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TXNL4B Gene

protein-coding   GIFtS: 48
GCID: GC16M072118

Thioredoxin-Like 4B

  Search for TXNL4B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin-Like 4B1 2
DLP2 3
Dim1-Like Protein2 3
Dim22
Thioredoxin-Like Protein 4B2
DIM23

External Ids:    HGNC: 260411   Entrez Gene: 549572   Ensembl: ENSG000001408307   UniProtKB: Q9NX013   

Export aliases for TXNL4B gene to outside databases

Previous GC identifers: GC16M070677 GC16M057885


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TXNL4B Gene:
TXNL4B (thioredoxin-like 4B) is a protein-coding gene. An important paralog of this gene is TXNL4A.

UniProtKB/Swiss-Prot: TXN4B_HUMAN, Q9NX01
Function: Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition

Gene Wiki entry for TXNL4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TXNL4B gene promoter:
         p53   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXNL4B promoter sequence
   Search Chromatin IP Primers for TXNL4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXNL4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.2   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22.2

TXNL4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNL4B gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M072118:  view genomic region     (about GC identifiers)

Start:
72,078,188 bp from pter      End:
72,128,330 bp from pter
Size:
50,143 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TXN4B_HUMAN, Q9NX01 (See protein sequence)
Recommended Name: Thioredoxin-like protein 4B  
Size: 149 amino acids; 17015 Da
Subunit: Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome
3 PDB 3D structures from and Proteopedia for TXNL4B:
1XBS (3D)        3GIX (3D)        4IN0 (3D)    
Secondary accessions: D3DWS6

Explore the universe of human proteins at neXtProt for TXNL4B: NX_Q9NX01

Explore proteomics data for TXNL4B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TXNL4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135789.1  NP_001135790.1  NP_060323.1  

    ENSEMBL proteins: 
     ENSP00000454635   ENSP00000268483   ENSP00000392310   ENSP00000455550   ENSP00000457699  
     ENSP00000408130  

    TXNL4B Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for TXNL4B
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TXNL4B
    Cloud-Clone Corp. Proteins for TXNL4B

     
    Search eBioscience for Proteins for TXNL4B 

    TXNL4B Antibody Products:

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    TXNL4B Assay Products:

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    Cloud-Clone Corp. ELISAs for TXNL4B
    Cloud-Clone Corp. CLIAs for TXNL4B
    Search eBioscience for ELISAs for TXNL4B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR004123 mRNA_splic_U5

    Graphical View of Domain Structure for InterPro Entry Q9NX01

    ProtoNet protein and cluster: Q9NX01

    1 Blocks protein domain: IPB004123 Pre-mRNA splicing protein

    UniProtKB/Swiss-Prot: TXN4B_HUMAN, Q9NX01
    Similarity: Belongs to the DIM1 family


    Find genes that share domains with TXNL4B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXN4B_HUMAN, Q9NX01
    Function: Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TXNL4B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TXNL4B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TXNL4B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TXNL4B

    miRNA
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    Block miRNA regulation of human, mouse, rat TXNL4B using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TXNL4B:
    hsa-miR-576-3p hsa-miR-4254 hsa-miR-2110 hsa-miR-508-5p hsa-miR-1207-3p hsa-miR-1193 hsa-miR-3921 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidTXNL4B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TXNL4B
    Predesigned siRNA for gene silencing in human, mouse, rat TXNL4B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TXNL4B

    Clone
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    OriGene clones in human, mouse for TXNL4B (see all 17)
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    GenScript: all cDNA clones in your preferred vector (see all 3): TXNL4B (NM_001142318)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNL4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNL4B
    Addgene plasmids for TXNL4B 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNL4B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TXN4B_HUMAN, Q9NX01: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005681spliceosomal complex IEA--

    Find genes that share ontologies with TXNL4B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including TXNL4B: 
              Necrosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TXNL4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TXNL4B (Q9NX013 ENSP000002684834) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF6O949063, ENSP000002660794I2D: score=2 STRING: ENSP00000266079
    AMPHENSP000003486024STRING: ENSP00000348602
    SART1ENSP000003104484STRING: ENSP00000310448
    SNRNP200ENSP000003171234STRING: ENSP00000317123
    SNRPD3ENSP000002158294STRING: ENSP00000215829
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0007067mitosis IEA--
    GO:0008380RNA splicing IEA--
    GO:0045454cell redox homeostasis ----

    Find genes that share ontologies with TXNL4B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TXNL4B (TXN4B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TXNL4B gene (3 alternative transcripts): 
    NM_001142317.1  NM_001142318.1  NM_017853.2  

    Unigene Cluster for TXNL4B:

    Thioredoxin-like 4B
    Hs.134406  [show with all ESTs]
    Unigene Representative Sequence: NM_017853
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562153 ENST00000268483(uc010cgl.2 uc002fca.3 uc010vmo.2)
    ENST00000426362 ENST00000565171 ENST00000569767 ENST00000423037(uc010vmn.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TXNL4B using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TXNL4B:
    hsa-miR-576-3p hsa-miR-4254 hsa-miR-2110 hsa-miR-508-5p hsa-miR-1207-3p hsa-miR-1193 hsa-miR-3921 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidTXNL4B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TXNL4B
    Predesigned siRNA for gene silencing in human, mouse, rat TXNL4B
    Clone
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    OriGene clones in human, mouse for TXNL4B (see all 17)
    OriGene ORF clones in mouse, rat for TXNL4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TXNL4B (NM_001142318)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNL4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNL4B
    Addgene plasmids for TXNL4B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TXNL4B
    OriGene qSTAR qPCR primer pairs in human, mouse for TXNL4B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TXNL4B
      QuantiTect SYBR Green Assays in human, mouse, rat TXNL4B
      QuantiFast Probe-based Assays in human, mouse, rat TXNL4B

    Additional mRNA sequence: 

    AK000518.1 AK222889.1 AK308891.1 AY566808.1 BC009646.1 CR457240.1 

    12 DOTS entries:

    DT.442091  DT.100758093  DT.120676175  DT.120676237  DT.91893224  DT.100743517  DT.120676186  DT.91871062 
    DT.95164976  DT.97841859  DT.100786705  DT.92028303 

    Selected AceView cDNA sequences (see all 125):

    BF593392 BF055190 AI052723 BU172712 BE409023 AA373245 BU631267 AY566808 
    BQ007095 BM700475 BM714705 F12366 BE463736 BC009646 AI279309 CD517462 
    CD628675 F15216 AI810585 AA904653 F09985 BP345992 BE018752 CR617379 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TXNL4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTCTGGAC
    TXNL4B Expression
    About this image


    TXNL4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
    TXNL4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TXNL4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.134406
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TXNL4B: 
              Necrosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TXNL4B
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    QuantiFast Probe-based Assays in human, mouse, rat TXNL4B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNL4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TXNL4B gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txnl4b1 , 5 thioredoxin-like 4B1, 5 87.92(n)1
    97.32(a)1
      8 (57.10 cM)5
    2347231  NM_175646.31  NP_783577.21 
     1095658925 
    chicken
    (Gallus gallus)
    Aves TXNL4B1 thioredoxin-like 4B 81.66(n)
    89.26(a)
      418396  NM_001278071.1  NP_001265000.1 
    lizard
    (Anolis carolinensis)
    Reptilia TXNL4B6
    thioredoxin-like 4B
    92(a)
    1 ↔ 1
    AAWZ02038071(8677-9498)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.70852 Xenopus laevis transcribed sequence with strong similarity more 81.39(n)    CA972134.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.144982 Transcribed sequence with moderate similarity to protein more 77.34(n)    57060579 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dim16
    Dim1
    35(a)
    1 → many
    2L(4403251-4403955)
    worm
    (Caenorhabditis elegans)
    Secernentea Y54G2A.756
    Protein Y54G2A.75 (Y54G2A.75) mRNA, complete cds
    37(a)
    1 → many
    IV(2890890-2891579) WBGene00235102
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIB16
    17-kDa component of the U4/U6aU5 tri-snRNP, plays ...
    33(a)
    1 → many
    XVI(704225-704656) YPR082C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G247301 AT3G24730 61.74(n)
    60.4(a)
      822071  NM_113385.2  NP_189117.2 
    rice
    (Oryza sativa)
    Liliopsida Os11g02979001 Os11g0297900 59.46(n)
    60.14(a)
      4350321  NM_001074259.1  NP_001067727.1 


    ENSEMBL Gene Tree for TXNL4B (if available)
    TreeFam Gene Tree for TXNL4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TXNL4B gene
    TXNL4A2  
    1 SIMAP similar gene for TXNL4B using alignment to 5 protein entries:     TXN4B_HUMAN (see all proteins):
    TXNL4A

    Find genes that share paralogs with TXNL4B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TXNL4B (see all 213)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs740298241,2
    C,F--72118280(+) GAAAGG/CTTCCT 3 -- int12Minor allele frequency- C:0.08WA 120
    rs99410871,2
    C,F,A,H--72118324(+) AAACCG/ACCTTG 3 -- int125Minor allele frequency- A:0.39NS EA NA WA 2494
    rs1930592241,2
    C--72118336(+) TCCAAA/TCCTTA 3 -- int10--------
    rs1430821301,2
    --72118391(+) GCATAA/GCCAAT 3 -- int10--------
    rs614040391,2
    C,F--72118418(+) TGTGCG/AGTCCA 3 -- int12Minor allele frequency- A:0.04NA EA 240
    rs1848495641,2
    --72118469(+) GTTAGC/GGTTAG 3 -- int10--------
    rs25508731,2
    C,H--72118491(+) CCTTTG/ATTAGG 3 -- int16Minor allele frequency- A:0.00NS EA NA 422
    rs1881090881,2
    C--72118522(+) AGGCGC/TGGGCA 3 -- int10--------
    rs1482365251,2
    --72118641(+) AGAAGA/TCATGA 3 -- int10--------
    rs1914474041,2
    --72118659(+) GCACAC/TGCAGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for TXNL4B (72078188 - 72128330 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TXNL4B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714683CNV Deletion23290073
    esv270717CNV Insertion20981092
    nsv833273CNV Loss17160897
    nsv428329CNV Gain18775914
    dgv898e1CNV Complex17122850
    nsv7285OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TXNL4B
    DNA2.0 Custom Variant and Variant Library Synthesis for TXNL4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TXNL4B gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TXNL4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression. (PubMed id 15161931)1, 2, 3 Sun X.... Shang Y. (J. Biol. Chem. 2004)
    2. Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2. (PubMed id 16142897)1, 2, 9 Simeoni F.... Divita G. (Biochemistry 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B. (PubMed id 16511018)1, 9 Jin T....Zhang Y.Z. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2005)
    6. High-resolution crystal structure of human Dim2/TXNL4B. (PubMed id 23519793)1 Jin T....Zhang Y. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2013)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    9. A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export. (PubMed id 21048991)1 Wild T....Kutay U. (PLoS Biol. 2010)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54957 HGNC: 26041 AceView: TXNL4B Ensembl:ENSG00000140830 euGenes: HUgn54957
    ECgene: TXNL4B H-InvDB: TXNL4B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TXNL4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TXNL4B gene:
    Search GeneIP for patents involving TXNL4B

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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