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TXNDC17 Gene

protein-coding   GIFtS: 46
GCID: GC17P006486

Thioredoxin Domain Containing 17

(Previous name: thioredoxin-like 5)
(Previous symbol: TXNL5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin Domain Containing 171 2     TRP142 3
TXNL51 2 3     14 KDa1
Thioredoxin-Like 51 2     Thioredoxin (Trx)-Related Protein1
Protein 42-9-92 3     Thioredoxin (Trx)-Related Protein, 14 KDa2
Thioredoxin-Like Protein 52 3     Thioredoxin Domain-Containing Protein 172
14 KDa Thioredoxin-Related Protein2 3     

External Ids:    HGNC: 282181   Entrez Gene: 848172   Ensembl: ENSG000001292357   UniProtKB: Q9BRA23   

Export aliases for TXNDC17 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TXNDC17 Gene:
TXNDC17 (thioredoxin domain containing 17) is a protein-coding gene. Diseases associated with TXNDC17 include tonsillitis, and malaria. GO annotations related to this gene include electron carrier activity and protein-disulfide reductase activity.

UniProtKB/Swiss-Prot: TXD17_HUMAN, Q9BRA2
Function: Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its
active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha
signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular
hydrogen peroxide




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TXNDC17 gene promoter:
         Max1   USF1   Pax-5   HSF1 (long)   YY1   HSF2   USF-1   HSF1short   c-Myc   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXNDC17 promoter sequence
   Search Chromatin IP Primers for TXNDC17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXNDC17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.2

TXNDC17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNDC17 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P006486:  view genomic region     (about GC identifiers)

Start:
6,544,078 bp from pter      End:
6,547,861 bp from pter
Size:
3,784 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TXD17_HUMAN, Q9BRA2 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 17  
Size: 123 amino acids; 13941 Da
Subunit: Interacts with TRXR1 and DYNLL1/DNCL1
1 PDB 3D structure from and Proteopedia for TXNDC17:
1WOU (3D)    
Secondary accessions: A8K7E8

Explore the universe of human proteins at neXtProt for TXNDC17: NX_Q9BRA2

Explore proteomics data for TXNDC17 at MOPED

Post-translational modifications: 

  • The oxidized protein is reduced by TRXR11
  • Ubiquitination2 at Lys25, Lys35, Lys40, Lys78, Lys98
  • Modification sites at PhosphoSitePlus

  • See TXNDC17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116120.1  
    ENSEMBL proteins: 
     ENSP00000250101   ENSP00000459868   ENSP00000458157   ENSP00000460577  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR010357 DUF953_thioredox

    Graphical View of Domain Structure for InterPro Entry Q9BRA2

    ProtoNet protein and cluster: Q9BRA2

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TXD17_HUMAN, Q9BRA2
    Similarity: Belongs to the thioredoxin family
    Similarity: Contains 1 thioredoxin domain


    TXNDC17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXD17_HUMAN, Q9BRA2
    Function: Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its
    active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha
    signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular
    hydrogen peroxide

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004601peroxidase activity IDA14607844
    GO:0005515protein binding IPI14607844
    GO:0009055electron carrier activity IDA15355959
    GO:0047134protein-disulfide reductase activity IDA14607844
         
    TXNDC17 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TXNDC17
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TXNDC17 (see all 10):
    hsa-miR-569 hsa-let-7a-2* hsa-miR-410 hsa-miR-633 hsa-miR-493* hsa-let-7g* hsa-miR-2114* hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidTXNDC17 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TXD17_HUMAN, Q9BRA2: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular2
    cytoskeleton1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA14607844
    GO:0070062extracellular vesicular exosome IDA19056867

    TXNDC17 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TXNDC17
    Interactions:

        GeneGlobe Interaction Network for TXNDC17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for TXNDC17 (Q9BRA23 ENSP000002501014) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OXTP011783, ENSP000002173864I2D: score=2 STRING: ENSP00000217386
    CFL1P235283, ENSP000003096294I2D: score=1 STRING: ENSP00000309629
    DYNLL1P631673, ENSP000002425774I2D: score=2 STRING: ENSP00000242577
    TXNRD1Q168813, ENSP000004120454I2D: score=1 STRING: ENSP00000412045
    AVPP011853, ENSP000003696474I2D: score=2 STRING: ENSP00000369647
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033209tumor necrosis factor-mediated signaling pathway IMP14607844
    GO:0055114oxidation-reduction process IDA14607844

    TXNDC17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TXNDC17 (TXD17)

    1 Novoseek inferred chemical compound relationship for TXNDC17 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 53 3 14607843 (1), 19628032 (1)



    TXNDC17 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TXNDC17 gene: 
    NM_032731.3  

    Unigene Cluster for TXNDC17:

    Thioredoxin domain containing 17
    Hs.408236  [show with all ESTs]
    Unigene Representative Sequence: BC050406
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250101(uc002gdf.4) ENST00000576020 ENST00000570330 ENST00000574429
    ENST00000571957 ENST00000574734 ENST00000574838 ENST00000577146 ENST00000573792
    ENST00000571029
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TXNDC17 (see all 10):
    hsa-miR-569 hsa-let-7a-2* hsa-miR-410 hsa-miR-633 hsa-miR-493* hsa-let-7g* hsa-miR-2114* hsa-miR-330-3p
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      QuantiTect SYBR Green Assays in human, mouse, rat TXNDC17
      QuantiFast Probe-based Assays in human, mouse, rat TXNDC17

    Additional mRNA sequence: 

    AF086210.1 AJ344101.1 AK092749.1 AK291963.1 AK311853.1 BC006405.2 BC050406.1 

    10 DOTS entries:

    DT.97820955  DT.100686051  DT.95295883  DT.95295879  DT.120964602  DT.100806068  DT.120964694  DT.86852654 
    DT.100806063  DT.92435559 

    Selected AceView cDNA sequences (see all 221):

    BG177809 CA430100 AA306255 BU553909 AF086210 BM456313 BI258563 BX094082 
    BQ276424 AA579889 BG121391 BM744657 BG163595 AI167696 AA749335 AI383703 
    CA436586 BF437557 AA769576 CA434203 AI432629 BI862119 CR599070 Z39119 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC17    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
    SP1:                                      -           -               
    SP2:                          -           -           -               
    SP3:                                                  -               
    SP4:                                      -                           


    ECgene alternative splicing isoforms for TXNDC17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TXNDC17 expression in normal human tissues (normalized intensities)      TXNDC17 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGCAATAA
    TXNDC17 Expression
    About this image


    TXNDC17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
    TXNDC17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TXNDC17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408236

    UniProtKB/Swiss-Prot: TXD17_HUMAN, Q9BRA2
    Tissue specificity: Ubiquitously expressed in cell lines

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TXNDC17 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txndc171 , 5 thioredoxin domain containing 171, 5 83.47(n)1
    80.49(a)1
      11 (43.92 cM)5
    527001  NM_026559.31  NP_080835.11 
     722075475 
    chicken
    (Gallus gallus)
    Aves TXNDC171 thioredoxin domain containing 17 67.22(n)
    63.33(a)
      417680  XM_415925.3  XP_415925.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.13822 Transcribed sequence with weak similarity to protein more 69.98(n)    AL880618.2 
    zebrafish
    (Danio rerio)
    Actinopterygii txndc171 thioredoxin domain containing 17 64.5(n)
    69.11(a)
      445062  NM_001003456.1  NP_001003456.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cl1 clot 50.86(n)
    43.1(a)
      43938  NM_001273169.1  NP_001260098.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AR.16
    Protein Y71H2AR.1 (Y71H2AR.1) mRNA, complete cds
    39(a)
    1 ↔ 1
    III(2834663-2836261) WBGene00022188


    ENSEMBL Gene Tree for TXNDC17 (if available)
    TreeFam Gene Tree for TXNDC17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TXNDC17 gene

    TXNDC17 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TXNDC17
    PGOHUM00000244651 PGOHUM00000241130


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TXNDC17
    DNA2.0 Custom Variant and Variant Library Synthesis for TXNDC17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for TXNDC17:    About MalaCards
    tonsillitis    malaria    thyroiditis    prostatitis


    TXNDC17 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TXNDC17 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 27.2 3 14607843 (1), 15355959 (1), 19628032 (1)
    tumors 4.65 3 14607843 (1), 15355959 (1), 19628032 (1)


    Export disorders for TXNDC17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TXNDC17 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with TXNDC17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways. (PubMed id 14607843)1, 2, 3, 9 Jeong W.... Rhee S.G. (J. Biol. Chem. 2004)
    2. Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function. (PubMed id 14607844)1, 2, 3, 9 Jeong W.... Rhee S.G. (J. Biol. Chem. 2004)
    3. Structural basis of cellular redox regulation by human TRP14. (PubMed id 15355959)1, 2, 9 Woo J.R.... Ryu S.E. (J. Biol. Chem. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    Free Text  

      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84817 HGNC: 28218 AceView: TXNL5 Ensembl:ENSG00000129235 euGenes: HUgn84817
    ECgene: TXNDC17 H-InvDB: TXNDC17

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TXNDC17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TXNDC17 gene:
    Search GeneIP for patents involving TXNDC17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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