TXNL4B Gene
protein-coding GIFtS: 47
GCID: GC16M072118
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thioredoxin-like 4B
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Aliases
for TXNL4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thioredoxin-Like 4B1 2 | | FLJ205111 | | DLP1 2 3 | | Thioredoxin-Like Protein 4B2 | | Dim21 2 | | DIM23 | | Dim1-Like Protein2 3 | | |
Export aliases for TXNL4B gene to outside databasesPrevious GC identifers: GC16M070677 GC16M057885 |
Summaries
for TXNL4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TXN4B_HUMAN, Q9NX01Function: Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition
Gene Wiki entry for TXNL4B
|
Genomic Views
for TXNL4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TXNL4B gene promoter:
p53 NF-kappaB1 NF-kappaB
Other transcription factors
Search SABiosciences Chromatin IP Primers for TXNL4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNL4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.2 Ensembl cytogenetic band: 16q22.2 HGNC cytogenetic band: 16q22.2TXNL4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M072118: view genomic region
(about GC identifiers)
Start:
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72,078,188 bp from pter |
End:
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72,128,330 bp from pter |
Size:
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50,143 bases |
Orientation:
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minus strand |
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Proteins
for TXNL4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TXN4B_HUMAN, Q9NX01 (See
protein sequence)Recommended Name: Thioredoxin-like protein 4B Size: 149 amino acids; 17015 Da
Subunit: Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome
Subcellular location: Nucleus
2 PDB 3D structures from  and Proteopedia  for TXNL4B:1XBS (3D)
3GIX (3D)
Secondary accessions: D3DWS6Explore the universe of human proteins at neXtProt for TXNL4B: NX_Q9NX01
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NX01
TXNL4B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001135789.1 NP_001135790.1 NP_060323.1
ENSEMBL proteins: ENSP00000454635 ENSP00000268483 ENSP00000392310 ENSP00000455550 ENSP00000457699 ENSP00000408130
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005681 | spliceosomal complex |
IEA | -- |
TXNL4B for ontologies About GeneDecksing
TXNL4B Antibody Products:
Assay Products for TXNL4B: |
Protein
Domains /
Families
for TXNL4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TXNL4B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NX01ProtoNet protein and cluster: Q9NX01 1 Blocks protein family: IPB004123 Pre-mRNA splicing protein
UniProtKB/Swiss-Prot: TXN4B_HUMAN, Q9NX01Similarity: Belongs to the DIM1 family |
Function
for TXNL4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TXN4B_HUMAN, Q9NX01Function: Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNL4B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNL4B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TXNL4B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNL4B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNL4B |
|
Pathways & Interactions
for TXNL4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TXNL4B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/12 Interacting proteins for TXNL4B (Q9NX013 ENSP000002684834) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
TXNL4B for ontologies About GeneDecksing
|
Drugs & Compounds
for TXNL4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TXNL4B
Search CenterWatch for drugs/clinical trials and news about TXNL4B / TXN4B
|
Transcripts
for TXNL4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TXNL4B gene (3 alternative transcripts): NM_001142317.1 NM_001142318.1 NM_017853.2 Unigene Cluster for TXNL4B: Thioredoxin-like 4B Hs.134406 [show with all ESTs]Unigene Representative Sequence: NM_0178536 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000562153 ENST00000268483(uc010cgl.2 uc002fca.3 uc010vmo.2)
ENST00000426362 ENST00000565171 ENST00000569767 ENST00000423037(uc010vmn.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNL4B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNL4B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TXNL4B (NM_001142318) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TXNL4B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNL4B |
Additional cDNA sequence: AK000518.1 AK222889.1 AK308891.1 AY566808.1 BC009646.1 CR457240.1 12 DOTS entries: DT.442091 DT.100758093 DT.120676175 DT.120676237 DT.91893224 DT.100743517 DT.120676186 DT.91871062 DT.95164976 DT.97841859 DT.100786705 DT.92028303 24/125 AceView cDNA sequences (see all 125): AA373245 BM561632 CD517462 BE018752 AI279309 BQ007095 BU631267 BE409023 BF593392 BU172712 BU739352 AI810585 BP345992 BM916990 F09985 AI767304 BF055190 AY566808 BM700475 BM714705 BE463736 AA830905 AI052723 AA306102
GeneLoc Exon Structure
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Expression
for TXNL4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TXNL4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTCTGGAC
About this image
See TXNL4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TXNL4B
SOURCE GeneReport for Unigene cluster: Hs.134406
SABiosciences Expression via Pathway-Focused PCR Arrays including TXNL4B:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXNL4B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXNL4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNL4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNL4B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNL4B |
Orthologs
for TXNL4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TXNL4B gene from 7/17 species (see all 17) About this table
ENSEMBL Gene Tree for TXNL4B (if available)
TreeFam Gene Tree for TXNL4B (if available) |
Paralogs
for TXNL4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TXNL4B gene
- TXNL4A2
1 SIMAP similar gene for TXNL4B using alignment to 5 protein entries: TXN4B_HUMAN (see all proteins):TXNL4A
TXNL4B for paralogs About GeneDecksing
|
Genomic Variants
for TXNL4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TXNL4B (72078188 - 72128330 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TXNL4B
3 CNVs: 88199 4011 88202 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TXNL4B |
|
Disorders
/ Diseases
for TXNL4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TXNL4B for disorders About GeneDecksing
3  diseases for TXNL4B: About MalaCardsherpes simplex hypercholesterolemia osteosarcoma
Export disorders for TXNL4B gene to outside databases
|
Publications
for TXNL4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TXNL4B gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with TXNL4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression. (PubMed id 15161931)1, 2, 3 Sun X.... Shang Y. (2004)
- Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2. (PubMed id 16142897)1, 2, 9 Simeoni F.... Divita G. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B. (PubMed id 16511018)1, 9 Jin T....Zhang Y.Z. (2005)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A protein inventory of human ribosome biogenesis reve als an essential function of exportin 5 in 60S subunit export. (PubMed id 21048991)1 Wild T....Kutay U. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
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External Searches for TXNL4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TXNL4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TXNL4B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TXNL4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TXNL4B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TXNL4B gene:
Search GeneIP for patents involving TXNL4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TXNL4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TXNL4B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TXNL4B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXNL4B | | | OriGene Protein Over-expression Lysate for TXNL4B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TXNL4B | | OriGene 3'-UTR Clone for TXNL4B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNL4B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNL4B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TXNL4B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  |  |  |  | | | | | | Recombinant Protein for TXNL4B |
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 | | | TXNL4B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNL4B |
|  |  |  | | | | Search ThermoFisher Antibodies for TXNL4B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNL4B |
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