TXNDC8 Gene
protein-coding GIFtS: 44
GCID: GC09M113065
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thioredoxin domain containing 8 (spermatozoa)
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Aliases
for TXNDC8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thioredoxin Domain Containing 8 (Spermatozoa)1 2 | | Thioredoxin 62 | | TRX61 2 3 | | Thioredoxin Domain-Containing Protein 82 | | SPTRX-31 2 | | Thioredoxin-63 | | BA427L11.21 | | SPTRX33 | | Spermatid-Specific Thioredoxin-32 3 | | Sptrx-33 | | Sperm-Specific Thioredoxin 32 | | Thioredoxin-63 | | Spermatocyte/Spermatid-Specific Thioredoxin-32 | | |
Export aliases for TXNDC8 gene to outside databasesPrevious GC identifers: GC09U900588 GC09M110145 GC09M112105 GC09M082667 |
Summaries
for TXNDC8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TXND8_HUMAN, Q6A555Function: May be required for post-translational modifications of proteins required for acrosomal biogenesis. May actby reducing disulfide bonds within the sperm
|
Genomic Views
for TXNDC8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TXNDC8 gene promoter:
STAT5B STAT4 STAT6 STAT5A CUTL1 HNF-1A Nkx6-1 HNF-1 STAT3 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TXNDC8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q31.3 Ensembl cytogenetic band: 9q31.3 HGNC cytogenetic band: 9q31.3TXNDC8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M113065: view genomic region
(about GC identifiers)
Start:
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113,065,801 bp from pter |
End:
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113,100,127 bp from pter |
Size:
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34,327 bases |
Orientation:
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minus strand |
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Proteins
for TXNDC8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TXND8_HUMAN, Q6A555 (See
protein sequence)Recommended Name: Thioredoxin domain-containing protein 8 Size: 127 amino acids; 14575 Da
Subcellular location: Cytoplasm. Golgi apparatus
Miscellaneous: Increased levels, possibly caused by overexpression, are observed in morphologically abnormalspermatozoa from infertile men, suggesting that it may be used as a marker of aberrant spermatogenesis
Sequence caution: Sequence=CAI14069.1; Type=Erroneous gene model prediction;
Secondary accessions: A1L4I2 A6NDK7 Q5T934Alternative splicing: 2 isoforms: Q6A555-1 Q6A555-2 Explore the universe of human proteins at neXtProt for TXNDC8: NX_Q6A555
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6A555
TXNDC8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001003936.1
ENSEMBL proteins: ENSP00000363634 ENSP00000408768 ENSP00000363631 ENSP00000363635
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TXNDC8 for ontologies About GeneDecksing
TXNDC8 Antibody Products:
Assay Products for TXNDC8: |
Protein
Domains /
Families
for TXNDC8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TXNDC8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6A555ProtoNet protein and cluster: Q6A555 1 Blocks protein family: IPB006662 Thioredoxin type domain
UniProtKB/Swiss-Prot: TXND8_HUMAN, Q6A555Similarity: Belongs to the thioredoxin familySimilarity: Contains 1 thioredoxin domain |
Function
for TXNDC8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TXND8_HUMAN, Q6A555Function: May be required for post-translational modifications of proteins required for acrosomal biogenesis. May actby reducing disulfide bonds within the sperm
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TXNDC8 (NM_001003936) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TXNDC8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC8 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009055 | electron carrier activity |
IEA | -- | | GO:0015035 | protein disulfide oxidoreductase activity |
IEA | -- |
TXNDC8 for ontologies About GeneDecksing
|
Pathways & Interactions
for TXNDC8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TXNDC8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for TXNDC8 (ENSP000003636344) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
TXNDC8 for ontologies About GeneDecksing
|
Drugs & Compounds
for TXNDC8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TXNDC8
Search CenterWatch for drugs/clinical trials and news about TXNDC8 / TXND8
|
Transcripts
for TXNDC8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TXNDC8 gene: NM_001003936.2 Unigene Cluster for TXNDC8: Thioredoxin domain containing 8 (spermatozoa) Hs.147064 [show with all ESTs]Unigene Representative Sequence: BM5598025 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374510(uc004bes.3 uc011lwl.2) ENST00000423740 ENST00000461950
ENST00000374507 ENST00000374511
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TXNDC8 (NM_001003936) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TXNDC8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC8 |
Additional cDNA sequence: AF305830.1 BC130549.1 BC130551.1 BC144461.1 3 DOTS entries: DT.75118799 DT.121164752 DT.97784391 6 AceView cDNA sequences: BC035743 BM559802 BX111879 AF305830 AI188241 NM_001003936
GeneLoc Exon Structure
|
Expression
for TXNDC8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TXNDC8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTATGTCTGT
About this image
See TXNDC8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TXNDC8
SOURCE GeneReport for Unigene cluster: Hs.147064
UniProtKB/Swiss-Prot: TXND8_HUMAN, Q6A555Tissue specificity: Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus ofpachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosomeof round spermatids (at protein level)
SABiosciences Custom PCR Arrays for TXNDC8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXNDC8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXNDC8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC8 |
Orthologs
for TXNDC8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TXNDC8 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for TXNDC8 (if available)
TreeFam Gene Tree for TXNDC8 (if available) |
Paralogs
for TXNDC8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TXNDC8 gene
- TXN2 TXNDC22 TXNL12
3 SIMAP similar genes for TXNDC8 using alignment to 3 protein entries: TXND8_HUMAN (see all proteins):TXNL1 TXN TXNDC2
TXNDC8 for paralogs About GeneDecksing
|
Genomic Variants
for TXNDC8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TXNDC8 (113065801 - 113100127 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TXNDC8
1 CNV: 8630 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TXNDC8 |
|
Disorders
/ Diseases
for TXNDC8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TXNDC8 for disorders About GeneDecksing
5  diseases for TXNDC8: About MalaCardsinfertility pneumonia tuberculosis malaria
mycobacterium tuberculosis
Export disorders for TXNDC8 gene to outside databases
|
Publications
for TXNDC8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TXNDC8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TXNDC8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis. (PubMed id 15181017)1, 2, 9 Jimenez A.... Miranda-Vizuete A. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- High throughput, parallel imaging and biomarker quant ification of human spermatozoa by ImageStream flow cytometry. (PubMed id 19938959)9 Buckman C....Sutovsky P. (2009)
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External Searches for TXNDC8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TXNDC8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TXNDC8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TXNDC8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TXNDC8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TXNDC8 gene:
Search GeneIP for patents involving TXNDC8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TXNDC8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TXNDC8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TXNDC8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXNDC8 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TXNDC8 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TXNDC8 | | OriGene Custom Protein Services for TXNDC8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TXNDC8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TXNDC8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNDC8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC8 |
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| | | | Search Tocris compounds for TXNDC8 |
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 | | | TXNDC8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for TXNDC8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC8 |
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