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Aliases for TXNDC9 Gene

Aliases for TXNDC9 Gene

  • Thioredoxin Domain Containing 9 2 3 5
  • ATP-Binding Protein Associated With Cell Differentiation 3 4
  • Protein 1-4 3 4
  • APACD 3 4
  • ATP Binding Protein Associated With Cell Differentiation 3
  • PHLP3 3

External Ids for TXNDC9 Gene

Previous GeneCards Identifiers for TXNDC9 Gene

  • GC02M099557
  • GC02M099394
  • GC02M099935
  • GC02M093700
  • GC02M099921

Summaries for TXNDC9 Gene

Entrez Gene Summary for TXNDC9 Gene

  • The protein encoded by this gene is a member of the thioredoxin family. The exact function of this protein is not known but it is associated with cell differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TXNDC9 Gene

TXNDC9 (Thioredoxin Domain Containing 9) is a Protein Coding gene. Diseases associated with TXNDC9 include Akinetic Mutism.

UniProtKB/Swiss-Prot for TXNDC9 Gene

  • Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.

Gene Wiki entry for TXNDC9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC9 Gene

Genomics for TXNDC9 Gene

Regulatory Elements for TXNDC9 Gene

Enhancers for TXNDC9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TXNDC9 on UCSC Golden Path with GeneCards custom track

Genomic Location for TXNDC9 Gene

99,318,982 bp from pter
99,340,702 bp from pter
21,721 bases
Minus strand

Genomic View for TXNDC9 Gene

Genes around TXNDC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC9 Gene

Proteins for TXNDC9 Gene

  • Protein details for TXNDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 9
    Protein Accession:
    Secondary Accessions:
    • B2R9G8
    • D3DVI4
    • Q53HG4
    • Q53RV8
    • Q6NSF5
    • Q8TB70
    • Q9BRU6

    Protein attributes for TXNDC9 Gene

    226 amino acids
    Molecular mass:
    26534 Da
    Quaternary structure:
    • Forms ternary complexes with the chaperonin TCP1 complex, spanning the cylindrical chaperonin cavity and contacting at least 2 subunits.

    Alternative splice isoforms for TXNDC9 Gene


neXtProt entry for TXNDC9 Gene

Proteomics data for TXNDC9 Gene at MOPED

Post-translational modifications for TXNDC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TXNDC9 Gene

No data available for DME Specific Peptides for TXNDC9 Gene

Domains & Families for TXNDC9 Gene

Protein Domains for TXNDC9 Gene

Suggested Antigen Peptide Sequences for TXNDC9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Contains 1 thioredoxin domain.
genes like me logo Genes that share domains with TXNDC9: view

No data available for Gene Families for TXNDC9 Gene

Function for TXNDC9 Gene

Molecular function for TXNDC9 Gene

UniProtKB/Swiss-Prot Function:
Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.
genes like me logo Genes that share phenotypes with TXNDC9: view

Animal Model Products

miRNA for TXNDC9 Gene

miRTarBase miRNAs that target TXNDC9

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNDC9 Gene

Localization for TXNDC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC9 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Co-localizes with beta-tubulin in the centrosome. {ECO:0000250 UniProtKB:Q9CQ79}.

Subcellular locations from

Jensen Localization Image for TXNDC9 Gene COMPARTMENTS Subcellular localization image for TXNDC9 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TXNDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TXNDC9: view

Pathways & Interactions for TXNDC9 Gene

SuperPathways for TXNDC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC9 Gene


No data available for Pathways by source and SIGNOR curated interactions for TXNDC9 Gene

Drugs & Compounds for TXNDC9 Gene

No Compound Related Data Available

Transcripts for TXNDC9 Gene

Unigene Clusters for TXNDC9 Gene

Thioredoxin domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC9 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - - -

Relevant External Links for TXNDC9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC9 Gene

mRNA expression in normal human tissues for TXNDC9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TXNDC9 Gene

This gene is overexpressed in Breast (32.2) and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXNDC9 Gene

SOURCE GeneReport for Unigene cluster for TXNDC9 Gene Hs.536122

genes like me logo Genes that share expression patterns with TXNDC9: view

Protein tissue co-expression partners for TXNDC9 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TXNDC9 Gene

Orthologs for TXNDC9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXNDC9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TXNDC9 35
  • 92.85 (n)
  • 93.61 (a)
  • 94 (a)
(Canis familiaris)
Mammalia TXNDC9 35
  • 93.46 (n)
  • 95.43 (a)
  • 86 (a)
(Mus musculus)
Mammalia Txndc9 35
  • 85.54 (n)
  • 89.5 (a)
Txndc9 16
Txndc9 36
  • 90 (a)
(Pan troglodytes)
Mammalia TXNDC9 35
  • 99.85 (n)
  • 99.56 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Txndc9 35
  • 85.24 (n)
  • 88.58 (a)
(Monodelphis domestica)
Mammalia TXNDC9 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia TXNDC9 36
  • 92 (a)
(Gallus gallus)
Aves TXNDC9 35
  • 80.67 (n)
  • 82.19 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia TXNDC9 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2720 35
txndc9 35
  • 79 (n)
  • 81.74 (a)
African clawed frog
(Xenopus laevis)
Amphibia apacd-prov 35
(Danio rerio)
Actinopterygii txndc9 35
  • 70.68 (n)
  • 75.93 (a)
wufb15e07 35
txndc9 36
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003485 35
  • 54.67 (n)
  • 53.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4511 35
  • 56.98 (n)
  • 53.69 (a)
CG4511 36
  • 53 (a)
(Caenorhabditis elegans)
Secernentea tag-170 35
  • 52.33 (n)
  • 44.69 (a)
tag-170 36
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLP1 36
  • 29 (a)
PLP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TXND9 35
  • 57.95 (n)
  • 52.84 (a)
(Oryza sativa)
Liliopsida Os08g0250700 35
  • 52.14 (n)
  • 49.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4777 36
  • 58 (a)
Species with no ortholog for TXNDC9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNDC9 Gene

Gene Tree for TXNDC9 (if available)
Gene Tree for TXNDC9 (if available)

Paralogs for TXNDC9 Gene Pseudogenes for TXNDC9 Gene

genes like me logo Genes that share paralogs with TXNDC9: view

No data available for Paralogs for TXNDC9 Gene

Variants for TXNDC9 Gene

Sequence variations from dbSNP and Humsavar for TXNDC9 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_058327 -
rs11542369 - 99,333,170(-) AGTCC(A/T)GGAGC reference, missense
rs11542371 - 99,333,098(-) GGATC(A/G)GATGG reference, missense
rs7609108 -- 99,320,222(+) aggct(G/T)gtctt intron-variant
rs14573 -- 99,319,296(-) CGCAA(A/T)ACTGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TXNDC9 Gene

Variant ID Type Subtype PubMed ID
nsv874699 CNV Gain 21882294
nsv524466 CNV Loss 19592680

Variation tolerance for TXNDC9 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TXNDC9 Gene

Disorders for TXNDC9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TXNDC9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
akinetic mutism
  • coma vigilans
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TXNDC9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TXNDC9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXNDC9 Gene

Publications for TXNDC9 Gene

  1. PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates. (PMID: 16415341) Stirling P.C. … Leroux M.R. (J. Biol. Chem. 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for TXNDC9 Gene

Sources for TXNDC9 Gene