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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TXNDC16 Gene

protein-coding   GIFtS: 45
GCID: GC14M052897

Thioredoxin Domain Containing 16

(Previous name: KIAA1344)
(Previous symbol: KIAA1344)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thioredoxin Domain Containing 161 2
KIAA13441 2 3
ERp902
Thioredoxin Domain-Containing Protein 162

External Ids:    HGNC: 199651   Entrez Gene: 575442   Ensembl: ENSG000000873017   UniProtKB: Q9P2K23   

Export aliases for TXNDC16 gene to outside databases

Previous GC identifers: GC14M051968 GC14M033057


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TXNDC16 Gene: 
TXNDC16 (thioredoxin domain containing 16) is a protein-coding gene. Diseases associated with TXNDC16 include orofacial cleft, and meningioma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TXNDC16 gene promoter:
         Oct-B1   oct-B2   NF-AT   MZF-1   NF-AT4   NF-AT2   NRF-2   FOXO4   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXNDC16 promoter sequence
   Search SABiosciences Chromatin IP Primers for TXNDC16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q22.1

TXNDC16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNDC16 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M052897:  view genomic region     (about GC identifiers)

Start:
52,897,308 bp from pter      End:
53,019,301 bp from pter
Size:
121,994 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TXD16_HUMAN, Q9P2K2 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 16 precursor  
Size: 825 amino acids; 93572 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=BAB14101.1; Type=Erroneous initiation;
Secondary accessions: A5PKW9 A7E260 A7MD07 B9EH67 Q9H9W7

Explore the universe of human proteins at neXtProt for TXNDC16: NX_Q9P2K2

Explore proteomics data for TXNDC16 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2K2

  • TXNDC16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TXNDC16 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001153519.1  NP_065835.2  

    ENSEMBL proteins: 
     ENSP00000281741   ENSP00000451619   ENSP00000450839  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    TXNDC16 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR013766 Thioredoxin_domain
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9P2K2

    ProtoNet protein and cluster: Q9P2K2

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TXD16_HUMAN, Q9P2K2
    Similarity: Contains 1 thioredoxin domain


    TXNDC16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for TXNDC16:
     Increased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TXNDC16 
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    SwitchGear 3'UTR luciferase reporter plasmidTXNDC16 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC16


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TXNDC16

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045454cell redox homeostasis IEA--

    TXNDC16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TXNDC16 (TXD16)

    Search CenterWatch for drugs/clinical trials and news about TXNDC16 / TXD16

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TXNDC16 gene (2 alternative transcripts): 
    NM_001160047.1  NM_020784.2  

    Unigene Cluster for TXNDC16:

    Thioredoxin domain containing 16
    Hs.532609  [show with all ESTs]
    Unigene Representative Sequence: NM_020784
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281741(uc010tqu.2 uc001wzs.3 uc010aoe.3) ENST00000554399
    ENST00000555312 ENST00000557374
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNDC16 (see all 9):
    hsa-miR-203 hsa-miR-576-5p hsa-miR-4307 hsa-miR-3065-5p hsa-miR-373* hsa-miR-3613-3p hsa-miR-3148 hsa-miR-616*
    SwitchGear 3'UTR luciferase reporter plasmidTXNDC16 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of TXNDC16 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC16

    Additional mRNA sequence: 

    AB037765.2 AK022563.1 AK097748.1 BC137081.1 BC137082.1 BC142650.1 BC144469.1 BC150205.1 
    BC152428.1 

    4 DOTS entries:

    DT.111618  DT.100747810  DT.423127  DT.100660440 

    24/57 AceView cDNA sequences (see all 57):

    AA903817 AL040840 AK022563 AU124110 AV646118 AI832055 AA909703 AA347473 
    AI333000 AA278675 BU616802 AA773166 BV169005 AA609723 AA765100 AA724711 
    AI140821 BG928131 AI453818 AA278257 H85222 AA347472 BX115108 AI018228 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TXNDC16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGCTTA
    TXNDC16 Expression
    About this image


    See TXNDC16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TXNDC16

    SOURCE GeneReport for Unigene cluster: Hs.532609
        SABiosciences Custom PCR Arrays for TXNDC16
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC16
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TXNDC16 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txndc161 , 5 thioredoxin domain containing 161, 5 80.73(n)1
    76.16(a)1
      14 (22.77 cM)5
    705611  NM_172597.21  NP_766185.11 
     451344485 
    chicken
    (Gallus gallus)
    Aves TXNDC161 thioredoxin domain containing 16 63.44(n)
    57.27(a)
      423584  XM_421472.3  XP_421472.3 
    lizard
    (Anolis carolinensis)
    Reptilia TXNDC166
    thioredoxin domain containing 16
    48(a)
    1 ↔ 1
    GL343764.1(90203-166317)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5569731 thioredoxin domain-containing protein 16-like 50.97(n)
    40.31(a)
      556973  XM_679925.3  XP_685017.3 


    ENSEMBL Gene Tree for TXNDC16 (if available)
    TreeFam Gene Tree for TXNDC16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2386 SNPs in TXNDC16 are shown (see all 2386)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852645771,2
    C--52896815(+) TAAAAA/CCACAA 2 -- int10--------
    rs1892218811,2
    C--52896867(+) TACTCA/GGGAGG 2 -- int10--------
    rs1811161111,2
    --52896871(+) CGGGAG/TGCTGA 2 -- int10--------
    rs1857114991,2
    --52896891(+) ATGGCA/GTGAAC 2 -- int10--------
    rs21252501,2
    C,A,H--52896929(-) TGGCGG/TGATCT 2 -- int12Minor allele frequency- T:0.25NA 4
    rs21252491,2
    C,A,H--52896931(-) AGTGGT/CGTGAT 2 -- int11Minor allele frequency- C:0.00NA 2
    rs1443371731,2
    --52896946(+) TCCAGA/CCTGGG 2 -- int10--------
    rs7813751,2
    C,A,H--52896997(-) CAGTAC/TTTTAT 2 -- int17Minor allele frequency- T:0.39NA WA CSA EA 364
    rs1460938581,2
    --52897102(+) CTTCAA/CTGAGC 2 -- int10--------
    rs1487308661,2
    C--52897139(+) CTTAGC/TTCCTA 2 -- int10--------

    HapMap Linkage Disequilibrium report for TXNDC16 (52897308 - 53019301 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TXNDC16:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664522CNV Deletion23128226
    esv1464286CNV Insertion17803354
    esv1116149CNV Insertion17803354
    nsv826954CNV Loss20364138
    esv2622229CNV Loss19546169
    nsv901951CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TXNDC16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for TXNDC16:    About MalaCards
    orofacial cleft    meningioma

    1 disease from the University of Copenhagen DISEASES database for TXNDC16:
    Meningioma

    TXNDC16 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TXNDC16

    Export disorders for TXNDC16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TXNDC16 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with TXNDC16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome wide study of maternal and parent-of-origin eff ects on the etiology of orofacial clefts. (PubMed id 22419666)1, 4 Shi M....Beaty T.H. (2012)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    4. Identification of 23 new prostate cancer susceptibilit y loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (2013)
    5. Identification of the PDI-family member ERp90 as an in teraction partner of ERFAD. (PubMed id 21359175)1 Riemer J....Ellgaard L. (2011)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57544 HGNC: 19965 AceView: KIAA1344 Ensembl:ENSG00000087301 euGenes: HUgn57544
    ECgene: TXNDC16 H-InvDB: TXNDC16

    (According to HUGE)
    About This Section
    HUGE: KIAA1344

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TXNDC16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TXNDC16 gene:
    Search GeneIP for patents involving TXNDC16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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