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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TXNRD3 Gene

protein-coding GIFtS: 49
GCID: GC03M126292

thioredoxin reductase 3

Explore 8 diseases affiliated with
TXNRD3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Thioredoxin Reductase 3¹ ²		Thioredoxin Reductase TR2² ³
TRXR3¹ ² ³ ⁵		EC 1.8.1.9³ ⁸
TGR¹ ² ³		Thioredoxin Glutathione Reductase²
TR2¹ ² ⁵		Thioredoxin Reductase 2²
Thioredoxin And Glutathione Reductase² ³		EC 1.8.1⁸

External Ids:	HGNC: 20667¹	Entrez Gene: 114112²	Ensembl: ENSG00000197763⁷	OMIM: 606235⁵	UniProtKB: Q86VQ6³

Export aliases for TXNRD3 gene to outside databases

Previous GC identifers: GC03M127607 GC03M127646 GC03M127808 GC03U901368 GC03M126327 GC03M123706

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TXNRD3:

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the reduction

of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine (Sec) residue

(which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal position. The 3'

UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary

for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants

encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: TRXR3_HUMAN, Q86VQ6

Function: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond

isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm

maturation by promoting formation of sperm structural components (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for TXNRD3
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TXNRD3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNRD3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3p13-q13.33

TXNRD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNRD3 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M126292: view genomic region (about GC identifiers)

Start:	126,290,622 bp from pter	End:	126,373,998 bp from pter
Size:	83,377 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRXR3_HUMAN, Q86VQ6 (See protein sequence)

Recommended Name: Thioredoxin reductase 3

Size: 682 amino acids; 74823 Da

Cofactor: Binds 1 FAD per subunit (By similarity)

Subunit: Homodimer (By similarity)

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Microsome (By similarity). Endoplasmic

reticulum (By similarity). Note=Detected in cytoplasm and nucleus in late spermatids (By similarity)

Miscellaneous: The thioredoxin reductase active site is a redox-active disulfide bond. The selenocysteine residue is

also essential for catalytic activity (By similarity)

Sequence caution: Sequence=AAH30028.1; Type=Erroneous termination; Positions=681; Note=Translated as Sec;

Sequence=AAH50032.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH50032.1;

Type=Erroneous termination; Positions=681; Note=Translated as Sec;

1 PDB 3D structure from and Proteopedia for TXNRD3:

3H8Q (3D)

Secondary accessions: Q6PIS8 Q9NNW6 Q9P101

Explore the universe of human proteins at neXtProt for TXNRD3: NX_Q86VQ6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86VQ6

4/13 DME Specific Peptides for TXNRD3 (Q86VQ6) (see all 13)

IGGGSGG

LGPNAGE

GDKEYCI

FWPLEWT

TXNRD3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001166984.1 NP_443115.1

ENSEMBL proteins:

ENSP00000427753 ENSP00000430031 ENSP00000430605 ENSP00000429584

Human Recombinant Protein Products for TXNRD3:

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	Uscn Proteins for TXNRD3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--

TXNRD3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TXNRD3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TXNRD3 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR013027 FAD_pyr_nucl-diS_OxRdtase

IPR002109 Glutaredoxin

IPR012999 Pyr_OxRdtase_I_AS

IPR004099 Pyr_nucl-diS_OxRdtase_dimer

IPR006338 Thioredoxin/glutathione_Rdtase

Graphical View of Domain Structure for InterPro Entry Q86VQ6

ProtoNet protein and cluster: Q86VQ6

4 Blocks protein families:

IPB001100 Pyridine nucleotide-disulphide oxidoreductase

IPB001327 Pyridine nucleotide-disulphide oxidoreductase

IPB002109 Glutaredoxin

IPB013027 FAD-dependent pyridine nucleotide reductase signature

UniProtKB/Swiss-Prot: TRXR3_HUMAN, Q86VQ6

Domain: The N-terminal glutaredoxin domain does not contain the C-X-X-C redox-active motif normally found in

glutaredoxins but activity may be mediated through a single cysteine. The C-terminal Cys-Sec motif of one subunit of

the homodimer may transfer electrons from the thiol-disulfide center to the glutaredoxin domain of the other subunit

(By similarity)

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family

Similarity: Contains 1 glutaredoxin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TRXR3_HUMAN, Q86VQ6

Function: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond

isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm

maturation by promoting formation of sperm structural components (By similarity)

Catalytic activity: Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH

Enzyme Numbers (IUBMB): EC 1.8.1.9¹ ² EC 1.8.1²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004791	thioredoxin-disulfide reductase activity	NAS	10455115
GO:0009055	electron carrier activity	IEA	--
GO:0015035	protein disulfide oxidoreductase activity	IEA	--
GO:0050660	flavin adenine dinucleotide binding	IEA	--
GO:0050661	NADP binding	IEA	--

TXNRD3 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TXNRD3

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNRD3
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		hsa-miR-15a hsa-miR-497 hsa-miR-1297 hsa-miR-214 hsa-miR-424 hsa-miR-26a hsa-miR-16 hsa-miR-195

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNRD3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

1.00

Selenium Metabolism and Selenoproteins

Selenium Metabolism and Selenoproteins

1.00

Selenium Pathway

Selenium Pathway

1.00

thioredoxin pathway

thioredoxin pathway

1.00

Selenocompound metabolism

Selenocompound metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TXNRD3

Antioxidant Action of Vitamin-C

1 GeneGo (Thomson Reuters) Pathway for TXNRD3

Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

3 BioSystems Pathways for TXNRD3

	Selenium Metabolism and Selenoproteins
	Selenium Pathway
	thioredoxin pathway

2 Kegg Pathways (Kegg details for TXNRD3):

	Pyrimidine metabolism
	Selenocompound metabolism

TXNRD3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TXNRD3

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	IEA	--
GO:0007283	spermatogenesis	IEA	--
GO:0022900	electron transport chain	IEA	--
GO:0030154	cell differentiation	IEA	--
GO:0045454	cell redox homeostasis	NAS	10455115

TXNRD3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TXNRD3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TXNRD3

5 HMDB Compounds for TXNRD3 About this table

Compound	Synonyms	CAS #	PubMed Ids
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Selenium	selenium (see all 5)	7782-49-2	--
Selenocysteine	(2R)-2-amino-3-selanylpropanoate (see all 8)	3614-08-2	--

1 Novoseek chemical compound relationship for TXNRD3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
oxygen	0	1	17346242 (1)

Search CenterWatch for drugs/clinical trials and news about TXNRD3 / TRXR3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TXNRD3 gene (2 alternative transcripts):

NM_001173513.1 NM_052883.1

Unigene Cluster for TXNRD3:

Thioredoxin reductase 3

Hs.477475 [show with all ESTs]

Unigene Representative Sequence: NM_052883

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000519162(uc003ejc.3) ENST00000524230(uc003ejd.2 uc011bkl.2)

ENST00000518740 ENST00000523403

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNRD3
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		hsa-miR-15a hsa-miR-497 hsa-miR-1297 hsa-miR-214 hsa-miR-424 hsa-miR-26a hsa-miR-16 hsa-miR-195

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Additional cDNA sequence:

AB113648.1 AF133519.1 AF171055.1 AK299502.1 BC030028.2 BC050032.1 BC130546.1 BC130548.1

2 DOTS entries:

DT.410849 DT.100811876

24/87 AceView cDNA sequences (see all 87):

AI122818 BF513089 BQ929894 AW302269 AF171055 CB992975 AB113648 AA701430

AF133519 BU685966 BC030028 AI363409 CB107960 AI277926 AI656342 AW194767

BU615686 AA460642 BX348754 AI631389 BQ478243 BE504826 AA311916 R07744

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TXNRD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGCTGCTC

About this image

TXNRD3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Cranial Neural Crest Cells

Neural Crest

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TXNRD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TXNRD3

SOURCE GeneReport for Unigene cluster: Hs.477475

SABiosciences Custom PCR Arrays for TXNRD3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for TXNRD3 gene from 9/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TXNRD3¹	thioredoxin reductase 3	75.72(n) 77.66(a)		416031 NM_001122777.1 NP_001116249.1
lizard (Anolis carolinensis)	Reptilia	TXNRD3⁶	--	76(a)	1 ↔ 1	2(168601611-168622037)
African clawed frog (Xenopus laevis)	Amphibia	BQ736127.1²	--	74.8(n)		BQ736127.1
zebrafish (Danio rerio)	Actinopterygii	txnrd1¹	thioredoxin reductase 1	67.17(n) 72.12(a)		352924 NM_183072.1 NP_898895.2
honey bee (Apis mellifera)	Insecta	--	--	34(a)	possible ortholog	GroupUn.1655(9-419)
worm (Caenorhabditis elegans)	Secernentea	trxr-1⁶ trxr-2⁶	Probable glutathione reductase 2	45(a) 44(a)	1 ↔ many possible ortholog	IV(7011992-7016569) III(8913648-8916668)
thale cress (Arabidopsis thaliana)	eudicotyledons	GR¹	glutathione reductase	48.43(n) 37.86(a)		824631 NM_115323.3 NP_191026.1
rice (Oryza sativa)	Liliopsida	Os03g0163300¹	hypothetical protein	48.53(n) 38.5(a)		4331719 NM_001055592.1 NP_001049057.1
E. coli (Escherichia coli)	Gamma proteobacteria	ykgC⁶	predicted pyridine nucleotide-disulfide oxidoreduc...	22(a)	possible ortholog	Chromosome(317900-319225)

ENSEMBL Gene Tree for TXNRD3 (if available)
TreeFam Gene Tree for TXNRD3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TXNRD3 gene

TXNRD1² TXNRD2² GSR²

6 SIMAP similar genes for TXNRD3 using alignment to 5 protein entries: TRXR3_HUMAN (see all proteins):

TXNRD1 DKFZp781E0833 TXNRD2 GLRX GLRX2 GSR

TXNRD3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150813312^1,2		--	126325422(+)	`ATTAAC/TAACAT`	3	--	ds500¹ int¹		0	--	--	--	--
rs139247962^1,2		--	126325813(+)	`TCCAAA/GAGGAC`	3	--	ds500¹ int¹		0	--	--	--	--
rs181202874^1,2		--	126325906(+)	`ATTCAC/TTTATG`	3	--	int¹ ut3¹		0	--	--	--	--
rs149994975^1,2		--	126326014(+)	`ACTATC/TAAGAT`	3	--	int¹ ut3¹		0	--	--	--	--
rs145394225^1,2		--	126326067(+)	`TATTTC/TGCTCA`	3	--	ut3¹ int¹		0	--	--	--	--
rs141056000^1,2		--	126326215(+)	`ACAGTA/GTGTAC`	3	--	ut3¹ int¹		0	--	--	--	--
rs112535698^1,2	C	--	126326289(+)	`CCAGTA/GAGCAT`	3	--	int¹ ut3¹		0	--	--	--	--
rs147935699^1,2		--	126326296(+)	`GCATGC/TGTGAA`	3	--	int¹ ut3¹		0	--	--	--	--
rs113449510^1,2		--	126326401(+)	`AATAGG/CGACCA`	3	--	int¹ ut3¹		1		CSA	2
rs143493675^1,2		--	126326439(+)	`ACTCAA/GAGGTC`	3	--	ut3¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TXNRD3 (126290622 - 126373998 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TXNRD3: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TXNRD3 for disorders           About GeneDecksing

OMIM gene information: 606235    OMIM disorders: --

8 diseases for TXNRD3:    About MalaCards

hepatocellular carcinoma pneumonia neuroblastoma tuberculosis

thyroiditis carcinoma malaria mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: TXNRD3 (2 documents)

Export disorders for TXNRD3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TXNRD3 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TXNRD3)

Utopia: connect your pdf to the dynamic
world of online information

Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. (PubMed id 10455115)^{1, 2, 3, 9} Sun Q.-A....Gladyshev V.N. (1999)
CUG start codon generates thioredoxin/glutathione red uctase isoforms in mouse testes. (PubMed id 20018845)¹ Gerashchenko M.V....Gladyshev V.N. (2010)
Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)¹ Starr J.M....Deary I.J. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)¹ Harris S.E....Deary I.J. (2007)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Characterization of mammalian selenoproteomes. (PubMed id 12775843)¹ Kryukov G.V.... Gladyshev V.N. (2003)
Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas. (PubMed id 12530083)³ Choi J.H....Kim J.R. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 114112	HGNC: 20667	AceView: TXNRD3	Ensembl:ENSG00000197763	euGenes: HUgn114112
ECgene: TXNRD3	Kegg: 114112	H-InvDB: TXNRD3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TXNRD3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TXNRD3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TXNRD3 gene:
Search GeneIP for patents involving TXNRD3

GeneCards and IP:
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thioredoxin reductase 3

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