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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TXNIP Gene

protein-coding   GIFtS: 57
GCID: GC01P145438

thioredoxin interacting protein
 Explore 33 diseases affiliated with
TXNIP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TXNIP    

Aliases
for TXNIP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Thioredoxin Interacting Protein1 2     Thioredoxin-Binding Protein 22 3
VDUP11 2 3 5     Vitamin D3 Up-Regulated Protein 12 3
EST010271 2     Thioredoxin Binding Protein 22
HHCPA781 2     Thioredoxin-Interacting Protein2
THIF1 2     Upregulated By 1,25-Dihydroxyvitamin D-32

External Ids:    HGNC: 169521   Entrez Gene: 106282   Ensembl: ENSG000001172897   OMIM: 6065995   UniProtKB: Q9H3M73   

Export aliases for TXNIP gene to outside databases

Previous GC identifers: GC01P143959 GC01P142025 GC01P143165 GC01P143187 GC01P142927 GC01P144149 GC01P119402


Summaries
for TXNIP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TXNIP_HUMAN, Q9H3M7
Function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its
bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the
COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor,
possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression
will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of
tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the
mammalian target of rapamycin complex 1 (mTORC1)

Gene Wiki entry for TXNIP


Genomic Views
for TXNIP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167185.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TXNIP gene promoter:
         PPAR-gamma1   p53   AP-1   ATF-2   ZIC2/Zic2   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TXNIP promoter sequence
   Search SABiosciences Chromatin IP Primers for TXNIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q11

TXNIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNIP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P145438:  view genomic region     (about GC identifiers)

Start:
 145,438,462 bp from pter      End:
 145,442,635 bp from pter
Size:
 4,174 bases      Orientation:
 plus strand

Proteins
for TXNIP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TXNIP_HUMAN, Q9H3M7 (See protein sequence)
Recommended Name: Thioredoxin-interacting protein  
Size: 391 amino acids; 43661 Da
Subunit: Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors
ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q16226 Q6PML0 Q9BXG9

Explore the universe of human proteins at neXtProt for TXNIP: NX_Q9H3M7

Post-translational modifications:

  • Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H3M7

    • TXNIP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006463.3  
    ENSEMBL proteins: 
     ENSP00000358323   ENSP00000396322  
    Reactome Protein details: Q9H3M7
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: TXNIP
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    OriGene Custom Protein Services for TXNIP 
    GenScript Custom Purified and Recombinant Proteins Services for TXNIP
    Novus Biologicals TXNIP Protein
    Novus Biologicals TXNIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA14632196
    GO:0005758mitochondrial intermembrane space IEA--
    GO:0005829cytosol TAS--


    TXNIP for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for TXNIP

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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for TXNIP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TXNIP for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR014756 Ig_E-set
     IPR011022 Arrestin_C-like
     IPR011021 Arrestin-like_N

    Graphical View of Domain Structure for InterPro Entry Q9H3M7

    ProtoNet protein and cluster: Q9H3M7

    UniProtKB/Swiss-Prot: TXNIP_HUMAN, Q9H3M7
    Similarity: Belongs to the arrestin family


    Function
    for TXNIP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TXNIP_HUMAN, Q9H3M7
    Function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its
    bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the
    COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor,
    possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression
    will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of
    tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the
    mammalian target of rapamycin complex 1 (mTORC1)
    Induction: By 1,25-dihydroxyvitamin D-3 and TGFB1. Down-regulated in response to oxidative stress

    miRNA
    Products:            		miRTarBase miRNAs that target TXNIP:
    hsa-mir-373 (MIRT005561)

    OriGene 3'-UTR Clone: TXNIP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNIP
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNIP (see all 54):
    hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-301a hsa-miR-424 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: TXNIP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TXNIP (see all 7)
    OriGene shRNA RFP: TXNIP
    OriGene siRNA: TXNIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNIP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TXNIP

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNIP (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNIP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TXNIP (NM_006472)
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    Cell Line
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    Search LifeMap BioReagents cell lines for TXNIP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNIP

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity IEA--
    GO:0005515protein binding IPI14632196
    GO:0031625ubiquitin protein ligase binding IPI--


    TXNIP for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TXNIP:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         Mouse knock-outs for TXNIP: Txniptm1Jjy Txniptm1.1Road Txniptm1.1Rlee Txniptm1Yu
         14 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Txnip):
     cardiovascular system  cellular  digestive/alimentary  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     normal  renal/urinary system  reproductive system  tumorigenesis 

    TXNIP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TXNIP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Inflammasomes
    		Inflammasomes1.00
    		The NLRP3 inflammasome0.71
    2Immune System
    		Immune System1.00
    		Innate Immune System0.46
    3Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    		Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for TXNIP
        The NLRP3 inflammasome
    Inflammasomes
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Immune System
    Innate Immune System



    TXNIP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TXNIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/15 Interacting proteins for TXNIP (Q9H3M72, 3 ENSP000003583234) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FHL1Q136422, 3, ENSP000003597244MINT-8255437 I2D: score=2 STRING: ENSP00000359724
    SMURF2Q9HAU42, 3MINT-61794 I2D: score=3 
    TXNP105993, ENSP000003636414I2D: score=6 STRING: ENSP00000363641
    NLRP3Q96P203, ENSP000003373834I2D: score=1 STRING: ENSP00000337383
    HDAC1Q135473, ENSP000003626494I2D: score=3 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006606protein import into nucleus IEA--
    GO:0006979response to oxidative stress ----


    TXNIP for ontologies           About GeneDecksing



    Drugs & Compounds
    for TXNIP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TXNIP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TXNIP
    8 Novoseek chemical compound relationships for TXNIP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1,25 dihydroxy vitamin d3 54.2 15 8086474 (4), 16061374 (4), 11234883 (1), 11126200 (1) (see all 6)
    glucose 47.3 132 19052253 (8), 17555594 (6), 15705778 (5), 19706488 (5) (see all 21)
    oxygen 23.3 12 20511712 (2), 17575238 (1), 15474995 (1), 19327827 (1) (see all 6)
    sb 203580 22.6 3 11579135 (1), 17555594 (1)
    n acetylcysteine 20 2 15474995 (1), 12386145 (1)
    lipid 16.4 6 19619006 (2), 16269462 (1), 20068034 (1), 17697931 (1)
    cholesterol 0 1 12213820 (1)
    h2o2 0 1 12386145 (1)

    Search CenterWatch for drugs/clinical trials and news about TXNIP 

    Transcripts
    for TXNIP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TXNIP gene: 
    NM_006472.3  

    Unigene Cluster for TXNIP:

    Thioredoxin interacting protein
    Hs.709057  [show with all ESTs]
    Unigene Representative Sequence: NM_006472
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369317(uc001enn.4 uc010oys.2) ENST00000475171 ENST00000425134
    ENST00000488537 ENST00000486597

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TXNIP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNIP
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNIP (see all 54):
    hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-301a hsa-miR-424 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: TXNIP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TXNIP (see all 7)
    OriGene shRNA RFP: TXNIP
    OriGene siRNA: TXNIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNIP
    Clone
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    GenScript: all cDNA clones in your preferred vector: TXNIP (NM_006472)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNIP

    Additional cDNA sequence: 

    AK226090.1 AK301148.1 AK301203.1 AK304670.1 AY594328.2 BC024305.1 BC093702.1 BC093704.1 
    BX537824.1 S73591.1 

    24/61 DOTS entries (see all 61):

    DT.450617  DT.100857481  DT.95125683  DT.100702005  DT.121328945  DT.100858787  DT.100702003  DT.100856796 
    DT.100701988  DT.121328905  DT.121328932  DT.100702019  DT.100639149  DT.100855066  DT.92466452  DT.95125684 
    DT.100686539  DT.92466479  DT.100702006  DT.121328942  DT.121328988  DT.95125695  DT.100702007  DT.121328896 

    24/1926 AceView cDNA sequences (see all 1926):

    AV653802 AA877423 BM971670 AI587442 AW510345 CA840916 BX437224 CD676899 
    AA496852 F24377 AI342354 BP366678 BQ029953 AA383291 CR612183 AY594328 
    AI097363 AA398576 AA135352 BF724841 BQ050710 AI699231 CA975878 BI495860 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TXNIP    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:        -                                                     -                           
    SP2:                                                                                          
    SP3:                                                              -                           
    SP4:                                                              -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for TXNIP

    Expression
    for TXNIP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TXNIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTTGTATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TXNIP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    OvaryAntral FollicleCumulus CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    White adipocyte-like cells (Differentiation of ...)Adipose

    See TXNIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TXNIP

    SOURCE GeneReport for Unigene cluster: Hs.709057
        SABiosciences Expression via Pathway-Focused PCR Arrays including TXNIP (see all 9): 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNIP
    In Situ
    Assay Products:     
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    Orthologs
    for TXNIP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TXNIP gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia TXNIP6
    		 --
    		 70(a)
    		 1 ↔ 1
    		 AAWZ02041877(2101-4231)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.275682 Xenopus laevis transcribed sequence with moderate similarity more 77.22(n)    CF282848.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii txnip2 thioredoxin interacting protein 77.48(n)   368359  BC049493.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Vdup16
    		 Vitamin D[[3]] up-regulated protein 1
    		 20(a)
    		 1 → many
    		 3L(176306-178963)
    worm
    (Caenorhabditis elegans)    		 Secernentea arrd-66
    		 Protein ARRD-6, isoform a
    		 14(a)
    		 possible ortholog
    		 II(11142693-11150323)


    ENSEMBL Gene Tree for TXNIP (if available)
    TreeFam Gene Tree for TXNIP (if available) 

    Paralogs
    for TXNIP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TXNIP gene
    ARRDC32  ARRDC12  ARRDC22  ARRDC42  
    3 SIMAP similar genes for TXNIP using alignment to 4 protein entries:     TXNIP_HUMAN (see all proteins):
    ARRDC4    ARRDC3    ARRDC2

    TXNIP for paralogs           About GeneDecksing



    Genomic Variants
    for TXNIP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/172 NCBI SNPs in TXNIP are shown (see all 172)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs20273891,2
    		C,F,A,--145436482(+) gaggcG/Agagaa 1 -- us2k14Minor allele frequency- A:0.10CSA WA 123
    rs1167363901,2
    		C,F,--145436632(+) CAATCA/GATATT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs121248811,2
    		H--145436727(+) TGTTCC/GTGGGG 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs22365661,2
    		C,F,H,--145436886(+) GAATAG/TGTTTT 1 -- us2k113Minor allele frequency- T:0.09NS EA NA 1994
    rs1824481641,2
    		--145436924(+) GTTTCA/GATATA 1 -- us2k10--------
    rs1503841211,2
    		--145436927(+) TCAATA/GTACTT 1 -- us2k10--------
    rs1879207921,2
    		--145437152(+) TCACAA/GCCAGC 1 -- us2k10--------
    rs22365671,2
    		C,F,H,--145437217(+) GAGGGT/CAGGGT 1 -- us2k17Minor allele frequency- C:0.06EA NS NA 732
    rs1926419951,2
    		--145437220(+) GGTAGA/GGTCTC 1 -- us2k10--------
    rs172217441,2
    		C,F,--145437310(+) AAAAAC/TCNNNN 1 -- us2k1 tfbs31Minor allele frequency- T:0.07NA 120

    HapMap Linkage Disequilibrium report for TXNIP (145438462 - 145442635 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for TXNIP
         5 CNVs: 2324 5199 53561 4252 3310

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TXNIP
    DNA2.0 Custom Variant and Variant Library Synthesis for TXNIP

    Disorders / Diseases
    for TXNIP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TXNIP for disorders           About GeneDecksing

    OMIM gene information: 606599    OMIM disorders: --

    20/33 diseases for TXNIP (see all 33):    About MalaCards
    familial combined hyperlipidemia    lactic acidosis    b-cell lymphomas    hyperlipidemia
    diabetes mellitus    acute lymphoblastic leukemia    lymphoblastic leukemia    ulcerative colitis
    hyperglycemia    multiple myeloma    melanoma metastasis    hepatitis c
    breast cancer    myeloma    melanoma    colon carcinoma
    hepatocellular carcinoma    endometriosis    gastric cancer    pancreatic cancer

    2 diseases from the University of Copenhagen DISEASES database for TXNIP:
    Diabetes mellitus     Hyperglycemia

    10/13 Novoseek disease relationships for TXNIP gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperlipidemia familial combined 61.5 2 15136067 (1), 15368498 (1)
    hyperglycemia 45.7 12 15128745 (3), 17575238 (2), 17555594 (2), 15687841 (1) (see all 5)
    nonmetastatic 31.2 5 17575238 (1)
    tumors 25.6 34 12821938 (3), 20138028 (2), 15930262 (2), 18062927 (2) (see all 18)
    cancer 17.8 15 19773351 (2), 17034356 (1), 17671698 (1), 19351825 (1) (see all 12)
    niddm 14.1 3 17381501 (1), 20075245 (1)
    cardiovascular diseases 2.67 1 17172268 (1)
    shock 0 4 14766217 (3), 17675577 (1)
    breast cancer 0 3 12744759 (1), 15345672 (1), 11126200 (1)
    metastasis 0 8 12543799 (4), 12744759 (1), 18062927 (1), 20068034 (1)

    Human Genome Epidemiology (HuGE) Navigator: TXNIP (5 documents)

    Export disorders for TXNIP gene to outside databases

    Publications
    for TXNIP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TXNIP gene, integrated from 9 sources (see all 167):
    (articles sorted by number of sources associating them with TXNIP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3. (PubMed id 8086474)1, 2, 3, 9 Chen K.-S. and DeLuca H.F. (1994)
    2. The ubiquitin ligase itch regulates apoptosis by targ eting thioredoxin-interacting protein for ubiquitin-dependent degradation. (PubMed id 20068034)1, 2, 9 Zhang P....Yu L. (2010)
    3. VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. (PubMed id 12821938)1, 2, 9 Han S.H.... Choi I. (2003)
    4. hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip. (PubMed id 18541147)1, 2, 9 Shin K.H....Park N.H. (2008)
    5. Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2). (PubMed id 17603038)1, 2, 9 Liyanage N.P.M.... Lou M.F. (2007)
    6. TXNIP potentiates Redd1-induced mTOR suppression thro ugh stabilization of Redd1. (PubMed id 21460850)1, 2 Jin H.O....Park I.C. (2011)
    7. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Thioredoxin-interacting protein: an oxidative stress-related gene is upregulated by glucose in human prostate carcinoma cells. (PubMed id 19052253)1, 9 Pang S.T....Juang H.H. (2009)

    External Searches for TXNIP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TXNIP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10628 HGNC: 16952 AceView: TXNIP Ensembl:ENSG00000117289 euGenes: HUgn10628
    ECgene: TXNIP H-InvDB: TXNIP

    Other Databases showing TXNIP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TXNIP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TXNIP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TXNIP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TXNIP gene:
    Search GeneIP for patents involving TXNIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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