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Aliases for TXNIP Gene

Aliases for TXNIP Gene

  • Thioredoxin Interacting Protein 2 3
  • Upregulated By 1,25-Dihydroxyvitamin D-3 2 3
  • Vitamin D3 Up-Regulated Protein 1 3 4
  • Thioredoxin Binding Protein 2 2 3
  • Thioredoxin-Binding Protein 2 3 4
  • VDUP1 3 4
  • EST01027 3
  • HHCPA78 3
  • THIF 3

External Ids for TXNIP Gene

Previous GeneCards Identifiers for TXNIP Gene

  • GC01P143959
  • GC01P142025
  • GC01P143165
  • GC01P143187
  • GC01P142927
  • GC01P144149
  • GC01P145438
  • GC01P119402

Summaries for TXNIP Gene

Entrez Gene Summary for TXNIP Gene

  • This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for TXNIP Gene

TXNIP (Thioredoxin Interacting Protein) is a Protein Coding gene. Among its related pathways are Immune System and Glucose / Energy Metabolism. GO annotations related to this gene include ubiquitin protein ligase binding and enzyme inhibitor activity.

UniProtKB/Swiss-Prot for TXNIP Gene

  • May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Gene Wiki entry for TXNIP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNIP Gene

Genomics for TXNIP Gene

Regulatory Elements for TXNIP Gene

Genomic Location for TXNIP Gene

Chromosome:
1
Start:
145,992,435 bp from pter
End:
145,996,631 bp from pter
Size:
4,197 bases
Orientation:
Minus strand

Genomic View for TXNIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXNIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNIP Gene

Proteins for TXNIP Gene

  • Protein details for TXNIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3M7-TXNIP_HUMAN
    Recommended name:
    Thioredoxin-interacting protein
    Protein Accession:
    Q9H3M7
    Secondary Accessions:
    • B4E3D3
    • Q16226
    • Q6PML0
    • Q9BXG9

    Protein attributes for TXNIP Gene

    Size:
    391 amino acids
    Molecular mass:
    43661 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.

    Three dimensional structures from OCA and Proteopedia for TXNIP Gene

    Alternative splice isoforms for TXNIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TXNIP Gene

Proteomics data for TXNIP Gene at MOPED

Post-translational modifications for TXNIP Gene

  • Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
  • Ubiquitination at Lys 26, Lys 212, Lys 228, Lys 233, and Lys 287
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNIP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TXNIP (TXNIP)

No data available for DME Specific Peptides for TXNIP Gene

Domains & Families for TXNIP Gene

Protein Domains for TXNIP Gene

Suggested Antigen Peptide Sequences for TXNIP Gene

Graphical View of Domain Structure for InterPro Entry

Q9H3M7

UniProtKB/Swiss-Prot:

TXNIP_HUMAN :
  • Belongs to the arrestin family.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with TXNIP: view

No data available for Gene Families for TXNIP Gene

Function for TXNIP Gene

Molecular function for TXNIP Gene

UniProtKB/Swiss-Prot Function:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
UniProtKB/Swiss-Prot Induction:
By 1,25-dihydroxyvitamin D-3 and TGFB1. Down-regulated in response to oxidative stress.

Gene Ontology (GO) - Molecular Function for TXNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
GO:0005515 protein binding IPI 14632196
GO:0031625 ubiquitin protein ligase binding IPI 20068034
genes like me logo Genes that share ontologies with TXNIP: view
genes like me logo Genes that share phenotypes with TXNIP: view

Animal Models for TXNIP Gene

MGI Knock Outs for TXNIP:

Animal Model Products

miRNA for TXNIP Gene

miRTarBase miRNAs that target TXNIP

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXNIP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TXNIP Gene

Localization for TXNIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNIP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXNIP Gene COMPARTMENTS Subcellular localization image for TXNIP gene
Compartment Confidence
cytosol 4
plasma membrane 3
endoplasmic reticulum 2
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TXNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 14632196
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TXNIP: view

Pathways & Interactions for TXNIP Gene

genes like me logo Genes that share pathways with TXNIP: view

Pathways by source for TXNIP Gene

PCR Array Products

Interacting Proteins for TXNIP Gene

Gene Ontology (GO) - Biological Process for TXNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006606 protein import into nucleus IEA --
GO:0006979 response to oxidative stress --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with TXNIP: view

No data available for SIGNOR curated interactions for TXNIP Gene

Drugs & Compounds for TXNIP Gene

(2) Drugs for TXNIP Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholesterol Experimental Pharma Agonist 0
SB 203580 Pharma P38 MAP kinase inhibitor, Selective inhibitor of p38 MAPK 0

(6) Additional Compounds for TXNIP Gene - From: NovoSeek

genes like me logo Genes that share compounds with TXNIP: view

Transcripts for TXNIP Gene

mRNA/cDNA for TXNIP Gene

Unigene Clusters for TXNIP Gene

Thioredoxin interacting protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXNIP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNIP Gene

No ASD Table

Relevant External Links for TXNIP Gene

GeneLoc Exon Structure for
TXNIP
ECgene alternative splicing isoforms for
TXNIP

Expression for TXNIP Gene

mRNA expression in normal human tissues for TXNIP Gene

Protein differential expression in normal tissues from HIPED for TXNIP Gene

This gene is overexpressed in Breast (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TXNIP Gene



SOURCE GeneReport for Unigene cluster for TXNIP Gene Hs.709057

genes like me logo Genes that share expression patterns with TXNIP: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TXNIP Gene

Orthologs for TXNIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TXNIP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TXNIP 35
  • 91.13 (n)
  • 94.88 (a)
dog
(Canis familiaris)
Mammalia TXNIP 35
  • 91.22 (n)
  • 97.44 (a)
mouse
(Mus musculus)
Mammalia Txnip 35
  • 89.2 (n)
  • 96.4 (a)
Txnip 16
chimpanzee
(Pan troglodytes)
Mammalia TXNIP 35
  • 99.66 (n)
  • 99.23 (a)
rat
(Rattus norvegicus)
Mammalia Txnip 35
  • 89.37 (n)
  • 97.17 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia txnip 35
  • 73.35 (n)
  • 77.57 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.27568 35
zebrafish
(Danio rerio)
Actinopterygii txnip 35
txnipa 35
  • 64.29 (n)
  • 61.9 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4823 35
Species with no ortholog for TXNIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNIP Gene

ENSEMBL:
Gene Tree for TXNIP (if available)
TreeFam:
Gene Tree for TXNIP (if available)

Paralogs for TXNIP Gene

(3) SIMAP similar genes for TXNIP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TXNIP: view

No data available for Paralogs for TXNIP Gene

Variants for TXNIP Gene

Sequence variations from dbSNP and Humsavar for TXNIP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4755 -- 145,992,806(-) CTGTG(A/G/T)TCAGA utr-variant-3-prime
rs7211 -- 145,993,449(-) ACTTA(A/C/T)GTATC utr-variant-3-prime
rs7212 -- 145,992,816(-) ATGCC(C/G)AACCC utr-variant-3-prime
rs9245 -- 145,996,488(-) GACTT(A/C)GCTTA utr-variant-5-prime
rs833392 -- 145,996,491(-) TCTGA(A/C)TTCGC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TXNIP Gene

Variant ID Type Subtype PubMed ID
nsv428212 CNV Gain 18775914
dgv104e1 CNV Complex 17122850
nsv7181 OTHER Inversion 18451855
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
nsv509457 CNV Insertion 20534489
dgv105e1 CNV Complex 17122850
dgv111e1 CNV Complex 17122850
esv2422428 CNV Duplication 17116639
nsv831359 CNV Loss 17160897
dgv112e1 CNV Complex 17122850
dgv346n71 CNV Gain 21882294
dgv347n71 CNV Gain 21882294
nsv831370 CNV Gain 17160897

Variation tolerance for TXNIP Gene

Residual Variation Intolerance Score: 25.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNIP Gene

HapMap Linkage Disequilibrium report
TXNIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNIP Gene

Disorders for TXNIP Gene

Relevant External Links for TXNIP

Genetic Association Database (GAD)
TXNIP
Human Genome Epidemiology (HuGE) Navigator
TXNIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXNIP
genes like me logo Genes that share disorders with TXNIP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNIP Gene

Publications for TXNIP Gene

  1. Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3. (PMID: 8086474) Chen K.-S. … DeLuca H.F. (Biochim. Biophys. Acta 1994) 2 23 67
  2. Decreasing Txnip mRNA and protein levels in pancreatic MIN6 cells reduces reactive oxygen species and restores glucose regulated insulin secretion. (PMID: 20511712) Rani S. … O'Driscoll L. (Cell. Physiol. Biochem. 2010) 23 67
  3. The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. (PMID: 20068034) Zhang P. … Yu L. (J. Biol. Chem. 2010) 23 67
  4. Hedgehog-dependent down-regulation of the tumor suppressor, vitamin D3 up-regulated protein 1 (VDUP1), precedes lamina development in Drosophila. (PMID: 20138028) Chang S. … Dearborn R.E. (Brain Res. 2010) 23 67
  5. The roles of thioredoxin and thioredoxin-binding protein-2 in endometriosis. (PMID: 20172870) Seo S.K. … Lee B.S. (Hum. Reprod. 2010) 23 67

Products for TXNIP Gene

Sources for TXNIP Gene

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