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Aliases for TXNIP Gene

Aliases for TXNIP Gene

  • Thioredoxin Interacting Protein 2 3 5
  • Upregulated By 1,25-Dihydroxyvitamin D-3 2 3
  • Vitamin D3 Up-Regulated Protein 1 3 4
  • Thioredoxin Binding Protein 2 2 3
  • VDUP1 3 4
  • Thioredoxin-Interacting Protein 3
  • Thioredoxin-Binding Protein 2 4
  • EST01027 3
  • HHCPA78 3
  • ARRDC6 3
  • THIF 3

External Ids for TXNIP Gene

Previous GeneCards Identifiers for TXNIP Gene

  • GC01P143959
  • GC01P142025
  • GC01P143165
  • GC01P143187
  • GC01P142927
  • GC01P144149
  • GC01P145438
  • GC01P119402

Summaries for TXNIP Gene

Entrez Gene Summary for TXNIP Gene

  • This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for TXNIP Gene

TXNIP (Thioredoxin Interacting Protein) is a Protein Coding gene. Diseases associated with TXNIP include Hyperglycemia. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Glucose / Energy Metabolism. GO annotations related to this gene include ubiquitin protein ligase binding and enzyme inhibitor activity. An important paralog of this gene is ARRDC4.

UniProtKB/Swiss-Prot for TXNIP Gene

  • May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Gene Wiki entry for TXNIP Gene

Additional gene information for TXNIP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNIP Gene

Genomics for TXNIP Gene

Regulatory Elements for TXNIP Gene

Enhancers for TXNIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H145990 1.8 FANTOM5 ENCODE dbSUPER 12.2 +1.3 1289 10 MLX FEZF1 DMAP1 YY1 SLC30A9 NFYC MEF2D SSRP1 ZNF610 RCOR2 POLR3C LIX1L-AS1 NBPF20 PIAS3 ENSG00000213240 TXNIP HFE2 RBM8A GPR89A PEX11B
GH01H146034 1.5 ENCODE dbSUPER 12.5 -40.9 -40921 5 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZFP41 MEF2D SSRP1 PIAS3 POLR3C NBPF20 GPR89A GNRHR2 NUDT17 ENSG00000213240 ANKRD35 TXNIP PEX11B
GH01H145890 1.4 Ensembl ENCODE 11.2 +104.3 104324 3 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF143 ANKRD35 POLR3C TXNIP ENSG00000244619
GH01H145954 1.3 Ensembl ENCODE 11.3 +39.9 39933 4 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 YY1 GLIS2 ELK1 LIX1L-AS1 POLR3C RBM8A PEX11B GNRHR2 TXNIP ITGA10 HFE2 ENSG00000213240 ANKRD35
GH01H145959 1.1 ENCODE 12.7 +34.2 34199 6 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 POLR3C LIX1L-AS1 RBM8A TXNIP GNRHR2 PEX11B ENSG00000213240 PIAS3 NBPF20 LIX1L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TXNIP on UCSC Golden Path with GeneCards custom track

Promoters for TXNIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000012954 831 4001 MLX FEZF1 DMAP1 YY1 SLC30A9 NFYC MEF2D ZNF610 RCOR2 NBN

Genomic Location for TXNIP Gene

Chromosome:
1
Start:
145,992,435 bp from pter
End:
145,996,631 bp from pter
Size:
4,197 bases
Orientation:
Minus strand

Genomic View for TXNIP Gene

Genes around TXNIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNIP Gene

Proteins for TXNIP Gene

  • Protein details for TXNIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3M7-TXNIP_HUMAN
    Recommended name:
    Thioredoxin-interacting protein
    Protein Accession:
    Q9H3M7
    Secondary Accessions:
    • B4E3D3
    • Q16226
    • Q6PML0
    • Q9BXG9

    Protein attributes for TXNIP Gene

    Size:
    391 amino acids
    Molecular mass:
    43661 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.

    Three dimensional structures from OCA and Proteopedia for TXNIP Gene

    Alternative splice isoforms for TXNIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TXNIP Gene

Post-translational modifications for TXNIP Gene

  • Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
  • Ubiquitination at Lys26, Lys212, posLast=228228, posLast=233233, and Lys287
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNIP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TXNIP (TXNIP)

No data available for DME Specific Peptides for TXNIP Gene

Domains & Families for TXNIP Gene

Gene Families for TXNIP Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for TXNIP Gene

Suggested Antigen Peptide Sequences for TXNIP Gene

Graphical View of Domain Structure for InterPro Entry

Q9H3M7

UniProtKB/Swiss-Prot:

TXNIP_HUMAN :
  • Belongs to the arrestin family.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with TXNIP: view

Function for TXNIP Gene

Molecular function for TXNIP Gene

UniProtKB/Swiss-Prot Function:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
UniProtKB/Swiss-Prot Induction:
By 1,25-dihydroxyvitamin D-3 and TGFB1. Down-regulated in response to oxidative stress.

Phenotypes From GWAS Catalog for TXNIP Gene

Gene Ontology (GO) - Molecular Function for TXNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
GO:0005515 protein binding IPI 10814541
GO:0031625 ubiquitin protein ligase binding IPI 20068034
genes like me logo Genes that share ontologies with TXNIP: view
genes like me logo Genes that share phenotypes with TXNIP: view

Animal Models for TXNIP Gene

MGI Knock Outs for TXNIP:

Animal Model Products

CRISPR Products

miRNA for TXNIP Gene

miRTarBase miRNAs that target TXNIP

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TXNIP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TXNIP Gene

Localization for TXNIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNIP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNIP gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
mitochondrion 3
endoplasmic reticulum 2
extracellular 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TXNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA 14632196
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TXNIP: view

Pathways & Interactions for TXNIP Gene

genes like me logo Genes that share pathways with TXNIP: view

Pathways by source for TXNIP Gene

Gene Ontology (GO) - Biological Process for TXNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006606 protein import into nucleus IEA --
GO:0006979 response to oxidative stress IEA --
genes like me logo Genes that share ontologies with TXNIP: view

No data available for SIGNOR curated interactions for TXNIP Gene

Drugs & Compounds for TXNIP Gene

(4) Drugs for TXNIP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TXNIP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TXNIP: view

Transcripts for TXNIP Gene

Unigene Clusters for TXNIP Gene

Thioredoxin interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TXNIP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TXNIP Gene

No ASD Table

Relevant External Links for TXNIP Gene

GeneLoc Exon Structure for
TXNIP
ECgene alternative splicing isoforms for
TXNIP

Expression for TXNIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNIP Gene

Protein differential expression in normal tissues from HIPED for TXNIP Gene

This gene is overexpressed in Breast (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TXNIP Gene



NURSA nuclear receptor signaling pathways regulating expression of TXNIP Gene:

TXNIP

SOURCE GeneReport for Unigene cluster for TXNIP Gene:

Hs.709057

Evidence on tissue expression from TISSUES for TXNIP Gene

  • Nervous system(5)
  • Blood(4.8)
  • Intestine(4.8)
  • Lung(4.8)
  • Eye(4.7)
  • Kidney(4.6)
  • Spleen(4.6)
  • Pancreas(4.4)
  • Heart(4.3)
  • Muscle(4.2)
  • Stomach(4)
  • Liver(3.7)
  • Skin(3.1)
  • Lymph node(2.9)
  • Gall bladder(2.4)
  • Thyroid gland(2.4)
  • Adrenal gland(2.3)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with TXNIP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNIP Gene

Orthologs for TXNIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TXNIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNIP 33
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia TXNIP 33
  • 91.22 (n)
cow
(Bos Taurus)
Mammalia TXNIP 33
  • 91.13 (n)
rat
(Rattus norvegicus)
Mammalia Txnip 33
  • 89.37 (n)
mouse
(Mus musculus)
Mammalia Txnip 33 16
  • 89.2 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia txnip 33
  • 73.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.27568 33
zebrafish
(Danio rerio)
Actinopterygii txnipa 33
  • 64.29 (n)
txnip 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4823 33
Species where no ortholog for TXNIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNIP Gene

ENSEMBL:
Gene Tree for TXNIP (if available)
TreeFam:
Gene Tree for TXNIP (if available)

Paralogs for TXNIP Gene

Paralogs for TXNIP Gene

(3) SIMAP similar genes for TXNIP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TXNIP: view

Variants for TXNIP Gene

Sequence variations from dbSNP and Humsavar for TXNIP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000189985 -- 145,994,787(+) TGGAT(A/G)GAAAT reference, synonymous-codon
rs1000219417 -- 145,995,017(+) TTTTT(A/G)GCAGA reference, synonymous-codon
rs1000527363 -- 145,993,600(+) CCTGA(C/G)TTTTT utr-variant-3-prime
rs1001438478 -- 145,998,625(+) CACCA(C/T)GCCCA upstream-variant-2KB
rs1001896968 -- 145,998,573(+) AGAGC(A/G)ATTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TXNIP Gene

Variant ID Type Subtype PubMed ID
nsv1005055 CNV loss 25217958
nsv509457 CNV insertion 20534489
nsv831359 CNV loss 17160897
nsv950948 CNV duplication 24416366

Variation tolerance for TXNIP Gene

Residual Variation Intolerance Score: 25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNIP Gene

Disorders for TXNIP Gene

MalaCards: The human disease database

(1) MalaCards diseases for TXNIP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hyperglycemia
- elite association - COSMIC cancer census association via MalaCards
Search TXNIP in MalaCards View complete list of genes associated with diseases

Relevant External Links for TXNIP

Genetic Association Database (GAD)
TXNIP
Human Genome Epidemiology (HuGE) Navigator
TXNIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXNIP
genes like me logo Genes that share disorders with TXNIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXNIP Gene

Publications for TXNIP Gene

  1. Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3. (PMID: 8086474) Chen KS … DeLuca HF (Biochimica et biophysica acta 1994) 2 3 4 22 60
  2. The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. (PMID: 20068034) Zhang P … Yu L (The Journal of biological chemistry 2010) 3 4 22 60
  3. hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip. (PMID: 18541147) Shin KH … Park NH (Biochemical and biophysical research communications 2008) 3 4 22 60
  4. Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2). (PMID: 17603038) Liyanage NP … Lou MF (Experimental eye research 2007) 3 4 22 60
  5. Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus. (PMID: 17381501) van Greevenbroek MM … de Bruin TW (Diabetic medicine : a journal of the British Diabetic Association 2007) 3 22 45 60

Products for TXNIP Gene

Sources for TXNIP Gene

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