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TXNL4A Gene

protein-coding   GIFtS: 58
GCID: GC18M077732

Thioredoxin-Like 4A

(Previous name: thioredoxin-like 4)
(Previous symbol: TXNL4)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin-Like 4A1 2     Similar To S. Pombe Dim1+1
TXNL41 2 3     DIB12
DIM12 3 5     HsT1612
Thioredoxin-Like 41 2     SNRNP152
Spliceosomal U5 SnRNP-Specific 15 KDa Protein2 3     U5-15kD2
Thioredoxin-Like U5 SnRNP Protein U5-15kD2 3     Thioredoxin-Like Protein 4A2
DIM1 Protein Homolog2 3     

External Ids:    HGNC: 305511   Entrez Gene: 109072   Ensembl: ENSG000001417597   OMIM: 6115955   UniProtKB: P838763   

Export aliases for TXNL4A gene to outside databases

Previous GC identifers: GC18M075833 GC18M074354


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TXNL4A Gene:
TXNL4A (thioredoxin-like 4A) is a protein-coding gene. Diseases associated with TXNL4A include malaria. An important paralog of this gene is TXNL4B.

UniProtKB/Swiss-Prot: TXN4A_HUMAN, P83876
Function: Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that
are involved in spliceosome assembly

Gene Wiki entry for TXNL4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TXNL4A gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-2   Pax-2a   Nkx3-1 v1   Nkx3-1 v2   CREB   deltaCREB   Nkx3-1 v3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TXNL4A promoter sequence
   Search Chromatin IP Primers for TXNL4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXNL4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q23

TXNL4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNL4A gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M077732:  view genomic region     (about GC identifiers)

Start:
77,732,867 bp from pter      End:
77,793,949 bp from pter
Size:
61,083 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TXN4A_HUMAN, P83876 (See protein sequence)
Recommended Name: Thioredoxin-like protein 4A  
Size: 142 amino acids; 16786 Da
Subunit: Interacts with HNRPF, HNRPH2, NEDD9, ERBB4, and PQBP1. Component of the U5 snRNP complex. Component of
the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8,
PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Directly interacts with
CD2BP2
3 PDB 3D structures from and Proteopedia for TXNL4A:
1PQN (3D)        1QGV (3D)        1SYX (3D)    
Secondary accessions: B2RC18 O14834

Explore the universe of human proteins at neXtProt for TXNL4A: NX_P83876

Explore proteomics data for TXNL4A at MOPED

Post-translational modifications: 

  • The disulfide bond seen in structures determined by X-ray crystallography (PubMed:10610776) and NMR
    (PubMed:12911302) is not essential for protein folding and function (PubMed:12911302 and PubMed:17467737)1
  • Ubiquitination2 at Lys134, Lys139
  • Modification sites at PhosphoSitePlus

  • See TXNL4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006692.1  
    ENSEMBL proteins: 
     ENSP00000269601   ENSP00000465572   ENSP00000465321   ENSP00000465493   ENSP00000347678  
     ENSP00000466266   ENSP00000468761   ENSP00000468493   ENSP00000467304   ENSP00000466694  
    Reactome Protein details: P83876

    TXNL4A Human Recombinant Protein Products:

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    Novus Biologicals TXNL4A Proteins
    Novus Biologicals TXNL4A Lysate
    Sino Biological Recombinant Protein for TXNL4A
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TXNL4A
    Browse Proteins at Cloud-Clone Corp.

    TXNL4A Antibody Products:

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    Search LSBio for Antibodies for TXNL4A

    TXNL4A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR004123 mRNA_splic_U5

    Graphical View of Domain Structure for InterPro Entry P83876

    ProtoNet protein and cluster: P83876

    1 Blocks protein domain: IPB004123 Pre-mRNA splicing protein

    UniProtKB/Swiss-Prot: TXN4A_HUMAN, P83876
    Similarity: Belongs to the DIM1 family


    TXNL4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXN4A_HUMAN, P83876
    Function: Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that
    are involved in spliceosome assembly

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15840814
         
    TXNL4A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TXNL4A:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TXNL4A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TXNL4A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TXNL4A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TXNL4A

    miRNA
    Products:
        
    miRTarBase miRNAs that target TXNL4A:
    hsa-mir-193b-3p (MIRT041224), hsa-let-7b-5p (MIRT052139), hsa-mir-23a-3p (MIRT050419), hsa-mir-1301-3p (MIRT036005)

    Block miRNA regulation of human, mouse, rat TXNL4A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TXNL4A
    SwitchGear 3'UTR luciferase reporter plasmidTXNL4A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TXNL4A

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TXNL4A (see all 7)
    OriGene ORF clones in mouse, rat for TXNL4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TXNL4A (NM_006701)
    Sino Biological Human cDNA Clone for TXNL4A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNL4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNL4A

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TXNL4A
    Browse ESI BIO Cell Lines and PureStem Progenitors for TXNL4A 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNL4A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TXN4A_HUMAN, P83876: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex TAS10610776
    GO:0005737cytoplasm ----

    TXNL4A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TXNL4A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA processing0.44
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    mRNA Splicing0.78
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TXNL4A
        mRNA processing


    2 Reactome Pathways for TXNL4A
        mRNA Splicing - Major Pathway
    mRNA Splicing - Minor Pathway


    1 Kegg Pathway  (Kegg details for TXNL4A):
        Spliceosome


    TXNL4A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TXNL4A
    Interactions:

        Search GeneGlobe Interaction Network for TXNL4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TXNL4A (P838761, 2, 3 ENSP000002696014) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000172850Q9Y3333, ENSP000003728834I2D: score=2 STRING: ENSP00000372883
    ENSG00000224979Q9Y3333, ENSP000004140064I2D: score=2 STRING: ENSP00000414006
    ENSG00000225998Q9Y3333, ENSP000004062804I2D: score=2 STRING: ENSP00000406280
    ENSG00000231502Q9Y3333, ENSP000004033454I2D: score=2 STRING: ENSP00000403345
    ENSG00000236826Q9Y3333, ENSP000004146344I2D: score=2 STRING: ENSP00000414634
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000245spliceosomal complex assembly TAS10610776
    GO:0000375RNA splicing, via transesterification reactions TAS10610776
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0007067mitosis IEA--
    GO:0008380RNA splicing TAS--

    TXNL4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TXNL4A (TXN4A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TXNL4A gene: 
    NM_006701.2  

    Unigene Cluster for TXNL4A:

    Thioredoxin-like 4A
    Hs.465498  [show with all ESTs]
    Unigene Representative Sequence: BM564448
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269601(uc002lnp.3 uc002lnr.3 uc010drf.3 uc010drg.3)
    ENST00000585474 ENST00000588162 ENST00000592957 ENST00000355491 ENST00000585769
    ENST00000586612 ENST00000592837 ENST00000591711 ENST00000586825 ENST00000586295
    ENST00000589926
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TXNL4A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TXNL4A
    SwitchGear 3'UTR luciferase reporter plasmidTXNL4A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TXNL4A
    Predesigned siRNA for gene silencing in human, mouse, rat TXNL4A
    Clone
    Products:
         
    OriGene clones in human, mouse for TXNL4A (see all 7)
    OriGene ORF clones in mouse, rat for TXNL4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TXNL4A (NM_006701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNL4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNL4A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TXNL4A
    OriGene qSTAR qPCR primer pairs in human, mouse for TXNL4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TXNL4A
      QuantiTect SYBR Green Assays in human, mouse, rat TXNL4A
      QuantiFast Probe-based Assays in human, mouse, rat TXNL4A

    Additional mRNA sequence: 

    AF023611.1 AF023612.1 AF146373.1 AK308703.1 AK309098.1 AK314901.1 BC001046.2 BC019272.1 

    11 DOTS entries:

    DT.443056  DT.100797796  DT.100797797  DT.92442793  DT.100797799  DT.97766758  DT.92442797  DT.100797794 
    DT.95239734  DT.92022880  DT.95086313 

    Selected AceView cDNA sequences (see all 225):

    NM_006701 AI299030 BI963007 AI859064 CR621222 BU740326 AL138218 BF002576 
    BC001046 CB178596 BM470892 AI814618 CD676530 AF146373 BE385528 BM992294 
    BC019272 AI088600 BM822382 BU849046 AI381227 CR625676 AW731951 AF023611 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TXNL4A (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
    SP1:                                -     -           -                                       
    SP2:              -                 -     -           -     -                                 
    SP3:                    -     -     -     -           -                                       
    SP4:                                -     -           -     -                                 
    SP5:                    -     -     -     -           -     -                                 


    ECgene alternative splicing isoforms for TXNL4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TXNL4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTTAACTC
    TXNL4A Expression
    About this image

    TXNL4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TXNL4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465498
        Custom PCR Arrays for TXNL4A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TXNL4A
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    QuantiFast Probe-based Assays in human, mouse, rat TXNL4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNL4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TXNL4A gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txnl4a1 , 5 thioredoxin-like 4A1, 5 89.91(n)1
    100(a)1
      18 (53.34 cM)5
    273661  NM_025299.31  NP_079575.11 
     802067955 
    chicken
    (Gallus gallus)
    Aves TXNL4A1 thioredoxin-like 4A 83.57(n)
    99.3(a)
      420811  XM_418903.4  XP_418903.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    99(a)
    99(a)
    many ↔ many
    many ↔ many
    GL344604.1(6831-16409)
    4(53139228-53147065)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.81192 Xenopus laevis transcribed sequence with strong similarity more 81.86(n)    48034408 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.233532 Transcribed sequence with strong similarity to protein more 82.13(n)    57090401 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dim11 Dim1 83.33(n)
    95.77(a)
      33645  NM_134986.3  NP_608830.3 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54G2A.756
    Protein Y54G2A.75 (Y54G2A.75) mRNA, complete cds
    87(a)
    1 → many
    IV(2890890-2891579) WBGene00235102
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIB1(YPR082C)4
    DIB11
    17-kDa component of the U4/U6aU5 tri-snRNP, plays an more4
    DIB11
    60.87(n)1
    65.94(a)1
      16(704656-704225)4
    8561971, 4  NP_015407.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons YLS81 YLS8 75.35(n)
    85.21(a)
      830725  NM_120912.2  NP_196446.1 
    rice
    (Oryza sativa)
    Liliopsida Os.123682 Oryza sativa (japonica cultivar-group) cDNA clone0 more 78.66(n)    AK063786.1 


    ENSEMBL Gene Tree for TXNL4A (if available)
    TreeFam Gene Tree for TXNL4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TXNL4A gene
    TXNL4B2  
    1 SIMAP similar gene for TXNL4A using alignment to 7 protein entries:     TXN4A_HUMAN (see all proteins):
    TXNL4B

    TXNL4A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TXNL4A
    PGOHUM00000241035


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TXNL4A (see all 374)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809876871,2
    C--77732392(+) GGACAA/CGAAGA 1 -- int10--------
    rs1508325691,2
    C--77732393(+) GACACG/TAAGAT 1 -- int10--------
    rs3690571001,2
    C--77732476(+) TTTTC-/TTTTTT
            
    TGAGA
    1 -- int10--------
    rs1865407891,2
    --77732557(+) CCTCCC/TGGGTT 1 -- int10--------
    rs1897571981,2
    --77732677(+) CCAGGA/CTGGTC 1 -- int10--------
    rs1814044621,2
    --77732709(+) CTGCCC/TACCTC 1 -- int10--------
    rs1393007291,2
    C--77732710(+) TGCCCA/GCCTCG 1 -- int10--------
    rs1857554481,2
    --77732715(+) ACCTCA/GGCCTC 1 -- int10--------
    rs1905590661,2
    --77732738(+) GATTAC/TAGGTG 1 -- int10--------
    rs1831806911,2
    --77732878(+) ACAGGA/GAAGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TXNL4A (77732867 - 77793949 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TXNL4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470437CNV Loss18288195
    nsv910039CNV Loss21882294
    dgv3492n71CNV Loss21882294
    nsv910009CNV Loss21882294
    nsv428359CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611595    OMIM disorders: --

    1 disease for TXNL4A:    About MalaCards
    malaria


    TXNL4A for disorders           About GeneDecksing


    Export disorders for TXNL4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TXNL4A gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with TXNL4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily. (PubMed id 11015569)1, 2, 3 Zhang Y.-Z....Golemis E.A. (Physiol. Genomics 1999)
    2. Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15kD protein. (PubMed id 10610776)1, 2, 9 Reuter K.... Ficner R. (J. Mol. Biol. 1999)
    3. The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. (PubMed id 16723661)1, 2 Liu S.... Luehrmann R. (RNA 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Structure, stability, and function of hDim1 investigated by NMR, circular dichroism, and mutational analysis. (PubMed id 12911302)1, 2 Zhang Y.Z.... Roder H. (Biochemistry 2003)
    6. Evidence that Dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for Dim1 interactions with hnRNP F and Npw38/PQBP-1. (PubMed id 11054566)1, 2 Zhang Y.-Z....Golemis E.A. (Gene 2000)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10907 HGNC: 30551 AceView: TXNL4A Ensembl:ENSG00000141759 euGenes: HUgn10907
    ECgene: TXNL4A Kegg: 10907 H-InvDB: TXNL4A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TXNL4A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TXNL4A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TXNL4A gene:
    Search GeneIP for patents involving TXNL4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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