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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TXN2 Gene

protein-coding   GIFtS: 61
GCID: GC22M036863

Thioredoxin 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thioredoxin 21 2     Thioredoxin, Mitochondrial2
MTRX2 3     thioredoxin-22
TRX22 3     Mt-Trx3
MT-TRX2     Thioredoxin-23
Mitochondrial Thioredoxin2     

External Ids:    HGNC: 177721   Entrez Gene: 258282   Ensembl: ENSG000001003487   OMIM: 6090635   UniProtKB: Q997573   

Export aliases for TXN2 gene to outside databases

Previous GC identifers: GC22M033477 GC22M035105 GC22M035106 GC22M035187 GC22M019831


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TXN2 Gene:
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional
redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial
membrane potential and in protection against oxidant-induced apoptosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for TXN2 Gene: 
TXN2 (thioredoxin 2) is a protein-coding gene. Diseases associated with TXN2 include urethra cancer, and spina bifida. GO annotations related to this gene include electron carrier activity and protein disulfide oxidoreductase activity.

UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757
Function: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane
potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity

Gene Wiki entry for TXN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TXN2 gene promoter:
         NF-YA   CBF-C   MZF-1   NF-YB   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TXN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

TXN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXN2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M036863:  view genomic region     (about GC identifiers)

Start:
36,863,083 bp from pter      End:
36,878,077 bp from pter
Size:
14,995 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757 (See protein sequence)
Recommended Name: Thioredoxin, mitochondrial precursor  
Size: 166 amino acids; 18383 Da
Subunit: Monomer
Subcellular location: Mitochondrion
3 PDB 3D structures from and Proteopedia for TXN2:
1UVZ (3D)        1W4V (3D)        1W89 (3D)    
Secondary accessions: Q5JZA0 Q6FH60 Q9UH29

Explore the universe of human proteins at neXtProt for TXN2: NX_Q99757

Explore proteomics data for TXN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99757

  • TXN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TXN2 Protein Expression
    REFSEQ proteins: NP_036605.2  
    ENSEMBL proteins: 
     ENSP00000216185   ENSP00000469160   ENSP00000385393   ENSP00000409407  

    Human Recombinant Protein Products for TXN2: 
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    Novus Biologicals TXN2 Proteins
    Novus Biologicals TXN2 Lysate
    Sino Biological Recombinant Protein for TXN2
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TXN2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body IEA--

    TXN2 for ontologies           About GeneDecksing



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    Assay Products for TXN2: 
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    Cloud-Clone Corp. ELISAs for TXN2 
    Cloud-Clone Corp. CLIAs for TXN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS
     IPR005746 Thioredoxin
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q99757

    ProtoNet protein and cluster: Q99757

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757
    Similarity: Belongs to the thioredoxin family
    Similarity: Contains 1 thioredoxin domain


    TXN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THIOM_HUMAN, Q99757
    Function: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane
    potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0032403protein complex binding IEA--
         
    TXN2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TXN2:
     Decreased Salmonella enterica   Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Txn2):
     cellular  embryogenesis  growth/size  mortality/aging  nervous system 
     no phenotypic analysis 

    TXN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Txn2tm1Afst for TXN2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TXN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TXN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TXN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TXN2 

    miRNA
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    miRTarBase miRNAs that target TXN2:
    hsa-mir-16 (MIRT001402)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXN2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TXN2 (see all 18):
    hsa-miR-520d-5p hsa-miR-15a hsa-miR-424 hsa-miR-3613-3p hsa-miR-2116 hsa-miR-3662 hsa-miR-195 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidTXN2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Sirion Biotech Customized lentivirus for stable overexpression of TXN2 
                         Customized lentivirus expression plasmids for stable overexpression of TXN2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TXN2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Oxidative Stress
    Oxidative Stress


    1 BioSystems Pathway for TXN2
        Oxidative Stress



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TXN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for TXN2 (Q997573 ENSP000002161854) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    MLH1P406923I2D: score=1 
    POLD2P490053I2D: score=1 
    UBR5ENSP000002209594STRING: ENSP00000220959
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006662glycerol ether metabolic process IEA--
    GO:0006979response to oxidative stress IEA--
    GO:0007584response to nutrient IEA--
    GO:0009725response to hormone stimulus IEA--

    TXN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TXN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TXN2 (THIOM)

    10/22 Novoseek inferred chemical compound relationships for TXN2 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    imexon 86.5 1 16321833 (1)
    dihydrolipoic acid 63 1 12631263 (1)
    2-oxo acid 62.2 1 12631263 (1)
    tert-butylhydroperoxide 55.1 4 16797630 (3)
    gssg 49.9 1 16337887 (1)
    diamide 48.3 2 17113580 (2)
    selenocysteine 46 1 15901730 (1)
    cysteine 42.1 1 18267127 (1)
    oxygen 38.5 3 15082714 (1), 19506101 (1), 16407224 (1)
    manganese superoxide 35.8 1 11990504 (1)

    Search CenterWatch for drugs/clinical trials and news about TXN2 / THIOM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TXN2 gene: 
    NM_012473.3  

    Unigene Cluster for TXN2:

    Thioredoxin 2
    Hs.211929  [show with all ESTs]
    Unigene Representative Sequence: AK123361
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216185(uc003apk.1 uc003apl.1) ENST00000416967 ENST00000487725
    ENST00000403313 ENST00000411915
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TXN2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TXN2 (see all 18):
    hsa-miR-520d-5p hsa-miR-15a hsa-miR-424 hsa-miR-3613-3p hsa-miR-2116 hsa-miR-3662 hsa-miR-195 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidTXN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TXN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXN2
    Clone
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    OriGene ORF clones in mouse, rat for TXN2
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    GenScript: all cDNA clones in your preferred vector: TXN2 (NM_002973)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXN2
    Sirion Biotech Customized lentivirus for stable overexpression of TXN2 
                         Customized lentivirus expression plasmids for stable overexpression of TXN2 
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    OriGene qPCR primer pairs and template standards for TXN2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXN2

    Additional mRNA sequence: 

    AF276920.1 AF480262.1 AK123361.1 AK130187.1 AK301837.1 BC013726.1 BC050610.1 CR456601.2 
    CR541896.1 CR541917.1 U78678.1 

    17 DOTS entries:

    DT.102840739  DT.447659  DT.97816348  DT.120643634  DT.100817631  DT.318223  DT.120643560  DT.120643611 
    DT.97795103  DT.100817625  DT.100029033  DT.100817626  DT.100817633  DT.120643636  DT.120643662  DT.97844963 
    DT.92435426 

    24/536 AceView cDNA sequences (see all 536):

    BU615316 AI346017 CA442740 BQ880539 BQ691701 BQ690115 F10516 CN481396 
    NM_012473 AA363694 BU197096 AI129013 CN484300 BQ892409 BU196797 CB156467 
    BE673443 BQ001010 AW044436 AA331147 BM746653 BQ688174 BQ687570 BQ685876 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TXN2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
    SP1:                    -                             -                                       
    SP2:                    -     -                       -                                       
    SP3:                    -     -     -                 -                                       
    SP4:                                                  -                                       
    SP5:                                                                                          


    ECgene alternative splicing isoforms for TXN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TXN2 expression in normal human tissues (normalized intensities)      TXN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTAGAGCCC
    TXN2 Expression
    About this image


    TXN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See TXN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TXN2

    SOURCE GeneReport for Unigene cluster: Hs.211929

    UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757
    Tissue specificity: Widely expressed in adult (at protein level) and fetal tissues

        SABiosciences Custom PCR Arrays for TXN2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TXN2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txn21 , 5 thioredoxin 21, 5 85.94(n)1
    88.55(a)1
      15 (36.92 cM)5
    565511  NM_019913.51  NP_064297.11 
     779150475 
    chicken
    (Gallus gallus)
    Aves TXN21 thioredoxin 2 72.18(n)
    76.69(a)
      426978  NM_001031410.1  NP_001026581.1 
    lizard
    (Anolis carolinensis)
    Reptilia TXN26
    Uncharacterized protein
    65(a)
    1 ↔ 1
    5(22176239-22196962)
    African clawed frog
    (Xenopus laevis)
    Amphibia txn2-prov2 thioredoxin 2 79.44(n)    BC043794.1 
    zebrafish
    (Danio rerio)
    Actinopterygii txn21 thioredoxin 2 69.6(n)
    71.2(a)
      402938  NM_205641.1  NP_991204.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG89931 CG8993 60.67(n)
    48(a)
      38301  NM_139459.3  NP_647716.1 
    worm
    (Caenorhabditis elegans)
    Secernentea trx-21 Protein TRX-2 52.83(n)
    46.23(a)
      179434  NM_073250.6  NP_505651.2 


    ENSEMBL Gene Tree for TXN2 (if available)
    TreeFam Gene Tree for TXN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TXN2 gene
    1 SIMAP similar gene for TXN2 using alignment to 3 protein entries:     THIOM_HUMAN (see all proteins):
    TXN

    TXN2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TXN2
    PGOHUM00000244777


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/453 SNPs in TXN2 are shown (see all 453)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
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    ----------
    rs105346621,2
    C--19833685(+) GAAAC-/TCAGGGA 1 -- int11Minor allele frequency- TC:0.00NA 2
    rs1831390161,2
    --36862616(+) CCTTGC/GCACAC 1 -- ds50010--------
    rs1891613491,2
    --36862682(+) CAGAAA/GTTCCT 1 -- ds50010--------
    rs1922542121,2
    --36862696(+) GGCACC/TCATGG 1 -- ds50010--------
    rs1113174851,2
    F--36862826(+) AACCAC/TGTCTG 1 -- ds50012Minor allele frequency- T:0.03CSA WA 120
    rs1394961441,2
    C--36862868(+) CACAGC/TGTCTA 1 -- ds50010--------
    rs734076951,2
    C,F--36862910(+) CTTAGG/CAGGGC 1 -- ds50013Minor allele frequency- C:0.15WA CSA 122
    rs1846414611,2
    --36862918(+) GGCACA/GAGGAC 1 -- ds50010--------
    rs1879568481,2
    --36862967(+) AAGCAC/TGTTAG 1 -- ds50010--------
    rs1916151551,2
    --36862990(+) GCTGGC/TTGGAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TXN2 (36863083 - 36878077 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TXN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663104CNV Deletion23128226
    nsv834186CNV Loss17160897
    nsv520497CNV Gain19592680


    Human Gene Mutation Database (HGMD): TXN2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TXN2
    DNA2.0 Custom Variant and Variant Library Synthesis for TXN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609063    OMIM disorders: --

    19 diseases for TXN2:    About MalaCards
    urethra cancer    spina bifida    hyperhomocysteinemia    multiple myeloma
    hypoxia    myeloma    pneumonia    osteosarcoma
    neuroblastoma    tuberculosis    asthma    hypertension
    colon cancer    cerebritis    retinitis    hepatocellular carcinoma
    breast cancer    endotheliitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for TXN2:
    Urethra cancer

    TXN2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TXN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 4.6 1 12215208 (1)

    Genetic Association Database (GAD): TXN2
    Human Genome Epidemiology (HuGE) Navigator: TXN2 (9 documents)

    Export disorders for TXN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TXN2 gene, integrated from 9 sources (see all 99):
    (articles sorted by number of sources associating them with TXN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells. (PubMed id 12032145)1, 2, 9 Chen Y.... Jones D.P. (2002)
    2. Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. (PubMed id 12080052)1, 2, 9 Damdimopoulos A.E.... Spyrou G. (2002)
    3. Genetic polymorphisms in the thioredoxin 2 (TXN2) gene and risk for spina bifida. (PubMed id 19165900)1, 4, 9 Wen S....Finnell R.H. (2009)
    4. Thioredoxin 1 and thioredoxin 2 have opposed regulato ry functions on hypoxia-inducible factor-1alpha. (PubMed id 17220299)1, 3, 9 Zhou J....BrA1ne B. (2007)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    7. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (2009)
    8. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    9. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    10. Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer. (PubMed id 17634480)1, 4 Udler M....Pharoah P. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25828 HGNC: 17772 AceView: TXN2andFLJ23322 Ensembl:ENSG00000100348 euGenes: HUgn25828
    ECgene: TXN2 H-InvDB: TXN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TXN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TXN2 gene:
    Search GeneIP for patents involving TXN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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