Aliases for TXN2 Gene
External Ids for TXN2 Gene
Previous GeneCards Identifiers for TXN2 Gene
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for TXN2 Gene
TXN2 (Thioredoxin 2) is a Protein Coding gene. Diseases associated with TXN2 include penile cancer and ocular hypertension. Among its related pathways are Cellular Senescence and Detoxification of Reactive Oxygen Species. GO annotations related to this gene include protein complex binding and oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor.
UniProtKB/Swiss-Prot for TXN2 Gene
Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity.