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Aliases for TXNDC17 Gene

Aliases for TXNDC17 Gene

  • Thioredoxin Domain Containing 17 2 3
  • 14 KDa Thioredoxin-Related Protein 3 4
  • Thioredoxin-Like Protein 5 3 4
  • Thioredoxin-Like 5 2 3
  • Protein 42-9-9 3 4
  • TXNL5 3 4
  • TRP14 3 4
  • Thioredoxin (Trx)-Related Protein, 14 KDa 3
  • Thioredoxin Domain-Containing Protein 17 3
  • Thioredoxin (Trx)-Related Protein 2
  • 14 KDa 2

External Ids for TXNDC17 Gene

Previous HGNC Symbols for TXNDC17 Gene

  • TXNL5

Previous GeneCards Identifiers for TXNDC17 Gene

  • GC17P006486

Summaries for TXNDC17 Gene

GeneCards Summary for TXNDC17 Gene

TXNDC17 (Thioredoxin Domain Containing 17) is a Protein Coding gene. GO annotations related to this gene include electron carrier activity and protein-disulfide reductase activity.

UniProtKB/Swiss-Prot for TXNDC17 Gene

  • Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC17 Gene

Genomics for TXNDC17 Gene

Regulatory Elements for TXNDC17 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TXNDC17 Gene

Start:
6,640,758 bp from pter
End:
6,644,541 bp from pter
Size:
3,784 bases
Orientation:
Plus strand

Genomic View for TXNDC17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXNDC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC17 Gene

Proteins for TXNDC17 Gene

  • Protein details for TXNDC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRA2-TXD17_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 17
    Protein Accession:
    Q9BRA2
    Secondary Accessions:
    • A8K7E8

    Protein attributes for TXNDC17 Gene

    Size:
    123 amino acids
    Molecular mass:
    13941 Da
    Quaternary structure:
    • Interacts with TRXR1 and DYNLL1/DNCL1.

    Three dimensional structures from OCA and Proteopedia for TXNDC17 Gene

neXtProt entry for TXNDC17 Gene

Proteomics data for TXNDC17 Gene at MOPED

Post-translational modifications for TXNDC17 Gene

  • The oxidized protein is reduced by TRXR1
  • Ubiquitination at Lys25, Lys35, Lys40, Lys78, and Lys98
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNDC17 Gene

Antibody Products

  • R&D Systems Antibodies for TXNDC17 (Thioredoxin-like 5/TRP14)

No data available for DME Specific Peptides for TXNDC17 Gene

Domains for TXNDC17 Gene

Protein Domains for TXNDC17 Gene

Suggested Antigen Peptide Sequences for TXNDC17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRA2

UniProtKB/Swiss-Prot:

TXD17_HUMAN :
  • Q9BRA2
Domain:
  • Contains 1 thioredoxin domain.
Family:
  • Belongs to the thioredoxin family.
genes like me logo Genes that share domains with TXNDC17: view

No data available for Gene Families for TXNDC17 Gene

Function for TXNDC17 Gene

Molecular function for TXNDC17 Gene

UniProtKB/Swiss-Prot Function:
Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.

Gene Ontology (GO) - Molecular Function for TXNDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IDA 14607844
GO:0005515 protein binding IPI 14607844
GO:0009055 electron carrier activity IDA 15355959
GO:0047134 protein-disulfide reductase activity IDA 14607844
genes like me logo Genes that share ontologies with TXNDC17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXNDC17

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TXNDC17 Gene

Localization for TXNDC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC17 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXNDC17 Gene COMPARTMENTS Subcellular localization image for TXNDC17 gene
Compartment Confidence
cytosol 5
extracellular 2
cytoskeleton 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TXNDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 14607844
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TXNDC17: view

Pathways for TXNDC17 Gene

SuperPathways for TXNDC17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033209 tumor necrosis factor-mediated signaling pathway IMP 14607844
GO:0055114 oxidation-reduction process IDA 14607844
genes like me logo Genes that share ontologies with TXNDC17: view

No data available for Pathways by source for TXNDC17 Gene

Compounds for TXNDC17 Gene

(1) Novoseek inferred chemical compound relationships for TXNDC17 Gene

Compound -log(P) Hits PubMed IDs
cysteine 53 2
genes like me logo Genes that share compounds with TXNDC17: view

Transcripts for TXNDC17 Gene

mRNA/cDNA for TXNDC17 Gene

Unigene Clusters for TXNDC17 Gene

Thioredoxin domain containing 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXNDC17

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for TXNDC17 Gene

GeneLoc Exon Structure for
TXNDC17
ECgene alternative splicing isoforms for
TXNDC17

Expression for TXNDC17 Gene

mRNA expression in normal human tissues for TXNDC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TXNDC17 Gene

This gene is overexpressed in Esophagus - Mucosa (6.2).

Protein differential expression in normal tissues for TXNDC17 Gene

This gene is overexpressed in Oral epithelium (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXNDC17 Gene

SOURCE GeneReport for Unigene cluster for TXNDC17 Gene Hs.408236

mRNA Expression by UniProt/SwissProt for TXNDC17 Gene

Q9BRA2-TXD17_HUMAN
Tissue specificity: Ubiquitously expressed in cell lines.
genes like me logo Genes that share expressions with TXNDC17: view

Expression partners for TXNDC17 Gene

In Situ Assay Products

Orthologs for TXNDC17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TXNDC17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TXNDC17 35
  • 92.41 (n)
  • 90.24 (a)
TXNDC17 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Txndc17 35
  • 83.47 (n)
  • 80.49 (a)
Txndc17 16
Txndc17 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TXNDC17 35
  • 99.73 (n)
  • 100 (a)
TXNDC17 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Txndc17 35
  • 82.11 (n)
  • 79.67 (a)
oppossum
(Monodelphis domestica)
Mammalia TXNDC17 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves TXNDC17 35
  • 67.22 (n)
  • 63.33 (a)
TXNDC17 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1382 35
txndc17 35
  • 67.21 (n)
  • 65.85 (a)
zebrafish
(Danio rerio)
Actinopterygii txndc17 35
  • 64.5 (n)
  • 69.11 (a)
txndc17 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9763 35
African malaria mosquito
(Anopheles gambiae)
Insecta GRX3 35
  • 52.34 (n)
  • 45.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta cl 35
  • 50.86 (n)
  • 43.1 (a)
CG3939 36
  • 29 (a)
OneToMany
cl 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AR.1 36
  • 39 (a)
OneToOne
Species with no ortholog for TXNDC17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNDC17 Gene

ENSEMBL:
Gene Tree for TXNDC17 (if available)
TreeFam:
Gene Tree for TXNDC17 (if available)

Paralogs for TXNDC17 Gene

Pseudogenes.org Pseudogenes for TXNDC17 Gene

genes like me logo Genes that share paralogs with TXNDC17: view

No data available for Paralogs for TXNDC17 Gene

Variants for TXNDC17 Gene

Relevant External Links for TXNDC17 Gene

HapMap Linkage Disequilibrium report
TXNDC17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TXNDC17 Gene

Disorders for TXNDC17 Gene

(2) Novoseek inferred disease relationships for TXNDC17 Gene

Disease -log(P) Hits PubMed IDs
necrosis 27.2 3
tumors 4.65 3
genes like me logo Genes that share disorders with TXNDC17: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for TXNDC17 Gene

Publications for TXNDC17 Gene

  1. Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways. (PMID: 14607843) Jeong W. … Rhee S.G. (J. Biol. Chem. 2004) 2 3 4 23
  2. Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function. (PMID: 14607844) Jeong W. … Rhee S.G. (J. Biol. Chem. 2004) 2 3 4 23
  3. Structural basis of cellular redox regulation by human TRP14. (PMID: 15355959) Woo J.R. … Ryu S.E. (J. Biol. Chem. 2004) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha. (PMID: 18579519) Jung Y. … Jeong W. (J. Biol. Chem. 2008) 3

Products for TXNDC17 Gene

Sources for TXNDC17 Gene

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