Aliases for TXNIP Gene
External Ids for TXNIP Gene
Previous GeneCards Identifiers for TXNIP Gene
GeneCards Summary for TXNIP Gene
TXNIP (Thioredoxin Interacting Protein) is a Protein Coding gene. Diseases associated with TXNIP include hyperglycemia. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. GO annotations related to this gene include ubiquitin protein ligase binding and enzyme inhibitor activity.
UniProtKB/Swiss-Prot for TXNIP Gene
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).