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Aliases for TXNDC17 Gene

Aliases for TXNDC17 Gene

  • Thioredoxin Domain Containing 17 2 3
  • 14 KDa Thioredoxin-Related Protein 3 4
  • Thioredoxin-Like Protein 5 3 4
  • Thioredoxin-Like 5 2 3
  • Protein 42-9-9 3 4
  • TXNL5 3 4
  • TRP14 3 4
  • Thioredoxin (Trx)-Related Protein, 14 KDa 3
  • Thioredoxin Domain-Containing Protein 17 3
  • Thioredoxin (Trx)-Related Protein 2
  • 14 KDa 2

External Ids for TXNDC17 Gene

Previous Symbols for TXNDC17 Gene

  • TXNL5

Summaries for TXNDC17 Gene

GeneCards Summary for TXNDC17 Gene

TXNDC17 (Thioredoxin Domain Containing 17) is a Protein Coding gene. GO annotations related to this gene include electron carrier activity and protein-disulfide reductase activity.

UniProtKB/Swiss-Prot for TXNDC17 Gene

  • Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC17 Gene

Genomics for TXNDC17 Gene

Genomic Location for TXNDC17 Gene

Start:
6,640,758 bp from pter
End:
6,644,541 bp from pter
Size:
3,784 bases
Orientation:
Plus strand

Genomic View for TXNDC17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXNDC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC17 Gene

Regulatory Elements for TXNDC17 Gene

Proteins for TXNDC17 Gene

  • Protein details for TXNDC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRA2-TXD17_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 17
    Protein Accession:
    Q9BRA2
    Secondary Accessions:
    • A8K7E8

    Protein attributes for TXNDC17 Gene

    Size:
    123 amino acids
    Molecular mass:
    13941 Da
    Quaternary structure:
    • Interacts with TRXR1 and DYNLL1/DNCL1.

    Three dimensional structures from OCA and Proteopedia for TXNDC17 Gene

neXtProt entry for TXNDC17 Gene

Proteomics data for TXNDC17 Gene at MOPED

Post-translational modifications for TXNDC17 Gene

  • The oxidized protein is reduced by TRXR1
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys25, Lys35, Lys40, Lys78, and Lys98

Other Protein References for TXNDC17 Gene

No data available for DME Specific Peptides for TXNDC17 Gene

Domains for TXNDC17 Gene

Protein Domains for TXNDC17 Gene

UniProtKB/Swiss-Prot:

TXD17_HUMAN
Domain:
  • Contains 1 thioredoxin domain.:
    • Q9BRA2
Family:
  • Belongs to the thioredoxin family.:
    • Q9BRA2
genes like me logo Genes that share domains with TXNDC17: view

No data available for Gene Families for TXNDC17 Gene

Function for TXNDC17 Gene

Molecular function for TXNDC17 Gene

UniProtKB/Swiss-Prot Function: Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.

Gene Ontology (GO) - Molecular Function for TXNDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IDA 14607844
GO:0005515 protein binding IPI 14607844
GO:0009055 electron carrier activity IDA 15355959
GO:0047134 protein-disulfide reductase activity IDA 14607844
genes like me logo Genes that share ontologies with TXNDC17: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TXNDC17 Gene

Localization for TXNDC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC17 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXNDC17 Gene COMPARTMENTS Subcellular localization image for TXNDC17 gene
Compartment Confidence
cytosol 5
extracellular 2
cytoskeleton 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TXNDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 14607844
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TXNDC17: view

Pathways for TXNDC17 Gene

SuperPathways for TXNDC17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033209 tumor necrosis factor-mediated signaling pathway IMP 14607844
GO:0055114 oxidation-reduction process IDA 14607844
genes like me logo Genes that share ontologies with TXNDC17: view

No data available for Pathways by source for TXNDC17 Gene

Compounds for TXNDC17 Gene

(1) Novoseek inferred chemical compound relationships for TXNDC17 Gene

Compound -log(P) Hits PubMed IDs
cysteine 53 2
genes like me logo Genes that share compounds with TXNDC17: view

Transcripts for TXNDC17 Gene

Unigene Clusters for TXNDC17 Gene

Thioredoxin domain containing 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for TXNDC17 Gene

GeneLoc Exon Structure for
TXNDC17
ECgene alternative splicing isoforms for
TXNDC17

Expression for TXNDC17 Gene

mRNA expression in normal human tissues for TXNDC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TXNDC17 Gene

This gene is overexpressed in Esophagus - Mucosa (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXNDC17 Gene

SOURCE GeneReport for Unigene cluster for TXNDC17 Gene Hs.408236

mRNA Expression by UniProt/SwissProt for TXNDC17 Gene

Q9BRA2-TXD17_HUMAN
Tissue specificity: Ubiquitously expressed in cell lines.
genes like me logo Genes that share expressions with TXNDC17: view

Orthologs for TXNDC17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TXNDC17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNDC17 36
  • 99.73 (n)
  • 100 (a)
TXNDC17 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TXNDC17 36
  • 92.41 (n)
  • 90.24 (a)
TXNDC17 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Txndc17 36
  • 83.47 (n)
  • 80.49 (a)
Txndc17 16
Txndc17 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TXNDC17 37
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 72 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Txndc17 36
  • 82.11 (n)
  • 79.67 (a)
chicken
(Gallus gallus)
Aves TXNDC17 36
  • 67.22 (n)
  • 63.33 (a)
TXNDC17 37
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1382 36
txndc17 36
  • 67.21 (n)
  • 65.85 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9763 36
zebrafish
(Danio rerio)
Actinopterygii txndc17 36
  • 64.5 (n)
  • 69.11 (a)
txndc17 37
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GRX3 36
  • 52.34 (n)
  • 45.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3939 37
  • 29 (a)
OneToMany
cl 36
  • 50.86 (n)
  • 43.1 (a)
cl 37
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AR.1 37
  • 39 (a)
OneToOne
Species with no ortholog for TXNDC17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNDC17 Gene

ENSEMBL:
Gene Tree for TXNDC17 (if available)
TreeFam:
Gene Tree for TXNDC17 (if available)

Paralogs for TXNDC17 Gene

Pseudogenes.org Pseudogenes for TXNDC17 Gene

genes like me logo Genes that share paralogs with TXNDC17: view

No data available for Paralogs for TXNDC17 Gene

Variants for TXNDC17 Gene

Relevant External Links for TXNDC17 Gene

HapMap Linkage Disequilibrium report
TXNDC17

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TXNDC17 Gene

Disorders for TXNDC17 Gene

(2) Novoseek inferred disease relationships for TXNDC17 Gene

Disease -log(P) Hits PubMed IDs
necrosis 27.2 3
tumors 4.65 3
genes like me logo Genes that share disorders with TXNDC17: view

No data available for UniProtKB/Swiss-Prot for TXNDC17 Gene

Publications for TXNDC17 Gene

  1. Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways. (PMID: 14607843) Jeong W. … Rhee S.G. (J. Biol. Chem. 2004) 2 3 4 23
  2. Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function. (PMID: 14607844) Jeong W. … Rhee S.G. (J. Biol. Chem. 2004) 2 3 4 23
  3. Structural basis of cellular redox regulation by human TRP14. (PMID: 15355959) Woo J.R. … Ryu S.E. (J. Biol. Chem. 2004) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha. (PMID: 18579519) Jung Y. … Jeong W. (J. Biol. Chem. 2008) 3

Products for TXNDC17 Gene

Sources for TXNDC17 Gene

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