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Aliases for TXNDC15 Gene

Aliases for TXNDC15 Gene

  • Thioredoxin Domain Containing 15 2 3 5
  • C5orf14 3 4
  • Chromosome 5 Open Reading Frame 14 2
  • Disulfide Isomerase 3
  • 2310047H23Rik 3
  • UNQ335 3

External Ids for TXNDC15 Gene

Previous HGNC Symbols for TXNDC15 Gene

  • C5orf14

Previous GeneCards Identifiers for TXNDC15 Gene

  • GC05P134238
  • GC05P129395
  • GC05P134211

Summaries for TXNDC15 Gene

GeneCards Summary for TXNDC15 Gene

TXNDC15 (Thioredoxin Domain Containing 15) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC15 Gene

Genomics for TXNDC15 Gene

Regulatory Elements for TXNDC15 Gene

Promoters for TXNDC15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TXNDC15 on UCSC Golden Path with GeneCards custom track

Genomic Location for TXNDC15 Gene

134,873,770 bp from pter
134,901,633 bp from pter
27,864 bases
Plus strand

Genomic View for TXNDC15 Gene

Genes around TXNDC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC15 Gene

Proteins for TXNDC15 Gene

  • Protein details for TXNDC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 15
    Protein Accession:
    Secondary Accessions:
    • D3DQA9
    • Q96MT2
    • Q9H639

    Protein attributes for TXNDC15 Gene

    360 amino acids
    Molecular mass:
    39885 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TXNDC15 Gene


neXtProt entry for TXNDC15 Gene

Proteomics data for TXNDC15 Gene at MOPED

Post-translational modifications for TXNDC15 Gene

  • Ubiquitination at Lys 272
  • Glycosylation at Asn 187, Asn 194, Asn 206, and Asn 293
  • Modification sites at PhosphoSitePlus

Other Protein References for TXNDC15 Gene

No data available for DME Specific Peptides for TXNDC15 Gene

Domains & Families for TXNDC15 Gene

Protein Domains for TXNDC15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Contains 1 thioredoxin domain.
genes like me logo Genes that share domains with TXNDC15: view

No data available for Gene Families for TXNDC15 Gene

Function for TXNDC15 Gene

genes like me logo Genes that share phenotypes with TXNDC15: view

Animal Model Products

CRISPR Products

miRNA for TXNDC15 Gene

miRTarBase miRNAs that target TXNDC15

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNDC15 Gene

Localization for TXNDC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC15 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TXNDC15 Gene COMPARTMENTS Subcellular localization image for TXNDC15 gene
Compartment Confidence
golgi apparatus 2
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TXNDC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TXNDC15: view

Pathways & Interactions for TXNDC15 Gene

SuperPathways for TXNDC15 Gene

No Data Available

Interacting Proteins for TXNDC15 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000351157 for TXNDC15 Gene via STRING

Gene Ontology (GO) - Biological Process for TXNDC15 Gene


No data available for Pathways by source and SIGNOR curated interactions for TXNDC15 Gene

Drugs & Compounds for TXNDC15 Gene

No Compound Related Data Available

Transcripts for TXNDC15 Gene

Unigene Clusters for TXNDC15 Gene

Thioredoxin domain containing 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC15 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - - - - - - -
SP7: -

Relevant External Links for TXNDC15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC15 Gene

mRNA expression in normal human tissues for TXNDC15 Gene

Protein differential expression in normal tissues from HIPED for TXNDC15 Gene

This gene is overexpressed in Breast (34.8), Heart (9.1), and Placenta (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TXNDC15 Gene

SOURCE GeneReport for Unigene cluster for TXNDC15 Gene Hs.741304

genes like me logo Genes that share expression patterns with TXNDC15: view

Protein tissue co-expression partners for TXNDC15 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TXNDC15 Gene

Orthologs for TXNDC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TXNDC15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TXNDC15 35
  • 87.32 (n)
  • 86.48 (a)
TXNDC15 36
  • 85 (a)
(Canis familiaris)
Mammalia TXNDC15 35
  • 85.06 (n)
  • 86.78 (a)
TXNDC15 36
  • 87 (a)
(Mus musculus)
Mammalia Txndc15 35
  • 79.94 (n)
  • 80.81 (a)
Txndc15 16
Txndc15 36
  • 81 (a)
(Pan troglodytes)
Mammalia TXNDC15 35
  • 99.33 (n)
  • 99.43 (a)
TXNDC15 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Txndc15 35
  • 78.62 (n)
  • 80.17 (a)
(Monodelphis domestica)
Mammalia TXNDC15 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia TXNDC15 36
  • 74 (a)
(Gallus gallus)
Aves TXNDC15 35
  • 63.58 (n)
  • 64.51 (a)
TXNDC15 36
  • 59 (a)
(Anolis carolinensis)
Reptilia TXNDC15 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7095 35
txndc15 35
  • 64.05 (n)
  • 60.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12492 35
(Danio rerio)
Actinopterygii Dr.16773 35
zgc:165608 35
  • 60.98 (n)
  • 62.21 (a)
TXNDC15 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11182 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for TXNDC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC15 Gene

Gene Tree for TXNDC15 (if available)
Gene Tree for TXNDC15 (if available)

Paralogs for TXNDC15 Gene

(1) SIMAP similar genes for TXNDC15 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TXNDC15: view

No data available for Paralogs for TXNDC15 Gene

Variants for TXNDC15 Gene

Sequence variations from dbSNP and Humsavar for TXNDC15 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_036172 A breast cancer sample
rs319600 -- 134,899,923(-) TACGT(G/T)CATGC utr-variant-3-prime
rs319601 -- 134,887,477(-) GGGCA(C/T)GGTGG intron-variant
rs319602 -- 134,886,474(-) CCTCC(A/G)TAGCA intron-variant
rs2302358 -- 134,874,371(+) CCTTC(C/T)TCCGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TXNDC15 Gene

Variant ID Type Subtype PubMed ID
nsv830493 CNV Loss 17160897
nsv830494 CNV Gain+Loss 17160897
esv2674924 CNV Deletion 23128226

Variation tolerance for TXNDC15 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNDC15 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC15 Gene

Disorders for TXNDC15 Gene

Relevant External Links for TXNDC15

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TXNDC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC15 Gene

Publications for TXNDC15 Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3
  5. Cell surface thiol isomerases may explain the platelet-selective action of S-nitrosoglutathione. (PMID: 21642008) Xiao F. … Gordge M.P. (Nitric Oxide 2011) 3

Products for TXNDC15 Gene

Sources for TXNDC15 Gene

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