TXNDC16 Gene
protein-coding GIFtS: 44
GCID: GC14M052897
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thioredoxin domain containing 16(Previous name: KIAA1344 )
(Previous symbol: KIAA1344)
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Aliases
for TXNDC16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thioredoxin Domain Containing 161 2 | | KIAA13441 2 3 | | ERp902 | | Thioredoxin Domain-Containing Protein 162 |
Export aliases for TXNDC16 gene to outside databasesPrevious GC identifers: GC14M051968 GC14M033057 |
Summaries
for TXNDC16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TXNDC16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TXNDC16 gene promoter:
Oct-B1 oct-B2 NF-AT MZF-1 NF-AT4 NF-AT2 NRF-2 FOXO4 NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TXNDC16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q22.1 Ensembl cytogenetic band: 14q22.1 HGNC cytogenetic band: 14q22.1TXNDC16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M052897: view genomic region
(about GC identifiers)
Start:
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52,897,308 bp from pter |
End:
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53,019,301 bp from pter |
Size:
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121,994 bases |
Orientation:
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minus strand |
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Proteins
for TXNDC16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TXD16_HUMAN, Q9P2K2 (See
protein sequence)Recommended Name: Thioredoxin domain-containing protein 16 precursor Size: 825 amino acids; 93572 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=BAB14101.1; Type=Erroneous initiation;
Secondary accessions: A5PKW9 A7E260 A7MD07 B9EH67 Q9H9W7Explore the universe of human proteins at neXtProt for TXNDC16: NX_Q9P2K2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P2K2
TXNDC16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001153519.1 NP_065835.2
ENSEMBL proteins: ENSP00000281741 ENSP00000451619 ENSP00000450839
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
TXNDC16 for ontologies About GeneDecksing
TXNDC16 Antibody Products:
Assay Products for TXNDC16: |
Protein
Domains /
Families
for TXNDC16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TXNDC16 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P2K2ProtoNet protein and cluster: Q9P2K2 1 Blocks protein family: IPB006662 Thioredoxin type domain
UniProtKB/Swiss-Prot: TXD16_HUMAN, Q9P2K2Similarity: Contains 1 thioredoxin domain |
Function
for TXNDC16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC16 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TXNDC16 (NM_020784) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TXNDC16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC16 |
1 GenomeRNAi human phenotype for TXNDC16:
|
Pathways & Interactions
for TXNDC16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TXNDC16
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045454 | cell redox homeostasis |
IEA | -- |
TXNDC16 for ontologies About GeneDecksing
|
Drugs & Compounds
for TXNDC16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TXNDC16
Search CenterWatch for drugs/clinical trials and news about TXNDC16 / TXD16
|
Transcripts
for TXNDC16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TXNDC16 gene (2 alternative transcripts): NM_001160047.1 NM_020784.2 Unigene Cluster for TXNDC16: Thioredoxin domain containing 16 Hs.532609 [show with all ESTs]Unigene Representative Sequence: NM_0207844 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000281741(uc010tqu.2 uc001wzs.3 uc010aoe.3) ENST00000554399
ENST00000555312 ENST00000557374
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC16 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TXNDC16 (NM_020784) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TXNDC16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC16 |
Additional cDNA sequence: AB037765.2 AK022563.1 AK097748.1 BC137081.1 BC137082.1 BC142650.1 BC144469.1 BC150205.1 BC152428.1 4 DOTS entries: DT.111618 DT.100747810 DT.423127 DT.100660440 24/57 AceView cDNA sequences (see all 57): AK022563 AI832055 AI333000 AA347473 AA278675 AV646118 AL040840 AU124110 AA773166 AA909703 BU616802 AA903817 BM552780 AB037765 AA724711 BM728814 BU195149 BI712755 BV169005 H85222 AA609723 AA278257 AA934775 AI140821
GeneLoc Exon Structure
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Expression
for TXNDC16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TXNDC16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTGCTTA
About this image
See TXNDC16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TXNDC16
SOURCE GeneReport for Unigene cluster: Hs.532609
SABiosciences Custom PCR Arrays for TXNDC16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXNDC16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXNDC16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC16 |
Orthologs
for TXNDC16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TXNDC16 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for TXNDC16 (if available)
TreeFam Gene Tree for TXNDC16 (if available) |
Paralogs
for TXNDC16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TXNDC16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TXNDC16 (52897308 - 53019301 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TXNDC16
1 CNV: 101954 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TXNDC16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TXNDC16 for disorders About GeneDecksing
2  diseases for TXNDC16: About MalaCardsanaplastic meningioma meningioma
1 disease from the University of Copenhagen DISEASES database for TXNDC16:Meningioma Export disorders for TXNDC16 gene to outside databases
|
Publications
for TXNDC16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TXNDC16 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TXNDC16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- Genome wide study of maternal and parent-of-origin eff ects on the etiology of orofacial clefts. (PubMed id 22419666)1 Shi M....Beaty T.H. (2012)
- Identification of the PDI-family member ERp90 as an in teraction partner of ERFAD. (PubMed id 21359175)1 Riemer J....Ellgaard L. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)2 Nakajima D.... Nagase T. (2002)
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External Searches for TXNDC16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TXNDC16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TXNDC16 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TXNDC16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TXNDC16 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TXNDC16 gene:
Search GeneIP for patents involving TXNDC16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TXNDC16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TXNDC16 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TXNDC16 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXNDC16 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TXNDC16 | | OriGene 3'-UTR Clone for TXNDC16 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC16 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXNDC16 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TXNDC16 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TXNDC16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNDC16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC16 |
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| | | | Search Tocris compounds for TXNDC16 |
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 | | | TXNDC16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC16 |
|  |  |  | | | | Search ThermoFisher Antibodies for TXNDC16 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC16 |
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