Aliases for TXNRD3 Gene
External Ids for TXNRD3 Gene
Previous GeneCards Identifiers for TXNRD3 Gene
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine (Sec) residue (which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal position. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
GeneCards Summary for TXNRD3 Gene
TXNRD3 (Thioredoxin Reductase 3) is a Protein Coding gene. Diseases associated with TXNRD3 include parasitic helminthiasis infectious disease. Among its related pathways are Pyrimidine metabolism (KEGG) and Selenocompound metabolism. GO annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding. An important paralog of this gene is TXNRD2.
UniProtKB/Swiss-Prot for TXNRD3 Gene
Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity).