Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TXNDC17 Gene

Aliases for TXNDC17 Gene

  • Thioredoxin Domain Containing 17 2 3 5
  • 14 KDa Thioredoxin-Related Protein 3 4
  • Thioredoxin-Like Protein 5 3 4
  • Thioredoxin-Like 5 2 3
  • Protein 42-9-9 3 4
  • TXNL5 3 4
  • TRP14 3 4
  • Thioredoxin (Trx)-Related Protein, 14 KDa 3
  • Thioredoxin (Trx)-Related Protein 2
  • Testicular Tissue Protein Li 214 3
  • 14 KDa 2

External Ids for TXNDC17 Gene

Previous HGNC Symbols for TXNDC17 Gene

  • TXNL5

Previous GeneCards Identifiers for TXNDC17 Gene

  • GC17P006486

Summaries for TXNDC17 Gene

GeneCards Summary for TXNDC17 Gene

TXNDC17 (Thioredoxin Domain Containing 17) is a Protein Coding gene. GO annotations related to this gene include electron carrier activity and protein-disulfide reductase activity.

UniProtKB/Swiss-Prot for TXNDC17 Gene

  • Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC17 Gene

Genomics for TXNDC17 Gene

Regulatory Elements for TXNDC17 Gene

Promoters for TXNDC17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TXNDC17 on UCSC Golden Path with GeneCards custom track

Genomic Location for TXNDC17 Gene

Chromosome:
17
Start:
6,640,758 bp from pter
End:
6,644,541 bp from pter
Size:
3,784 bases
Orientation:
Plus strand

Genomic View for TXNDC17 Gene

Genes around TXNDC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC17 Gene

Proteins for TXNDC17 Gene

  • Protein details for TXNDC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRA2-TXD17_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 17
    Protein Accession:
    Q9BRA2
    Secondary Accessions:
    • A8K7E8

    Protein attributes for TXNDC17 Gene

    Size:
    123 amino acids
    Molecular mass:
    13941 Da
    Quaternary structure:
    • Interacts with TRXR1 and DYNLL1/DNCL1.

    Three dimensional structures from OCA and Proteopedia for TXNDC17 Gene

neXtProt entry for TXNDC17 Gene

Proteomics data for TXNDC17 Gene at MOPED

Post-translational modifications for TXNDC17 Gene

  • The oxidized protein is reduced by TRXR1.
  • Ubiquitination at Lys 25, Lys 35, Lys 40, Lys 78, and Lys 98
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNDC17 Gene

Antibody Products

  • R&D Systems Antibodies for TXNDC17 (Thioredoxin-like 5/TRP14)

No data available for DME Specific Peptides for TXNDC17 Gene

Domains & Families for TXNDC17 Gene

Protein Domains for TXNDC17 Gene

Suggested Antigen Peptide Sequences for TXNDC17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRA2

UniProtKB/Swiss-Prot:

TXD17_HUMAN :
  • Contains 1 thioredoxin domain.
  • Belongs to the thioredoxin family.
Domain:
  • Contains 1 thioredoxin domain.
Family:
  • Belongs to the thioredoxin family.
genes like me logo Genes that share domains with TXNDC17: view

No data available for Gene Families for TXNDC17 Gene

Function for TXNDC17 Gene

Molecular function for TXNDC17 Gene

UniProtKB/Swiss-Prot Function:
Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.

Gene Ontology (GO) - Molecular Function for TXNDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IDA 14607844
GO:0005515 protein binding IPI 14607844
genes like me logo Genes that share ontologies with TXNDC17: view
genes like me logo Genes that share phenotypes with TXNDC17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNDC17 Gene

Localization for TXNDC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC17 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXNDC17 Gene COMPARTMENTS Subcellular localization image for TXNDC17 gene
Compartment Confidence
cytosol 5
extracellular 5
cytoskeleton 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TXNDC17 Gene

Pathways & Interactions for TXNDC17 Gene

SuperPathways for TXNDC17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098869 cellular oxidant detoxification IDA 14607844
genes like me logo Genes that share ontologies with TXNDC17: view

No data available for Pathways by source and SIGNOR curated interactions for TXNDC17 Gene

Drugs & Compounds for TXNDC17 Gene

(1) Drugs for TXNDC17 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TXNDC17: view

Transcripts for TXNDC17 Gene

Unigene Clusters for TXNDC17 Gene

Thioredoxin domain containing 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for TXNDC17 Gene

GeneLoc Exon Structure for
TXNDC17
ECgene alternative splicing isoforms for
TXNDC17

Expression for TXNDC17 Gene

mRNA expression in normal human tissues for TXNDC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TXNDC17 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.2).

Protein differential expression in normal tissues from HIPED for TXNDC17 Gene

This gene is overexpressed in Oral epithelium (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXNDC17 Gene



SOURCE GeneReport for Unigene cluster for TXNDC17 Gene Hs.408236

mRNA Expression by UniProt/SwissProt for TXNDC17 Gene

Q9BRA2-TXD17_HUMAN
Tissue specificity: Ubiquitously expressed in cell lines.
genes like me logo Genes that share expression patterns with TXNDC17: view

Protein tissue co-expression partners for TXNDC17 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TXNDC17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TXNDC17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNDC17 36
  • 100 (a)
OneToOne
TXNDC17 35
  • 99.73 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TXNDC17 36
  • 90 (a)
OneToOne
TXNDC17 35
  • 92.41 (n)
  • 90.24 (a)
mouse
(Mus musculus)
Mammalia Txndc17 35
  • 83.47 (n)
  • 80.49 (a)
Txndc17 16
Txndc17 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TXNDC17 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Txndc17 35
  • 82.11 (n)
  • 79.67 (a)
chicken
(Gallus gallus)
Aves TXNDC17 35
  • 67.22 (n)
  • 63.33 (a)
TXNDC17 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1382 35
txndc17 35
  • 67.21 (n)
  • 65.85 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9763 35
zebrafish
(Danio rerio)
Actinopterygii txndc17 36
  • 69 (a)
OneToOne
txndc17 35
  • 64.5 (n)
  • 69.11 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GRX3 35
  • 52.34 (n)
  • 45.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3939 36
  • 29 (a)
OneToMany
cl 36
  • 37 (a)
OneToMany
cl 35
  • 50.86 (n)
  • 43.1 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71H2AR.1 36
  • 39 (a)
OneToOne
Species with no ortholog for TXNDC17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNDC17 Gene

ENSEMBL:
Gene Tree for TXNDC17 (if available)
TreeFam:
Gene Tree for TXNDC17 (if available)

Paralogs for TXNDC17 Gene

Pseudogenes.org Pseudogenes for TXNDC17 Gene

genes like me logo Genes that share paralogs with TXNDC17: view

No data available for Paralogs for TXNDC17 Gene

Variants for TXNDC17 Gene

Variation tolerance for TXNDC17 Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNDC17 Gene

HapMap Linkage Disequilibrium report
TXNDC17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TXNDC17 Gene

Disorders for TXNDC17 Gene

Relevant External Links for TXNDC17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXNDC17

No disorders were found for TXNDC17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC17 Gene

Publications for TXNDC17 Gene

  1. Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways. (PMID: 14607843) Jeong W. … Rhee S.G. (J. Biol. Chem. 2004) 2 3 4 23 67
  2. Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function. (PMID: 14607844) Jeong W. … Rhee S.G. (J. Biol. Chem. 2004) 2 3 23
  3. Structural basis of cellular redox regulation by human TRP14. (PMID: 15355959) Woo J.R. … Ryu S.E. (J. Biol. Chem. 2004) 3 23
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TXNDC17 Gene

Sources for TXNDC17 Gene

Back to Top

Content