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Aliases for TXLNG Gene

Aliases for TXLNG Gene

  • Taxilin Gamma 2 3
  • CXorf15 3 4 6
  • FIAT 3 4 6
  • Factor Inhibiting Activating Transcription Factor 4 (ATF4)-Mediated Transcription 2 3
  • Environmental Lipopolysaccharide-Responding Gene Protein 3 4
  • Lipopolysaccharide Specific Response-5 Protein 2 3
  • Lipopolysaccharide-Specific Response Protein 5 3 4
  • Factor Inhibiting ATF4-Mediated Transcription 3 4
  • ELRG 3 4
  • LSR5 3 4
  • Chromosome X Open Reading Frame 15 2
  • Environmental LPS-Responding 3
  • Gamma-Taxilin 3
  • TXLNGX 3

External Ids for TXLNG Gene

Previous Symbols for TXLNG Gene

  • CXorf15

Summaries for TXLNG Gene

Entrez Gene Summary for TXLNG Gene

  • This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for TXLNG Gene

TXLNG (Taxilin Gamma) is a Protein Coding gene. Diseases associated with TXLNG include scarlet fever and antisocial personality disorder. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2. GO annotations related to this gene include protein heterodimerization activity and syntaxin binding. An important paralog of this gene is TXLNB.

UniProtKB/Swiss-Prot for TXLNG Gene

  • May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXLNG Gene

Genomics for TXLNG Gene

Genomic Location for TXLNG Gene

Start:
16,786,427 bp from pter
End:
16,844,519 bp from pter
Size:
58,093 bases
Orientation:
Plus strand

Genomic View for TXLNG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXLNG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXLNG Gene

No data available for Regulatory Elements for TXLNG Gene

Proteins for TXLNG Gene

  • Protein details for TXLNG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUQ3-TXLNG_HUMAN
    Recommended name:
    Gamma-taxilin
    Protein Accession:
    Q9NUQ3
    Secondary Accessions:
    • Q2KQ75
    • Q5JNZ7
    • Q9P0X1

    Protein attributes for TXLNG Gene

    Size:
    528 amino acids
    Molecular mass:
    60586 Da
    Quaternary structure:
    • Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Forms a heterodimer with ATF4 in osteoblasts.
    Miscellaneous:
    • Depletion of TXLNG by siRNA decreases the percentage of Hep-G2 cells arrested in G1 phase

    Alternative splice isoforms for TXLNG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TXLNG Gene

Proteomics data for TXLNG Gene at MOPED

Post-translational modifications for TXLNG Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys275

Other Protein References for TXLNG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TXLNG Gene

Domains for TXLNG Gene

Protein Domains for TXLNG Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TXLNG_HUMAN
Family:
  • Belongs to the taxilin family.:
    • Q9NUQ3
genes like me logo Genes that share domains with TXLNG: view

No data available for Gene Families for TXLNG Gene

Function for TXLNG Gene

Molecular function for TXLNG Gene

UniProtKB/Swiss-Prot Function: May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.
UniProtKB/Swiss-Prot Induction: By bacterial lipopolysaccharides (LPS) in Hep-G2 cells.

Gene Ontology (GO) - Molecular Function for TXLNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019905 syntaxin binding IEA --
GO:0046982 protein heterodimerization activity IDA 15911876
genes like me logo Genes that share ontologies with TXLNG: view

Phenotypes for TXLNG Gene

MGI mutant phenotypes for TXLNG:
inferred from 1 alleles
GenomeRNAi human phenotypes for TXLNG:
genes like me logo Genes that share phenotypes with TXLNG: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TXLNG Gene

Localization for TXLNG Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXLNG Gene

Nucleus membrane. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXLNG Gene COMPARTMENTS Subcellular localization image for TXLNG gene
Compartment Confidence
nucleus 5
cytosol 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for TXLNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol ISS --
GO:0031965 nuclear membrane IDA 15911876
genes like me logo Genes that share ontologies with TXLNG: view

Pathways for TXLNG Gene

genes like me logo Genes that share pathways with TXLNG: view

Pathways by source for TXLNG Gene

Gene Ontology (GO) - Biological Process for TXLNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0010564 regulation of cell cycle process IMP 18068885
GO:0030500 regulation of bone mineralization ISS --
genes like me logo Genes that share ontologies with TXLNG: view

Transcripts for TXLNG Gene

Unigene Clusters for TXLNG Gene

Taxilin gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXLNG Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b
SP1:
SP2: -
SP3:
SP4: -
SP5:

Relevant External Links for TXLNG Gene

GeneLoc Exon Structure for
TXLNG
ECgene alternative splicing isoforms for
TXLNG

Expression for TXLNG Gene

mRNA expression in normal human tissues for TXLNG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXLNG Gene

SOURCE GeneReport for Unigene cluster for TXLNG Gene Hs.555961

mRNA Expression by UniProt/SwissProt for TXLNG Gene

Q9NUQ3-TXLNG_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas.
genes like me logo Genes that share expressions with TXLNG: view

Orthologs for TXLNG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXLNG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 70 (a)
OneToMany
CYHYorf15A 37
  • 71 (a)
OneToMany
TXLNG 36
  • 98.74 (n)
  • 97.99 (a)
TXLNG 37
  • 92 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TXLNG 36
  • 86.51 (n)
  • 89.78 (a)
TXLNG 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TXLNG 36
  • 89.4 (n)
  • 90.8 (a)
TXLNG 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm8258 37
  • 94 (a)
OneToMany
Txlng 36
  • 88.93 (n)
  • 90.79 (a)
Txlng 16
Txlng 37
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TXLNG 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 71 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Txlng 36
  • 86.78 (n)
  • 90 (a)
chicken
(Gallus gallus)
Aves TXLNG 36
  • 76.18 (n)
  • 81.67 (a)
TXLNG 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TXLNG 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1600 36
txlng 36
  • 67.85 (n)
  • 71.91 (a)
zebrafish
(Danio rerio)
Actinopterygii txlng 36
  • 65.07 (n)
  • 66.88 (a)
txlng 37
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5886 37
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T22C1.6 37
  • 26 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.12913 36
Species with no ortholog for TXLNG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXLNG Gene

ENSEMBL:
Gene Tree for TXLNG (if available)
TreeFam:
Gene Tree for TXLNG (if available)

Paralogs for TXLNG Gene

Paralogs for TXLNG Gene

Selected SIMAP similar genes for TXLNG Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TXLNG Gene

genes like me logo Genes that share paralogs with TXLNG: view

Variants for TXLNG Gene

Sequence variations from dbSNP and Humsavar for TXLNG Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs648129 -- 16,801,225(-) ctggg(C/T)gacag intron-variant
rs2291126 -- 16,837,315(+) GCACT(C/T)CACAT intron-variant
rs3747366 -- 16,842,011(-) AGGCA(A/G)TGAAC utr-variant-3-prime
rs3747367 -- 16,834,204(-) TAGGC(G/T)TCATC intron-variant
rs3788872 -- 16,826,102(-) CCTTC(G/T)CTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXLNG Gene

Variant ID Type Subtype PubMed ID
esv2668322 CNV Deletion 23128226

Relevant External Links for TXLNG Gene

HapMap Linkage Disequilibrium report
TXLNG
Locus Specific Mutation Databases (LSDB)
TXLNG

Disorders for TXLNG Gene

(2) University of Copenhagen DISEASES for TXLNG Gene

genes like me logo Genes that share disorders with TXLNG: view

No data available for UniProtKB/Swiss-Prot for TXLNG Gene

Publications for TXLNG Gene

  1. Identification and characterization of taxilin isoforms. (PMID: 15184072) Nogami S. … Shirataki H. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 23
  2. FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. (PMID: 15911876) Yu V.W. … St-Arnaud R. (J. Cell Biol. 2005) 2 3 4
  3. Inhibition of ATF4 transcriptional activity by FIAT/gamma-taxilin modulates bone mass accrual. (PMID: 16831913) Yu V.W. … St-Arnaud R. (Ann. N. Y. Acad. Sci. 2006) 2 3
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TXLNG Gene

Sources for TXLNG Gene

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