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Aliases for TXN2 Gene

Aliases for TXN2 Gene

  • Thioredoxin 2 2 3
  • Thioredoxin-2 3 4
  • MT-TRX 3 4
  • TRX2 3 4
  • MTRX 3 4
  • Mitochondrial Thioredoxin 3

External Ids for TXN2 Gene

Previous GeneCards Identifiers for TXN2 Gene

  • GC22M033477
  • GC22M035105
  • GC22M035106
  • GC22M035187
  • GC22M036863
  • GC22M019831

Summaries for TXN2 Gene

Entrez Gene Summary for TXN2 Gene

  • This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TXN2 Gene

TXN2 (Thioredoxin 2) is a Protein Coding gene. Diseases associated with TXN2 include penile neoplasm and ocular hypertension. Among its related pathways are Glucose / Energy Metabolism and Cellular Senescence. GO annotations related to this gene include protein complex binding and oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor.

UniProtKB/Swiss-Prot for TXN2 Gene

  • Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity.

Gene Wiki entry for TXN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXN2 Gene

Genomics for TXN2 Gene

Regulatory Elements for TXN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TXN2 Gene

Chromosome:
22
Start:
36,467,036 bp from pter
End:
36,482,030 bp from pter
Size:
14,995 bases
Orientation:
Minus strand

Genomic View for TXN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXN2 Gene

Proteins for TXN2 Gene

  • Protein details for TXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99757-THIOM_HUMAN
    Recommended name:
    Thioredoxin, mitochondrial
    Protein Accession:
    Q99757
    Secondary Accessions:
    • Q5JZA0
    • Q6FH60
    • Q9UH29

    Protein attributes for TXN2 Gene

    Size:
    166 amino acids
    Molecular mass:
    18383 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for TXN2 Gene

neXtProt entry for TXN2 Gene

Proteomics data for TXN2 Gene at MOPED

Post-translational modifications for TXN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TXN2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TXN2 (TXN2)

No data available for DME Specific Peptides for TXN2 Gene

Domains & Families for TXN2 Gene

Protein Domains for TXN2 Gene

Suggested Antigen Peptide Sequences for TXN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99757

UniProtKB/Swiss-Prot:

THIOM_HUMAN :
  • Contains 1 thioredoxin domain.
  • Belongs to the thioredoxin family.
Domain:
  • Contains 1 thioredoxin domain.
Family:
  • Belongs to the thioredoxin family.
genes like me logo Genes that share domains with TXN2: view

No data available for Gene Families for TXN2 Gene

Function for TXN2 Gene

Molecular function for TXN2 Gene

UniProtKB/Swiss-Prot Function:
Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity.

Gene Ontology (GO) - Molecular Function for TXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008113 peptide-methionine (S)-S-oxide reductase activity IEA --
GO:0015035 protein disulfide oxidoreductase activity IBA --
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA --
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with TXN2: view
genes like me logo Genes that share phenotypes with TXN2: view

Animal Models for TXN2 Gene

MGI Knock Outs for TXN2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TXN2 Gene

Localization for TXN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXN2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXN2 Gene COMPARTMENTS Subcellular localization image for TXN2 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IDA 12032145
GO:0005759 mitochondrial matrix TAS --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with TXN2: view

Pathways & Interactions for TXN2 Gene

genes like me logo Genes that share pathways with TXN2: view

Pathways by source for TXN2 Gene

1 Cell Signaling Technology pathway for TXN2 Gene
1 BioSystems pathway for TXN2 Gene

Gene Ontology (GO) - Biological Process for TXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000103 sulfate assimilation IBA --
GO:0000302 response to reactive oxygen species TAS --
GO:0001666 response to hypoxia IEA --
GO:0006457 protein folding IBA --
GO:0006662 glycerol ether metabolic process IEA --
genes like me logo Genes that share ontologies with TXN2: view

No data available for SIGNOR curated interactions for TXN2 Gene

Drugs & Compounds for TXN2 Gene

(10) Drugs for TXN2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Nitric Oxide Approved Pharma 540
Dihydrolipoate Experimental Pharma 0
Selenocysteine Experimental Pharma 0
Imexon Investigational Pharma 0

(12) Additional Compounds for TXN2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Oxo acid
diamide
glucose
gssg
H2O2
genes like me logo Genes that share compounds with TXN2: view

Transcripts for TXN2 Gene

Unigene Clusters for TXN2 Gene

Thioredoxin 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:
SP6: - - -
SP7: - -

Relevant External Links for TXN2 Gene

GeneLoc Exon Structure for
TXN2
ECgene alternative splicing isoforms for
TXN2

Expression for TXN2 Gene

mRNA expression in normal human tissues for TXN2 Gene

Protein differential expression in normal tissues from HIPED for TXN2 Gene

This gene is overexpressed in Testis (11.4) and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TXN2 Gene



SOURCE GeneReport for Unigene cluster for TXN2 Gene Hs.211929

mRNA Expression by UniProt/SwissProt for TXN2 Gene

Q99757-THIOM_HUMAN
Tissue specificity: Widely expressed in adult (at protein level) and fetal tissues.
genes like me logo Genes that share expression patterns with TXN2: view

Protein tissue co-expression partners for TXN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TXN2 Gene

Orthologs for TXN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TXN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TXN2 35
  • 88.55 (n)
  • 88.55 (a)
TXN2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TXN2 35
  • 89.37 (n)
  • 90.18 (a)
TXN2 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Txn2 35
  • 85.94 (n)
  • 88.55 (a)
Txn2 16
Txn2 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Txn2 35
  • 85.14 (n)
  • 87.95 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TXN2 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves TXN2 35
  • 71.89 (n)
  • 76.12 (a)
TXN2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TXN2 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6528 35
txn2 35
  • 67.96 (n)
  • 72.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia txn2-prov 35
zebrafish
(Danio rerio)
Actinopterygii txn2 35
  • 63.98 (n)
  • 62.11 (a)
txn2 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta TRX2 35
  • 54.99 (n)
  • 43.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8993 35
  • 60.67 (n)
  • 48 (a)
CG3719 36
  • 34 (a)
OneToMany
CG8517 36
  • 38 (a)
OneToMany
CG8993 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trx-2 35
  • 52.11 (n)
  • 45.07 (a)
trx-2 36
  • 42 (a)
OneToOne
Species with no ortholog for TXN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXN2 Gene

ENSEMBL:
Gene Tree for TXN2 (if available)
TreeFam:
Gene Tree for TXN2 (if available)

Paralogs for TXN2 Gene

(1) SIMAP similar genes for TXN2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TXN2 Gene

genes like me logo Genes that share paralogs with TXN2: view

No data available for Paralogs for TXN2 Gene

Variants for TXN2 Gene

Sequence variations from dbSNP and Humsavar for TXN2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs8487 -- 36,467,218(+) GAGGC(A/C)GCTCC utr-variant-3-prime
rs139999 -- 36,467,328(+) CAGAC(A/C)TACAA utr-variant-3-prime
rs1062055 -- 36,467,388(-) AAAAA(A/G)AAAAA utr-variant-3-prime, downstream-variant-500B
rs2267337 -- 36,474,424(+) CTTGC(C/T)GCAGG intron-variant
rs2281082 -- 36,476,703(+) TGGCT(G/T)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXN2 Gene

Variant ID Type Subtype PubMed ID
nsv520497 CNV Gain 19592680
nsv834186 CNV Loss 17160897
esv2663104 CNV Deletion 23128226

Variation tolerance for TXN2 Gene

Residual Variation Intolerance Score: 41.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXN2 Gene

HapMap Linkage Disequilibrium report
TXN2
Human Gene Mutation Database (HGMD)
TXN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXN2 Gene

Disorders for TXN2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TXN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
penile neoplasm
  • penile tumor
ocular hypertension
- elite association
Search TXN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TXN2

Genetic Association Database (GAD)
TXN2
Human Genome Epidemiology (HuGE) Navigator
TXN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXN2
genes like me logo Genes that share disorders with TXN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXN2 Gene

Publications for TXN2 Gene

  1. Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha. (PMID: 17220299) Zhou J. … BrA1ne B. (J. Biol. Chem. 2007) 2 23 67
  2. Pulmonary injury and antioxidant response in mice exposed to arsenate and hexavalent chromium and their combination. (PMID: 19895865) Tajima H. … Harada T. (Toxicology 2010) 23 67
  3. Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors. (PMID: 19931534) Gurusamy N. … Das D.K. (FEBS Lett. 2010) 23 67
  4. Thioredoxins 1 and 2 protect retinal ganglion cells from pharmacologically induced oxidative stress, optic nerve transection and ocular hypertension. (PMID: 20238036) Munemasa Y. … Piri N. (Adv. Exp. Med. Biol. 2010) 23 67
  5. Changes in the expression of mitochondrial peroxiredoxin and thioredoxin in neurons and glia and their protective effects in experimental cerebral ischemic damage. (PMID: 20156553) Hwang I.K. … Won M.H. (Free Radic. Biol. Med. 2010) 23 67

Products for TXN2 Gene

Sources for TXN2 Gene

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