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Aliases for TXNL1 Gene

Aliases for TXNL1 Gene

  • Thioredoxin-Like 1 2 3
  • TXNL 3 4 6
  • 32 KDa Thioredoxin-Related Protein 3 4
  • TRP32 3 4
  • Txl 3 4
  • Epididymis Secretory Protein Li 114 3
  • Thioredoxin-Related 32 KDa Protein 3
  • Thioredoxin-Related Protein 1 3
  • Thioredoxin-Like Protein 1 3
  • Thioredoxin-Like, 32kDa 2
  • Thioredoxin-Like 2
  • HEL-S-114 3
  • TXL-1 3
  • 32kD 2

External Ids for TXNL1 Gene

Previous HGNC Symbols for TXNL1 Gene

  • TXNL

Previous GeneCards Identifiers for TXNL1 Gene

  • GC18M052420
  • GC18M052421
  • GC18M054264
  • GC18M050981

Summaries for TXNL1 Gene

GeneCards Summary for TXNL1 Gene

TXNL1 (Thioredoxin-Like 1) is a Protein Coding gene. Diseases associated with TXNL1 include thymus adenocarcinoma. GO annotations related to this gene include electron carrier activity and disulfide oxidoreductase activity. An important paralog of this gene is TXN.

UniProtKB/Swiss-Prot for TXNL1 Gene

  • Active thioredoxin with a redox potential of about -250 mV.

Gene Wiki entry for TXNL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNL1 Gene

Genomics for TXNL1 Gene

Regulatory Elements for TXNL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TXNL1 Gene

Start:
56,597,208 bp from pter
End:
56,651,600 bp from pter
Size:
54,393 bases
Orientation:
Minus strand

Genomic View for TXNL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNL1 Gene

Proteins for TXNL1 Gene

  • Protein details for TXNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43396-TXNL1_HUMAN
    Recommended name:
    Thioredoxin-like protein 1
    Protein Accession:
    O43396
    Secondary Accessions:

    Protein attributes for TXNL1 Gene

    Size:
    289 amino acids
    Molecular mass:
    32251 Da
    Quaternary structure:
    • Component of the 19S regulatory cap of the 26S proteasome. Interacts with PSMD14/RPN11. Interacts with, and reduces EEF1A1.

    Three dimensional structures from OCA and Proteopedia for TXNL1 Gene

neXtProt entry for TXNL1 Gene

Proteomics data for TXNL1 Gene at MOPED

Post-translational modifications for TXNL1 Gene

  • Ubiquitination at Lys5, Lys28, Lys102, Lys104, Lys181, and Lys279
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNL1 Gene

Antibody Products

No data available for DME Specific Peptides for TXNL1 Gene

Domains for TXNL1 Gene

Suggested Antigen Peptide Sequences for TXNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43396

UniProtKB/Swiss-Prot:

TXNL1_HUMAN :
  • O43396
Domain:
  • Contains 1 PITH domain.
  • Contains 1 thioredoxin domain.
genes like me logo Genes that share domains with TXNL1: view

No data available for Gene Families for TXNL1 Gene

Function for TXNL1 Gene

Molecular function for TXNL1 Gene

UniProtKB/Swiss-Prot Function:
Active thioredoxin with a redox potential of about -250 mV.

Gene Ontology (GO) - Molecular Function for TXNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015035 protein disulfide oxidoreductase activity IBA --
GO:0015036 disulfide oxidoreductase activity IDA 9668102
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA --
genes like me logo Genes that share ontologies with TXNL1: view

Animal Model Products

miRNA for TXNL1 Gene

miRTarBase miRNAs that target TXNL1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TXNL1 Gene

Localization for TXNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNL1 Gene

Cytoplasm. Nucleus. Note=At least 85% of the cellular TXNL1 is proteasome-associated.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXNL1 Gene COMPARTMENTS Subcellular localization image for TXNL1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TXNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TXNL1: view

Pathways for TXNL1 Gene

SuperPathways for TXNL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000103 sulfate assimilation IBA --
GO:0006457 protein folding IBA --
GO:0006662 glycerol ether metabolic process IEA --
GO:0034599 cellular response to oxidative stress IBA --
GO:0045454 cell redox homeostasis IBA --
genes like me logo Genes that share ontologies with TXNL1: view

No data available for Pathways by source for TXNL1 Gene

Compounds for TXNL1 Gene

(1) Novoseek inferred chemical compound relationships for TXNL1 Gene

Compound -log(P) Hits PubMed IDs
glucose 15.6 1
genes like me logo Genes that share compounds with TXNL1: view

Transcripts for TXNL1 Gene

Unigene Clusters for TXNL1 Gene

Thioredoxin-like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXNL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - -
SP2: -
SP3:
SP4:
SP5: -
SP6: -

Relevant External Links for TXNL1 Gene

GeneLoc Exon Structure for
TXNL1
ECgene alternative splicing isoforms for
TXNL1

Expression for TXNL1 Gene

mRNA expression in normal human tissues for TXNL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TXNL1 Gene

SOURCE GeneReport for Unigene cluster for TXNL1 Gene Hs.114412

mRNA Expression by UniProt/SwissProt for TXNL1 Gene

O43396-TXNL1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with TXNL1: view

Expression partners for TXNL1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for TXNL1 Gene

Orthologs for TXNL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXNL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TXNL1 35
  • 94.35 (n)
  • 99.31 (a)
TXNL1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TXNL1 35
  • 95.85 (n)
  • 99.31 (a)
TXNL1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Txnl1 35
  • 92.73 (n)
  • 98.62 (a)
Txnl1 16
Txnl1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TXNL1 35
  • 99.88 (n)
  • 100 (a)
TXNL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Txnl1 35
  • 92.39 (n)
  • 98.96 (a)
oppossum
(Monodelphis domestica)
Mammalia TXNL1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TXNL1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves TXNL1 35
  • 85.01 (n)
  • 91.7 (a)
TXNL1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TXNL1 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5938 35
txnl1 35
  • 78.43 (n)
  • 84.08 (a)
zebrafish
(Danio rerio)
Actinopterygii txnl1 35
  • 74.74 (n)
  • 80.62 (a)
zgc55368 35
txnl1 36
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10705 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005462 35
  • 51.52 (n)
  • 49.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Txl 35
  • 53.77 (n)
  • 49.83 (a)
Txl 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y54E10A.3 35
  • 53.02 (n)
  • 46.01 (a)
Y54E10A.3 36
  • 45 (a)
OneToMany
Y55F3AR.2 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRX1 36
  • 32 (a)
ManyToMany
TRX2 36
  • 27 (a)
ManyToMany
TRX3 36
  • 22 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G04780 35
  • 53.09 (n)
  • 45.68 (a)
rice
(Oryza sativa)
Liliopsida Os03g0795500 35
  • 51.28 (n)
  • 40.83 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02520 35
  • 46.67 (n)
  • 33.04 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes txl1 35
  • 50.61 (n)
  • 41.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2149 36
  • 44 (a)
OneToOne
Species with no ortholog for TXNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNL1 Gene

ENSEMBL:
Gene Tree for TXNL1 (if available)
TreeFam:
Gene Tree for TXNL1 (if available)

Paralogs for TXNL1 Gene

Paralogs for TXNL1 Gene

Selected SIMAP similar genes for TXNL1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for TXNL1 Gene

genes like me logo Genes that share paralogs with TXNL1: view

Variants for TXNL1 Gene

Sequence variations from dbSNP and Humsavar for TXNL1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs14387 -- 56,626,427(-) CCAGC(A/G/T)TTCAG reference, synonymous-codon, nc-transcript-variant
rs479806 -- 56,601,871(+) AATAG(A/G)TATTT utr-variant-3-prime, nc-transcript-variant
rs481522 -- 56,622,636(+) CATTT(C/T)TTCCT intron-variant
rs483405 -- 56,636,947(+) CATCA(A/C)AAAAT intron-variant
rs496102 -- 56,597,303(+) TGTCA(C/T)GTAAA utr-variant-3-prime, nc-transcript-variant

Relevant External Links for TXNL1 Gene

HapMap Linkage Disequilibrium report
TXNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TXNL1 Gene

Disorders for TXNL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TXNL1 Gene in MalaCards »

(1) Diseases for TXNL1 Gene including...

(3) University of Copenhagen DISEASES for TXNL1 Gene

Relevant External Links for TXNL1

Genetic Association Database (GAD)
TXNL1
Human Genome Epidemiology (HuGE) Navigator
TXNL1
genes like me logo Genes that share disorders with TXNL1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for TXNL1 Gene

Publications for TXNL1 Gene

  1. Molecular cloning and expression of a cDNA encoding a human thioredoxin-like protein. (PMID: 9473519) Miranda-Vizuete A. … Spyrou G. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa. (PMID: 9668102) Lee K.-K. … Yonehara S. (J. Biol. Chem. 1998) 2 3 4 23
  3. Genomic structure and chromosomal localization of human thioredoxin- like protein gene (txl). (PMID: 10826702) Miranda-Vizuete A. … Spyrou G. (DNA Seq. 2000) 3 4 23
  4. Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome. (PMID: 19349277) Andersen K.M. … Hartmann-Petersen R. (J. Biol. Chem. 2009) 3 4 23
  5. Solution structure of the C-terminal DUF1000 domain of the human thioredoxin-like 1 protein. (PMID: 20455272) Goroncy A.K. … Yokoyama S. (Proteins 2010) 3 4 23

Products for TXNL1 Gene

Sources for TXNL1 Gene

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