Aliases for TYMS Gene
External Ids for TYMS Gene
Previous HGNC Symbols for TYMS Gene
Previous GeneCards Identifiers for TYMS Gene
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
GeneCards Summary for TYMS Gene
TYMS (Thymidylate Synthetase) is a Protein Coding gene. Diseases associated with TYMS include Rectal Neoplasm and Malignant Pleural Mesothelioma. Among its related pathways are E2F mediated regulation of DNA replication and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. GO annotations related to this gene include protein homodimerization activity and mRNA binding.
UniProtKB/Swiss-Prot for TYMS Gene
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.