Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TXLNG Gene

Aliases for TXLNG Gene

  • Taxilin Gamma 2 3 5
  • Factor Inhibiting Activating Transcription Factor 4 (ATF4)-Mediated Transcription 2 3
  • Environmental Lipopolysaccharide-Responding Gene Protein 3 4
  • Lipopolysaccharide Specific Response-5 Protein 2 3
  • Lipopolysaccharide-Specific Response Protein 5 3 4
  • Factor Inhibiting ATF4-Mediated Transcription 3 4
  • CXorf15 3 4
  • ELRG 3 4
  • FIAT 3 4
  • LSR5 3 4
  • Chromosome X Open Reading Frame 15 2
  • Environmental LPS-Responding 3
  • TXLNGX 3

External Ids for TXLNG Gene

Previous HGNC Symbols for TXLNG Gene

  • CXorf15

Previous GeneCards Identifiers for TXLNG Gene

  • GC0XP016804
  • GC0XP014564

Summaries for TXLNG Gene

Entrez Gene Summary for TXLNG Gene

  • This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for TXLNG Gene

TXLNG (Taxilin Gamma) is a Protein Coding gene. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2. GO annotations related to this gene include protein heterodimerization activity and syntaxin binding. An important paralog of this gene is TXLNB.

UniProtKB/Swiss-Prot for TXLNG Gene

  • May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXLNG Gene

Genomics for TXLNG Gene

Regulatory Elements for TXLNG Gene

Enhancers for TXLNG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TXLNG on UCSC Golden Path with GeneCards custom track

Promoters for TXLNG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TXLNG on UCSC Golden Path with GeneCards custom track

Genomic Location for TXLNG Gene

16,786,427 bp from pter
16,844,519 bp from pter
58,093 bases
Plus strand

Genomic View for TXLNG Gene

Genes around TXLNG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXLNG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXLNG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXLNG Gene

Proteins for TXLNG Gene

  • Protein details for TXLNG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q2KQ75
    • Q5JNZ7
    • Q9P0X1

    Protein attributes for TXLNG Gene

    528 amino acids
    Molecular mass:
    60586 Da
    Quaternary structure:
    • Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Forms a heterodimer with ATF4 in osteoblasts.
    • Depletion of TXLNG by siRNA decreases the percentage of Hep-G2 cells arrested in G1 phase.

    Alternative splice isoforms for TXLNG Gene


neXtProt entry for TXLNG Gene

Proteomics data for TXLNG Gene at MOPED

Post-translational modifications for TXLNG Gene

  • Ubiquitination at Lys 275
  • Modification sites at PhosphoSitePlus

Other Protein References for TXLNG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TXLNG Gene

Domains & Families for TXLNG Gene

Protein Domains for TXLNG Gene


Suggested Antigen Peptide Sequences for TXLNG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the taxilin family.
  • Belongs to the taxilin family.
genes like me logo Genes that share domains with TXLNG: view

No data available for Gene Families for TXLNG Gene

Function for TXLNG Gene

Molecular function for TXLNG Gene

UniProtKB/Swiss-Prot Function:
May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.
UniProtKB/Swiss-Prot Induction:
By bacterial lipopolysaccharides (LPS) in Hep-G2 cells.
genes like me logo Genes that share phenotypes with TXLNG: view

Animal Models for TXLNG Gene

MGI Knock Outs for TXLNG:

Animal Model Products

miRNA for TXLNG Gene

miRTarBase miRNAs that target TXLNG

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TXLNG Gene

Localization for TXLNG Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXLNG Gene

Nucleus membrane. Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for TXLNG Gene COMPARTMENTS Subcellular localization image for TXLNG gene
Compartment Confidence
cytosol 5
nucleus 5
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TXLNG Gene

Pathways & Interactions for TXLNG Gene

genes like me logo Genes that share pathways with TXLNG: view

Pathways by source for TXLNG Gene

Gene Ontology (GO) - Biological Process for TXLNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030500 regulation of bone mineralization ISS --
GO:0051726 regulation of cell cycle ISS --
genes like me logo Genes that share ontologies with TXLNG: view

No data available for SIGNOR curated interactions for TXLNG Gene

Drugs & Compounds for TXLNG Gene

No Compound Related Data Available

Transcripts for TXLNG Gene

Unigene Clusters for TXLNG Gene

Taxilin gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXLNG Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b
SP2: -
SP4: -

Relevant External Links for TXLNG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXLNG Gene

mRNA expression in normal human tissues for TXLNG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TXLNG Gene

This gene is overexpressed in Fetal ovary (14.8), Adrenal (13.8), Breast (10.7), and Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXLNG Gene

SOURCE GeneReport for Unigene cluster for TXLNG Gene Hs.555961

mRNA Expression by UniProt/SwissProt for TXLNG Gene

Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas.
genes like me logo Genes that share expression patterns with TXLNG: view

Protein tissue co-expression partners for TXLNG Gene

Primer Products

No data available for mRNA differential expression in normal tissues for TXLNG Gene

Orthologs for TXLNG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXLNG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TXLNG 35
  • 86.51 (n)
  • 89.78 (a)
  • 88 (a)
(Canis familiaris)
Mammalia TXLNG 35
  • 89.4 (n)
  • 90.8 (a)
  • 90 (a)
(Mus musculus)
Mammalia Txlng 35
  • 88.93 (n)
  • 90.79 (a)
Txlng 16
Gm8258 36
  • 94 (a)
Txlng 36
  • 87 (a)
(Pan troglodytes)
Mammalia TXLNG 35
  • 98.74 (n)
  • 97.99 (a)
-- 36
  • 70 (a)
CYHYorf15A 36
  • 71 (a)
  • 92 (a)
(Rattus norvegicus)
Mammalia Txlng 35
  • 86.78 (n)
  • 90 (a)
(Monodelphis domestica)
Mammalia TXLNG 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
-- 36
  • 87 (a)
(Gallus gallus)
Aves TXLNG 35
  • 76.18 (n)
  • 81.67 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia TXLNG 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1600 35
txlng 35
  • 67.85 (n)
  • 71.91 (a)
(Danio rerio)
Actinopterygii txlng 35
  • 65.07 (n)
  • 66.88 (a)
txlng 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5886 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea T22C1.6 36
  • 26 (a)
(Zea mays)
Liliopsida Zm.12913 35
Species with no ortholog for TXLNG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXLNG Gene

Gene Tree for TXLNG (if available)
Gene Tree for TXLNG (if available)

Paralogs for TXLNG Gene

Paralogs for TXLNG Gene

(5) SIMAP similar genes for TXLNG Gene using alignment to 1 proteins: Pseudogenes for TXLNG Gene

genes like me logo Genes that share paralogs with TXLNG: view

Variants for TXLNG Gene

Sequence variations from dbSNP and Humsavar for TXLNG Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5969783 - 16,829,642(+) TCCAG(A/G)TTACC reference, missense
rs747685376 -- 16,808,542(+) ACTCA(-/C)CCAGT intron-variant
rs747710060 -- 16,815,225(+) GGCTG(G/T)AGTGC intron-variant
rs747742991 -- 16,794,633(+) TCAGA(A/G)GTGTA intron-variant
rs747752103 -- 16,843,189(+) TTGCT(G/T)ACTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TXLNG Gene

Variant ID Type Subtype PubMed ID
esv2668322 CNV Deletion 23128226

Variation tolerance for TXLNG Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TXLNG Gene

Disorders for TXLNG Gene

Relevant External Links for TXLNG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TXLNG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXLNG Gene

Publications for TXLNG Gene

  1. Identification and characterization of taxilin isoforms. (PMID: 15184072) Nogami S. … Shirataki H. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 23 67
  2. Inhibition of ATF4 transcriptional activity by FIAT/gamma-taxilin modulates bone mass accrual. (PMID: 16831913) Yu V.W. … St-Arnaud R. (Ann. N. Y. Acad. Sci. 2006) 2 3
  3. FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. (PMID: 15911876) Yu V.W. … St-Arnaud R. (J. Cell Biol. 2005) 2 3
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3

Products for TXLNG Gene

Sources for TXLNG Gene