Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TXNDC2 Gene

protein-coding   GIFtS: 49
GCID: GC18P009875

thioredoxin domain containing 2 (spermatozoa)

 Explore 6 diseases affiliated with
TXNDC2 via our new
 Human Malady Compendium 
Biological research products
for TXNDC2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Thioredoxin Domain Containing 2 (Spermatozoa)1 2     Sptrx-13
SPTRX11 2 3     Thioredoxin Domain-Containing 2 (Spermatozoa)2
Spermatid-Specific Thioredoxin-12 3     Thioredoxin Domain-Containing Protein 22
SPTRX2 3     Sptrx-13
Sperm-Specific Thioredoxin 12     

External Ids:    HGNC: 164701   Entrez Gene: 842032   Ensembl: ENSG000001684547   UniProtKB: Q86VQ33   

Export aliases for TXNDC2 gene to outside databases

Previous GC identifer: GC18P010019


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TXND2_HUMAN, Q86VQ3
Function: Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS)
assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to
rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide
bonds in vitro in the presence of NADP and thioredoxin reductase

Gene Wiki entry for TXNDC2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010859.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TXNDC2 gene promoter:
         CBF-A   CBF-B   NF-YC   CP1A   CBF(2)   CBF-C   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXNDC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TXNDC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  18p11.22   HGNC cytogenetic band: 18p11.31-p11.2

TXNDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNDC2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P009875:  view genomic region     (about GC identifiers)

Start:
9,885,723 bp from pter      End:
9,889,272 bp from pter
Size:
3,550 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TXND2_HUMAN, Q86VQ3 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 2  
Size: 553 amino acids; 60404 Da
Subcellular location: Cytoplasm. Note=In ejaculated spermatozoa, it localizes in the caudal region of the head to the
end of the principal piece
Secondary accessions: Q8N7U4 Q96RX3 Q9H0L8
Alternative splicing: 2 isoforms:  Q86VQ3-1   Q86VQ3-2   

Explore the universe of human proteins at neXtProt for TXNDC2: NX_Q86VQ3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86VQ3

  • TXNDC2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091999.1  NP_115619.4  

    ENSEMBL proteins: 
     ENSP00000437393   ENSP00000464677   ENSP00000350419   ENSP00000304908   ENSP00000400846  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for TXNDC2 
    GenScript Custom Purified and Recombinant Proteins Services for TXNDC2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TXNDC2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001520outer dense fiber IEA--
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm ISS--


    TXNDC2 for ontologies           About GeneDecksing



    TXNDC2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TXNDC2 
    GenScript Custom Superior Antibodies Services for TXNDC2
    Novus Biologicals TXNDC2 Antibody
    Search for Antibodies for TXNDC2 at Abcam  
    Uscn Antibodies for TXNDC2
    Search ThermoFisher Antibodies for TXNDC2

    Assay Products for TXNDC2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TXNDC2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TXNDC2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TXNDC2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013766 Thioredoxin_domain
     IPR001419 Glutenin
     IPR005746 Thioredoxin
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q86VQ3

    ProtoNet protein and cluster: Q86VQ3

    1 Blocks protein family: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TXND2_HUMAN, Q86VQ3
    Similarity: Contains 1 thioredoxin domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TXND2_HUMAN, Q86VQ3
    Function: Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS)
    assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to
    rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide
    bonds in vitro in the presence of NADP and thioredoxin reductase

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNDC2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TXNDC2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TXNDC2 (see all 7)
    OriGene shRNA RFP: TXNDC2
    OriGene siRNA: TXNDC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNDC2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TXNDC2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC2 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TXNDC2 (NM_032243)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNDC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TXNDC2
    Search LifeMap BioReagents cell lines for TXNDC2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004791thioredoxin-disulfide reductase activity ISS--
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0045735nutrient reservoir activity IEA--


    TXNDC2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TXNDC2:
     Big cells 

    Animal Models:
         Mouse knock-out Txndc2tm1Lex for TXNDC2
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Txndc2):
     growth/size  homeostasis/metabolism  immune system 

    TXNDC2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TXNDC2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TXNDC2 (Q86VQ33 ENSP000003049084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006662glycerol ether metabolic process IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis NAS11399755
    GO:0030154cell differentiation IEA--
    GO:0045454cell redox homeostasis NAS11399755


    TXNDC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TXNDC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TXNDC2

    1 HMDB Compound for TXNDC2    About this table
    CompoundSynonyms CAS #PubMed Ids
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    1 Novoseek chemical compound relationship for TXNDC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadph 47.1 2 11399755 (1), 12149401 (1)

    Search CenterWatch for drugs/clinical trials and news about TXNDC2 / TXND2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TXNDC2 gene (2 alternative transcripts): 
    NM_001098529.1  NM_032243.5  

    Unigene Cluster for TXNDC2:

    Thioredoxin domain containing 2 (spermatozoa)
    Hs.98712  [show with all ESTs]
    Unigene Representative Sequence: NM_001098529
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536353 ENST00000584255 ENST00000357775(uc002koh.4) ENST00000306084(uc002koi.4)
    ENST00000426718 ENST00000577697(uc021ugx.1)

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNDC2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TXNDC2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TXNDC2 (see all 7)
    OriGene shRNA RFP: TXNDC2
    OriGene siRNA: TXNDC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNDC2
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC2 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TXNDC2 (NM_032243)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNDC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXNDC2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXNDC2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC2

    Additional cDNA sequence: 

    AF080095.1 AK097656.1 AK303045.1 BC050132.1 EF560747.1 

    3 DOTS entries:

    DT.75107258  DT.100017816  DT.121083918 

    21 AceView cDNA sequences:

    AF080095 NM_032243 BI829219 BM554364 AI125222 AL136742 BC050132 BI831969 
    CD557557 AK097656 BI463874 BI826592 BM559733 BI828938 BM553904 BI832369 
    BI828141 BI831948 BI831646 BI562175 BI460141 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c
    SP1:              -                 -     -                     
    SP2:                                -     -                     
    SP3:                                      -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for TXNDC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TXNDC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTCTGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TXNDC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TXNDC2

    SOURCE GeneReport for Unigene cluster: Hs.98712

    UniProtKB/Swiss-Prot: TXND2_HUMAN, Q86VQ3
    Tissue specificity: Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating
    spermatids

        SABiosciences Custom PCR Arrays for TXNDC2
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXNDC2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXNDC2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TXNDC2 gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves THIO_CHICK6
    Thioredoxin
    58(a)
    1 → many
    Z(65067372-65073552)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    52(a)
    1 → many
    GL343476.1(264630-273279)
    zebrafish
    (Danio rerio)
    Actinopterygii txn6
    zgc:564936
    zgc:56493
    50(a)
    44(a)
    many ↔ many
    many ↔ many
    7(25524322-25531917)
    1(40656189-40663079)
    fruit fly
    (Drosophila melanogaster)
    Insecta Trx-26
    TrxT6
    (see all 3)
    Thioredoxin T
    (see all 3)
    42(a)
    22(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    2L(9613165-9616048)
    X(5204614-5205921)
    worm
    (Caenorhabditis elegans)
    Secernentea trx-16
    Thioredoxin-1
    30(a)
    possible ortholog
    II(7752579-7753554)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATY16
    Aty26
    (see all 3)
    thioredoxin Y2
    (see all 3)
    19(a)
    18(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    1(28811685-28813070)
    1(16398099-16399878)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    thioredoxin, putative, expressed
    20(a)
    14(a)
    possible ortholog
    possible ortholog
    1(42450072-42453265)
    8(17815710-17817807)


    ENSEMBL Gene Tree for TXNDC2 (if available)
    TreeFam Gene Tree for TXNDC2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TXNDC2 gene
    TXNDC82  TXN2  TXNL12  
    2 SIMAP similar genes for TXNDC2 using alignment to 5 protein entries:     TXND2_HUMAN (see all proteins):
    TXN    TXNDC8

    TXNDC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/169 NCBI SNPs in TXNDC2 are shown (see all 169    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880822371,2
    --9883729(+) TCTTGA/CTCTGT 2 -- us2k10--------
    rs1909391611,2
    --9883773(+) CTCACG/TGCAAC 2 -- us2k10--------
    rs1389167411,2
    --9883816(+) CTCAGA/CCTCCT 2 -- us2k10--------
    rs99464201,2
    C,--9883864(+) GCTAAC/GTTTCG 2 -- us2k13Minor allele frequency- G:0.14WA EA 240
    rs1827663481,2
    --9883884(+) TAGAGA/TTCTAA 2 -- us2k10--------
    rs1888856031,2
    --9883894(+) AAATCA/GCATTT 2 -- us2k10--------
    rs1424470421,2
    --9883933(+) CTGTGC/TTGGCA 2 -- us2k10--------
    rs1925905281,2
    --9883987(+) TTGCCC/TCCACA 2 -- us2k10--------
    rs1845650761,2
    --9884162(+) TTGTGC/TTAATA 2 -- us2k10--------
    rs1398031131,2
    --9884170(+) ATAAAA/GTCTGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TXNDC2 (9885723 - 9889272 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TXNDC2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TXNDC2
    DNA2.0 Custom Variant and Variant Library Synthesis for TXNDC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TXNDC2 for disorders           About GeneDecksing

    6 diseases for TXNDC2:    About MalaCards
    primary ciliary dyskinesia    ciliary dyskinesia    pneumonia    tuberculosis
    malaria    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for TXNDC2:
    Primary ciliary dyskinesia

    Export disorders for TXNDC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TXNDC2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with TXNDC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa. (PubMed id 11399755)1, 2, 3, 9 Miranda-Vizuete A.... Spyrou G. (2001)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    3. Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity. (PubMed id 12387870)1, 2, 9 Jimenez A.... Miranda-Vizuete A. (2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Is serum thioredoxin-1 a useful clinical marker for m alignant pleural mesothelioma? (PubMed id 21375472)1 Maeda R....Nakano T. (2011)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84203 HGNC: 16470 AceView: TXNDC2 Ensembl:ENSG00000168454 euGenes: HUgn84203
    ECgene: TXNDC2 H-InvDB: TXNDC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TXNDC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TXNDC2 gene:
    Search GeneIP for patents involving TXNDC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TXNDC2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TXNDC2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXNDC2  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TXNDC2   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TXNDC2   OriGene Custom Protein Services for TXNDC2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TXNDC2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TXNDC2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNDC2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC2
     GenScript Custom Purified and Recombinant Proteins Services for TXNDC2 GenScript cDNA clones with any tag delivered in your preferred vector for TXNDC2
     GenScript Custom Assay Services for TXNDC2 GenScript Custom Superior Antibodies Services for TXNDC2
     GenScript Custom overexpressing Cell Line Services for TXNDC2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TXNDC2 promoter
     Search Chromatin IP Primers for TXNDC2
     RT2 qPCR Primer Assay in human, mouse, rat TXNDC2
     Search GNC Networks for TXNDC2
     SABiosciences Custom PCR Arrays for TXNDC2
     Search Tocris compounds for TXNDC2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TXNDC2 antibodies
     Search for Antibodies for TXNDC2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TXNDC2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TXNDC2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TXNDC2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TXNDC2
     SwitchGear Promoter luciferase reporter plasmids for TXNDC2
     Search ThermoFisher Antibodies for TXNDC2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TXNDC2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4