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Aliases for TXNDC11 Gene

Aliases for TXNDC11 Gene

  • Thioredoxin Domain Containing 11 2 3
  • EF-Hand Binding Protein 1 2 3
  • EF-Hand-Binding Protein 1 3 4
  • EFP1 3 4
  • Thioredoxin Domain-Containing Protein 11 3

External Ids for TXNDC11 Gene

Summaries for TXNDC11 Gene

GeneCards Summary for TXNDC11 Gene

TXNDC11 (Thioredoxin Domain Containing 11) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TXNDC11 Gene

  • May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC11 Gene

Genomics for TXNDC11 Gene

Genomic Location for TXNDC11 Gene

11,679,080 bp from pter
11,742,878 bp from pter
63,799 bases
Minus strand

Genomic View for TXNDC11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXNDC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC11 Gene

Regulatory Elements for TXNDC11 Gene

Proteins for TXNDC11 Gene

  • Protein details for TXNDC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 11
    Protein Accession:
    Secondary Accessions:
    • O95887
    • Q6PJA6
    • Q8N2Q4
    • Q96K45
    • Q96K53

    Protein attributes for TXNDC11 Gene

    985 amino acids
    Molecular mass:
    110529 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA.
    • Sequence=AAD20043.1; Type=Frameshift; Positions=618; Evidence={ECO:0000305}; Sequence=AAH13727.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55129.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11044.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for TXNDC11 Gene


neXtProt entry for TXNDC11 Gene

Proteomics data for TXNDC11 Gene at MOPED

Post-translational modifications for TXNDC11 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn326 and Asn337

Other Protein References for TXNDC11 Gene

No data available for DME Specific Peptides for TXNDC11 Gene

Domains for TXNDC11 Gene

Protein Domains for TXNDC11 Gene


  • Contains 2 thioredoxin domains.:
    • Q6PKC3
  • Belongs to the protein disulfide isomerase family.:
    • Q6PKC3
genes like me logo Genes that share domains with TXNDC11: view

No data available for Gene Families for TXNDC11 Gene

Function for TXNDC11 Gene

Molecular function for TXNDC11 Gene

UniProtKB/Swiss-Prot Function: May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation

Gene Ontology (GO) - Molecular Function for TXNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IBA --
GO:0005515 protein binding IPI 18985028
genes like me logo Genes that share ontologies with TXNDC11: view

miRNA for TXNDC11 Gene

miRTarBase miRNAs that target TXNDC11

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TXNDC11 Gene

Localization for TXNDC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC11 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TXNDC11 Gene COMPARTMENTS Subcellular localization image for TXNDC11 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
plasma membrane 3
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TXNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TXNDC11: view

Pathways for TXNDC11 Gene

SuperPathways for TXNDC11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0034976 response to endoplasmic reticulum stress IBA --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TXNDC11: view

No data available for Pathways by source for TXNDC11 Gene

Transcripts for TXNDC11 Gene

Unigene Clusters for TXNDC11 Gene

Thioredoxin domain containing 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: -
SP4: -
SP5: - - - -
SP6: - - -
SP9: - - - -

Relevant External Links for TXNDC11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC11 Gene

mRNA expression in normal human tissues for TXNDC11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXNDC11 Gene

SOURCE GeneReport for Unigene cluster for TXNDC11 Gene Hs.313847

mRNA Expression by UniProt/SwissProt for TXNDC11 Gene

Tissue specificity: Widely expressed at low level. Expressed at higher level in thyroid and prostate.
genes like me logo Genes that share expressions with TXNDC11: view

Orthologs for TXNDC11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TXNDC11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TXNDC11 37
  • 96 (a)
(Bos Taurus)
Mammalia TXNDC11 36
  • 87.5 (n)
  • 87.9 (a)
TXNDC11 37
  • 87 (a)
(Canis familiaris)
Mammalia TXNDC11 36
  • 88.61 (n)
  • 89.01 (a)
TXNDC11 37
  • 86 (a)
(Mus musculus)
Mammalia Txndc11 36
  • 83.3 (n)
  • 83.22 (a)
Txndc11 16
Txndc11 37
  • 81 (a)
(Monodelphis domestica)
Mammalia TXNDC11 37
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 73 (a)
-- 37
  • 58 (a)
(Rattus norvegicus)
Mammalia Txndc11 36
  • 82.99 (n)
  • 82.77 (a)
(Gallus gallus)
Aves TXNDC11 36
  • 68.88 (n)
  • 66.74 (a)
TXNDC11 37
  • 66 (a)
(Anolis carolinensis)
Reptilia TXNDC11 37
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc11 36
  • 62.31 (n)
  • 59.04 (a)
(Danio rerio)
Actinopterygii LOC100330433 36
  • 56.28 (n)
  • 49.32 (a)
txndc11 37
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13671 37
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
CSA.8061 37
  • 22 (a)
Species with no ortholog for TXNDC11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TXNDC11 Gene

Gene Tree for TXNDC11 (if available)
Gene Tree for TXNDC11 (if available)

Paralogs for TXNDC11 Gene Pseudogenes for TXNDC11 Gene

genes like me logo Genes that share paralogs with TXNDC11: view

No data available for Paralogs for TXNDC11 Gene

Variants for TXNDC11 Gene

Sequence variations from dbSNP and Humsavar for TXNDC11 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs732799 -- 11,691,024(+) AAATC(A/G)CCAAT intron-variant
rs933573 -- 11,699,539(-) TTTCC(A/G)AATGG intron-variant
rs933574 -- 11,698,844(-) CTGTG(G/T)GCCTG intron-variant
rs1138233 -- 11,689,240(-) gcaat(A/G)gtgga intron-variant
rs1344532 -- 11,695,056(-) TGTTT(C/T)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC11 Gene

Variant ID Type Subtype PubMed ID
nsv457409 CNV Gain 19166990
nsv524676 CNV Loss 19592680
nsv1734 CNV Insertion 18451855
nsv525726 CNV Gain 19592680
esv2662947 CNV Deletion 23128226

Relevant External Links for TXNDC11 Gene

HapMap Linkage Disequilibrium report

Disorders for TXNDC11 Gene

No disorders were found for TXNDC11 Gene.

No data available for UniProtKB/Swiss-Prot for TXNDC11 Gene

Publications for TXNDC11 Gene

  1. Identification of a novel partner of duox: EFP1, a thioredoxin- related protein. (PMID: 15561711) Wang D. … Miot F. (J. Biol. Chem. 2005) 3 4 23
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TXNDC11 Gene

Sources for TXNDC11 Gene

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