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Aliases for TYK2 Gene

Aliases for TYK2 Gene

  • Tyrosine Kinase 2 2 3
  • EC 2.7.10.2 4 63
  • Non-Receptor Tyrosine-Protein Kinase TYK2 3
  • EC 2.7.10 63
  • IMD35 3
  • JTK1 3

External Ids for TYK2 Gene

Summaries for TYK2 Gene

Entrez Gene Summary for TYK2 Gene

  • This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

GeneCards Summary for TYK2 Gene

TYK2 (Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with TYK2 include immunodeficiency 35 and familial atypical mycobacteriosis, tyk2-related. Among its related pathways are TGF-Beta Pathway and p70S6K Signaling. GO annotations related to this gene include protein tyrosine kinase activity and growth hormone receptor binding. An important paralog of this gene is TNK1.

UniProtKB/Swiss-Prot for TYK2 Gene

  • Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Gene Wiki entry for TYK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYK2 Gene

Genomics for TYK2 Gene

Genomic Location for TYK2 Gene

Start:
10,350,528 bp from pter
End:
10,380,676 bp from pter
Size:
30,149 bases
Orientation:
Minus strand

Genomic View for TYK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TYK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYK2 Gene

Regulatory Elements for TYK2 Gene

Proteins for TYK2 Gene

  • Protein details for TYK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29597-TYK2_HUMAN
    Recommended name:
    Non-receptor tyrosine-protein kinase TYK2
    Protein Accession:
    P29597
    Secondary Accessions:
    • Q6QB10
    • Q96CH0

    Protein attributes for TYK2 Gene

    Size:
    1187 amino acids
    Molecular mass:
    133650 Da
    Quaternary structure:
    • Interacts with JAKMIP1.

    Three dimensional structures from OCA and Proteopedia for TYK2 Gene

neXtProt entry for TYK2 Gene

Proteomics data for TYK2 Gene at MOPED

Selected DME Specific Peptides for TYK2 Gene

Post-translational modifications for TYK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for TYK2 Gene

Gene Families for TYK2 Gene

Suggested Antigen Peptide Sequences for TYK2 Gene

Graphical View of Domain Structure for InterPro Entry

P29597

UniProtKB/Swiss-Prot:

TYK2_HUMAN
Domain:
  • The FERM domain mediates interaction with JAKMIP1:
    • P29597
  • Contains 1 FERM domain.:
    • P29597
  • Contains 2 protein kinase domains.:
    • P29597
  • Contains 1 SH2 domain.:
    • P29597
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.:
    • P29597
genes like me logo Genes that share domains with TYK2: view

Function for TYK2 Gene

Molecular function for TYK2 Gene

GENATLAS Biochemistry: tyrosine kinase 2,non receptor type,class III,expressed in lymphoid cells (JAK family),involved in signal transduction of cytokine receptors,mediating the activation of STAT proteins
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Enzyme Numbers (IUBMB) for TYK2 Gene

Gene Ontology (GO) - Molecular Function for TYK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
GO:0005131 growth hormone receptor binding IPI 10502458
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TYK2: view
genes like me logo Genes that share phenotypes with TYK2: view

Animal Models for TYK2 Gene

MGI Knock Outs for TYK2:

miRNA for TYK2 Gene

miRTarBase miRNAs that target TYK2

No data available for Transcription Factor Targeting and HOMER Transcription for TYK2 Gene

Localization for TYK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TYK2 Gene COMPARTMENTS Subcellular localization image for TYK2 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 2
extracellular 2
mitochondrion 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TYK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10502458
GO:0005737 cytoplasm IDA 10502458
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with TYK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TYK2 Gene

Pathways for TYK2 Gene

genes like me logo Genes that share pathways with TYK2: view

Gene Ontology (GO) - Biological Process for TYK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 2216457
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0016477 cell migration IBA --
GO:0018108 peptidyl-tyrosine phosphorylation --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with TYK2: view

Compounds for TYK2 Gene

(2) HMDB Compounds for TYK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(18) Novoseek inferred chemical compound relationships for TYK2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 83.6 141
o-tyrosine 80.7 9
gp 130 70.7 8
ifn-alpha 70.4 8
serine 29 3
genes like me logo Genes that share compounds with TYK2: view

Transcripts for TYK2 Gene

Unigene Clusters for TYK2 Gene

Tyrosine kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TYK2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - -
SP2: - - -
SP3:
SP4: - - - -
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13:
SP14:
SP15:
SP16:

ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c · 21d · 21e ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ·
SP1: - - - - - - -
SP2:
SP3: - - - - - -
SP4:
SP5:
SP6: - -
SP7: -
SP8: - - - - - - - - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14: -
SP15: -
SP16: - - -

ExUns: 30c · 30d · 30e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TYK2 Gene

GeneLoc Exon Structure for
TYK2
ECgene alternative splicing isoforms for
TYK2

Expression for TYK2 Gene

mRNA expression in normal human tissues for TYK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TYK2 Gene

This gene is overexpressed in Whole Blood (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TYK2 Gene

SOURCE GeneReport for Unigene cluster for TYK2 Gene Hs.75516

mRNA Expression by UniProt/SwissProt for TYK2 Gene

P29597-TYK2_HUMAN
Tissue specificity: Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
genes like me logo Genes that share expressions with TYK2: view

Orthologs for TYK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TYK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TYK2 35
  • 99.06 (n)
  • 98.67 (a)
TYK2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TYK2 35
  • 85.28 (n)
  • 82.77 (a)
TYK2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TYK2 35
  • 84.45 (n)
  • 83.25 (a)
TYK2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tyk2 35
  • 80.95 (n)
  • 80.46 (a)
Tyk2 16
Tyk2 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TYK2 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tyk2 35
  • 80.72 (n)
  • 80.58 (a)
chicken
(Gallus gallus)
Aves TYK2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TYK2 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12998 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3707 35
tyk2 35
  • 63.79 (n)
  • 61.94 (a)
zebrafish
(Danio rerio)
Actinopterygii tyk2 35
  • 58.14 (n)
  • 52.91 (a)
tyk2 36
  • 50 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for TYK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TYK2 Gene

ENSEMBL:
Gene Tree for TYK2 (if available)
TreeFam:
Gene Tree for TYK2 (if available)

Paralogs for TYK2 Gene

Paralogs for TYK2 Gene

genes like me logo Genes that share paralogs with TYK2: view

Variants for TYK2 Gene

Sequence variations from dbSNP and Humsavar for TYK2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs91755 -- 10,362,894(+) acgga(G/T)tttcc intron-variant
rs166811 -- 10,370,766(+) gagcc(A/G)agatc intron-variant
rs203999 -- 10,351,823(+) aacct(C/T)cgcct intron-variant
rs280496 -- 10,352,804(+) CGCAC(C/G)GCTAG intron-variant
rs280497 -- 10,354,011(+) CCCTC(A/G)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TYK2 Gene

Variant ID Type Subtype PubMed ID
dgv3725n71 CNV Loss 21882294
dgv3726n71 CNV Loss 21882294
nsv470124 CNV Gain 18288195
nsv470125 CNV Loss 18288195
nsv518008 CNV Gain 19592680
nsv2415 CNV Insertion 18451855
esv24860 CNV Gain 19812545

Relevant External Links for TYK2 Gene

HapMap Linkage Disequilibrium report
TYK2
Human Gene Mutation Database (HGMD)
TYK2
Locus Specific Mutation Databases (LSDB)
TYK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYK2 Gene

Disorders for TYK2 Gene

(1) OMIM Diseases for TYK2 Gene (176941)

UniProtKB/Swiss-Prot

TYK2_HUMAN
  • Immunodeficiency 35 (IMD35) [MIM:611521]: A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. {ECO:0000269 PubMed:17088085}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for TYK2 Gene

(17) Novoseek inferred disease relationships for TYK2 Gene

Disease -log(P) Hits PubMed IDs
polycythemia vera 58.3 1
fibrosarcoma 50.5 6
myeloproliferative disorders 50.2 1
severe combined immunodeficiency 38.5 1
leukemia 31.9 1

Relevant External Links for TYK2

Genetic Association Database (GAD)
TYK2
Human Genome Epidemiology (HuGE) Navigator
TYK2
Tumor Gene Database (TGDB):
TYK2
genes like me logo Genes that share disorders with TYK2: view

Publications for TYK2 Gene

  1. A protein tyrosine kinase in the interferon alpha/beta signaling pathway. (PMID: 1386289) Velazquez L. … Pellegrini S. (Cell 1992) 3 4 23
  2. TYK2, prototype of a novel class of non-receptor tyrosine kinase genes. (PMID: 2216457) Firmbach-Kraft I. … Krolewski J.J. (Oncogene 1990) 3 4 23
  3. Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. (PMID: 7526154) Colamonici O. … Krolewski J. (Mol. Cell. Biol. 1994) 3 4 23
  4. Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules. (PMID: 15277531) Steindler C. … Pellegrini S. (J. Biol. Chem. 2004) 3 4 23
  5. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. (PMID: 15657875) Sigurdsson S. … Syvaenen A.-C. (Am. J. Hum. Genet. 2005) 3 23 48

Products for TYK2 Gene

  • Addgene plasmids for TYK2

Sources for TYK2 Gene

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