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Aliases for TXNDC16 Gene

Aliases for TXNDC16 Gene

  • Thioredoxin Domain Containing 16 2 3 5
  • KIAA1344 2 3 4
  • ERp90 3

External Ids for TXNDC16 Gene

Previous HGNC Symbols for TXNDC16 Gene

  • KIAA1344

Previous GeneCards Identifiers for TXNDC16 Gene

  • GC14M051968
  • GC14M052897
  • GC14M033057

Summaries for TXNDC16 Gene

GeneCards Summary for TXNDC16 Gene

TXNDC16 (Thioredoxin Domain Containing 16) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC16 Gene

Genomics for TXNDC16 Gene

Regulatory Elements for TXNDC16 Gene

Enhancers for TXNDC16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TXNDC16 on UCSC Golden Path with GeneCards custom track

Genomic Location for TXNDC16 Gene

52,430,590 bp from pter
52,552,583 bp from pter
121,994 bases
Minus strand

Genomic View for TXNDC16 Gene

Genes around TXNDC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC16 Gene

Proteins for TXNDC16 Gene

  • Protein details for TXNDC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 16
    Protein Accession:
    Secondary Accessions:
    • A5PKW9
    • A7E260
    • A7MD07
    • B9EH67
    • Q9H9W7

    Protein attributes for TXNDC16 Gene

    825 amino acids
    Molecular mass:
    93572 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14101.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TXNDC16 Gene

Proteomics data for TXNDC16 Gene at MOPED

Post-translational modifications for TXNDC16 Gene

  • Glycosylation at Asn 460
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNDC16 Gene

No data available for DME Specific Peptides for TXNDC16 Gene

Domains & Families for TXNDC16 Gene

Protein Domains for TXNDC16 Gene

Suggested Antigen Peptide Sequences for TXNDC16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Contains 1 thioredoxin domain.
genes like me logo Genes that share domains with TXNDC16: view

No data available for Gene Families for TXNDC16 Gene

Function for TXNDC16 Gene

genes like me logo Genes that share phenotypes with TXNDC16: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TXNDC16

CRISPR Products

miRNA for TXNDC16 Gene

miRTarBase miRNAs that target TXNDC16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNDC16 Gene

Localization for TXNDC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC16 Gene


Subcellular locations from

Jensen Localization Image for TXNDC16 Gene COMPARTMENTS Subcellular localization image for TXNDC16 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
cytosol 2
mitochondrion 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TXNDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen IDA 21359175
genes like me logo Genes that share ontologies with TXNDC16: view

Pathways & Interactions for TXNDC16 Gene

SuperPathways for TXNDC16 Gene

No Data Available

Interacting Proteins for TXNDC16 Gene

Gene Ontology (GO) - Biological Process for TXNDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TXNDC16: view

No data available for Pathways by source and SIGNOR curated interactions for TXNDC16 Gene

Drugs & Compounds for TXNDC16 Gene

No Compound Related Data Available

Transcripts for TXNDC16 Gene

Unigene Clusters for TXNDC16 Gene

Thioredoxin domain containing 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC16 Gene

No ASD Table

Relevant External Links for TXNDC16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC16 Gene

mRNA expression in normal human tissues for TXNDC16 Gene

Protein differential expression in normal tissues from HIPED for TXNDC16 Gene

This gene is overexpressed in Urine (48.5) and Adipocyte (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXNDC16 Gene

SOURCE GeneReport for Unigene cluster for TXNDC16 Gene Hs.532609

genes like me logo Genes that share expression patterns with TXNDC16: view

Protein tissue co-expression partners for TXNDC16 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TXNDC16 Gene

Orthologs for TXNDC16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TXNDC16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TXNDC16 35
  • 85.19 (n)
  • 77.91 (a)
TXNDC16 36
  • 77 (a)
(Canis familiaris)
Mammalia TXNDC16 35
  • 89.81 (n)
  • 87.65 (a)
TXNDC16 36
  • 87 (a)
(Mus musculus)
Mammalia Txndc16 35
  • 80.73 (n)
  • 76.16 (a)
Txndc16 16
Txndc16 36
  • 76 (a)
(Pan troglodytes)
Mammalia TXNDC16 35
  • 99.19 (n)
  • 99.15 (a)
TXNDC16 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Txndc16 35
  • 77.96 (n)
  • 72.17 (a)
(Monodelphis domestica)
Mammalia TXNDC16 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TXNDC16 36
  • 65 (a)
(Gallus gallus)
Aves TXNDC16 35
  • 63.76 (n)
  • 57.77 (a)
TXNDC16 36
  • 53 (a)
(Anolis carolinensis)
Reptilia TXNDC16 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc16 35
  • 57.8 (n)
  • 47.19 (a)
(Danio rerio)
Actinopterygii LOC556973 35
  • 50.77 (n)
  • 40.08 (a)
txndc16 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6226 36
  • 18 (a)
Species with no ortholog for TXNDC16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC16 Gene

Gene Tree for TXNDC16 (if available)
Gene Tree for TXNDC16 (if available)

Paralogs for TXNDC16 Gene

No data available for Paralogs for TXNDC16 Gene

Variants for TXNDC16 Gene

Sequence variations from dbSNP and Humsavar for TXNDC16 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7155490 - 52,470,537(+) ATCTT(A/C/T)GGTTC nc-transcript-variant, reference, missense
rs28759013 - 52,519,279(+) CTTCA(C/T)TAAAA nc-transcript-variant, reference, missense, splice-acceptor-variant
rs28593180 - 52,519,232(+) AGCAT(A/C/T)TTCTA nc-transcript-variant, reference, missense
rs1350424 -- 52,535,059(-) TCCTG(A/G)AGTGG intron-variant
rs1379734 -- 52,535,057(-) CTGGA(A/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC16 Gene

Variant ID Type Subtype PubMed ID
nsv901951 CNV Gain 21882294
nsv826954 CNV Loss 20364138
esv2664522 CNV Deletion 23128226
esv2622229 CNV Loss 19546169
esv1464286 CNV Insertion 17803354
esv1116149 CNV Insertion 17803354

Variation tolerance for TXNDC16 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.15; 87.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TXNDC16 Gene

Disorders for TXNDC16 Gene

Relevant External Links for TXNDC16

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TXNDC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC16 Gene

Publications for TXNDC16 Gene

  1. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. (PMID: 22419666) Shi M. … Beaty T.H. (Am. J. Med. Genet. A 2012) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. (PMID: 24556642) Zeng Z. … Shaffer J.R. (Caries Res. 2014) 3

Products for TXNDC16 Gene

Sources for TXNDC16 Gene