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TXNL1 Gene

protein-coding   GIFtS: 55
GCID: GC18M054264

Thioredoxin-Like 1

(Previous names: thioredoxin-like, 32kDa)
(Previous symbol: TXNL)
  See TXNL1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin-Like 11 2     TXL-12
TXNL1 2 3 5     Txl2
32 KDa Thioredoxin-Related Protein2 3     Epididymis Secretory Protein Li 1142
TRP322 3     Thioredoxin-Like Protein 12
32kD1     Thioredoxin-Related 32 KDa Protein2
thioredoxin-like1     Thioredoxin-Related Protein 12
Thioredoxin-Like, 32kDa1     TXL3
HEL-S-1142     

External Ids:    HGNC: 124361   Entrez Gene: 93522   Ensembl: ENSG000000911647   OMIM: 6030495   UniProtKB: O433963   

Export aliases for TXNL1 gene to outside databases

Previous GC identifers: GC18M052420 GC18M052421 GC18M050981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TXNL1 Gene:
TXNL1 (thioredoxin-like 1) is a protein-coding gene. Diseases associated with TXNL1 include thymus adenocarcinoma. GO annotations related to this gene include disulfide oxidoreductase activity and electron carrier activity. An important paralog of this gene is TXNDC8.

UniProtKB/Swiss-Prot: TXNL1_HUMAN, O43396
Function: Active thioredoxin with a redox potential of about -250 mV

Gene Wiki entry for TXNL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TXNL1 gene promoter:
         AP-1   ATF-2   Meis-1b   AREB6   CREB   deltaCREB   PPAR-gamma2   c-Jun   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TXNL1 promoter sequence
   Search Chromatin IP Primers for TXNL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXNL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.31   Ensembl cytogenetic band:  18q21.31   HGNC cytogenetic band: 18q21.31

TXNL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNL1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M054264:  view genomic region     (about GC identifiers)

Start:
54,264,439 bp from pter      End:
54,318,831 bp from pter
Size:
54,393 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TXNL1_HUMAN, O43396 (See protein sequence)
Recommended Name: Thioredoxin-like protein 1  
Size: 289 amino acids; 32251 Da
Subunit: Component of the 19S regulatory cap of the 26S proteasome. Interacts with PSMD14/RPN11. Interacts with,
and reduces EEF1A1
2 PDB 3D structures from and Proteopedia for TXNL1:
1GH2 (3D)        1WWY (3D)    

Explore the universe of human proteins at neXtProt for TXNL1: NX_O43396

Explore proteomics data for TXNL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys5, Lys28, Lys102, Lys104, Lys181, Lys279
  • Modification sites at PhosphoSitePlus

  • See TXNL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004777.1  
    ENSEMBL proteins: 
     ENSP00000217515   ENSP00000464918   ENSP00000467317   ENSP00000466473   ENSP00000468165  
     ENSP00000466558   ENSP00000465606   ENSP00000440251  

    TXNL1 Human Recombinant Protein Products:

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    Novus Biologicals TXNL1 Proteins
    Novus Biologicals TXNL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TXNL1
    Cloud-Clone Corp. Proteins for TXNL1

     
    Search eBioscience for Proteins for TXNL1 

     
    antibodies-online proteins for TXNL1 (12 products) 

     
    antibodies-online peptides for TXNL1

    TXNL1 Antibody Products:

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    antibodies-online antibodies for TXNL1 (20 products) 

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    antibodies-online kits for TXNL1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR005746 Thioredoxin
     IPR012336 Thioredoxin-like_fold
     IPR008979 Galactose-bd-like
     IPR010400 PITH_dom
     IPR013766 Thioredoxin_domain

    Graphical View of Domain Structure for InterPro Entry O43396

    ProtoNet protein and cluster: O43396

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TXNL1_HUMAN, O43396
    Similarity: Contains 1 PITH domain
    Similarity: Contains 1 thioredoxin domain


    Find genes that share domains with TXNL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXNL1_HUMAN, O43396
    Function: Active thioredoxin with a redox potential of about -250 mV

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0015036disulfide oxidoreductase activity IDA9668102
         
    Find genes that share ontologies with TXNL1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TXNL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TXNL1:
    hsa-mir-16-5p (MIRT051069), hsa-mir-26a-5p (MIRT050179)

    Block miRNA regulation of human, mouse, rat TXNL1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TXNL1:
    hsa-miR-3139 hsa-miR-708 hsa-miR-199a-5p hsa-miR-182 hsa-miR-593 hsa-miR-199b-5p hsa-miR-3908 hsa-miR-28-5p
    SwitchGear 3'UTR luciferase reporter plasmidTXNL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TXNL1
    Predesigned siRNA for gene silencing in human, mouse, rat TXNL1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TXNL1 (NM_004786)
    Sino Biological Human cDNA Clone for TXNL1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNL1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for TXNL1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TXNL1_HUMAN, O43396: Cytoplasm. Nucleus. Note=At least 85% of the cellular TXNL1 is proteasome-associated
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with TXNL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TXNL1
    Interactions:

        Search GeneGlobe Interaction Network for TXNL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TXNL1 (O433963 ENSP000002175154) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    PSMD6Q150083, ENSP000002959014I2D: score=1 STRING: ENSP00000295901
    SH3BP4Q9P0V33, ENSP000003402374I2D: score=1 STRING: ENSP00000340237
    SUMO4Q6EEV63, ENSP000003186354I2D: score=1 STRING: ENSP00000318635
    USP14P545783, ENSP000002616014I2D: score=2 STRING: ENSP00000261601
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006662glycerol ether metabolic process IEA--
    GO:0045454cell redox homeostasis IEA--

    Find genes that share ontologies with TXNL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TXNL1

    1 Novoseek inferred chemical compound relationship for TXNL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 15.6 1 16438969 (1)



    Find genes that share compounds with TXNL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TXNL1 gene: 
    NM_004786.2  

    Unigene Cluster for TXNL1:

    Thioredoxin-like 1
    Hs.114412  [show with all ESTs]
    Unigene Representative Sequence: BX640857
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217515 ENST00000585497 ENST00000588615 ENST00000590954 ENST00000587807
    ENST00000589931 ENST00000586262 ENST00000587613 ENST00000589329 ENST00000589415
    ENST00000586079 ENST00000540155(uc010xdz.2 uc002lgg.3 uc002lgh.3 uc002lgi.3 uc002lgj.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat TXNL1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TXNL1:
    hsa-miR-3139 hsa-miR-708 hsa-miR-199a-5p hsa-miR-182 hsa-miR-593 hsa-miR-199b-5p hsa-miR-3908 hsa-miR-28-5p
    SwitchGear 3'UTR luciferase reporter plasmidTXNL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TXNL1
    Predesigned siRNA for gene silencing in human, mouse, rat TXNL1
    Clone
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    OriGene clones in human, mouse for TXNL1 (see all 7)
    OriGene ORF clones in mouse, rat for TXNL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TXNL1 (NM_004786)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNL1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TXNL1
    OriGene qSTAR qPCR primer pairs in human, mouse for TXNL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TXNL1
      QuantiTect SYBR Green Assays in human, mouse, rat TXNL1
      QuantiFast Probe-based Assays in human, mouse, rat TXNL1

    Additional mRNA sequence: 

    AB209263.1 AF003938.1 AF051896.1 AF052659.1 AK094926.1 AK313653.1 BC001156.1 BX640857.1 
    NR_024546.1 

    11 DOTS entries:

    DT.453897  DT.92407349  DT.91850846  DT.451926  DT.95188792  DT.75157992  DT.40221703  DT.92440791 
    DT.95188791  DT.100644040  DT.92326962 

    Selected AceView cDNA sequences (see all 320):

    AI291452 AA600928 AA913646 BF195548 BQ636798 BU195211 AA913184 CA448600 
    CD365235 BM741325 CA442270 CA309895 AA705311 AI590701 BX111174 BE393793 
    AA743739 BM552668 AA923115 C00325 BQ229551 AI339963 BI822409 BM551063 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TXNL1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                                                              -                                         -         
    SP2:                                                              -                                                   
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                    -                                                                                             


    ECgene alternative splicing isoforms for TXNL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TXNL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATTGTAAA
    TXNL1 Expression
    About this image


    TXNL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    TXNL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TXNL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.114412

    UniProtKB/Swiss-Prot: TXNL1_HUMAN, O43396
    Tissue specificity: Ubiquitous

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    QuantiFast Probe-based Assays in human, mouse, rat TXNL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TXNL1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txnl11 , 5 thioredoxin-like 11, 5 92.73(n)1
    98.62(a)1
      18 (37.06 cM)5
    533821  NM_016792.41  NP_058072.21 
     636628015 
    chicken
    (Gallus gallus)
    Aves TXNL11 thioredoxin-like 1 85.01(n)
    91.7(a)
      426854  XM_424463.4  XP_424463.1 
    lizard
    (Anolis carolinensis)
    Reptilia TXNL16
    thioredoxin-like 1
    92(a)
    1 ↔ 1
    GL343213.1(1436858-1458601)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA981215.12   -- 78.07(n)    CA981215.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc553682 similar to thioredoxin-like, 32kDa 75.85(n)   394113  BC045322.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Txl1 Thioredoxin-like 53.77(n)
    49.83(a)
      38646  NM_079214.4  NP_523938.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E10A.31 Y54E10A.3 53.02(n)
    46.01(a)
      171897  NM_058726.4  NP_491127.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TRX16
    TRX26
    (see all 3)
    Cytoplasmic thioredoxin isoenzyme of the thioredox...
    Cytoplasmic thioredoxin isoenzyme of the thioredox...
    (see all 3)
    32(a)
    27(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XII(231702-232013) YLR043C
    VII(912913-913227) YGR209C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G047801 AT3G04780 53.09(n)
    45.68(a)
      819638  NM_111350.2  NP_566238.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07955001 Os03g0795500 51.28(n)
    40.83(a)
      4334415  NM_001058084.1  NP_001051549.1 


    ENSEMBL Gene Tree for TXNL1 (if available)
    TreeFam Gene Tree for TXNL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TXNL1 gene
    TXNDC82  TXN2  TXNDC22  
    2 SIMAP similar genes for TXNL1 using alignment to 7 protein entries:     TXNL1_HUMAN (see all proteins):
    TXNDC8    TXN

    Find genes that share paralogs with TXNL1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TXNL1
    PGOHUM00000248656


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TXNL1 (see all 779)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs743466651,2
    C,F--54269581(+) TTTCCC/TCAACT 2 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1812312731,2
    --54269852(+) TTAGCC/TGTTCC 2 -- ds50010--------
    rs1461758271,2
    C--54269903(+) ATGTA-/CTTCTTAA 2 -- ds50010--------
    rs1409750051,2
    --54269994(+) AATCAG/TAAGTT 2 -- ds50010--------
    rs1862550051,2
    --54270002(+) GTTAAC/TCAGTT 2 -- ds50010--------
    rs6619811,2
    C,F,A,H--54270044(-) TTGTCA/TTTCTA 2 -- ds500121Minor allele frequency- T:0.07MN NA NS EA WA CSA 1114
    rs1449351011,2
    C--54270052(+) CAAAAA/GTTAAG 2 -- ds50010--------
    rs18019471,2
    C--54270088(-) CATGCA/G/TTTGTA 4 -- ut31 nc-transcript-variant0--------
    rs774718881,2
    C,F--54270111(+) CAATGG/AAAACA 2 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.01NA 120
    rs1995237451,2
    C--54270254(+) TTTTGT/CACCTT 2 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.00EU 1323

    HapMap Linkage Disequilibrium report for TXNL1 (54264439 - 54318831 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TXNL1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TXNL1
    DNA2.0 Custom Variant and Variant Library Synthesis for TXNL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603049    OMIM disorders: --

    1 disease for TXNL1:    
    About MalaCards
    thymus adenocarcinoma

    3 diseases from the University of Copenhagen DISEASES database for TXNL1:
    Leukopenia     Thymus adenocarcinoma     Alopecia

    Find genes that share disorders with TXNL1           About GenesLikeMe

    Genetic Association Database (GAD): TXNL1
    Human Genome Epidemiology (HuGE) Navigator: TXNL1 (1 document)

    Export disorders for TXNL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TXNL1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with TXNL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa. (PubMed id 9668102)1, 2, 3, 9 Lee K.-K.... Yonehara S. (J. Biol. Chem. 1998)
    2. Molecular cloning and expression of a cDNA encoding a human thioredoxin-like protein. (PubMed id 9473519)1, 2, 3, 9 Miranda-Vizuete A.... Spyrou G. (Biochem. Biophys. Res. Commun. 1998)
    3. Genomic structure and chromosomal localization of human thioredoxin- like protein gene (txl). (PubMed id 10826702)1, 2, 9 Miranda-Vizuete A. and Spyrou G. (DNA Seq. 2000)
    4. Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome. (PubMed id 19349277)1, 2, 9 Andersen K.M.... Hartmann-Petersen R. (J. Biol. Chem. 2009)
    5. Solution structure of the C-terminal DUF1000 domain of the human thioredoxin-like 1 protein. (PubMed id 20455272)1, 2, 9 Goroncy A.K.... Yokoyama S. (Proteins 2010)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    9. Crystal structure of the catalytic domain of a human thioredoxin-like protein. (PubMed id 11985582)1, 2 Jin J.... Yuan J. (Eur. J. Biochem. 2002)
    10. Characterization of human thioredoxin-like-1: potential involvement in the cellular response against glucose deprivation. (PubMed id 16438969)1, 9 JimAcnez A....Miranda-Vizuete A. (FEBS Lett. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9352 HGNC: 12436 AceView: TXNL1 Ensembl:ENSG00000091164 euGenes: HUgn9352
    ECgene: TXNL1 H-InvDB: TXNL1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TXNL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TXNL1 gene:
    Search GeneIP for patents involving TXNL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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