Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TXNRD3 Gene

protein-coding   GIFtS: 49
GCID: GC03M126292

Thioredoxin Reductase 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thioredoxin Reductase 31 2     TGR2 3
TRXR32 3 5     EC 1.8.1.93 8
Thioredoxin Glutathione Reductase1 2     TR22 5
Thioredoxin And Glutathione Reductase2 3     Thioredoxin Reductase 22
Thioredoxin Reductase TR22 3     EC 1.8.18

External Ids:    HGNC: 206671   Entrez Gene: 1141122   Ensembl: ENSG000001977637   OMIM: 6062355   UniProtKB: Q86VQ63   

Export aliases for TXNRD3 gene to outside databases

Previous GC identifers: GC03M127607 GC03M127646 GC03M127808 GC03U901368 GC03M126327 GC03M123706


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TXNRD3 Gene:
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the
reduction of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine
(Sec) residue (which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal
position. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence
(SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively
spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Mar
2010)

GeneCards Summary for TXNRD3 Gene: 
TXNRD3 (thioredoxin reductase 3) is a protein-coding gene. Diseases associated with TXNRD3 include pneumonia, and neuroblastoma, and among its related super-pathways are PAK Pathway and Purine metabolism. GO annotations related to this gene include electron carrier activity and NADP binding. An important paralog of this gene is TXNRD1.

UniProtKB/Swiss-Prot: TRXR3_HUMAN, Q86VQ6
Function: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide
bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role
in sperm maturation by promoting formation of sperm structural components (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TXNRD3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TXNRD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNRD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3p13-q13.33

TXNRD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNRD3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M126292:  view genomic region     (about GC identifiers)

Start:
126,290,622 bp from pter      End:
126,373,998 bp from pter
Size:
83,377 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRXR3_HUMAN, Q86VQ6 (See protein sequence)
Recommended Name: Thioredoxin reductase 3  
Size: 643 amino acids; 70683 Da
Cofactor: Binds 1 FAD per subunit (By similarity)
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Microsome (By similarity). Endoplasmic
reticulum (By similarity). Note=Detected in cytoplasm and nucleus in late spermatids (By similarity)
Miscellaneous: The thioredoxin reductase active site is a redox-active disulfide bond. The selenocysteine residue
is also essential for catalytic activity (By similarity)
Caution: This sequence initiates at a CTG codon (PubMed:20018845)
Sequence caution: Sequence=AAH30028.1; Type=Erroneous termination; Positions=642; Note=Translated as Sec;
Sequence=AAH30028.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by
a non-canonical CTG leucine codon; Sequence=AAH50032.1; Type=Erroneous termination; Positions=642;
Note=Translated as Sec; Sequence=AAH50032.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The
initiator methionine is coded by a non-canonical CTG leucine codon;
1 PDB 3D structure from and Proteopedia for TXNRD3:
3H8Q (3D)    
Secondary accessions: Q6PIS8 Q9NNW6 Q9P101

Explore the universe of human proteins at neXtProt for TXNRD3: NX_Q86VQ6

Explore proteomics data for TXNRD3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86VQ6

  • 4/13 DME Specific Peptides for TXNRD3 (Q86VQ6) (see all 13)
     IGGGSGG  LGPNAGE  GDKEYCI  FWPLEWT 

    TXNRD3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TXNRD3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001166984.1  NP_443115.1  

    ENSEMBL proteins: 
     ENSP00000427753   ENSP00000430031   ENSP00000430605   ENSP00000429584  

    Human Recombinant Protein Products for TXNRD3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TXNRD3
    GenScript Custom Purified and Recombinant Proteins Services for TXNRD3
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IEA--

    TXNRD3 for ontologies           About GeneDecksing



    TXNRD3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TXNRD3
    GenScript Custom Superior Antibodies Services for TXNRD3
    Novus Biologicals TXNRD3 Antibody
    Abcam antibodies for TXNRD3
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for TXNRD3
    LSBio Antibodies in human, mouse, rat for TXNRD3 

    Assay Products for TXNRD3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TXNRD3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TXNRD3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/10 InterPro protein domains (see all 10):
     IPR013027 FAD_pyr_nucl-diS_OxRdtase
     IPR002109 Glutaredoxin
     IPR012999 Pyr_OxRdtase_I_AS
     IPR004099 Pyr_nucl-diS_OxRdtase_dimer
     IPR006338 Thioredoxin/glutathione_Rdtase

    Graphical View of Domain Structure for InterPro Entry Q86VQ6

    ProtoNet protein and cluster: Q86VQ6

    4 Blocks protein domains:
    IPB001100 Pyridine nucleotide-disulphide oxidoreductase
    IPB001327 Pyridine nucleotide-disulphide oxidoreductase
    IPB002109 Glutaredoxin
    IPB013027 FAD-dependent pyridine nucleotide reductase signature


    UniProtKB/Swiss-Prot: TRXR3_HUMAN, Q86VQ6
    Domain: The N-terminal glutaredoxin domain does not contain the C-X-X-C redox-active motif normally found in
    glutaredoxins but activity may be mediated through a single cysteine. The C-terminal Cys-Sec motif of one subunit
    of the homodimer may transfer electrons from the thiol-disulfide center to the glutaredoxin domain of the other
    subunit (By similarity)
    Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
    Similarity: Contains 1 glutaredoxin domain


    TXNRD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRXR3_HUMAN, Q86VQ6
    Function: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide
    bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role
    in sperm maturation by promoting formation of sperm structural components (By similarity)
    Catalytic activity: Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH

         Enzyme Numbers (IUBMB): EC 1.8.1.91 2 EC 1.8.12

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004791thioredoxin-disulfide reductase activity NAS10455115
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016668oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor ----
         
    TXNRD3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TXNRD3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TXNRD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TXNRD3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TXNRD3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNRD3
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNRD3 (see all 11):
    hsa-miR-15a hsa-miR-497 hsa-miR-1297 hsa-miR-214 hsa-miR-424 hsa-miR-26a hsa-miR-16 hsa-miR-195
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TXNRD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNRD3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TXNRD3
    Sirion Biotech Customized adenovirus for overexpression of TXNRD3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TXNRD3 (see all 11)
    OriGene ORF clones in mouse, rat for TXNRD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TXNRD3 (NM_052883)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNRD3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TXNRD3
    Sirion Biotech Customized lentivirus for stable overexpression of TXNRD3 
                         Customized lentivirus expression plasmids for stable overexpression of TXNRD3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TXNRD3
    Search LifeMap BioReagents cell lines for TXNRD3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNRD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TXNRD3 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    2Purine metabolism
    Pyrimidine metabolism0.38
    3CFTR folding and maturation (norm and CF)
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)0.37
    4thioredoxin pathway
    thioredoxin pathway
    5Selenium Pathway
    Selenium Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TXNRD3
        Antioxidant Action of Vitamin-C

    1 GeneGo (Thomson Reuters) Pathway for TXNRD3
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

    3 BioSystems Pathways for TXNRD3
        Selenium Metabolism and Selenoproteins
    Selenium Pathway
    thioredoxin pathway


    2         Kegg Pathways  (Kegg details for TXNRD3):
        Pyrimidine metabolism
    Selenocompound metabolism


    TXNRD3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TXNRD3

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--
    GO:0045454cell redox homeostasis NAS10455115
    GO:0055114oxidation-reduction process ----

    TXNRD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TXNRD3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TXNRD3 (TRXR3)

    5 HMDB Compounds for TXNRD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--

    1 Novoseek inferred chemical compound relationship for TXNRD3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxygen 0 1 17346242 (1)

    Search CenterWatch for drugs/clinical trials and news about TXNRD3 / TRXR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TXNRD3 gene (2 alternative transcripts): 
    NM_001173513.1  NM_052883.1  

    Unigene Cluster for TXNRD3:

    Thioredoxin reductase 3
    Hs.477475  [show with all ESTs]
    Unigene Representative Sequence: NM_052883
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519162(uc003ejc.3) ENST00000524230(uc003ejd.2 uc011bkl.2)
    ENST00000518740 ENST00000523403
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNRD3
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNRD3 (see all 11):
    hsa-miR-15a hsa-miR-497 hsa-miR-1297 hsa-miR-214 hsa-miR-424 hsa-miR-26a hsa-miR-16 hsa-miR-195
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TXNRD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNRD3
    Clone
    Products:
         
    OriGene clones in human, mouse for TXNRD3 (see all 11)
    OriGene ORF clones in mouse, rat for TXNRD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TXNRD3 (NM_052883)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNRD3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TXNRD3
    Sirion Biotech Customized lentivirus for stable overexpression of TXNRD3 
                         Customized lentivirus expression plasmids for stable overexpression of TXNRD3 
    Primer
    Products:
        
    Browse OriGene qPCR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXNRD3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNRD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNRD3

    Additional mRNA sequence: 

    AB113648.1 AF133519.1 AF171055.1 AK299502.1 BC030028.2 BC050032.1 BC130546.1 BC130548.1 

    2 DOTS entries:

    DT.410849  DT.100811876 

    24/87 AceView cDNA sequences (see all 87):

    AB113648 BU685966 CB992975 AF171055 AA701430 AW194767 AI122818 AF133519 
    BX348754 BQ478243 AW302269 AI656342 AI363409 BQ929894 BU615686 AA460642 
    BF513089 AI631389 AI277926 BC030028 CB107960 BI831792 BI520138 BX102991 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TXNRD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCTGCTC
    TXNRD3 Expression
    About this image


    See TXNRD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TXNRD3

    SOURCE GeneReport for Unigene cluster: Hs.477475
        SABiosciences Custom PCR Arrays for TXNRD3
    Primer
    Products:
    Browse OriGene qPCR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXNRD3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNRD3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNRD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNRD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TXNRD3 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txnrd31 , 5 thioredoxin reductase 31, 5 82.68(n)1
    86.7(a)1
      6 (40.01 cM)5
    2322231  NM_001178058.11  NP_001171529.11 
     896439885 
    chicken
    (Gallus gallus)
    Aves TXNRD31 thioredoxin reductase 3 75.72(n)
    77.66(a)
      416031  NM_001122777.1  NP_001116249.1 
    lizard
    (Anolis carolinensis)
    Reptilia TXNRD36
    thioredoxin reductase 3
    72(a)
    1 ↔ 1
    2(168581242-168623467)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ736127.12   -- 74.8(n)    BQ736127.1 
    zebrafish
    (Danio rerio)
    Actinopterygii txnrd11 thioredoxin reductase 1 67.17(n)
    72.12(a)
      352924  NM_183072.1  NP_898895.2 
    worm
    (Caenorhabditis elegans)
    Secernentea trxr-16
    trxr-26
    Probable glutathione reductase 2
    45(a)
    44(a)
    1 ↔ many
    possible ortholog
    IV(7012003-7016580)
    III(8913727-8916746)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLR16
    Cytosolic and mitochondrial glutathione oxidoreduc...
    31(a)
    1 → many
    XVI(375502-376953)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GR1 glutathione reductase 48.43(n)
    37.86(a)
      824631  NM_115323.3  NP_191026.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01633001 hypothetical protein 48.53(n)
    38.5(a)
      4331719  NM_001055592.1  NP_001049057.1 


    ENSEMBL Gene Tree for TXNRD3 (if available)
    TreeFam Gene Tree for TXNRD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TXNRD3 gene
    TXNRD12  TXNRD22  GSR2  
    6 SIMAP similar genes for TXNRD3 using alignment to 5 protein entries:     TRXR3_HUMAN (see all proteins):
    TXNRD1    DKFZp781E0833    TXNRD2    GLRX    GLRX2    GSR

    TXNRD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/749 SNPs in TXNRD3 are shown (see all 749)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs729711781,2
    C--126329484(+) TTTCAC/AAGATC 2 -- int14Minor allele frequency- A:0.10WA NA EA 360
    rs1490641611,2
    --126329619(+) GCCTCA/TGTGAC 2 -- int10--------
    rs1420477691,2
    --126329705(+) CAGTCC/TCAGCT 2 -- int10--------
    rs1891363491,2
    --126329784(+) AGATCC/TCGTCT 2 -- int10--------
    rs1466671341,2
    C--126329857(+) CATTTA/TGGCTT 2 -- int10--------
    rs1924421901,2
    C--126329885(+) ATGGTA/CGAATT 4 D Y mis10--------
    rs1403741931,2
    --126330224(+) CAAAAC/TTCAGT 2 -- int10--------
    rs7772401,2
    C,F,H--126330242(-) CTCTAT/CACATG 2 -- int111Minor allele frequency- C:0.13NS EA NA WA 786
    rs1846562761,2
    C--126330275(+) ACTAGA/GCACAG 2 -- int10--------
    rs1455479541,2
    --126330349(+) AGGCTC/TACATT 2 -- int10--------

    HapMap Linkage Disequilibrium report for TXNRD3 (126290622 - 126373998 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for TXNRD3 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2005941CNV Deletion18987734
    esv2725874CNV Deletion23290073
    esv987942CNV Deletion20482838
    esv1465418CNV Deletion17803354
    esv2759CNV Deletion18987735
    esv987935CNV Deletion20482838
    esv2585777CNV Deletion19546169
    esv7947CNV Loss19470904
    nsv525296CNV Loss19592680
    dgv126n6CNV Loss16902084

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TXNRD3
    DNA2.0 Custom Variant and Variant Library Synthesis for TXNRD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606235    OMIM disorders: --

    5 diseases for TXNRD3:    About MalaCards
    pneumonia    neuroblastoma    tuberculosis    hepatocellular carcinoma
    thyroiditis


    TXNRD3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TXNRD3
    Human Genome Epidemiology (HuGE) Navigator: TXNRD3 (2 documents)

    Export disorders for TXNRD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TXNRD3 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with TXNRD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. (PubMed id 10455115)1, 2, 3, 9 Sun Q.-A....Gladyshev V.N. (1999)
    2. CUG start codon generates thioredoxin/glutathione red uctase isoforms in mouse testes. (PubMed id 20018845)1, 2 Gerashchenko M.V....Gladyshev V.N. (2010)
    3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium. (PubMed id 22683372)1 Kipp A.P....Brigelius-Flohe R. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114112 HGNC: 20667 AceView: TXNRD3 Ensembl:ENSG00000197763 euGenes: HUgn114112
    ECgene: TXNRD3 Kegg: 114112 H-InvDB: TXNRD3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TXNRD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TXNRD3 gene:
    Search GeneIP for patents involving TXNRD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TXNRD3  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TXNRD3  
     Browse OriGene qSTAR qPCR primer pairs   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TXNRD3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TXNRD3   OriGene Custom Protein Services for TXNRD3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TXNRD3
     QIAGEN SeqTarget long-range PCR primers for resequencing TXNRD3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNRD3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNRD3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNRD3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNRD3
     GenScript Custom Purified and Recombinant Proteins Services for TXNRD3 GenScript cDNA clones with any tag delivered in your preferred vector for TXNRD3
     GenScript Custom Assay Services for TXNRD3 GenScript Custom Superior Antibodies Services for TXNRD3
     GenScript Custom overexpressing Cell Line Services for TXNRD3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for TXNRD3
     Search Chromatin IP Primers for TXNRD3
     RT2 qPCR Primer Assay in human, mouse, rat TXNRD3
     Search GNC Networks for TXNRD3
     SABiosciences PCR Arrays including human, mouse, rat TXNRD3
     Search Tocris compounds for TXNRD3 (TRXR3)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TXNRD3 antibodies
     Antibodies for TXNRD3
     See all of Abcam's Antibodies, Kits and Proteins for TXNRD3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for TXNRD3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNRD3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TXNRD3
     Browse SwitchGear Promoter luciferase reporter plasmids for TXNRD3
     Search ThermoFisher Antibodies for TXNRD3
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TXNRD3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TXNRD3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TXNRD3
    Customized:
     lentivirus for stable overexpression of TXNRD3
     lentivirus expression plasmids for stable overexpression of TXNRD3
     adenovirus for overexpression of TXNRD3
     LSBio Antibodies in human, mouse, rat for TXNRD3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TXNRD3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4