Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TXNDC5 Gene

protein-coding   GIFtS: 56
GCID: GC06M007826

Thioredoxin Domain Containing 5 (Endoplasmic Reticulum)

(Previous name: thioredoxin domain containing 5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thioredoxin Domain Containing 5 (Endoplasmic Reticulum)1 2     PDIA152
Endoplasmic Reticulum Resident Protein 462 3     STRF82
Thioredoxin-Like Protein P462 3     UNQ3642
ER Protein 462 3     Endoplasmic Reticulum Protein ERp462
Member 151     Endothelial Protein Disulphide Isomerase2
Protein Disulfide Isomerase Family A1     Protein Disulfide Isomerase Family A, Member 152
Thioredoxin Domain Containing 51     Thioredoxin Domain-Containing Protein 52
ENDOPDI2     Thioredoxin Related Protein2
ERP462     ERp463
HCC-22     TLP463

External Ids:    HGNC: 210731   Entrez Gene: 815672   Ensembl: ENSG000002392647   UniProtKB: Q8NBS93   

Export aliases for TXNDC5 gene to outside databases

Previous GC identifer: GC06M007871


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TXNDC5 Gene:
This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to
protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through
transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. (provided by
RefSeq, Dec 2010)

GeneCards Summary for TXNDC5 Gene: 
TXNDC5 (thioredoxin domain containing 5 (endoplasmic reticulum)) is a protein-coding gene. Diseases associated with TXNDC5 include hypoxia, and vitiligo, and among its related super-pathways are Clathrin derived vesicle budding and Translocation of GLUT4 to the Plasma Membrane. GO annotations related to this gene include isomerase activity and electron carrier activity. An important paralog of this gene is DNAJC10.

UniProtKB/Swiss-Prot: TXND5_HUMAN, Q8NBS9
Function: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements
protein disulfide-isomerase deficiency in yeast (By similarity)

Gene Wiki entry for TXNDC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TXNDC5 gene promoter:
         Nkx3-1   Nkx3-1 v2   Nkx3-1 v3   Nkx3-1 v1   E4BP4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TXNDC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for TXNDC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.3   Ensembl cytogenetic band:  6p24.3   HGNC cytogenetic band: 6p24.3

TXNDC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNDC5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M007826:  view genomic region     (about GC identifiers)

Start:
7,881,483 bp from pter      End:
7,911,047 bp from pter
Size:
29,565 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TXND5_HUMAN, Q8NBS9 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 5 precursor  
Size: 432 amino acids; 47629 Da
Subcellular location: Endoplasmic reticulum lumen (By similarity)
Sequence caution: Sequence=AAH01199.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for TXNDC5:
2DIZ (3D)        3UJ1 (3D)        3UVT (3D)    
Secondary accessions: B2RDM2 Q5TCQ0 Q8ND33 Q8TCT2 Q9BVH9
Alternative splicing: 2 isoforms:  Q8NBS9-1   Q8NBS9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TXNDC5: NX_Q8NBS9

Explore proteomics data for TXNDC5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NBS9

  • TXNDC5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TXNDC5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001139021.1  NP_110437.2  

    ENSEMBL proteins: 
     ENSP00000369081   ENSP00000420784  
    Reactome Protein details: Q8NBS9
    Human Recombinant Protein Products for TXNDC5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TXNDC5
    OriGene Protein Over-expression Lysate for TXNDC5
    OriGene MassSpec for TXNDC5 
    OriGene Custom Protein Services for TXNDC5
    GenScript Custom Purified and Recombinant Proteins Services for TXNDC5
    Novus Biologicals TXNDC5 Protein
    Novus Biologicals TXNDC5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TXNDC5 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS16130169
    GO:0005788endoplasmic reticulum lumen IEA--
    GO:0043202lysosomal lumen TAS--

    TXNDC5 for ontologies           About GeneDecksing



    TXNDC5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TXNDC5
    OriGene Antibodies for TXNDC5
    OriGene Custom Antibody Services for TXNDC5
    GenScript Custom Superior Antibodies Services for TXNDC5
    Novus Biologicals TXNDC5 Antibodies
    Abcam antibodies for TXNDC5
    Cloud-Clone Corp. Antibodies for TXNDC5 
    ThermoFisher Antibodies for TXNDC5
    LSBio Antibodies in human, mouse, rat for TXNDC5 

    Assay Products for TXNDC5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TXNDC5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TXNDC5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TXNDC5 
    Cloud-Clone Corp. CLIAs for TXNDC5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PDI: Protein disulfide isomerases

    5 InterPro protein domains:
     IPR005788 Disulphide_isomerase
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS
     IPR005746 Thioredoxin
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8NBS9

    ProtoNet protein and cluster: Q8NBS9

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TXND5_HUMAN, Q8NBS9
    Similarity: Belongs to the protein disulfide isomerase family
    Similarity: Contains 3 thioredoxin domains


    TXNDC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXND5_HUMAN, Q8NBS9
    Function: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements
    protein disulfide-isomerase deficiency in yeast (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0016853isomerase activity IEA--
         
    TXNDC5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TXNDC5:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TXNDC5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TXNDC5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TXNDC5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TXNDC5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNDC5
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNDC5 (see all 46):
    hsa-miR-300 hsa-miR-485-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-218 hsa-miR-371-5p hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidTXNDC5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TXNDC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNDC5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TXNDC5
    Sirion Biotech Customized adenovirus for overexpression of TXNDC5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TXNDC5 (see all 14)
    OriGene ORF clones in mouse, rat for TXNDC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TXNDC5 (NM_030810)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNDC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC5
    Sirion Biotech Customized lentivirus for stable overexpression of TXNDC5 
                         Customized lentivirus expression plasmids for stable overexpression of TXNDC5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TXNDC5
    Search LifeMap BioReagents cell lines for TXNDC5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TXNDC5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Lysosome Vesicle Biogenesis0.39
    2Membrane Trafficking
    Membrane Trafficking0.32
    3Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for TXNDC5
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding
    Lysosome Vesicle Biogenesis


    1         Kegg Pathway  (Kegg details for TXNDC5):
        Protein processing in endoplasmic reticulum


    TXNDC5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TXNDC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/24 Interacting proteins for TXNDC5 (Q8NBS92, 3 ENSP000003690814) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRDX4Q131622, 3, ENSP000003686464MINT-8090275 MINT-8090993 I2D: score=1 STRING: ENSP00000368646
    H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
    YOD1Q5VVQ63, ENSP000003268134I2D: score=1 STRING: ENSP00000326813
    AP1M1ENSP000003889964STRING: ENSP00000388996
    AP1S2ENSP000003287894STRING: ENSP00000328789
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006662glycerol ether metabolic process IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0043066negative regulation of apoptotic process TAS16130169
    GO:0045454cell redox homeostasis IEA--

    TXNDC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TXNDC5 (TXND5)

    Search CenterWatch for drugs/clinical trials and news about TXNDC5 / TXND5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TXNDC5 gene (3 alternative transcripts): 
    NM_001145549.2  NM_030810.3  NM_022085.3  

    Unigene Cluster for TXNDC5:

    Thioredoxin domain containing 5 (endoplasmic reticulum)
    Hs.150837  [show with all ESTs]
    Unigene Representative Sequence: NR_037616
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460138 ENST00000379757(uc003mxv.3 uc010joa.2) ENST00000473453
    ENST00000475802 ENST00000469459
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNDC5
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNDC5 (see all 46):
    hsa-miR-300 hsa-miR-485-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-218 hsa-miR-371-5p hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidTXNDC5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TXNDC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNDC5
    Clone
    Products:
         
    OriGene clones in human, mouse for TXNDC5 (see all 14)
    OriGene ORF clones in mouse, rat for TXNDC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TXNDC5 (NM_030810)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNDC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC5
    Sirion Biotech Customized lentivirus for stable overexpression of TXNDC5 
                         Customized lentivirus expression plasmids for stable overexpression of TXNDC5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TXNDC5
    OriGene qSTAR qPCR primer pairs in human, mouse for TXNDC5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXNDC5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC5

    Additional mRNA sequence: 

    AJ440721.1 AK075291.1 AK098089.1 AK315598.1 AL833008.1 AL834423.1 AY326464.1 AY358646.1 
    BC001199.1 BC003529.1 NR_037616.1 

    24/32 DOTS entries (see all 32):

    DT.100877421  DT.100877424  DT.100877441  DT.91771572  DT.454688  DT.91771556  DT.121351902  DT.100650095 
    DT.121351933  DT.91771557  DT.100877435  DT.100877420  DT.100877434  DT.121351906  DT.100711432  DT.121351835 
    DT.91996705  DT.100716089  DT.100832803  DT.121351874  DT.121351901  DT.121351931  DT.121352021  DT.91771558 

    24/1254 AceView cDNA sequences (see all 1254):

    BU185442 BE254196 AA777198 CB104888 AA843714 CA423837 BU542424 BQ181185 
    BU542001 BU931711 NM_201280 AA557268 AI810997 BU190882 BQ683614 AA825197 
    BQ957238 BQ888963 AA573738 BG821564 BE737664 AW151491 BM759070 BE741557 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TXNDC5 expression in normal human tissues (normalized intensities)      TXNDC5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTCCTTGT
    TXNDC5 Expression
    About this image


    TXNDC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Human Pulmonary Artery Endothelial Cells (HPAEC)   
     
     Umbilical Cord (Extraembryonic Tissues)
             Human Umbilical Artery Endothelial Cells (HUAEC)   
     
     Heart (Cardiovascular System)
             Human Pulmonary Artery Endothelial Cells (HPAEC)   
     
     Placenta (Extraembryonic Tissues)
             Placenta Pericyte   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)

    See TXNDC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TXNDC5

    SOURCE GeneReport for Unigene cluster: Hs.150837
        SABiosciences Custom PCR Arrays for TXNDC5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TXNDC5
    OriGene qSTAR qPCR primer pairs in human, mouse for TXNDC5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXNDC5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TXNDC5 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txndc51 , 5 thioredoxin domain containing 51, 5 86.25(n)1
    86.81(a)1
      13 (18.27 cM)5
    1052451  NM_145367.31  NP_663342.31 
     385002735 
    chicken
    (Gallus gallus)
    Aves TXNDC51 thioredoxin domain containing 5 (endoplasmic reticulum) 72.9(n)
    71.72(a)
      420867  NM_001006374.1  NP_001006374.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    66(a)
    1 → many
    GL343209.1(882795-911967)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045245.12   -- 76.01(n)    BC045245.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.254202 Danio rerio cDNA clone MGC66265 IMAGE5410287, complete more 76.05(n)    BC057499.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta prtp1 pretaporter 54.33(n)
    46.61(a)
      32124  NM_001201654.1  NP_001188583.1 


    ENSEMBL Gene Tree for TXNDC5 (if available)
    TreeFam Gene Tree for TXNDC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TXNDC5 gene
    DNAJC102  PDIA62  BLOC1S5-TXNDC52  PDIA52  
    4 SIMAP similar genes for TXNDC5 using alignment to 2 protein entries:     TXND5_HUMAN (see all proteins):
    DKFZp666I134    STRF8    PDIA6    TXN

    TXNDC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TXNDC5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731544CNV Deletion23290073
    nsv462625CNV Loss19166990
    nsv830582CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TXNDC5
    DNA2.0 Custom Variant and Variant Library Synthesis for TXNDC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    10 diseases for TXNDC5:    About MalaCards
    hypoxia    vitiligo    endotheliitis    insulin resistance
    adenoma    schizophrenia    gastric cancer    arthritis
    hepatocellular carcinoma    hepatitis


    TXNDC5 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TXNDC5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 12963716 (2), 14607843 (1)

    Genetic Association Database (GAD): TXNDC5
    Human Genome Epidemiology (HuGE) Navigator: TXNDC5 (6 documents)

    Export disorders for TXNDC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TXNDC5 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with TXNDC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of TXNDC5 gene polymorphisms and suscepti bility to nonsegmental vitiligo in the Korean population. (PubMed id 19906073)1, 4, 9 Jeong K.H....Lee M.H. (2009)
    2. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (2009)
    3. Clustering by neurocognition for fine mapping of the schizophrenia susceptibility loci on chromosome 6p. (PubMed id 19694819)1, 4 Lin S.H....Chen W.J. (2009)
    4. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor. (PubMed id 12963716)1, 9 Sullivan D.C....Bicknell R. (2003)
    10. Protein disulphide isomerase family members show dist inct substrate specificity: P5 is targeted to BiP client proteins. (PubMed id 19887585)1, 9 Jessop C.E....Bulleid N.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81567 HGNC: 21073 AceView: EEF1E1 Ensembl:ENSG00000239264 euGenes: HUgn81567
    ECgene: TXNDC5 Kegg: 81567 H-InvDB: TXNDC5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TXNDC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TXNDC5 gene:
    Search GeneIP for patents involving TXNDC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for TXNDC5 (TXNDC5)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TXNDC5   OriGene RNAi products in human, mouse, rat for TXNDC5  
     OriGene qPCR primer pairs and template standards for TXNDC5   OriGene Protein Over-expression Lysate for TXNDC5  
     OriGene MassSpec something-or-other for TXNDC5   OriGene clones in human, mouse for TXNDC5  
     OriGene qSTAR qPCR primer pairs in human, mouse for TXNDC5   OriGene Purified Protein for TXNDC5  
     OriGene ORF clones in mouse, rat for TXNDC5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TXNDC5   OriGene Custom Protein Services for TXNDC5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TXNDC5
     QIAGEN SeqTarget long-range PCR primers for resequencing TXNDC5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNDC5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC5
     GenScript Custom Purified and Recombinant Proteins Services for TXNDC5 GenScript cDNA clones with any tag delivered in your preferred vector for TXNDC5
     GenScript Custom Assay Services for TXNDC5 GenScript Custom Superior Antibodies Services for TXNDC5
     GenScript Custom overexpressing Cell Line Services for TXNDC5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TXNDC5 promoter
     Search Chromatin IP Primers for TXNDC5
     RT2 qPCR Primer Assay in human, mouse, rat TXNDC5
     Search GNC Networks for TXNDC5
     SABiosciences Custom PCR Arrays for TXNDC5
     Search Tocris compounds for TXNDC5 (TXND5)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TXNDC5 antibodies
     TXNDC5 proteins
     TXNDC5 lysates
     Antibodies for TXNDC5
     See all of Abcam's Antibodies, Kits and Proteins for TXNDC5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TXNDC5
     Antibodies for TXNDC5
     ELISAs for TXNDC5
     CLIAs for TXNDC5
     Search LifeMap BioReagents cell lines for TXNDC5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC5
     SwitchGear 3'UTR luciferase reporter plasmids for TXNDC5
     SwitchGear Promoter luciferase reporter plasmids for TXNDC5
     ThermoFisher Antibodies for TXNDC5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TXNDC5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TXNDC5
    Customized:
     lentivirus for stable overexpression of TXNDC5
     lentivirus expression plasmids for stable overexpression of TXNDC5
     adenovirus for overexpression of TXNDC5
     LSBio Antibodies in human, mouse, rat for TXNDC5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TXNDC5 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4