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TYK2 Gene

protein-coding   GIFtS: 73
GCID: GC19M010461

Tyrosine Kinase 2

  See TYK2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tyrosine Kinase 21 2
EC 2.7.10.23 8
JTK12
Non-Receptor Tyrosine-Protein Kinase TYK22
EC 2.7.108

External Ids:    HGNC: 124401   Entrez Gene: 72972   Ensembl: ENSG000001053977   OMIM: 1769415   UniProtKB: P295973   

Export aliases for TYK2 gene to outside databases

Previous GC identifers: GC19M010582 GC19M010684 GC19M010306 GC19M010322 GC19M010041


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TYK2 Gene:
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein
families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and
promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and
type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this
gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by
elevated serum immunoglobulin E. (provided by RefSeq, Jul 2008)

GeneCards Summary for TYK2 Gene:
TYK2 (tyrosine kinase 2) is a protein-coding gene. Diseases associated with TYK2 include tyrosine kinase 2 deficiency, and familial atypical mycobacteriosis, tyk2-related. GO annotations related to this gene include growth hormone receptor binding and protein tyrosine kinase activity. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: TYK2_HUMAN, P29597
Function: Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN
signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain

Gene Wiki entry for TYK2 (Tyrosine kinase 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the TYK2 gene promoter:
         AhR   MAZR   Pbx1a   STAT5A   E47   YY1   Arnt   STAT3   ZID   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTYK2 promoter sequence
   Search Chromatin IP Primers for TYK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TYK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

TYK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TYK2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010461:  view genomic region     (about GC identifiers)

Start:
10,461,204 bp from pter      End:
10,491,352 bp from pter
Size:
30,149 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TYK2_HUMAN, P29597 (See protein sequence)
Recommended Name: Non-receptor tyrosine-protein kinase TYK2  
Size: 1187 amino acids; 133650 Da
Subunit: Interacts with JAKMIP1
Selected PDB 3D structures from and Proteopedia for TYK2 (see all 11):
3LXN (3D)        3LXP (3D)        3NYX (3D)        3NZ0 (3D)        3ZON (3D)        4GFO (3D)    
Secondary accessions: Q6QB10 Q96CH0

Explore the universe of human proteins at neXtProt for TYK2: NX_P29597

Explore proteomics data for TYK2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TYK2 (P29597) (see all 7)
     RDLAARN  AARNVLL  GERLPRP  ASLMSQVS 


    See TYK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003322.3  
    ENSEMBL proteins: 
     ENSP00000434831   ENSP00000433203   ENSP00000431885   ENSP00000465291   ENSP00000466340  
     ENSP00000436155   ENSP00000432728   ENSP00000432320   ENSP00000434931   ENSP00000467288  
     ENSP00000436175   ENSP00000436826   ENSP00000264818  
    Reactome Protein details: P29597

    TYK2 Human Recombinant Protein Products:

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    Novus Biologicals TYK2 Protein
    Novus Biologicals TYK2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TYK2 

     
    antibodies-online proteins for TYK2 (3 products) 

     
    antibodies-online peptides for TYK2

    TYK2 Antibody Products:

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    antibodies-online antibodies for TYK2 (130 products) 

    TYK2 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TYK2 
    antibodies-online kits for TYK2 (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: tyrosine kinase 2
    Janus kinase (JakA) family

    Selected InterPro protein domains (see all 12):
     IPR019748 FERM_central
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P29597

    ProtoNet protein and cluster: P29597

    2 Blocks protein domains:
    IPB008266 Tyrosine protein kinase
    IPB009127 Janus kinase family signature


    UniProtKB/Swiss-Prot: TYK2_HUMAN, P29597
    Domain: The FERM domain mediates interaction with JAKMIP1
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily
    Similarity: Contains 1 FERM domain
    Similarity: Contains 2 protein kinase domains
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with TYK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYK2_HUMAN, P29597
    Function: Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN
    signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for TYK2:
    tyrosine kinase 2,non receptor type,class III,expressed in lymphoid cells (JAK family),involved in signal
    transduction of cytokine receptors,mediating the activation of STAT proteins

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005131growth hormone receptor binding IPI10502458
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with TYK2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TYK2:
     Decreased substrate adherent c  Increased cell death HMECs cel  Increased mitotic index 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tyk2):
     adipose tissue  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  skeleton 

    Find genes that share phenotypes with TYK2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TYK2: Tyk2tm1Shmd Tyk2tm1Biat

       genOway: Develop your customized and physiologically relevant rodent model for TYK2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TYK2:
    hsa-mir-124-3p (MIRT023017)

    Block miRNA regulation of human, mouse, rat TYK2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TYK2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidTYK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TYK2
    Predesigned siRNA for gene silencing in human, mouse, rat TYK2

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for TYK2
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    GenScript: all cDNA clones in your preferred vector: TYK2 (NM_003331)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TYK2
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    Addgene plasmids for TYK2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TYK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton2
    extracellular2
    mitochondrion2
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10502458
    GO:0005737cytoplasm IDA10502458
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with TYK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TYK2 About   (see all 33)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response IL 23 signaling pathway
    Immune response IL 23 signaling pathway0.41
    Immune response IL 10 signaling pathway0.38
    Development PDGF signaling via STATs and NF kB0.41
    IL23-mediated signaling events0.38
    2Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    Regulation of IFNA signaling0.69
    3IL-9 Signaling Pathways
    IL-4 Signaling Pathways0.84
    IL-9 Signaling Pathway0.42
    4Th1 Differentiation
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38
    5IL12-mediated signaling events
    Immune response IL 12 induced IFN gamma production0.33
    IL12-mediated signaling events0.33


    Find genes that share SuperPaths with TYK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for TYK2
        IL-4 Signaling Pathways
    Th1 Differentiation
    Th17 Differentiation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TYK2 (see all 8)
        STAT3 Pathway
    IL-10 Pathway
    CNTF Signaling
    Interferon Pathway
    JAK-STAT Pathway

    2 Cell Signaling Technology (CST) Pathways for TYK2
        Tyrosine Kinases / Adaptors
    Jak/Stat Pathway

    Selected GeneGo (Thomson Reuters) Pathways for TYK2 (see all 8)
        Development PDGF signaling via STATs and NF-kB
    Immune response IL-12 signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response IL-22 signaling pathway
    Immune response IL-12-induced IFN-gamma production

    Selected BioSystems Pathways for TYK2 (see all 13)
        Oncostatin M Signaling Pathway
    Interferon type I
    IL-4 signaling Pathway
    IL-6 Signaling Pathway
    IL-9 Signaling Pathway

    3 Reactome Pathways for TYK2
        Regulation of IFNA signaling
    Interleukin-6 signaling
    Interferon alpha/beta signaling


    Selected Kegg Pathways  (Kegg details for TYK2) (see all 8):
        Osteoclast differentiation
    Jak-STAT signaling pathway
    Toxoplasmosis
    Hepatitis C
    Measles

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TYK2: 
              Innate & Adaptive Immune Responses in human mouse rat
              Th1/Th2 Response in human mouse rat
              Type I Interferon Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TYK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TYK2 (P295971, 2, 3 ENSP000002648184) via UniProtKB, MINT, STRING, and/or I2D (see all 162)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFNAR1P171812, 3, ENSP000002701394MINT-73134 I2D: score=6 STRING: ENSP00000270139
    TK1P041832, 3MINT-8274324 I2D: score=2 
    PTPN1P180312, 3, ENSP000003606834MINT-6793782 I2D: score=4 STRING: ENSP00000360683
    PRKCAP172522, 3, ENSP000002843844MINT-4507312 I2D: score=1 STRING: ENSP00000284384
    DNM2P505702, 3, ENSP000003527214MINT-8254499 I2D: score=2 STRING: ENSP00000352721
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS2216457
    GO:0018108peptidyl-tyrosine phosphorylation TAS2216457
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0035556intracellular signal transduction IEA--
    GO:0060337type I interferon signaling pathway TAS--

    Find genes that share ontologies with TYK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TYK2

    2 HMDB Compounds for TYK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for TYK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE-- --target--10592235
    3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for TYK2 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 83.6 288 8780896 (5), 9822675 (4), 8628273 (3), 8055912 (3) (see all 99)
    o-tyrosine 80.7 9 8955182 (1), 18431049 (1), 16739993 (1), 15146413 (1) (see all 9)
    gp 130 70.7 10 10491180 (2), 11772519 (2), 11294841 (1), 9388212 (1) (see all 6)
    ifn-alpha 70.4 8 8628273 (3), 10777558 (2), 8617715 (1), 12725866 (1) (see all 5)
    serine 29 3 10820390 (1), 20503468 (1), 18583177 (1)
    wortmannin 27.1 2 8955182 (1), 9036989 (1)
    sodium orthovanadate 25.9 1 7629131 (1)
    phosphotyrosine 24.9 3 11752426 (2), 8978300 (1)
    ly294002 23.9 1 8955182 (1)
    phosphatidylinositol 23.8 2 9036989 (1), 10995743 (1)



    Find genes that share compounds with TYK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TYK2 gene: 
    NM_003331.4  

    Unigene Cluster for TYK2:

    Tyrosine kinase 2
    Hs.75516  [show with all ESTs]
    Unigene Representative Sequence: NM_003331
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000525976 ENST00000530220 ENST00000524462 ENST00000525621(uc002moc.4 uc010dxe.3)
    ENST00000530560 ENST00000529422 ENST00000524470 ENST00000527481 ENST00000592137
    ENST00000529739 ENST00000529412 ENST00000534228 ENST00000529370(uc002mod.2)
    ENST00000533334 ENST00000531620 ENST00000525220 ENST00000529317 ENST00000525824

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate TYK2:
    hsa-miR-124 hsa-miR-506
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TYK2 (NM_003331)
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    OriGene qSTAR qPCR primer pairs in human, mouse for TYK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TYK2
      QuantiTect SYBR Green Assays in human, mouse, rat TYK2
      QuantiFast Probe-based Assays in human, mouse, rat TYK2

    Additional mRNA sequence: 

    AK303627.1 AK308360.1 AK308379.1 BC014243.2 X54637.1 

    Selected DOTS entries (see all 25):

    DT.116450  DT.121501208  DT.121501216  DT.99970969  DT.116451  DT.40268562  DT.121501229  DT.121501250 
    DT.92433984  DT.95360954  DT.100788359  DT.121501251  DT.95151031  DT.99990299  DT.100686528  DT.100028170 
    DT.100788347  DT.121501214  DT.121501219  DT.121501224  DT.121501244  DT.92433988  DT.116452  DT.91929984 

    Selected AceView cDNA sequences (see all 298):

    BF796421 AI221432 BM918143 BE884149 BQ065744 BM756896 BM977854 CA389537 
    BQ638433 BU729348 BI333421 AI190172 BM672908 BP364547 BM756827 BM744416 
    AI929254 AU118093 BQ002648 BF878645 BG059938 BM771034 BM767250 NM_003331 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TYK2 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:                                                              -     -     -                                                                                 
    SP2:                                                              -     -     -                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                -                             -     -     -                                                                                 
    SP5:                                                                          -                                                                                 

    ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c · 21d · 21e ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ·
    SP1:                                      -     -                                         -     -           -                       -     -                     
    SP2:                                                                                                                                                            
    SP3:                                                                                -     -     -           -                       -     -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 30c · 30d · 30e
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TYK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TYK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCTCTGA
    TYK2 Expression
    About this image


    TYK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Lung (Respiratory System)
     
     Umbilical Cord (Extraembryonic Tissues)
     
     Spleen (Hematopoietic System)
    TYK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TYK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75516

    UniProtKB/Swiss-Prot: TYK2_HUMAN, P29597
    Tissue specificity: Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell
    lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TYK2: 
              Innate & Adaptive Immune Responses in human mouse rat
              Th1/Th2 Response in human mouse rat
              Type I Interferon Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for TYK2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tyk21 , 5 tyrosine kinase 21, 5 80.95(n)1
    80.46(a)1
      9 (7.71 cM)5
    547211  NM_001205312.11  NP_001192241.11 
     211040695 
    chicken
    (Gallus gallus)
    Aves TYK26
    tyrosine kinase 2
    62(a)
    1 ↔ 1
    AADN03014784.1(21-7899)
    lizard
    (Anolis carolinensis)
    Reptilia TYK26
    tyrosine kinase 2
    63(a)
    1 ↔ 1
    2(27842966-27900265)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.129982 Xenopus laevis transcribed sequence with moderate similarity more 76.46(n)    AW634099.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tyk21 tyrosine kinase 2 58.14(n)
    52.91(a)
      100536675  XM_003198153.2  XP_003198201.2 


    ENSEMBL Gene Tree for TYK2 (if available)
    TreeFam Gene Tree for TYK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TYK2 gene
    SYK2  TNK12  JAK32  JAK22  TNK22  ERBB42  JAK12  ERBB32  
    PTK22  ERBB22  ZAP702  EGFR2  PTK2B2  
    Selected SIMAP similar genes for TYK2 using alignment to 12 protein entries:     TYK2_HUMAN (see all proteins) (see all similar genes):
    NTRK3    PTK2    EZR-ROS1    FLT1    FLT4    LRIG3(NM_001136051)-ROS1
    LRIG3(NM_153377)-ROS1    R32    R34    SLC34A2-ROS1    TPM3-ROS1    CCDC6-RETa
    CCDC6-RETc    MAPK8    R11    R12    NTRK1    BRAF

    Find genes that share paralogs with TYK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TYK2 (see all 955)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0418724
    A colorectal adenocarcinoma sample4--see VAR_0418722 H R mis40--------
    rs127203381,2
    C,F,H--10460794(-) ATTGCG/ACCTGG 1 -- ds50017Minor allele frequency- A:0.01NS NA 572
    rs127203631,2
    C,F--10460939(-) gtgacC/Tgcctc 1 -- ds50017Minor allele frequency- T:0.00NS MN 482
    rs5963661,2
    C,F--10460943(+) CGGTCA/GCCTGT 1 -- ds50017Minor allele frequency- G:0.32NS MN 486
    rs127203371,2
    C--10460945(-) CTACAG/AGTGAC 1 -- ds50017Minor allele frequency- A:0.00NS MN 486
    rs1436415631,2
    --10461030(+) ACGCCA/GCTGCA 1 -- ds50010--------
    rs1863547421,2
    --10461062(+) AAGACG/TCTGTC 1 -- ds50010--------
    rs347233801,2
    C,F--10461076(-) TTTTTT/GCTTTT 1 -- ds50015Minor allele frequency- G:0.04MN 396
    rs127203621,2
    C,F--10461077(-) tttttT/Gtcttt 1 -- ds50017Minor allele frequency- G:0.01NS MN 486
    rs127203361,2
    H--10461209(-) TCTCTG/CCTGGA 1 -- ut31 ese36Minor allele frequency- C:0.00NS EA 508

    HapMap Linkage Disequilibrium report for TYK2 (10461204 - 10491352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TYK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2415CNV Insertion18451855
    nsv470125CNV Loss18288195
    dgv3726n71CNV Loss21882294
    dgv3725n71CNV Loss21882294
    nsv518008CNV Gain19592680
    nsv470124CNV Gain18288195
    esv24860CNV Gain19812545

    Human Gene Mutation Database (HGMD): TYK2
    Locus Specific Mutation Databases (LSDB): TYK2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TYK2
    DNA2.0 Custom Variant and Variant Library Synthesis for TYK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 176941   
    OMIM disorders: 611521  
    UniProtKB/Swiss-Prot: TYK2_HUMAN, P29597
  • Protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]: Consists of a primary
    immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 9 diseases for TYK2:    
    About MalaCards
    tyrosine kinase 2 deficiency    familial atypical mycobacteriosis, tyk2-related    hyper ige syndrome    gallbladder adenocarcinoma
    venezuelan equine encephalitis    subacute cutaneous lupus erythematosus    oligoarticular juvenile arthritis    polyarticular onset juvenile idiopathic arthritis
    polycythemia vera

    2 diseases from the University of Copenhagen DISEASES database for TYK2:
    Job's syndrome     Polycythemia vera

    Find genes that share disorders with TYK2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TYK2 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polycythemia vera 58.3 1 16239216 (1)
    fibrosarcoma 50.5 8 9305869 (2), 7537214 (1), 9794795 (1), 9013940 (1) (see all 5)
    myeloproliferative disorders 50.2 1 16867903 (1)
    severe combined immunodeficiency 38.5 2 19290934 (1)
    leukemia 31.9 1 16193102 (1)
    myeloma 18.5 1 10673353 (1)
    autoimmune diseases 17.1 2 16239216 (1), 14500783 (1)
    lupus erythematosus systemic 2.87 7 17384181 (2), 15657875 (1), 19440814 (1), 19567624 (1)
    lung tumor 0 1 11127821 (1)
    prostate carcinoma 0 1 10660600 (1)

    Genetic Association Database (GAD): TYK2
    Human Genome Epidemiology (HuGE) Navigator: TYK2 (36 documents)
    Tumor Gene Database (TGDB): TYK2

    Export disorders for TYK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TYK2 gene, integrated from 10 sources (see all 383):
    (articles sorted by number of sources associating them with TYK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and chromosomal mapping of new human tyrosine kinase genes. (PubMed id 2156206)1, 2, 3 Krolewski J.J.... Dalla-Favera R. (Oncogene 1990)
    2. Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families. (PubMed id 17384181)1, 4, 9 Cunninghame Graham D.S....Vyse T.J. (Rheumatology (Oxford) 2007)
    3. Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population. (PubMed id 19440814)1, 4, 9 Kyogoku C....Kumagai S. (Mod Rheumatol 2009)
    4. Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus. (PubMed id 19567624)1, 4, 9 Hellquist A....Kere J. (J. Rheumatol. 2009)
    5. Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. (PubMed id 19293837)1, 4, 9 Ban M....Compston A. (Eur. J. Hum. Genet. 2009)
    6. Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the Japanese population. (PubMed id 19653082)1, 4, 9 Sato K....Tsukamoto K. (J. Clin. Immunol. 2009)
    7. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. (PubMed id 15657875)1, 4, 9 Sigurdsson S....Syvaenen A.-C. (Am. J. Hum. Genet. 2005)
    8. TYK2, prototype of a novel class of non-receptor tyrosine kinase genes. (PubMed id 2216457)1, 2, 9 Firmbach-Kraft I....Krolewski J.J. (Oncogene 1990)
    9. Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. (PubMed id 7526154)1, 2, 9 Colamonici O.... Krolewski J. (Mol. Cell. Biol. 1994)
    10. A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon I+. (PubMed id 20065083)1, 4, 9 Kreil S....Cross N.C. (Haematologica 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7297 HGNC: 12440 AceView: TYK2 Ensembl:ENSG00000105397 euGenes: HUgn7297
    ECgene: TYK2 Kegg: 7297 H-InvDB: TYK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TYK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TYK2 Genetics and Cytogenetics in Oncology and Haematology
    TYK2basehttp://bioinf.uta.fi/TYK2base/
    SeattleSNPshttp://pga.gs.washington.edu/data/tyk2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TYK2 gene:
    Search GeneIP for patents involving TYK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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