Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TXNDC16 Gene

Aliases for TXNDC16 Gene

  • Thioredoxin Domain Containing 16 2 3 5
  • KIAA1344 2 3 4
  • ERp90 3 4
  • Thioredoxin Domain-Containing Protein 16 3

External Ids for TXNDC16 Gene

Previous HGNC Symbols for TXNDC16 Gene

  • KIAA1344

Previous GeneCards Identifiers for TXNDC16 Gene

  • GC14M051968
  • GC14M052897
  • GC14M033057

Summaries for TXNDC16 Gene

GeneCards Summary for TXNDC16 Gene

TXNDC16 (Thioredoxin Domain Containing 16) is a Protein Coding gene. Diseases associated with TXNDC16 include Meningioma, Familial.

Additional gene information for TXNDC16 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC16 Gene

Genomics for TXNDC16 Gene

Regulatory Elements for TXNDC16 Gene

Enhancers for TXNDC16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H052457 1.3 Ensembl ENCODE 11.5 +94.3 94258 2.1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 ATF7 FOS TSHZ1 REST TXNDC16 PTGER2 ERO1A GC14M052143
GH14H052324 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +226.0 226003 5 TBL1XR1 BACH1 BATF RELA ZNF316 EED FOS ATF7 ETV6 RUNX3 PTGER2 GNG2 TXNDC16 GC14P052338
GH14H052904 1.1 Ensembl ENCODE dbSUPER 6.9 -354.4 -354358 5 JUN EP300 BRCA1 ZKSCAN1 JUND POLR2A ZNF585B FOS CHD2 TCF7L2 TXNDC16 STYX LOC101927620 GC14P052872 FERMT2
GH14H052311 1.5 FANTOM5 ENCODE dbSUPER 4.9 +237.1 237122 8.7 PKNOX1 INSM2 SIN3A BMI1 BATF ZNF2 GLIS2 EGR1 ZNF366 RUNX3 PTGER2 GNG2 TXNDC16 RTRAF GC14P052338
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TXNDC16 on UCSC Golden Path with GeneCards custom track

Promoters for TXNDC16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000068444 -217 2801 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 FOS SP3

Genomic Locations for TXNDC16 Gene

Genomic Locations for TXNDC16 Gene
121,994 bases
Minus strand

Genomic View for TXNDC16 Gene

Genes around TXNDC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC16 Gene

Proteins for TXNDC16 Gene

  • Protein details for TXNDC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 16
    Protein Accession:
    Secondary Accessions:
    • A5PKW9
    • A7E260
    • A7MD07
    • B9EH67
    • Q9H9W7

    Protein attributes for TXNDC16 Gene

    825 amino acids
    Molecular mass:
    93572 Da
    Quaternary structure:
    • Interacts with FOXRED2.
    • Sequence=BAB14101.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TXNDC16 Gene

Post-translational modifications for TXNDC16 Gene

Other Protein References for TXNDC16 Gene

No data available for DME Specific Peptides for TXNDC16 Gene

Domains & Families for TXNDC16 Gene

Gene Families for TXNDC16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TXNDC16 Gene

Suggested Antigen Peptide Sequences for TXNDC16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains a masked and non-functional KDEL endoplasmic reticulum retrieval motif.
  • Contains a masked and non-functional KDEL endoplasmic reticulum retrieval motif.
genes like me logo Genes that share domains with TXNDC16: view

Function for TXNDC16 Gene

Phenotypes From GWAS Catalog for TXNDC16 Gene

Gene Ontology (GO) - Molecular Function for TXNDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21359175
genes like me logo Genes that share ontologies with TXNDC16: view
genes like me logo Genes that share phenotypes with TXNDC16: view

Animal Model Products

CRISPR Products

miRNA for TXNDC16 Gene

miRTarBase miRNAs that target TXNDC16

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNDC16 Gene

Localization for TXNDC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC16 Gene

Secreted. Endoplasmic reticulum lumen.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNDC16 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 2
mitochondrion 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TXNDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005623 cell IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IDA,IEA 21359175
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with TXNDC16: view

Pathways & Interactions for TXNDC16 Gene

SuperPathways for TXNDC16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TXNDC16: view

No data available for Pathways by source and SIGNOR curated interactions for TXNDC16 Gene

Drugs & Compounds for TXNDC16 Gene

No Compound Related Data Available

Transcripts for TXNDC16 Gene

Unigene Clusters for TXNDC16 Gene

Thioredoxin domain containing 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC16 Gene

No ASD Table

Relevant External Links for TXNDC16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNDC16 Gene

Protein differential expression in normal tissues from HIPED for TXNDC16 Gene

This gene is overexpressed in Urine (48.5) and Adipocyte (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXNDC16 Gene

Protein tissue co-expression partners for TXNDC16 Gene

NURSA nuclear receptor signaling pathways regulating expression of TXNDC16 Gene:


SOURCE GeneReport for Unigene cluster for TXNDC16 Gene:


Evidence on tissue expression from TISSUES for TXNDC16 Gene

  • Lung(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TXNDC16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNDC16 Gene

Orthologs for TXNDC16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TXNDC16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TXNDC16 33 34
  • 99.19 (n)
(Canis familiaris)
Mammalia TXNDC16 33 34
  • 89.81 (n)
(Bos Taurus)
Mammalia TXNDC16 33 34
  • 85.19 (n)
(Mus musculus)
Mammalia Txndc16 33 16 34
  • 80.73 (n)
(Rattus norvegicus)
Mammalia Txndc16 33
  • 77.96 (n)
(Monodelphis domestica)
Mammalia TXNDC16 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TXNDC16 34
  • 65 (a)
(Gallus gallus)
Aves TXNDC16 33 34
  • 63.76 (n)
(Anolis carolinensis)
Reptilia TXNDC16 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc16 33
  • 57.8 (n)
(Danio rerio)
Actinopterygii LOC556973 33
  • 50.77 (n)
txndc16 34
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6226 34
  • 18 (a)
Species where no ortholog for TXNDC16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC16 Gene

Gene Tree for TXNDC16 (if available)
Gene Tree for TXNDC16 (if available)

Paralogs for TXNDC16 Gene

No data available for Paralogs for TXNDC16 Gene

Variants for TXNDC16 Gene

Sequence variations from dbSNP and Humsavar for TXNDC16 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000012538 -- 52,458,013(+) AAAAC(A/G)CTCAT intron-variant
rs1000053779 -- 52,510,513(+) ACACA(A/T)CCATA intron-variant
rs1000058716 -- 52,492,742(+) ACTTA(A/C)CAGTC intron-variant
rs1000063079 -- 52,465,449(+) CAGCC(A/C/G)GGCTT intron-variant
rs1000076652 -- 52,435,721(+) TTTGG(A/C/G)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC16 Gene

Variant ID Type Subtype PubMed ID
nsv826954 CNV loss 20364138
nsv1051620 CNV loss 25217958
esv3634523 CNV loss 21293372
esv2664522 CNV deletion 23128226
esv2622229 CNV loss 19546169
esv1464286 CNV insertion 17803354
esv1116149 CNV insertion 17803354

Variation tolerance for TXNDC16 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.15; 87.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNDC16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC16 Gene

Disorders for TXNDC16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TXNDC16 Gene - From: DISEASES

Disorder Aliases PubMed IDs
meningioma, familial
  • meningioma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TXNDC16

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TXNDC16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXNDC16 Gene

Publications for TXNDC16 Gene

  1. Secretion and immunogenicity of the meningioma-associated antigen TXNDC16. (PMID: 25122923) Harz C … Meese E (Journal of immunology (Baltimore, Md. : 1950) 2014) 3 4 60
  2. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. (PMID: 22419666) Shi M … Beaty TH (American journal of medical genetics. Part A 2012) 3 45 60
  3. Identification of the PDI-family member ERp90 as an interaction partner of ERFAD. (PMID: 21359175) Riemer J … Ellgaard L (PloS one 2011) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 60

Products for TXNDC16 Gene

Sources for TXNDC16 Gene

Loading form....