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Aliases for TXNDC5 Gene

Aliases for TXNDC5 Gene

  • Thioredoxin Domain Containing 5 2 3 5
  • Thioredoxin Domain Containing 5 (Endoplasmic Reticulum) 2 3
  • Protein Disulfide Isomerase Family A, Member 15 2 3
  • Endoplasmic Reticulum Resident Protein 46 3 4
  • Thioredoxin-Like Protein P46 3 4
  • ER Protein 46 3 4
  • ERP46 3 4
  • Endothelial Protein Disulphide Isomerase 3
  • Thioredoxin Domain-Containing Protein 5 3
  • Endoplasmic Reticulum Protein ERp46 3
  • Thioredoxin Related Protein 3
  • ENDOPDI 3
  • PDIA15 3
  • UNQ364 3
  • HCC-2 3
  • STRF8 3
  • TLP46 4
  • HCC2 3

External Ids for TXNDC5 Gene

Previous GeneCards Identifiers for TXNDC5 Gene

  • GC06M007871
  • GC06M007826

Summaries for TXNDC5 Gene

Entrez Gene Summary for TXNDC5 Gene

  • This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for TXNDC5 Gene

TXNDC5 (Thioredoxin Domain Containing 5) is a Protein Coding gene. Among its related pathways are Immune System and Vesicle-mediated transport. GO annotations related to this gene include isomerase activity and protein disulfide isomerase activity. An important paralog of this gene is DNAJC10.

UniProtKB/Swiss-Prot for TXNDC5 Gene

  • Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).

Gene Wiki entry for TXNDC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC5 Gene

Genomics for TXNDC5 Gene

Regulatory Elements for TXNDC5 Gene

Enhancers for TXNDC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F007882 0.7 ENCODE 17.2 +28.0 27969 1.0 ELF3 ZSCAN9 GATAD1 NR2F6 HOMEZ MAFK THAP11 GATAD2A SOX5 FOXA3 TXNDC5 BMP6 BLOC1S5 PIR41509 GC06P007902
GH06F007908 0.2 ENCODE 16.8 +0.5 467 3.3 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 TXNDC5 BMP6 BLOC1S5 LOC100506207 GC06P007902
GH06F007899 0.5 ENCODE 15.4 +11.1 11101 1.0 PKNOX1 ATF1 ARNT CREB3L1 YY1 ZNF766 ELK1 GATA2 JUNB NCOA1 TXNDC5 BLOC1S5 GC06P007902 PIR41509
GH06F008063 1.1 ENCODE 12.9 -153.9 -153867 2.8 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 LOC100422646 RIOK1 TXNDC5 BLOC1S5 BLOC1S5-TXNDC5 SCARNA27
GH06F007999 0.6 ENCODE 12.4 -89.6 -89596 1.9 ARID1B PKNOX1 TAL1 JUN MAX REST BLOC1S5 TXNDC5 BMP6 ENSG00000238221 PIR57650 GC06P007990 PIR38170
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TXNDC5 on UCSC Golden Path with GeneCards custom track

Promoters for TXNDC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001210419 714 2601 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for TXNDC5 Gene

Chromosome:
6
Start:
7,881,250 bp from pter
End:
7,910,814 bp from pter
Size:
29,565 bases
Orientation:
Minus strand

Genomic View for TXNDC5 Gene

Genes around TXNDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC5 Gene

Proteins for TXNDC5 Gene

  • Protein details for TXNDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBS9-TXND5_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 5
    Protein Accession:
    Q8NBS9
    Secondary Accessions:
    • B2RDM2
    • Q5TCQ0
    • Q8ND33
    • Q8TCT2
    • Q9BVH9

    Protein attributes for TXNDC5 Gene

    Size:
    432 amino acids
    Molecular mass:
    47629 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH01199.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TXNDC5 Gene

    Alternative splice isoforms for TXNDC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TXNDC5 Gene

Post-translational modifications for TXNDC5 Gene

  • Ubiquitination at Lys 113 and Lys 150
  • Glycosylation at Thr 72
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNDC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TXNDC5 Gene

Domains & Families for TXNDC5 Gene

Gene Families for TXNDC5 Gene

Suggested Antigen Peptide Sequences for TXNDC5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NBS9

UniProtKB/Swiss-Prot:

TXND5_HUMAN :
  • Contains 3 thioredoxin domains.
  • Belongs to the protein disulfide isomerase family.
Domain:
  • Contains 3 thioredoxin domains.
Family:
  • Belongs to the protein disulfide isomerase family.
genes like me logo Genes that share domains with TXNDC5: view

Function for TXNDC5 Gene

Molecular function for TXNDC5 Gene

UniProtKB/Swiss-Prot Function:
Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).

Gene Ontology (GO) - Molecular Function for TXNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IBA --
GO:0005515 protein binding IPI 21057456
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with TXNDC5: view
genes like me logo Genes that share phenotypes with TXNDC5: view

Animal Models for TXNDC5 Gene

MGI Knock Outs for TXNDC5:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TXNDC5 Gene

Localization for TXNDC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC5 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXNDC5 Gene COMPARTMENTS Subcellular localization image for TXNDC5 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
lysosome 5
vacuole 5
cytosol 3
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TXNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005783 endoplasmic reticulum TAS 16130169
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0043202 lysosomal lumen TAS --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with TXNDC5: view

Pathways & Interactions for TXNDC5 Gene

genes like me logo Genes that share pathways with TXNDC5: view

Gene Ontology (GO) - Biological Process for TXNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0034976 response to endoplasmic reticulum stress IBA --
GO:0043066 negative regulation of apoptotic process TAS 16130169
GO:0043277 apoptotic cell clearance IBA --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TXNDC5: view

No data available for SIGNOR curated interactions for TXNDC5 Gene

Transcripts for TXNDC5 Gene

Unigene Clusters for TXNDC5 Gene

Thioredoxin domain containing 5 (endoplasmic reticulum):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC5 Gene

No ASD Table

Relevant External Links for TXNDC5 Gene

GeneLoc Exon Structure for
TXNDC5
ECgene alternative splicing isoforms for
TXNDC5

Expression for TXNDC5 Gene

mRNA expression in normal human tissues for TXNDC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TXNDC5 Gene

This gene is overexpressed in Oral epithelium (11.3) and Tonsil (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXNDC5 Gene



Protein tissue co-expression partners for TXNDC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TXNDC5 Gene:

TXNDC5

SOURCE GeneReport for Unigene cluster for TXNDC5 Gene:

Hs.150837
genes like me logo Genes that share expression patterns with TXNDC5: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TXNDC5 Gene

Orthologs for TXNDC5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TXNDC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNDC5 34 35
  • 99.44 (n)
mouse
(Mus musculus)
Mammalia Txndc5 34 16 35
  • 86.81 (n)
dog
(Canis familiaris)
Mammalia TXNDC5 34 35
  • 85.91 (n)
rat
(Rattus norvegicus)
Mammalia Txndc5 34
  • 85.83 (n)
cow
(Bos Taurus)
Mammalia TXNDC5 34 35
  • 85.42 (n)
oppossum
(Monodelphis domestica)
Mammalia TXNDC5 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TXNDC5 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TXNDC5 34 35
  • 74.53 (n)
lizard
(Anolis carolinensis)
Reptilia TXNDC5 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc5 34
  • 67.91 (n)
MGC75894 34
zebrafish
(Danio rerio)
Actinopterygii txndc5 34 35
  • 66.25 (n)
Dr.25420 34
fruit fly
(Drosophila melanogaster)
Insecta prtp 34 35
  • 54.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000044 34
  • 53.96 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPD1 35
  • 19 (a)
OneToMany
EPS1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2468 34
Species where no ortholog for TXNDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC5 Gene

ENSEMBL:
Gene Tree for TXNDC5 (if available)
TreeFam:
Gene Tree for TXNDC5 (if available)

Paralogs for TXNDC5 Gene

Paralogs for TXNDC5 Gene

(4) SIMAP similar genes for TXNDC5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TXNDC5: view

Variants for TXNDC5 Gene

Sequence variations from dbSNP and Humsavar for TXNDC5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1004396 -- 7,890,089(-) GACAT(C/T)TTTGC intron-variant
rs1043784 -- 7,881,698(-) CACGT(A/G)TGGTT nc-transcript-variant, utr-variant-3-prime
rs1044104 -- 7,881,078(-) GAGCA(C/T)TGCCT downstream-variant-500B, utr-variant-3-prime
rs1062680 -- 7,882,265(-) TGACA(A/G)GACCA nc-transcript-variant, utr-variant-3-prime
rs10708121 -- 7,908,519(+) TCTTT(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC5 Gene

Variant ID Type Subtype PubMed ID
esv2731544 CNV deletion 23290073
esv3890787 CNV loss 25118596
nsv1133014 OTHER inversion 24896259
nsv1145091 CNV deletion 24896259
nsv1151332 OTHER inversion 26484159
nsv462625 CNV loss 19166990
nsv600924 CNV gain 21841781
nsv600925 CNV loss 21841781
nsv830582 CNV loss 17160897

Variation tolerance for TXNDC5 Gene

Residual Variation Intolerance Score: 71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNDC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNDC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC5 Gene

Disorders for TXNDC5 Gene

Relevant External Links for TXNDC5

Genetic Association Database (GAD)
TXNDC5
Human Genome Epidemiology (HuGE) Navigator
TXNDC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXNDC5

No disorders were found for TXNDC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC5 Gene

Publications for TXNDC5 Gene

  1. Association of TXNDC5 gene polymorphisms and susceptibility to nonsegmental vitiligo in the Korean population. (PMID: 19906073) Jeong K.H. … Lee M.H. (Br. J. Dermatol. 2010) 3 22 46 64
  2. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So H.C. … Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 46 64
  4. Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins. (PMID: 19887585) Jessop C.E. … Bulleid N.J. (J. Cell. Sci. 2009) 3 22 64
  5. Clustering by neurocognition for fine mapping of the schizophrenia susceptibility loci on chromosome 6p. (PMID: 19694819) Lin S.H. … Chen W.J. (Genes Brain Behav. 2009) 3 46 64

Products for TXNDC5 Gene

Sources for TXNDC5 Gene

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