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Aliases for TXNL4B Gene

Aliases for TXNL4B Gene

  • Thioredoxin Like 4B 2 3 5
  • Dim1-Like Protein 3 4
  • Dim2 3 4
  • DLP 3 4
  • Thioredoxin-Like Protein 4B 3
  • Thioredoxin-Like 4B 2

External Ids for TXNL4B Gene

Previous GeneCards Identifiers for TXNL4B Gene

  • GC16M070677
  • GC16M057885

Summaries for TXNL4B Gene

GeneCards Summary for TXNL4B Gene

TXNL4B (Thioredoxin Like 4B) is a Protein Coding gene. An important paralog of this gene is TXNL4A.

UniProtKB/Swiss-Prot for TXNL4B Gene

  • Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.

Gene Wiki entry for TXNL4B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNL4B Gene

Genomics for TXNL4B Gene

Regulatory Elements for TXNL4B Gene

Enhancers for TXNL4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F072012 1.1 Ensembl ENCODE 25.9 +80.8 80756 2.2 ATF1 TBL1XR1 ZFP64 GATA2 FOS CREM EGR2 SMARCA5 ZBTB11 CEBPB TXNL4B HP HPR DHODH DHX38 PIR31360
GH16F072124 1.1 Ensembl ENCODE 11.4 -31.0 -31030 1.9 HDGF TBL1XR1 MLX DMAP1 ZNF48 RAD21 ZNF143 CREM ZNF654 USF2 HP DHX38 TXNL4B HPR DHODH PIR57952 PMFBP1
GH16F072072 1 ENCODE 11.9 +21.2 21218 2.0 ATF1 ARID4B DMAP1 ZNF48 SLC30A9 PAF1 NFYC MXD4 KAT8 SSRP1 HPR DHX38 TXNL4B DHODH ENSG00000260252
GH16F073045 1.8 FANTOM5 Ensembl ENCODE 3.9 -964.6 -964560 26.2 PKNOX1 MLX ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 YY1 ZNF207 DHX38 C16orf47 ZFHX3 ENSG00000271009 TXNL4B PIR53148
GH16F071483 1.1 ENCODE 4.3 +610.0 610047 1.7 HDGF ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ENSG00000247324 ZNF23 PHLPP2 TXNL4B HPR ENSG00000261611
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TXNL4B on UCSC Golden Path with GeneCards custom track

Promoters for TXNL4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000053175 831 2801 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for TXNL4B Gene

Chromosome:
16
Start:
72,044,289 bp from pter
End:
72,094,431 bp from pter
Size:
50,143 bases
Orientation:
Minus strand

Genomic View for TXNL4B Gene

Genes around TXNL4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNL4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNL4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNL4B Gene

Proteins for TXNL4B Gene

  • Protein details for TXNL4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX01-TXN4B_HUMAN
    Recommended name:
    Thioredoxin-like protein 4B
    Protein Accession:
    Q9NX01
    Secondary Accessions:
    • D3DWS6

    Protein attributes for TXNL4B Gene

    Size:
    149 amino acids
    Molecular mass:
    17015 Da
    Quaternary structure:
    • Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome.

    Three dimensional structures from OCA and Proteopedia for TXNL4B Gene

neXtProt entry for TXNL4B Gene

Post-translational modifications for TXNL4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TXNL4B Gene

Domains & Families for TXNL4B Gene

Protein Domains for TXNL4B Gene

Suggested Antigen Peptide Sequences for TXNL4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX01

UniProtKB/Swiss-Prot:

TXN4B_HUMAN :
  • Belongs to the DIM1 family.
Family:
  • Belongs to the DIM1 family.
genes like me logo Genes that share domains with TXNL4B: view

No data available for Gene Families for TXNL4B Gene

Function for TXNL4B Gene

Molecular function for TXNL4B Gene

UniProtKB/Swiss-Prot Function:
Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.

Gene Ontology (GO) - Molecular Function for TXNL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TXNL4B: view

Phenotypes for TXNL4B Gene

genes like me logo Genes that share phenotypes with TXNL4B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TXNL4B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNL4B Gene

Localization for TXNL4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNL4B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNL4B gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2

Gene Ontology (GO) - Cellular Components for TXNL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005681 spliceosomal complex IBA --
GO:0005682 U5 snRNP IBA --
GO:0046540 U4/U6 x U5 tri-snRNP complex IBA --
genes like me logo Genes that share ontologies with TXNL4B: view

Pathways & Interactions for TXNL4B Gene

SuperPathways for TXNL4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly IBA --
GO:0000398 mRNA splicing, via spliceosome IEA --
GO:0006397 mRNA processing IEA --
GO:0007049 cell cycle IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with TXNL4B: view

No data available for Pathways by source and SIGNOR curated interactions for TXNL4B Gene

Transcripts for TXNL4B Gene

Unigene Clusters for TXNL4B Gene

Thioredoxin-like 4B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNL4B Gene

No ASD Table

Relevant External Links for TXNL4B Gene

GeneLoc Exon Structure for
TXNL4B
ECgene alternative splicing isoforms for
TXNL4B

Expression for TXNL4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TXNL4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TXNL4B Gene

This gene is overexpressed in Testis (20.1), Ovary (11.2), Salivary gland (8.3), Fetal testis (8.0), Stomach (7.3), and Esophagus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXNL4B Gene



NURSA nuclear receptor signaling pathways regulating expression of TXNL4B Gene:

TXNL4B

SOURCE GeneReport for Unigene cluster for TXNL4B Gene:

Hs.134406
genes like me logo Genes that share expression patterns with TXNL4B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TXNL4B Gene

Orthologs for TXNL4B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXNL4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNL4B 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia TXNL4B 35
  • 97 (a)
OneToOne
LOC612963 34
  • 93.51 (n)
oppossum
(Monodelphis domestica)
Mammalia TXNL4B 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TXNL4B 34 35
  • 92.39 (n)
rat
(Rattus norvegicus)
Mammalia Txnl4b 34
  • 88.81 (n)
mouse
(Mus musculus)
Mammalia Txnl4b 34 16 35
  • 87.92 (n)
chicken
(Gallus gallus)
Aves TXNL4B 34 35
  • 81.66 (n)
lizard
(Anolis carolinensis)
Reptilia TXNL4B 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia txnl4b 34
  • 78.97 (n)
Str.14990 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7085 34
zebrafish
(Danio rerio)
Actinopterygii txnl4b 34 35
  • 77.4 (n)
Dr.14498 34
fruit fly
(Drosophila melanogaster)
Insecta Dim1 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.75 35
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIB1 35
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G24730 34
  • 61.74 (n)
rice
(Oryza sativa)
Liliopsida Os11g0297900 34
  • 59.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9800 35
  • 36 (a)
OneToMany
Species where no ortholog for TXNL4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNL4B Gene

ENSEMBL:
Gene Tree for TXNL4B (if available)
TreeFam:
Gene Tree for TXNL4B (if available)

Paralogs for TXNL4B Gene

Paralogs for TXNL4B Gene

(1) SIMAP similar genes for TXNL4B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TXNL4B: view

Variants for TXNL4B Gene

Sequence variations from dbSNP and Humsavar for TXNL4B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs137853233 Benign 72,057,415(+) ATAAG(A/G)AGCAG intron-variant, reference, missense
rs104894517 other 72,060,409(+) AGATA(C/T)TGGGC intron-variant, reference, missense
rs10451118 -- 72,061,873(+) GAAAG(C/G)TTCTG intron-variant, upstream-variant-2KB
rs10492813 -- 72,088,564(+) TCTTT(C/T)ATAAA intron-variant
rs10492814 -- 72,092,615(+) CAGCA(A/G)TTCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TXNL4B Gene

Variant ID Type Subtype PubMed ID
nsv833273 CNV loss 17160897
nsv7285 OTHER inversion 18451855
nsv428329 CNV gain 18775914
esv3441283 CNV insertion 20981092
esv3306441 CNV mobile element insertion 20981092
esv2758654 CNV gain 17122850
esv2714683 CNV deletion 23290073
dgv3017n100 CNV gain 25217958

Variation tolerance for TXNL4B Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNL4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNL4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNL4B Gene

Disorders for TXNL4B Gene

Relevant External Links for TXNL4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXNL4B

No disorders were found for TXNL4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNL4B Gene

Publications for TXNL4B Gene

  1. Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2. (PMID: 16142897) Simeoni F. … Divita G. (Biochemistry 2005) 3 4 22 64
  2. DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression. (PMID: 15161931) Sun X. … Shang Y. (J. Biol. Chem. 2004) 2 3 4 64
  3. Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B. (PMID: 16511018) Jin T. … Zhang Y.Z. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2005) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TXNL4B Gene

Sources for TXNL4B Gene

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