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Aliases for TXNDC2 Gene

Aliases for TXNDC2 Gene

  • Thioredoxin Domain Containing 2 2 3 5
  • Thioredoxin Domain Containing 2 (Spermatozoa) 2 3
  • Spermatid-Specific Thioredoxin-1 3 4
  • Sperm-Specific Thioredoxin 1 2 3
  • Sptrx-1 3 4
  • SPTRX1 3 4
  • SPTRX 3 4
  • Thioredoxin Domain-Containing Protein 2 3
  • Testicular Tissue Protein Li 215 3

External Ids for TXNDC2 Gene

Previous GeneCards Identifiers for TXNDC2 Gene

  • GC18P010019

Summaries for TXNDC2 Gene

GeneCards Summary for TXNDC2 Gene

TXNDC2 (Thioredoxin Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include protein disulfide oxidoreductase activity and oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor. An important paralog of this gene is TXN.

UniProtKB/Swiss-Prot for TXNDC2 Gene

  • Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

Gene Wiki entry for TXNDC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC2 Gene

Genomics for TXNDC2 Gene

Regulatory Elements for TXNDC2 Gene

Enhancers for TXNDC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G009823 2 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -59.3 -59293 6.7 HDGF PKNOX1 CREB3L1 ARNT SIN3A YBX1 ZNF766 ZNF207 FOS KLF13 VAPA RAB31 TXNDC2 PPP4R1 RALBP1 RN7SL862P ZNF415P1
GH18G009848 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 -35.9 -35907 2.2 HDGF PKNOX1 ATF1 CREB3L1 ARNT ELK1 NCOA1 REST ZNF592 SREBF1 RAB31 VAPA TXNDC2 PPP4R1 RNA5SP449 PIGPP4
GH18G009735 2 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -145.3 -145270 9.0 HDGF HNRNPUL1 FOXA2 PKNOX1 CREB3L1 SIN3A FEZF1 YY1 ZNF766 FOS RAB31 TXNDC2 PPP4R1 RNU6-903P VAPA ENSG00000266891 GC18M009550
GH18G009854 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13 -30.4 -30389 2.2 ELF3 FOXA2 MLX THRB RAD21 RARA GATA4 MIXL1 THAP11 HMG20B VAPA TXNDC2 RAB31 PPP4R1 RALBP1 RNA5SP449 PIGPP4
GH18G009755 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -128.3 -128271 4.3 HDGF PKNOX1 ARNT ELK1 GATA2 CBX5 FOS KDM4B REST ZNF592 RAB31 TXNDC2 VAPA PPP4R1 ENSG00000266891 GC18M009550
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TXNDC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TXNDC2 Gene

Chromosome:
18
Start:
9,885,726 bp from pter
End:
9,889,275 bp from pter
Size:
3,550 bases
Orientation:
Plus strand

Genomic View for TXNDC2 Gene

Genes around TXNDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC2 Gene

Proteins for TXNDC2 Gene

  • Protein details for TXNDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VQ3-TXND2_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 2
    Protein Accession:
    Q86VQ3
    Secondary Accessions:
    • A5YM73
    • Q8N7U4
    • Q96RX3
    • Q9H0L8

    Protein attributes for TXNDC2 Gene

    Size:
    553 amino acids
    Molecular mass:
    60404 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TXNDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TXNDC2 Gene

Post-translational modifications for TXNDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TXNDC2 Gene

No data available for DME Specific Peptides for TXNDC2 Gene

Domains & Families for TXNDC2 Gene

Protein Domains for TXNDC2 Gene

Suggested Antigen Peptide Sequences for TXNDC2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TXNDC2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TXNDC2 Gene

Function for TXNDC2 Gene

Molecular function for TXNDC2 Gene

UniProtKB/Swiss-Prot Function:
Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

Gene Ontology (GO) - Molecular Function for TXNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004791 thioredoxin-disulfide reductase activity ISS --
GO:0015035 protein disulfide oxidoreductase activity IBA --
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA --
GO:0047134 protein-disulfide reductase activity IBA --
genes like me logo Genes that share ontologies with TXNDC2: view
genes like me logo Genes that share phenotypes with TXNDC2: view

Animal Models for TXNDC2 Gene

MGI Knock Outs for TXNDC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TXNDC2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TXNDC2 Gene

Localization for TXNDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC2 Gene

Cytoplasm. Note=In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNDC2 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 2
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TXNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001520 outer dense fiber IEA --
GO:0005623 cell IEA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TXNDC2: view

Pathways & Interactions for TXNDC2 Gene

SuperPathways for TXNDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006662 glycerol ether metabolic process IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis NAS 11399755
GO:0030154 cell differentiation IEA --
GO:0034599 cellular response to oxidative stress IBA --
genes like me logo Genes that share ontologies with TXNDC2: view

No data available for Pathways by source and SIGNOR curated interactions for TXNDC2 Gene

Drugs & Compounds for TXNDC2 Gene

(2) Additional Compounds for TXNDC2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with TXNDC2: view

Transcripts for TXNDC2 Gene

Unigene Clusters for TXNDC2 Gene

Thioredoxin domain containing 2 (spermatozoa):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for TXNDC2 Gene

GeneLoc Exon Structure for
TXNDC2
ECgene alternative splicing isoforms for
TXNDC2

Expression for TXNDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNDC2 Gene

mRNA differential expression in normal tissues according to GTEx for TXNDC2 Gene

This gene is overexpressed in Testis (x50.5).

Protein differential expression in normal tissues from HIPED for TXNDC2 Gene

This gene is overexpressed in Ovary (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TXNDC2 Gene



Protein tissue co-expression partners for TXNDC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TXNDC2 Gene:

TXNDC2

SOURCE GeneReport for Unigene cluster for TXNDC2 Gene:

Hs.98712

mRNA Expression by UniProt/SwissProt for TXNDC2 Gene:

Q86VQ3-TXND2_HUMAN
Tissue specificity: Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids.

Evidence on tissue expression from TISSUES for TXNDC2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TXNDC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNDC2 Gene

Orthologs for TXNDC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TXNDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNDC2 34 35
  • 97.63 (n)
dog
(Canis familiaris)
Mammalia TXNDC2 34 35
  • 71.2 (n)
cow
(Bos Taurus)
Mammalia TXNDC2 34 35
  • 69.39 (n)
rat
(Rattus norvegicus)
Mammalia Txndc2 34
  • 69.38 (n)
mouse
(Mus musculus)
Mammalia Txndc2 34 16 35
  • 68.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves TXN 35
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 52 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii txn 35
  • 50 (a)
ManyToMany
zgc:56493 35
  • 44 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10782 34
fruit fly
(Drosophila melanogaster)
Insecta Trx-2 35
  • 42 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trx-1 35
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRX2 35
  • 32 (a)
ManyToMany
TRX3 35
  • 31 (a)
ManyToMany
TRX1 35
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11205 35
  • 38 (a)
ManyToMany
Species where no ortholog for TXNDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TXNDC2 Gene

ENSEMBL:
Gene Tree for TXNDC2 (if available)
TreeFam:
Gene Tree for TXNDC2 (if available)

Paralogs for TXNDC2 Gene

Paralogs for TXNDC2 Gene

genes like me logo Genes that share paralogs with TXNDC2: view

Variants for TXNDC2 Gene

Sequence variations from dbSNP and Humsavar for TXNDC2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000577340 -- 9,889,558(+) TCAAA(C/T)ATCAG downstream-variant-500B
rs1001615819 -- 9,885,407(+) AGTGG(A/T)CCTGA upstream-variant-2KB
rs1003690898 -- 9,885,800(+) CTGGA(C/T)GGGAC utr-variant-5-prime
rs1004037177 -- 9,888,367(+) CATGG(C/T)GAAGA intron-variant, utr-variant-3-prime
rs1004072626 -- 9,886,493(+) CATCA(A/G)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC2 Gene

Variant ID Type Subtype PubMed ID
esv2716777 CNV deletion 23290073
esv2716778 CNV deletion 23290073
nsv527829 CNV gain 19592680
nsv833586 CNV loss 17160897

Variation tolerance for TXNDC2 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.93; 91.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC2 Gene

Disorders for TXNDC2 Gene

Relevant External Links for TXNDC2

Genetic Association Database (GAD)
TXNDC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXNDC2

No disorders were found for TXNDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC2 Gene

Publications for TXNDC2 Gene

  1. Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa. (PMID: 11399755) Miranda-Vizuete A. … Spyrou G. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity. (PMID: 12387870) Jimenez A. … Miranda-Vizuete A. (FEBS Lett. 2002) 3 4 22 64
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TXNDC2 Gene

Sources for TXNDC2 Gene

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