Aliases for TXNRD2 Gene
External Ids for TXNRD2 Gene
Previous GeneCards Identifiers for TXNRD2 Gene
This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
GeneCards Summary for TXNRD2 Gene
TXNRD2 (Thioredoxin Reductase 2) is a Protein Coding gene. Diseases associated with TXNRD2 include Thyroid Hormone Resistance and Familial Glucocorticoid Deficiency. Among its related pathways are Glucose / Energy Metabolism and Selenocompound metabolism. GO annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is TXNRD3.
UniProtKB/Swiss-Prot for TXNRD2 Gene
Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.