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Aliases for TXNRD3NB Gene

Aliases for TXNRD3NB Gene

  • Thioredoxin Reductase 3 Neighbor 2 3 5
  • Thioredoxin Reductase 3 Intronic Transcript 1 2 3 4
  • Thioredoxin Reductase 3 New Transcript 1 2 3 4
  • Thioredoxin Reductase 2 Intronic Transcript 1 3 4
  • Thioredoxin Reductase 3 Neighbor Gene Protein 3 4
  • TXNRD3 Neighbor Gene Protein 3 4
  • TXNRD3IT1 3 4
  • TXNRD3NT1 3 4
  • TR2IT1 3 4

External Ids for TXNRD3NB Gene

Previous HGNC Symbols for TXNRD3NB Gene


Previous GeneCards Identifiers for TXNRD3NB Gene

  • GC03M126291

Summaries for TXNRD3NB Gene

GeneCards Summary for TXNRD3NB Gene

TXNRD3NB (Thioredoxin Reductase 3 Neighbor) is a Protein Coding gene. Among its related pathways are Selenium Pathway and Selenium Metabolism and Selenoproteins.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNRD3NB Gene

Genomics for TXNRD3NB Gene

Genomic Location for TXNRD3NB Gene

126,571,779 bp from pter
126,608,555 bp from pter
36,777 bases
Minus strand

Genomic View for TXNRD3NB Gene

Genes around TXNRD3NB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNRD3NB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNRD3NB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNRD3NB Gene

No data available for Regulatory Elements for TXNRD3NB Gene

Proteins for TXNRD3NB Gene

  • Protein details for TXNRD3NB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TXNRD3NB
    Protein Accession:

    Protein attributes for TXNRD3NB Gene

    133 amino acids
    Molecular mass:
    14331 Da
    Quaternary structure:
    No Data Available
    • The gene encoding this protein shares overlapping exons with TXNRD3. The initiation codon is found in exon 3 of the TXNRD3IT1 gene.

neXtProt entry for TXNRD3NB Gene

Proteomics data for TXNRD3NB Gene at MOPED

Post-translational modifications for TXNRD3NB Gene

No Post-translational modifications

Other Protein References for TXNRD3NB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TXNRD3NB Gene

Domains & Families for TXNRD3NB Gene

Protein Domains for TXNRD3NB Gene


Suggested Antigen Peptide Sequences for TXNRD3NB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TXNRD3NB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TXNRD3NB Gene

Function for TXNRD3NB Gene

Phenotypes for TXNRD3NB Gene

GenomeRNAi human phenotypes for TXNRD3NB:
genes like me logo Genes that share phenotypes with TXNRD3NB: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNRD3NB Gene

Localization for TXNRD3NB Gene

Subcellular locations from

Jensen Localization Image for TXNRD3NB Gene COMPARTMENTS Subcellular localization image for TXNRD3NB gene
Compartment Confidence
extracellular 3
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TXNRD3NB Gene

Pathways & Interactions for TXNRD3NB Gene

genes like me logo Genes that share pathways with TXNRD3NB: view

Pathways by source for TXNRD3NB Gene

2 BioSystems pathways for TXNRD3NB Gene

Interacting Proteins for TXNRD3NB Gene

Gene Ontology (GO) - Biological Process for TXNRD3NB Gene


No data available for SIGNOR curated interactions for TXNRD3NB Gene

Drugs & Compounds for TXNRD3NB Gene

No Compound Related Data Available

Transcripts for TXNRD3NB Gene


(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNRD3NB Gene

No ASD Table

Relevant External Links for TXNRD3NB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNRD3NB Gene

mRNA expression in normal human tissues for TXNRD3NB Gene

Protein differential expression in normal tissues from HIPED for TXNRD3NB Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TXNRD3NB Gene

mRNA Expression by UniProt/SwissProt for TXNRD3NB Gene

Tissue specificity: Expressed in pancreas, esophagus, bone marrow and keratinocytes.
genes like me logo Genes that share expression patterns with TXNRD3NB: view

Protein tissue co-expression partners for TXNRD3NB Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TXNRD3NB Gene

Orthologs for TXNRD3NB Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TXNRD3NB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TXNRD3NB 36
  • 96 (a)
Species with no ortholog for TXNRD3NB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TXNRD3NB Gene

Gene Tree for TXNRD3NB (if available)
Gene Tree for TXNRD3NB (if available)

Paralogs for TXNRD3NB Gene

No data available for Paralogs for TXNRD3NB Gene

Variants for TXNRD3NB Gene

Sequence variations from dbSNP and Humsavar for TXNRD3NB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs16837634 -- 126,605,542(+) GTCTT(C/T)GGGTT intron-variant
rs73195872 -- 126,605,546(+) TTGGG(A/T)TTCTA intron-variant
rs146248821 -- 126,605,807(+) TCCAC(C/T)ATAAC intron-variant
rs141374567 -- 126,605,363(+) TGAGA(A/C)CAGGC intron-variant
rs140063122 -- 126,606,367(+) TCTGT(C/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNRD3NB Gene

Variant ID Type Subtype PubMed ID
nsv877432 CNV Loss 21882294
nsv829717 CNV Loss 17160897
dgv5246n71 CNV Loss 21882294

Variation tolerance for TXNRD3NB Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNRD3NB Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNRD3NB Gene

Disorders for TXNRD3NB Gene

Relevant External Links for TXNRD3NB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TXNRD3NB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNRD3NB Gene

Publications for TXNRD3NB Gene

  1. Identification and characterization of novel variants of the thioredoxin reductase 3 new transcript 1 TXNRD3NT1. (PMID: 15674732) Matsuzaka Y. … Inoko H. (Mamm. Genome 2005) 2 3 4 67
  2. Identification, expression analysis and polymorphism of a novel RLTPR gene encoding a RGD motif, tropomodulin domain and proline/leucine- rich regions. (PMID: 15588584) Matsuzaka Y. … Inoko H. (Gene 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TXNRD3NB Gene

Sources for TXNRD3NB Gene

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