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Aliases for TXNDC15 Gene

Aliases for TXNDC15 Gene

  • Thioredoxin Domain Containing 15 2 3 5
  • C5orf14 3 4
  • Thioredoxin Domain-Containing Protein 15 3
  • Chromosome 5 Open Reading Frame 14 2
  • Disulfide Isomerase 3
  • 2310047H23Rik 3
  • UNQ335 3

External Ids for TXNDC15 Gene

Previous HGNC Symbols for TXNDC15 Gene

  • C5orf14

Previous GeneCards Identifiers for TXNDC15 Gene

  • GC05P134238
  • GC05P129395
  • GC05P134211

Summaries for TXNDC15 Gene

GeneCards Summary for TXNDC15 Gene

TXNDC15 (Thioredoxin Domain Containing 15) is a Protein Coding gene. Diseases associated with TXNDC15 include Meckel Syndrome 1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC15 Gene

Genomics for TXNDC15 Gene

Regulatory Elements for TXNDC15 Gene

Enhancers for TXNDC15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F134912 0.2 ENCODE 16.3 +40.0 39951 1.7 ATF1 ARNT ZNF766 GATA2 NCOA1 SREBF1 SMARCA4 PBX2 HMBOX1 NBN ENSG00000270892 TXNDC15 LOC105379188 ENSG00000248753 ENSG00000271128 NEUROG1 ENSG00000279799 MTCYBP18
GH05F134646 0.4 ENCODE 14.2 -224.8 -224755 4.4 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 TXNDC15 SAR1B GC05M134647
GH05F134590 0.6 Ensembl ENCODE 12.6 -281.7 -281732 2.7 HDGF PKNOX1 ATF1 WRNIP1 ARID4B SIN3A RFX5 SCRT2 ETV6 FOS TXNDC15 RNU6-1311P SAR1B ENSG00000248559 DDX46 GC05M134578 GC05M134635
GH05F134586 1.2 Ensembl ENCODE 12.6 -286.6 -286575 1.6 CTCF CBX3 INSM2 ARID4B ZNF384 ZIC2 RAD21 HBP1 ZNF23 GLIS2 TXNDC15 ENSG00000248559 GC05M134578 GC05M134635 RNU6-1311P
GH05F134849 0.5 ENCODE 12.4 -23.9 -23940 0.1 ZNF121 ZNF362 ZNF384 TXNDC15 C5orf24 GC05M134654
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TXNDC15 on UCSC Golden Path with GeneCards custom track

Promoters for TXNDC15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001290643 1030 2001 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS

Genomic Location for TXNDC15 Gene

Chromosome:
5
Start:
134,873,770 bp from pter
End:
134,901,633 bp from pter
Size:
27,864 bases
Orientation:
Plus strand

Genomic View for TXNDC15 Gene

Genes around TXNDC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC15 Gene

Proteins for TXNDC15 Gene

  • Protein details for TXNDC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96J42-TXD15_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 15
    Protein Accession:
    Q96J42
    Secondary Accessions:
    • D3DQA9
    • Q96MT2
    • Q9H639

    Protein attributes for TXNDC15 Gene

    Size:
    360 amino acids
    Molecular mass:
    39885 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TXNDC15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TXNDC15 Gene

Post-translational modifications for TXNDC15 Gene

  • Ubiquitination at Lys 272
  • Glycosylation at Asn 187, Asn 194, Asn 206, and Asn 293
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNDC15 Gene

No data available for DME Specific Peptides for TXNDC15 Gene

Domains & Families for TXNDC15 Gene

Protein Domains for TXNDC15 Gene

Graphical View of Domain Structure for InterPro Entry

Q96J42

UniProtKB/Swiss-Prot:

TXD15_HUMAN :
  • Contains 1 thioredoxin domain.
Domain:
  • Contains 1 thioredoxin domain.
genes like me logo Genes that share domains with TXNDC15: view

No data available for Gene Families for TXNDC15 Gene

Function for TXNDC15 Gene

genes like me logo Genes that share phenotypes with TXNDC15: view

Animal Model Products

miRNA for TXNDC15 Gene

miRTarBase miRNAs that target TXNDC15

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNDC15 Gene

Localization for TXNDC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC15 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXNDC15 Gene COMPARTMENTS Subcellular localization image for TXNDC15 gene
Compartment Confidence
golgi apparatus 2
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TXNDC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TXNDC15: view

Pathways & Interactions for TXNDC15 Gene

SuperPathways for TXNDC15 Gene

No Data Available

Interacting Proteins for TXNDC15 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000351157%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000403397%0d%0a
Selected Interacting proteins: ENSP00000351157 Q96J42-TXD15_HUMAN for TXNDC15 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TXNDC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TXNDC15: view

No data available for Pathways by source and SIGNOR curated interactions for TXNDC15 Gene

Transcripts for TXNDC15 Gene

Unigene Clusters for TXNDC15 Gene

Thioredoxin domain containing 15:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC15 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - -
SP2:
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - - - - - - -
SP7: -
SP8:

Relevant External Links for TXNDC15 Gene

GeneLoc Exon Structure for
TXNDC15
ECgene alternative splicing isoforms for
TXNDC15

Expression for TXNDC15 Gene

mRNA expression in normal human tissues for TXNDC15 Gene

Protein differential expression in normal tissues from HIPED for TXNDC15 Gene

This gene is overexpressed in Breast (34.8), Heart (9.1), and Placenta (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TXNDC15 Gene



Protein tissue co-expression partners for TXNDC15 Gene

NURSA nuclear receptor signaling pathways regulating expression of TXNDC15 Gene:

TXNDC15

SOURCE GeneReport for Unigene cluster for TXNDC15 Gene:

Hs.741304
genes like me logo Genes that share expression patterns with TXNDC15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TXNDC15 Gene

Orthologs for TXNDC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TXNDC15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNDC15 34 35
  • 99.33 (n)
cow
(Bos Taurus)
Mammalia TXNDC15 34 35
  • 87.32 (n)
dog
(Canis familiaris)
Mammalia TXNDC15 34 35
  • 85.06 (n)
mouse
(Mus musculus)
Mammalia Txndc15 34 16 35
  • 79.94 (n)
rat
(Rattus norvegicus)
Mammalia Txndc15 34
  • 78.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TXNDC15 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TXNDC15 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TXNDC15 34 35
  • 63.58 (n)
lizard
(Anolis carolinensis)
Reptilia TXNDC15 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc15 34
  • 64.05 (n)
Str.7095 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12492 34
zebrafish
(Danio rerio)
Actinopterygii zgc:165608 34
  • 60.98 (n)
TXNDC15 35
  • 52 (a)
OneToOne
Dr.16773 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11182 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToOne
Species where no ortholog for TXNDC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC15 Gene

ENSEMBL:
Gene Tree for TXNDC15 (if available)
TreeFam:
Gene Tree for TXNDC15 (if available)

Paralogs for TXNDC15 Gene

(1) SIMAP similar genes for TXNDC15 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TXNDC15: view

No data available for Paralogs for TXNDC15 Gene

Variants for TXNDC15 Gene

Sequence variations from dbSNP and Humsavar for TXNDC15 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_036172 A breast cancer sample
rs10479086 -- 134,896,110(+) CCCCC(A/C)AGCCA intron-variant
rs10491295 -- 134,872,338(+) TATCT(G/T)TCCCA upstream-variant-2KB
rs10670765 -- 134,900,221(+) CTCTA(-/CTTTA)ACTCA utr-variant-3-prime
rs111349483 -- 134,879,055(+) CACAT(A/G)GTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC15 Gene

Variant ID Type Subtype PubMed ID
esv2674924 CNV deletion 23128226
esv3606852 CNV loss 21293372
nsv830493 CNV loss 17160897
nsv830494 CNV gain+loss 17160897

Variation tolerance for TXNDC15 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNDC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNDC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC15 Gene

Disorders for TXNDC15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TXNDC15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
meckel syndrome 1
  • meckel syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TXNDC15

Genetic Association Database (GAD)
TXNDC15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXNDC15
genes like me logo Genes that share disorders with TXNDC15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXNDC15 Gene

Publications for TXNDC15 Gene

  1. Characterizing the morbid genome of ciliopathies. (PMID: 27894351) Shaheen R. … Alkuraya F.S. (Genome Biol. 2016) 2 3 64
  2. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TXNDC15 Gene

Sources for TXNDC15 Gene

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