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Aliases for TXNDC12 Gene

Aliases for TXNDC12 Gene

  • Thioredoxin Domain Containing 12 2 3 5
  • Endoplasmic Reticulum Thioredoxin Superfamily Member, 18 KDa 2 3
  • Thioredoxin Domain Containing 12 (Endoplasmic Reticulum) 2 3
  • Protein Disulfide Isomerase Family A, Member 16 2 3
  • Endoplasmic Reticulum Resident Protein 18 3 4
  • Endoplasmic Reticulum Resident Protein 19 3 4
  • Thioredoxin-Like Protein P19 3 4
  • ER Protein 18 3 4
  • ER Protein 19 3 4
  • HTLP19 3 4
  • ERP18 3 4
  • ERP19 3 4
  • TLP19 3 4
  • Anterior Gradient Homolog 1 (Xenopus Laevis) 2
  • Thioredoxin Domain-Containing Protein 12 3
  • Endoplasmic Reticulum Protein ERp19 3
  • Anterior Gradient Homolog 1 3
  • EC 1.8.4.2 4
  • PDIA16 3
  • ERP16 3
  • HAG-1 3
  • AGR1 3
  • AG1 3

External Ids for TXNDC12 Gene

Previous GeneCards Identifiers for TXNDC12 Gene

  • GC01M052199
  • GC01M052485
  • GC01M050603

Summaries for TXNDC12 Gene

Entrez Gene Summary for TXNDC12 Gene

  • This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for TXNDC12 Gene

TXNDC12 (Thioredoxin Domain Containing 12) is a Protein Coding gene. Among its related pathways are Glutathione metabolism. GO annotations related to this gene include protein-disulfide reductase (glutathione) activity. An important paralog of this gene is AGR3.

UniProtKB/Swiss-Prot for TXNDC12 Gene

  • Possesses significant protein thiol-disulfide oxidase activity.

Gene Wiki entry for TXNDC12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC12 Gene

Genomics for TXNDC12 Gene

Regulatory Elements for TXNDC12 Gene

Enhancers for TXNDC12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G051874 1.7 FANTOM5 ENCODE dbSUPER 11.2 +178.7 178705 5.3 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ENSG00000266993 ZCCHC11 TXNDC12 NRDC KTI12 CC2D1B OSBPL9 GC01P051865
GH01G052402 1.4 ENCODE dbSUPER 11.2 -348.1 -348111 3.2 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MAGOH PRPF38A TXNDC12 KTI12 ORC1 PLA2G12AP1
GH01G052032 1.1 ENCODE 11.9 +22.8 22776 2.4 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 CC2D1B TXNDC12 BTF3L4 LOC100190934 ZCCHC11 KTI12 ENSG00000223390
GH01G051728 1.1 ENCODE 11.2 +326.3 326265 3.4 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 TXNDC12 NRDC KTI12 RNU6-877P OSBPL9 GC01P051732 ENSG00000212624
GH01G052053 1.2 ENCODE 10.2 +0.3 343 4.4 MLX CREB3L1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 SSRP1 ZNF610 KTI12 ENSG00000223390 TXNDC12 LOC100190934 TTC39A TXNDC12-AS1 GC01M052055
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TXNDC12 on UCSC Golden Path with GeneCards custom track

Promoters for TXNDC12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000006363 271 3401 MLX CREB3L1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 SSRP1 ZNF610

Genomic Location for TXNDC12 Gene

Chromosome:
1
Start:
52,020,131 bp from pter
End:
52,056,171 bp from pter
Size:
36,041 bases
Orientation:
Minus strand

Genomic View for TXNDC12 Gene

Genes around TXNDC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC12 Gene

Proteins for TXNDC12 Gene

  • Protein details for TXNDC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95881-TXD12_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 12
    Protein Accession:
    O95881
    Secondary Accessions:
    • B3KQS0
    • Q5T1T4
    • Q96H50

    Protein attributes for TXNDC12 Gene

    Size:
    172 amino acids
    Molecular mass:
    19206 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TXNDC12 Gene

neXtProt entry for TXNDC12 Gene

Post-translational modifications for TXNDC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TXNDC12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TXNDC12
  • Santa Cruz Biotechnology (SCBT) Antibodies for TXNDC12

No data available for DME Specific Peptides for TXNDC12 Gene

Domains & Families for TXNDC12 Gene

Gene Families for TXNDC12 Gene

Protein Domains for TXNDC12 Gene

Suggested Antigen Peptide Sequences for TXNDC12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TXNDC12: view

No data available for UniProtKB/Swiss-Prot for TXNDC12 Gene

Function for TXNDC12 Gene

Molecular function for TXNDC12 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=25 uM for Asn-Arg-Cys-Ser-Gln-Gly-Ser-Cys-Trp-Asn; pH dependence: Optimum pH is 6.5.;
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.
UniProtKB/Swiss-Prot Function:
Possesses significant protein thiol-disulfide oxidase activity.

Enzyme Numbers (IUBMB) for TXNDC12 Gene

Gene Ontology (GO) - Molecular Function for TXNDC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015037 peptide disulfide oxidoreductase activity IDA 18628206
GO:0016491 oxidoreductase activity IEA --
GO:0019153 protein-disulfide reductase (glutathione) activity IEA --
genes like me logo Genes that share ontologies with TXNDC12: view
genes like me logo Genes that share phenotypes with TXNDC12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TXNDC12

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNDC12 Gene

Localization for TXNDC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC12 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNDC12 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3

Gene Ontology (GO) - Cellular Components for TXNDC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IDA 18628206
genes like me logo Genes that share ontologies with TXNDC12: view

Pathways & Interactions for TXNDC12 Gene

SuperPathways for TXNDC12 Gene

SuperPathway Contained pathways
1 Glutathione metabolism
genes like me logo Genes that share pathways with TXNDC12: view

Pathways by source for TXNDC12 Gene

1 KEGG pathway for TXNDC12 Gene

Gene Ontology (GO) - Biological Process for TXNDC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IBA --
GO:0045454 cell redox homeostasis IEA --
GO:0055114 oxidation-reduction process IEA --
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA 18628206
genes like me logo Genes that share ontologies with TXNDC12: view

No data available for SIGNOR curated interactions for TXNDC12 Gene

Drugs & Compounds for TXNDC12 Gene

(1) Drugs for TXNDC12 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0

(1) Additional Compounds for TXNDC12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxidized glutathione
  • (2S)-2-azaniumyl-4-{[(1R)-2-{[(2R)-2-[(4S)-4-azaniumyl-4-carboxylatobutanamido]-2-[(carboxylatomethyl)carbamoyl]ethyl]disulfanyl}-1-[(carboxylatomethyl)carbamoyl]ethyl]carbamoyl}butanoate
  • Glutathione disulfide
  • GSSG
  • L(-)-Glutathione(oxidized)
  • Oxiglutatione
27025-41-8
genes like me logo Genes that share compounds with TXNDC12: view

Transcripts for TXNDC12 Gene

Unigene Clusters for TXNDC12 Gene

Thioredoxin domain containing 12 (endoplasmic reticulum):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -
SP6:

Relevant External Links for TXNDC12 Gene

GeneLoc Exon Structure for
TXNDC12
ECgene alternative splicing isoforms for
TXNDC12

Expression for TXNDC12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNDC12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TXNDC12 Gene

This gene is overexpressed in Oral epithelium (11.9) and Bone (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXNDC12 Gene



Protein tissue co-expression partners for TXNDC12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TXNDC12 Gene:

TXNDC12

SOURCE GeneReport for Unigene cluster for TXNDC12 Gene:

Hs.476033

mRNA Expression by UniProt/SwissProt for TXNDC12 Gene:

O95881-TXD12_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TXNDC12 Gene

  • Nervous system(4.9)
  • Intestine(4.4)
  • Liver(4.3)
  • Kidney(4.2)
  • Skin(2.8)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with TXNDC12: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNDC12 Gene

Orthologs for TXNDC12 Gene

This gene was present in the common ancestor of animals.

Orthologs for TXNDC12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNDC12 34 35
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia TXNDC12 34 35
  • 94.19 (n)
dog
(Canis familiaris)
Mammalia TXNDC12 35
  • 94 (a)
OneToOne
LOC609843 34
  • 92.25 (n)
mouse
(Mus musculus)
Mammalia Txndc12 34 16 35
  • 89.62 (n)
rat
(Rattus norvegicus)
Mammalia Txndc12 34
  • 89.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TXNDC12 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TXNDC12 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TXNDC12 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TXNDC12 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc12 34
  • 70.68 (n)
zebrafish
(Danio rerio)
Actinopterygii txndc12 34 35
  • 75.23 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y57A10A.23 34
  • 54.04 (n)
Y57A10A.23 35
  • 35 (a)
ManyToMany
F49H12.5 35
  • 25 (a)
ManyToMany
Species where no ortholog for TXNDC12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNDC12 Gene

ENSEMBL:
Gene Tree for TXNDC12 (if available)
TreeFam:
Gene Tree for TXNDC12 (if available)

Paralogs for TXNDC12 Gene

Paralogs for TXNDC12 Gene

(2) SIMAP similar genes for TXNDC12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TXNDC12: view

Variants for TXNDC12 Gene

Sequence variations from dbSNP and Humsavar for TXNDC12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000100415 -- 52,031,317(+) ACCAC(A/G)CCCGG intron-variant
rs1000135208 -- 52,042,344(+) TAAAG(A/G)TCCAA intron-variant
rs1000169168 -- 52,037,205(+) AGACC(A/C)CCTTT intron-variant
rs1000206401 -- 52,056,239(+) CCCCG(C/G)AGAGG upstream-variant-2KB, utr-variant-5-prime
rs1000322937 -- 52,056,435(+) GGTCT(A/C)CCCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TXNDC12 Gene

Variant ID Type Subtype PubMed ID
nsv1004103 CNV loss 25217958
nsv829848 CNV loss 17160897

Variation tolerance for TXNDC12 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNDC12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNDC12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC12 Gene

Disorders for TXNDC12 Gene

Relevant External Links for TXNDC12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXNDC12

No disorders were found for TXNDC12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC12 Gene

Publications for TXNDC12 Gene

  1. Solution structure and dynamics of ERp18, a small endoplasmic reticulum resident oxidoreductase. (PMID: 19361226) Rowe M.L. … Howard M.J. (Biochemistry 2009) 3 4 22 64
  2. Functional characterization of ERp18, a new endoplasmic reticulum- located thioredoxin superfamily member. (PMID: 12761212) Alanen H.I. … Ruddock L.W. (J. Biol. Chem. 2003) 3 4 22 64
  3. Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein. (PMID: 14557066) Liu F. … Han Z.G. (Gene 2003) 3 4 22 64
  4. Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins. (PMID: 19887585) Jessop C.E. … Bulleid N.J. (J. Cell. Sci. 2009) 3 22 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for TXNDC12 Gene

Sources for TXNDC12 Gene

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