Aliases for TXNDC5 Gene
Aliases for TXNDC5 Gene
- Thioredoxin Domain Containing 5 2 3 5
- Protein Disulfide Isomerase Family A, Member 15 2 3
- Endoplasmic Reticulum Resident Protein 46 3 4
- Thioredoxin-Like Protein P46 3 4
- ER Protein 46 3 4
- ERP46 3 4
- Thioredoxin Domain Containing 5 (Endoplasmic Reticulum) 3
- Endothelial Protein Disulphide Isomerase 3
- Thioredoxin Domain-Containing Protein 5 3
- Endoplasmic Reticulum Protein ERp46 3
External Ids for TXNDC5 Gene
- HGNC: 21073
- Entrez Gene: 81567
- Ensembl: ENSG00000239264
- OMIM: 616412
- UniProtKB: Q8NBS9
Previous GeneCards Identifiers for TXNDC5 Gene
- GC06M007871
- GC06M007826
Summaries for TXNDC5 Gene
-
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]
GeneCards Summary for TXNDC5 Gene
TXNDC5 (Thioredoxin Domain Containing 5) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Innate Immune System. Gene Ontology (GO) annotations related to this gene include isomerase activity and protein disulfide isomerase activity. An important paralog of this gene is DNAJC10.
UniProtKB/Swiss-Prot for TXNDC5 Gene
-
Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).
Additional gene information for TXNDC5 Gene
- Monarch Initiative
- Search for TXNDC5 at DataMed
- Search for TXNDC5 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC5 Gene
Genomics for TXNDC5 Gene
GeneHancer (GH) Regulatory Elements for TXNDC5 Gene
Promoters and enhancers for TXNDC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TXNDC5 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TXNDC5 Gene
Genomic Locations for TXNDC5 Gene
- chr6:7,881,250-7,910,814
- (GRCh38/hg38)
- Size:
- 29,565 bases
- Orientation:
- Minus strand
- chr6:7,881,483-8,026,646
- (GRCh37/hg19)
Genomic View for TXNDC5 Gene
Genes around TXNDC5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p24.3 by Ensembl
- 6p24.3 by Entrez Gene
- 6p24.3 by HGNC
TXNDC5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TXNDC5 Gene
Proteins for TXNDC5 Gene
-
Protein details for TXNDC5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NBS9-TXND5_HUMAN
- Recommended name:
- Thioredoxin domain-containing protein 5
- Protein Accession:
- Q8NBS9
- B2RDM2
- Q5TCQ0
- Q8ND33
- Q8TCT2
- Q9BVH9
Protein attributes for TXNDC5 Gene
- Size:
- 432 amino acids
- Molecular mass:
- 47629 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH01199.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for TXNDC5 Gene
Protein Expression for TXNDC5 Gene
Post-translational modifications for TXNDC5 Gene
Other Protein References for TXNDC5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TXNDC5 (TXNDC5)
- Novus Biologicals Antibodies for TXNDC5
-
Abcam antibodies for TXNDC5
- Invitrogen Antibodies for TXNDC5
- GeneTex TXNDC5 antibody for TXNDC5
-
Santa Cruz Biotechnology (SCBT) Antibodies for TXNDC5
Protein Products
-
OriGene Purified Proteins for TXNDC5
- Search Origene for MassSpec and Protein Over-expression Lysates for TXNDC5
- Origene Custom Protein Services for TXNDC5
- Search GeneTex for Proteins for TXNDC5
-
Abcam proteins for TXNDC5
Assay Products
No data available for DME Specific Peptides for TXNDC5 Gene
Domains & Families for TXNDC5 Gene
Gene Families for TXNDC5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for TXNDC5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TXNDC5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NBS9- Family:
-
- Belongs to the protein disulfide isomerase family.
Function for TXNDC5 Gene
Molecular function for TXNDC5 Gene
- UniProtKB/Swiss-Prot Function:
- Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).
Phenotypes From GWAS Catalog for TXNDC5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003756 | protein disulfide isomerase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 21057456 |
| GO:0016853 | isomerase activity | IEA | -- |
Phenotypes for TXNDC5 Gene
- MGI mutant phenotypes for TXNDC5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TXNDC5:
Animal Models for TXNDC5 Gene
- MGI Knock Outs for TXNDC5:
-
- Txndc5 tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for TXNDC5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TXNDC5 gene
- Search ViGene Biosciences for TXNDC5
CRISPR Products
-
OriGene CRISPR knockouts for TXNDC5
- genomics-online: gRNA clones - Search results for 88 available TXNDC5 gene related products
- Overview of 88 available TXNDC5 gene related products
- Applied Biological Materials CRISPR for TXNDC5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TXNDC5
- GenScript: Design CRISPR guide RNA sequences for TXNDC5
miRNA for TXNDC5 Gene
- miRTarBase miRNAs that target TXNDC5
-
- hsa-mir-505-5p (MIRT037960)
- hsa-mir-196b-5p (MIRT042668)
- hsa-mir-31-5p (MIRT049868)
- hsa-mir-27b-3p (MIRT451840)
- hsa-mir-27a-3p (MIRT451841)
- hsa-mir-513a-5p (MIRT451842)
- hsa-mir-1199-3p (MIRT451843)
- hsa-mir-6806-3p (MIRT451844)
- hsa-mir-3928-5p (MIRT451845)
- hsa-mir-6761-5p (MIRT451846)
- hsa-mir-766-3p (MIRT451847)
- hsa-mir-342-3p (MIRT451848)
- hsa-mir-4530 (MIRT451849)
- hsa-mir-216b-3p (MIRT451850)
- hsa-mir-503-5p (MIRT451851)
- hsa-mir-3120-3p (MIRT451852)
- hsa-mir-30e-5p (MIRT726203)
- hsa-mir-30d-5p (MIRT726204)
- hsa-mir-30b-5p (MIRT726205)
- hsa-mir-30c-5p (MIRT726206)
- hsa-mir-30a-5p (MIRT726207)
miRNA Products
- Search ViGene Biosciences for TXNDC5
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TXNDC5
- Browse OriGene Inhibitory RNA Products For TXNDC5
- genomics-online: shRNA clones - Search results for 88 available TXNDC5 gene related products
- Overview of 88 available TXNDC5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TXNDC5 gene
Clone Products
- Sino Biological Human cDNA Clone for TXNDC5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for TXNDC5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TXNDC5
-
ViGene Biosciences adenoviral particle packaged cDNA for TXNDC5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TXNDC5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TXNDC5 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TXNDC5 Gene
Localization for TXNDC5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TXNDC5 Gene
- Endoplasmic reticulum lumen.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| lysosome | 5 |
| cytosol | 3 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| golgi apparatus | 1 |
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005623 | cell | IEA | -- |
| GO:0005783 | endoplasmic reticulum | TAS | 16130169 |
| GO:0005788 | endoplasmic reticulum lumen | IEA | -- |
| GO:0035578 | azurophil granule lumen | TAS | -- |
Pathways & Interactions for TXNDC5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Clathrin derived vesicle budding | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Vesicle-mediated transport | ||
| 4 | Protein processing in endoplasmic reticulum | ||
Pathways by source for TXNDC5 Gene
9 Reactome pathways for TXNDC5 Gene
1 KEGG pathway for TXNDC5 Gene
Interacting Proteins for TXNDC5 Gene
Selected Interacting proteins:
ENSP00000369081
Q8NBS9-TXND5_HUMAN
for TXNDC5 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | IBA | -- |
| GO:0034976 | response to endoplasmic reticulum stress | IBA | -- |
| GO:0043066 | negative regulation of apoptotic process | TAS | 16130169 |
| GO:0043277 | apoptotic cell clearance | IBA | -- |
| GO:0043312 | neutrophil degranulation | TAS | -- |
No data available for SIGNOR curated interactions for TXNDC5 Gene
Transcripts for TXNDC5 Gene
mRNA/cDNA for TXNDC5 Gene
- (3) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (1254) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TXNDC5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TXNDC5
- genomics-online: gRNA clones - Search results for 88 available TXNDC5 gene related products
- Overview of 88 available TXNDC5 gene related products
- Applied Biological Materials CRISPR for TXNDC5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TXNDC5
- GenScript: Design CRISPR guide RNA sequences for TXNDC5
miRNA Products
- Search ViGene Biosciences for TXNDC5
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TXNDC5
- Browse OriGene Inhibitory RNA Products For TXNDC5
- genomics-online: shRNA clones - Search results for 88 available TXNDC5 gene related products
- Overview of 88 available TXNDC5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TXNDC5 gene
Clone Products
- Sino Biological Human cDNA Clone for TXNDC5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for TXNDC5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TXNDC5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
-
Umbilical Cord (Extraembryonic Tissues)
This gene is overexpressed in Oral epithelium (11.3) and Tonsil (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXNDC5 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TXNDC5 Gene:
TXNDC5SOURCE GeneReport for Unigene cluster for TXNDC5 Gene:
Hs.150837Evidence on tissue expression from TISSUES for TXNDC5 Gene
- Lung(4.8)
- Liver(4.7)
- Eye(4.6)
- Lymph node(4.4)
- Skin(4.3)
- Intestine(4)
- Pancreas(3.4)
- Nervous system(3.3)
- Kidney(3.1)
- Heart(2.5)
- Bone(2.3)
- Blood(2.2)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs for TXNDC5
-
OriGene qPCR primer pairs and template standards for TXNDC5
- genomics-online: primer clones - Search results for 88 available TXNDC5 gene related products
- Overview of 88 available TXNDC5 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNDC5 Gene
Orthologs for TXNDC5 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TXNDC5 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Txndc5 33 16 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TXNDC5 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Txndc5 33 |
|
||
| cow (Bos Taurus) |
Mammalia | TXNDC5 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TXNDC5 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TXNDC5 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TXNDC5 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TXNDC5 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | txndc5 33 |
|
||
| MGC75894 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | txndc5 33 34 |
|
||
| Dr.25420 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | prtp 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000044 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MPD1 34 |
|
OneToMany | |
| EPS1 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2468 33 |
|
- Species where no ortholog for TXNDC5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TXNDC5 Gene
(4) SIMAP similar genes for TXNDC5 Gene using alignment to 2 proteins:
Variants for TXNDC5 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000068689 | -- | 7,903,909(-) | C/G | intron_variant | |
| rs1000137385 | -- | 7,893,124(-) | A/G | intron_variant | |
| rs1000328051 | -- | 7,892,554(-) | T/C | intron_variant | |
| rs1000436882 | -- | 7,887,730(-) | C/T | intron_variant | |
| rs1000476100 | -- | 7,908,934(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2731544 | CNV | deletion | 23290073 |
| esv3890787 | CNV | loss | 25118596 |
| nsv1133014 | OTHER | inversion | 24896259 |
| nsv1145091 | CNV | deletion | 24896259 |
| nsv1151332 | OTHER | inversion | 26484159 |
| nsv462625 | CNV | loss | 19166990 |
| nsv600924 | CNV | gain | 21841781 |
| nsv600925 | CNV | loss | 21841781 |
| nsv830582 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.40;
42.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TXNDC5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TXNDC5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC5 Gene
Disorders for TXNDC5 Gene
Additional Disease Information for TXNDC5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TXNDC5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC5 Gene
Publications for TXNDC5 Gene
- Association of TXNDC5 gene polymorphisms and susceptibility to nonsegmental vitiligo in the Korean population. (PMID: 19906073) Jeong KH … Lee MH (The British journal of dermatology 2010) 3 22 44 58
- Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So HC … Sham PC (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
- Clustering by neurocognition for fine mapping of the schizophrenia susceptibility loci on chromosome 6p. (PMID: 19694819) Lin SH … Chen WJ (Genes, brain, and behavior 2009) 3 44 58
- Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
- Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins. (PMID: 19887585) Jessop CE … Bulleid NJ (Journal of cell science 2009) 3 22 58
Products for TXNDC5 Gene
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- Invitrogen Antibodies for TXNDC5
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- antibodies-online: Search results for 165 available TXNDC5 Antibodies ranked by validation data
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- GeneTex TXNDC5 antibody for TXNDC5
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- ViGene Biosciences adenoviral particle packaged cDNA for TXNDC5 gene
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- genomics-online: cdna clones - Search results for 88 available TXNDC5 gene related products
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- Overview of 88 available TXNDC5 gene related products
Sources for TXNDC5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
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