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TXNDC5 Gene

protein-coding GIFtS: 58
GCID: GC06M007826

Thioredoxin Domain Containing 5 (Endoplasmic Reticulum)

(Previous name: thioredoxin domain containing 5)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Thioredoxin Domain Containing 5 (Endoplasmic Reticulum)¹ ²		PDIA15²
Endoplasmic Reticulum Resident Protein 46² ³		STRF8²
Thioredoxin-Like Protein P46² ³		UNQ364²
ER Protein 46² ³		Endoplasmic Reticulum Protein ERp46²
Member 15¹		Endothelial Protein Disulphide Isomerase²
Protein Disulfide Isomerase Family A¹		Protein Disulfide Isomerase Family A, Member 15²
Thioredoxin Domain Containing 5¹		Thioredoxin Domain-Containing Protein 5²
ENDOPDI²		Thioredoxin Related Protein²
ERP46²		ERp46³
HCC-2²		TLP46³

External Ids:	HGNC: 21073¹	Entrez Gene: 81567²	Ensembl: ENSG00000239264⁷	UniProtKB: Q8NBS9³

Export aliases for TXNDC5 gene to outside databases

Previous GC identifer: GC06M007871

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TXNDC5 Gene:

This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to

protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through

transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. (provided by

RefSeq, Dec 2010)

GeneCards Summary for TXNDC5 Gene:

TXNDC5 (thioredoxin domain containing 5 (endoplasmic reticulum)) is a protein-coding gene. Diseases associated with TXNDC5 include hypoxia, and vitiligo. GO annotations related to this gene include isomerase activity and electron carrier activity. An important paralog of this gene is DNAJC10.

UniProtKB/Swiss-Prot: TXND5_HUMAN, Q8NBS9

Function: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements

protein disulfide-isomerase deficiency in yeast (By similarity)

Gene Wiki entry for TXNDC5 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000006.12 NC_018917.2 NT_007592.16

Regulatory elements:

Regulatory transcription factor binding sites in the TXNDC5 gene promoter:
Nkx3-1 Nkx3-1 v2 Nkx3-1 v3 Nkx3-1 v1 E4BP4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TXNDC5 promoter sequence

Search Chromatin IP Primers for TXNDC5

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXNDC5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.3 Ensembl cytogenetic band: 6p24.3 HGNC cytogenetic band: 6p24.3

TXNDC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNDC5 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M007826: view genomic region (about GC identifiers)

Start:	7,881,483 bp from pter	End:	8,026,646 bp from pter
Size:	145,164 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TXND5_HUMAN, Q8NBS9 (See protein sequence)

Recommended Name: Thioredoxin domain-containing protein 5 precursor

Size: 432 amino acids; 47629 Da

Sequence caution: Sequence=AAH01199.1; Type=Erroneous initiation;

3 PDB 3D structures from and Proteopedia for TXNDC5:

2DIZ (3D)

3UJ1 (3D)

3UVT (3D)

Secondary accessions: B2RDM2 Q5TCQ0 Q8ND33 Q8TCT2 Q9BVH9

Alternative splicing: 2 isoforms: Q8NBS9-1 Q8NBS9-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TXNDC5: NX_Q8NBS9

Explore proteomics data for TXNDC5 at MOPED

Post-translational modifications:

Ubiquitination² at Lys113, Lys150

Glycosylation² at Thr72

Modification sites at PhosphoSitePlus

See TXNDC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001139021.1 NP_110437.2

ENSEMBL proteins:

ENSP00000369081 ENSP00000420784 ENSP00000442453

Reactome Protein details: Q8NBS9

TXNDC5 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

PDI: Protein disulfide isomerases

5 InterPro protein domains:

IPR005746 Thioredoxin

IPR012336 Thioredoxin-like_fold

IPR005788 Disulphide_isomerase

IPR013766 Thioredoxin_domain

IPR017937 Thioredoxin_CS

Graphical View of Domain Structure for InterPro Entry Q8NBS9

ProtoNet protein and cluster: Q8NBS9

1 Blocks protein domain: IPB006662 Thioredoxin type domain

UniProtKB/Swiss-Prot: TXND5_HUMAN, Q8NBS9

Similarity: Belongs to the protein disulfide isomerase family

Similarity: Contains 3 thioredoxin domains

TXNDC5 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TXND5_HUMAN, Q8NBS9

Function: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements

protein disulfide-isomerase deficiency in yeast (By similarity)

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003756	protein disulfide isomerase activity	IBA	--
GO:0005515	protein binding	IPI	--
GO:0015035	protein disulfide oxidoreductase activity	IEA	--
GO:0016853	isomerase activity	--	--

TXNDC5 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TXNDC5:

Decreased viability

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TXNDC5

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miRNA Products:		miRTarBase miRNAs that target TXNDC5: hsa-mir-196b-5p (MIRT042668), hsa-mir-31-5p (MIRT049868), hsa-mir-505-5p (MIRT037960)

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		Selected qRT-PCR Assays for microRNAs that regulate TXNDC5 (see all 46):
		hsa-miR-300 hsa-miR-485-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-218 hsa-miR-371-5p hsa-miR-548l

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC5

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TXND5_HUMAN, Q8NBS9: Endoplasmic reticulum lumen (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endoplasmic reticulum	5
lysosome	4
vacuole	4
extracellular	2
cytosol	1
golgi apparatus	1
mitochondrion	1
plasma membrane	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	TAS	16130169
GO:0005788	endoplasmic reticulum lumen	IEA	--
GO:0043202	lysosomal lumen	TAS	--
GO:0070062	extracellular vesicular exosome	IDA	19199708

TXNDC5 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TXNDC5 About

See pathways by source

SuperPath

Contained pathways About

Clathrin derived vesicle budding

Clathrin derived vesicle budding	0.89	Lysosome Vesicle Biogenesis	0.41
Golgi Associated Vesicle Biogenesis	0.89	Membrane Trafficking	0.32
trans-Golgi Network Vesicle Budding	0.89

Protein processing in endoplasmic reticulum

Protein processing in endoplasmic reticulum

Pathways by source See SuperPaths
Show all pathways

2 Reactome Pathways for TXNDC5

	Golgi Associated Vesicle Biogenesis
	Lysosome Vesicle Biogenesis

1 Kegg Pathway (Kegg details for TXNDC5):

Protein processing in endoplasmic reticulum

TXNDC5 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for TXNDC5
Interactions:

Search GeneGlobe Interaction Network for TXNDC5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TXNDC5 (Q8NBS9^{1, 2, 3} ENSP00000369081⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRDX4	Q13162¹^,²^,³, ENSP00000368646⁴	EBI-2510815,EBI-2211957 MINT-8090275 MINT-8090993 I2D: score=1 STRING: ENSP00000368646
H2AFX	P16104³, ENSP00000364310⁴	I2D: score=1 STRING: ENSP00000364310
YOD1	Q5VVQ6³, ENSP00000326813⁴	I2D: score=1 STRING: ENSP00000326813
AP1M1	ENSP00000388996⁴	STRING: ENSP00000388996
AP1S2	ENSP00000328789⁴	STRING: ENSP00000328789

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Gene Ontology (GO): Selected biological process terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006457	protein folding	IBA	--
GO:0006662	glycerol ether metabolic process	IEA	--
GO:0006892	post-Golgi vesicle-mediated transport	TAS	--
GO:0034976	response to endoplasmic reticulum stress	IBA	--
GO:0043066	negative regulation of apoptotic process	TAS	16130169

TXNDC5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TXNDC5 (TXND5)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TXNDC5 gene (3 alternative transcripts):

NM_001145549.2 NM_030810.3 NM_022085.3

Unigene Cluster for TXNDC5:

Thioredoxin domain containing 5 (endoplasmic reticulum)

Hs.150837 [show with all ESTs]

Unigene Representative Sequence: NR_037616

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000460138 ENST00000379757(uc003mxv.3 uc010joa.2) ENST00000473453

ENST00000475802 ENST00000469459 ENST00000539054(uc010jnz.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat TXNDC5 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TXNDC5 (see all 46):
		hsa-miR-300 hsa-miR-485-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-218 hsa-miR-371-5p hsa-miR-548l

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Additional mRNA sequence:

AJ440721.1 AK075291.1 AK098089.1 AK315598.1 AL833008.1 AL834423.1 AY326464.1 AY358646.1

BC001199.1 BC003529.1 NR_037616.1

Selected DOTS entries (see all 32):

DT.100877421 DT.100877424 DT.100877441 DT.91771572 DT.454688 DT.91771556 DT.121351902 DT.100650095

DT.121351933 DT.91771557 DT.100877435 DT.100877420 DT.100877434 DT.121351906 DT.100711432 DT.121351835

DT.91996705 DT.100716089 DT.100832803 DT.121351874 DT.121351901 DT.121351931 DT.121352021 DT.91771558

Selected AceView cDNA sequences (see all 1254):

AI624578 AI571664 BQ677165 BQ776028 BQ678581 BU931711 AA653396 BU185442

BU542424 AA262233 CB104888 BE737664 BP338295 BU178039 BQ956454 W72030

BU190522 BU542233 BU196673 BQ962137 BQ920500 BQ677211 BQ901106 T17252

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TXNDC5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTGTCCTTGT

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TXNDC5 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Inner Cell Mass (Early Embryonic Tissues) fully expand to see all 2 entries
Human embryonic stem cells (family)

Blood (Hematopoietic System)
Mature B-Cells Peripheral Blood

Umbilical Cord (Extraembryonic Tissues)

TXNDC5 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TXNDC5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.150837

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for TXNDC5 gene from Selected species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Txndc5^{1 , 5}	thioredoxin domain containing 5^{1, 5}	86.81(n)¹ 89.57(a)¹		13 (18.27 cM)⁵ 105245¹ NM_145367.3¹ NP_663342.3¹ 38500273⁵
chicken (Gallus gallus)	Aves	TXNDC5¹	thioredoxin domain containing 5 (endoplasmic reticulum)	74.53(n) 74.53(a)		420867 NM_001006374.1 NP_001006374.1
lizard (Anolis carolinensis)	Reptilia	TXNDC5⁶	thioredoxin domain containing 5 (endoplasmic retic...	66(a)	1 ↔ 1	GL343209.1(882795-911967)
African clawed frog (Xenopus laevis)	Amphibia	BC045245.1²	--	76.01(n)		BC045245.1
zebrafish (Danio rerio)	Actinopterygii	Dr.25420²	Danio rerio cDNA clone MGC66265 IMAGE5410287, complete more	76.05(n)		BC057499.1
fruit fly (Drosophila melanogaster)	Insecta	prtp¹	pretaporter	54.83(n) 47.16(a)		32124 NM_132514.3 NP_572742.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	EPS1(YIL005W)⁴	ER protein with chaperone and co-chaperone activity, more	--		9(345692-347797) 854812 NP_012261.1

ENSEMBL Gene Tree for TXNDC5 (if available)
TreeFam Gene Tree for TXNDC5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TXNDC5 gene

DNAJC10² PDIA6² PDIA5²

4 SIMAP similar genes for TXNDC5 using alignment to 2 protein entries: TXND5_HUMAN (see all proteins):

DKFZp666I134 STRF8 PDIA6 TXN

TXNDC5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
Database of Genomic Variants (DGV) 3 variations for TXNDC5: About this table

Variant ID	Type	Subtype	PubMed ID
esv2731544	CNV	Deletion	23290073
nsv462625	CNV	Loss	19166990
nsv830582	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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11 diseases for TXNDC5:
About MalaCards

hypoxia vitiligo endotheliitis insulin resistance

schizophrenia adenoma hepatocellular carcinoma rheumatoid arthritis

arthritis malaria hepatitis

TXNDC5 for disorders About GeneDecksing

1 Novoseek inferred disease relationship for TXNDC5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	3	12963716 (2), 14607843 (1)

Genetic Association Database (GAD): TXNDC5
Human Genome Epidemiology (HuGE) Navigator: TXNDC5 (6 documents)

Export disorders for TXNDC5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TXNDC5 gene, integrated from 10 sources (see all 56):
(articles sorted by number of sources associating them with TXNDC5)

Utopia: connect your pdf to the dynamic
world of online information

Association of TXNDC5 gene polymorphisms and susceptibility to nonsegmental vitiligo in the Korean population. (PubMed id 19906073)^{1, 4, 9} Jeong K.H....Lee M.H. (Br. J. Dermatol. 2010)
Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)^{1, 4} So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)^{1, 4} Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
Clustering by neurocognition for fine mapping of the schizophrenia susceptibility loci on chromosome 6p. (PubMed id 19694819)^{1, 4} Lin S.H....Chen W.J. (Genes Brain Behav. 2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (Nature 2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (Genome Res. 2003)
EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor. (PubMed id 12963716)^{1, 9} Sullivan D.C....Bicknell R. (J. Biol. Chem. 2003)
Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins. (PubMed id 19887585)^{1, 9} Jessop C.E....Bulleid N.J. (J. Cell. Sci. 2009)

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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 81567	HGNC: 21073	AceView: EEF1E1	Ensembl:ENSG00000239264	euGenes: HUgn81567
ECgene: TXNDC5	Kegg: 81567	H-InvDB: TXNDC5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TXNDC5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TXNDC5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TXNDC5 gene:
Search GeneIP for patents involving TXNDC5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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TXNDC5 Gene

Thioredoxin Domain Containing 5 (Endoplasmic Reticulum)

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TXNDC5 (Gene Symbol)
Thioredoxin Domain Containing 5 (Endoplasmic Reticulum)
Endoplasmic Reticulum Resident Protein 46
Thioredoxin-Like Protein P46
ER Protein 46
Member 15
Protein Disulfide Isomerase Family A
Thioredoxin Domain Containing 5
ENDOPDI
ERP46
HCC-2
PDIA15
STRF8
UNQ364
Endoplasmic Reticulum Protein ERp46
Endothelial Protein Disulphide Isomerase
Protein Disulfide Isomerase Family A, Member 15
Thioredoxin Domain-Containing Protein 5
Thioredoxin Related Protein
ERp46
TLP46

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TXNDC5 Gene

Thioredoxin Domain Containing 5 (Endoplasmic Reticulum)

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for TXNDC5 gene

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for TXNDC5 gene

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for TXNDC5 gene

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for TXNDC5 gene

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