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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TXNDC15 Gene

protein-coding   GIFtS: 45
GCID: GC05P134211

Thioredoxin Domain Containing 15

(Previous name: chromosome 5 open reading frame 14)
(Previous symbol: C5orf14)
  Search for TXNDC15
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thioredoxin Domain Containing 151 2     UNQ3352
C5orf141 2 3     Disulfide Isomerase2
Chromosome 5 Open Reading Frame 141     Thioredoxin Domain-Containing Protein 152
2310047H23Rik2     

External Ids:    HGNC: 206521   Entrez Gene: 797702   Ensembl: ENSG000001136217   UniProtKB: Q96J423   

Export aliases for TXNDC15 gene to outside databases

Previous GC identifers: GC05P134238 GC05P129395


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TXNDC15 Gene: 
TXNDC15 (thioredoxin domain containing 15) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TXNDC15 gene promoter:
         p53   Nkx2-5   FOXL1   HNF-1A   Evi-1   E47   c-Rel   HNF-1   Hand1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TXNDC15 promoter sequence
   Search SABiosciences Chromatin IP Primers for TXNDC15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

TXNDC15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNDC15 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P134211:  view genomic region     (about GC identifiers)

Start:
134,209,460 bp from pter      End:
134,237,323 bp from pter
Size:
27,864 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TXD15_HUMAN, Q96J42 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 15 precursor  
Size: 360 amino acids; 39885 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Caution: It is uncertain whether Met-1 or Met-13 is the initiator
Secondary accessions: D3DQA9 Q96MT2 Q9H639
Alternative splicing: 2 isoforms:  Q96J42-1   Q96J42-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TXNDC15: NX_Q96J42

Explore proteomics data for TXNDC15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96J42

  • TXNDC15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TXNDC15 Protein Expression
    REFSEQ proteins: NP_078991.3  
    ENSEMBL proteins: 
     ENSP00000351157   ENSP00000423609   ENSP00000424220   ENSP00000424716   ENSP00000424428  
     ENSP00000423513   ENSP00000422832   ENSP00000443942  

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    Cloud-Clone Corp. Proteins for TXNDC15 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TXNDC15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR013766 Thioredoxin_domain
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q96J42

    ProtoNet protein and cluster: Q96J42

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TXD15_HUMAN, Q96J42
    Similarity: Contains 1 thioredoxin domain


    TXNDC15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for TXNDC15:
     Decreased Wnt reporter activit  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TXNDC15 
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    SwitchGear 3'UTR luciferase reporter plasmidTXNDC15 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TXNDC15

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045454cell redox homeostasis IEA--

    TXNDC15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TXNDC15 (TXD15)

    Search CenterWatch for drugs/clinical trials and news about TXNDC15 / TXD15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TXNDC15 gene: 
    NM_024715.3  

    Unigene Cluster for TXNDC15:

    Thioredoxin domain containing 15
    Hs.741304  [show with all ESTs]
    Unigene Representative Sequence: NM_024715
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358387(uc010jdy.1 uc003lac.1) ENST00000511070 ENST00000506916
    ENST00000507024 ENST00000508810 ENST00000508779 ENST00000506350 ENST00000505174
    ENST00000509954 ENST00000502625 ENST00000546290
    miRNA
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    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNDC15 (see all 40):
    hsa-miR-21* hsa-miR-548j hsa-miR-507 hsa-miR-629* hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-23a hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidTXNDC15 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC15

    Additional mRNA sequence: 

    AK026278.1 AK092425.1 AK225454.1 AK225462.1 AK299578.1 AK307529.1 AY358649.1 BC001615.1 
    BC032568.1 BX538131.1 

    13 DOTS entries:

    DT.446648  DT.100811828  DT.40132328  DT.100686768  DT.120854485  DT.100669627  DT.100811832  DT.120854478 
    DT.120854453  DT.40192978  DT.97796640  DT.97806613  DT.95307560 

    24/234 AceView cDNA sequences (see all 234):

    BQ416904 AK092425 AA878057 CB853223 AI625174 AW513555 AA757018 BU950077 
    BU163418 AI922610 AI202584 AI568784 BM673580 AI955245 AL710291 AI269156 
    W47023 BI715332 CD358906 BM932055 CR613338 AA490379 BQ678772 BM686598 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC15 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                          -     -                             -                                                         
    SP2:                                                                                                                        
    SP3:                                                                                                  -     -               
    SP4:                          -     -                                                                                       
    SP5:                    -     -     -                                                                                       


    ECgene alternative splicing isoforms for TXNDC15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TXNDC15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTACTTA
    TXNDC15 Expression
    About this image


    See TXNDC15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TXNDC15

    SOURCE GeneReport for Unigene cluster: Hs.741304
        SABiosciences Custom PCR Arrays for TXNDC15
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TXNDC15 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txndc151 , 5 thioredoxin domain containing 151, 5 79.94(n)1
    80.81(a)1
      13 (30.06 cM)5
    696721  NM_175150.31  NP_780359.21 
     557146505 
    chicken
    (Gallus gallus)
    Aves TXNDC151 thioredoxin domain containing 15 68.01(n)
    70.59(a)
      416310  XM_414627.3  XP_414627.2 
    lizard
    (Anolis carolinensis)
    Reptilia TXNDC156
    Uncharacterized protein
    81(a)
    1 ↔ 1
    GL343223.1(332481-343554)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.124922 Xenopus laevis transcribed sequence with moderate similarity more 74.2(n)    BJ063597.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.167732 Transcribed sequence with weak similarity to protein more 73.12(n)    BI982413.1 


    ENSEMBL Gene Tree for TXNDC15 (if available)
    TreeFam Gene Tree for TXNDC15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TXNDC15 gene
    1 SIMAP similar gene for TXNDC15 using alignment to 8 protein entries:     TXD15_HUMAN (see all proteins):
    DKFZp686L0872

    TXNDC15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/509 SNPs in TXNDC15 are shown (see all 509)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361724
    A breast cancer sample4--see VAR_0361722 S P mis40--------
    rs1897832071,2
    --134207489(+) GATGTC/TCCAGA 1 -- us2k10--------
    rs1811078971,2
    --134207535(+) TTGGCA/GGATTT 1 -- us2k10--------
    rs1861391761,2
    --134207652(+) TGCACA/GTTGGT 1 -- us2k10--------
    rs737907191,2
    C,F--134207741(+) AAAGAC/TGCTCA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1475866621,2
    --134207790(+) GGACTA/GCTTGA 1 -- us2k10--------
    rs1889464321,2
    --134207872(+) TGGGAA/CGATCG 1 -- us2k10--------
    rs763115951,2
    C--134207944(+) GCGAGA/GCTGTG 1 -- us2k10--------
    rs104912951,2
    C,F,H--134208028(+) TATCTG/TTCCCA 1 -- us2k1102Minor allele frequency- T:0.17NS EA NA PA EU CA WA 6220
    rs1159558631,2
    F--134208069(+) GGGCCG/AGGCGC 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for TXNDC15 (134209460 - 134237323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TXNDC15:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674924CNV Deletion23128226
    nsv830493CNV Loss17160897
    nsv830494CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TXNDC15 for disorders           About MalaCards

    TXNDC15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TXNDC15

    Export disorders for TXNDC15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TXNDC15 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TXNDC15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. Cell surface thiol isomerases may explain the platelet -selective action of S-nitrosoglutathione. (PubMed id 21642008)1 Xiao F. and Gordge M.P. (2011)
    6. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    7. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (2007)
    8. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1 Zhang H.... Aebersold R. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79770 HGNC: 20652 AceView: C5orf14 Ensembl:ENSG00000113621 euGenes: HUgn79770
    ECgene: TXNDC15 H-InvDB: TXNDC15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TXNDC15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TXNDC15 gene:
    Search GeneIP for patents involving TXNDC15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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