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Aliases for TXNDC2 Gene

Aliases for TXNDC2 Gene

  • Thioredoxin Domain Containing 2 (Spermatozoa) 2 3
  • Spermatid-Specific Thioredoxin-1 3 4
  • Sperm-Specific Thioredoxin 1 2 3
  • Sptrx-1 3 4
  • SPTRX1 3 4
  • SPTRX 3 4
  • Thioredoxin Domain-Containing 2 (Spermatozoa) 3
  • Thioredoxin Domain-Containing Protein 2 3

External Ids for TXNDC2 Gene

Previous GeneCards Identifiers for TXNDC2 Gene

  • GC18P010019

Summaries for TXNDC2 Gene

GeneCards Summary for TXNDC2 Gene

TXNDC2 (Thioredoxin Domain Containing 2 (Spermatozoa)) is a Protein Coding gene. Diseases associated with TXNDC2 include malignant pleural mesothelioma. GO annotations related to this gene include electron carrier activity and protein disulfide isomerase activity. An important paralog of this gene is TXN.

UniProtKB/Swiss-Prot for TXNDC2 Gene

  • Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase

Gene Wiki entry for TXNDC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC2 Gene

Genomics for TXNDC2 Gene

Regulatory Elements for TXNDC2 Gene

Genomic Location for TXNDC2 Gene

Start:
9,885,726 bp from pter
End:
9,889,275 bp from pter
Size:
3,550 bases
Orientation:
Plus strand

Genomic View for TXNDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXNDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC2 Gene

Proteins for TXNDC2 Gene

  • Protein details for TXNDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VQ3-TXND2_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 2
    Protein Accession:
    Q86VQ3
    Secondary Accessions:
    • A5YM73
    • Q8N7U4
    • Q96RX3
    • Q9H0L8

    Protein attributes for TXNDC2 Gene

    Size:
    553 amino acids
    Molecular mass:
    60404 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TXNDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TXNDC2 Gene

Proteomics data for TXNDC2 Gene at MOPED

Post-translational modifications for TXNDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TXNDC2 Gene

No data available for DME Specific Peptides for TXNDC2 Gene

Domains for TXNDC2 Gene

Protein Domains for TXNDC2 Gene

Suggested Antigen Peptide Sequences for TXNDC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VQ3

UniProtKB/Swiss-Prot:

TXND2_HUMAN :
  • Q86VQ3
Domain:
  • Contains 1 thioredoxin domain.
genes like me logo Genes that share domains with TXNDC2: view

No data available for Gene Families for TXNDC2 Gene

Function for TXNDC2 Gene

Molecular function for TXNDC2 Gene

UniProtKB/Swiss-Prot Function: Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase

Gene Ontology (GO) - Molecular Function for TXNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IEA --
GO:0004791 thioredoxin-disulfide reductase activity ISS --
GO:0015035 protein disulfide oxidoreductase activity IBA --
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA --
GO:0045735 nutrient reservoir activity IEA --
genes like me logo Genes that share ontologies with TXNDC2: view
genes like me logo Genes that share phenotypes with TXNDC2: view

Animal Models for TXNDC2 Gene

MGI Knock Outs for TXNDC2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXNDC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TXNDC2 Gene

Localization for TXNDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC2 Gene

Cytoplasm. Note=In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXNDC2 Gene COMPARTMENTS Subcellular localization image for TXNDC2 gene
Compartment Confidence
cytosol 4
nucleus 4
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TXNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001520 outer dense fiber IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TXNDC2: view

Pathways for TXNDC2 Gene

SuperPathways for TXNDC2 Gene

No Data Available

Interacting Proteins for TXNDC2 Gene

Gene Ontology (GO) - Biological Process for TXNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000103 sulfate assimilation IBA --
GO:0006457 protein folding IBA --
GO:0006662 glycerol ether metabolic process IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis NAS 11399755
genes like me logo Genes that share ontologies with TXNDC2: view

No data available for Pathways by source for TXNDC2 Gene

Compounds for TXNDC2 Gene

(1) HMDB Compounds for TXNDC2 Gene

Compound Synonyms Cas Number PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8

(1) Novoseek inferred chemical compound relationships for TXNDC2 Gene

Compound -log(P) Hits PubMed IDs
nadph 47.1 2
genes like me logo Genes that share compounds with TXNDC2: view

Transcripts for TXNDC2 Gene

Unigene Clusters for TXNDC2 Gene

Thioredoxin domain containing 2 (spermatozoa):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXNDC2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TXNDC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for TXNDC2 Gene

GeneLoc Exon Structure for
TXNDC2
ECgene alternative splicing isoforms for
TXNDC2

Expression for TXNDC2 Gene

mRNA expression in normal human tissues for TXNDC2 Gene

mRNA differential expression in normal tissues according to GTEx for TXNDC2 Gene

This gene is overexpressed in Testis (50.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TXNDC2 Gene

SOURCE GeneReport for Unigene cluster for TXNDC2 Gene Hs.98712

mRNA Expression by UniProt/SwissProt for TXNDC2 Gene

Q86VQ3-TXND2_HUMAN
Tissue specificity: Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids.
genes like me logo Genes that share expressions with TXNDC2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TXNDC2 Gene

Orthologs for TXNDC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TXNDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNDC2 35
  • 97.63 (n)
  • 95.53 (a)
TXNDC2 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TXNDC2 35
  • 69.39 (n)
  • 48.6 (a)
TXNDC2 36
  • 40 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TXNDC2 35
  • 71.2 (n)
  • 53.33 (a)
TXNDC2 36
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Txndc2 35
  • 68.17 (n)
  • 47.47 (a)
Txndc2 16
Txndc2 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Txndc2 35
  • 69.38 (n)
  • 47.92 (a)
chicken
(Gallus gallus)
Aves TXN 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10782 35
zebrafish
(Danio rerio)
Actinopterygii txn 36
  • 50 (a)
ManyToMany
zgc:56493 36
  • 44 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Trx-2 36
  • 42 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trx-1 36
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRX1 36
  • 28 (a)
ManyToMany
TRX2 36
  • 32 (a)
ManyToMany
TRX3 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11205 36
  • 38 (a)
ManyToMany
Species with no ortholog for TXNDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TXNDC2 Gene

ENSEMBL:
Gene Tree for TXNDC2 (if available)
TreeFam:
Gene Tree for TXNDC2 (if available)

Paralogs for TXNDC2 Gene

Paralogs for TXNDC2 Gene

genes like me logo Genes that share paralogs with TXNDC2: view

Variants for TXNDC2 Gene

Sequence variations from dbSNP and Humsavar for TXNDC2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs492090 -- 9,889,171(-) TGTGC(A/T)GTTCT utr-variant-3-prime
rs534849 -- 9,885,319(-) TACAT(A/G)TACTT upstream-variant-2KB
rs550585 -- 9,888,771(-) TCCGA(C/T)CTCTT utr-variant-3-prime
rs551429 -- 9,888,691(-) TCTCA(C/T)TTCCG utr-variant-3-prime
rs584815 -- 9,885,445(+) CAGGT(A/G)TTTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TXNDC2 Gene

Variant ID Type Subtype PubMed ID
nsv833586 CNV Loss 17160897
nsv527829 CNV Gain 19592680
esv2716777 CNV Deletion 23290073
esv2716778 CNV Deletion 23290073

Relevant External Links for TXNDC2 Gene

HapMap Linkage Disequilibrium report
TXNDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC2 Gene

Disorders for TXNDC2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TXNDC2 Gene including...

Search for TXNDC2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TXNDC2 Gene

Relevant External Links for TXNDC2

Genetic Association Database (GAD)
TXNDC2
genes like me logo Genes that share disorders with TXNDC2: view

No data available for UniProtKB/Swiss-Prot for TXNDC2 Gene

Publications for TXNDC2 Gene

  1. Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa. (PMID: 11399755) Miranda-Vizuete A. … Spyrou G. (J. Biol. Chem. 2001) 2 3 4 23
  2. Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity. (PMID: 12387870) Jimenez A. … Miranda-Vizuete A. (FEBS Lett. 2002) 3 4 23
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TXNDC2 Gene

Sources for TXNDC2 Gene

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