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Aliases for TXNL4B Gene

Aliases for TXNL4B Gene

  • Thioredoxin-Like 4B 2 3
  • Dim1-Like Protein 3 4
  • Dim2 3 4
  • DLP 3 4
  • Thioredoxin-Like Protein 4B 3

External Ids for TXNL4B Gene

Summaries for TXNL4B Gene

GeneCards Summary for TXNL4B Gene

TXNL4B (Thioredoxin-Like 4B) is a Protein Coding gene. An important paralog of this gene is TXNL4A.

UniProtKB/Swiss-Prot for TXNL4B Gene

  • Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.

Gene Wiki entry for TXNL4B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNL4B Gene

Genomics for TXNL4B Gene

Genomic Location for TXNL4B Gene

Start:
72,044,265 bp from pter
End:
72,094,431 bp from pter
Size:
50,167 bases
Orientation:
Minus strand

Genomic View for TXNL4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXNL4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNL4B Gene

Regulatory Elements for TXNL4B Gene

Proteins for TXNL4B Gene

  • Protein details for TXNL4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX01-TXN4B_HUMAN
    Recommended name:
    Thioredoxin-like protein 4B
    Protein Accession:
    Q9NX01
    Secondary Accessions:
    • D3DWS6

    Protein attributes for TXNL4B Gene

    Size:
    149 amino acids
    Molecular mass:
    17015 Da
    Quaternary structure:
    • Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome.

    Three dimensional structures from OCA and Proteopedia for TXNL4B Gene

neXtProt entry for TXNL4B Gene

Proteomics data for TXNL4B Gene at MOPED

Post-translational modifications for TXNL4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TXNL4B Gene

No data available for DME Specific Peptides for TXNL4B Gene

Domains for TXNL4B Gene

Protein Domains for TXNL4B Gene

UniProtKB/Swiss-Prot:

TXN4B_HUMAN
Family:
  • Belongs to the DIM1 family.:
    • Q9NX01
genes like me logo Genes that share domains with TXNL4B: view

No data available for Gene Families for TXNL4B Gene

Function for TXNL4B Gene

Molecular function for TXNL4B Gene

UniProtKB/Swiss-Prot Function: Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.

Gene Ontology (GO) - Molecular Function for TXNL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TXNL4B: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TXNL4B Gene

Localization for TXNL4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNL4B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXNL4B Gene COMPARTMENTS Subcellular localization image for TXNL4B gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TXNL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 spliceosomal complex IBA --
GO:0005682 U5 snRNP IBA --
GO:0046540 U4/U6 x U5 tri-snRNP complex IBA --
genes like me logo Genes that share ontologies with TXNL4B: view

Pathways for TXNL4B Gene

SuperPathways for TXNL4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly IBA --
GO:0006397 mRNA processing --
GO:0007067 mitotic nuclear division IEA --
GO:0008380 RNA splicing --
GO:0045454 cell redox homeostasis --
genes like me logo Genes that share ontologies with TXNL4B: view

No data available for Pathways by source for TXNL4B Gene

Transcripts for TXNL4B Gene

Unigene Clusters for TXNL4B Gene

Thioredoxin-like 4B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXNL4B Gene

No ASD Table

Relevant External Links for TXNL4B Gene

GeneLoc Exon Structure for
TXNL4B
ECgene alternative splicing isoforms for
TXNL4B

Expression for TXNL4B Gene

mRNA expression in normal human tissues for TXNL4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXNL4B Gene

SOURCE GeneReport for Unigene cluster for TXNL4B Gene Hs.134406

genes like me logo Genes that share expressions with TXNL4B: view

Orthologs for TXNL4B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXNL4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNL4B 36
  • 100 (n)
  • 100 (a)
TXNL4B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TXNL4B 36
  • 92.39 (n)
  • 97.32 (a)
TXNL4B 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC612963 36
  • 93.51 (n)
  • 97.32 (a)
TXNL4B 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Txnl4b 36
  • 87.92 (n)
  • 97.32 (a)
Txnl4b 16
Txnl4b 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TXNL4B 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Txnl4b 36
  • 88.81 (n)
  • 97.99 (a)
chicken
(Gallus gallus)
Aves TXNL4B 36
  • 81.66 (n)
  • 89.26 (a)
TXNL4B 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TXNL4B 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7085 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14990 36
txnl4b 36
  • 78.97 (n)
  • 87.25 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14498 36
txnl4b 36
  • 77.4 (n)
  • 83.89 (a)
txnl4b 37
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dim1 37
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.75 37
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIB1 37
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G24730 36
  • 61.74 (n)
  • 60.4 (a)
rice
(Oryza sativa)
Liliopsida Os11g0297900 36
  • 59.46 (n)
  • 60.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9800 37
  • 36 (a)
OneToMany
Species with no ortholog for TXNL4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNL4B Gene

ENSEMBL:
Gene Tree for TXNL4B (if available)
TreeFam:
Gene Tree for TXNL4B (if available)

Paralogs for TXNL4B Gene

Paralogs for TXNL4B Gene

Selected SIMAP similar genes for TXNL4B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TXNL4B: view

Variants for TXNL4B Gene

Sequence variations from dbSNP and Humsavar for TXNL4B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs152828 -- 72,089,987(-) TCATA(A/G)GCAGG intron-variant
rs152837 -- 72,083,852(-) tgctc(A/G)gctat intron-variant
rs172603 -- 72,087,369(+) tgtgt(A/G)tgtat intron-variant
rs217181 -- 72,080,103(-) ggtta(A/G)ggtta intron-variant
rs699450 -- 72,049,753(-) ggcac(A/G)tgcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNL4B Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv833273 CNV Loss 17160897
dgv898e1 CNV Complex 17122850
nsv428329 CNV Gain 18775914
esv2714683 CNV Deletion 23290073
esv270717 CNV Insertion 20981092

Relevant External Links for TXNL4B Gene

HapMap Linkage Disequilibrium report
TXNL4B

Disorders for TXNL4B Gene

No disorders were found for TXNL4B Gene.

No data available for UniProtKB/Swiss-Prot for TXNL4B Gene

Publications for TXNL4B Gene

  1. Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2. (PMID: 16142897) Simeoni F. … Divita G. (Biochemistry 2005) 3 4 23
  2. DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression. (PMID: 15161931) Sun X. … Shang Y. (J. Biol. Chem. 2004) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B. (PMID: 16511018) Jin T. … Zhang Y.Z. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2005) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TXNL4B Gene

  • antibodies-online proteins for TXNL4B
  • antibodies-online antibodies for TXNL4B
  • antibodies-online kits for TXNL4B

Sources for TXNL4B Gene

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