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Aliases for TXNDC9 Gene

Aliases for TXNDC9 Gene

  • Thioredoxin Domain Containing 9 2 3
  • ATP-Binding Protein Associated With Cell Differentiation 3 4
  • Protein 1-4 3 4
  • PHLP3 3 6
  • APACD 3 4
  • ATP Binding Protein Associated With Cell Differentiation 3
  • Thioredoxin Domain-Containing Protein 9 3

External Ids for TXNDC9 Gene

Summaries for TXNDC9 Gene

Entrez Gene Summary for TXNDC9 Gene

  • The protein encoded by this gene is a member of the thioredoxin family. The exact function of this protein is not known but it is associated with cell differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TXNDC9 Gene

TXNDC9 (Thioredoxin Domain Containing 9) is a Protein Coding gene. Diseases associated with TXNDC9 include pellagra and akinetic mutism.

UniProtKB/Swiss-Prot for TXNDC9 Gene

  • Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.

Gene Wiki entry for TXNDC9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC9 Gene

Genomics for TXNDC9 Gene

Genomic Location for TXNDC9 Gene

Start:
99,318,982 bp from pter
End:
99,340,702 bp from pter
Size:
21,721 bases
Orientation:
Minus strand

Genomic View for TXNDC9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXNDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC9 Gene

Regulatory Elements for TXNDC9 Gene

Proteins for TXNDC9 Gene

  • Protein details for TXNDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14530-TXND9_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 9
    Protein Accession:
    O14530
    Secondary Accessions:
    • B2R9G8
    • D3DVI4
    • Q53HG4
    • Q53RV8
    • Q6NSF5
    • Q8TB70
    • Q9BRU6

    Protein attributes for TXNDC9 Gene

    Size:
    226 amino acids
    Molecular mass:
    26534 Da
    Quaternary structure:
    • Forms ternary complexes with the chaperonin TCP1 complex, spanning the cylindrical chaperonin cavity and contacting at least 2 subunits

    Alternative splice isoforms for TXNDC9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TXNDC9 Gene

Proteomics data for TXNDC9 Gene at MOPED

Post-translational modifications for TXNDC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TXNDC9 Gene

No data available for DME Specific Peptides for TXNDC9 Gene

Domains for TXNDC9 Gene

Protein Domains for TXNDC9 Gene

UniProtKB/Swiss-Prot:

TXND9_HUMAN
Domain:
  • Contains 1 thioredoxin domain.:
    • O14530
genes like me logo Genes that share domains with TXNDC9: view

No data available for Gene Families for TXNDC9 Gene

Function for TXNDC9 Gene

Molecular function for TXNDC9 Gene

UniProtKB/Swiss-Prot Function: Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.

Gene Ontology (GO) - Molecular Function for TXNDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with TXNDC9: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TXNDC9 Gene

Localization for TXNDC9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXNDC9 Gene COMPARTMENTS Subcellular localization image for TXNDC9 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TXNDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with TXNDC9: view

Pathways for TXNDC9 Gene

SuperPathways for TXNDC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TXNDC9: view

No data available for Pathways by source for TXNDC9 Gene

Transcripts for TXNDC9 Gene

Unigene Clusters for TXNDC9 Gene

Thioredoxin domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC9 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - - -
SP7:

Relevant External Links for TXNDC9 Gene

GeneLoc Exon Structure for
TXNDC9
ECgene alternative splicing isoforms for
TXNDC9

Expression for TXNDC9 Gene

mRNA expression in normal human tissues for TXNDC9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXNDC9 Gene

SOURCE GeneReport for Unigene cluster for TXNDC9 Gene Hs.536122

genes like me logo Genes that share expressions with TXNDC9: view

Orthologs for TXNDC9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXNDC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNDC9 36
  • 99.85 (n)
  • 99.56 (a)
TXNDC9 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TXNDC9 36
  • 92.85 (n)
  • 93.61 (a)
TXNDC9 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TXNDC9 36
  • 93.46 (n)
  • 95.43 (a)
TXNDC9 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Txndc9 36
  • 85.54 (n)
  • 89.5 (a)
Txndc9 16
Txndc9 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TXNDC9 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TXNDC9 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Txndc9 36
  • 85.24 (n)
  • 88.58 (a)
chicken
(Gallus gallus)
Aves TXNDC9 36
  • 80.67 (n)
  • 82.19 (a)
TXNDC9 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TXNDC9 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia apacd-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2720 36
txndc9 36
  • 79 (n)
  • 81.74 (a)
zebrafish
(Danio rerio)
Actinopterygii txndc9 36
  • 70.68 (n)
  • 75.93 (a)
txndc9 37
  • 74 (a)
OneToOne
wufb15e07 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003485 36
  • 54.67 (n)
  • 53.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4511 36
  • 56.98 (n)
  • 53.69 (a)
CG4511 37
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-170 36
  • 52.33 (n)
  • 44.69 (a)
tag-170 37
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLP1 37
  • 29 (a)
OneToOne
PLP1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons TXND9 36
  • 57.95 (n)
  • 52.84 (a)
rice
(Oryza sativa)
Liliopsida Os08g0250700 36
  • 52.14 (n)
  • 49.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4777 37
  • 58 (a)
OneToOne
Species with no ortholog for TXNDC9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNDC9 Gene

ENSEMBL:
Gene Tree for TXNDC9 (if available)
TreeFam:
Gene Tree for TXNDC9 (if available)

Paralogs for TXNDC9 Gene

Pseudogenes.org Pseudogenes for TXNDC9 Gene

genes like me logo Genes that share paralogs with TXNDC9: view

No data available for Paralogs for TXNDC9 Gene

Variants for TXNDC9 Gene

Sequence variations from dbSNP and Humsavar for TXNDC9 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6706425 -- 99,325,212(+) aaaca(C/T)tgcat intron-variant
rs6706654 -- 99,325,366(+) TGAGT(C/T)AATTT intron-variant
rs6708861 -- 99,330,771(+) ACCCT(C/T)GTGGA intron-variant
rs6709085 -- 99,330,926(+) AAGAC(C/T)CTCTG intron-variant
rs6709240 -- 99,331,075(+) TTTAA(C/T)GTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC9 Gene

Variant ID Type Subtype PubMed ID
nsv874699 CNV Gain 21882294
nsv524466 CNV Loss 19592680

Relevant External Links for TXNDC9 Gene

HapMap Linkage Disequilibrium report
TXNDC9

Disorders for TXNDC9 Gene

(3) University of Copenhagen DISEASES for TXNDC9 Gene

genes like me logo Genes that share disorders with TXNDC9: view

No data available for UniProtKB/Swiss-Prot for TXNDC9 Gene

Publications for TXNDC9 Gene

  1. PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates. (PMID: 16415341) Stirling P.C. … Leroux M.R. (J. Biol. Chem. 2006) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for TXNDC9 Gene

Sources for TXNDC9 Gene

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