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Aliases for TXNDC15 Gene

Aliases for TXNDC15 Gene

  • Thioredoxin Domain Containing 15 2 3
  • C5orf14 3 4
  • Thioredoxin Domain-Containing Protein 15 3
  • Chromosome 5 Open Reading Frame 14 2
  • Disulfide Isomerase 3
  • 2310047H23Rik 3
  • UNQ335 3

External Ids for TXNDC15 Gene

Previous Symbols for TXNDC15 Gene

  • C5orf14

Summaries for TXNDC15 Gene

GeneCards Summary for TXNDC15 Gene

TXNDC15 (Thioredoxin Domain Containing 15) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC15 Gene

Genomics for TXNDC15 Gene

Genomic Location for TXNDC15 Gene

134,873,770 bp from pter
134,901,633 bp from pter
27,864 bases
Plus strand

Genomic View for TXNDC15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXNDC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC15 Gene

Regulatory Elements for TXNDC15 Gene

Proteins for TXNDC15 Gene

  • Protein details for TXNDC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 15
    Protein Accession:
    Secondary Accessions:
    • D3DQA9
    • Q96MT2
    • Q9H639

    Protein attributes for TXNDC15 Gene

    360 amino acids
    Molecular mass:
    39885 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TXNDC15 Gene


neXtProt entry for TXNDC15 Gene

Proteomics data for TXNDC15 Gene at MOPED

Post-translational modifications for TXNDC15 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys272
  • Glycosylation at Asn187, Asn194, Asn206, and Asn293

Other Protein References for TXNDC15 Gene

No data available for DME Specific Peptides for TXNDC15 Gene

Domains for TXNDC15 Gene

Protein Domains for TXNDC15 Gene


  • Contains 1 thioredoxin domain.:
    • Q96J42
genes like me logo Genes that share domains with TXNDC15: view

No data available for Gene Families for TXNDC15 Gene

Function for TXNDC15 Gene

Phenotypes for TXNDC15 Gene

genes like me logo Genes that share phenotypes with TXNDC15: view

miRNA for TXNDC15 Gene

miRTarBase miRNAs that target TXNDC15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TXNDC15 Gene

Localization for TXNDC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC15 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TXNDC15 Gene COMPARTMENTS Subcellular localization image for TXNDC15 gene
Compartment Confidence
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TXNDC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TXNDC15: view

Pathways for TXNDC15 Gene

SuperPathways for TXNDC15 Gene

No Data Available

Interacting Proteins for TXNDC15 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000351157 for TXNDC15 Gene via STRING

Gene Ontology (GO) - Biological Process for TXNDC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TXNDC15: view

No data available for Pathways by source for TXNDC15 Gene

Transcripts for TXNDC15 Gene

Unigene Clusters for TXNDC15 Gene

Thioredoxin domain containing 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC15 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - - - - - - -
SP7: -

Relevant External Links for TXNDC15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC15 Gene

mRNA expression in normal human tissues for TXNDC15 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXNDC15 Gene

SOURCE GeneReport for Unigene cluster for TXNDC15 Gene Hs.741304

genes like me logo Genes that share expressions with TXNDC15: view

Orthologs for TXNDC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TXNDC15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TXNDC15 36
  • 99.33 (n)
  • 99.43 (a)
TXNDC15 37
  • 99 (a)
(Bos Taurus)
Mammalia TXNDC15 36
  • 87.32 (n)
  • 86.48 (a)
TXNDC15 37
  • 85 (a)
(Canis familiaris)
Mammalia TXNDC15 36
  • 85.06 (n)
  • 86.78 (a)
TXNDC15 37
  • 87 (a)
(Mus musculus)
Mammalia Txndc15 36
  • 79.94 (n)
  • 80.81 (a)
Txndc15 16
Txndc15 37
  • 81 (a)
(Monodelphis domestica)
Mammalia TXNDC15 37
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia TXNDC15 37
  • 74 (a)
(Rattus norvegicus)
Mammalia Txndc15 36
  • 78.62 (n)
  • 80.17 (a)
(Gallus gallus)
Aves TXNDC15 36
  • 63.58 (n)
  • 64.51 (a)
TXNDC15 37
  • 59 (a)
(Anolis carolinensis)
Reptilia TXNDC15 37
  • 82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12492 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7095 36
txndc15 36
  • 64.05 (n)
  • 60.71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11182 36
(Danio rerio)
Actinopterygii Dr.16773 36
TXNDC15 37
  • 52 (a)
zgc:165608 36
  • 60.98 (n)
  • 62.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
Species with no ortholog for TXNDC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC15 Gene

Gene Tree for TXNDC15 (if available)
Gene Tree for TXNDC15 (if available)

Paralogs for TXNDC15 Gene

Selected SIMAP similar genes for TXNDC15 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TXNDC15: view

No data available for Paralogs for TXNDC15 Gene

Variants for TXNDC15 Gene

Sequence variations from dbSNP and Humsavar for TXNDC15 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs319600 -- 134,899,923(-) TACGT(G/T)CATGC utr-variant-3-prime
rs319601 -- 134,887,477(-) GGGCA(C/T)GGTGG intron-variant
rs319602 -- 134,886,474(-) CCTCC(A/G)TAGCA intron-variant
rs2302358 -- 134,874,371(+) CCTTC(C/T)TCCGG utr-variant-5-prime
rs2409826 -- 134,880,645(+) accat(G/T)ttggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC15 Gene

Variant ID Type Subtype PubMed ID
nsv830493 CNV Loss 17160897
nsv830494 CNV Gain+Loss 17160897
esv2674924 CNV Deletion 23128226

Relevant External Links for TXNDC15 Gene

HapMap Linkage Disequilibrium report

Disorders for TXNDC15 Gene

Relevant External Links for TXNDC15

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TXNDC15: view

No data available for UniProtKB/Swiss-Prot for TXNDC15 Gene

Publications for TXNDC15 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 49
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Cell surface thiol isomerases may explain the platelet-selective action of S-nitrosoglutathione. (PMID: 21642008) Xiao F. … Gordge M.P. (Nitric Oxide 2011) 3

Products for TXNDC15 Gene

Sources for TXNDC15 Gene

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