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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TXNL1 Gene

protein-coding GIFtS: 53
GCID: GC18M054264

thioredoxin-like 1

(Previous names: thioredoxin-like, 32kDa )
(Previous symbol: TXNL)

Explore 10 diseases affiliated with
TXNL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Thioredoxin-Like 1¹ ²		TXL-1²
TRP32¹ ² ³		Thioredoxin-Like Protein 1²
TXNL¹ ² ³		Thioredoxin-Related 32 KDa Protein²
Txl¹ ²		Thioredoxin-Related Protein 1²
32 KDa Thioredoxin-Related Protein² ³		TXL³
Thioredoxin-Like, 32kDa¹

External Ids:	HGNC: 12436¹	Entrez Gene: 9352²	Ensembl: ENSG00000091164⁷	OMIM: 603049⁵	UniProtKB: O43396³

Export aliases for TXNL1 gene to outside databases

Previous GC identifers: GC18M052420 GC18M052421 GC18M050981

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TXNL1_HUMAN, O43396

Function: Active thioredoxin with a redox potential of about -250 mV

Gene Wiki entry for TXNL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_025028.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TXNL1 gene promoter:
AP-1 ATF-2 Meis-1b AREB6 CREB deltaCREB PPAR-gamma2 c-Jun Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TXNL1 promoter sequence

Search SABiosciences Chromatin IP Primers for TXNL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.31 Ensembl cytogenetic band: 18q21.31 HGNC cytogenetic band: 18q21.31

TXNL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNL1 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M054264: view genomic region (about GC identifiers)

Start:	54,264,439 bp from pter	End:	54,318,831 bp from pter
Size:	54,393 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TXNL1_HUMAN, O43396 (See protein sequence)

Recommended Name: Thioredoxin-like protein 1

Size: 289 amino acids; 32251 Da

Subunit: Component of the 19S regulatory cap of the 26S proteasome. Interacts with PSMD14/RPN11. Interacts with, and

reduces EEF1A1

Subcellular location: Cytoplasm. Nucleus. Note=At least 85% of the cellular TXNL1 is proteasome-associated

2 PDB 3D structures from and Proteopedia for TXNL1:

1GH2 (3D)

1WWY (3D)

Explore the universe of human proteins at neXtProt for TXNL1: NX_O43396

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43396

TXNL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004777.1

ENSEMBL proteins:

ENSP00000217515 ENSP00000464918 ENSP00000467317 ENSP00000466473 ENSP00000468165

ENSP00000466558 ENSP00000465606 ENSP00000440251

Human Recombinant Protein Products for TXNL1:

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	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for TXNL1
	Uscn Proteins for TXNL1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	--

TXNL1 for ontologies About GeneDecksing

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	Uscn Antibodies for TXNL1
	ThermoFisher Antibodies for TXNL1

Assay Products for TXNL1:

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	Uscn ELISAs and CLIAs for TXNL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TXNL1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR013766 Thioredoxin_domain

IPR017937 Thioredoxin_CS

IPR005746 Thioredoxin

IPR012336 Thioredoxin-like_fold

IPR008979 Galactose-bd-like

Graphical View of Domain Structure for InterPro Entry O43396

ProtoNet protein and cluster: O43396

1 Blocks protein family: IPB006662 Thioredoxin type domain

UniProtKB/Swiss-Prot: TXNL1_HUMAN, O43396

Similarity: Contains 1 PITH domain

Similarity: Contains 1 thioredoxin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TXNL1_HUMAN, O43396

Function: Active thioredoxin with a redox potential of about -250 mV

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009055	electron carrier activity	IEA	--
GO:0015035	protein disulfide oxidoreductase activity	IEA	--
GO:0015036	disulfide oxidoreductase activity	IDA	9668102

TXNL1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TXNL1

miRNA Products:		OriGene 3'-UTR Clone: TXNL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNL1
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNL1:
		hsa-miR-3139 hsa-miR-708 hsa-miR-199a-5p hsa-miR-182 hsa-miR-593 hsa-miR-199b-5p hsa-miR-3908 hsa-miR-28-5p

		SwitchGear 3'UTR luciferase reporter plasmid: TXNL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TXNL1 (see all 7) OriGene shRNA RFP: TXNL1 OriGene siRNA: TXNL1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against TXNL1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TXNL1
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNL1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TXNL1 (NM_004786)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TXNL1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNL1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TXNL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/19 Interacting proteins for TXNL1 (O43396³ ENSP00000217515⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSMD6	Q15008³, ENSP00000295901⁴	I2D: score=1 STRING: ENSP00000295901
SH3BP4	Q9P0V3³, ENSP00000340237⁴	I2D: score=1 STRING: ENSP00000340237
SUMO4	Q6EEV6³, ENSP00000318635⁴	I2D: score=1 STRING: ENSP00000318635
USP14	P54578³, ENSP00000261601⁴	I2D: score=2 STRING: ENSP00000261601
UCHL5	Q9Y5K5³, ENSP00000356425⁴	I2D: score=2 STRING: ENSP00000356425

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006662	glycerol ether metabolic process	IEA	--
GO:0022900	electron transport chain	IEA	--
GO:0045454	cell redox homeostasis	IEA	--

TXNL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TXNL1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TXNL1
1 Novoseek chemical compound relationship for TXNL1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	15.6	1	16438969 (1)

Search CenterWatch for drugs/clinical trials and news about TXNL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TXNL1 gene:

NM_004786.2

Unigene Cluster for TXNL1:

Thioredoxin-like 1

Hs.114412 [show with all ESTs]

Unigene Representative Sequence: BX640857

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000217515 ENST00000585497 ENST00000588615 ENST00000590954 ENST00000587807

ENST00000589931 ENST00000586262 ENST00000587613 ENST00000589329 ENST00000589415

ENST00000586079 ENST00000540155(uc010xdz.2 uc002lgg.3 uc002lgh.3 uc002lgi.3 uc002lgj.1)

miRNA Products:		OriGene 3'-UTR Clone: TXNL1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNL1
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNL1:
		hsa-miR-3139 hsa-miR-708 hsa-miR-199a-5p hsa-miR-182 hsa-miR-593 hsa-miR-199b-5p hsa-miR-3908 hsa-miR-28-5p

		SwitchGear 3'UTR luciferase reporter plasmid: TXNL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TXNL1 (see all 7) OriGene shRNA RFP: TXNL1 OriGene siRNA: TXNL1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against TXNL1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNL1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TXNL1 (NM_004786)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXNL1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNL1

Additional cDNA sequence:

AB209263.1 AF003938.1 AF051896.1 AF052659.1 AK094926.1 AK313653.1 BC001156.1 BX640857.1

NR_024546.1

11 DOTS entries:

DT.453897 DT.92407349 DT.91850846 DT.451926 DT.95188792 DT.75157992 DT.40221703 DT.92440791

DT.95188791 DT.100644040 DT.92326962

24/320 AceView cDNA sequences (see all 320):

BQ220201 CA314678 BM928276 C00325 H80352 AV728382 AA913184 AA987812

AI339963 AA923115 AW627491 AA600928 AA721740 CD365235 AW474814 BM551063

AA845477 AI095268 BM746946 CB128664 AI291452 AI929526 AI816388 BE887614

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TXNL1 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	^	13
SP1:																					-														-
SP2:																					-
SP3:
SP4:
SP5:							-

ECgene alternative splicing isoforms for TXNL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TXNL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATTGTAAA

About this image

TXNL1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Mandibular Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TXNL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TXNL1

SOURCE GeneReport for Unigene cluster: Hs.114412

UniProtKB/Swiss-Prot: TXNL1_HUMAN, O43396

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for TXNL1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXNL1 gene from 8/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TXNL1¹	thioredoxin-like 1	85.01(n) 91.7(a)		426854 XM_424463.3 XP_424463.1
lizard (Anolis carolinensis)	Reptilia	TXNL1⁶	--	89(a)	1 ↔ 1	GL343213.1(1444611-1458601)
African clawed frog (Xenopus laevis)	Amphibia	CA981215.1²	--	78.07(n)		CA981215.1
zebrafish (Danio rerio)	Actinopterygii	zgc55368²	similar to thioredoxin-like, 32kDa	75.85(n)		394113 BC045322.1
fruit fly (Drosophila melanogaster)	Insecta	Txl¹	Thioredoxin-like	53.77(n) 49.83(a)		38646 NM_079214.3 NP_523938.2
worm (Caenorhabditis elegans)	Secernentea	Y54E10A.3¹	Protein Y54E10A.3	53.02(n) 46.01(a)		171897 NM_058726.3 NP_491127.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G04780¹	hypothetical protein	52.06(n) 44.44(a)		819638 NM_111350.2 NP_566238.1
rice (Oryza sativa)	Liliopsida	Os03g0795500¹	hypothetical protein	51.28(n) 40.83(a)		4334415 NM_001058084.1 NP_001051549.1

ENSEMBL Gene Tree for TXNL1 (if available)
TreeFam Gene Tree for TXNL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TXNL1 gene

TXNDC8² TXN² TXNDC2²

2 SIMAP similar genes for TXNL1 using alignment to 7 protein entries: TXNL1_HUMAN (see all proteins):

TXNDC8 TXN

TXNL1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TXNL1
PGOHUM00000248656

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34382500^1,2	C	--	50999803(+)	`ATGTA-/TTTTTT`	1	--	int¹		1		NA	2
rs74346665^1,2	F	--	54269581(+)	`TTTCCC/TCAACT`	2	--	ds500¹		1		EA	120
rs181231273^1,2		--	54269852(+)	`TTAGCC/TGTTCC`	2	--	ds500¹		0	--	--	--	--
rs146175827^1,2	C	--	54269903(+)	`ATGTA-/CTTCTTAA`	2	--	ds500¹		0	--	--	--	--
rs140975005^1,2		--	54269994(+)	`AATCAG/TAAGTT`	2	--	ds500¹		0	--	--	--	--
rs186255005^1,2		--	54270002(+)	`GTTAAC/TCAGTT`	2	--	ds500¹		0	--	--	--	--
rs661981^1,2	C,F,A,H	--	54270044(-)	`TTGTCA/TTTCTA`	2	--	ds500¹		21		MN NA NS EA WA CSA	1114
rs144935101^1,2		--	54270052(+)	`CAAAAA/GTTAAG`	2	--	ds500¹		0	--	--	--	--
rs77471888^1,2		--	54270111(+)	`CAATGG/AAAACA`	2	--	nc-transcript-variantut3¹		1		NA	120
rs654563^1,2	H	--	54270469(+)	`CAAGGA/GATTAA`	2	--	int¹		5		MN NS EA	600

HapMap Linkage Disequilibrium report for TXNL1 (54264439 - 54318831 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TXNL1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TXNL1

DNA2.0 Custom Variant and Variant Library Synthesis for TXNL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TXNL1 for disorders           About GeneDecksing

OMIM gene information: 603049    OMIM disorders: --

10 diseases for TXNL1:    About MalaCards

stomach cancer leukopenia alopecia alzheimer's disease

pneumonia tuberculosis malaria mycobacterium tuberculosis

pancreatic cancer pancreatitis

3 diseases from the University of Copenhagen DISEASES database for TXNL1:

Leukopenia Thymus adenocarcinoma Alopecia

Human Genome Epidemiology (HuGE) Navigator: TXNL1 (1 document)

Export disorders for TXNL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TXNL1 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with TXNL1)

Utopia: connect your pdf to the dynamic
world of online information

Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa. (PubMed id 9668102)^{1, 2, 3, 9} Lee K.-K.... Yonehara S. (1998)
Molecular cloning and expression of a cDNA encoding a human thioredoxin-like protein. (PubMed id 9473519)^{1, 2, 3, 9} Miranda-Vizuete A.... Spyrou G. (1998)
Genomic structure and chromosomal localization of human thioredoxin- like protein gene (txl). (PubMed id 10826702)^{1, 2, 9} Miranda-Vizuete A. and Spyrou G. (2000)
Thioredoxin Txnl1/TRP32 Is a Redox-active Cofactor of the 26 S Proteasome. (PubMed id 19349277)^{1, 2, 9} Andersen K.M....Hartmann-Petersen R. (2009)
Solution structure of the C-terminal DUF1000 domain o f the human thioredoxin-like 1 protein. (PubMed id 20455272)^{1, 2, 9} Goroncy A.K....Yokoyama S. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Crystal structure of the catalytic domain of a human thioredoxin-like protein. (PubMed id 11985582)^{1, 2} Jin J.... Yuan J. (2002)
Characterization of human thioredoxin-like-1: potential involvement in the cellular response against glucose deprivation. (PubMed id 16438969)^{1, 9} Jimenez A....Miranda-Vizuete A. (2006)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9352	HGNC: 12436	AceView: TXNL1	Ensembl:ENSG00000091164	euGenes: HUgn9352
ECgene: TXNL1	H-InvDB: TXNL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TXNL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TXNL1 gene
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Patent Information for TXNL1 gene:
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thioredoxin-like 1

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