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Aliases for TXNDC5 Gene

Aliases for TXNDC5 Gene

  • Thioredoxin Domain Containing 5 2 3
  • Thioredoxin Domain Containing 5 (Endoplasmic Reticulum) 2 3 5
  • Endoplasmic Reticulum Resident Protein 46 3 4
  • Thioredoxin-Like Protein P46 3 4
  • ER Protein 46 3 4
  • ERP46 3 4
  • Protein Disulfide Isomerase Family A, Member 15 3
  • Endothelial Protein Disulphide Isomerase 3
  • Protein Disulfide Isomerase Family A 2
  • Endoplasmic Reticulum Protein ERp46 3
  • Thioredoxin Related Protein 3
  • Member 15 2
  • PDIA15 3
  • UNQ364 3
  • HCC-2 3
  • STRF8 3
  • TLP46 4
  • HCC2 3

External Ids for TXNDC5 Gene

Previous GeneCards Identifiers for TXNDC5 Gene

  • GC06M007871
  • GC06M007826

Summaries for TXNDC5 Gene

Entrez Gene Summary for TXNDC5 Gene

  • This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for TXNDC5 Gene

TXNDC5 (Thioredoxin Domain Containing 5) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Vesicle-mediated transport. GO annotations related to this gene include isomerase activity and protein disulfide isomerase activity. An important paralog of this gene is PDIA6.

UniProtKB/Swiss-Prot for TXNDC5 Gene

  • Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).

Gene Wiki entry for TXNDC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC5 Gene

Genomics for TXNDC5 Gene

Regulatory Elements for TXNDC5 Gene

Enhancers for TXNDC5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TXNDC5 on UCSC Golden Path with GeneCards custom track

Promoters for TXNDC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TXNDC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TXNDC5 Gene

7,881,250 bp from pter
7,910,814 bp from pter
29,565 bases
Minus strand

Genomic View for TXNDC5 Gene

Genes around TXNDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC5 Gene

Proteins for TXNDC5 Gene

  • Protein details for TXNDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • B2RDM2
    • Q5TCQ0
    • Q8ND33
    • Q8TCT2
    • Q9BVH9

    Protein attributes for TXNDC5 Gene

    432 amino acids
    Molecular mass:
    47629 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH01199.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TXNDC5 Gene

    Alternative splice isoforms for TXNDC5 Gene


neXtProt entry for TXNDC5 Gene

Proteomics data for TXNDC5 Gene at MOPED

Post-translational modifications for TXNDC5 Gene

  • Ubiquitination at Lys 113 and Lys 150
  • Glycosylation at Thr 72
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNDC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TXNDC5 Gene

Domains & Families for TXNDC5 Gene

Gene Families for TXNDC5 Gene

Suggested Antigen Peptide Sequences for TXNDC5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 thioredoxin domains.
  • Belongs to the protein disulfide isomerase family.
  • Contains 3 thioredoxin domains.
  • Belongs to the protein disulfide isomerase family.
genes like me logo Genes that share domains with TXNDC5: view

Function for TXNDC5 Gene

Molecular function for TXNDC5 Gene

UniProtKB/Swiss-Prot Function:
Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).
genes like me logo Genes that share phenotypes with TXNDC5: view

Animal Models for TXNDC5 Gene

MGI Knock Outs for TXNDC5:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TXNDC5 Gene

Localization for TXNDC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC5 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Jensen Localization Image for TXNDC5 Gene COMPARTMENTS Subcellular localization image for TXNDC5 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
lysosome 5
vacuole 5
cytosol 3
golgi apparatus 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TXNDC5 Gene

Pathways & Interactions for TXNDC5 Gene

genes like me logo Genes that share pathways with TXNDC5: view

Gene Ontology (GO) - Biological Process for TXNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0034976 response to endoplasmic reticulum stress IBA --
GO:0043066 negative regulation of apoptotic process TAS 16130169
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with TXNDC5: view

No data available for SIGNOR curated interactions for TXNDC5 Gene

Drugs & Compounds for TXNDC5 Gene

No Compound Related Data Available

Transcripts for TXNDC5 Gene

Unigene Clusters for TXNDC5 Gene

Thioredoxin domain containing 5 (endoplasmic reticulum):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC5 Gene

No ASD Table

Relevant External Links for TXNDC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC5 Gene

mRNA expression in normal human tissues for TXNDC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TXNDC5 Gene

This gene is overexpressed in Oral epithelium (11.3) and Tonsil (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXNDC5 Gene

SOURCE GeneReport for Unigene cluster for TXNDC5 Gene Hs.150837

genes like me logo Genes that share expression patterns with TXNDC5: view

Protein tissue co-expression partners for TXNDC5 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TXNDC5 Gene

Orthologs for TXNDC5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TXNDC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TXNDC5 35
  • 85.42 (n)
  • 89.33 (a)
  • 88 (a)
(Canis familiaris)
Mammalia TXNDC5 35
  • 85.91 (n)
  • 87.76 (a)
  • 89 (a)
(Mus musculus)
Mammalia Txndc5 35
  • 86.81 (n)
  • 89.57 (a)
Txndc5 16
Txndc5 36
  • 87 (a)
(Pan troglodytes)
Mammalia TXNDC5 35
  • 99.44 (n)
  • 98.98 (a)
  • 95 (a)
(Rattus norvegicus)
Mammalia Txndc5 35
  • 85.83 (n)
  • 89.84 (a)
(Monodelphis domestica)
Mammalia TXNDC5 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia TXNDC5 36
  • 69 (a)
(Gallus gallus)
Aves TXNDC5 35
  • 74.53 (n)
  • 74.53 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia TXNDC5 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75894 35
txndc5 35
  • 67.91 (n)
  • 67.2 (a)
(Danio rerio)
Actinopterygii Dr.25420 35
txndc5 35
  • 66.25 (n)
  • 65.94 (a)
txndc5 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000044 35
  • 53.96 (n)
  • 43.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta prtp 35
  • 54.83 (n)
  • 47.16 (a)
prtp 36
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPD1 36
  • 19 (a)
EPS1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2468 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for TXNDC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC5 Gene

Gene Tree for TXNDC5 (if available)
Gene Tree for TXNDC5 (if available)

Paralogs for TXNDC5 Gene

Paralogs for TXNDC5 Gene

(4) SIMAP similar genes for TXNDC5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TXNDC5: view

Variants for TXNDC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for TXNDC5 Gene

Variant ID Type Subtype PubMed ID
nsv830582 CNV Loss 17160897
esv2731544 CNV Deletion 23290073
nsv462625 CNV Loss 19166990

Variation tolerance for TXNDC5 Gene

Residual Variation Intolerance Score: 71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for TXNDC5 Gene

Disorders for TXNDC5 Gene

Relevant External Links for TXNDC5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TXNDC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC5 Gene

Publications for TXNDC5 Gene

  1. Association of TXNDC5 gene polymorphisms and susceptibility to nonsegmental vitiligo in the Korean population. (PMID: 19906073) Jeong K.H. … Lee M.H. (Br. J. Dermatol. 2010) 3 23 48 67
  2. Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins. (PMID: 19887585) Jessop C.E. … Bulleid N.J. (J. Cell. Sci. 2009) 3 23
  3. Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study. (PMID: 17895523) Wang Y. … Lai M. (Exp. Biol. Med. (Maywood) 2007) 3 23
  4. EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor. (PMID: 12963716) Sullivan D.C. … Bicknell R. (J. Biol. Chem. 2003) 3 23
  5. The role of TXNDC5 in castration-resistant prostate cancer-involvement of androgen receptor signaling pathway. (PMID: 25500540) Wang L. … Han B. (Oncogene 2015) 3

Products for TXNDC5 Gene

Sources for TXNDC5 Gene