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Aliases for TXNDC8 Gene

Aliases for TXNDC8 Gene

  • Thioredoxin Domain Containing 8 (Spermatozoa) 2 3
  • Spermatid-Specific Thioredoxin-3 3 4
  • Sperm-Specific Thioredoxin 3 2 3
  • SPTRX-3 3 4
  • TRX6 3 4
  • Spermatocyte/Spermatid-Specific Thioredoxin-3 3
  • Thioredoxin Domain-Containing Protein 8 3
  • Thioredoxin 6 3
  • Thioredoxin-6 4
  • BA427L11.2 3
  • SPTRX3 4

External Ids for TXNDC8 Gene

Previous GeneCards Identifiers for TXNDC8 Gene

  • GC09U900588
  • GC09M110145
  • GC09M112105
  • GC09M113065
  • GC09M082667

Summaries for TXNDC8 Gene

GeneCards Summary for TXNDC8 Gene

TXNDC8 (Thioredoxin Domain Containing 8 (Spermatozoa)) is a Protein Coding gene. GO annotations related to this gene include electron carrier activity and protein disulfide oxidoreductase activity. An important paralog of this gene is TXN.

UniProtKB/Swiss-Prot for TXNDC8 Gene

  • May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC8 Gene

Genomics for TXNDC8 Gene

Regulatory Elements for TXNDC8 Gene

Genomic Location for TXNDC8 Gene

110,303,482 bp from pter
110,337,884 bp from pter
34,403 bases
Minus strand

Genomic View for TXNDC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXNDC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC8 Gene

Proteins for TXNDC8 Gene

  • Protein details for TXNDC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • A1L4I2
    • A6NDK7
    • Q5T934

    Protein attributes for TXNDC8 Gene

    127 amino acids
    Molecular mass:
    14575 Da
    Quaternary structure:
    No Data Available
    • Increased levels, possibly caused by overexpression, are observed in morphologically abnormal spermatozoa from infertile men, suggesting that it may be used as a marker of aberrant spermatogenesis
    • Sequence=CAI14069.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TXNDC8 Gene


neXtProt entry for TXNDC8 Gene

Proteomics data for TXNDC8 Gene at MOPED

Post-translational modifications for TXNDC8 Gene

No Post-translational modifications

Other Protein References for TXNDC8 Gene

No data available for DME Specific Peptides for TXNDC8 Gene

Domains for TXNDC8 Gene

Protein Domains for TXNDC8 Gene

Suggested Antigen Peptide Sequences for TXNDC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6A555
  • Contains 1 thioredoxin domain.
  • Belongs to the thioredoxin family.
genes like me logo Genes that share domains with TXNDC8: view

No data available for Gene Families for TXNDC8 Gene

Function for TXNDC8 Gene

Molecular function for TXNDC8 Gene

UniProtKB/Swiss-Prot Function: May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm

Gene Ontology (GO) - Molecular Function for TXNDC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015035 NOT protein disulfide oxidoreductase activity IDA 15181017
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA --
genes like me logo Genes that share ontologies with TXNDC8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TXNDC8 Gene

Localization for TXNDC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC8 Gene

Cytoplasm. Golgi apparatus.

Subcellular locations from

Jensen Localization Image for TXNDC8 Gene COMPARTMENTS Subcellular localization image for TXNDC8 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TXNDC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005737 cytoplasm IDA 15181017
GO:0005739 mitochondrion IBA --
GO:0005794 Golgi apparatus IDA 15181017
GO:0036126 sperm flagellum IEA --
genes like me logo Genes that share ontologies with TXNDC8: view

Pathways for TXNDC8 Gene

SuperPathways for TXNDC8 Gene

No Data Available

Interacting Proteins for TXNDC8 Gene

Gene Ontology (GO) - Biological Process for TXNDC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000103 sulfate assimilation IBA --
GO:0001675 acrosome assembly IEA --
GO:0006457 protein folding IBA --
GO:0006662 glycerol ether metabolic process IEA --
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with TXNDC8: view

No data available for Pathways by source for TXNDC8 Gene

Transcripts for TXNDC8 Gene

mRNA/cDNA for TXNDC8 Gene

(9) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TXNDC8 Gene

Thioredoxin domain containing 8 (spermatozoa):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXNDC8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TXNDC8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC8 Gene

No ASD Table

Relevant External Links for TXNDC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC8 Gene

mRNA expression in normal human tissues for TXNDC8 Gene

mRNA differential expression in normal tissues according to GTEx for TXNDC8 Gene

This gene is overexpressed in Testis (52.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TXNDC8 Gene

SOURCE GeneReport for Unigene cluster for TXNDC8 Gene Hs.147064

mRNA Expression by UniProt/SwissProt for TXNDC8 Gene

Tissue specificity: Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids (at protein level).
genes like me logo Genes that share expressions with TXNDC8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TXNDC8 Gene

Orthologs for TXNDC8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TXNDC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TXNDC8 36
  • 84 (a)
(Bos Taurus)
Mammalia TXNDC8 36
  • 56 (a)
(Canis familiaris)
Mammalia TXNDC8 36
  • 56 (a)
(Mus musculus)
Mammalia Txndc8 35
  • 73.52 (n)
  • 60.75 (a)
Txndc8 16
Txndc8 36
  • 44 (a)
(Monodelphis domestica)
Mammalia TXNDC8 36
  • 33 (a)
(Rattus norvegicus)
Mammalia Txndc8 35
  • 73.2 (n)
  • 61.76 (a)
(Anolis carolinensis)
Reptilia TXNDC8 36
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta TrxT 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea trx-4 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRX1 36
  • 27 (a)
TRX2 36
  • 27 (a)
TRX3 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11205 36
  • 24 (a)
Species with no ortholog for TXNDC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TXNDC8 Gene

Gene Tree for TXNDC8 (if available)
Gene Tree for TXNDC8 (if available)

Paralogs for TXNDC8 Gene

Paralogs for TXNDC8 Gene

Selected SIMAP similar genes for TXNDC8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TXNDC8: view

Variants for TXNDC8 Gene

Sequence variations from dbSNP and Humsavar for TXNDC8 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs980102 -- 110,335,294(-) gcacc(A/G)ctaca intron-variant
rs1318782 -- 110,316,938(+) TGGCT(G/T)TGTTC intron-variant
rs1327541 -- 110,319,825(+) ACCTC(C/T)TTGAT intron-variant
rs1327542 -- 110,324,928(+) ccaac(A/C/T)tggtg intron-variant
rs1984697 -- 110,309,332(+) TAAtt(A/T)tattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC8 Gene

Variant ID Type Subtype PubMed ID
esv2752274 CNV Gain 17911159
nsv893714 CNV Gain 21882294

Relevant External Links for TXNDC8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC8 Gene

Disorders for TXNDC8 Gene

No disorders were found for TXNDC8 Gene.

No data available for UniProtKB/Swiss-Prot for TXNDC8 Gene

Publications for TXNDC8 Gene

  1. Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis. (PMID: 15181017) Jimenez A. … Miranda-Vizuete A. (J. Biol. Chem. 2004) 3 4 23
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  4. Semen levels of spermatid-specific thioredoxin-3 correlate with pregnancy rates in ART couples. (PMID: 23734172) Buckman C. … Sutovsky P. (PLoS ONE 2013) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TXNDC8 Gene

Sources for TXNDC8 Gene

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