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Aliases for TXNDC16 Gene

Aliases for TXNDC16 Gene

  • Thioredoxin Domain Containing 16 2 3
  • KIAA1344 2 3 4
  • Thioredoxin Domain-Containing Protein 16 3
  • ERp90 3

External Ids for TXNDC16 Gene

Previous Symbols for TXNDC16 Gene

  • KIAA1344

Summaries for TXNDC16 Gene

GeneCards Summary for TXNDC16 Gene

TXNDC16 (Thioredoxin Domain Containing 16) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC16 Gene

Genomics for TXNDC16 Gene

Genomic Location for TXNDC16 Gene

Start:
52,430,590 bp from pter
End:
52,552,583 bp from pter
Size:
121,994 bases
Orientation:
Minus strand

Genomic View for TXNDC16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXNDC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC16 Gene

Regulatory Elements for TXNDC16 Gene

Proteins for TXNDC16 Gene

  • Protein details for TXNDC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2K2-TXD16_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 16
    Protein Accession:
    Q9P2K2
    Secondary Accessions:
    • A5PKW9
    • A7E260
    • A7MD07
    • B9EH67
    • Q9H9W7

    Protein attributes for TXNDC16 Gene

    Size:
    825 amino acids
    Molecular mass:
    93572 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14101.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TXNDC16 Gene

Proteomics data for TXNDC16 Gene at MOPED

Post-translational modifications for TXNDC16 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn460

Other Protein References for TXNDC16 Gene

No data available for DME Specific Peptides for TXNDC16 Gene

Domains for TXNDC16 Gene

Protein Domains for TXNDC16 Gene

UniProtKB/Swiss-Prot:

TXD16_HUMAN
Domain:
  • Contains 1 thioredoxin domain.:
    • Q9P2K2
genes like me logo Genes that share domains with TXNDC16: view

No data available for Gene Families for TXNDC16 Gene

Function for TXNDC16 Gene

Gene Ontology (GO) - Molecular Function for TXNDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21359175
genes like me logo Genes that share ontologies with TXNDC16: view

Phenotypes for TXNDC16 Gene

genes like me logo Genes that share phenotypes with TXNDC16: view

miRNA for TXNDC16 Gene

miRTarBase miRNAs that target TXNDC16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TXNDC16 Gene

Localization for TXNDC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC16 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXNDC16 Gene COMPARTMENTS Subcellular localization image for TXNDC16 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TXNDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen IDA 21359175
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with TXNDC16: view

Pathways for TXNDC16 Gene

SuperPathways for TXNDC16 Gene

No Data Available

Interacting Proteins for TXNDC16 Gene

Gene Ontology (GO) - Biological Process for TXNDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TXNDC16: view

No data available for Pathways by source for TXNDC16 Gene

Transcripts for TXNDC16 Gene

Unigene Clusters for TXNDC16 Gene

Thioredoxin domain containing 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC16 Gene

No ASD Table

Relevant External Links for TXNDC16 Gene

GeneLoc Exon Structure for
TXNDC16
ECgene alternative splicing isoforms for
TXNDC16

Expression for TXNDC16 Gene

mRNA expression in normal human tissues for TXNDC16 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXNDC16 Gene

SOURCE GeneReport for Unigene cluster for TXNDC16 Gene Hs.532609

genes like me logo Genes that share expressions with TXNDC16: view

Orthologs for TXNDC16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TXNDC16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNDC16 36
  • 99.19 (n)
  • 99.15 (a)
TXNDC16 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TXNDC16 36
  • 85.19 (n)
  • 77.91 (a)
TXNDC16 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TXNDC16 36
  • 89.81 (n)
  • 87.65 (a)
TXNDC16 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Txndc16 36
  • 80.73 (n)
  • 76.16 (a)
Txndc16 16
Txndc16 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TXNDC16 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TXNDC16 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Txndc16 36
  • 77.96 (n)
  • 72.17 (a)
chicken
(Gallus gallus)
Aves TXNDC16 36
  • 63.76 (n)
  • 57.77 (a)
TXNDC16 37
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TXNDC16 37
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc16 36
  • 57.8 (n)
  • 47.19 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC556973 36
  • 50.77 (n)
  • 40.08 (a)
txndc16 37
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6226 37
  • 18 (a)
OneToOne
Species with no ortholog for TXNDC16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC16 Gene

ENSEMBL:
Gene Tree for TXNDC16 (if available)
TreeFam:
Gene Tree for TXNDC16 (if available)

Paralogs for TXNDC16 Gene

No data available for Paralogs for TXNDC16 Gene

Variants for TXNDC16 Gene

Sequence variations from dbSNP and Humsavar for TXNDC16 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11039 -- 52,430,901(-) TGCAT(A/C)TATTT utr-variant-3-prime
rs15755 -- 52,431,022(+) AAAAA(A/G)AAAAA utr-variant-3-prime
rs708540 -- 52,437,519(+) cccca(C/T)aagca intron-variant
rs716558 -- 52,486,037(+) ATTCC(A/G)TGACA intron-variant
rs729931 -- 52,521,867(+) tctga(C/G)agact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC16 Gene

Variant ID Type Subtype PubMed ID
nsv901951 CNV Gain 21882294
nsv826954 CNV Loss 20364138
esv2664522 CNV Deletion 23128226
esv2622229 CNV Loss 19546169
esv1464286 CNV Insertion 17803354
esv1116149 CNV Insertion 17803354

Relevant External Links for TXNDC16 Gene

HapMap Linkage Disequilibrium report
TXNDC16

Disorders for TXNDC16 Gene

(1) University of Copenhagen DISEASES for TXNDC16 Gene

Relevant External Links for TXNDC16

Genetic Association Database (GAD)
TXNDC16
genes like me logo Genes that share disorders with TXNDC16: view

No data available for UniProtKB/Swiss-Prot for TXNDC16 Gene

Publications for TXNDC16 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. (PMID: 22419666) Shi M. … Beaty T.H. (Am. J. Med. Genet. A 2012) 3 49
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3

Products for TXNDC16 Gene

Sources for TXNDC16 Gene

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