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TXNRD3NB Gene

protein-coding   GIFtS: 26
GCID: GC03M126291

Thioredoxin Reductase 3 Neighbor

(Previous name: thioredoxin reductase 3 intronic transcript 1)
(Previous symbol: TXNRD3IT1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin Reductase 3 Neighbor1 2     Thioredoxin Reductase 3 Neighbor Gene Protein2 3
Thioredoxin Reductase 3 Intronic Transcript 11 2 3     TR2IT12 3
TXNRD3IT11 2 3     TXNRD3NT12 3
Thioredoxin Reductase 3 New Transcript 11 2 3     TXNRD3 Neighbor Gene Protein2 3
Thioredoxin Reductase 2 Intronic Transcript 12 3     Protein TXNRD3NB2

External Ids:    HGNC: 338701   Entrez Gene: 6458402   Ensembl: ENSG000002064837   UniProtKB: Q6F5E73   

Export aliases for TXNRD3NB gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TXNRD3NB Gene:
TXNRD3NB (thioredoxin reductase 3 neighbor) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for TXNRD3NB
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXNRD3NB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

TXNRD3NB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNRD3NB gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M126291:  view genomic region     (about GC identifiers)

Start:
126,290,622 bp from pter      End:
126,327,398 bp from pter
Size:
36,777 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TR3N_HUMAN, Q6F5E7 (See protein sequence)
Recommended Name: Protein TXNRD3NB  
Size: 133 amino acids; 14331 Da
Miscellaneous: The gene encoding this protein shares overlapping exons with TXNRD3. The initiation codon is found
in exon 3 of the TXNRD3IT1 gene

Explore the universe of human proteins at neXtProt for TXNRD3NB: NX_Q6F5E7

Explore proteomics data for TXNRD3NB at MOPED


See TXNRD3NB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001034872.1  
ENSEMBL proteins: 
 ENSP00000384071   ENSP00000373066  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q6F5E7


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for TXNRD3NB

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TXNRD3NB About    
See pathways by source

SuperPathContained pathways About
1Selenium Pathway
Selenium Pathway
2Selenium Metabolism and Selenoproteins
Selenium Metabolism and Selenoproteins


2 BioSystems Pathways for TXNRD3NB
    Selenium Metabolism and Selenoproteins
Selenium Pathway


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Interactions:

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for TXNRD3NB (TR3N)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TXNRD3NB gene: 
NM_001039783.1  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000404489 ENST00000383572
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TXNRD3NB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TXNRD3NB Expression
About this image

TXNRD3NB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TXNRD3NB Protein Expression

UniProtKB/Swiss-Prot: TR3N_HUMAN, Q6F5E7
Tissue specificity: Expressed in pancreas, esophagus, bone marrow and keratinocytes

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for TXNRD3NB gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia TXNRD3NB6
thioredoxin reductase 3 neighbor
96(a)
1 ↔ 1
3(129957039-129957738)


ENSEMBL Gene Tree for TXNRD3NB (if available)
TreeFam Gene Tree for TXNRD3NB (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TXNRD3NB (see all 635)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1126975001,2
F--126290154(+) AGCTGC/TCTGAG 1 -- int11Minor allele frequency- T:0.50CSA 2
rs616176631,2
C--126290429(+) TCAAGG/CTCAGC 1 -- int11Minor allele frequency- C:0.50WA 2
rs1400916801,2
--126290460(+) CCCTGA/CCCCAC 1 -- int10--------
rs1432822311,2
C--126290509(+) CCAAA-/GGCCATAC 1 -- int10--------
rs787548851,2
C,F--126290529(+) GCCTAC/TTGTCT 1 -- int11Minor allele frequency- T:0.03NA 120
rs1833428681,2
--126290574(+) GCCAAA/TGGTGA 1 -- int10--------
rs1876810211,2
C--126290666(+) TTGTAC/TCTGGT 1 -- ut310--------
rs1452743231,2
--126290803(+) GTGGTA/GTTTGT 1 -- ut310--------
rs1998956431,2
C--126290838(+) AGCCAC/TTGGGT 1 -- ut310--------
rs1931581071,2
C--126290841(+) CATTGC/GGTGTA 1 -- ut310--------

HapMap Linkage Disequilibrium report for TXNRD3NB (126290622 - 126327398 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TXNRD3NB:    About this table    
Variant IDTypeSubtypePubMed ID
dgv5246n71CNV Loss21882294
nsv877432CNV Loss21882294
nsv829717CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TXNRD3NB gene integrated from 10 sources:
(articles sorted by number of sources associating them with TXNRD3NB)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of novel variants of the thioredoxin reductase 3 new transcript 1 TXNRD3NT1. (PubMed id 15674732)1, 2, 3 Matsuzaka Y.... Inoko H. (Mamm. Genome 2005)
  2. Identification, expression analysis and polymorphism of a novel RLTPR gene encoding a RGD motif, tropomodulin domain and proline/leucine- rich regions. (PubMed id 15588584)1 Matsuzaka Y.... Inoko H. (Gene 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 645840 HGNC: 33870 Ensembl:ENSG00000206483 euGenes: HUgn645840 ECgene: TXNRD3NB
H-InvDB: TXNRD3NB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TXNRD3NB Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TXNRD3NB gene:
Search GeneIP for patents involving TXNRD3NB

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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