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TXNRD3 Gene

protein-coding   GIFtS: 50
GCID: GC03M126292

Thioredoxin Reductase 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin Reductase 31 2     TGR2 3
TRXR32 3 5     EC 1.8.1.93 8
Thioredoxin Glutathione Reductase1 2     TR22 5
Thioredoxin And Glutathione Reductase2 3     Thioredoxin Reductase 22
Thioredoxin Reductase TR22 3     EC 1.8.18

External Ids:    HGNC: 206671   Entrez Gene: 1141122   Ensembl: ENSG000001977637   OMIM: 6062355   UniProtKB: Q86VQ63   

Export aliases for TXNRD3 gene to outside databases

Previous GC identifers: GC03M127607 GC03M127646 GC03M127808 GC03U901368 GC03M126327 GC03M123706


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TXNRD3 Gene:
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the
reduction of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine
(Sec) residue (which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal
position. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence
(SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively
spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Mar
2010)

GeneCards Summary for TXNRD3 Gene:
TXNRD3 (thioredoxin reductase 3) is a protein-coding gene. GO annotations related to this gene include electron carrier activity and NADP binding. An important paralog of this gene is TXNRD1.

UniProtKB/Swiss-Prot: TRXR3_HUMAN, Q86VQ6
Function: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide
bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role
in sperm maturation by promoting formation of sperm structural components (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TXNRD3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TXNRD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXNRD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3p13-q13.33

TXNRD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNRD3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M126292:  view genomic region     (about GC identifiers)

Start:
126,290,622 bp from pter      End:
126,373,998 bp from pter
Size:
83,377 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRXR3_HUMAN, Q86VQ6 (See protein sequence)
Recommended Name: Thioredoxin reductase 3  
Size: 643 amino acids; 70683 Da
Cofactor: Binds 1 FAD per subunit (By similarity)
Subunit: Homodimer (By similarity)
Miscellaneous: The thioredoxin reductase active site is a redox-active disulfide bond. The selenocysteine residue
is also essential for catalytic activity (By similarity)
Caution: This sequence initiates at a CTG codon (PubMed:20018845)
Sequence caution: Sequence=AAH30028.1; Type=Erroneous termination; Positions=642; Note=Translated as Sec;
Sequence=AAH30028.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by
a non-canonical CTG leucine codon; Sequence=AAH50032.1; Type=Erroneous termination; Positions=642;
Note=Translated as Sec; Sequence=AAH50032.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The
initiator methionine is coded by a non-canonical CTG leucine codon;
1 PDB 3D structure from and Proteopedia for TXNRD3:
3H8Q (3D)    
Secondary accessions: Q6PIS8 Q9NNW6 Q9P101

Explore the universe of human proteins at neXtProt for TXNRD3: NX_Q86VQ6

Explore proteomics data for TXNRD3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys601
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TXNRD3 (Q86VQ6) (see all 13)
     IGGGSGG  LGPNAGE  GDKEYCI  FWPLEWT 


    See TXNRD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001166984.1  NP_443115.1  

    ENSEMBL proteins: 
     ENSP00000427753   ENSP00000430031   ENSP00000430605   ENSP00000429584  

    TXNRD3 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online peptides for TXNRD3

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    antibodies-online antibodies for TXNRD3 (15 products) 

    TXNRD3 Assay Products:

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    antibodies-online kits for TXNRD3 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR013027 FAD_pyr_nucl-diS_OxRdtase
     IPR002109 Glutaredoxin
     IPR012336 Thioredoxin-like_fold
     IPR012999 Pyr_OxRdtase_I_AS
     IPR004099 Pyr_nucl-diS_OxRdtase_dimer

    Graphical View of Domain Structure for InterPro Entry Q86VQ6

    ProtoNet protein and cluster: Q86VQ6

    4 Blocks protein domains:
    IPB001100 Pyridine nucleotide-disulphide oxidoreductase
    IPB001327 Pyridine nucleotide-disulphide oxidoreductase
    IPB002109 Glutaredoxin
    IPB013027 FAD-dependent pyridine nucleotide reductase signature


    UniProtKB/Swiss-Prot: TRXR3_HUMAN, Q86VQ6
    Domain: The N-terminal glutaredoxin domain does not contain the C-X-X-C redox-active motif normally found in
    glutaredoxins but activity may be mediated through a single cysteine. The C-terminal Cys-Sec motif of one subunit
    of the homodimer may transfer electrons from the thiol-disulfide center to the glutaredoxin domain of the other
    subunit (By similarity)
    Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
    Similarity: Contains 1 glutaredoxin domain


    Find genes that share domains with TXNRD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRXR3_HUMAN, Q86VQ6
    Function: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide
    bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role
    in sperm maturation by promoting formation of sperm structural components (By similarity)
    Catalytic activity: Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH

         Enzyme Numbers (IUBMB): EC 1.8.1.91 2 EC 1.8.12

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004791thioredoxin-disulfide reductase activity NAS10455115
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016668oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor ----
         
    Find genes that share ontologies with TXNRD3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TXNRD3

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TXNRD3 (see all 11):
    hsa-miR-15a hsa-miR-497 hsa-miR-1297 hsa-miR-214 hsa-miR-424 hsa-miR-26a hsa-miR-16 hsa-miR-195
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Addgene plasmids for TXNRD3 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRXR3_HUMAN, Q86VQ6: Cytoplasm (By similarity). Nucleus (By similarity). Microsome (By similarity). Endoplasmic
    reticulum (By similarity). Note=Detected in cytoplasm and nucleus in late spermatids (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    mitochondrion2
    nucleus2
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IEA--

    Find genes that share ontologies with TXNRD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TXNRD3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Selenium Pathway
    Selenium Pathway
    thioredoxin pathway0.00
    2PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    3Purine metabolism (KEGG)
    Pyrimidine metabolism0.38
    4Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    Mechanisms of CFTR activation by S nitrosoglutathione normal and CF 0.37
    5Selenocompound metabolism
    Selenocompound metabolism


    Find genes that share SuperPaths with TXNRD3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TXNRD3
        Antioxidant Action of Vitamin-C

    1 GeneGo (Thomson Reuters) Pathway for TXNRD3
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

    3 BioSystems Pathways for TXNRD3
        Selenium Metabolism and Selenoproteins
    Selenium Pathway
    thioredoxin pathway


    2 Kegg Pathways  (Kegg details for TXNRD3):
        Pyrimidine metabolism
    Selenocompound metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TXNRD3
    Interactions:

        Search GeneGlobe Interaction Network for TXNRD3

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process ----
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--
    GO:0045454cell redox homeostasis NAS10455115

    Find genes that share ontologies with TXNRD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TXNRD3 (TRXR3)

    5 HMDB Compounds for TXNRD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--

    1 Novoseek inferred chemical compound relationship for TXNRD3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxygen 0 1 17346242 (1)



    Find genes that share compounds with TXNRD3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TXNRD3 gene (2 alternative transcripts): 
    NM_001173513.1  NM_052883.1  

    Unigene Cluster for TXNRD3:

    Thioredoxin reductase 3
    Hs.477475  [show with all ESTs]
    Unigene Representative Sequence: NM_052883
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519162(uc003ejc.3) ENST00000524230(uc003ejd.2 uc011bkl.2)
    ENST00000518740 ENST00000523403
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TXNRD3 (see all 11):
    hsa-miR-15a hsa-miR-497 hsa-miR-1297 hsa-miR-214 hsa-miR-424 hsa-miR-26a hsa-miR-16 hsa-miR-195
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    Additional mRNA sequence: 

    AB113648.1 AF133519.1 AF171055.1 AK299502.1 BC030028.2 BC050032.1 BC130546.1 BC130548.1 

    2 DOTS entries:

    DT.410849  DT.100811876 

    Selected AceView cDNA sequences (see all 87):

    BQ929894 AI122818 AI631389 BF513089 CB107960 BC030028 AI656342 BU615686 
    AI363409 BQ478243 AF171055 AF133519 AW302269 AW194767 AA460642 BU685966 
    AB113648 AI277926 CB992975 BX348754 AA701430 AA910017 CB215836 BX102991 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TXNRD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCTGCTC
    TXNRD3 Expression
    About this image

    TXNRD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TXNRD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477475
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TXNRD3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txnrd31 , 5 thioredoxin reductase 31, 5 82.68(n)1
    86.7(a)1
      6 (40.01 cM)5
    2322231  NM_001178058.11  NP_001171529.11 
     896439885 
    chicken
    (Gallus gallus)
    Aves TXNRD31 thioredoxin reductase 3 75.38(n)
    76.91(a)
      416031  NM_001122777.1  NP_001116249.1 
    lizard
    (Anolis carolinensis)
    Reptilia TXNRD36
    thioredoxin reductase 3
    73(a)
    1 ↔ 1
    2(168581242-168623467)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ736127.12   -- 74.8(n)    BQ736127.1 
    zebrafish
    (Danio rerio)
    Actinopterygii txnrd11 thioredoxin reductase 1 67.17(n)
    72.12(a)
      352924  NM_183072.1  NP_898895.2 
    worm
    (Caenorhabditis elegans)
    Secernentea trxr-11 trxr-1 56.55(n)
    52.63(a)
      177466  NM_068684.6  NP_501085.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLR16
    Cytosolic and mitochondrial glutathione oxidoreduc...
    32(a)
    1 → many
    XVI(375502-376953) YPL091W


    ENSEMBL Gene Tree for TXNRD3 (if available)
    TreeFam Gene Tree for TXNRD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TXNRD3 gene
    TXNRD12  TXNRD22  GSR2  
    6 SIMAP similar genes for TXNRD3 using alignment to 5 protein entries:     TRXR3_HUMAN (see all proteins):
    TXNRD1    DKFZp781E0833    TXNRD2    GLRX    GLRX2    GSR

    Find genes that share paralogs with TXNRD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TXNRD3 (see all 749)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs729711781,2
    C--126329484(+) TTTCAC/AAGATC 2 -- int14Minor allele frequency- A:0.10WA NA EA 360
    rs1490641611,2
    --126329619(+) GCCTCA/TGTGAC 2 -- int10--------
    rs1420477691,2
    --126329705(+) CAGTCC/TCAGCT 2 -- int10--------
    rs1891363491,2
    --126329784(+) AGATCC/TCGTCT 2 -- int10--------
    rs1466671341,2
    C--126329857(+) CATTTA/TGGCTT 2 -- int10--------
    rs1924421901,2
    C--126329885(+) ATGGTA/CGAATT 4 D Y mis10--------
    rs1403741931,2
    --126330224(+) CAAAAC/TTCAGT 2 -- int10--------
    rs7772401,2
    C,F,H--126330242(-) CTCTAT/CACATG 2 -- int111Minor allele frequency- C:0.13NS EA NA WA 786
    rs1846562761,2
    C--126330275(+) ACTAGA/GCACAG 2 -- int10--------
    rs1455479541,2
    --126330349(+) AGGCTC/TACATT 2 -- int10--------

    HapMap Linkage Disequilibrium report for TXNRD3 (126290622 - 126373998 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TXNRD3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2005941CNV Deletion18987734
    esv2725874CNV Deletion23290073
    esv987942CNV Deletion20482838
    esv1465418CNV Deletion17803354
    esv2759CNV Deletion18987735
    esv987935CNV Deletion20482838
    esv2585777CNV Deletion19546169
    esv7947CNV Loss19470904
    nsv525296CNV Loss19592680
    dgv126n6CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606235    OMIM disorders: --


    Find genes that share disorders with TXNRD3           About GenesLikeMe

    Genetic Association Database (GAD): TXNRD3
    Human Genome Epidemiology (HuGE) Navigator: TXNRD3 (2 documents)

    Export disorders for TXNRD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TXNRD3 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with TXNRD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. (PubMed id 10455115)1, 2, 3, 9 Sun Q.-A....Gladyshev V.N. (J. Biol. Chem. 1999)
    2. CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes. (PubMed id 20018845)1, 2 Gerashchenko M.V.... Gladyshev V.N. (J. Biol. Chem. 2010)
    3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium. (PubMed id 22683372)1 Kipp A.P....Brigelius-FlohAc R. (Biochim. Biophys. Acta 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114112 HGNC: 20667 AceView: TXNRD3 Ensembl:ENSG00000197763 euGenes: HUgn114112
    ECgene: TXNRD3 Kegg: 114112 H-InvDB: TXNRD3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TXNRD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TXNRD3 gene:
    Search GeneIP for patents involving TXNRD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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