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TXNDC5 Gene

protein-coding   GIFtS: 58
GCID: GC06M007826

Thioredoxin Domain Containing 5 (Endoplasmic Reticulum)

(Previous name: thioredoxin domain containing 5)
  See TXNDC5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin Domain Containing 5 (Endoplasmic Reticulum)1 2     PDIA152
Endoplasmic Reticulum Resident Protein 462 3     STRF82
Thioredoxin-Like Protein P462 3     UNQ3642
ER Protein 462 3     Endoplasmic Reticulum Protein ERp462
Member 151     Endothelial Protein Disulphide Isomerase2
Protein Disulfide Isomerase Family A1     Protein Disulfide Isomerase Family A, Member 152
Thioredoxin Domain Containing 51     Thioredoxin Domain-Containing Protein 52
ENDOPDI2     Thioredoxin Related Protein2
ERP462     ERp463
HCC-22     TLP463

External Ids:    HGNC: 210731   Entrez Gene: 815672   Ensembl: ENSG000002392647   UniProtKB: Q8NBS93   

Export aliases for TXNDC5 gene to outside databases

Previous GC identifer: GC06M007871


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TXNDC5 Gene:
This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to
protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through
transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. (provided by
RefSeq, Dec 2010)

GeneCards Summary for TXNDC5 Gene:
TXNDC5 (thioredoxin domain containing 5 (endoplasmic reticulum)) is a protein-coding gene. Diseases associated with TXNDC5 include hypoxia. GO annotations related to this gene include isomerase activity and electron carrier activity. An important paralog of this gene is DNAJC10.

UniProtKB/Swiss-Prot: TXND5_HUMAN, Q8NBS9
Function: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements
protein disulfide-isomerase deficiency in yeast (By similarity)

Gene Wiki entry for TXNDC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TXNDC5 gene promoter:
         Nkx3-1   Nkx3-1 v2   Nkx3-1 v3   Nkx3-1 v1   E4BP4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TXNDC5 promoter sequence
   Search Chromatin IP Primers for TXNDC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXNDC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.3   Ensembl cytogenetic band:  6p24.3   HGNC cytogenetic band: 6p24.3

TXNDC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNDC5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M007826:  view genomic region     (about GC identifiers)

Start:
7,881,483 bp from pter      End:
8,026,646 bp from pter
Size:
145,164 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TXND5_HUMAN, Q8NBS9 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 5 precursor  
Size: 432 amino acids; 47629 Da
Sequence caution: Sequence=AAH01199.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for TXNDC5:
2DIZ (3D)        3UJ1 (3D)        3UVT (3D)    
Secondary accessions: B2RDM2 Q5TCQ0 Q8ND33 Q8TCT2 Q9BVH9
Alternative splicing: 2 isoforms:  Q8NBS9-1   Q8NBS9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TXNDC5: NX_Q8NBS9

Explore proteomics data for TXNDC5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys113, Lys150
  • Glycosylation2 at Thr72
  • Modification sites at PhosphoSitePlus

  • See TXNDC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139021.1  NP_110437.2  

    ENSEMBL proteins: 
     ENSP00000369081   ENSP00000420784   ENSP00000442453  
    Reactome Protein details: Q8NBS9

    TXNDC5 Human Recombinant Protein Products:

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    antibodies-online peptides for TXNDC5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PDI: Protein disulfide isomerases

    5 InterPro protein domains:
     IPR005746 Thioredoxin
     IPR012336 Thioredoxin-like_fold
     IPR005788 Disulphide_isomerase
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS

    Graphical View of Domain Structure for InterPro Entry Q8NBS9

    ProtoNet protein and cluster: Q8NBS9

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TXND5_HUMAN, Q8NBS9
    Similarity: Belongs to the protein disulfide isomerase family
    Similarity: Contains 3 thioredoxin domains


    Find genes that share domains with TXNDC5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXND5_HUMAN, Q8NBS9
    Function: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements
    protein disulfide-isomerase deficiency in yeast (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity IBA--
    GO:0005515protein binding IPI--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0016853isomerase activity ----
         
    Find genes that share ontologies with TXNDC5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TXNDC5:
     Decreased viability 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TXNDC5

    miRNA
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    miRTarBase miRNAs that target TXNDC5:
    hsa-mir-196b-5p (MIRT042668), hsa-mir-31-5p (MIRT049868), hsa-mir-505-5p (MIRT037960)

    Block miRNA regulation of human, mouse, rat TXNDC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TXNDC5 (see all 46):
    hsa-miR-300 hsa-miR-485-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-218 hsa-miR-371-5p hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidTXNDC5 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TXND5_HUMAN, Q8NBS9: Endoplasmic reticulum lumen (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    lysosome4
    vacuole4
    extracellular2
    cytosol1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS16130169
    GO:0005788endoplasmic reticulum lumen IEA--
    GO:0043202lysosomal lumen TAS--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with TXNDC5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TXNDC5 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    Lysosome Vesicle Biogenesis0.41
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32
    trans-Golgi Network Vesicle Budding0.89
    2Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with TXNDC5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for TXNDC5
        Golgi Associated Vesicle Biogenesis
    Lysosome Vesicle Biogenesis


    1 Kegg Pathway  (Kegg details for TXNDC5):
        Protein processing in endoplasmic reticulum

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TXNDC5
    Interactions:

        Search GeneGlobe Interaction Network for TXNDC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TXNDC5 (Q8NBS91, 2, 3 ENSP000003690814) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRDX4Q131621, 2, 3, ENSP000003686464EBI-2510815,EBI-2211957 MINT-8090275 MINT-8090993 I2D: score=1 STRING: ENSP00000368646
    H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
    YOD1Q5VVQ63, ENSP000003268134I2D: score=1 STRING: ENSP00000326813
    AP1M1ENSP000003889964STRING: ENSP00000388996
    AP1S2ENSP000003287894STRING: ENSP00000328789
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IBA--
    GO:0006662glycerol ether metabolic process IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0034976response to endoplasmic reticulum stress IBA--
    GO:0043066negative regulation of apoptotic process TAS16130169

    Find genes that share ontologies with TXNDC5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TXNDC5 (TXND5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TXNDC5 gene (3 alternative transcripts): 
    NM_001145549.2  NM_030810.3  NM_022085.3  

    Unigene Cluster for TXNDC5:

    Thioredoxin domain containing 5 (endoplasmic reticulum)
    Hs.150837  [show with all ESTs]
    Unigene Representative Sequence: NR_037616
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460138 ENST00000379757(uc003mxv.3 uc010joa.2) ENST00000473453
    ENST00000475802 ENST00000469459 ENST00000539054(uc010jnz.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat TXNDC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TXNDC5 (see all 46):
    hsa-miR-300 hsa-miR-485-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-218 hsa-miR-371-5p hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidTXNDC5 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat TXNDC5
      QuantiFast Probe-based Assays in human, mouse, rat TXNDC5

    Additional mRNA sequence: 

    AJ440721.1 AK075291.1 AK098089.1 AK315598.1 AL833008.1 AL834423.1 AY326464.1 AY358646.1 
    BC001199.1 BC003529.1 NR_037616.1 

    Selected DOTS entries (see all 32):

    DT.100877421  DT.100877424  DT.100877441  DT.91771572  DT.454688  DT.91771556  DT.121351902  DT.100650095 
    DT.121351933  DT.91771557  DT.100877435  DT.100877420  DT.100877434  DT.121351906  DT.100711432  DT.121351835 
    DT.91996705  DT.100716089  DT.100832803  DT.121351874  DT.121351901  DT.121351931  DT.121352021  DT.91771558 

    Selected AceView cDNA sequences (see all 1254):

    AI624578 AI571664 BQ677165 BQ776028 BQ678581 BU931711 AA653396 BU185442 
    BU542424 AA262233 CB104888 BE737664 BP338295 BU178039 BQ956454 W72030 
    BU190522 BU542233 BU196673 BQ962137 BQ920500 BQ677211 BQ901106 T17252 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TXNDC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTCCTTGT
    TXNDC5 Expression
    About this image


    TXNDC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Umbilical Cord (Extraembryonic Tissues)
    TXNDC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TXNDC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150837
        Custom PCR Arrays for TXNDC5
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TXNDC5 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txndc51 , 5 thioredoxin domain containing 51, 5 86.81(n)1
    89.57(a)1
      13 (18.27 cM)5
    1052451  NM_145367.31  NP_663342.31 
     385002735 
    chicken
    (Gallus gallus)
    Aves TXNDC51 thioredoxin domain containing 5 (endoplasmic reticulum) 74.53(n)
    74.53(a)
      420867  NM_001006374.1  NP_001006374.1 
    lizard
    (Anolis carolinensis)
    Reptilia TXNDC56
    thioredoxin domain containing 5 (endoplasmic retic...
    66(a)
    1 ↔ 1
    GL343209.1(882795-911967)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045245.12   -- 76.01(n)    BC045245.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.254202 Danio rerio cDNA clone MGC66265 IMAGE5410287, complete more 76.05(n)    BC057499.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta prtp1 pretaporter 54.83(n)
    47.16(a)
      32124  NM_132514.3  NP_572742.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EPS1(YIL005W)4 ER protein with chaperone and co-chaperone activity, more   --   9(345692-347797) 854812  NP_012261.1 


    ENSEMBL Gene Tree for TXNDC5 (if available)
    TreeFam Gene Tree for TXNDC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TXNDC5 gene
    DNAJC102  PDIA62  PDIA52  
    4 SIMAP similar genes for TXNDC5 using alignment to 2 protein entries:     TXND5_HUMAN (see all proteins):
    DKFZp666I134    STRF8    PDIA6    TXN

    Find genes that share paralogs with TXNDC5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TXNDC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731544CNV Deletion23290073
    nsv462625CNV Loss19166990
    nsv830582CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TXNDC5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TXNDC5:    
    About MalaCards
    hypoxia


    Find genes that share disorders with TXNDC5           About GenesLikeMe

    1 Novoseek inferred disease relationship for TXNDC5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 12963716 (2), 14607843 (1)

    Genetic Association Database (GAD): TXNDC5
    Human Genome Epidemiology (HuGE) Navigator: TXNDC5 (6 documents)

    Export disorders for TXNDC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TXNDC5 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with TXNDC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of TXNDC5 gene polymorphisms and susceptibility to nonsegmental vitiligo in the Korean population. (PubMed id 19906073)1, 4, 9 Jeong K.H....Lee M.H. (Br. J. Dermatol. 2010)
    2. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    4. Clustering by neurocognition for fine mapping of the schizophrenia susceptibility loci on chromosome 6p. (PubMed id 19694819)1, 4 Lin S.H....Chen W.J. (Genes Brain Behav. 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor. (PubMed id 12963716)1, 9 Sullivan D.C....Bicknell R. (J. Biol. Chem. 2003)
    10. Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins. (PubMed id 19887585)1, 9 Jessop C.E....Bulleid N.J. (J. Cell. Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81567 HGNC: 21073 AceView: EEF1E1 Ensembl:ENSG00000239264 euGenes: HUgn81567
    ECgene: TXNDC5 Kegg: 81567 H-InvDB: TXNDC5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TXNDC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TXNDC5 gene:
    Search GeneIP for patents involving TXNDC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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