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Aliases for TXNDC8 Gene

Aliases for TXNDC8 Gene

  • Thioredoxin Domain Containing 8 2 3
  • Thioredoxin Domain Containing 8 (Spermatozoa) 2 3 5
  • Spermatid-Specific Thioredoxin-3 3 4
  • Sperm-Specific Thioredoxin 3 2 3
  • SPTRX-3 3 4
  • TRX6 3 4
  • Spermatocyte/Spermatid-Specific Thioredoxin-3 3
  • Thioredoxin 6 3
  • Thioredoxin-6 4
  • BA427L11.2 3
  • SPTRX3 4

External Ids for TXNDC8 Gene

Previous GeneCards Identifiers for TXNDC8 Gene

  • GC09U900588
  • GC09M110145
  • GC09M112105
  • GC09M113065
  • GC09M082667

Summaries for TXNDC8 Gene

GeneCards Summary for TXNDC8 Gene

TXNDC8 (Thioredoxin Domain Containing 8) is a Protein Coding gene. GO annotations related to this gene include protein disulfide oxidoreductase activity and oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor. An important paralog of this gene is TXN.

UniProtKB/Swiss-Prot for TXNDC8 Gene

  • May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC8 Gene

Genomics for TXNDC8 Gene

Regulatory Elements for TXNDC8 Gene

Enhancers for TXNDC8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TXNDC8 on UCSC Golden Path with GeneCards custom track

Genomic Location for TXNDC8 Gene

110,276,799 bp from pter
110,337,887 bp from pter
61,089 bases
Minus strand

Genomic View for TXNDC8 Gene

Genes around TXNDC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC8 Gene

Proteins for TXNDC8 Gene

  • Protein details for TXNDC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • A1L4I2
    • A6NDK7
    • Q5T934

    Protein attributes for TXNDC8 Gene

    127 amino acids
    Molecular mass:
    14575 Da
    Quaternary structure:
    No Data Available
    • Increased levels, possibly caused by overexpression, are observed in morphologically abnormal spermatozoa from infertile men, suggesting that it may be used as a marker of aberrant spermatogenesis.
    • Sequence=CAI14069.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TXNDC8 Gene


neXtProt entry for TXNDC8 Gene

Proteomics data for TXNDC8 Gene at MOPED

Post-translational modifications for TXNDC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TXNDC8 Gene

No data available for DME Specific Peptides for TXNDC8 Gene

Domains & Families for TXNDC8 Gene

Protein Domains for TXNDC8 Gene

Suggested Antigen Peptide Sequences for TXNDC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Belongs to the thioredoxin family.
  • Contains 1 thioredoxin domain.
  • Belongs to the thioredoxin family.
genes like me logo Genes that share domains with TXNDC8: view

No data available for Gene Families for TXNDC8 Gene

Function for TXNDC8 Gene

Molecular function for TXNDC8 Gene

UniProtKB/Swiss-Prot Function:
May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm.
genes like me logo Genes that share phenotypes with TXNDC8: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TXNDC8 Gene

Localization for TXNDC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC8 Gene

Cytoplasm. Golgi apparatus.

Subcellular locations from

Jensen Localization Image for TXNDC8 Gene COMPARTMENTS Subcellular localization image for TXNDC8 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
mitochondrion 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TXNDC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005737 cytoplasm IDA 15181017
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TXNDC8: view

Pathways & Interactions for TXNDC8 Gene

SuperPathways for TXNDC8 Gene

No Data Available

Interacting Proteins for TXNDC8 Gene

Gene Ontology (GO) - Biological Process for TXNDC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000103 sulfate assimilation IBA --
GO:0006457 protein folding IBA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEP 15181017
GO:0034599 cellular response to oxidative stress IBA --
genes like me logo Genes that share ontologies with TXNDC8: view

No data available for Pathways by source and SIGNOR curated interactions for TXNDC8 Gene

Drugs & Compounds for TXNDC8 Gene

No Compound Related Data Available

Transcripts for TXNDC8 Gene

mRNA/cDNA for TXNDC8 Gene

(9) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TXNDC8 Gene

Thioredoxin domain containing 8 (spermatozoa):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC8 Gene

No ASD Table

Relevant External Links for TXNDC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC8 Gene

mRNA expression in normal human tissues for TXNDC8 Gene

mRNA differential expression in normal tissues according to GTEx for TXNDC8 Gene

This gene is overexpressed in Testis (x52.8).

Protein differential expression in normal tissues from HIPED for TXNDC8 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TXNDC8 Gene

SOURCE GeneReport for Unigene cluster for TXNDC8 Gene Hs.147064

mRNA Expression by UniProt/SwissProt for TXNDC8 Gene

Tissue specificity: Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids (at protein level).
genes like me logo Genes that share expression patterns with TXNDC8: view

Protein tissue co-expression partners for TXNDC8 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TXNDC8 Gene

Orthologs for TXNDC8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TXNDC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Txndc8 35
  • 73.52 (n)
  • 60.75 (a)
Txndc8 16
Txndc8 36
  • 44 (a)
(Rattus norvegicus)
Mammalia Txndc8 35
  • 73.2 (n)
  • 61.76 (a)
(Bos Taurus)
Mammalia TXNDC8 36
  • 56 (a)
(Canis familiaris)
Mammalia TXNDC8 36
  • 56 (a)
(Monodelphis domestica)
Mammalia TXNDC8 36
  • 33 (a)
(Pan troglodytes)
Mammalia TXNDC8 36
  • 84 (a)
(Anolis carolinensis)
Reptilia TXNDC8 36
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta TrxT 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea trx-4 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRX1 36
  • 27 (a)
TRX2 36
  • 27 (a)
TRX3 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11205 36
  • 24 (a)
Species with no ortholog for TXNDC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TXNDC8 Gene

Gene Tree for TXNDC8 (if available)
Gene Tree for TXNDC8 (if available)

Paralogs for TXNDC8 Gene

Paralogs for TXNDC8 Gene

(2) SIMAP similar genes for TXNDC8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TXNDC8: view

Variants for TXNDC8 Gene

Sequence variations from dbSNP and Humsavar for TXNDC8 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7041938 - 110,329,243(+) ATTGT(G/T)CACAT intron-variant, nc-transcript-variant, reference, missense
rs980102 -- 110,335,294(-) gcacc(A/G)ctaca intron-variant
rs1318782 -- 110,316,938(+) TGGCT(G/T)TGTTC intron-variant
rs1327541 -- 110,319,825(+) ACCTC(C/T)TTGAT intron-variant
rs1327542 -- 110,324,928(+) ccaac(A/C/T)tggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC8 Gene

Variant ID Type Subtype PubMed ID
esv2752274 CNV Gain 17911159
nsv893714 CNV Gain 21882294

Variation tolerance for TXNDC8 Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.73; 78.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TXNDC8 Gene

Disorders for TXNDC8 Gene

Relevant External Links for TXNDC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TXNDC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC8 Gene

Publications for TXNDC8 Gene

  1. Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis. (PMID: 15181017) Jimenez A. … Miranda-Vizuete A. (J. Biol. Chem. 2004) 3 4 23 67
  2. Semen levels of spermatid-specific thioredoxin-3 correlate with pregnancy rates in ART couples. (PMID: 23734172) Buckman C. … Sutovsky P. (PLoS ONE 2013) 3
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  4. High throughput, parallel imaging and biomarker quantification of human spermatozoa by ImageStream flow cytometry. (PMID: 19938959) Buckman C. … Sutovsky P. (Syst Biol Reprod Med 2009) 23
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3

Products for TXNDC8 Gene

Sources for TXNDC8 Gene