Aliases for TYMP Gene
External Ids for TYMP Gene
Previous HGNC Symbols for TYMP Gene
Previous GeneCards Identifiers for TYMP Gene
This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
GeneCards Summary for TYMP Gene
TYMP (Thymidine Phosphorylase) is a Protein Coding gene. Diseases associated with TYMP include Mitochondrial Dna Depletion Syndrome 1 and Mitochondrial Neurogastrointestinal Encephalopathy Disease. Among its related pathways are Purine metabolism and p70S6K Signaling. GO annotations related to this gene include growth factor activity and platelet-derived growth factor receptor binding.
UniProtKB/Swiss-Prot for TYMP Gene
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.