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Aliases for TXNL4B Gene

Aliases for TXNL4B Gene

  • Thioredoxin Like 4B 2 3 5
  • Dim1-Like Protein 3 4
  • Dim2 3 4
  • DLP 3 4
  • Thioredoxin-Like Protein 4B 3
  • Thioredoxin-Like 4B 2

External Ids for TXNL4B Gene

Previous GeneCards Identifiers for TXNL4B Gene

  • GC16M070677
  • GC16M057885

Summaries for TXNL4B Gene

GeneCards Summary for TXNL4B Gene

TXNL4B (Thioredoxin Like 4B) is a Protein Coding gene. An important paralog of this gene is TXNL4A.

UniProtKB/Swiss-Prot for TXNL4B Gene

  • Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.

Gene Wiki entry for TXNL4B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNL4B Gene

Genomics for TXNL4B Gene

Regulatory Elements for TXNL4B Gene

Enhancers for TXNL4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TXNL4B on UCSC Golden Path with GeneCards custom track

Promoters for TXNL4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TXNL4B on UCSC Golden Path with GeneCards custom track

Genomic Location for TXNL4B Gene

Chromosome:
16
Start:
72,044,289 bp from pter
End:
72,094,431 bp from pter
Size:
50,143 bases
Orientation:
Minus strand

Genomic View for TXNL4B Gene

Genes around TXNL4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNL4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNL4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNL4B Gene

Proteins for TXNL4B Gene

  • Protein details for TXNL4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX01-TXN4B_HUMAN
    Recommended name:
    Thioredoxin-like protein 4B
    Protein Accession:
    Q9NX01
    Secondary Accessions:
    • D3DWS6

    Protein attributes for TXNL4B Gene

    Size:
    149 amino acids
    Molecular mass:
    17015 Da
    Quaternary structure:
    • Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome.

    Three dimensional structures from OCA and Proteopedia for TXNL4B Gene

neXtProt entry for TXNL4B Gene

Post-translational modifications for TXNL4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TXNL4B Gene

Domains & Families for TXNL4B Gene

Protein Domains for TXNL4B Gene

Suggested Antigen Peptide Sequences for TXNL4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX01

UniProtKB/Swiss-Prot:

TXN4B_HUMAN :
  • Belongs to the DIM1 family.
Family:
  • Belongs to the DIM1 family.
genes like me logo Genes that share domains with TXNL4B: view

No data available for Gene Families for TXNL4B Gene

Function for TXNL4B Gene

Molecular function for TXNL4B Gene

UniProtKB/Swiss-Prot Function:
Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.

Gene Ontology (GO) - Molecular Function for TXNL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TXNL4B: view

Phenotypes for TXNL4B Gene

genes like me logo Genes that share phenotypes with TXNL4B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TXNL4B

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNL4B Gene

Localization for TXNL4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNL4B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXNL4B Gene COMPARTMENTS Subcellular localization image for TXNL4B gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for TXNL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 spliceosomal complex IBA --
GO:0005682 U5 snRNP IBA --
GO:0046540 U4/U6 x U5 tri-snRNP complex IBA --
genes like me logo Genes that share ontologies with TXNL4B: view

Pathways & Interactions for TXNL4B Gene

SuperPathways for TXNL4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly IBA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with TXNL4B: view

No data available for Pathways by source and SIGNOR curated interactions for TXNL4B Gene

Drugs & Compounds for TXNL4B Gene

No Compound Related Data Available

Transcripts for TXNL4B Gene

Unigene Clusters for TXNL4B Gene

Thioredoxin-like 4B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNL4B Gene

No ASD Table

Relevant External Links for TXNL4B Gene

GeneLoc Exon Structure for
TXNL4B
ECgene alternative splicing isoforms for
TXNL4B

Expression for TXNL4B Gene

mRNA expression in normal human tissues for TXNL4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TXNL4B Gene

This gene is overexpressed in Testis (20.1), Ovary (11.2), Salivary gland (8.3), Fetal testis (8.0), Stomach (7.3), and Esophagus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXNL4B Gene



NURSA nuclear receptor signaling pathways regulating expression of TXNL4B Gene:

TXNL4B

SOURCE GeneReport for Unigene cluster for TXNL4B Gene:

Hs.134406
genes like me logo Genes that share expression patterns with TXNL4B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TXNL4B Gene

Orthologs for TXNL4B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXNL4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TXNL4B 34
  • 92.39 (n)
  • 97.32 (a)
TXNL4B 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC612963 34
  • 93.51 (n)
  • 97.32 (a)
TXNL4B 35
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TXNL4B 34
  • 100 (n)
  • 100 (a)
TXNL4B 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Txnl4b 34
  • 88.81 (n)
  • 97.99 (a)
mouse
(Mus musculus)
Mammalia Txnl4b 16
Txnl4b 35
  • 97 (a)
OneToOne
Txnl4b 34
  • 87.92 (n)
  • 97.32 (a)
oppossum
(Monodelphis domestica)
Mammalia TXNL4B 35
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves TXNL4B 34
  • 81.66 (n)
  • 89.26 (a)
TXNL4B 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TXNL4B 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14990 34
txnl4b 34
  • 78.97 (n)
  • 87.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7085 34
zebrafish
(Danio rerio)
Actinopterygii Dr.14498 34
txnl4b 34
  • 77.4 (n)
  • 83.89 (a)
txnl4b 35
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dim1 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.75 35
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIB1 35
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G24730 34
  • 61.74 (n)
  • 60.4 (a)
rice
(Oryza sativa)
Liliopsida Os11g0297900 34
  • 59.46 (n)
  • 60.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9800 35
  • 36 (a)
OneToMany
Species where no ortholog for TXNL4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNL4B Gene

ENSEMBL:
Gene Tree for TXNL4B (if available)
TreeFam:
Gene Tree for TXNL4B (if available)

Paralogs for TXNL4B Gene

Paralogs for TXNL4B Gene

(1) SIMAP similar genes for TXNL4B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TXNL4B: view

Variants for TXNL4B Gene

Sequence variations from dbSNP and Humsavar for TXNL4B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3169362 -- 72,086,594(-) TCTTG(A/G)CACAG utr-variant-3-prime
rs3852781 -- 72,089,657(-) CACAT(A/G/T)ACATA intron-variant
rs8182209 -- 72,088,416(+) GGTAA(A/T)TGGAT intron-variant
rs152828 -- 72,089,987(-) TCATA(A/G)GCAGG intron-variant
rs9930890 -- 72,085,913(+) CAGGA(A/G)AATGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TXNL4B Gene

Variant ID Type Subtype PubMed ID
dgv3017n100 CNV gain 25217958
esv2714683 CNV deletion 23290073
esv2758654 CNV gain 17122850
esv3306441 CNV mobile element insertion 20981092
esv3441283 CNV insertion 20981092
nsv428329 CNV gain 18775914
nsv7285 OTHER inversion 18451855
nsv833273 CNV loss 17160897

Variation tolerance for TXNL4B Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNL4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNL4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNL4B Gene

Disorders for TXNL4B Gene

Relevant External Links for TXNL4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXNL4B

No disorders were found for TXNL4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNL4B Gene

Publications for TXNL4B Gene

  1. Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2. (PMID: 16142897) Simeoni F. … Divita G. (Biochemistry 2005) 3 4 22 65
  2. DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression. (PMID: 15161931) Sun X. … Shang Y. (J. Biol. Chem. 2004) 2 3 4 65
  3. Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B. (PMID: 16511018) Jin T. … Zhang Y.Z. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2005) 3 22 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for TXNL4B Gene

Sources for TXNL4B Gene

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