TYK2 Gene
protein-coding GIFtS: 71
GCID: GC19M010461
|
|
tyrosine kinase 2
| |
Aliases
for TYK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tyrosine Kinase 21 2 | | JTK11 2 | | EC 2.7.10.23 8 | | Non-Receptor Tyrosine-Protein Kinase TYK22 | | EC 2.7.108 |
Export aliases for TYK2 gene to outside databasesPrevious GC identifers: GC19M010582 GC19M010684 GC19M010306 GC19M010322 GC19M010041 |
Summaries
for TYK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TYK2:
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families.This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokinesignals by phosphorylating receptor subunits. It is also component of both the type I and type III interferonsignaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associatedwith hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulinE. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TYK2_HUMAN, P29597Function: Probably involved in intracellular signal transduction by being involved in the initiation of type I IFNsignaling. Phosphorylates the interferon-alpha/beta receptor alpha chain
Gene Wiki entry for TYK2 (Tyrosine kinase 2)
|
Genomic Views
for TYK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TYK2 gene promoter:
AhR MAZR Pbx1a STAT5A E47 YY1 Arnt STAT3 ZID Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TYK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TYK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2TYK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M010461: view genomic region
(about GC identifiers)
Start:
|
10,461,204 bp from pter |
End:
|
10,491,352 bp from pter |
Size:
|
30,149 bases |
Orientation:
|
minus strand |
|
Proteins
for TYK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TYK2_HUMAN, P29597 (See
protein sequence)Recommended Name: Non-receptor tyrosine-protein kinase TYK2 Size: 1187 amino acids; 133650 Da
Subunit: Interacts with JAKMIP1
4 PDB 3D structures from  and Proteopedia  for TYK2:3LXN (3D)
3LXP (3D)
3NYX (3D)
3NZ0 (3D)
Secondary accessions: Q6QB10 Q96CH0Explore the universe of human proteins at neXtProt for TYK2: NX_P29597
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P29597
4/7 DME Specific Peptides for TYK2 (P29597) (see all 7)
TYK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003322.3
ENSEMBL proteins: ENSP00000434831 ENSP00000433203 ENSP00000431885 ENSP00000465291 ENSP00000466340 ENSP00000436155 ENSP00000432728 ENSP00000432320 ENSP00000434931 ENSP00000467288 ENSP00000436175 ENSP00000436826 ENSP00000264818 Reactome Protein details: P29597
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
TYK2 for ontologies About GeneDecksing
TYK2 Antibody Products:
Assay Products for TYK2: |
Protein
Domains /
Families
for TYK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TYK2 for domains About GeneDecksing
5/12 InterPro domains/families (see all 12):Graphical View of Domain Structure for InterPro Entry P29597ProtoNet protein and cluster: P29597 2 Blocks protein families: IPB008266 Tyrosine protein kinase IPB009127 Janus kinase family signature
UniProtKB/Swiss-Prot: TYK2_HUMAN, P29597Domain: The FERM domain mediates interaction with JAKMIP1Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamilySimilarity: Contains 1 FERM domainSimilarity: Contains 2 protein kinase domainsSimilarity: Contains 1 SH2 domain |
Function
for TYK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TYK2_HUMAN, P29597Function: Probably involved in intracellular signal transduction by being involved in the initiation of type I IFNsignaling. Phosphorylates the interferon-alpha/beta receptor alpha chainCatalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate Genatlas biochemistry entry for TYK2:tyrosine kinase 2,non receptor type,class III,expressed in lymphoid cells (JAK family),involved in signal transductionof cytokine receptors,mediating the activation of STAT proteins
Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TYK2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TYK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TYK2 (NM_003331) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TYK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYK2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
TYK2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TYK2:
Animal Models:
Mouse knock-outs for TYK2: Tyk2tm1Shmd Tyk2tm1Biat
6 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Tyk2):
TYK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TYK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/34 super-pathways (see all 34) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_PDGF signaling via STATs and NF-kB | | | 2 | Serine phosphorylation of STATs | | | 3 | Immune response IL-12-induced IFN-gamma production | | | 4 | Regulation of IFNA signaling | | | 5 | Cytokine Signaling in Immune system | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 EMD Millipore Pathways for TYK2 (see all 8)
3  R&D Systems Pathways for TYK2
5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TYK2 (see all 8)
2 
Cell Signaling Technology (CST) Pathways for TYK2
5/8  GeneGo (Thomson Reuters) Pathways for TYK2 (see all 8)
5/11  BioSystems Pathways for TYK2 (see all 11)
5/10 
Reactome Pathways for TYK2 (see all 10)
5/6 
Kegg Pathways (Kegg details for TYK2) (see all 6):
TYK2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TYK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/149 Interacting proteins for TYK2 (P295971, 2, 3 ENSP000002648184) via UniProtKB, MINT, STRING, and/or I2D (see all 149)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006468 | protein phosphorylation |
TAS | 2216457 | | GO:0007243 | intracellular protein kinase cascade |
IEA | -- | | GO:0019221 | cytokine-mediated signaling pathway |
TAS | -- | | GO:0060337 | type I interferon-mediated signaling pathway |
TAS | -- | | GO:0060338 | regulation of type I interferon-mediated signaling pathway |
TAS | -- |
TYK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TYK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TYK2 for compounds About GeneDecksing
 Browse Tocris compounds for TYK2
2 HMDB Compounds for TYK2 About this table
2 DrugBank Compounds for TYK2 About this table
10/18 Novoseek chemical compound relationships for TYK2 gene (see all 18) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
83.6 |
288 |
8780896 (5), 9822675 (4), 8628273 (3), 8055912 (3) (see all 99) |
| o-tyrosine |
80.7 |
9 |
8955182 (1), 18431049 (1), 16739993 (1), 15146413 (1) (see all 9) |
| gp 130 |
70.7 |
10 |
10491180 (2), 11772519 (2), 11294841 (1), 9388212 (1) (see all 6) |
| ifn-alpha |
70.4 |
8 |
8628273 (3), 10777558 (2), 8617715 (1), 12725866 (1) (see all 5) |
| serine |
29 |
3 |
10820390 (1), 20503468 (1), 18583177 (1) |
| wortmannin |
27.1 |
2 |
8955182 (1), 9036989 (1) |
| sodium orthovanadate |
25.9 |
1 |
7629131 (1) |
| phosphotyrosine |
24.9 |
3 |
11752426 (2), 8978300 (1) |
| ly294002 |
23.9 |
1 |
8955182 (1) |
| phosphatidylinositol |
23.8 |
2 |
9036989 (1), 10995743 (1) |
Search CenterWatch for drugs/clinical trials and news about TYK2
|
Transcripts
for TYK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TYK2 gene: NM_003331.4 Unigene Cluster for TYK2: Tyrosine kinase 2 Hs.75516 [show with all ESTs]Unigene Representative Sequence: NM_00333118/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000525976 ENST00000530220 ENST00000524462 ENST00000525621(uc002moc.4 uc010dxe.3)
ENST00000530560 ENST00000529422 ENST00000524470 ENST00000527481 ENST00000592137
ENST00000529739 ENST00000529412 ENST00000534228 ENST00000529370(uc002mod.2)
ENST00000533334 ENST00000531620 ENST00000525220 ENST00000529317 ENST00000525824
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TYK2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TYK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TYK2 (NM_003331) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TYK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYK2 |
Additional cDNA sequence: AK303627.1 AK308360.1 AK308379.1 BC014243.2 X54637.1 24/25 DOTS entries (see all 25): DT.116450 DT.121501208 DT.121501216 DT.99970969 DT.116451 DT.40268562 DT.121501229 DT.121501250 DT.92433984 DT.95360954 DT.100788359 DT.121501251 DT.95151031 DT.99990299 DT.100686528 DT.100028170 DT.100788347 DT.121501214 DT.121501219 DT.121501224 DT.121501244 DT.92433988 DT.116452 DT.91929984 24/298 AceView cDNA sequences (see all 298): AU118093 CA424811 BU162645 AI221432 BF796421 BG767031 BQ923265 BQ065744 NM_003331 BE884149 BM744416 AI190172 BP364547 BU167921 BU617220 BM703417 BM977854 BM767352 BM672908 BU170032 BM918143 BM756827 AI242302 BC014243
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for TYK2 (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c | · | 21d | · | 21e | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | · | 24c | · | 24d | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30a | · | 30b | · |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 30c | · | 30d | · | 30e |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for TYK2
|
Expression
for TYK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TYK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTCTCTGA
About this image
See TYK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TYK2
SOURCE GeneReport for Unigene cluster: Hs.75516
UniProtKB/Swiss-Prot: TYK2_HUMAN, P29597Tissue specificity: Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines
SABiosciences Expression via Pathway-Focused PCR Arrays including TYK2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TYK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TYK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TYK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TYK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYK2 |
Orthologs
for TYK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TYK2 gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TYK26 |
-- |
74(a) |
1 ↔ 1 |
Un(18386683-18388568) |
lizard
(Anolis carolinensis) |
Reptilia |
TYK26 |
-- |
60(a) |
1 ↔ 1 |
2(27847040-27886739) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.129982 |
Xenopus laevis transcribed sequence with moderate similarity more |
76.46(n) |
|
AW634099.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
tyk21 |
tyrosine kinase 2 |
58.05(n)
52.47(a) |
|
100536675 XM_003198153.1 XP_003198201.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
hop6 |
hopscotch |
19(a) |
1 → many |
X(11254932-11262130) |
ENSEMBL Gene Tree for TYK2 (if available)
TreeFam Gene Tree for TYK2 (if available) |
Paralogs
for TYK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TYK2 gene
- SYK2 TNK12 JAK22 JAK32 TNK22 ERBB42 JAK12 ERBB32
- PTK22 ERBB22 ZAP702 PTK2B2 EGFR2
18/75 SIMAP similar genes for TYK2 using alignment to 12 protein entries: TYK2_HUMAN (see all proteins)
(see all similar genes):PTK2 EZR-ROS1 FLT1 FLT4 CCDC6-RETa CCDC6-RETc
MAPK8 NTRK1 RYK BRAF JAK1 ERBB2
EGFR TXK JAK2 ABL1 GRK6 FGFR1
TYK2 for paralogs About GeneDecksing
|
Genomic Variants
for TYK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TYK2 (10461204 - 10491352 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TYK2
3 CNVs: 29686 29685 67465
Human Gene Mutation Database (HGMD): TYK2
Locus Specific Mutation Databases (LSDB): TYK2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TYK2 |
|
Disorders
/ Diseases
for TYK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TYK2 for disorders About GeneDecksing
OMIM gene information: 176941
OMIM disorders: 611521
UniProtKB/Swiss-Prot: TYK2_HUMAN, P29597
Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; alsoknown as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of aprimary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE
20/69  diseases for TYK2 (see all 69): About MalaCardshyper-ige syndrome autosomal recessive hyper ige syndrome tyrosine kinase 2 deficiency venezuelan equine encephalitis
immunodeficiency human t-cell leukemia virus type 1 severe combined immunodeficiency west nile virus
polycythemia vera dengue hemorrhagic fever hemophagocytic lymphohistiocytosis combined immunodeficiency
hemorrhagic fever japanese encephalitis myeloproliferative disorder lupus erythematosus
job's syndrome polycythemia systemic lupus erythematosus pancreatic endocrine tumors
2 diseases from the University of Copenhagen DISEASES database for TYK2:Job's syndrome Polycythemia vera 10/17 Novoseek disease relationships for TYK2 gene (see all 17) About this table
Genetic Association Database (GAD): TYK2
Human Genome Epidemiology (HuGE) Navigator: TYK2 (36 documents)
Tumor Gene Database (TGDB): TYK2
Export disorders for TYK2 gene to outside databases
|
Publications
for TYK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TYK2 gene, integrated from 9 sources (see all 370):
(articles sorted by number of sources associating them with TYK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and chromosomal mapping of new human tyrosine kinase genes. (PubMed id 2156206)1, 2, 3 Krolewski J.J.... Dalla-Favera R. (1990)
- Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. (PubMed id 15657875)1, 4, 9 Sigurdsson S....Syvanen A.C. (2005)
- TYK2, prototype of a novel class of non-receptor tyrosine kinase genes. (PubMed id 2216457)1, 2, 9 Firmbach-Kraft I....Krolewski J.J. (1990)
- Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. (PubMed id 7526154)1, 2, 9 Colamonici O.... Krolewski J. (1994)
- Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules. (PubMed id 15277531)1, 2, 9 Steindler C....Pellegrini S. (2004)
- A protein tyrosine kinase in the interferon alpha/beta signaling pathway. (PubMed id 1386289)1, 2, 9 Velazquez L.... Pellegrini S. (1992)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Putative tyrosine kinases expressed in K-562 human leukemia cells. (PubMed id 2247464)1, 2 Partanen J.... Alitalo K. (1990)
- Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells. (PubMed id 17920038)1, 9 Ide H....Horie S. (2008)
- Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. (PubMed id 8702790)1, 9 Gauzzi M.C....Pellegrini S. (1996)
|
External Searches for TYK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TYK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TYK2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TYK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TYK2 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for TYK2 | Genetics and Cytogenetics in Oncology and Haematology | | TYK2base | http://bioinf.uta.fi/TYK2base/ | | SeattleSNPs | http://pga.gs.washington.edu/data/tyk2/ |
|
| | |
About This Section
| Patent Information for TYK2 gene:
Search GeneIP for patents involving TYK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TYK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TYK2 | | OriGene shRNA RFP for TYK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TYK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TYK2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TYK2 | | OriGene 3'-UTR Clone for TYK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TYK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TYK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TYK2 | | OriGene Custom Protein Services for TYK2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TYK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TYK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TYK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TYK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TYK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TYK2 |
| |
 |  |  |  | |
| | Antibodies & Assays for TYK2 |
| | | | Search Tocris compounds for TYK2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYK2 |
|  |  |  | | | | ThermoFisher Antibodies for TYK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TYK2 |
|
|
|
|
