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Aliases for TXNDC11 Gene

Aliases for TXNDC11 Gene

  • Thioredoxin Domain Containing 11 2 3 5
  • EF-Hand Binding Protein 1 2 3
  • EFP1 3 4
  • Thioredoxin Domain-Containing Protein 11 3
  • EF-Hand-Binding Protein 1 4

External Ids for TXNDC11 Gene

Previous GeneCards Identifiers for TXNDC11 Gene

  • GC16M011681
  • GC16M011772

Summaries for TXNDC11 Gene

GeneCards Summary for TXNDC11 Gene

TXNDC11 (Thioredoxin Domain Containing 11) is a Protein Coding gene. GO annotations related to this gene include protein disulfide isomerase activity.

UniProtKB/Swiss-Prot for TXNDC11 Gene

  • May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC11 Gene

Genomics for TXNDC11 Gene

Regulatory Elements for TXNDC11 Gene

Enhancers for TXNDC11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G011667 1.6 FANTOM5 ENCODE dbSUPER 24.2 +72.5 72486 6.7 SIN3A ZNF48 GLIS2 ZNF143 FOS SP5 MXD4 NFYC REST TBX21 ZC3H7A TXNDC11 LITAF LOC105371084 ENSG00000261560 SNN HNRNPCP4 RSL1D1 COX6CP1 SNX29
GH16G011611 2 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +128.7 128657 4.8 PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 LITAF ENSG00000261560 TXNDC11 LOC105371084 HNRNPCP4 COX6CP1 ENSG00000261216 SOCS1 SNN ZC3H7A
GH16G011674 2 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +63.5 63546 9.9 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 TXNDC11 ZC3H7A SNN LITAF SNX29 SOCS1 ENSG00000262420
GH16G011689 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.5 +53.3 53293 2.5 ELF3 HDGF PKNOX1 FOXA2 FEZF1 BMI1 YBX1 ZBTB40 YY1 ZNF121 TXNDC11 SNN LITAF SNX29 SOCS1 ENSG00000262420
GH16G011639 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +102.2 102221 3.3 FOXA2 PKNOX1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766 LITAF LOC105371084 ENSG00000261560 ZC3H7A HNRNPCP4 SNN LOC400499 ENSG00000261216 COX6CP1 TXNDC11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TXNDC11 on UCSC Golden Path with GeneCards custom track

Promoters for TXNDC11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000083385 478 2401 MLX CREB3L1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for TXNDC11 Gene

Chromosome:
16
Start:
11,679,080 bp from pter
End:
11,742,878 bp from pter
Size:
63,799 bases
Orientation:
Minus strand

Genomic View for TXNDC11 Gene

Genes around TXNDC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC11 Gene

Proteins for TXNDC11 Gene

  • Protein details for TXNDC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PKC3-TXD11_HUMAN
    Recommended name:
    Thioredoxin domain-containing protein 11
    Protein Accession:
    Q6PKC3
    Secondary Accessions:
    • O95887
    • Q6PJA6
    • Q8N2Q4
    • Q96K45
    • Q96K53

    Protein attributes for TXNDC11 Gene

    Size:
    985 amino acids
    Molecular mass:
    110529 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA.
    SequenceCaution:
    • Sequence=AAD20043.1; Type=Frameshift; Positions=618; Evidence={ECO:0000305}; Sequence=AAH13727.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55129.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11044.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for TXNDC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TXNDC11 Gene

Post-translational modifications for TXNDC11 Gene

  • Glycosylation at Asn326 and Asn337
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TXNDC11 Gene

Domains & Families for TXNDC11 Gene

Protein Domains for TXNDC11 Gene

Suggested Antigen Peptide Sequences for TXNDC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PKC3

UniProtKB/Swiss-Prot:

TXD11_HUMAN :
  • Belongs to the protein disulfide isomerase family.
Family:
  • Belongs to the protein disulfide isomerase family.
genes like me logo Genes that share domains with TXNDC11: view

No data available for Gene Families for TXNDC11 Gene

Function for TXNDC11 Gene

Molecular function for TXNDC11 Gene

UniProtKB/Swiss-Prot Function:
May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.

Gene Ontology (GO) - Molecular Function for TXNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IBA --
GO:0005515 protein binding IPI 18985028
genes like me logo Genes that share ontologies with TXNDC11: view
genes like me logo Genes that share phenotypes with TXNDC11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TXNDC11

CRISPR Products

miRNA for TXNDC11 Gene

miRTarBase miRNAs that target TXNDC11

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNDC11 Gene

Localization for TXNDC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC11 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNDC11 gene
Compartment Confidence
plasma membrane 4
cytosol 4
endoplasmic reticulum 3
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TXNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005783 endoplasmic reticulum IBA,IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TXNDC11: view

Pathways & Interactions for TXNDC11 Gene

SuperPathways for TXNDC11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0034976 response to endoplasmic reticulum stress IBA --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TXNDC11: view

No data available for Pathways by source and SIGNOR curated interactions for TXNDC11 Gene

Drugs & Compounds for TXNDC11 Gene

No Compound Related Data Available

Transcripts for TXNDC11 Gene

Unigene Clusters for TXNDC11 Gene

Thioredoxin domain containing 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: -
SP3:
SP4: -
SP5: - - - -
SP6: - - -
SP7:
SP8:
SP9: - - - -

Relevant External Links for TXNDC11 Gene

GeneLoc Exon Structure for
TXNDC11
ECgene alternative splicing isoforms for
TXNDC11

Expression for TXNDC11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNDC11 Gene

Protein differential expression in normal tissues from HIPED for TXNDC11 Gene

This gene is overexpressed in Tlymphocyte (26.6), Stomach (14.2), Liver (9.0), and Spinal cord (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXNDC11 Gene



NURSA nuclear receptor signaling pathways regulating expression of TXNDC11 Gene:

TXNDC11

SOURCE GeneReport for Unigene cluster for TXNDC11 Gene:

Hs.313847

mRNA Expression by UniProt/SwissProt for TXNDC11 Gene:

Q6PKC3-TXD11_HUMAN
Tissue specificity: Widely expressed at low level. Expressed at higher level in thyroid and prostate.

Evidence on tissue expression from TISSUES for TXNDC11 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with TXNDC11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNDC11 Gene

Orthologs for TXNDC11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TXNDC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXNDC11 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TXNDC11 34 35
  • 88.61 (n)
cow
(Bos Taurus)
Mammalia TXNDC11 34 35
  • 87.5 (n)
mouse
(Mus musculus)
Mammalia Txndc11 34 16 35
  • 83.3 (n)
rat
(Rattus norvegicus)
Mammalia Txndc11 34
  • 82.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TXNDC11 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 73 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves TXNDC11 34 35
  • 68.88 (n)
lizard
(Anolis carolinensis)
Reptilia TXNDC11 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc11 34
  • 62.31 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330433 34
  • 56.28 (n)
txndc11 35
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13671 35
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
CSA.8061 35
  • 22 (a)
OneToMany
Species where no ortholog for TXNDC11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC11 Gene

ENSEMBL:
Gene Tree for TXNDC11 (if available)
TreeFam:
Gene Tree for TXNDC11 (if available)

Paralogs for TXNDC11 Gene

Pseudogenes.org Pseudogenes for TXNDC11 Gene

genes like me logo Genes that share paralogs with TXNDC11: view

No data available for Paralogs for TXNDC11 Gene

Variants for TXNDC11 Gene

Sequence variations from dbSNP and Humsavar for TXNDC11 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000022319 -- 11,702,470(+) CAAGA(A/C)CAGCC intron-variant
rs1000038569 -- 11,742,190(+) CCCCT(A/C)GTGAC intron-variant
rs1000091654 -- 11,707,451(+) TTTTC(C/T)CAATT intron-variant
rs1000130010 -- 11,707,296(+) CGCCT(A/G)TAGTC intron-variant
rs1000164885 -- 11,706,432(+) ATCTA(C/G)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC11 Gene

Variant ID Type Subtype PubMed ID
esv2662947 CNV deletion 23128226
esv3637933 CNV loss 21293372
esv3637934 CNV gain 21293372
esv3637935 CNV loss 21293372
esv3637936 CNV gain 21293372
nsv1734 CNV insertion 18451855
nsv457409 CNV gain 19166990
nsv478577 CNV novel sequence insertion 20440878
nsv524676 CNV loss 19592680
nsv525726 CNV gain 19592680
nsv571456 CNV gain 21841781

Variation tolerance for TXNDC11 Gene

Residual Variation Intolerance Score: 44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.57; 97.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXNDC11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXNDC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC11 Gene

Disorders for TXNDC11 Gene

Relevant External Links for TXNDC11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXNDC11

No disorders were found for TXNDC11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC11 Gene

Publications for TXNDC11 Gene

  1. Identification of a novel partner of duox: EFP1, a thioredoxin- related protein. (PMID: 15561711) Wang D. … Miot F. (J. Biol. Chem. 2005) 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 64
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 64

Products for TXNDC11 Gene

Sources for TXNDC11 Gene

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