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TXLNG Gene

protein-coding   GIFtS: 52
GCID: GC0XP016804

Taxilin Gamma

(Previous name: chromosome X open reading frame 15)
(Previous symbol: CXorf15)
  See TXLNG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Taxilin Gamma1 2     Lipopolysaccharide-Specific Response Protein 52 3
CXorf151 2 3 5     ELRG2 3
FIAT2 3 5     LSR52 3
Factor Inhibiting Activating Transcription Factor 4 (ATF4)-Mediated
Transcription1 2
     Chromosome X Open Reading Frame 151
Lipopolysaccharide Specific Response-5 Protein1 2     Environmental LPS-Responding2
Environmental Lipopolysaccharide-Responding Gene Protein2 3     gamma-taxilin2
Factor Inhibiting ATF4-Mediated Transcription2 3     

External Ids:    HGNC: 185781   Entrez Gene: 557872   Ensembl: ENSG000000867127   OMIM: 3006775   UniProtKB: Q9NUQ33   

Export aliases for TXLNG gene to outside databases

Previous GC identifer: GC0XP014564


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TXLNG Gene:
This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region
of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is
up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related
mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus
regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Dec 2009)

GeneCards Summary for TXLNG Gene:
TXLNG (taxilin gamma) is a protein-coding gene. Diseases associated with TXLNG include scarlet fever, and antisocial personality disorder. GO annotations related to this gene include protein heterodimerization activity and syntaxin binding. An important paralog of this gene is TXLNA.

UniProtKB/Swiss-Prot: TXLNG_HUMAN, Q9NUQ3
Function: May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by
dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass
density through an ATF4-dependent pathway. May be involved in cell cycle progression




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TXLNG
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXLNG promoter sequence
   Search Chromatin IP Primers for TXLNG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXLNG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.2

TXLNG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXLNG gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP016804:  view genomic region     (about GC identifiers)

Start:
16,804,550 bp from pter      End:
16,862,642 bp from pter
Size:
58,093 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TXLNG_HUMAN, Q9NUQ3 (See protein sequence)
Recommended Name: Gamma-taxilin  
Size: 528 amino acids; 60586 Da
Subunit: Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Forms a
heterodimer with ATF4 in osteoblasts
Miscellaneous: Depletion of TXLNG by siRNA decreases the percentage of Hep-G2 cells arrested in G1 phase
Secondary accessions: Q2KQ75 Q5JNZ7 Q9P0X1
Alternative splicing: 2 isoforms:  Q9NUQ3-1   Q9NUQ3-2   

Explore the universe of human proteins at neXtProt for TXLNG: NX_Q9NUQ3

Explore proteomics data for TXLNG at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys275
  • Modification sites at PhosphoSitePlus

  • See TXLNG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001162154.1  NP_060830.2  

    ENSEMBL proteins: 
     ENSP00000369465   ENSP00000381222  

    TXLNG Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026183 Taxilin_fam

    Graphical View of Domain Structure for InterPro Entry Q9NUQ3

    ProtoNet protein and cluster: Q9NUQ3

    UniProtKB/Swiss-Prot: TXLNG_HUMAN, Q9NUQ3
    Similarity: Belongs to the taxilin family


    Find genes that share domains with TXLNG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXLNG_HUMAN, Q9NUQ3
    Function: May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by
    dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass
    density through an ATF4-dependent pathway. May be involved in cell cycle progression
    Induction: By bacterial lipopolysaccharides (LPS) in Hep-G2 cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019905syntaxin binding IEA--
    GO:0046982protein heterodimerization activity IDA15911876
         
    Find genes that share ontologies with TXLNG           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TXLNG:
     Increased circadian period len 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Txlng):
     normal 

    Find genes that share phenotypes with TXLNG           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TXLNG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TXLNG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TXLNG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TXLNG

    miRNA
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    miRTarBase miRNAs that target TXLNG:
    hsa-mir-340-5p (MIRT019585), hsa-mir-16-5p (MIRT051225), hsa-mir-26a-5p (MIRT050092), hsa-mir-550a-3p (MIRT040501), hsa-mir-98-5p (MIRT027599)

    Block miRNA regulation of human, mouse, rat TXLNG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TXLNG (see all 146):
    hsa-miR-199a-3p hsa-miR-128 hsa-miR-1245 hsa-miR-3622b-3p hsa-miR-200b hsa-miR-761 hsa-miR-374b* hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidTXLNG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TXLNG

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): TXLNG (NM_018360)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXLNG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXLNG

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXLNG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TXLNG_HUMAN, Q9NUQ3: Nucleus membrane. Cytoplasm, cytosol (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ISS--
    GO:0031965nuclear membrane IDA15911876

    Find genes that share ontologies with TXLNG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TXLNG About    
    See pathways by source

    SuperPathContained pathways About
    1Validated transcriptional targets of AP1 family members Fra1 and Fra2
    Validated transcriptional targets of AP1 family members Fra1 and Fra2


    1 BioSystems Pathway for TXLNG
        Validated transcriptional targets of AP1 family members Fra1 and Fra2


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TXLNG
    Interactions:

        Search GeneGlobe Interaction Network for TXLNG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for TXLNG (Q9NUQ33 ENSP000003694654) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAXP612443, ENSP000003514904I2D: score=3 STRING: ENSP00000351490
    TBK1Q9UHD23, ENSP000003299674I2D: score=1 STRING: ENSP00000329967
    TXLNAP402223, ENSP000003627114I2D: score=1 STRING: ENSP00000362711
    TXLNBQ8N3L33, ENSP000003512064I2D: score=1 STRING: ENSP00000351206
    AZI2Q9H6S13, ENSP000004193714I2D: score=1 STRING: ENSP00000419371
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007049cell cycle IEA--
    GO:0010564regulation of cell cycle process IMP18068885
    GO:0030500regulation of bone mineralization ISS--

    Find genes that share ontologies with TXLNG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TXLNG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TXLNG gene (2 alternative transcripts): 
    NM_001168683.1  NM_018360.2  

    Unigene Cluster for TXLNG:

    Taxilin gamma
    Hs.555961  [show with all ESTs]
    Unigene Representative Sequence: NM_018360
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380122(uc004cxq.2 uc010ney.2) ENST00000485153 ENST00000398155

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TXLNG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TXLNG (see all 146):
    hsa-miR-199a-3p hsa-miR-128 hsa-miR-1245 hsa-miR-3622b-3p hsa-miR-200b hsa-miR-761 hsa-miR-374b* hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidTXLNG 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TXLNG
    Predesigned siRNA for gene silencing in human, mouse, rat TXLNG
    Clone
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    OriGene ORF clones in mouse, rat for TXLNG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TXLNG (NM_018360)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXLNG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXLNG
    Primer
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    OriGene qPCR primer pairs and template standards for TXLNG
    OriGene qSTAR qPCR primer pairs in human, mouse for TXLNG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TXLNG
      QuantiTect SYBR Green Assays in human, mouse, rat TXLNG
      QuantiFast Probe-based Assays in human, mouse, rat TXLNG

    Additional mRNA sequence: 

    AF143740.2 AK002071.1 AK123142.1 AY739713.1 BC101572.1 BC101576.1 

    9 DOTS entries:

    DT.75161272  DT.95326291  DT.121292389  DT.121292414  DT.100880557  DT.91853219  DT.100746943  DT.91858758 
    DT.95117139 

    Selected AceView cDNA sequences (see all 114):

    W67375 BQ003917 AA927432 W73779 AW468783 BM983557 AA496347 CA413773 
    AA371431 AA812199 AA319266 BU624992 AA731379 AA730235 AA761272 BX092695 
    W73769 BM876618 AI367369 AW243533 AW197225 BU509308 AW118048 BX954775 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TXLNG    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b
    SP1:                                                                                                      
    SP2:        -                                                                                             
    SP3:                                                                                                      
    SP4:                                                                                      -               
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for TXLNG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TXLNG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TXLNG Expression
    About this image


    TXLNG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TXLNG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TXLNG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.555961

    UniProtKB/Swiss-Prot: TXLNG_HUMAN, Q9NUQ3
    Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in
    brain, placenta, lung, liver, kidney and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXLNG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TXLNG gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txlng1 , 5 taxilin gamma1, 5 88.93(n)1
    90.79(a)1
      X (74.99 cM)5
    3531701  NM_178935.41  NP_849266.11 
     1627789195 
    chicken
    (Gallus gallus)
    Aves TXLNG1 taxilin gamma 76.18(n)
    81.67(a)
      418618  XM_416817.4  XP_416817.2 
    lizard
    (Anolis carolinensis)
    Reptilia TXLNG6
    taxilin gamma
    73(a)
    1 ↔ 1
    3(122124590-122138732)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.16002 Transcribed sequence with moderate similarity to protein more 79.82(n)    142033817 
    zebrafish
    (Danio rerio)
    Actinopterygii txlng1 taxilin gamma 65.07(n)
    66.88(a)
      324984  NM_001044311.1  NP_001037776.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58866
    --
    23(a)
    1 → many
    3R(21677376-21679727)
    worm
    (Caenorhabditis elegans)
    Secernentea T22C1.66
    Protein T22C1.6 (T22C1.6) mRNA, complete cds
    26(a)
    1 → many
    I(7942719-7945588) WBGene00011917
    corn
    (Zea mays)
    Liliopsida Zm.129132 Zea mays transcribed sequence with weak similarity more 77.05(n)    CK371630.1 


    ENSEMBL Gene Tree for TXLNG (if available)
    TreeFam Gene Tree for TXLNG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TXLNG gene
    TXLNA2  TXLNB2  
    5 SIMAP similar genes for TXLNG using alignment to 1 protein entry:     TXLNG_HUMAN:
    CYorf15B    TXLNB    TXLNA    DKFZp451B226    DKFZp451H216

    Find genes that share paralogs with TXLNG           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TXLNG
    PGOHUM00000249983


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TXLNG (see all 852)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862923471,2
    --14563057(+) AAAAAA/CTAGAG 2 -- us2k10--------
    rs1910771121,2
    --14563164(+) TTGTTA/CAAAAT 2 -- us2k10--------
    rs59343281,2
    C,F,A,H--14563727(+) AGTTTC/TTCAAC 2 -- us2k14Minor allele frequency- T:0.43NA WA 7
    rs1885204941,2
    --16802690(+) AGGCAC/TGTGTC 2 -- us2k10--------
    rs1931685271,2
    --16802783(+) TGATCC/TGCCCG 2 -- us2k10--------
    rs1846285211,2
    --16802962(+) AAAAAA/TTTTTT 2 -- us2k10--------
    rs1898460551,2
    --16803177(+) CTTTGC/GGAGGC 2 -- us2k10--------
    rs1912525421,2
    --16803736(+) TCCCCC/TCCAAC 2 -- us2k10--------
    rs1839388601,2
    --16803924(+) TCCCGC/TGGGAG 2 -- us2k10--------
    rs732071311,2
    C,F--16804012(+) AATTCG/TAAGAG 2 -- us2k13Minor allele frequency- T:0.25WA NA CSA 4

    HapMap Linkage Disequilibrium report for TXLNG (16804550 - 16862642 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TXLNG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668322CNV Deletion23128226

    Locus Specific Mutation Databases (LSDB): TXLNG

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TXLNG
    DNA2.0 Custom Variant and Variant Library Synthesis for TXLNG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300677    OMIM disorders: --

    2 diseases for TXLNG:    
    About MalaCards
    scarlet fever    antisocial personality disorder

    2 diseases from the University of Copenhagen DISEASES database for TXLNG:
    Scarlet fever     Antisocial personality disorder

    Find genes that share disorders with TXLNG           About GenesLikeMe


    Export disorders for TXLNG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TXLNG gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with TXLNG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of taxilin isoforms. (PubMed id 15184072)1, 2, 3, 9 Nogami S.... Shirataki H. (Biochem. Biophys. Res. Commun. 2004)
    2. FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. (PubMed id 15911876)1, 2, 3 Yu V.W.... St-Arnaud R. (J. Cell Biol. 2005)
    3. Over-expression and siRNA of a novel environmental lipopolysaccharide-responding gene on the cell cycle of the human hepatoma-derived cell line HepG2. (PubMed id 18068885)1, 2 Du K.... Chen J. (Toxicology 2008)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. Inhibition of ATF4 transcriptional activity by FIAT/gamma-taxilin modulates bone mass accrual. (PubMed id 16831913)1, 3 Yu V.W....St-Arnaud R. (Ann. N. Y. Acad. Sci. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55787 HGNC: 18578 AceView: CXorf15 Ensembl:ENSG00000086712 euGenes: HUgn55787
    ECgene: TXLNG H-InvDB: TXLNG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TXLNG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TXLNG gene:
    Search GeneIP for patents involving TXLNG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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