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TXNDC12 Gene

protein-coding   GIFtS: 57
GCID: GC01M052485

Thioredoxin Domain Containing 12 (Endoplasmic Reticulum)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thioredoxin Domain Containing 12 (Endoplasmic Reticulum)1 2     AG12
TLP192 3 5     AGR12
Endoplasmic Reticulum Resident Protein 182 3     ERP162
Endoplasmic Reticulum Resident Protein 192 3     ERP192
Thioredoxin-Like Protein P192 3     PDIA162
ER Protein 182 3     Anterior Gradient Homolog 12
ER Protein 192 3     Endoplasmic Reticulum Protein ERp192
hTLP192 3     Endoplasmic Reticulum Thioredoxin Superfamily Member, 18 KDa2
ERP182 5     hAG-12
18 KDa1     Protein Disulfide Isomerase Family A, Member 162
Anterior Gradient Homolog 1 (Xenopus Laevis)1     Thioredoxin Domain-Containing Protein 122
Endoplasmic Reticulum Thioredoxin Superfamily Member1     EC 1.8.4.23
Member 161     ERp183
Protein Disulfide Isomerase Family A1     ERp193

External Ids:    HGNC: 246261   Entrez Gene: 510602   Ensembl: ENSG000001178627   OMIM: 6094485   UniProtKB: O958813   

Export aliases for TXNDC12 gene to outside databases

Previous GC identifers: GC01M052199 GC01M050603


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TXNDC12 Gene:
This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved
active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein
localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly
involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide
isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing
results in both coding and non-coding variants. (provided by RefSeq, Mar 2012)

GeneCards Summary for TXNDC12 Gene:
TXNDC12 (thioredoxin domain containing 12 (endoplasmic reticulum)) is a protein-coding gene. GO annotations related to this gene include protein-disulfide reductase (glutathione) activity. An important paralog of this gene is AGR2.

UniProtKB/Swiss-Prot: TXD12_HUMAN, O95881
Function: Possesses significant protein thiol-disulfide oxidase activity

Gene Wiki entry for TXNDC12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TXNDC12 gene promoter:
         Elk-1   RFX1   AML1a   HOXA3   IRF-1   IRF-2   c-Myb   Sox9   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXNDC12 promoter sequence
   Search Chromatin IP Primers for TXNDC12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXNDC12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

TXNDC12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNDC12 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M052485:  view genomic region     (about GC identifiers)

Start:
52,485,803 bp from pter      End:
52,521,843 bp from pter
Size:
36,041 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TXD12_HUMAN, O95881 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 12 precursor  
Size: 172 amino acids; 19206 Da
2 PDB 3D structures from and Proteopedia for TXNDC12:
1SEN (3D)        2K8V (3D)    
Secondary accessions: B3KQS0 Q5T1T4 Q96H50

Explore the universe of human proteins at neXtProt for TXNDC12: NX_O95881

Explore proteomics data for TXNDC12 at MOPED


See TXNDC12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_056997.1  
ENSEMBL proteins: 
 ENSP00000360688   ENSP00000477120   ENSP00000476401  

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antibodies-online proteins for TXNDC12 (9 products) 

 
antibodies-online peptides for TXNDC12

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PDI: Protein disulfide isomerases

2 InterPro protein domains:
 IPR012336 Thioredoxin-like_fold
 IPR017937 Thioredoxin_CS

Graphical View of Domain Structure for InterPro Entry O95881

ProtoNet protein and cluster: O95881

1 Blocks protein domain: IPB006662 Thioredoxin type domain

UniProtKB/Swiss-Prot: TXD12_HUMAN, O95881
Similarity: Contains 1 thioredoxin domain


Find genes that share domains with TXNDC12           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TXD12_HUMAN, O95881
Function: Possesses significant protein thiol-disulfide oxidase activity
Catalytic activity: 2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol
Biophysicochemical properties: Kinetic parameters: KM=25 uM for Asn-Arg-Cys-Ser-Gln-Gly-Ser-Cys-Trp-Asn; pH
dependence: Optimum pH is 6.5;

     Enzyme Number (IUBMB): EC 1.8.4.21

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0019153protein-disulfide reductase (glutathione) activity IEA--
     
Find genes that share ontologies with TXNDC12           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for TXNDC12:
 Increased Salmonella enterica  

     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Txndc12):
 normal 

Find genes that share phenotypes with TXNDC12           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for TXNDC12

miRNA
Products:
    
miRTarBase miRNAs that target TXNDC12:
hsa-mir-155-5p (MIRT001490)

Block miRNA regulation of human, mouse, rat TXNDC12 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate TXNDC12 (see all 18):
hsa-miR-3938 hsa-miR-16-2* hsa-miR-181c hsa-miR-515-5p hsa-miR-2115 hsa-miR-24 hsa-miR-181b hsa-miR-3671
SwitchGear 3'UTR luciferase reporter plasmidTXNDC12 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat TXNDC12

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GenScript: all cDNA clones in your preferred vector: TXNDC12 (NM_015913)
Sino Biological Human cDNA Clone for TXNDC12
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC12

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC12


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TXD12_HUMAN, O95881: Endoplasmic reticulum lumen
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
mitochondrion5
nucleus5
cytosol4
extracellular3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005788endoplasmic reticulum lumen IEA--

Find genes that share ontologies with TXNDC12           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TXNDC12 About    
See pathways by source

SuperPathContained pathways About
1Glutathione metabolism
Glutathione metabolism0.65
glutathione redox reactions II0.00


Find genes that share SuperPaths with TXNDC12           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for TXNDC12
    glutathione redox reactions II



1 Kegg Pathway  (Kegg details for TXNDC12):
    Glutathione metabolism

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TXNDC12
Interactions:

    Search GeneGlobe Interaction Network for TXNDC12

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TXNDC12 (O958813 ENSP000003606884) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
InteractantInteraction Details
GeneCardExternal ID(s)
H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
SLC2A4P146723I2D: score=1 
YES1P079473I2D: score=1 
GSSENSP000002169514STRING: ENSP00000216951
GSTA1ENSP000003356204STRING: ENSP00000335620
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0045454cell redox homeostasis IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TXNDC12 (TXD12)

2 HMDB Compounds for TXNDC12    About this table
CompoundSynonyms CAS #PubMed Ids
Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
Oxidized glutathioneGSSG (see all 4)27025-41-8--

1 DrugBank Compound for TXNDC12    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17139284 17016423



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TXNDC12 gene: 
NM_015913.3  

Unigene Cluster for TXNDC12:

Thioredoxin domain containing 12 (endoplasmic reticulum)
Hs.476033  [show with all ESTs]
Unigene Representative Sequence: NR_046405
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000469458 ENST00000371626(uc001cti.3) ENST00000472624 ENST00000471493
ENST00000610127
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate TXNDC12 (see all 18):
hsa-miR-3938 hsa-miR-16-2* hsa-miR-181c hsa-miR-515-5p hsa-miR-2115 hsa-miR-24 hsa-miR-181b hsa-miR-3671
SwitchGear 3'UTR luciferase reporter plasmidTXNDC12 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat TXNDC12
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TXNDC12
  QuantiTect SYBR Green Assays in human, mouse, rat TXNDC12
  QuantiFast Probe-based Assays in human, mouse, rat TXNDC12

Additional mRNA sequence: 

AF131758.1 AF327348.1 AF543416.1 AK056169.1 AK075409.1 AK094262.1 AK313746.1 AY358982.1 
BC001493.2 BC008913.2 BC008953.2 BC012173.1 L31901.1 NR_046405.1 NR_046406.1 

14 DOTS entries:

DT.100830610  DT.100810559  DT.100784551  DT.456295  DT.448982  DT.100784550  DT.121387150  DT.121387181 
DT.91760897  DT.99927912  DT.100638266  DT.100810560  DT.95177763  DT.95223987 

Selected AceView cDNA sequences (see all 346):

Z46177 AI367461 BQ678695 CD723339 BU543493 BX345507 BG198452 AI879750 
AW129516 AI081363 AI350057 BQ019646 CA447295 BF796813 BU153874 BM667331 
AW166966 BQ774552 BG740090 BP870969 BM126705 BG031760 N75179 BQ228209 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC12 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1:                    -           -     -     -     -                 -                 -         
SP2:                    -           -     -                             -                           
SP3:                                -     -                                                         
SP4:                                            -     -                                             
SP5:                    -                                                                           


ECgene alternative splicing isoforms for TXNDC12

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TXNDC12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTTTCCCTTG
TXNDC12 Expression
About this image


TXNDC12 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Eye (Sensory Organs)
         Lens
 
 Neural Tube (Nervous System)
         Telencephalon
 
 Brain (Nervous System)
         Cerebral Cortex
TXNDC12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TXNDC12 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.476033

UniProtKB/Swiss-Prot: TXD12_HUMAN, O95881
Tissue specificity: Widely expressed

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QuantiFast Probe-based Assays in human, mouse, rat TXNDC12
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC12

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TXNDC12 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Txndc121 , 5 thioredoxin domain containing 12 (endoplasmic reticulum)1, 5 89.62(n)1
92.81(a)1
  4 (50.64 cM)5
660731  NM_025334.31  NP_079610.11 
 1088346015 
chicken
(Gallus gallus)
Aves TXNDC126
thioredoxin domain containing 12 (endoplasmic reti...
78(a)
1 ↔ 1
8(23149240-23159464)
lizard
(Anolis carolinensis)
Reptilia TXNDC126
thioredoxin domain containing 12 (endoplasmic reti...
81(a)
1 ↔ 1
4(114376184-114387545)
African clawed frog
(Xenopus laevis)
Amphibia BC044076.12   -- 76.21(n)    BC044076.1 
zebrafish
(Danio rerio)
Actinopterygii txndc121 thioredoxin domain containing 12 (endoplasmic reticulum) 75.23(n)
81.08(a)
  324900  NM_001020824.1  NP_001018660.1 
worm
(Caenorhabditis elegans)
Secernentea CELE_Y57A10A.231 CELE_Y57A10A.23 54.04(n)
44.7(a)
  174863  NM_064198.4  NP_496599.1 


ENSEMBL Gene Tree for TXNDC12 (if available)
TreeFam Gene Tree for TXNDC12 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TXNDC12 gene
AGR22  AGR32  
2 SIMAP similar genes for TXNDC12 using alignment to 3 protein entries:     TXD12_HUMAN (see all proteins):
AGR2    AGR3

Find genes that share paralogs with TXNDC12           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TXNDC12 (see all 566)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1920817621,2
--52485329(+) TCACCA/GCGCCC 1 -- ds50010--------
rs798432681,2
C,F--52485335(+) CGCCCA/GGCCTA 1 -- ds50011Minor allele frequency- G:0.00NA 2
rs1456933771,2
C--52485340(+) GGCCTA/TATTTT 1 -- ds50010--------
rs1489322811,2
--52485459(+) GTGAGC/TCACTG 1 -- ds50010--------
rs773934461,2
C,F--52485530(+) ATATTA/GGAGCC 1 -- ds50012Minor allele frequency- G:0.17CSA WA 120
rs1165903571,2
C,F--52485594(+) GCCCCG/ATGCTA 1 -- ds50011Minor allele frequency- A:0.03WA 118
rs1846570201,2
--52485917(+) GGCTTC/GAAGGT 1 -- ut310--------
rs1895209251,2
--52486050(+) AGGCTA/GTAGAA 1 -- ut310--------
rs75120761,2
C,F,A,H--52486104(+) AAAAAC/TAGGCT 1 -- ut31 ese322Minor allele frequency- T:0.05NA NS EA CSA WA 2538
rs760001531,2
C,F--52486163(+) TGTTAT/CTGTTG 1 -- ut311Minor allele frequency- C:0.10EA 120

HapMap Linkage Disequilibrium report for TXNDC12 (52485803 - 52521843 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TXNDC12:    About this table    
Variant IDTypeSubtypePubMed ID
nsv829848CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609448    OMIM disorders: --


Find genes that share disorders with TXNDC12           About GenesLikeMe


Export disorders for TXNDC12 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TXNDC12 gene, integrated from 10 sources (see all 26):
(articles sorted by number of sources associating them with TXNDC12)
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world of online information

  1. Solution structure and dynamics of ERp18, a small endoplasmic reticulum resident oxidoreductase. (PubMed id 19361226)1, 2, 9 Rowe M.L....Howard M.J. (Biochemistry 2009)
  2. Functional characterization of ERp18, a new endoplasmic reticulum- located thioredoxin superfamily member. (PubMed id 12761212)1, 2, 9 Alanen H.I.... Ruddock L.W. (J. Biol. Chem. 2003)
  3. Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein. (PubMed id 14557066)1, 2, 9 Liu F.... Han Z.G. (Gene 2003)
  4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
  8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  9. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
  10. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51060 HGNC: 24626 AceView: TLP19 Ensembl:ENSG00000117862 euGenes: HUgn51060
ECgene: TXNDC12 Kegg: 51060 H-InvDB: TXNDC12

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TXNDC12 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TXNDC12 gene:
Search GeneIP for patents involving TXNDC12

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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