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TXNIP Gene

protein-coding   GIFtS: 57
GCID: GC01P145438

Thioredoxin Interacting Protein

  See TXNIP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin Interacting Protein1 2     Upregulated By 11
VDUP12 3 5     EST010272
Thioredoxin Binding Protein 21 2     HHCPA782
Thioredoxin-Binding Protein 22 3     THIF2
Vitamin D3 Up-Regulated Protein 12 3     Thioredoxin-Interacting Protein2
25-Dihydroxyvitamin D-31     Upregulated By 1,25-Dihydroxyvitamin D-32

External Ids:    HGNC: 169521   Entrez Gene: 106282   Ensembl: ENSG000001172897   OMIM: 6065995   UniProtKB: Q9H3M73   

Export aliases for TXNIP gene to outside databases

Previous GC identifers: GC01P143959 GC01P142025 GC01P143165 GC01P143187 GC01P142927 GC01P144149 GC01P119402


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TXNIP Gene:
TXNIP (thioredoxin interacting protein) is a protein-coding gene. Diseases associated with TXNIP include hyperglycemia. GO annotations related to this gene include enzyme inhibitor activity and ubiquitin protein ligase binding. An important paralog of this gene is ARRDC1.

UniProtKB/Swiss-Prot: TXNIP_HUMAN, Q9H3M7
Function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its
bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the
COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional
repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and
over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as
a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the
inhibition of the mammalian target of rapamycin complex 1 (mTORC1)

Gene Wiki entry for TXNIP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TXNIP gene promoter:
         PPAR-gamma1   p53   AP-1   ATF-2   ZIC2/Zic2   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXNIP promoter sequence
   Search Chromatin IP Primers for TXNIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXNIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q11

TXNIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNIP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P145438:  view genomic region     (about GC identifiers)

Start:
145,438,462 bp from pter      End:
145,442,635 bp from pter
Size:
4,174 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TXNIP_HUMAN, Q9H3M7 (See protein sequence)
Recommended Name: Thioredoxin-interacting protein  
Size: 391 amino acids; 43661 Da
Subunit: Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with
transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains).
Interacts with DDIT4
2 PDB 3D structures from and Proteopedia for TXNIP:
4GEI (3D)        4GEJ (3D)    
Secondary accessions: Q16226 Q6PML0 Q9BXG9

Explore the universe of human proteins at neXtProt for TXNIP: NX_Q9H3M7

Explore proteomics data for TXNIP at MOPED

Post-translational modifications: 

  • Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation1
  • Ubiquitination2 at Lys26, Lys212, Lys228, Lys233, Lys287
  • Modification sites at PhosphoSitePlus

  • See TXNIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006463.3  
    ENSEMBL proteins: 
     ENSP00000358323   ENSP00000396322  
    Reactome Protein details: Q9H3M7

    TXNIP Human Recombinant Protein Products:

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    Novus Biologicals TXNIP Protein
    Novus Biologicals TXNIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TXNIP 

     
    antibodies-online proteins for TXNIP (4 products) 

     
    antibodies-online peptides for TXNIP

    TXNIP Antibody Products:

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    antibodies-online antibodies for TXNIP (41 products) 

    TXNIP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for TXNIP 
    antibodies-online kits for TXNIP (26 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR011022 Arrestin_C-like
     IPR011021 Arrestin-like_N

    Graphical View of Domain Structure for InterPro Entry Q9H3M7

    ProtoNet protein and cluster: Q9H3M7

    UniProtKB/Swiss-Prot: TXNIP_HUMAN, Q9H3M7
    Similarity: Belongs to the arrestin family


    Find genes that share domains with TXNIP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXNIP_HUMAN, Q9H3M7
    Function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its
    bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the
    COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional
    repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and
    over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as
    a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the
    inhibition of the mammalian target of rapamycin complex 1 (mTORC1)
    Induction: By 1,25-dihydroxyvitamin D-3 and TGFB1. Down-regulated in response to oxidative stress

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity IEA--
    GO:0005515protein binding IPI14632196
    GO:0031625ubiquitin protein ligase binding IPI--
         
    Find genes that share ontologies with TXNIP           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TXNIP:
     G0/1 arrest  Increased G1 DNA content 

         14 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Txnip):
     cardiovascular system  cellular  digestive/alimentary  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     normal  renal/urinary system  reproductive system  tumorigenesis 

    Find genes that share phenotypes with TXNIP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TXNIP: Txniptm1Jjy Txniptm1.1Road Txniptm1.1Rlee Txniptm1Yu

       genOway: Develop your customized and physiologically relevant rodent model for TXNIP

    miRNA
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    miRTarBase miRNAs that target TXNIP:
    hsa-mir-373-3p (MIRT005561), hsa-mir-34a-5p (MIRT025554), hsa-mir-148b-3p (MIRT019486), hsa-mir-183-5p (MIRT025014), hsa-mir-128-3p (MIRT022063), hsa-mir-378a-3p (MIRT043886)

    Block miRNA regulation of human, mouse, rat TXNIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TXNIP (see all 54):
    hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-301a hsa-miR-424 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTXNIP 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TXNIP
    Predesigned siRNA for gene silencing in human, mouse, rat TXNIP

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TXNIP

    Clone
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    OriGene clones in human, mouse for TXNIP (see all 7)
    OriGene ORF clones in mouse, rat for TXNIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TXNIP (NM_006472)
    Sino Biological Human cDNA Clone for TXNIP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNIP

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TXNIP_HUMAN, Q9H3M7: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus2
    endoplasmic reticulum1
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA14632196
    GO:0005758mitochondrial intermembrane space IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with TXNIP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TXNIP About    
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    Inflammasomes0.00


    Find genes that share SuperPaths with TXNIP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TXNIP
        The NLRP3 inflammasome


        Pathway & Disease-focused RT2 Profiler PCR Arrays including TXNIP (see all 9): 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TXNIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for TXNIP (Q9H3M72, 3 ENSP000003583234) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FHL1Q136422, 3, ENSP000003597244MINT-8255437 I2D: score=2 STRING: ENSP00000359724
    SMURF2Q9HAU42, 3MINT-61794 I2D: score=3 
    TXNP105993, ENSP000003636414I2D: score=6 STRING: ENSP00000363641
    NLRP3Q96P203, ENSP000003373834I2D: score=1 STRING: ENSP00000337383
    HDAC1Q135473, ENSP000003626494I2D: score=3 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006606protein import into nucleus IEA--
    GO:0006979response to oxidative stress ----
    GO:0007049cell cycle IEA--

    Find genes that share ontologies with TXNIP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TXNIP

    8 Novoseek inferred chemical compound relationships for TXNIP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1,25 dihydroxy vitamin d3 54.2 15 8086474 (4), 16061374 (4), 11234883 (1), 11126200 (1) (see all 6)
    glucose 47.3 132 19052253 (8), 17555594 (6), 15705778 (5), 19706488 (5) (see all 21)
    oxygen 23.3 12 20511712 (2), 17575238 (1), 15474995 (1), 19327827 (1) (see all 6)
    sb 203580 22.6 3 11579135 (1), 17555594 (1)
    n acetylcysteine 20 2 15474995 (1), 12386145 (1)
    lipid 16.4 6 19619006 (2), 16269462 (1), 20068034 (1), 17697931 (1)
    cholesterol 0 1 12213820 (1)
    h2o2 0 1 12386145 (1)



    Find genes that share compounds with TXNIP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TXNIP gene: 
    NM_006472.4  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369317(uc001enn.4 uc010oys.2) ENST00000475171 ENST00000425134
    ENST00000488537 ENST00000486597
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TXNIP (see all 54):
    hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-301a hsa-miR-424 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTXNIP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TXNIP
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    GenScript: all cDNA clones in your preferred vector: TXNIP (NM_006472)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNIP
    Primer
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    OriGene qPCR primer pairs and template standards for TXNIP
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TXNIP
      QuantiTect SYBR Green Assays in human, mouse, rat TXNIP
      QuantiFast Probe-based Assays in human, mouse, rat TXNIP

    Selected AceView cDNA sequences (see all 1926):

    BG036146 AA805348 AA329795 BF432243 CD106966 BU661530 AA036815 T32905 
    BM786538 AA383291 AI289915 T32688 BM565582 BF724841 AA135352 BQ050710 
    AI699231 F24377 BI495860 BQ029953 CA975878 BP366678 AA973699 AI273701 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TXNIP    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:        -                                                     -                           
    SP2:                                                                                          
    SP3:                                                              -                           
    SP4:                                                              -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for TXNIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TXNIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTGTATT
    TXNIP Expression
    About this image


    TXNIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primary Follicle
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Kidney (Urinary System)
             Metanephros
    TXNIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TXNIP Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TXNIP (see all 9): 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TXNIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TXNIP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txnip1 , 5 thioredoxin interacting protein1, 5 89.2(n)1
    96.4(a)1
      3 (41.93 cM)5
    563381  NM_023719.21  NP_076208.21 
     965579575 
    lizard
    (Anolis carolinensis)
    Reptilia TXNIP6
    thioredoxin interacting protein
    73(a)
    1 ↔ 1
    AAWZ02041877(2101-4231)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.275682 Xenopus laevis transcribed sequence with moderate similarity more 77.22(n)    CF282848.1 
    zebrafish
    (Danio rerio)
    Actinopterygii txnip2 thioredoxin interacting protein 77.48(n)   368359  BC049493.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vdup16
    Vitamin D[[3]] up-regulated protein 1
    22(a)
    1 → many
    3L(176306-178963)
    worm
    (Caenorhabditis elegans)
    Secernentea arrd-166
    arrd-126
    (see all 3)
    Protein ARRD-12 (arrd-12) mRNA, complete cds
    (see all 3)
    22(a)
    21(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(12484732-12488343) WBGene00013043
    II(13766318-13768403) WBGene00011053


    ENSEMBL Gene Tree for TXNIP (if available)
    TreeFam Gene Tree for TXNIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TXNIP gene
    ARRDC12  ARRDC32  ARRDC22  ARRDC42  
    3 SIMAP similar genes for TXNIP using alignment to 4 protein entries:     TXNIP_HUMAN (see all proteins):
    ARRDC4    ARRDC3    ARRDC2

    Find genes that share paralogs with TXNIP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for TXNIP    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38320031,2
    C--145441841(+) TGCTT-/AAGAGT 1 -- ut312Minor allele frequency- A:0.25NA CSA 4
    rs66747731,2,4
    ----see VAR_0483342 mis40--------

    HapMap Linkage Disequilibrium report for TXNIP (145438462 - 145442635 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TXNIP (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv15n16CNV Deletion17901297
    dgv46e201CNV Deletion23290073
    esv2422428CNV Duplication17116639
    nsv509457CNV Insertion20534489
    nsv831359CNV Loss17160897
    nsv428212CNV Gain18775914
    dgv346n71CNV Gain21882294
    dgv347n71CNV Gain21882294
    nsv831370CNV Gain17160897
    dgv111e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TXNIP
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606599    OMIM disorders: --

    1 disease for TXNIP:    
    About MalaCards
    hyperglycemia

    2 diseases from the University of Copenhagen DISEASES database for TXNIP:
    Diabetes mellitus     Hyperglycemia

    Find genes that share disorders with TXNIP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TXNIP gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperlipidemia familial combined 61.5 2 15136067 (1), 15368498 (1)
    hyperglycemia 45.7 12 15128745 (3), 17575238 (2), 17555594 (2), 15687841 (1) (see all 5)
    nonmetastatic 31.2 5 17575238 (1)
    tumors 25.6 34 12821938 (3), 20138028 (2), 15930262 (2), 18062927 (2) (see all 18)
    cancer 17.8 15 19773351 (2), 17034356 (1), 17671698 (1), 19351825 (1) (see all 12)
    niddm 14.1 3 17381501 (1), 20075245 (1)
    cardiovascular diseases 2.67 1 17172268 (1)
    shock 0 4 14766217 (3), 17675577 (1)
    breast cancer 0 3 12744759 (1), 15345672 (1), 11126200 (1)
    metastasis 0 8 12543799 (4), 12744759 (1), 18062927 (1), 20068034 (1)

    Genetic Association Database (GAD): TXNIP
    Human Genome Epidemiology (HuGE) Navigator: TXNIP (5 documents)

    Export disorders for TXNIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TXNIP gene, integrated from 10 sources (see all 182):
    (articles sorted by number of sources associating them with TXNIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3. (PubMed id 8086474)1, 2, 3, 9 Chen K.-S. and DeLuca H.F. (Biochim. Biophys. Acta 1994)
    2. The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. (PubMed id 20068034)1, 2, 9 Zhang P.... Yu L. (J. Biol. Chem. 2010)
    3. VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. (PubMed id 12821938)1, 2, 9 Han S.H.... Choi I. (Oncogene 2003)
    4. hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip. (PubMed id 18541147)1, 2, 9 Shin K.H.... Park N.H. (Biochem. Biophys. Res. Commun. 2008)
    5. Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus. (PubMed id 17381501)1, 4, 9 van Greevenbroek M.M....de Bruin T.W. (Diabet. Med. 2007)
    6. Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2). (PubMed id 17603038)1, 2, 9 Liyanage N.P.M.... Lou M.F. (Exp. Eye Res. 2007)
    7. Structure of the N-terminal domain of human thioredoxin-interacting protein. (PubMed id 23519408)1, 2 Polekhina G....Waltham M. (Acta Crystallogr. D Biol. Crystallogr. 2013)
    8. TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1. (PubMed id 21460850)1, 2 Jin H.O.... Park I.C. (Oncogene 2011)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Gender differences in genetic risk profiles for cardiovascular disease. (PubMed id 18974842)1, 4 Silander K....Peltonen L. (PLoS ONE 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10628 HGNC: 16952 AceView: TXNIP Ensembl:ENSG00000117289 euGenes: HUgn10628
    ECgene: TXNIP H-InvDB: TXNIP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TXNIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TXNIP gene:
    Search GeneIP for patents involving TXNIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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