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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TXNDC12 Gene

protein-coding   GIFtS: 59
GCID: GC01M052485

Thioredoxin Domain Containing 12 (Endoplasmic Reticulum)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thioredoxin Domain Containing 12 (Endoplasmic Reticulum)1 2     AG12
TLP192 3 5     AGR12
Endoplasmic Reticulum Resident Protein 182 3     ERP162
Endoplasmic Reticulum Resident Protein 192 3     ERP192
Thioredoxin-Like Protein P192 3     PDIA162
ER Protein 182 3     Anterior Gradient Homolog 12
ER Protein 192 3     Endoplasmic Reticulum Protein ERp192
hTLP192 3     Endoplasmic Reticulum Thioredoxin Superfamily Member, 18 KDa2
ERP182 5     hAG-12
18 KDa1     Protein Disulfide Isomerase Family A, Member 162
Anterior Gradient Homolog 1 (Xenopus Laevis)1     Thioredoxin Domain-Containing Protein 122
Endoplasmic Reticulum Thioredoxin Superfamily Member1     EC 1.8.4.23
Member 161     ERp183
Protein Disulfide Isomerase Family A1     ERp193

External Ids:    HGNC: 246261   Entrez Gene: 510602   Ensembl: ENSG000001178627   OMIM: 6094485   UniProtKB: O958813   

Export aliases for TXNDC12 gene to outside databases

Previous GC identifers: GC01M052199 GC01M050603


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TXNDC12 Gene:
This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved
active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein
localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly
involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide
isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing
results in both coding and non-coding variants. (provided by RefSeq, Mar 2012)

GeneCards Summary for TXNDC12 Gene: 
TXNDC12 (thioredoxin domain containing 12 (endoplasmic reticulum)) is a protein-coding gene. Diseases associated with TXNDC12 include cellulitis, and hepatocellular carcinoma, and among its related super-pathways are Glutathione metabolism. GO annotations related to this gene include protein-disulfide reductase (glutathione) activity. An important paralog of this gene is AGR2.

UniProtKB/Swiss-Prot: TXD12_HUMAN, O95881
Function: Possesses significant protein thiol-disulfide oxidase activity

Gene Wiki entry for TXNDC12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TXNDC12 gene promoter:
         Elk-1   RFX1   AML1a   HOXA3   IRF-1   IRF-2   c-Myb   Sox9   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXNDC12 promoter sequence
   Search SABiosciences Chromatin IP Primers for TXNDC12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

TXNDC12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNDC12 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M052485:  view genomic region     (about GC identifiers)

Start:
52,485,803 bp from pter      End:
52,521,843 bp from pter
Size:
36,041 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TXD12_HUMAN, O95881 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 12 precursor  
Size: 172 amino acids; 19206 Da
Subcellular location: Endoplasmic reticulum lumen
2 PDB 3D structures from and Proteopedia for TXNDC12:
1SEN (3D)        2K8V (3D)    
Secondary accessions: B3KQS0 Q5T1T4 Q96H50

Explore the universe of human proteins at neXtProt for TXNDC12: NX_O95881

Explore proteomics data for TXNDC12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95881

  • TXNDC12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TXNDC12 Protein Expression
    REFSEQ proteins: NP_056997.1  
    ENSEMBL proteins: 
     ENSP00000360688  

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    Cloud-Clone Corp. Proteins for TXNDC12 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen IEA--

    TXNDC12 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PDI: Protein disulfide isomerases

    2 InterPro protein domains:
     IPR017937 Thioredoxin_CS
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry O95881

    ProtoNet protein and cluster: O95881

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TXD12_HUMAN, O95881
    Similarity: Contains 1 thioredoxin domain


    TXNDC12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXD12_HUMAN, O95881
    Function: Possesses significant protein thiol-disulfide oxidase activity
    Catalytic activity: 2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol
    Biophysicochemical properties: Kinetic parameters: KM=25 uM for Asn-Arg-Cys-Ser-Gln-Gly-Ser-Cys-Trp-Asn; pH
    dependence: Optimum pH is 6.5;

         Enzyme Number (IUBMB): EC 1.8.4.21

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019153protein-disulfide reductase (glutathione) activity IEA--
         
    TXNDC12 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TXNDC12:
     Increased Salmonella enterica  

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Txndc12):
     normal 

    TXNDC12 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TXNDC12 
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    miRNA
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    miRTarBase miRNAs that target TXNDC12:
    hsa-mir-155 (MIRT001490)

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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNDC12 (see all 18):
    hsa-miR-3938 hsa-miR-16-2* hsa-miR-181c hsa-miR-515-5p hsa-miR-2115 hsa-miR-24 hsa-miR-181b hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidTXNDC12 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TXNDC12 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.67
    2glutathione redox reactions II
    glutathione redox reactions II

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TXNDC12
        glutathione redox reactions II


    1         Kegg Pathway  (Kegg details for TXNDC12):
        Glutathione metabolism


    TXNDC12 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TXNDC12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for TXNDC12 (O958813 ENSP000003606884) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
    SLC2A4P146723I2D: score=1 
    YES1P079473I2D: score=1 
    GSSENSP000002169514STRING: ENSP00000216951
    GSTA1ENSP000003356204STRING: ENSP00000335620
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045454cell redox homeostasis IEA--

    TXNDC12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TXNDC12 (TXD12)

    2 HMDB Compounds for TXNDC12    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Oxidized glutathioneGSSG (see all 4)27025-41-8--

    1 DrugBank Compound for TXNDC12    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about TXNDC12 / TXD12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TXNDC12 gene: 
    NM_015913.3  

    Unigene Cluster for TXNDC12:

    Thioredoxin domain containing 12 (endoplasmic reticulum)
    Hs.476033  [show with all ESTs]
    Unigene Representative Sequence: NR_046405
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469458 ENST00000371626(uc001cti.3) ENST00000472624 ENST00000471493

    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNDC12 (see all 18):
    hsa-miR-3938 hsa-miR-16-2* hsa-miR-181c hsa-miR-515-5p hsa-miR-2115 hsa-miR-24 hsa-miR-181b hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidTXNDC12 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC12
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    Additional mRNA sequence: 

    AF131758.1 AF327348.1 AF543416.1 AK056169.1 AK075409.1 AK094262.1 AK313746.1 AY358982.1 
    BC001493.2 BC008913.2 BC008953.2 BC012173.1 L31901.1 NR_046405.1 NR_046406.1 

    14 DOTS entries:

    DT.100830610  DT.100810559  DT.100784551  DT.456295  DT.448982  DT.100784550  DT.121387150  DT.121387181 
    DT.91760897  DT.99927912  DT.100638266  DT.100810560  DT.95177763  DT.95223987 

    24/346 AceView cDNA sequences (see all 346):

    BM984891 CD723339 CA447295 BG110865 BU607921 CB052305 AA503199 BQ228209 
    BQ677909 BU171719 BE727147 BQ428514 T36043 AA720895 BM710615 Z46177 
    AI379126 AA890535 BU178396 BU153874 CA418006 CD367873 R14938 BM126705 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC12 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                    -           -     -     -     -                 -                 -         
    SP2:                    -           -     -                             -                           
    SP3:                                -     -                                                         
    SP4:                                            -     -                                             
    SP5:                    -                                                                           


    ECgene alternative splicing isoforms for TXNDC12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TXNDC12 expression in normal human tissues (normalized intensities)      TXNDC12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCCCTTG
    TXNDC12 Expression
    About this image


    TXNDC12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             brain/midbrain   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium   
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   
     
     Cartilage (Muscoskeletal System)
             skeleton/cranium   

    See TXNDC12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TXNDC12

    SOURCE GeneReport for Unigene cluster: Hs.476033

    UniProtKB/Swiss-Prot: TXD12_HUMAN, O95881
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for TXNDC12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TXNDC12 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txndc121 , 5 thioredoxin domain containing 12 (endoplasmic reticulum)1, 5 89.62(n)1
    92.81(a)1
      4 (50.64 cM)5
    660731  NM_025334.31  NP_079610.11 
     1088346015 
    chicken
    (Gallus gallus)
    Aves TXNDC121 thioredoxin domain containing 12 (endoplasmic reticulum) 76.53(n)
    78.7(a)
      772208  XM_001235372.2  XP_001235373.1 
    lizard
    (Anolis carolinensis)
    Reptilia TXNDC126
    thioredoxin domain containing 12 (endoplasmic reti...
    78(a)
    1 ↔ 1
    4(114376184-114387545)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044076.12   -- 76.21(n)    BC044076.1 
    zebrafish
    (Danio rerio)
    Actinopterygii txndc121 thioredoxin domain containing 12 (endoplasmic reticulum) 75.23(n)
    81.08(a)
      324900  NM_001020824.1  NP_001018660.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y57A10A.231 Protein Y57A10A.23 54.76(n)
    46.03(a)
      174863  NM_064198.3  NP_496599.1 


    ENSEMBL Gene Tree for TXNDC12 (if available)
    TreeFam Gene Tree for TXNDC12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TXNDC12 gene
    AGR22  AGR32  
    2 SIMAP similar genes for TXNDC12 using alignment to 1 protein entry:     TXD12_HUMAN:
    AGR2    AGR3

    TXNDC12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/566 SNPs in TXNDC12 are shown (see all 566)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920817621,2
    --52485329(+) TCACCA/GCGCCC 1 -- ds50010--------
    rs798432681,2
    C,F--52485335(+) CGCCCA/GGCCTA 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs1456933771,2
    C--52485340(+) GGCCTA/TATTTT 1 -- ds50010--------
    rs1489322811,2
    --52485459(+) GTGAGC/TCACTG 1 -- ds50010--------
    rs773934461,2
    C,F--52485530(+) ATATTA/GGAGCC 1 -- ds50012Minor allele frequency- G:0.17CSA WA 120
    rs1165903571,2
    C,F--52485594(+) GCCCCG/ATGCTA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1846570201,2
    --52485917(+) GGCTTC/GAAGGT 1 -- ut310--------
    rs1895209251,2
    --52486050(+) AGGCTA/GTAGAA 1 -- ut310--------
    rs75120761,2
    C,F,A,H--52486104(+) AAAAAC/TAGGCT 1 -- ut31 ese322Minor allele frequency- T:0.05NA NS EA CSA WA 2538
    rs760001531,2
    C,F--52486163(+) TGTTAT/CTGTTG 1 -- ut311Minor allele frequency- C:0.10EA 120

    HapMap Linkage Disequilibrium report for TXNDC12 (52485803 - 52521843 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TXNDC12:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829848CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609448    OMIM disorders: --

    3 diseases for TXNDC12:    About MalaCards
    cellulitis    hepatocellular carcinoma    neuronitis


    TXNDC12 for disorders           About GeneDecksing


    Export disorders for TXNDC12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TXNDC12 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with TXNDC12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Solution structure and dynamics of ERp18, a small end oplasmic reticulum resident oxidoreductase . (PubMed id 19361226)1, 2, 9 Rowe M.L....Howard M.J. (2009)
    2. Functional characterization of ERp18, a new endoplasmic reticulum- located thioredoxin superfamily member. (PubMed id 12761212)1, 2, 9 Alanen H.I.... Ruddock L.W. (2003)
    3. Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein. (PubMed id 14557066)1, 2, 9 Liu F.... Han Z.G. (2003)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
    10. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51060 HGNC: 24626 AceView: TLP19 Ensembl:ENSG00000117862 euGenes: HUgn51060
    ECgene: TXNDC12 Kegg: 51060 H-InvDB: TXNDC12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TXNDC12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TXNDC12 gene:
    Search GeneIP for patents involving TXNDC12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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