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Aliases for TXNDC17 Gene

Aliases for TXNDC17 Gene

  • Thioredoxin Domain Containing 17 2 3 5
  • Thioredoxin (Trx)-Related Protein, 14 KDa 2 3
  • 14 KDa Thioredoxin-Related Protein 3 4
  • Thioredoxin-Like Protein 5 3 4
  • Thioredoxin-Like 5 2 3
  • Protein 42-9-9 3 4
  • TXNL5 3 4
  • TRP14 3 4
  • Thioredoxin Domain-Containing Protein 17 3
  • Testicular Tissue Protein Li 214 3

External Ids for TXNDC17 Gene

Previous HGNC Symbols for TXNDC17 Gene

  • TXNL5

Previous GeneCards Identifiers for TXNDC17 Gene

  • GC17P006486

Summaries for TXNDC17 Gene

GeneCards Summary for TXNDC17 Gene

TXNDC17 (Thioredoxin Domain Containing 17) is a Protein Coding gene. GO annotations related to this gene include electron carrier activity and protein-disulfide reductase activity.

UniProtKB/Swiss-Prot for TXNDC17 Gene

  • Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC17 Gene

Genomics for TXNDC17 Gene

Regulatory Elements for TXNDC17 Gene

Enhancers for TXNDC17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G006660 1 Ensembl dbSUPER 11.8 +20.2 20243 1.6 HDGF BMI1 ZFHX2 POLR2A EED ZNF600 ETV6 RELB IKZF2 CREM ENSG00000261996 TXNDC17 SLC13A5 PITPNM3 BCL6B TNK1 ALOX15P1 PIR54331 GC17P006673
GH17G006668 0.9 ENCODE 11.7 +29.6 29572 3.2 ELF3 NFIB KLF17 THRB ZNF48 RARA IKZF2 EGR2 ZBTB2 NCOA1 SLC13A5 TXNDC17 KIAA0753 FBXO39 TEKT1 BCL6B ENSG00000261996 CTDNEP1 GC17P006673 PIR54331
GH17G006599 0.9 Ensembl ENCODE 11 -41.1 -41138 1.2 L3MBTL2 MAFG MAX MNT ZNF316 FOXK2 SMARCA4 IKZF1 NFE2L1 NFE2 KIAA0753 PITPNM3 TXNDC17 C17orf100 MED31 SLC13A5 GC17M006601 RNA5SP435 GC17M006460
GH17G006666 0.8 ENCODE 11.8 +25.5 25519 0.4 GTF2F1 ELF3 CTCF SAP130 ARID4B CEBPG ZIC2 RAD21 RFX5 TEAD3 ENSG00000261996 KIAA0753 TXNDC17 SLC13A5 MIR195 PITPNM3 BCL6B ALOX15P1 GC17P006673 PIR54331
GH17G006505 1.3 Ensembl ENCODE dbSUPER 5.5 -132.3 -132309 6.0 BRCA1 RAD21 YY1 RFX5 ZNF366 GATA2 ZNF143 RCOR1 FOS EGR2 PITPNM3 TXNDC17 ENSG00000274860 PIR55314
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TXNDC17 on UCSC Golden Path with GeneCards custom track

Promoters for TXNDC17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090738 42 2401 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 DEK

Genomic Location for TXNDC17 Gene

Chromosome:
17
Start:
6,640,758 bp from pter
End:
6,644,541 bp from pter
Size:
3,784 bases
Orientation:
Plus strand

Genomic View for TXNDC17 Gene

Genes around TXNDC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC17 Gene

Proteins for TXNDC17 Gene

  • Protein details for TXNDC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRA2-TXD17_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 17
    Protein Accession:
    Q9BRA2
    Secondary Accessions:
    • A8K7E8

    Protein attributes for TXNDC17 Gene

    Size:
    123 amino acids
    Molecular mass:
    13941 Da
    Quaternary structure:
    • Interacts with TRXR1 and DYNLL1/DNCL1.

    Three dimensional structures from OCA and Proteopedia for TXNDC17 Gene

neXtProt entry for TXNDC17 Gene

Post-translational modifications for TXNDC17 Gene

  • The oxidized protein is reduced by TRXR1.
  • Ubiquitination at isoforms=25, Lys35, Lys40, isoforms=78, and Lys98
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNDC17 Gene

No data available for DME Specific Peptides for TXNDC17 Gene

Domains & Families for TXNDC17 Gene

Protein Domains for TXNDC17 Gene

Suggested Antigen Peptide Sequences for TXNDC17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRA2

UniProtKB/Swiss-Prot:

TXD17_HUMAN :
  • Belongs to the thioredoxin family.
Family:
  • Belongs to the thioredoxin family.
genes like me logo Genes that share domains with TXNDC17: view

No data available for Gene Families for TXNDC17 Gene

Function for TXNDC17 Gene

Molecular function for TXNDC17 Gene

UniProtKB/Swiss-Prot Function:
Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.

Gene Ontology (GO) - Molecular Function for TXNDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IDA 14607844
GO:0005515 protein binding IPI 14607844
GO:0047134 protein-disulfide reductase activity IDA 14607844
genes like me logo Genes that share ontologies with TXNDC17: view
genes like me logo Genes that share phenotypes with TXNDC17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNDC17 Gene

Localization for TXNDC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC17 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNDC17 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TXNDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 14607844
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TXNDC17: view

Pathways & Interactions for TXNDC17 Gene

SuperPathways for TXNDC17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033209 tumor necrosis factor-mediated signaling pathway IMP 14607844
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with TXNDC17: view

No data available for Pathways by source and SIGNOR curated interactions for TXNDC17 Gene

Drugs & Compounds for TXNDC17 Gene

(1) Drugs for TXNDC17 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TXNDC17: view

Transcripts for TXNDC17 Gene

Unigene Clusters for TXNDC17 Gene

Thioredoxin domain containing 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for TXNDC17 Gene

GeneLoc Exon Structure for
TXNDC17
ECgene alternative splicing isoforms for
TXNDC17

Expression for TXNDC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNDC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TXNDC17 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.2).

Protein differential expression in normal tissues from HIPED for TXNDC17 Gene

This gene is overexpressed in Oral epithelium (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXNDC17 Gene



Protein tissue co-expression partners for TXNDC17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TXNDC17 Gene:

TXNDC17

SOURCE GeneReport for Unigene cluster for TXNDC17 Gene:

Hs.408236

mRNA Expression by UniProt/SwissProt for TXNDC17 Gene:

Q9BRA2-TXD17_HUMAN
Tissue specificity: Ubiquitously expressed in cell lines.

Evidence on tissue expression from TISSUES for TXNDC17 Gene

  • Heart(4.4)
  • Skin(4.3)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with TXNDC17: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNDC17 Gene

Orthologs for TXNDC17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TXNDC17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNDC17 34 35
  • 99.73 (n)
cow
(Bos Taurus)
Mammalia TXNDC17 34 35
  • 92.41 (n)
mouse
(Mus musculus)
Mammalia Txndc17 34 16 35
  • 83.47 (n)
rat
(Rattus norvegicus)
Mammalia Txndc17 34
  • 82.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TXNDC17 35
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves TXNDC17 34 35
  • 67.22 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc17 34
  • 67.21 (n)
Str.1382 34
zebrafish
(Danio rerio)
Actinopterygii txndc17 34 35
  • 64.5 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9763 34
African malaria mosquito
(Anopheles gambiae)
Insecta GRX3 34
  • 52.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta cl 34 35
  • 50.86 (n)
CG3939 35
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AR.1 35
  • 39 (a)
OneToOne
Species where no ortholog for TXNDC17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNDC17 Gene

ENSEMBL:
Gene Tree for TXNDC17 (if available)
TreeFam:
Gene Tree for TXNDC17 (if available)

Paralogs for TXNDC17 Gene

Pseudogenes.org Pseudogenes for TXNDC17 Gene

genes like me logo Genes that share paralogs with TXNDC17: view

No data available for Paralogs for TXNDC17 Gene

Variants for TXNDC17 Gene

Sequence variations from dbSNP and Humsavar for TXNDC17 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000365108 -- 6,644,143(+) ATTCA(A/G)TATAC downstream-variant-500B, utr-variant-3-prime
rs1000788226 -- 6,639,355(+) CCACA(A/G)CCCCA intron-variant, upstream-variant-2KB
rs1001333311 -- 6,644,781(+) TAGTA(A/C)ACTCT intron-variant, downstream-variant-500B
rs1001380977 -- 6,640,174(+) GGGAC(A/G)TCCCT intron-variant, upstream-variant-2KB
rs1001413623 -- 6,639,900(+) TCCCC(A/G)GACCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TXNDC17 Gene

Variant ID Type Subtype PubMed ID
nsv574278 CNV gain 21841781

Variation tolerance for TXNDC17 Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNDC17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNDC17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC17 Gene

Disorders for TXNDC17 Gene

Relevant External Links for TXNDC17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXNDC17

No disorders were found for TXNDC17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC17 Gene

Publications for TXNDC17 Gene

  1. Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways. (PMID: 14607843) Jeong W. … Rhee S.G. (J. Biol. Chem. 2004) 2 3 4 22 64
  2. Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function. (PMID: 14607844) Jeong W. … Rhee S.G. (J. Biol. Chem. 2004) 2 3 4 22 64
  3. Structural basis of cellular redox regulation by human TRP14. (PMID: 15355959) Woo J.R. … Ryu S.E. (J. Biol. Chem. 2004) 3 4 22 64
  4. Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase. (PMID: 24778250) Pader I. … ArnAcr E.S. (Proc. Natl. Acad. Sci. U.S.A. 2014) 2 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TXNDC17 Gene

Sources for TXNDC17 Gene

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