Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TXNDC11 Gene

protein-coding   GIFtS: 47
GCID: GC16M011772

Thioredoxin Domain Containing 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thioredoxin Domain Containing 111 2
EF-Hand Binding Protein 11 2
EFP12 3
EF-Hand-Binding Protein 12 3
Thioredoxin Domain-Containing Protein 112

External Ids:    HGNC: 280301   Entrez Gene: 510612   Ensembl: ENSG000001530667   UniProtKB: Q6PKC33   

Export aliases for TXNDC11 gene to outside databases

Previous GC identifer: GC16M011681


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TXNDC11 Gene: 
TXNDC11 (thioredoxin domain containing 11) is a protein-coding gene. Diseases associated with TXNDC11 include macular degeneration, and ataxia.

UniProtKB/Swiss-Prot: TXD11_HUMAN, Q6PKC3
Function: May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2
suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is
however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TXNDC11 gene promoter:
         Nkx3-1   p53   RREB-1   ATF-2   Nkx3-1 v1   E47   Nkx3-1 v2   HEN1   Nkx3-1 v3   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXNDC11 promoter sequence
   Search SABiosciences Chromatin IP Primers for TXNDC11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.13   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13.13

TXNDC11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNDC11 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M011772:  view genomic region     (about GC identifiers)

Start:
11,772,936 bp from pter      End:
11,836,734 bp from pter
Size:
63,799 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TXD11_HUMAN, Q6PKC3 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 11  
Size: 985 amino acids; 110529 Da
Subunit: Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAD20043.1; Type=Frameshift; Positions=618; Sequence=AAH13727.1; Type=Erroneous
initiation; Sequence=BAB55129.1; Type=Erroneous initiation; Sequence=BAC11044.1; Type=Miscellaneous discrepancy;
Note=Intron retention;
Secondary accessions: O95887 Q6PJA6 Q8N2Q4 Q96K45 Q96K53
Alternative splicing: 3 isoforms:  Q6PKC3-1   Q6PKC3-2   Q6PKC3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TXNDC11: NX_Q6PKC3

Explore proteomics data for TXNDC11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PKC3

  • TXNDC11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TXNDC11 Protein Expression
    REFSEQ proteins: NP_056998.4  
    ENSEMBL proteins: 
     ENSP00000283033   ENSP00000349439   ENSP00000458263   ENSP00000458687   ENSP00000460058  

    Human Recombinant Protein Products for TXNDC11: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TXNDC11
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for TXNDC11 
    OriGene Custom Protein Services for TXNDC11
    GenScript Custom Purified and Recombinant Proteins Services for TXNDC11
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TXNDC11 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    TXNDC11 for ontologies           About GeneDecksing



    TXNDC11 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TXNDC11
    GenScript Custom Superior Antibodies Services for TXNDC11
    Novus Biologicals TXNDC11 Antibodies
    Abcam antibodies for TXNDC11
    Cloud-Clone Corp. Antibodies for TXNDC11 
    Search ThermoFisher Antibodies for TXNDC11
    LSBio Antibodies in human, mouse, rat for TXNDC11 

    Assay Products for TXNDC11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TXNDC11
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TXNDC11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TXNDC11 
    Cloud-Clone Corp. CLIAs for TXNDC11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR013766 Thioredoxin_domain
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6PKC3

    ProtoNet protein and cluster: Q6PKC3

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TXD11_HUMAN, Q6PKC3
    Similarity: Belongs to the protein disulfide isomerase family
    Similarity: Contains 2 thioredoxin domains


    TXNDC11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXD11_HUMAN, Q6PKC3
    Function: May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2
    suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is
    however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation

    Phenotypes:
         1 MGI phenotypic allele for Txndc11 (no phenotypes)


    TXNDC11 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TXNDC11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TXNDC11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TXNDC11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TXNDC11 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNDC11
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNDC11:
    hsa-miR-3163 hsa-miR-29a* hsa-miR-4282
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TXNDC11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNDC11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TXNDC11
    Sirion Biotech Customized adenovirus for overexpression of TXNDC11

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TXNDC11 (see all 7)
    OriGene ORF clones in mouse, rat for TXNDC11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TXNDC11 (NM_015914)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNDC11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC11
    Sirion Biotech Customized lentivirus for stable overexpression of TXNDC11 
                         Customized lentivirus expression plasmids for stable overexpression of TXNDC11 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TXNDC11
    Search LifeMap BioReagents cell lines for TXNDC11
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TXNDC11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/22 Interacting proteins for TXNDC11 (Q6PKC32, 3 ENSP000002830334) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2872920 I2D: score=3 STRING: ENSP00000344782
    KRT15P190123, ENSP000002540434I2D: score=4 STRING: ENSP00000254043
    DUOX1Q9NRD93, ENSP000003179974I2D: score=1 STRING: ENSP00000317997
    TPOP072023, ENSP000003298694I2D: score=1 STRING: ENSP00000329869
    APCP250543I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045454cell redox homeostasis IEA--

    TXNDC11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TXNDC11 (TXD11)

    Search CenterWatch for drugs/clinical trials and news about TXNDC11 / TXD11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TXNDC11 gene: 
    NM_015914.5  

    Unigene Cluster for TXNDC11:

    Thioredoxin domain containing 11
    Hs.313847  [show with all ESTs]
    Unigene Representative Sequence: BC002856
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283033(uc002dbg.1) ENST00000570917 ENST00000356957(uc010buu.1)
    ENST00000575349 ENST00000572732 ENST00000575591 ENST00000576969 ENST00000571882
    ENST00000573174
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXNDC11
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TXNDC11:
    hsa-miR-3163 hsa-miR-29a* hsa-miR-4282
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TXNDC11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNDC11
    Clone
    Products:
         
    OriGene clones in human, mouse for TXNDC11 (see all 7)
    OriGene ORF clones in mouse, rat for TXNDC11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TXNDC11 (NM_015914)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXNDC11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC11
    Sirion Biotech Customized lentivirus for stable overexpression of TXNDC11 
                         Customized lentivirus expression plasmids for stable overexpression of TXNDC11 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TXNDC11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXNDC11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC11

    Additional mRNA sequence: 

    AF131780.1 AK027464.1 AK027646.1 AK074534.1 AK297094.1 BC002856.1 BC013727.1 BC018635.2 
    BX648407.1 CR457152.1 

    16 DOTS entries:

    DT.40126694  DT.447430  DT.101980962  DT.92440994  DT.101980963  DT.120656182  DT.100776378  DT.120656177 
    DT.97846332  DT.40191440  DT.91906292  DT.95374641  DT.97771102  DT.120656220  DT.40246110  DT.91675198 

    24/178 AceView cDNA sequences (see all 178):

    BM989770 BM998116 AI025142 BC013727 AI033959 AI124893 M79219 BX427040 
    BM682482 BQ227252 CA488394 BM713021 BM743119 BM668927 AI813964 AW589294 
    BM706005 BM684401 AW206511 BQ014077 AA359283 AI290828 BE396943 BM546108 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC11 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                -           -                                                                           
    SP2:                                            -                                                                           
    SP3:                                                                                                                        
    SP4:                                            -                                                                           
    SP5:                                -           -     -     -                                                               


    ECgene alternative splicing isoforms for TXNDC11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TXNDC11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGGAAAC
    TXNDC11 Expression
    About this image


    See TXNDC11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TXNDC11

    SOURCE GeneReport for Unigene cluster: Hs.313847

    UniProtKB/Swiss-Prot: TXD11_HUMAN, Q6PKC3
    Tissue specificity: Widely expressed at low level. Expressed at higher level in thyroid and prostate

        SABiosciences Custom PCR Arrays for TXNDC11
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TXNDC11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXNDC11
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC11
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TXNDC11 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txndc111 , 5 thioredoxin domain containing 111, 5 83.65(n)1
    83.19(a)1
      16 (6.33 cM)5
    1062001  NM_029582.21  NP_083858.11 
     110749115 
    chicken
    (Gallus gallus)
    Aves TXNDC111 thioredoxin domain containing 11 69.19(n)
    67.21(a)
      416428  XM_414741.3  XP_414741.3 
    lizard
    (Anolis carolinensis)
    Reptilia TXNDC116
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343691.1(250369-282257)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003304331 thioredoxin domain-containing protein 11-like 56.06(n)
    49.45(a)
      100330433  XM_002660673.1  XP_002660719.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG136716
    --
    20(a)
    1 ↔ 1
    3L(8293164-8295441)


    ENSEMBL Gene Tree for TXNDC11 (if available)
    TreeFam Gene Tree for TXNDC11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TXNDC11 gene

    TXNDC11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TXNDC11
    PGOHUM00000243958


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1452 SNPs in TXNDC11 are shown (see all 1452)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1415917471,2
    C,F--11773535(+) TGTGCC/GCCCGC 2 A G mis11Minor allele frequency- G:0.00NA 4552
    rs2007310091,2
    C--11773538(+) GCCCCC/TGCTGT 2 Q R mis10--------
    rs1463654811,2
    C--11773598(+) TCTGGG/AGGCTG 2 /P /L mis11Minor allele frequency- A:0.00NA 4552
    rs2012316901,2
    C--11773609(+) GAAGCA/CGGGTC 2 P syn11Minor allele frequency- C:0.00EU 1323
    rs31903211,2,4
    C,F,A,H--11773662(-) AAGACG/CTCCCC 2 /L /V mis1 ese326Minor allele frequency- C:0.49NS MN EA NA WA CSA EU 7688
    rs81913521,2
    C,F,H--11773733(+) TCACAC/GCAACA 1 -- int17Minor allele frequency- G:0.09NS EA NA 776
    rs71885111,2
    C,F,A,H--11773743(+) ACAATG/TAGTCC 1 -- int132Minor allele frequency- T:0.46NS NA EA WA CSA 3093
    rs771316201,2
    --11773800(+) AAAGAC/TGTTCC 1 -- int10--------
    rs794902301,2
    C,F--11773801(+) AAGACG/ATTCCG 1 -- int11Minor allele frequency- A:0.03EA 120
    rs81913531,2
    C,F,H--11773806(+) GTTCCG/ATGGAT 1 -- int18Minor allele frequency- A:0.10NS EA WA CSA 712

    HapMap Linkage Disequilibrium report for TXNDC11 (11772936 - 11836734 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TXNDC11:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662947CNV Deletion23128226
    nsv1734CNV Insertion18451855
    nsv524676CNV Loss19592680
    nsv525726CNV Gain19592680
    nsv457409CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TXNDC11
    DNA2.0 Custom Variant and Variant Library Synthesis for TXNDC11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for TXNDC11:    About MalaCards
    macular degeneration    ataxia    thyroiditis    alzheimer's disease
    prostatitis


    TXNDC11 for disorders           About GeneDecksing


    Export disorders for TXNDC11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TXNDC11 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with TXNDC11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel partner of duox: EFP1, a thioredoxin- related protein. (PubMed id 15561711)1, 2, 9 Wang D....Miot F. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
    5. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)
    9. Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
    10. Hepatitis C virus infection protein network. (PubMed id 18985028)1 de Chassey B....Lotteau V. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51061 HGNC: 28030 AceView: LOC51061 Ensembl:ENSG00000153066 euGenes: HUgn51061
    ECgene: TXNDC11 H-InvDB: TXNDC11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TXNDC11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TXNDC11 gene:
    Search GeneIP for patents involving TXNDC11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TXNDC11  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for TXNDC11   OriGene clones in human, mouse for TXNDC11  
     OriGene qSTAR qPCR primer pairs in human, mouse for TXNDC11   OriGene Purified Protein for TXNDC11  
     OriGene ORF clones in mouse, rat for TXNDC11   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TXNDC11   OriGene Custom Protein Services for TXNDC11  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TXNDC11
     QIAGEN SeqTarget long-range PCR primers for resequencing TXNDC11
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC11
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXNDC11
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXNDC11
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXNDC11
     GenScript Custom Purified and Recombinant Proteins Services for TXNDC11 GenScript cDNA clones with any tag delivered in your preferred vector for TXNDC11
     GenScript Custom Assay Services for TXNDC11 GenScript Custom Superior Antibodies Services for TXNDC11
     GenScript Custom overexpressing Cell Line Services for TXNDC11 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TXNDC11 promoter
     Search Chromatin IP Primers for TXNDC11
     RT2 qPCR Primer Assay in human, mouse, rat TXNDC11
     Search GNC Networks for TXNDC11
     SABiosciences Custom PCR Arrays for TXNDC11
     Search Tocris compounds for TXNDC11 (TXD11)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TXNDC11 antibodies
     Antibodies for TXNDC11
     See all of Abcam's Antibodies, Kits and Proteins for TXNDC11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TXNDC11
     Antibodies for TXNDC11
     ELISAs for TXNDC11
     CLIAs for TXNDC11
     Search LifeMap BioReagents cell lines for TXNDC11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXNDC11
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TXNDC11
     SwitchGear Promoter luciferase reporter plasmids for TXNDC11
     Search ThermoFisher Antibodies for TXNDC11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXNDC11
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TXNDC11
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TXNDC11
    Customized:
     lentivirus for stable overexpression of TXNDC11
     lentivirus expression plasmids for stable overexpression of TXNDC11
     adenovirus for overexpression of TXNDC11
     LSBio Antibodies in human, mouse, rat for TXNDC11
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TXNDC11 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4