Aliases for TXNRD2 Gene
External Ids for TXNRD2 Gene
Previous GeneCards Identifiers for TXNRD2 Gene
This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
GeneCards Summary for TXNRD2 Gene
TXNRD2 (Thioredoxin Reductase 2) is a Protein Coding gene. Diseases associated with TXNRD2 include Familial Glucocorticoid Deficiency and Familial Isolated Dilated Cardiomyopathy. Among its related pathways are Selenium Metabolism and Selenoproteins and Purine metabolism (KEGG). GO annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is TXNRD1.
UniProtKB/Swiss-Prot for TXNRD2 Gene
Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.