMS
    Primer
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    OriGene qPCR primer pairs and template standards for TYMS
    OriGene qSTAR qPCR primer pairs in human, mouse for TYMS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TYMS
      QuantiTect SYBR Green Assays in human, mouse, rat TYMS
      QuantiFast Probe-based Assays in human, mouse, rat TYMS
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11502) for TYMS 

    Additional mRNA sequence: 

    AB062290.1 AB077207.1 AB077208.1 AK223372.1 AK292620.1 AK314140.1 BC002567.2 BC013919.1 
    BC018858.2 BC083512.1 BT006811.1 X02308.1 

    Selected DOTS entries (see all 25):

    DT.91987769  DT.95139599  DT.91940417  DT.100887990  DT.121095554  DT.121095683  DT.121095715  DT.100887966 
    DT.75149969  DT.121095704  DT.92454718  DT.95249706  DT.95263539  DT.100805334  DT.100887972  DT.100887984 
    DT.100887988  DT.100887995  DT.121095691  DT.100887973  DT.108596  DT.121095668  DT.209162  DT.91833876 

    Selected AceView cDNA sequences (see all 409):

    CR611174 AL551990 CR595729 CR612332 BQ066271 BI871083 BC013919 CR605696 
    BG286957 BE280876 BM928567 AA663310 BM478045 BM843120 BQ642214 CR618525 
    BQ434233 BQ057866 CR601110 BM904778 BX343459 BM472540 CR616172 BX343458 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TYMS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTAGAGTG
    TYMS Expression
    About this image


    TYMS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
    TYMS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TYMS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369762
        Custom PCR Arrays for TYMS
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    QuantiFast Probe-based Assays in human, mouse, rat TYMS
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYMS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TYMS gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tyms1 , 5 thymidylate synthase1, 5 87.19(n)1
    90.55(a)1
      5 (15.81 cM)5
    221711  NM_021288.41  NP_067263.11 
     300582025 
    chicken
    (Gallus gallus)
    Aves TYMS1 thymidylate synthetase 79.43(n)
    84.16(a)
      421060  XM_419147.4  XP_419147.3 
    lizard
    (Anolis carolinensis)
    Reptilia TYMS6
    thymidylate synthetase
    83(a)
    1 ↔ 1
    4(39515191-39527743)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.173062 Xenopus laevis transcribed sequence with moderate similarity more 78.12(n)    BX845600.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tyms2 thymidylate synthase 77.62(n)   81540  AY005804.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ts1 , 3 deoxyribonucleotide biosynthesis
    thymidylate synthase3
    Ts1
    63(a)3
    64.4(n)1
    64.72(a)1
      23C33
    334991  NM_058019.31  NP_477367.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y110A7A.41 , 3 thymidylate synthase3
    Y110A7A.41
    68(a)3
    62.91(n)1
    68.31(a)1
      I(5138274-5139312)3
    1721491  NM_059131.51  NP_491532.31 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC21(YOR074C)4
    CDC211
    Thymidylate synthase, required for de novo biosynthesis more4
    CDC211
    60.8(n)1
    64.79(a)1
      15(467589-466675)4
    8542411, 4  NP_014717.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons THY-21 THY-2 61.54(n)
    65.73(a)
      829609  NM_119623.4  NP_195183.2 
    rice
    (Oryza sativa)
    Liliopsida Os.83072 Transcribed sequence with moderate similarity to protein more 71.27(n)    CB631384.1 


    ENSEMBL Gene Tree for TYMS (if available)
    TreeFam Gene Tree for TYMS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TYMS gene

    Find genes that share paralogs with TYMS           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for TYMS
    PGOHUM00000234291 PGOHUM00000243716


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TYMS (see all 599)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1496176931,2
    --647457(+) TGCTTA/GCAAGT 1 -- us2k10--------
    rs1450309651,2
    C--647593(+) CACAAA/GAACTA 1 -- us2k10--------
    rs588088731,2
    C--647700(+) GGCCTC/TAAGAC 1 -- us2k14Minor allele frequency- T:0.15WA NA EA 360
    rs99673681,2
    C,F,A,H--647845(+) ctattG/CatTCA 1 -- us2k123Minor allele frequency- C:0.35NS EA NA WA CSA 2338
    rs1388608051,2
    C--647917(+) AGCTAC/GTGCAA 1 -- us2k10--------
    rs1814161021,2
    --647991(+) CAGGCC/GTGTGC 1 -- us2k10--------
    rs1420731471,2
    --647995(+) CGTGTA/GCCACC 1 -- us2k10--------
    rs1149037121,2
    F--647999(+) TGCCAC/TCTCGC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1462948481,2
    --648026(+) TTTTCA/GGTAGA 1 -- us2k10--------
    rs3701232491,2
    C--648033(+) AGAGA-/CGGGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TYMS (657604 - 673578 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TYMS (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716654CNV Deletion23290073
    esv2716652CNV Deletion23290073
    esv1982616CNV Deletion18987734
    esv2521731CNV Deletion19546169
    esv2716655CNV Deletion23290073
    esv2023053CNV Deletion18987734
    esv2716653CNV Deletion23290073
    esv4728CNV Deletion18987735
    esv9315CNV Loss19470904
    nsv528169CNV Loss19592680

    Human Gene Mutation Database (HGMD): TYMS
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TYMS
    DNA2.0 Custom Variant and Variant Library Synthesis for TYMS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188350    OMIM disorders: --

    18 diseases for TYMS:    
    About MalaCards
    gastroesophageal junction adenocarcinoma    hemifacial spasm    adult acute lymphocytic leukemia    5-fluorouracil toxicity
    gallbladder cancer    rothmund-thomson syndrome    pediatric osteosarcoma    thoracic cancer
    cardia cancer    benign mesothelioma    acute lymphocytic leukemia    osteosarcoma
    colon cancer    ovarian cancer    pancreatic cancer    colorectal cancer
    breast cancer    lung cancer

    12 diseases from the University of Copenhagen DISEASES database for TYMS:
    Colorectal cancer     Carcinoma     Lung cancer     Neutropenia
    Toxic shock syndrome     Breast cancer     Diarrhea     Benign mesothelioma
    Leukemia     Malignant pleural mesothelioma     Rothmund-Thomson syndrome     Stomatitis

    Find genes that share disorders with TYMS           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TYMS gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 84.5 548 12022983 (5), 15197779 (5), 15770397 (5), 9951876 (4) (see all 99)
    colon cancer 75.8 162 10914714 (5), 17934851 (4), 10100718 (3), 16284371 (3) (see all 87)
    gastric cancer 70.1 233 11161374 (4), 17854149 (4), 19102414 (4), 10965817 (4) (see all 80)
    tumors 69 962 9048835 (10), 11179438 (8), 15309465 (7), 14576935 (6) (see all 99)
    colon carcinoma 69 55 12525515 (3), 10791849 (3), 19621386 (3), 16609021 (2) (see all 29)
    colorectal carcinoma 68.1 77 11832164 (4), 15500737 (4), 11131679 (4), 15751630 (3) (see all 34)
    colorectal tumors 64.7 27 16391809 (3), 12576451 (2), 10778957 (2), 11249590 (1) (see all 17)
    cancer 63.3 409 9126308 (5), 7647337 (5), 19155291 (5), 11410778 (4) (see all 99)
    solid tumor 61 30 14612954 (2), 19047127 (2), 11249590 (1), 15359285 (1) (see all 23)
    nsclc 59 82 15868929 (5), 10853017 (5), 14612954 (4), 17695427 (4) (see all 26)

    Genetic Association Database (GAD): TYMS
    Human Genome Epidemiology (HuGE) Navigator: TYMS (281 documents)

    Export disorders for TYMS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TYMS gene, integrated from 10 sources (see all 1904):
    (articles sorted by number of sources associating them with TYMS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer. (PubMed id 12530000)1, 4, 9 Ishida Y....Watanabe G. (Anticancer Res. 2002)
    2. Prognostic significance of the polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase gene in lung cancer. (PubMed id 16334126)1, 4, 9 Takehara A....Watanabe G. (Anticancer Res. 2005)
    3. Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. (PubMed id 15355920)1, 4, 9 Lecomte T....Laurent-Puig P. (Clin. Cancer Res. 2004)
    4. Correlation between thymidylate synthase gene variants, RNA and protein levels in primary colorectal adenocarcinomas. (PubMed id 20515563)1, 4, 9 Kristensen M.H....Mejer J. (J. Int. Med. Res. 2010)
    5. Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer. (PubMed id 19632929)1, 4, 9 Mauritz R....Peters G.J. (Clin Colorectal Cancer 2009)
    6. Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer. (PubMed id 11445856)1, 4, 9 Marsh S....McLeod H.L. (Int. J. Oncol. 2001)
    7. Association of thymidylate synthase variants with 5-fluorouracil cytotoxicity. (PubMed id 19339911)1, 4, 9 Peters E.J....McLeod H.L. (Pharmacogenet. Genomics 2009)
    8. Thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) polymorphisms in the Korean population for prediction of 5-fluorouracil-associated toxicity. (PubMed id 17417073)1, 4, 9 Cho H.J....Lee S.Y. (Ther Drug Monit 2007)
    9. Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma. (PubMed id 17659576)1, 4, 9 Yuan J.M....Yu M.C. (Hepatology 2007)
    10. Intracellular thymidylate synthase inhibition by trifluorothymidine in FM3A cells. (PubMed id 15571283)1, 7, 9 Temmink O.H....Peters G.J. (amp 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7298 HGNC: 12441 AceView: TYMS Ensembl:ENSG00000176890 euGenes: HUgn7298
    ECgene: TYMS Kegg: 7298 H-InvDB: TYMS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TYMS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TYMS Genetics and Cytogenetics in Oncology and Haematology
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TYMS

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TYMS gene:
    Search GeneIP for patents involving TYMS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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