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TXNDC15 Gene

protein-coding   GIFtS: 45
GCID: GC05P134211

Thioredoxin Domain Containing 15

(Previous name: chromosome 5 open reading frame 14)
(Previous symbol: C5orf14)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin Domain Containing 151 2     UNQ3352
C5orf141 2 3     Disulfide Isomerase2
Chromosome 5 Open Reading Frame 141     Thioredoxin Domain-Containing Protein 152
2310047H23Rik2     

External Ids:    HGNC: 206521   Entrez Gene: 797702   Ensembl: ENSG000001136217   UniProtKB: Q96J423   

Export aliases for TXNDC15 gene to outside databases

Previous GC identifers: GC05P134238 GC05P129395


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TXNDC15 Gene:
TXNDC15 (thioredoxin domain containing 15) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TXNDC15 gene promoter:
         p53   Nkx2-5   FOXL1   HNF-1A   Evi-1   E47   c-Rel   HNF-1   Hand1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TXNDC15 promoter sequence
   Search Chromatin IP Primers for TXNDC15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXNDC15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

TXNDC15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNDC15 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P134211:  view genomic region     (about GC identifiers)

Start:
134,209,460 bp from pter      End:
134,237,323 bp from pter
Size:
27,864 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TXD15_HUMAN, Q96J42 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 15 precursor  
Size: 360 amino acids; 39885 Da
Caution: It is uncertain whether Met-1 or Met-13 is the initiator
Secondary accessions: D3DQA9 Q96MT2 Q9H639
Alternative splicing: 2 isoforms:  Q96J42-1   Q96J42-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TXNDC15: NX_Q96J42

Explore proteomics data for TXNDC15 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys272
  • Glycosylation2 at Asn187, Asn194, Asn206, Asn293
  • Modification sites at PhosphoSitePlus

  • See TXNDC15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078991.3  
    ENSEMBL proteins: 
     ENSP00000351157   ENSP00000423609   ENSP00000424220   ENSP00000424716   ENSP00000424428  
     ENSP00000423513   ENSP00000422832   ENSP00000443942  

    TXNDC15 Human Recombinant Protein Products:

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    Novus Biologicals TXNDC15 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TXNDC15

     
    Search eBioscience for Proteins for TXNDC15 

     
    antibodies-online proteins for TXNDC15 (6 products) 

     
    antibodies-online peptides for TXNDC15

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    antibodies-online antibodies for TXNDC15 (11 products) 

    TXNDC15 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TXNDC15
    Cloud-Clone Corp. CLIAs for TXNDC15
    Search eBioscience for ELISAs for TXNDC15 
    antibodies-online kits for TXNDC15 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR013766 Thioredoxin_domain

    Graphical View of Domain Structure for InterPro Entry Q96J42

    ProtoNet protein and cluster: Q96J42

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TXD15_HUMAN, Q96J42
    Similarity: Contains 1 thioredoxin domain


    Find genes that share domains with TXNDC15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for TXNDC15:
     Decreased Wnt reporter activit  Increased homologous recombina 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TXNDC15

    miRNA
    Products:
        
    miRTarBase miRNAs that target TXNDC15:
    hsa-mir-18a-5p (MIRT050736)

    Block miRNA regulation of human, mouse, rat TXNDC15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TXNDC15 (see all 40):
    hsa-miR-21* hsa-miR-548j hsa-miR-507 hsa-miR-629* hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-23a hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidTXNDC15 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TXNDC15
    Predesigned siRNA for gene silencing in human, mouse, rat TXNDC15

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TXNDC15

    Clone
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    OriGene ORF clones in mouse, rat for TXNDC15
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    GenScript: all cDNA clones in your preferred vector: TXNDC15 (NM_024715)
    Sino Biological Human cDNA Clone for TXNDC15
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNDC15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC15

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TXD15_HUMAN, Q96J42: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TXNDC15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TXNDC15
    Interactions:

        GeneGlobe Interaction Network for TXNDC15

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045454cell redox homeostasis IEA--

    Find genes that share ontologies with TXNDC15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TXNDC15 (TXD15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TXNDC15 gene: 
    NM_024715.3  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358387(uc010jdy.1 uc003lac.1) ENST00000511070 ENST00000506916
    ENST00000507024 ENST00000508810 ENST00000508779 ENST00000506350 ENST00000505174
    ENST00000509954 ENST00000502625 ENST00000546290
    miRNA
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    Block miRNA regulation of human, mouse, rat TXNDC15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TXNDC15 (see all 40):
    hsa-miR-21* hsa-miR-548j hsa-miR-507 hsa-miR-629* hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-23a hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidTXNDC15 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TXNDC15
    Predesigned siRNA for gene silencing in human, mouse, rat TXNDC15
    Clone
    Products:
         
    OriGene clones in human, mouse for TXNDC15 (see all 7)
    OriGene ORF clones in mouse, rat for TXNDC15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TXNDC15 (NM_024715)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNDC15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC15
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TXNDC15
    OriGene qSTAR qPCR primer pairs in human, mouse for TXNDC15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TXNDC15
      QuantiTect SYBR Green Assays in human, mouse, rat TXNDC15
      QuantiFast Probe-based Assays in human, mouse, rat TXNDC15

    Selected AceView cDNA sequences (see all 234):

    W47023 BE673389 BC001615 AA878057 BQ018069 CR616649 BX506265 CD358906 
    AW513555 BQ287952 BM686598 AA863179 AA737338 BQ679976 BI714778 AI568784 
    AA931722 AA047692 BQ682436 BQ447928 AA490379 AI269156 BU618710 CR613370 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC15 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                          -     -                             -                                                         
    SP2:                                                                                                                        
    SP3:                                                                                                  -     -               
    SP4:                          -     -                                                                                       
    SP5:                    -     -     -                                                                                       


    ECgene alternative splicing isoforms for TXNDC15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TXNDC15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTACTTA
    TXNDC15 Expression
    About this image

    TXNDC15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TXNDC15 Protein Expression
        Custom PCR Arrays for TXNDC15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TXNDC15 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txndc151 , 5 thioredoxin domain containing 151, 5 79.94(n)1
    80.81(a)1
      13 (30.06 cM)5
    696721  NM_175150.31  NP_780359.21 
     557146505 
    chicken
    (Gallus gallus)
    Aves TXNDC151 thioredoxin domain containing 15 63.58(n)
    64.51(a)
      416310  XM_414627.4  XP_414627.3 
    lizard
    (Anolis carolinensis)
    Reptilia TXNDC156
    thioredoxin domain containing 15
    82(a)
    1 ↔ 1
    GL343223.1(332481-343554)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.124922 Xenopus laevis transcribed sequence with moderate similarity more 74.2(n)    BJ063597.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.167732 Transcribed sequence with weak similarity to protein more 73.12(n)    BI982413.1 


    ENSEMBL Gene Tree for TXNDC15 (if available)
    TreeFam Gene Tree for TXNDC15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TXNDC15 gene
    1 SIMAP similar gene for TXNDC15 using alignment to 8 protein entries:     TXD15_HUMAN (see all proteins):
    DKFZp686L0872

    Find genes that share paralogs with TXNDC15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TXNDC15 (see all 509)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361724
    A breast cancer sample4--see VAR_0361722 S P mis40--------
    rs1897832071,2
    --134207489(+) GATGTC/TCCAGA 1 -- us2k10--------
    rs1811078971,2
    --134207535(+) TTGGCA/GGATTT 1 -- us2k10--------
    rs1861391761,2
    --134207652(+) TGCACA/GTTGGT 1 -- us2k10--------
    rs737907191,2
    C,F--134207741(+) AAAGAC/TGCTCA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1475866621,2
    --134207790(+) GGACTA/GCTTGA 1 -- us2k10--------
    rs1889464321,2
    --134207872(+) TGGGAA/CGATCG 1 -- us2k10--------
    rs763115951,2
    C--134207944(+) GCGAGA/GCTGTG 1 -- us2k10--------
    rs104912951,2
    C,F,H--134208028(+) TATCTG/TTCCCA 1 -- us2k1102Minor allele frequency- T:0.17NS EA NA PA EU CA WA 6220
    rs1159558631,2
    F--134208069(+) GGGCCG/AGGCGC 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for TXNDC15 (134209460 - 134237323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TXNDC15:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674924CNV Deletion23128226
    nsv830493CNV Loss17160897
    nsv830494CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TXNDC15
    DNA2.0 Custom Variant and Variant Library Synthesis for TXNDC15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TXNDC15           About GenesLikeMe

    Genetic Association Database (GAD): TXNDC15

    Export disorders for TXNDC15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TXNDC15 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TXNDC15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. Cell surface thiol isomerases may explain the platelet-selective action of S-nitrosoglutathione. (PubMed id 21642008)1 Xiao F. and Gordge M.P. (Nitric Oxide 2011)
    7. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)
    8. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79770 HGNC: 20652 AceView: C5orf14 Ensembl:ENSG00000113621 euGenes: HUgn79770
    ECgene: TXNDC15 H-InvDB: TXNDC15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TXNDC15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TXNDC15 gene:
    Search GeneIP for patents involving TXNDC15

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