Aliases for TXNRD1 Gene
External Ids for TXNRD1 Gene
Previous GeneCards Identifiers for TXNRD1 Gene
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for TXNRD1 Gene
TXNRD1 (Thioredoxin Reductase 1) is a Protein Coding gene. Among its related pathways are PAK Pathway and Metabolism. GO annotations related to this gene include protein homodimerization activity and flavin adenine dinucleotide binding. An important paralog of this gene is TXNRD3.
UniProtKB/Swiss-Prot for TXNRD1 Gene
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.